SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSL_A_PZIA800_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdv CYTOCHROME C6

(Pyropia
yezoensis) 		PF13442
(Cytochrome_CBB3) 		4 ASN A  42
LEU A  36
LYS A  29
SER A  40
 None
None
HEM  A 101 (-3.3A)
None
 1.41A 3lslA-1gdvA:
undetectable
3lslD-1gdvA:
undetectable		 3lslA-1gdvA:
15.48
3lslD-1gdvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gux RETINOBLASTOMA
PROTEIN

(Homo sapiens) 		PF01858
(RB_A) 		4 LEU A 572
ASP A 571
LYS A 574
SER A 567
 None
 1.37A 3lslA-1guxA:
undetectable
3lslD-1guxA:
undetectable		 3lslA-1guxA:
22.61
3lslD-1guxA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TYR A  31
MET A  56
LEU A  65
ASP A  64
 GOL  A 303 (-4.3A)
None
None
None
 1.36A 3lslA-1kqjA:
undetectable
3lslD-1kqjA:
undetectable		 3lslA-1kqjA:
22.66
3lslD-1kqjA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		4 TYR A   7
ASN A  51
LEU A  55
ASP A  52
 None
 1.15A 3lslA-1ljyA:
undetectable
3lslD-1ljyA:
undetectable		 3lslA-1ljyA:
22.16
3lslD-1ljyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc)
PF14671
(DSPn) 		4 TYR A 248
ASN A 217
LEU A 216
ASP A 215
 None
 1.41A 3lslA-1oheA:
undetectable
3lslD-1oheA:
undetectable		 3lslA-1oheA:
22.19
3lslD-1oheA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 TYR B  26
ASN B  52
LEU B  51
ASP B  50
 None
 1.20A 3lslA-1qlbB:
undetectable
3lslD-1qlbB:
undetectable		 3lslA-1qlbB:
23.21
3lslD-1qlbB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szh HER-1 PROTEIN

(Caenorhabditis
elegans) 		PF09232
(Caenor_Her-1) 		4 TYR A 137
LEU A 123
ASP A 124
LYS A 127
 None
 0.92A 3lslA-1szhA:
undetectable
3lslD-1szhA:
undetectable		 3lslA-1szhA:
20.96
3lslD-1szhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzq EQUINATOXIN II

(Actinia equina) 		PF06369
(Anemone_cytotox) 		4 TYR A 122
ASN A 118
LEU A 136
SER A 141
 None
 1.39A 3lslA-1tzqA:
undetectable
3lslD-1tzqA:
undetectable		 3lslA-1tzqA:
20.16
3lslD-1tzqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 TYR A 111
ASN A 144
LEU A 274
LYS A 208
 None
 1.21A 3lslA-1um8A:
undetectable
3lslD-1um8A:
undetectable		 3lslA-1um8A:
20.20
3lslD-1um8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 TYR A 164
LEU A 136
ASP A 137
SER A 254
 None
None
GTP  A 700 (-2.8A)
GTP  A 700 (-2.5A)
 1.36A 3lslA-1wdtA:
undetectable
3lslD-1wdtA:
undetectable		 3lslA-1wdtA:
16.52
3lslD-1wdtA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5z HYPOTHETICAL PROTEIN
SO2946

(Shewanella
oneidensis) 		no annotation 4 TYR A  53
MET A  56
ASP A 247
SER A  83
 None
None
MG  A 701 (-3.2A)
None
 1.01A 3lslA-2a5zA:
undetectable
3lslD-2a5zA:
undetectable		 3lslA-2a5zA:
23.67
3lslD-2a5zA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 TYR A 191
ASN A 250
LEU A 247
LYS A 243
 None
 1.35A 3lslA-2azkA:
undetectable
3lslD-2azkA:
undetectable		 3lslA-2azkA:
23.45
3lslD-2azkA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw9 TRANSLOCASE OF INNER
MITOCHONDRIAL
MEMBRANE

(Homo sapiens) 		PF04280
(Tim44) 		4 TYR A 348
LEU A 336
ASP A 337
LYS A 340
 None
 0.90A 3lslA-2cw9A:
undetectable
3lslD-2cw9A:
undetectable		 3lslA-2cw9A:
21.83
3lslD-2cw9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		4 ASN A 249
LEU A 252
ASP A 253
LYS A 256
 None
 1.41A 3lslA-2cybA:
undetectable
3lslD-2cybA:
undetectable		 3lslA-2cybA:
23.78
3lslD-2cybA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 ASN A 422
ASP A 442
LYS A 444
SER A 426
 None
 1.38A 3lslA-2i0oA:
undetectable
3lslD-2i0oA:
undetectable		 3lslA-2i0oA:
22.07
3lslD-2i0oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijr HYPOTHETICAL PROTEIN
API92

(Yersinia
pseudotuberculosis) 		PF06924
(DUF1281) 		4 TYR A  60
ASN A 182
LEU A 188
SER A 192
 None
 1.23A 3lslA-2ijrA:
undetectable
3lslD-2ijrA:
undetectable		 3lslA-2ijrA:
22.12
3lslD-2ijrA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q86 VALPHA14 TCR

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 TYR A  24
LEU A  65
ASP A  66
LYS A  70
 None
 1.26A 3lslA-2q86A:
undetectable
3lslD-2q86A:
undetectable		 3lslA-2q86A:
23.81
3lslD-2q86A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra1 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 TYR A 256
LEU A 220
ASP A 221
LYS A 224
 None
 0.96A 3lslA-2ra1A:
undetectable
3lslD-2ra1A:
undetectable		 3lslA-2ra1A:
21.14
3lslD-2ra1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Aquifex
aeolicus) 		PF00288
(GHMP_kinases_N) 		4 TYR A 175
ASN A 206
LEU A 208
SER A 236
 CDP  A1269 (-3.6A)
None
None
None
 1.35A 3lslA-2v8pA:
undetectable
3lslD-2v8pA:
undetectable		 3lslA-2v8pA:
22.62
3lslD-2v8pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 TYR A 281
ASN A 305
LEU A 308
ASP A 309
 None
 1.23A 3lslA-2yp1A:
undetectable
3lslD-2yp1A:
undetectable		 3lslA-2yp1A:
22.42
3lslD-2yp1A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2f LYSOZYME C-2

(Bos taurus) 		PF00062
(Lys) 		4 TYR A  38
LEU A  29
LYS A  33
SER A 122
 None
 1.03A 3lslA-2z2fA:
undetectable
3lslD-2z2fA:
undetectable		 3lslA-2z2fA:
18.78
3lslD-2z2fA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ASN A 110
LEU A  83
ASP A 106
SER A  85
 None
 1.39A 3lslA-2z7xA:
undetectable
3lslD-2z7xA:
undetectable		 3lslA-2z7xA:
19.20
3lslD-2z7xA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A 448
MET A 519
LEU A 776
LYS A 780
 None
 0.45A 3lslA-2znsA:
37.3
3lslD-2znsA:
36.9		 3lslA-2znsA:
51.92
3lslD-2znsA:
51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 TYR A 873
ASN A 886
LEU A 840
ASP A 839
 None
 1.19A 3lslA-2zxqA:
undetectable
3lslD-2zxqA:
undetectable		 3lslA-2zxqA:
12.39
3lslD-2zxqA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 TYR A 291
ASN A 285
ASP A 455
SER A 470
 None
 1.22A 3lslA-3ai7A:
undetectable
3lslD-3ai7A:
undetectable		 3lslA-3ai7A:
14.75
3lslD-3ai7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 ASN A 262
LEU A 259
ASP A 258
SER A 239
 None
 1.35A 3lslA-3bz5A:
undetectable
3lslD-3bz5A:
undetectable		 3lslA-3bz5A:
18.32
3lslD-3bz5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		4 TYR A 137
ASN A 102
ASP A  90
SER A  59
 None
 1.42A 3lslA-3e15A:
undetectable
3lslD-3e15A:
undetectable		 3lslA-3e15A:
23.81
3lslD-3e15A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 ASN A  70
LEU A 300
ASP A 301
LYS A 304
 None
 1.12A 3lslA-3ed4A:
undetectable
3lslD-3ed4A:
undetectable		 3lslA-3ed4A:
18.31
3lslD-3ed4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		4 TYR A  45
ASN A 245
LEU A 248
LYS A 252
 None
 1.10A 3lslA-3f0hA:
undetectable
3lslD-3f0hA:
undetectable		 3lslA-3f0hA:
22.28
3lslD-3f0hA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fav 6 KDA EARLY
SECRETORY ANTIGENIC
TARGET

(Mycobacterium
tuberculosis) 		PF06013
(WXG100) 		4 ASN B  66
LEU B  29
ASP B  30
LYS B  33
 None
None
ZN  B   1 (-2.4A)
None
 1.02A 3lslA-3favB:
undetectable
3lslD-3favB:
undetectable		 3lslA-3favB:
15.77
3lslD-3favB:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
filamentous
virus 1) 		no annotation 4 ASN A  58
LEU A  61
ASP A  62
LYS A  65
 None
 1.22A 3lslA-3fbzA:
undetectable
3lslD-3fbzA:
undetectable		 3lslA-3fbzA:
18.32
3lslD-3fbzA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 TYR A 194
ASN A 244
LEU A 241
ASP A 231
 None
 1.36A 3lslA-3girA:
undetectable
3lslD-3girA:
undetectable		 3lslA-3girA:
20.71
3lslD-3girA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 TYR A  35
MET A 107
LEU A 247
ASP A 248
LYS A 251
 None
None
CYZ  A 265 (-4.3A)
None
CYZ  A 265 ( 4.4A)
 0.96A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7		 3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 TYR A 317
ASN A 242
LEU A 273
ASP A 275
 None
 1.20A 3lslA-3hgqA:
undetectable
3lslD-3hgqA:
undetectable		 3lslA-3hgqA:
21.85
3lslD-3hgqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		4 TYR A 288
ASN A 122
LEU A 125
LYS A 129
 None
 1.35A 3lslA-3hjbA:
undetectable
3lslD-3hjbA:
undetectable		 3lslA-3hjbA:
17.74
3lslD-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 TYR A 354
LEU A 266
LYS A 352
SER A 307
 None
 0.93A 3lslA-3kl9A:
undetectable
3lslD-3kl9A:
undetectable		 3lslA-3kl9A:
21.82
3lslD-3kl9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		4 TYR A 206
LEU A 165
ASP A 170
SER A 194
 None
 1.37A 3lslA-3lezA:
undetectable
3lslD-3lezA:
undetectable		 3lslA-3lezA:
22.18
3lslD-3lezA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 TYR A  15
LEU A   9
ASP A   8
SER A  41
 None
 1.30A 3lslA-3mgxA:
undetectable
3lslD-3mgxA:
undetectable		 3lslA-3mgxA:
20.67
3lslD-3mgxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxh TRANSCRIPTIONAL
REGULATOR YVHJ

(Bacillus
subtilis) 		PF03816
(LytR_cpsA_psr) 		4 TYR A 282
LEU A 104
ASP A 105
LYS A 109
 None
 1.42A 3lslA-3nxhA:
undetectable
3lslD-3nxhA:
undetectable		 3lslA-3nxhA:
24.58
3lslD-3nxhA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 TYR A 675
MET A 327
ASN A 325
LEU A 324
 None
 1.44A 3lslA-3qdeA:
undetectable
3lslD-3qdeA:
undetectable		 3lslA-3qdeA:
15.61
3lslD-3qdeA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A 431
MET A 503
LEU A 760
LYS A 764
 None
 0.48A 3lslA-3qxmA:
13.3
3lslD-3qxmA:
37.1		 3lslA-3qxmA:
51.92
3lslD-3qxmA:
51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ASN A 503
LEU A 482
ASP A 481
SER A 505
 None
 1.06A 3lslA-3szeA:
undetectable
3lslD-3szeA:
undetectable		 3lslA-3szeA:
16.07
3lslD-3szeA:
16.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  35
MET A 106
LEU A 242
LYS A 246
 None
None
None
ZN  A 259 (-3.5A)
 0.37A 3lslA-3u92A:
36.9
3lslD-3u92A:
36.8		 3lslA-3u92A:
51.34
3lslD-3u92A:
51.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.16A 3lslA-3w1gA:
undetectable
3lslD-3w1gA:
undetectable		 3lslA-3w1gA:
17.51
3lslD-3w1gA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo9 VARIABLE LYMPHOCYTE
RECEPTOR C

(Lethenteron
camtschaticum) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ASN A  76
LEU A  73
ASP A  74
SER A  54
 None
 1.37A 3lslA-3wo9A:
undetectable
3lslD-3wo9A:
undetectable		 3lslA-3wo9A:
19.93
3lslD-3wo9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn8 SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF02978
(SRP_SPB) 		4 TYR M 421
MET M 384
ASN M 382
LEU M 381
 None
None
A  G  42 ( 4.1A)
None
 1.44A 3lslA-3zn8M:
undetectable
3lslD-3zn8M:
undetectable		 3lslA-3zn8M:
22.83
3lslD-3zn8M:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn8 SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF02978
(SRP_SPB) 		4 TYR M 421
MET M 384
LEU M 381
SER M 407
 None
 1.38A 3lslA-3zn8M:
undetectable
3lslD-3zn8M:
undetectable		 3lslA-3zn8M:
22.83
3lslD-3zn8M:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi3 SSP1

(Serratia
marcescens) 		PF14113
(Tae4) 		4 TYR A   5
LEU A 136
ASP A 135
SER A  14
 None
 1.43A 3lslA-4bi3A:
undetectable
3lslD-4bi3A:
undetectable		 3lslA-4bi3A:
20.23
3lslD-4bi3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buo NEUROTENSIN RECEPTOR
TYPE 1

(Rattus
norvegicus) 		PF00001
(7tm_1) 		4 ASN A 365
LEU A 109
ASP A 113
SER A 361
 None
 1.12A 3lslA-4buoA:
undetectable
3lslD-4buoA:
undetectable		 3lslA-4buoA:
21.70
3lslD-4buoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 LEU A 245
ASP A 246
LYS A 249
SER A 240
 None
CA  A1577 (-3.0A)
None
None
 0.80A 3lslA-4cj0A:
undetectable
3lslD-4cj0A:
undetectable		 3lslA-4cj0A:
18.02
3lslD-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 TYR A 139
ASN A 484
LEU A 487
ASP A 488
 None
 1.33A 3lslA-4cj0A:
undetectable
3lslD-4cj0A:
undetectable		 3lslA-4cj0A:
18.02
3lslD-4cj0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erv RYANODINE RECEPTOR 3

(Homo sapiens) 		PF02026
(RyR) 		4 TYR A2743
LEU A2787
ASP A2786
SER A2625
 None
 1.36A 3lslA-4ervA:
undetectable
3lslD-4ervA:
undetectable		 3lslA-4ervA:
21.92
3lslD-4ervA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3m BH0337 PROTEIN

(Bacillus
halodurans) 		PF09704
(Cas_Cas5d) 		4 TYR A  46
ASN A 113
ASP A 111
LYS A  48
 None
 1.43A 3lslA-4f3mA:
undetectable
3lslD-4f3mA:
undetectable		 3lslA-4f3mA:
21.58
3lslD-4f3mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 TYR A 508
LEU A 524
ASP A 525
LYS A 528
 None
 0.99A 3lslA-4fyeA:
undetectable
3lslD-4fyeA:
undetectable		 3lslA-4fyeA:
16.16
3lslD-4fyeA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 ASN A 157
LEU A 154
ASP A  54
SER A 126
 None
 1.33A 3lslA-4ghkA:
undetectable
3lslD-4ghkA:
undetectable		 3lslA-4ghkA:
20.04
3lslD-4ghkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		4 ASN A 108
LEU A  83
ASP A  82
LYS A  32
 None
 1.43A 3lslA-4h0fA:
undetectable
3lslD-4h0fA:
undetectable		 3lslA-4h0fA:
24.11
3lslD-4h0fA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens) 		PF04675
(DNA_ligase_A_N) 		4 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.10A 3lslA-4htpA:
undetectable
3lslD-4htpA:
undetectable		 3lslA-4htpA:
20.38
3lslD-4htpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 TYR A 347
MET A 288
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.41A 3lslA-4im7A:
undetectable
3lslD-4im7A:
undetectable		 3lslA-4im7A:
19.01
3lslD-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmq BACTERIOPHAGE T5
DISTAL TAIL PROTEIN

(Escherichia
virus T5) 		no annotation 4 TYR A  54
ASN A   9
LEU A  15
ASP A   5
 None
 1.22A 3lslA-4jmqA:
undetectable
3lslD-4jmqA:
undetectable		 3lslA-4jmqA:
19.85
3lslD-4jmqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 TYR A 278
ASN A 397
ASP A 370
SER A 394
 None
 1.30A 3lslA-4k05A:
undetectable
3lslD-4k05A:
undetectable		 3lslA-4k05A:
21.38
3lslD-4k05A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		4 TYR C 322
ASN C 334
LEU C 326
ASP C 329
 None
 1.23A 3lslA-4oogC:
undetectable
3lslD-4oogC:
undetectable		 3lslA-4oogC:
21.05
3lslD-4oogC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgu GAMMA-INTERFERON-IND
UCIBLE PROTEIN 16

(Homo sapiens) 		PF02760
(HIN) 		4 TYR A 218
ASN A 274
LEU A 245
LYS A 226
 None
 1.22A 3lslA-4qguA:
undetectable
3lslD-4qguA:
undetectable		 3lslA-4qguA:
19.41
3lslD-4qguA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 ASN A 204
LEU A 168
ASP A 171
LYS A 170
 None
 0.92A 3lslA-4uxvA:
undetectable
3lslD-4uxvA:
undetectable		 3lslA-4uxvA:
18.85
3lslD-4uxvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		4 ASN A  31
LEU A  98
ASP A  99
SER A  25
 None
 1.02A 3lslA-4w79A:
undetectable
3lslD-4w79A:
undetectable		 3lslA-4w79A:
20.57
3lslD-4w79A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 MET A 843
ASN A 703
ASP A 850
LYS A 854
 None
 1.16A 3lslA-4xgtA:
undetectable
3lslD-4xgtA:
undetectable		 3lslA-4xgtA:
15.12
3lslD-4xgtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ASN A 157
LEU A 154
LYS A 178
SER A 133
 None
 1.30A 3lslA-4z64A:
undetectable
3lslD-4z64A:
undetectable		 3lslA-4z64A:
15.59
3lslD-4z64A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3o THYMINE DIOXYGENASE

(Neurospora
crassa) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 TYR A 291
ASN A 150
ASP A 154
LYS A 157
 None
 1.35A 3lslA-5c3oA:
undetectable
3lslD-5c3oA:
undetectable		 3lslA-5c3oA:
23.32
3lslD-5c3oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		4 TYR A 343
LEU A 345
ASP A 232
SER A 188
 None
 1.06A 3lslA-5d6nA:
undetectable
3lslD-5d6nA:
undetectable		 3lslA-5d6nA:
19.09
3lslD-5d6nA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 TYR A  83
ASP A  96
LYS A 100
SER A  54
 None
 1.30A 3lslA-5d9aA:
undetectable
3lslD-5d9aA:
undetectable		 3lslA-5d9aA:
17.23
3lslD-5d9aA:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  39
MET A 111
LEU A 250
LYS A 254
 None
 0.52A 3lslA-5dtbA:
37.9
3lslD-5dtbA:
37.7		 3lslA-5dtbA:
54.79
3lslD-5dtbA:
54.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		4 TYR A 210
ASN A 194
ASP A 251
SER A 247
 None
 1.30A 3lslA-5feiA:
undetectable
3lslD-5feiA:
undetectable		 3lslA-5feiA:
17.28
3lslD-5feiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1
DICKKOPF-RELATED
PROTEIN 1

(Homo sapiens;
Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC)
no annotation 		4 TYR B 165
LEU C 190
LYS C 208
SER C 193
 None
 1.39A 3lslA-5fwwB:
undetectable
3lslD-5fwwB:
undetectable		 3lslA-5fwwB:
22.78
3lslD-5fwwB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5d CELLULOSOMAL-SCAFFOL
DING PROTEIN A

(Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1)
PF13620
(CarboxypepD_reg) 		4 TYR B 161
MET B  98
LEU B  74
ASP B  75
 None
 1.35A 3lslA-5g5dB:
undetectable
3lslD-5g5dB:
undetectable		 3lslA-5g5dB:
21.88
3lslD-5g5dB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 TYR A 101
ASN A 233
LEU A 212
ASP A 213
 None
None
None
TLA  A 403 (-3.2A)
 1.24A 3lslA-5hyhA:
undetectable
3lslD-5hyhA:
undetectable		 3lslA-5hyhA:
23.44
3lslD-5hyhA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il7 RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF12799
(LRR_4)
PF13516
(LRR_6) 		4 ASN A  95
LEU A  92
ASP A  93
SER A  72
 None
 1.31A 3lslA-5il7A:
undetectable
3lslD-5il7A:
undetectable		 3lslA-5il7A:
19.95
3lslD-5il7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm6 AMINOPEPTIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF02127
(Peptidase_M18) 		4 TYR A  58
LEU A 309
ASP A 307
SER A 390
 None
None
ZN  A 602 ( 4.3A)
None
 1.34A 3lslA-5jm6A:
undetectable
3lslD-5jm6A:
undetectable		 3lslA-5jm6A:
18.52
3lslD-5jm6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 431
MET A 503
LEU A 760
LYS A 764
 None
 0.87A 3lslA-5kufA:
34.4
3lslD-5kufA:
33.9		 3lslA-5kufA:
18.46
3lslD-5kufA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
MET A 496
LEU A 759
ASP A 760
LYS A 763
 None
 0.67A 3lslA-5l1bA:
22.2
3lslD-5l1bA:
22.4		 3lslA-5l1bA:
70.17
3lslD-5l1bA:
70.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 TYR A  62
ASN A 123
LEU A 141
ASP A 142
 None
 1.25A 3lslA-5l56A:
undetectable
3lslD-5l56A:
undetectable		 3lslA-5l56A:
12.11
3lslD-5l56A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5low RABPHILIN-3A

(Rattus
norvegicus) 		PF00168
(C2) 		4 TYR A 613
LEU A 625
ASP A 626
SER A 628
 None
 1.37A 3lslA-5lowA:
undetectable
3lslD-5lowA:
undetectable		 3lslA-5lowA:
20.85
3lslD-5lowA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 118
ASN A 216
LEU A 126
ASP A 123
 None
 1.06A 3lslA-5lt1A:
undetectable
3lslD-5lt1A:
undetectable		 3lslA-5lt1A:
22.26
3lslD-5lt1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 TYR A 185
LEU A 148
ASP A 149
LYS A 152
 None
 1.27A 3lslA-5m8tA:
undetectable
3lslD-5m8tA:
undetectable		 3lslA-5m8tA:
20.80
3lslD-5m8tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 RETICULOCYTE
BINDING-LIKE PROTEIN
5,RETICULOCYTE
BINDING PROTEIN 5

(Plasmodium
falciparum) 		no annotation 4 TYR A 184
LEU A 460
ASP A 461
LYS A 464
 None
 1.10A 3lslA-5mi0A:
undetectable
3lslD-5mi0A:
undetectable		 3lslA-5mi0A:
21.64
3lslD-5mi0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz PEROXIN 22

(Ogataea angusta) 		no annotation 4 ASN D 124
LEU D 143
ASP D 144
SER D 121
 None
 1.37A 3lslA-5nkzD:
2.7
3lslD-5nkzD:
2.8		 3lslA-5nkzD:
undetectable
3lslD-5nkzD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 MET A  31
ASN A  53
LEU A  43
SER A  41
 None
 1.42A 3lslA-5no8A:
undetectable
3lslD-5no8A:
undetectable		 3lslA-5no8A:
18.84
3lslD-5no8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 ASN A  60
LEU A  63
ASP A  64
LYS A  67
 None
 0.97A 3lslA-5ns8A:
undetectable
3lslD-5ns8A:
undetectable		 3lslA-5ns8A:
undetectable
3lslD-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 MET A 832
LEU A 811
ASP A 812
SER A 779
 None
 1.42A 3lslA-5u70A:
undetectable
3lslD-5u70A:
undetectable		 3lslA-5u70A:
13.21
3lslD-5u70A:
13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 424
MET A 496
LEU A 759
ASP A 760
 None
 0.53A 3lslA-5welA:
32.2
3lslD-5welA:
32.5		 3lslA-5welA:
66.67
3lslD-5welA:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 424
MET A 496
LEU A 759
LYS A 763
 None
 0.94A 3lslA-5welA:
32.2
3lslD-5welA:
32.5		 3lslA-5welA:
66.67
3lslD-5welA:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 424
MET A 496
LEU A 759
ASP A 760
 None
CYZ  A1302 (-4.3A)
None
CYZ  A1302 (-3.8A)
 0.56A 3lslA-5weoA:
25.4
3lslD-5weoA:
25.3		 3lslA-5weoA:
66.67
3lslD-5weoA:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 424
MET A 496
LEU A 759
LYS A 763
 None
CYZ  A1302 (-4.3A)
None
CYZ  A1302 (-2.9A)
 1.22A 3lslA-5weoA:
25.4
3lslD-5weoA:
25.3		 3lslA-5weoA:
66.67
3lslD-5weoA:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		4 TYR A 521
ASN A 668
LEU A 680
ASP A 681
 None
 1.33A 3lslA-5xblA:
undetectable
3lslD-5xblA:
undetectable		 3lslA-5xblA:
11.93
3lslD-5xblA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3AE, PUTATIVE

(Trichomonas
vaginalis) 		PF01015
(Ribosomal_S3Ae) 		4 ASN B 175
LEU B 180
ASP B 183
LYS B 182
 None
 1.34A 3lslA-5xyiB:
undetectable
3lslD-5xyiB:
undetectable		 3lslA-5xyiB:
25.00
3lslD-5xyiB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y33 ALGINATE LYASE

(Flavobacterium
sp. UMI-01) 		no annotation 4 TYR A 115
ASN A 193
LEU A 192
ASP A 106
 None
 1.37A 3lslA-5y33A:
undetectable
3lslD-5y33A:
undetectable		 3lslA-5y33A:
undetectable
3lslD-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-) 		no annotation 4 TYR A 252
ASN A 163
LEU A 166
ASP A 167
 None
 1.15A 3lslA-5yeuA:
undetectable
3lslD-5yeuA:
undetectable		 3lslA-5yeuA:
undetectable
3lslD-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9x SMALL RNA DEGRADING
NUCLEASE 1

(Arabidopsis
thaliana) 		no annotation 4 TYR A 109
ASN A  78
ASP A 235
SER A 125
 None
 1.27A 3lslA-5z9xA:
undetectable
3lslD-5z9xA:
undetectable		 3lslA-5z9xA:
undetectable
3lslD-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN

(Trypanosoma
brucei) 		no annotation 4 MET A  13
LEU A  10
ASP A   6
LYS A   5
 None
 1.28A 3lslA-6bm7A:
undetectable
3lslD-6bm7A:
undetectable		 3lslA-6bm7A:
undetectable
3lslD-6bm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS

(Homo sapiens) 		no annotation 4 TYR C  24
LEU C  66
ASP C  67
LYS C  71
 None
 1.40A 3lslA-6bnlC:
undetectable
3lslD-6bnlC:
undetectable		 3lslA-6bnlC:
undetectable
3lslD-6bnlC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2

(Saccharomyces
cerevisiae) 		no annotation 4 TYR B 637
LEU B 659
LYS B 663
SER B 544
 None
 1.20A 3lslA-6bzgB:
undetectable
3lslD-6bzgB:
undetectable		 3lslA-6bzgB:
undetectable
3lslD-6bzgB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d42 INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4

(Homo sapiens) 		no annotation 4 ASN A 384
LEU A 381
ASP A 380
LYS A 376
 None
 1.37A 3lslA-6d42A:
undetectable
3lslD-6d42A:
undetectable		 3lslA-6d42A:
undetectable
3lslD-6d42A:
undetectable