SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSK_B_ACTB901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 SER A  59
PHE A 205
PHE A 149
ASN A  89
 SAH  A 699 ( 3.9A)
None
None
SAH  A 699 (-4.9A)
 1.09A 3lskB-1dl5A:
2.0		 3lskB-1dl5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 GLN A 415
PHE A 321
HIS A 320
ASN A 409
 None
 1.09A 3lskB-1fbwA:
0.0		 3lskB-1fbwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7u 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		4 SER A  57
GLN A 113
PHE A 237
HIS A 202
 None
None
None
PEP  A 300 (-3.9A)
 1.46A 3lskB-1g7uA:
0.4		 3lskB-1g7uA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 SER A 283
PHE A 113
HIS A 112
ASN A 291
 None
 1.28A 3lskB-1mhsA:
0.0		 3lskB-1mhsA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		4 SER A  57
GLN A 113
PHE A 237
HIS A 202
 None
 1.34A 3lskB-1o60A:
0.1		 3lskB-1o60A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 SER A 350
PHE A 396
PHE A 407
ASN A 404
 None
 1.00A 3lskB-1rxtA:
0.6		 3lskB-1rxtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 SER A  62
GLN A 182
PHE A 186
HIS A 275
 None
 1.19A 3lskB-1tz7A:
undetectable		 3lskB-1tz7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 SER A 134
GLN A 166
PHE A 382
HIS A 353
 KPA  A 500 (-3.1A)
None
None
None
 1.37A 3lskB-1vb3A:
0.0		 3lskB-1vb3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 SER A 424
PHE A 392
HIS A 404
ASN A 393
 None
 1.29A 3lskB-1xrsA:
undetectable		 3lskB-1xrsA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2

(Carnivore
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 GLN A 468
PHE A 185
HIS A 483
ASN A 485
 None
 1.39A 3lskB-2casA:
undetectable		 3lskB-2casA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		4 GLN A 448
PHE A 474
HIS A 548
ASN A 593
 KBG  A1628 (-3.0A)
KBG  A1628 (-4.7A)
KBG  A1628 (-3.6A)
KBG  A1628 ( 3.8A)
 0.15A 3lskB-2f5vA:
63.5		 3lskB-2f5vA:
99.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lt5 PROTEIN P-30

(Rana pipiens) 		PF00074
(RnaseA) 		4 SER A  87
PHE A  14
PHE A  54
HIS A  58
 None
 1.27A 3lskB-2lt5A:
undetectable		 3lskB-2lt5A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		4 SER A1043
GLN A1099
PHE A1220
HIS A1185
 PEP  A1268 (-3.6A)
PEP  A1268 (-4.0A)
PEP  A1268 (-4.6A)
PEP  A1268 (-4.1A)
 1.26A 3lskB-2nxgA:
undetectable		 3lskB-2nxgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 PHE A 297
PHE A  13
HIS A 323
ASN A 320
 None
 1.08A 3lskB-2oz8A:
undetectable		 3lskB-2oz8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 GLN A 327
PHE A 271
HIS A 242
ASN A 239
 None
None
None
CL  A 335 ( 4.3A)
 1.18A 3lskB-2r3sA:
undetectable		 3lskB-2r3sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 GLN A 750
PHE A 757
HIS A 658
ASN A 695
 None
 0.94A 3lskB-2v5dA:
undetectable		 3lskB-2v5dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 SER A 315
PHE A 135
HIS A 134
ASN A 179
 None
 1.35A 3lskB-2xhyA:
undetectable		 3lskB-2xhyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 GLN A 232
PHE A 250
HIS A 317
ASN A 318
 SO4  A 801 (-3.1A)
None
SO4  A 801 (-4.3A)
SO4  A 801 (-3.8A)
 1.36A 3lskB-2yheA:
undetectable		 3lskB-2yheA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE

(Mycobacterium
gastri) 		PF00215
(OMPdecase) 		4 SER A1162
GLN A1004
PHE A1130
PHE A1057
 None
 1.28A 3lskB-3ajxA:
undetectable		 3lskB-3ajxA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Vibrio cholerae) 		PF00793
(DAHP_synth_1) 		4 SER A  57
GLN A 113
PHE A 237
HIS A 202
 None
None
None
SO4  A 284 ( 4.8A)
 1.34A 3lskB-3e9aA:
undetectable		 3lskB-3e9aA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		4 SER A  59
GLN A 115
PHE A 237
HIS A 202
 None
None
None
PO4  A 278 (-3.8A)
 1.37A 3lskB-3fs2A:
undetectable		 3lskB-3fs2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 GLN A3069
PHE A3043
HIS A3105
ASN A3106
 None
 1.37A 3lskB-3hwcA:
undetectable		 3lskB-3hwcA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 SER A 421
PHE A 450
PHE A 461
ASN A 458
 None
 1.31A 3lskB-3iu1A:
undetectable		 3lskB-3iu1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		4 SER A 385
PHE A 420
PHE A 185
HIS A  88
 CFE  A 513 ( 4.5A)
None
CFE  A 513 ( 3.7A)
CFE  A 513 ( 3.3A)
 1.40A 3lskB-3lggA:
undetectable		 3lskB-3lggA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj8 TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc) 		4 SER A 266
GLN A 336
PHE A 269
PHE A 333
 None
 1.48A 3lskB-3lj8A:
undetectable		 3lskB-3lj8A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pna CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Bos taurus) 		PF00027
(cNMP_binding) 		4 SER A 197
PHE A 172
PHE A 136
ASN A 133
 None
 1.27A 3lskB-3pnaA:
undetectable		 3lskB-3pnaA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		4 SER A 315
PHE A 135
HIS A 134
ASN A 179
 BGC  A 479 ( 3.8A)
None
None
None
 1.36A 3lskB-3qomA:
undetectable		 3lskB-3qomA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		4 PHE A  26
PHE A  36
HIS A 229
ASN A 228
 None
 1.37A 3lskB-3rpcA:
undetectable		 3lskB-3rpcA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		4 SER A  54
GLN A 109
PHE A 222
HIS A 198
 None
CL  A 270 (-3.8A)
CL  A 270 (-4.8A)
CL  A 270 (-4.4A)
 1.30A 3lskB-3stgA:
undetectable		 3lskB-3stgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2

(Burkholderia
pseudomallei) 		PF00793
(DAHP_synth_1) 		4 SER A  55
GLN A 111
PHE A 235
HIS A 200
 NO3  A 283 (-3.0A)
NO3  A 283 (-3.6A)
NO3  A 283 (-4.0A)
A5P  A 282 ( 4.0A)
 1.34A 3lskB-3tmqA:
undetectable		 3lskB-3tmqA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		4 SER A  13
PHE A  92
PHE A  71
HIS A  62
 None
 1.43A 3lskB-3tqrA:
3.7		 3lskB-3tqrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wew HTDX DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 GLN A 113
PHE A  37
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.42A 3lskB-3wewA:
undetectable		 3lskB-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 SER A 421
PHE A 450
PHE A 461
ASN A 458
 None
 1.27A 3lskB-4c2xA:
0.7		 3lskB-4c2xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 GLN A 416
PHE A 322
HIS A 321
ASN A 410
 None
 1.07A 3lskB-4el8A:
undetectable		 3lskB-4el8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		4 SER A 119
GLN A  92
HIS A  57
ASN A 180
 None
 1.31A 3lskB-4f85A:
2.0		 3lskB-4f85A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpn 6-PHOSPHO-BETA-D-GLU
COSIDASE

(Streptococcus
mutans) 		PF00232
(Glyco_hydro_1) 		4 SER A 311
PHE A 131
HIS A 130
ASN A 175
 None
6GB  A 501 ( 4.9A)
6GB  A 501 (-4.3A)
6GB  A 501 (-3.6A)
 1.30A 3lskB-4gpnA:
undetectable		 3lskB-4gpnA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 4 SER A  71
PHE A 158
HIS A 227
ASN A   8
 None
 0.88A 3lskB-4k3zA:
undetectable		 3lskB-4k3zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00106
(adh_short) 		4 SER A 250
PHE A 244
PHE A 258
ASN A 204
 None
 1.23A 3lskB-4kzpA:
3.8		 3lskB-4kzpA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 GLN A 454
PHE A 480
HIS A 553
ASN A 596
 None
None
FDA  A 801 ( 4.8A)
FDA  A 801 (-4.1A)
 0.26A 3lskB-4mifA:
48.0		 3lskB-4mifA:
40.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Bos taurus) 		PF00027
(cNMP_binding) 		4 SER A 197
PHE A 172
PHE A 136
ASN A 133
 None
 1.18A 3lskB-4mx3A:
undetectable		 3lskB-4mx3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		4 GLN A 407
PHE A 313
HIS A 312
ASN A 401
 None
 1.08A 3lskB-4xwlA:
undetectable		 3lskB-4xwlA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens;
Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane)
PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		4 SER A 532
PHE B 556
HIS B 557
ASN A 528
 None
 1.27A 3lskB-5do7A:
undetectable		 3lskB-5do7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 SER A 188
PHE A 103
HIS A 105
ASN A 140
 None
 1.18A 3lskB-5infA:
undetectable		 3lskB-5infA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLN B 870
PHE B1004
PHE B 885
ASN B 853
 None
 0.97A 3lskB-5kyuB:
undetectable		 3lskB-5kyuB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 GLN A 443
PHE A 349
HIS A 348
ASN A 437
 None
 1.11A 3lskB-5yj6A:
undetectable		 3lskB-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 4 SER A 113
GLN A 165
HIS A 268
ASN A 108
 MG  A 603 ( 2.0A)
MG  A 603 (-2.7A)
None
ADP  A 601 (-3.9A)
 1.45A 3lskB-5yv5A:
undetectable		 3lskB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bng 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Acinetobacter
baumannii) 		no annotation 4 SER A  61
GLN A 117
PHE A 239
HIS A 204
 None
SO4  A 301 ( 4.9A)
None
None
 1.41A 3lskB-6bngA:
undetectable		 3lskB-6bngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 SER A1102
GLN A1195
PHE A1231
HIS A1223
 None
 1.18A 3lskB-6fb3A:
undetectable		 3lskB-6fb3A:
undetectable