SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSF_H_PZIH800_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		4 PRO A 164
LEU A 188
ASP A 189
LYS A 209
 None
 1.09A 3lsfH-1m9sA:
undetectable		 3lsfH-1m9sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 TYR A 582
PRO A 557
SER A 500
LEU A 264
 None
 0.82A 3lsfH-1mqsA:
undetectable		 3lsfH-1mqsA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szh HER-1 PROTEIN

(Caenorhabditis
elegans) 		PF09232
(Caenor_Her-1) 		4 TYR A 137
LEU A 123
ASP A 124
LYS A 127
 None
 0.86A 3lsfH-1szhA:
undetectable		 3lsfH-1szhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 PRO A  31
SER A  24
SER A 254
LYS A 276
 None
 1.14A 3lsfH-1tkcA:
undetectable		 3lsfH-1tkcA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		4 TYR A 377
SER A 362
SER A  53
LEU A  56
 None
 1.11A 3lsfH-1w5dA:
undetectable		 3lsfH-1w5dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 TYR A 200
SER A 132
LEU A 154
ASP A 155
 None
 1.10A 3lsfH-1we5A:
undetectable		 3lsfH-1we5A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 TYR B  71
PRO B   9
LEU B 171
ASP B 173
 None
 0.88A 3lsfH-1wqlB:
undetectable		 3lsfH-1wqlB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae) 		PF16755
(NUP214) 		4 TYR A 366
SER A 346
SER A  49
LEU A  64
 None
 1.04A 3lsfH-1xipA:
undetectable		 3lsfH-1xipA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		4 TYR A  39
SER A 112
LEU A 172
ASP A 171
 None
None
None
ZN  A 526 ( 2.9A)
 1.07A 3lsfH-1xocA:
undetectable		 3lsfH-1xocA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypo OXIDISED LOW DENSITY
LIPOPROTEIN
(LECTIN-LIKE)
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		4 PRO A 214
SER A 207
LEU A 206
LYS A 181
 None
 1.10A 3lsfH-1ypoA:
undetectable		 3lsfH-1ypoA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a11 RIBONUCLEASE III

(Mycobacterium
tuberculosis) 		PF14622
(Ribonucleas_3_3) 		4 PRO A   7
SER A   4
LEU A  21
ASP A  18
 None
 1.13A 3lsfH-2a11A:
undetectable		 3lsfH-2a11A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw9 TRANSLOCASE OF INNER
MITOCHONDRIAL
MEMBRANE

(Homo sapiens) 		PF04280
(Tim44) 		4 TYR A 348
LEU A 336
ASP A 337
LYS A 340
 None
 0.86A 3lsfH-2cw9A:
undetectable		 3lsfH-2cw9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7m FILAMIN-C

(Homo sapiens) 		PF00630
(Filamin) 		4 TYR A  82
PRO A 104
SER A  29
ASP A  77
 None
 1.13A 3lsfH-2d7mA:
undetectable		 3lsfH-2d7mA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		4 TYR A  67
PRO A  17
LEU A  40
ASP A  39
 None
 0.98A 3lsfH-2gpyA:
undetectable		 3lsfH-2gpyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		5 TYR A 308
SER A 200
LEU A 203
ASP A 204
LYS A 207
 None
 1.17A 3lsfH-2h39A:
undetectable		 3lsfH-2h39A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 PRO A  15
SER A 189
LEU A 192
ASP A 196
 None
 0.86A 3lsfH-2hk7A:
undetectable		 3lsfH-2hk7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iee PROBABLE ABC
TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YCKB

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		4 TYR A  49
PRO A 106
SER A 232
LEU A 237
 None
 0.76A 3lsfH-2ieeA:
17.3		 3lsfH-2ieeA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 PRO A  31
SER A 220
LEU A 223
ASP A 224
 None
 0.75A 3lsfH-2jfwA:
undetectable		 3lsfH-2jfwA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 SER A 196
SER A 289
LEU A 288
ASP A 140
 None
 0.73A 3lsfH-2ldxA:
undetectable		 3lsfH-2ldxA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 TYR A 244
PRO A  50
SER A  13
ASP A 215
 None
None
None
ZN  A 400 (-3.3A)
 1.12A 3lsfH-2qw5A:
undetectable		 3lsfH-2qw5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra1 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 TYR A 256
LEU A 220
ASP A 221
LYS A 224
 None
 1.09A 3lsfH-2ra1A:
undetectable		 3lsfH-2ra1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 SER A 132
LEU A 135
ASP A 136
LYS A 139
 None
 0.65A 3lsfH-2uxoA:
undetectable		 3lsfH-2uxoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 PRO A 164
LEU A 188
ASP A 189
LYS A 209
 None
 1.00A 3lsfH-2wqwA:
undetectable		 3lsfH-2wqwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 SER A 168
LEU A 188
ASP A 189
LYS A 209
 None
 0.98A 3lsfH-2wqwA:
undetectable		 3lsfH-2wqwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkl APOLIPOPROTEIN M

(Mus musculus) 		PF11032
(ApoM) 		4 SER A 165
SER A 129
LEU A 125
ASP A 124
 None
 0.97A 3lsfH-2xklA:
undetectable		 3lsfH-2xklA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		4 TYR A  74
PRO A 132
LEU A 260
ASP A 271
 None
GOL  A1283 (-4.5A)
None
None
 1.06A 3lsfH-2ylnA:
21.4		 3lsfH-2ylnA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 TYR A 448
PRO A 517
MET A 519
LEU A 776
LYS A 780
 None
 0.33A 3lsfH-2znsA:
37.4		 3lsfH-2znsA:
51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		4 PRO A 214
SER A 175
LEU A 188
ASP A 186
 None
 0.98A 3lsfH-3bfnA:
undetectable		 3lsfH-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 PRO A   9
SER A  36
LEU A  39
ASP A  40
 None
 0.99A 3lsfH-3czeA:
undetectable		 3lsfH-3czeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 344
SER A 232
LEU A 274
ASP A 272
 None
 0.91A 3lsfH-3ddrA:
undetectable		 3lsfH-3ddrA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 TYR A 486
PRO A 395
SER A 399
LEU A 400
 None
 1.14A 3lsfH-3dwkA:
undetectable		 3lsfH-3dwkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		4 TYR A 775
SER A 770
SER A 730
LEU A 733
 None
 1.03A 3lsfH-3ebbA:
undetectable		 3lsfH-3ebbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 TYR A 847
SER A 860
LEU A 814
ASP A 813
 None
None
None
GOL  A2003 (-3.6A)
 1.12A 3lsfH-3ecqA:
undetectable		 3lsfH-3ecqA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		4 PRO D 256
SER D  93
LEU D 340
LYS D 233
 None
 1.03A 3lsfH-3fo8D:
undetectable		 3lsfH-3fo8D:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 TYR A  35
MET A 107
SER A 108
ASP A 248
LYS A 251
 None
None
CYZ  A 265 (-2.8A)
None
CYZ  A 265 ( 4.4A)
 0.86A 3lsfH-3h6tA:
42.7		 3lsfH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		7 TYR A  35
PRO A 105
MET A 107
SER A 108
SER A 242
LEU A 247
LYS A 251
 None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
 0.31A 3lsfH-3h6tA:
42.7		 3lsfH-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 SER A  20
SER A  11
LEU A  10
ASP A   9
 None
 0.88A 3lsfH-3h74A:
undetectable		 3lsfH-3h74A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho6 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		4 SER A 185
SER A 136
LEU A 139
ASP A 140
 None
 0.94A 3lsfH-3ho6A:
undetectable		 3lsfH-3ho6A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 MET A  48
SER A 324
LEU A  50
ASP A  51
 NAG  A5157 ( 3.8A)
None
None
None
 1.08A 3lsfH-3i27A:
undetectable		 3lsfH-3i27A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 TYR A  47
SER A  43
LEU A  66
ASP A  67
 None
NAD  A 501 (-3.4A)
None
None
 1.14A 3lsfH-3jsaA:
undetectable		 3lsfH-3jsaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3p D-ALANINE--D-ALANINE
LIGASE

(Streptococcus
mutans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 PRO A 316
MET A 314
SER A 313
ASP A 289
 None
 0.82A 3lsfH-3k3pA:
undetectable		 3lsfH-3k3pA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		4 PRO A 251
LEU A  13
ASP A  14
LYS A  17
 None
 0.64A 3lsfH-3kgbA:
undetectable		 3lsfH-3kgbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 TYR A 121
MET A 145
SER A 146
SER A 169
 None
 1.01A 3lsfH-3kt4A:
undetectable		 3lsfH-3kt4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0z PUTATIVE ALDOLASE

(Klebsiella
pneumoniae) 		PF07071
(KDGP_aldolase) 		4 PRO A 143
LEU A 150
ASP A 153
LYS A 152
 None
 1.11A 3lsfH-3m0zA:
undetectable		 3lsfH-3m0zA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus;
Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR E  42
SER E 107
SER D 107
LEU D 114
 None
 0.98A 3lsfH-3pqyE:
undetectable		 3lsfH-3pqyE:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 PRO A 312
SER A 321
LEU A 324
ASP A 325
 None
 1.12A 3lsfH-3pt1A:
undetectable		 3lsfH-3pt1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PRO A 169
SER A 171
LEU A 156
ASP A 157
 None
 1.09A 3lsfH-3qnkA:
undetectable		 3lsfH-3qnkA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 105
PRO A 169
SER A 171
LEU A 156
 None
 1.08A 3lsfH-3qnkA:
undetectable		 3lsfH-3qnkA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 143
PRO A 169
LEU A 156
ASP A 157
 None
 0.92A 3lsfH-3qnkA:
undetectable		 3lsfH-3qnkA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 TYR A 431
PRO A 501
MET A 503
LEU A 760
LYS A 764
 None
 0.36A 3lsfH-3qxmA:
37.1		 3lsfH-3qxmA:
51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		4 PRO A 317
SER A 343
LEU A 340
ASP A 339
 None
 1.00A 3lsfH-3t79A:
undetectable		 3lsfH-3t79A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 PRO B 239
MET B 241
SER B 242
LEU B 118
 None
 1.07A 3lsfH-3u0jB:
undetectable		 3lsfH-3u0jB:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 TYR A  35
PRO A 104
MET A 106
LEU A 242
LYS A 246
 None
None
None
None
ZN  A 259 (-3.5A)
 0.42A 3lsfH-3u92A:
36.8		 3lsfH-3u92A:
51.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE

(Staphylococcus
aureus) 		PF01884
(PcrB) 		4 TYR A  58
SER A  53
LEU A  24
ASP A  21
 None
 1.11A 3lsfH-3w01A:
undetectable		 3lsfH-3w01A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 SER A 331
LEU A 334
ASP A 335
LYS A 338
 None
 0.91A 3lsfH-3wnpA:
undetectable		 3lsfH-3wnpA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxo FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		4 TYR A1976
MET A2000
SER A2003
SER A1995
 None
 1.02A 3lsfH-4bxoA:
undetectable		 3lsfH-4bxoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		4 PRO A 249
SER A 171
SER A 238
ASP A 189
 None
 1.10A 3lsfH-4e9kA:
undetectable		 3lsfH-4e9kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		4 SER A  20
SER A 111
LEU A  13
ASP A  12
 None
CIT  A 301 (-2.6A)
CIT  A 301 (-4.2A)
CIT  A 301 ( 2.7A)
 0.98A 3lsfH-4eelA:
undetectable		 3lsfH-4eelA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 TYR A 508
LEU A 524
ASP A 525
LYS A 528
 None
 0.87A 3lsfH-4fyeA:
undetectable		 3lsfH-4fyeA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gri GLUTAMATE--TRNA
LIGASE

(Borreliella
burgdorferi) 		PF00749
(tRNA-synt_1c) 		4 TYR A 348
SER A 376
LEU A 379
LYS A 383
 None
 0.98A 3lsfH-4griA:
undetectable		 3lsfH-4griA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens) 		PF04675
(DNA_ligase_A_N) 		4 PRO A  66
SER A  63
LEU A 221
ASP A 220
 None
 1.08A 3lsfH-4htpA:
undetectable		 3lsfH-4htpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		4 PRO A 371
SER A 373
LEU A 378
LYS A 380
 None
 1.11A 3lsfH-4jp0A:
undetectable		 3lsfH-4jp0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz5 GP26

(Listeria phage
P40) 		PF01183
(Glyco_hydro_25) 		4 PRO A  12
SER A 184
SER A   8
ASP A 187
 None
 1.12A 3lsfH-4jz5A:
undetectable		 3lsfH-4jz5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 PRO A  17
SER A  19
LEU A  24
LYS A  26
 None
 1.05A 3lsfH-4lanA:
undetectable		 3lsfH-4lanA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6w FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		4 TYR A1976
MET A2000
SER A2003
SER A1995
 None
 0.98A 3lsfH-4m6wA:
undetectable		 3lsfH-4m6wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A 132
SER A 107
ASP A  44
LYS A  47
 None
 1.06A 3lsfH-4orbA:
undetectable		 3lsfH-4orbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 PRO A1677
LEU A1566
ASP A1567
LYS A1570
 None
 0.98A 3lsfH-4r04A:
undetectable		 3lsfH-4r04A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 SER A 727
SER A 678
LEU A 681
ASP A 682
 None
 0.89A 3lsfH-4r04A:
undetectable		 3lsfH-4r04A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 SER A1563
LEU A1566
ASP A1567
LYS A1570
 None
 0.79A 3lsfH-4r04A:
undetectable		 3lsfH-4r04A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis) 		PF11477
(PM0188) 		4 SER A 329
SER A   9
LEU A  10
ASP A 114
 None
 1.12A 3lsfH-4v39A:
undetectable		 3lsfH-4v39A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		4 TYR A 517
SER A 506
LEU A 512
ASP A 513
 None
None
None
CA  A 701 ( 4.5A)
 0.88A 3lsfH-4wiwA:
undetectable		 3lsfH-4wiwA:
19.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 TYR A  42
PRO A 112
MET A 114
SER A 248
LEU A 253
 None
 0.53A 3lsfH-4wxjA:
36.8		 3lsfH-4wxjA:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 TYR A 847
SER A 860
LEU A 814
ASP A 813
 None
 1.09A 3lsfH-5a55A:
undetectable		 3lsfH-5a55A:
13.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 TYR A  39
PRO A 109
MET A 111
LEU A 250
LYS A 254
 None
 0.32A 3lsfH-5dtbA:
38.3		 3lsfH-5dtbA:
54.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		4 PRO A 500
LEU A 512
ASP A 513
LYS A 516
 None
 1.10A 3lsfH-5fdnA:
undetectable		 3lsfH-5fdnA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 TYR A 323
PRO A 357
SER A 353
ASP A 348
 None
 1.12A 3lsfH-5ho9A:
undetectable		 3lsfH-5ho9A:
16.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ict GLUTAMATE RECEPTOR 1

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A  40
PRO A 111
MET A 113
LEU A 252
 None
 0.27A 3lsfH-5ictA:
39.5		 3lsfH-5ictA:
55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 PRO A 104
MET A 106
LEU A 243
LYS A 247
 None
 0.34A 3lsfH-5ikbA:
36.3		 3lsfH-5ikbA:
54.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsn BCL2 INHIBITOR

(unidentified) 		no annotation 4 SER B  83
LEU B  86
ASP B  87
LYS B  90
 None
 0.85A 3lsfH-5jsnB:
undetectable		 3lsfH-5jsnB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 431
PRO A 501
MET A 503
LEU A 760
LYS A 764
 None
 0.95A 3lsfH-5kufA:
34.4		 3lsfH-5kufA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		8 TYR A 424
PRO A 494
MET A 496
SER A 497
SER A 754
LEU A 759
ASP A 760
LYS A 763
 None
 0.56A 3lsfH-5l1bA:
22.1		 3lsfH-5l1bA:
70.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lef KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		no annotation 4 SER C 607
LEU C 610
ASP C 611
LYS C 614
 None
 0.80A 3lsfH-5lefC:
undetectable		 3lsfH-5lefC:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 RETICULOCYTE
BINDING-LIKE PROTEIN
5,RETICULOCYTE
BINDING PROTEIN 5

(Plasmodium
falciparum) 		no annotation 4 TYR A 184
LEU A 460
ASP A 461
LYS A 464
 None
 0.96A 3lsfH-5mi0A:
undetectable		 3lsfH-5mi0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR A 102
MET A  90
SER A 134
LEU A 136
 None
 1.07A 3lsfH-5olsA:
undetectable		 3lsfH-5olsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION
CONTROL PROTEIN 6

(Saccharomyces
cerevisiae) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 TYR 9 105
PRO 9 109
ASP 9 266
LYS 9 268
 None
AGS  92001 (-4.5A)
None
None
 0.91A 3lsfH-5udb9:
undetectable		 3lsfH-5udb9:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 TYR A 533
SER A 777
SER A 528
LYS A 532
 None
 1.10A 3lsfH-5uowA:
27.0		 3lsfH-5uowA:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		7 TYR A 424
PRO A 494
MET A 496
SER A 497
SER A 754
LEU A 759
ASP A 760
 None
 0.71A 3lsfH-5welA:
32.1		 3lsfH-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		7 TYR A 424
PRO A 494
MET A 496
SER A 497
SER A 754
LEU A 759
LYS A 763
 None
 0.79A 3lsfH-5welA:
32.1		 3lsfH-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
MET A 496
SER A 497
LEU A 759
ASP A 760
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 (-3.8A)
 0.68A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
MET A 496
SER A 497
LEU A 759
LYS A 763
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 (-2.9A)
 1.05A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
MET A 496
SER A 754
LEU A 759
ASP A 760
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 ( 4.1A)
None
CYZ  A1302 (-3.8A)
 0.83A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
MET A 496
SER A 754
LEU A 759
LYS A 763
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 ( 4.1A)
None
CYZ  A1302 (-2.9A)
 1.02A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
PRO A 494
MET A 496
SER A 497
ASP A 760
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
CYZ  A1302 (-3.8A)
 0.83A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
PRO A 494
MET A 496
SER A 497
LYS A 763
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
CYZ  A1302 (-2.9A)
 1.02A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
PRO A 494
MET A 496
SER A 754
ASP A 760
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 ( 4.1A)
CYZ  A1302 (-3.8A)
 0.98A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 424
PRO A 494
MET A 496
SER A 754
LYS A 763
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 ( 4.1A)
CYZ  A1302 (-2.9A)
 1.08A 3lsfH-5weoA:
24.6		 3lsfH-5weoA:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 4 MET A 328
SER A 408
SER A 317
LEU A 323
 None
 1.06A 3lsfH-5wpwA:
undetectable		 3lsfH-5wpwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk2 DIACYLGLYCEROL
LIPASE

(Aspergillus
oryzae) 		no annotation 4 TYR A 226
PRO A 207
SER A 267
SER A 256
 None
 1.07A 3lsfH-5xk2A:
undetectable		 3lsfH-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj MRNA
3'-END-PROCESSING
PROTEIN YTH1

(Saccharomyces
cerevisiae) 		no annotation 4 PRO B  17
SER B  26
LEU B  27
ASP B  28
 None
 1.09A 3lsfH-6eojB:
undetectable		 3lsfH-6eojB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 TYR A 104
SER A  93
LEU A  96
ASP A  97
 None
 0.92A 3lsfH-6fwfA:
undetectable		 3lsfH-6fwfA:
undetectable