SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSF_E_PZIE802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
3 ASP A2809
ASN A2811
SER A2676
None
0.89A 3lsfB-1js8A:
0.0
3lsfE-1js8A:
undetectable
3lsfB-1js8A:
21.57
3lsfE-1js8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR


(Escherichia
coli)
PF13377
(Peripla_BP_3)
3 ASP A 149
ASN A 125
SER A 191
None
0.92A 3lsfB-1jyeA:
2.4
3lsfE-1jyeA:
3.1
3lsfB-1jyeA:
22.56
3lsfE-1jyeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR


(Escherichia
coli)
PF13377
(Peripla_BP_3)
3 ASP A 149
ASN A 125
SER A 193
None
None
GOL  A 350 ( 4.3A)
0.99A 3lsfB-1jyeA:
2.4
3lsfE-1jyeA:
3.1
3lsfB-1jyeA:
22.56
3lsfE-1jyeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens)
PF00151
(Lipase)
PF01477
(PLAT)
3 ASP B 272
ASN B  92
SER B 333
None
None
BOG  B 452 (-3.5A)
0.99A 3lsfB-1lpbB:
0.0
3lsfE-1lpbB:
0.0
3lsfB-1lpbB:
18.93
3lsfE-1lpbB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m58 RC-RNASE2
RIBONUCLEASE


(Rana
catesbeiana)
PF00074
(RnaseA)
3 ASP A  68
ASN A  70
SER A  83
None
1.01A 3lsfB-1m58A:
undetectable
3lsfE-1m58A:
undetectable
3lsfB-1m58A:
17.48
3lsfE-1m58A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)


(Caenorhabditis
elegans)
PF01633
(Choline_kinase)
3 ASP A 255
ASN A 316
SER A  86
None
0.81A 3lsfB-1nw1A:
0.0
3lsfE-1nw1A:
0.0
3lsfB-1nw1A:
19.36
3lsfE-1nw1A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Thermotoga
maritima)
PF01979
(Amidohydro_1)
3 ASP A 229
ASN A 301
SER A 291
None
0.92A 3lsfB-1o12A:
0.0
3lsfE-1o12A:
undetectable
3lsfB-1o12A:
22.79
3lsfE-1o12A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album)
PF00082
(Peptidase_S8)
3 ASP E 165
ASN E 168
SER E 197
None
0.89A 3lsfB-1pekE:
0.4
3lsfE-1pekE:
undetectable
3lsfB-1pekE:
21.14
3lsfE-1pekE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1


(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 ASP A 318
ASN A 299
SER A 336
None
1.01A 3lsfB-1pguA:
undetectable
3lsfE-1pguA:
undetectable
3lsfB-1pguA:
18.20
3lsfE-1pguA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd6 PROTEIN (OUTER
MEMBRANE
PHOSPHOLIPASE
(OMPLA))


(Escherichia
coli)
PF02253
(PLA1)
3 ASP C 267
ASN C 266
SER C 209
None
0.99A 3lsfB-1qd6C:
undetectable
3lsfE-1qd6C:
undetectable
3lsfB-1qd6C:
22.73
3lsfE-1qd6C:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td0 HEAD DECORATION
PROTEIN


(Escherichia
virus Lambda)
PF02924
(HDPD)
3 ASP A  19
ASN A  18
SER A 109
None
1.00A 3lsfB-1td0A:
undetectable
3lsfE-1td0A:
undetectable
3lsfB-1td0A:
20.48
3lsfE-1td0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli)
PF13377
(Peripla_BP_3)
3 ASP A 149
ASN A 125
SER A 191
IPT  A 998 (-3.2A)
IPT  A 998 ( 4.7A)
IPT  A 998 ( 4.6A)
0.89A 3lsfB-1tlfA:
undetectable
3lsfE-1tlfA:
3.5
3lsfB-1tlfA:
23.65
3lsfE-1tlfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toc ORNITHODORIN

(Ornithodoros
moubata)
no annotation 3 ASP R  16
ASN R  14
SER R  37
None
0.64A 3lsfB-1tocR:
undetectable
3lsfE-1tocR:
undetectable
3lsfB-1tocR:
16.06
3lsfE-1tocR:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE


(Escherichia
coli)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
3 ASP A 317
ASN A 316
SER A 325
None
None
SO4  A 964 ( 4.9A)
0.82A 3lsfB-1uagA:
undetectable
3lsfE-1uagA:
undetectable
3lsfB-1uagA:
21.36
3lsfE-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT


(Rhodococcus
jostii)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 ASP A 377
ASN A 381
SER A 232
None
1.02A 3lsfB-1uliA:
undetectable
3lsfE-1uliA:
undetectable
3lsfB-1uliA:
19.39
3lsfE-1uliA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE


(Thermotoga
maritima)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
3 ASP A  72
ASN A 261
SER A  75
None
1.02A 3lsfB-1wopA:
undetectable
3lsfE-1wopA:
undetectable
3lsfB-1wopA:
24.93
3lsfE-1wopA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE


(Bacillus
anthracis)
PF03497
(Anthrax_toxA)
PF07737
(ATLF)
3 ASP A 406
ASN A 451
SER A 341
None
0.99A 3lsfB-1xfuA:
undetectable
3lsfE-1xfuA:
undetectable
3lsfB-1xfuA:
15.78
3lsfE-1xfuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1


(Rattus
norvegicus)
PF01661
(Macro)
3 ASP A 191
ASN A 193
SER A 156
None
0.68A 3lsfB-1yd9A:
undetectable
3lsfE-1yd9A:
undetectable
3lsfB-1yd9A:
20.52
3lsfE-1yd9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima)
PF02065
(Melibiase)
3 ASP A 494
ASN A 516
SER A 492
None
0.99A 3lsfB-1zy9A:
undetectable
3lsfE-1zy9A:
undetectable
3lsfB-1zy9A:
20.22
3lsfE-1zy9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE


(Vespula
vulgaris)
PF01630
(Glyco_hydro_56)
3 ASP A  45
ASN A  97
SER A  38
None
1.02A 3lsfB-2atmA:
undetectable
3lsfE-2atmA:
undetectable
3lsfB-2atmA:
21.08
3lsfE-2atmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE


(Streptococcus
pyogenes)
PF09028
(Mac-1)
3 ASP A  81
ASN A 101
SER A 287
None
1.02A 3lsfB-2au1A:
undetectable
3lsfE-2au1A:
undetectable
3lsfB-2au1A:
21.26
3lsfE-2au1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
3 ASP A 134
ASN A 150
SER A 154
None
0.96A 3lsfB-2c4kA:
undetectable
3lsfE-2c4kA:
undetectable
3lsfB-2c4kA:
21.98
3lsfE-2c4kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00180
(Iso_dh)
3 ASP A 442
ASN A 399
SER A 154
None
0.92A 3lsfB-2d1cA:
undetectable
3lsfE-2d1cA:
undetectable
3lsfB-2d1cA:
19.68
3lsfE-2d1cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN


(Daboia
siamensis)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
3 ASP A  66
ASN A  69
SER A  22
None
NAG  A 900 ( 2.0A)
None
0.92A 3lsfB-2e3xA:
undetectable
3lsfE-2e3xA:
undetectable
3lsfB-2e3xA:
18.79
3lsfE-2e3xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4


(Escherichia
coli)
PF02113
(Peptidase_S13)
3 ASP A 381
ASN A 382
SER A 388
None
0.99A 3lsfB-2exaA:
undetectable
3lsfE-2exaA:
undetectable
3lsfB-2exaA:
20.48
3lsfE-2exaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
3 ASP A 666
ASN A 594
SER A 773
None
0.82A 3lsfB-2f3oA:
undetectable
3lsfE-2f3oA:
undetectable
3lsfB-2f3oA:
17.65
3lsfE-2f3oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsb RAS
GTPASE-ACTIVATING
PROTEIN 1


(Homo sapiens)
PF00017
(SH2)
3 ASP A  47
ASN A  48
SER A  24
None
0.95A 3lsfB-2gsbA:
undetectable
3lsfE-2gsbA:
undetectable
3lsfB-2gsbA:
18.52
3lsfE-2gsbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP


(Vibrio harveyi)
PF13407
(Peripla_BP_4)
3 ASP A 136
ASN A 159
SER A 207
None
AI2  A 501 (-3.3A)
None
0.99A 3lsfB-2hj9A:
3.2
3lsfE-2hj9A:
2.6
3lsfB-2hj9A:
20.11
3lsfE-2hj9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Escherichia
coli)
PF01979
(Amidohydro_1)
3 ASP A 248
ASN A 319
SER A 309
None
0.88A 3lsfB-2p50A:
undetectable
3lsfE-2p50A:
undetectable
3lsfB-2p50A:
21.14
3lsfE-2p50A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae)
PF04097
(Nic96)
3 ASP A 419
ASN A 395
SER A 421
None
0.86A 3lsfB-2rfoA:
undetectable
3lsfE-2rfoA:
undetectable
3lsfB-2rfoA:
17.21
3lsfE-2rfoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum)
PF00245
(Alk_phosphatase)
3 ASP A 261
ASN A 268
SER A 375
None
0.84A 3lsfB-2x98A:
undetectable
3lsfE-2x98A:
undetectable
3lsfB-2x98A:
19.03
3lsfE-2x98A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckm YRAM (HI1655)

(Haemophilus
influenzae)
PF04348
(LppC)
3 ASP A 559
ASN A 371
SER A 549
None
1.00A 3lsfB-3ckmA:
undetectable
3lsfE-3ckmA:
undetectable
3lsfB-3ckmA:
19.94
3lsfE-3ckmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR


(Lactobacillus
plantarum)
PF13377
(Peripla_BP_3)
3 ASP A 247
ASN A  74
SER A 288
None
0.97A 3lsfB-3clkA:
undetectable
3lsfE-3clkA:
2.7
3lsfB-3clkA:
22.87
3lsfE-3clkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6i MONOTHIOL
GLUTAREDOXIN-3


(Saccharomyces
cerevisiae)
PF00085
(Thioredoxin)
3 ASP A  97
ASN A  42
SER A  67
None
0.99A 3lsfB-3d6iA:
undetectable
3lsfE-3d6iA:
undetectable
3lsfB-3d6iA:
17.06
3lsfE-3d6iA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus)
PF07859
(Abhydrolase_3)
3 ASP A 184
ASN A 230
SER A 188
None
0.86A 3lsfB-3d7rA:
undetectable
3lsfE-3d7rA:
undetectable
3lsfB-3d7rA:
18.60
3lsfE-3d7rA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Vibrio cholerae)
PF01979
(Amidohydro_1)
3 ASP A 245
ASN A 316
SER A 306
None
0.83A 3lsfB-3egjA:
undetectable
3lsfE-3egjA:
undetectable
3lsfB-3egjA:
23.51
3lsfE-3egjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 ASP A 121
ASN A 124
SER A  57
None
NAG  A 521 (-2.9A)
None
0.91A 3lsfB-3fw8A:
undetectable
3lsfE-3fw8A:
undetectable
3lsfB-3fw8A:
21.41
3lsfE-3fw8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus)
PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
3 ASP A 487
ASN A 484
SER A  86
None
0.99A 3lsfB-3h7lA:
undetectable
3lsfE-3h7lA:
undetectable
3lsfB-3h7lA:
16.84
3lsfE-3h7lA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA


(Moorella
thermoacetica;
Moorella
thermoacetica)
PF03063
(Prismane)
PF03598
(CdhC)
3 ASP A 226
ASN A 225
SER M  34
None
0.94A 3lsfB-3i04A:
undetectable
3lsfE-3i04A:
undetectable
3lsfB-3i04A:
17.23
3lsfE-3i04A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A


(Salmonella
enterica)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
3 ASP A 113
ASN A 188
SER A 115
None
0.91A 3lsfB-3i12A:
undetectable
3lsfE-3i12A:
undetectable
3lsfB-3i12A:
21.99
3lsfE-3i12A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A


(Salmonella
enterica)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
3 ASP A 263
ASN A 264
SER A 326
None
0.94A 3lsfB-3i12A:
undetectable
3lsfE-3i12A:
undetectable
3lsfB-3i12A:
21.99
3lsfE-3i12A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21


(Homo sapiens)
PF00443
(UCH)
3 ASP A 352
ASN A 356
SER A 494
None
0.81A 3lsfB-3i3tA:
undetectable
3lsfE-3i3tA:
undetectable
3lsfB-3i3tA:
21.01
3lsfE-3i3tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4


(Thermus
thermophilus)
PF00346
(Complex1_49kDa)
3 ASP 4 401
ASN 4 377
SER 4 128
None
0.94A 3lsfB-3i9v4:
undetectable
3lsfE-3i9v4:
undetectable
3lsfB-3i9v4:
20.62
3lsfE-3i9v4:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus)
PF00901
(Orbi_VP5)
3 ASP D 472
ASN D 476
SER D 305
None
0.37A 3lsfB-3j9eD:
undetectable
3lsfE-3j9eD:
undetectable
3lsfB-3j9eD:
19.08
3lsfE-3j9eD:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF14


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF01423
(LSM)
3 ASP A  81
ASN e  87
SER A 509
None
G  C  75 ( 4.7A)
None
0.92A 3lsfB-3jb9A:
undetectable
3lsfE-3jb9A:
undetectable
3lsfB-3jb9A:
7.59
3lsfE-3jb9A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN


(Homo sapiens)
PF00516
(GP120)
3 ASP A 457
ASN A 462
SER A 365
None
0.85A 3lsfB-3jwoA:
undetectable
3lsfE-3jwoA:
undetectable
3lsfB-3jwoA:
20.38
3lsfE-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
3 ASP A 102
ASN A 105
SER A 210
None
0.79A 3lsfB-3lhxA:
undetectable
3lsfE-3lhxA:
undetectable
3lsfB-3lhxA:
22.33
3lsfE-3lhxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz1 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Sinorhizobium
meliloti)
PF03466
(LysR_substrate)
3 ASP A 123
ASN A 218
SER A  94
None
0.82A 3lsfB-3mz1A:
7.9
3lsfE-3mz1A:
7.7
3lsfB-3mz1A:
21.54
3lsfE-3mz1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE


(Methylobacillus
flagellatus)
PF14403
(CP_ATPgrasp_2)
3 ASP A 321
ASN A 123
SER A 349
None
0.93A 3lsfB-3n6xA:
undetectable
3lsfE-3n6xA:
undetectable
3lsfB-3n6xA:
19.67
3lsfE-3n6xA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE


(Clostridioides
difficile)
PF06050
(HGD-D)
3 ASP B 352
ASN B 358
SER B  73
None
1.02A 3lsfB-3o3mB:
undetectable
3lsfE-3o3mB:
undetectable
3lsfB-3o3mB:
19.90
3lsfE-3o3mB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN


(Enterococcus
faecalis)
PF00496
(SBP_bac_5)
3 ASP A 466
ASN A 472
SER A 492
None
0.84A 3lsfB-3o6pA:
undetectable
3lsfE-3o6pA:
1.4
3lsfB-3o6pA:
21.37
3lsfE-3o6pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN


(Homo sapiens)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
3 ASP B 491
ASN B 515
SER B 232
None
0.82A 3lsfB-3ojyB:
undetectable
3lsfE-3ojyB:
undetectable
3lsfB-3ojyB:
19.72
3lsfE-3ojyB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyo HEMOPEXIN FOLD
PROTEIN CP4


(Vigna
unguiculata)
PF00045
(Hemopexin)
3 ASP A  65
ASN A   7
SER A 119
None
CA  A 228 (-3.5A)
None
1.01A 3lsfB-3oyoA:
undetectable
3lsfE-3oyoA:
undetectable
3lsfB-3oyoA:
23.96
3lsfE-3oyoA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE


(Bordetella
bronchiseptica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ASP A 308
ASN A 335
SER A  51
None
0.96A 3lsfB-3ozyA:
undetectable
3lsfE-3ozyA:
undetectable
3lsfB-3ozyA:
21.35
3lsfE-3ozyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 ASP A 141
ASN A 195
SER A 313
None
0.95A 3lsfB-3p5pA:
undetectable
3lsfE-3p5pA:
undetectable
3lsfB-3p5pA:
15.02
3lsfE-3p5pA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY


(Francisella
philomiragia)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ASP A 321
ASN A 267
SER A 137
None
0.96A 3lsfB-3r11A:
undetectable
3lsfE-3r11A:
undetectable
3lsfB-3r11A:
20.68
3lsfE-3r11A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE


(Abies grandis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 ASP A 472
ASN A 487
SER A 124
None
0.98A 3lsfB-3sdqA:
undetectable
3lsfE-3sdqA:
undetectable
3lsfB-3sdqA:
15.02
3lsfE-3sdqA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE
CASPASE


(Drosophila
melanogaster;
Drosophila
melanogaster)
PF00656
(Peptidase_C14)
PF00656
(Peptidase_C14)
3 ASP A  45
ASN A  27
SER B 192
None
0.96A 3lsfB-3sipA:
undetectable
3lsfE-3sipA:
undetectable
3lsfB-3sipA:
19.62
3lsfE-3sipA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3


(Homo sapiens)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III)
3 ASP B 398
ASN B 376
SER B 403
None
1.02A 3lsfB-3thwB:
undetectable
3lsfE-3thwB:
undetectable
3lsfB-3thwB:
14.68
3lsfE-3thwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyg ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
3 ASP A  27
ASN A  83
SER A 154
None
0.93A 3lsfB-3tygA:
undetectable
3lsfE-3tygA:
undetectable
3lsfB-3tygA:
20.08
3lsfE-3tygA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN


(Thermus
thermophilus)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
3 ASP D 259
ASN D 262
SER D 156
None
0.74A 3lsfB-3w3aD:
undetectable
3lsfE-3w3aD:
undetectable
3lsfB-3w3aD:
20.52
3lsfE-3w3aD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
3 ASP A 239
ASN A  59
SER A 218
None
1.01A 3lsfB-4ainA:
undetectable
3lsfE-4ainA:
undetectable
3lsfB-4ainA:
19.67
3lsfE-4ainA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 3 ASP A 192
ASN A 196
SER A 224
None
0.81A 3lsfB-4bb9A:
undetectable
3lsfE-4bb9A:
undetectable
3lsfB-4bb9A:
17.34
3lsfE-4bb9A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL38

(Sus scrofa)
no annotation 3 ASP b 222
ASN b 220
SER b 263
None
0.79A 3lsfB-4ce4b:
undetectable
3lsfE-4ce4b:
undetectable
3lsfB-4ce4b:
18.05
3lsfE-4ce4b:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE


(Pseudomonas
aeruginosa)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 ASP A 230
ASN A 231
SER A 239
None
1.01A 3lsfB-4cw4A:
undetectable
3lsfE-4cw4A:
undetectable
3lsfB-4cw4A:
17.69
3lsfE-4cw4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN


(Helicobacter
pylori)
no annotation 3 ASP A 787
ASN A 791
SER A 689
None
0.81A 3lsfB-4dvzA:
undetectable
3lsfE-4dvzA:
undetectable
3lsfB-4dvzA:
20.25
3lsfE-4dvzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL


(Rhodopseudomonas
palustris)
PF13458
(Peripla_BP_6)
3 ASP A 259
ASN A 263
SER A 279
None
0.99A 3lsfB-4eygA:
undetectable
3lsfE-4eygA:
undetectable
3lsfB-4eygA:
23.02
3lsfE-4eygA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
3 ASP A 806
ASN A 807
SER A 841
None
0.88A 3lsfB-4fddA:
undetectable
3lsfE-4fddA:
undetectable
3lsfB-4fddA:
14.22
3lsfE-4fddA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE


(Pseudomonas
aeruginosa)
PF03573
(OprD)
3 ASP A 311
ASN A 164
SER A 179
None
0.94A 3lsfB-4frxA:
undetectable
3lsfE-4frxA:
undetectable
3lsfB-4frxA:
19.91
3lsfE-4frxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ASP A 144
ASN A 142
SER A  17
None
0.96A 3lsfB-4h19A:
undetectable
3lsfE-4h19A:
undetectable
3lsfB-4h19A:
23.06
3lsfE-4h19A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz9 PUTATIVE CYTOPLASMIC
PROTEIN


(Ralstonia
pickettii)
no annotation 3 ASP A  86
ASN A   9
SER A  88
None
0.96A 3lsfB-4hz9A:
undetectable
3lsfE-4hz9A:
undetectable
3lsfB-4hz9A:
17.96
3lsfE-4hz9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN


(Adineta vaga)
PF00497
(SBP_bac_3)
3 ASP A  85
ASN A 105
SER A  17
MET  A 301 (-4.7A)
MET  A 301 ( 4.9A)
None
0.80A 3lsfB-4io6A:
27.5
3lsfE-4io6A:
27.7
3lsfB-4io6A:
28.83
3lsfE-4io6A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
3 ASP A1176
ASN A1170
SER A1142
None
0.89A 3lsfB-4pj3A:
undetectable
3lsfE-4pj3A:
undetectable
3lsfB-4pj3A:
10.71
3lsfE-4pj3A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus)
no annotation 3 ASP A  72
ASN A  71
SER A  44
None
1.02A 3lsfB-4qanA:
undetectable
3lsfE-4qanA:
undetectable
3lsfB-4qanA:
22.38
3lsfE-4qanA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum)
PF00704
(Glyco_hydro_18)
3 ASP A 382
ASN A  21
SER A 331
None
0.67A 3lsfB-4tx8A:
undetectable
3lsfE-4tx8A:
undetectable
3lsfB-4tx8A:
18.84
3lsfE-4tx8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7


(Homo sapiens)
PF03133
(TTL)
3 ASP A 223
ASN A 453
SER A 273
None
0.91A 3lsfB-4ylrA:
undetectable
3lsfE-4ylrA:
undetectable
3lsfB-4ylrA:
20.78
3lsfE-4ylrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqu CDII TOXIN

(Salmonella
enterica)
PF07262
(CdiI)
3 ASP B 121
ASN B  30
SER B 119
None
0.95A 3lsfB-4zquB:
undetectable
3lsfE-4zquB:
undetectable
3lsfB-4zquB:
21.97
3lsfE-4zquB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7x HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
3 ASP A 457
ASN A 280
SER A 365
None
0.92A 3lsfB-5a7xA:
undetectable
3lsfE-5a7xA:
undetectable
3lsfB-5a7xA:
22.26
3lsfE-5a7xA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c78 ATP-DRIVEN FLIPPASE
PGLK


(Campylobacter
jejuni)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 ASP A 509
ASN A 431
SER A 389
None
0.84A 3lsfB-5c78A:
undetectable
3lsfE-5c78A:
undetectable
3lsfB-5c78A:
18.95
3lsfE-5c78A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP1
VP3


(Cardiovirus B;
Cardiovirus B)
no annotation
PF00073
(Rhv)
3 ASP A   3
ASN B 156
SER A  11
None
1.01A 3lsfB-5cfcA:
undetectable
3lsfE-5cfcA:
undetectable
3lsfB-5cfcA:
20.49
3lsfE-5cfcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli)
PF01212
(Beta_elim_lyase)
3 ASP A 324
ASN A 327
SER A  62
None
1.02A 3lsfB-5d8gA:
undetectable
3lsfE-5d8gA:
undetectable
3lsfB-5d8gA:
20.97
3lsfE-5d8gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM


(Salmonella
enterica)
PF00884
(Sulfatase)
PF11893
(DUF3413)
3 ASP A 303
ASN A 304
SER A 351
None
0.95A 3lsfB-5i5dA:
undetectable
3lsfE-5i5dA:
undetectable
3lsfB-5i5dA:
16.70
3lsfE-5i5dA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibv CAPSID POLYPROTEIN
VP90


(Mamastrovirus 1)
PF03115
(Astro_capsid_N)
3 ASP A 321
ASN A 408
SER A 310
None
0.65A 3lsfB-5ibvA:
undetectable
3lsfE-5ibvA:
undetectable
3lsfB-5ibvA:
21.36
3lsfE-5ibvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD


(Pseudomonas
aeruginosa)
PF04453
(OstA_C)
3 ASP A 480
ASN A 478
SER A 380
None
0.90A 3lsfB-5ivaA:
undetectable
3lsfE-5ivaA:
undetectable
3lsfB-5ivaA:
19.04
3lsfE-5ivaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD


(Pseudomonas
aeruginosa)
PF04453
(OstA_C)
3 ASP A 480
ASN A 478
SER A 492
None
1.02A 3lsfB-5ivaA:
undetectable
3lsfE-5ivaA:
undetectable
3lsfB-5ivaA:
19.04
3lsfE-5ivaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE


(Rhizobium
leguminosarum)
PF00920
(ILVD_EDD)
3 ASP A 142
ASN A 572
SER A 255
None
0.99A 3lsfB-5j84A:
1.0
3lsfE-5j84A:
undetectable
3lsfB-5j84A:
18.38
3lsfE-5j84A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N)
3 ASP A 435
ASN A 436
SER A 354
None
0.87A 3lsfB-5jmdA:
undetectable
3lsfE-5jmdA:
undetectable
3lsfB-5jmdA:
16.85
3lsfE-5jmdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa)
PF13402
(Peptidase_M60)
3 ASP A 649
ASN A 825
SER A 652
None
0.87A 3lsfB-5kdxA:
undetectable
3lsfE-5kdxA:
undetectable
3lsfB-5kdxA:
14.07
3lsfE-5kdxA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812)
no annotation 3 ASP A 401
ASN A 406
SER A  78
None
0.99A 3lsfB-5li4A:
undetectable
3lsfE-5li4A:
undetectable
3lsfB-5li4A:
20.04
3lsfE-5li4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


(Escherichia
coli)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
3 ASP A 562
ASN A 681
SER A 557
None
0.98A 3lsfB-5ljoA:
undetectable
3lsfE-5ljoA:
undetectable
3lsfB-5ljoA:
15.79
3lsfE-5ljoA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkn NEURAL CELL ADHESION
MOLECULE 1


(Homo sapiens)
PF00041
(fn3)
3 ASP A 664
ASN A 666
SER A 643
None
0.89A 3lsfB-5lknA:
undetectable
3lsfE-5lknA:
undetectable
3lsfB-5lknA:
15.12
3lsfE-5lknA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE


(Thermocrispum
municipale)
PF07992
(Pyr_redox_2)
3 ASP A  59
ASN A 277
SER A 188
NAP  A 602 ( 2.9A)
None
NAP  A 602 (-4.1A)
0.94A 3lsfB-5m10A:
undetectable
3lsfE-5m10A:
undetectable
3lsfB-5m10A:
20.15
3lsfE-5m10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum)
PF00400
(WD40)
3 ASP A  22
ASN A 544
SER A  34
None
0.82A 3lsfB-5tqrA:
undetectable
3lsfE-5tqrA:
undetectable
3lsfB-5tqrA:
19.34
3lsfE-5tqrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47


(Homo sapiens;
Homo sapiens;
Human
alphaherpesvirus
1)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF05363
(Herpes_US12)
3 ASP X   9
ASN B 269
SER A 412
None
0.95A 3lsfB-5u1dX:
undetectable
3lsfE-5u1dX:
undetectable
3lsfB-5u1dX:
18.91
3lsfE-5u1dX:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10)
no annotation 3 ASP A  73
ASN A  75
SER A  61
None
0.93A 3lsfB-5uytA:
undetectable
3lsfE-5uytA:
undetectable
3lsfB-5uytA:
18.93
3lsfE-5uytA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
no annotation 3 ASP G 457
ASN G 280
SER G 365
None
0.97A 3lsfB-5wduG:
undetectable
3lsfE-5wduG:
undetectable
3lsfB-5wduG:
undetectable
3lsfE-5wduG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT


(Diaphorobacter
sp. DS2)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 ASP A 359
ASN A 363
SER A 213
None
1.00A 3lsfB-5xbpA:
undetectable
3lsfE-5xbpA:
undetectable
3lsfB-5xbpA:
21.48
3lsfE-5xbpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium)
no annotation 3 ASP A 169
ASN A 172
SER A 201
None
0.97A 3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable
3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbp DH270.6 SINGLE CHAIN
VARIABLE FRAGMENT
MAN9-V3 GLYCOPEPTIDE


(Homo sapiens;
Human
immunodeficiency
virus 1)
no annotation
no annotation
3 ASP A 107
ASN P 300
SER A 109
None
1.01A 3lsfB-6cbpA:
undetectable
3lsfE-6cbpA:
undetectable
3lsfB-6cbpA:
undetectable
3lsfE-6cbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C


(Homo sapiens)
no annotation 3 ASP B 546
ASN B 565
SER B 527
None
0.93A 3lsfB-6es1B:
undetectable
3lsfE-6es1B:
undetectable
3lsfB-6es1B:
undetectable
3lsfE-6es1B:
undetectable