SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSF_E_PZIE800

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 PRO A 180
SER A 174
GLY A 178
PRO A 149
ASP A 235
 None
NDP  A 302 (-2.6A)
None
None
None
 1.23A 3lsfB-1a4iA:
0.0
3lsfE-1a4iA:
0.0		 3lsfB-1a4iA:
22.19
3lsfE-1a4iA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 PRO A 225
SER A 188
GLY A 196
MET A 228
LYS A 295
 None
None
None
None
MTL  A5600 (-2.8A)
 1.44A 3lsfB-1m2wA:
0.0
3lsfE-1m2wA:
undetectable		 3lsfB-1m2wA:
18.79
3lsfE-1m2wA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u78 TRANSPOSABLE ELEMENT
TC3 TRANSPOSASE

(Caenorhabditis
elegans) 		PF01498
(HTH_Tnp_Tc3_2)
PF11427
(HTH_Tnp_Tc3_1) 		5 SER A  48
GLY A  50
LEU A  15
ASP A  16
LYS A  19
 None
 1.07A 3lsfB-1u78A:
undetectable
3lsfE-1u78A:
undetectable		 3lsfB-1u78A:
19.10
3lsfE-1u78A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcy PYRROLINE
CARBOXYLATE
REDUCTASE

(Plasmodium
falciparum) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 PRO A 170
SER A 166
GLY A 167
PRO A 117
LEU A  19
 None
None
NAP  A 264 ( 4.8A)
None
None
 1.39A 3lsfB-2rcyA:
undetectable
3lsfE-2rcyA:
undetectable		 3lsfB-2rcyA:
24.57
3lsfE-2rcyA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcy PYRROLINE
CARBOXYLATE
REDUCTASE

(Plasmodium
falciparum) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 PRO A 170
SER A 166
GLY A 167
PRO A 117
SER A 124
 None
None
NAP  A 264 ( 4.8A)
None
None
 1.26A 3lsfB-2rcyA:
undetectable
3lsfE-2rcyA:
undetectable		 3lsfB-2rcyA:
24.57
3lsfE-2rcyA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PRO A 969
SER A 513
MET A 711
SER A 709
ASP A 328
 None
 1.36A 3lsfB-2vdcA:
0.0
3lsfE-2vdcA:
0.3		 3lsfB-2vdcA:
10.64
3lsfE-2vdcA:
10.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		6 PRO A 105
MET A 107
SER A 108
SER A 242
LEU A 247
LYS A 251
 CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
 0.30A 3lsfB-3h6tA:
43.6
3lsfE-3h6tA:
43.0		 3lsfB-3h6tA:
100.00
3lsfE-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		5 GLY A 258
SER A  20
SER A  11
LEU A  10
ASP A   9
 None
 1.07A 3lsfB-3h74A:
0.0
3lsfE-3h74A:
0.0		 3lsfB-3h74A:
20.74
3lsfE-3h74A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngx BIFUNCTIONAL PROTEIN
FOLD

(Thermoplasma
acidophilum) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 PRO A 165
SER A 159
GLY A 163
PRO A 136
ASP A 233
 None
 1.26A 3lsfB-3ngxA:
0.6
3lsfE-3ngxA:
0.0		 3lsfB-3ngxA:
23.13
3lsfE-3ngxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 PRO A 173
SER A 167
GLY A 171
PRO A 142
ASP A 228
 None
NAP  A1001 (-4.5A)
None
None
None
 1.27A 3lsfB-4b4uA:
undetectable
3lsfE-4b4uA:
1.2		 3lsfB-4b4uA:
20.97
3lsfE-4b4uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 PRO A 129
GLY A 127
PRO A 103
SER A  56
ASP A  98
 FMT  A 501 (-4.8A)
FMT  A 501 (-3.4A)
None
None
None
 1.48A 3lsfB-4kv7A:
2.3
3lsfE-4kv7A:
4.0		 3lsfB-4kv7A:
21.58
3lsfE-4kv7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 PRO A1019
GLY A1017
SER A1071
LEU A1145
LYS A1147
 None
 1.32A 3lsfB-4xqkA:
undetectable
3lsfE-4xqkA:
undetectable		 3lsfB-4xqkA:
9.97
3lsfE-4xqkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymr PROTEIN SNX21

(Mus musculus) 		no annotation 5 PRO A 310
SER A 267
GLY A 268
LEU A 362
ASP A 363
 None
 1.17A 3lsfB-4ymrA:
undetectable
3lsfE-4ymrA:
undetectable		 3lsfB-4ymrA:
22.92
3lsfE-4ymrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN

(Gallus gallus) 		PF03828
(PAP_assoc) 		5 SER A 227
GLY A 225
PRO A 223
SER A 321
LEU A 320
 None
AGS  A1529 (-3.6A)
None
None
None
 1.30A 3lsfB-5a30A:
undetectable
3lsfE-5a30A:
undetectable		 3lsfB-5a30A:
22.16
3lsfE-5a30A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 SER A 345
GLY A 541
MET A 397
SER A 398
SER A 525
 35P  A 702 (-1.3A)
35P  A 702 (-3.5A)
None
35P  A 702 (-2.9A)
None
 1.35A 3lsfB-5cxwA:
undetectable
3lsfE-5cxwA:
undetectable		 3lsfB-5cxwA:
20.90
3lsfE-5cxwA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		7 PRO A 494
MET A 496
SER A 497
SER A 754
LEU A 759
ASP A 760
LYS A 763
 None
 0.54A 3lsfB-5l1bA:
22.4
3lsfE-5l1bA:
22.3		 3lsfB-5l1bA:
70.44
3lsfE-5l1bA:
70.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		6 PRO A 494
MET A 496
SER A 497
SER A 754
LEU A 759
ASP A 760
 None
 0.73A 3lsfB-5welA:
32.7
3lsfE-5welA:
32.5		 3lsfB-5welA:
66.93
3lsfE-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		6 PRO A 494
MET A 496
SER A 497
SER A 754
LEU A 759
LYS A 763
 None
 0.79A 3lsfB-5welA:
32.7
3lsfE-5welA:
32.5		 3lsfB-5welA:
66.93
3lsfE-5welA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PRO A 494
MET A 496
SER A 497
LEU A 759
ASP A 760
 CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 (-3.8A)
 0.77A 3lsfB-5weoA:
25.2
3lsfE-5weoA:
25.1		 3lsfB-5weoA:
66.93
3lsfE-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PRO A 494
MET A 496
SER A 497
LEU A 759
LYS A 763
 CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 (-2.9A)
 0.97A 3lsfB-5weoA:
25.2
3lsfE-5weoA:
25.1		 3lsfB-5weoA:
66.93
3lsfE-5weoA:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PRO A 494
MET A 496
SER A 754
LEU A 759
LYS A 763
 CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 ( 4.1A)
None
CYZ  A1302 (-2.9A)
 1.03A 3lsfB-5weoA:
25.2
3lsfE-5weoA:
25.1		 3lsfB-5weoA:
66.93
3lsfE-5weoA:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 PRO A 177
SER A 171
GLY A 175
PRO A 146
ASP A 246
 None
None
None
None
GOL  A 303 ( 4.8A)
 1.31A 3lsfB-6apeA:
undetectable
3lsfE-6apeA:
undetectable		 3lsfB-6apeA:
22.96
3lsfE-6apeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 5 PRO A 172
SER A 166
GLY A 170
PRO A 141
ASP A 227
 None
IOD  A 303 ( 4.8A)
None
None
None
 1.26A 3lsfB-6de8A:
undetectable
3lsfE-6de8A:
undetectable		 3lsfB-6de8A:
undetectable
3lsfE-6de8A:
undetectable