SIMILAR PATTERNS OF AMINO ACIDS FOR 3LSF_B_PZIB802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
3 SER P 150
ASP P  29
ASN P 282
DDZ  P  69 ( 4.9A)
MG  P 603 (-3.1A)
MG  P 603 (-2.9A)
0.97A 3lsfB-1e33P:
0.0
3lsfE-1e33P:
0.2
3lsfB-1e33P:
18.93
3lsfE-1e33P:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE


(Sus scrofa)
PF00151
(Lipase)
PF01477
(PLAT)
3 SER A 334
ASP A 273
ASN A  93
None
0.98A 3lsfB-1ethA:
0.0
3lsfE-1ethA:
undetectable
3lsfB-1ethA:
18.72
3lsfE-1ethA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jye LACTOSE OPERON
REPRESSOR


(Escherichia
coli)
PF13377
(Peripla_BP_3)
3 SER A 191
ASP A 149
ASN A 125
None
0.92A 3lsfB-1jyeA:
2.4
3lsfE-1jyeA:
3.1
3lsfB-1jyeA:
22.56
3lsfE-1jyeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens)
PF00151
(Lipase)
PF01477
(PLAT)
3 SER B 333
ASP B 272
ASN B  92
BOG  B 452 (-3.5A)
None
None
0.99A 3lsfB-1lpbB:
0.0
3lsfE-1lpbB:
0.0
3lsfB-1lpbB:
18.93
3lsfE-1lpbB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)


(Caenorhabditis
elegans)
PF01633
(Choline_kinase)
3 SER A  86
ASP A 255
ASN A 316
None
0.83A 3lsfB-1nw1A:
0.0
3lsfE-1nw1A:
undetectable
3lsfB-1nw1A:
19.36
3lsfE-1nw1A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Thermotoga
maritima)
PF01979
(Amidohydro_1)
3 SER A 291
ASP A 229
ASN A 301
None
0.92A 3lsfB-1o12A:
0.0
3lsfE-1o12A:
undetectable
3lsfB-1o12A:
22.79
3lsfE-1o12A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album)
PF00082
(Peptidase_S8)
3 SER E 197
ASP E 165
ASN E 168
None
0.86A 3lsfB-1pekE:
0.4
3lsfE-1pekE:
undetectable
3lsfB-1pekE:
21.14
3lsfE-1pekE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1


(Saccharomyces
cerevisiae)
PF00400
(WD40)
3 SER A 336
ASP A 318
ASN A 299
None
0.98A 3lsfB-1pguA:
undetectable
3lsfE-1pguA:
undetectable
3lsfB-1pguA:
18.20
3lsfE-1pguA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE


(Geobacillus
stearothermophilus)
PF06964
(Alpha-L-AF_C)
3 SER A 399
ASP A 253
ASN A 249
None
1.00A 3lsfB-1pz3A:
undetectable
3lsfE-1pz3A:
undetectable
3lsfB-1pz3A:
18.32
3lsfE-1pz3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td0 HEAD DECORATION
PROTEIN


(Escherichia
virus Lambda)
PF02924
(HDPD)
3 SER A 109
ASP A  19
ASN A  18
None
1.01A 3lsfB-1td0A:
undetectable
3lsfE-1td0A:
undetectable
3lsfB-1td0A:
20.48
3lsfE-1td0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli)
PF13377
(Peripla_BP_3)
3 SER A 191
ASP A 149
ASN A 125
IPT  A 998 ( 4.6A)
IPT  A 998 (-3.2A)
IPT  A 998 ( 4.7A)
0.91A 3lsfB-1tlfA:
undetectable
3lsfE-1tlfA:
3.5
3lsfB-1tlfA:
23.65
3lsfE-1tlfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toc ORNITHODORIN

(Ornithodoros
moubata)
no annotation 3 SER R  37
ASP R  16
ASN R  14
None
0.58A 3lsfB-1tocR:
undetectable
3lsfE-1tocR:
undetectable
3lsfB-1tocR:
16.06
3lsfE-1tocR:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE


(Escherichia
coli)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
3 SER A 325
ASP A 317
ASN A 316
SO4  A 964 ( 4.9A)
None
None
0.88A 3lsfB-1uagA:
undetectable
3lsfE-1uagA:
undetectable
3lsfB-1uagA:
21.36
3lsfE-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
3 SER A 183
ASP A 238
ASN A 239
None
None
FAD  A1660 (-4.4A)
0.99A 3lsfB-1w07A:
undetectable
3lsfE-1w07A:
undetectable
3lsfB-1w07A:
18.51
3lsfE-1w07A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1


(Rattus
norvegicus)
PF01661
(Macro)
3 SER A 156
ASP A 191
ASN A 193
None
0.69A 3lsfB-1yd9A:
undetectable
3lsfE-1yd9A:
undetectable
3lsfB-1yd9A:
20.52
3lsfE-1yd9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima)
PF02065
(Melibiase)
3 SER A 492
ASP A 494
ASN A 516
None
1.03A 3lsfB-1zy9A:
undetectable
3lsfE-1zy9A:
undetectable
3lsfB-1zy9A:
20.22
3lsfE-1zy9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE


(Vespula
vulgaris)
PF01630
(Glyco_hydro_56)
3 SER A  38
ASP A  45
ASN A  97
None
0.99A 3lsfB-2atmA:
undetectable
3lsfE-2atmA:
undetectable
3lsfB-2atmA:
21.08
3lsfE-2atmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE


(Streptococcus
pyogenes)
PF09028
(Mac-1)
3 SER A 287
ASP A  81
ASN A 101
None
1.00A 3lsfB-2au1A:
undetectable
3lsfE-2au1A:
undetectable
3lsfB-2au1A:
21.26
3lsfE-2au1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
3 SER A 154
ASP A 134
ASN A 150
None
0.91A 3lsfB-2c4kA:
undetectable
3lsfE-2c4kA:
undetectable
3lsfB-2c4kA:
21.98
3lsfE-2c4kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00180
(Iso_dh)
3 SER A 154
ASP A 442
ASN A 399
None
0.97A 3lsfB-2d1cA:
undetectable
3lsfE-2d1cA:
undetectable
3lsfB-2d1cA:
19.68
3lsfE-2d1cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
3 SER A 184
ASP A 236
ASN A 237
None
None
FAD  A 699 (-4.0A)
0.99A 3lsfB-2ddhA:
undetectable
3lsfE-2ddhA:
undetectable
3lsfB-2ddhA:
17.64
3lsfE-2ddhA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN


(Daboia
siamensis)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
3 SER A  22
ASP A  66
ASN A  69
None
None
NAG  A 900 ( 2.0A)
0.94A 3lsfB-2e3xA:
undetectable
3lsfE-2e3xA:
undetectable
3lsfB-2e3xA:
18.79
3lsfE-2e3xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4


(Escherichia
coli)
PF02113
(Peptidase_S13)
3 SER A 388
ASP A 381
ASN A 382
None
0.96A 3lsfB-2exaA:
undetectable
3lsfE-2exaA:
undetectable
3lsfB-2exaA:
20.48
3lsfE-2exaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
3 SER A 773
ASP A 666
ASN A 594
None
0.82A 3lsfB-2f3oA:
undetectable
3lsfE-2f3oA:
undetectable
3lsfB-2f3oA:
17.65
3lsfE-2f3oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsb RAS
GTPASE-ACTIVATING
PROTEIN 1


(Homo sapiens)
PF00017
(SH2)
3 SER A  24
ASP A  47
ASN A  48
None
0.98A 3lsfB-2gsbA:
undetectable
3lsfE-2gsbA:
undetectable
3lsfB-2gsbA:
18.52
3lsfE-2gsbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP


(Vibrio harveyi)
PF13407
(Peripla_BP_4)
3 SER A 207
ASP A 136
ASN A 159
None
None
AI2  A 501 (-3.3A)
1.01A 3lsfB-2hj9A:
3.2
3lsfE-2hj9A:
2.5
3lsfB-2hj9A:
20.11
3lsfE-2hj9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC
GU4 NUCLEIC-BINDING
PROTEIN 1


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF09635
(MetRS-N)
no annotation
3 SER A   4
ASP B  55
ASN B  56
None
0.99A 3lsfB-2hsnA:
undetectable
3lsfE-2hsnA:
undetectable
3lsfB-2hsnA:
20.46
3lsfE-2hsnA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Escherichia
coli)
PF01979
(Amidohydro_1)
3 SER A 309
ASP A 248
ASN A 319
None
0.92A 3lsfB-2p50A:
undetectable
3lsfE-2p50A:
undetectable
3lsfB-2p50A:
21.14
3lsfE-2p50A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae)
PF04097
(Nic96)
3 SER A 421
ASP A 419
ASN A 395
None
0.87A 3lsfB-2rfoA:
undetectable
3lsfE-2rfoA:
undetectable
3lsfB-2rfoA:
17.21
3lsfE-2rfoA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum)
PF00245
(Alk_phosphatase)
3 SER A 375
ASP A 261
ASN A 268
None
0.79A 3lsfB-2x98A:
undetectable
3lsfE-2x98A:
undetectable
3lsfB-2x98A:
19.03
3lsfE-2x98A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca)
PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372)
3 SER A 327
ASP A 242
ASN A 240
None
SO4  A2078 (-4.4A)
None
1.00A 3lsfB-2yocA:
undetectable
3lsfE-2yocA:
undetectable
3lsfB-2yocA:
13.07
3lsfE-2yocA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckm YRAM (HI1655)

(Haemophilus
influenzae)
PF04348
(LppC)
3 SER A 549
ASP A 559
ASN A 371
None
0.98A 3lsfB-3ckmA:
undetectable
3lsfE-3ckmA:
undetectable
3lsfB-3ckmA:
19.94
3lsfE-3ckmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR


(Lactobacillus
plantarum)
PF13377
(Peripla_BP_3)
3 SER A 288
ASP A 247
ASN A  74
None
0.99A 3lsfB-3clkA:
undetectable
3lsfE-3clkA:
2.7
3lsfB-3clkA:
22.87
3lsfE-3clkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6i MONOTHIOL
GLUTAREDOXIN-3


(Saccharomyces
cerevisiae)
PF00085
(Thioredoxin)
3 SER A  67
ASP A  97
ASN A  42
None
1.03A 3lsfB-3d6iA:
undetectable
3lsfE-3d6iA:
undetectable
3lsfB-3d6iA:
17.06
3lsfE-3d6iA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus)
PF07859
(Abhydrolase_3)
3 SER A 188
ASP A 184
ASN A 230
None
0.83A 3lsfB-3d7rA:
undetectable
3lsfE-3d7rA:
undetectable
3lsfB-3d7rA:
18.60
3lsfE-3d7rA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
PF00912
(Transgly)
3 SER A 297
ASP A 348
ASN A 349
None
1.02A 3lsfB-3dwkA:
undetectable
3lsfE-3dwkA:
undetectable
3lsfB-3dwkA:
17.16
3lsfE-3dwkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Vibrio cholerae)
PF01979
(Amidohydro_1)
3 SER A 306
ASP A 245
ASN A 316
None
0.86A 3lsfB-3egjA:
undetectable
3lsfE-3egjA:
undetectable
3lsfB-3egjA:
23.51
3lsfE-3egjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 SER A  57
ASP A 121
ASN A 124
None
None
NAG  A 521 (-2.9A)
0.91A 3lsfB-3fw8A:
undetectable
3lsfE-3fw8A:
undetectable
3lsfB-3fw8A:
21.41
3lsfE-3fw8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus)
PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
3 SER A  86
ASP A 487
ASN A 484
None
0.95A 3lsfB-3h7lA:
undetectable
3lsfE-3h7lA:
undetectable
3lsfB-3h7lA:
16.84
3lsfE-3h7lA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA


(Moorella
thermoacetica;
Moorella
thermoacetica)
PF03063
(Prismane)
PF03598
(CdhC)
3 SER M  34
ASP A 226
ASN A 225
None
0.98A 3lsfB-3i04M:
undetectable
3lsfE-3i04M:
undetectable
3lsfB-3i04M:
18.31
3lsfE-3i04M:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A


(Salmonella
enterica)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
3 SER A 115
ASP A 113
ASN A 188
None
0.99A 3lsfB-3i12A:
undetectable
3lsfE-3i12A:
undetectable
3lsfB-3i12A:
21.99
3lsfE-3i12A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A


(Salmonella
enterica)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
3 SER A 326
ASP A 263
ASN A 264
None
0.91A 3lsfB-3i12A:
undetectable
3lsfE-3i12A:
undetectable
3lsfB-3i12A:
21.99
3lsfE-3i12A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21


(Homo sapiens)
PF00443
(UCH)
3 SER A 494
ASP A 352
ASN A 356
None
0.77A 3lsfB-3i3tA:
undetectable
3lsfE-3i3tA:
undetectable
3lsfB-3i3tA:
21.01
3lsfE-3i3tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4


(Thermus
thermophilus)
PF00346
(Complex1_49kDa)
3 SER 4 128
ASP 4 401
ASN 4 377
None
0.94A 3lsfB-3i9v4:
undetectable
3lsfE-3i9v4:
undetectable
3lsfB-3i9v4:
20.62
3lsfE-3i9v4:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus)
PF00901
(Orbi_VP5)
3 SER D 305
ASP D 472
ASN D 476
None
0.39A 3lsfB-3j9eD:
undetectable
3lsfE-3j9eD:
undetectable
3lsfB-3j9eD:
19.08
3lsfE-3j9eD:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF14


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF01423
(LSM)
3 SER A 509
ASP A  81
ASN e  87
None
None
G  C  75 ( 4.7A)
0.94A 3lsfB-3jb9A:
undetectable
3lsfE-3jb9A:
undetectable
3lsfB-3jb9A:
7.59
3lsfE-3jb9A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN


(Homo sapiens)
PF00516
(GP120)
3 SER A 365
ASP A 457
ASN A 462
None
0.89A 3lsfB-3jwoA:
undetectable
3lsfE-3jwoA:
undetectable
3lsfB-3jwoA:
20.38
3lsfE-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
3 SER A 210
ASP A 102
ASN A 105
None
0.84A 3lsfB-3lhxA:
undetectable
3lsfE-3lhxA:
undetectable
3lsfB-3lhxA:
22.33
3lsfE-3lhxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz1 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Sinorhizobium
meliloti)
PF03466
(LysR_substrate)
3 SER A  94
ASP A 123
ASN A 218
None
0.82A 3lsfB-3mz1A:
7.9
3lsfE-3mz1A:
8.0
3lsfB-3mz1A:
21.54
3lsfE-3mz1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE


(Methylobacillus
flagellatus)
PF14403
(CP_ATPgrasp_2)
3 SER A 349
ASP A 321
ASN A 123
None
0.97A 3lsfB-3n6xA:
undetectable
3lsfE-3n6xA:
undetectable
3lsfB-3n6xA:
19.67
3lsfE-3n6xA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE


(Clostridioides
difficile)
PF06050
(HGD-D)
3 SER B  73
ASP B 352
ASN B 358
None
1.02A 3lsfB-3o3mB:
undetectable
3lsfE-3o3mB:
undetectable
3lsfB-3o3mB:
19.90
3lsfE-3o3mB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4


(Homo sapiens)
PF13561
(adh_short_C2)
3 SER A 218
ASP A  42
ASN A  68
NAP  A 601 ( 4.4A)
NAP  A 601 (-3.9A)
NAP  A 601 (-3.8A)
1.02A 3lsfB-3o4rA:
undetectable
3lsfE-3o4rA:
undetectable
3lsfB-3o4rA:
22.34
3lsfE-3o4rA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN


(Enterococcus
faecalis)
PF00496
(SBP_bac_5)
3 SER A 492
ASP A 466
ASN A 472
None
0.83A 3lsfB-3o6pA:
undetectable
3lsfE-3o6pA:
1.4
3lsfB-3o6pA:
21.37
3lsfE-3o6pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN


(Homo sapiens)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
3 SER B 232
ASP B 491
ASN B 515
None
0.87A 3lsfB-3ojyB:
undetectable
3lsfE-3ojyB:
undetectable
3lsfB-3ojyB:
19.72
3lsfE-3ojyB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE


(Vibrio
parahaemolyticus)
PF02502
(LacAB_rpiB)
PF12408
(DUF3666)
3 SER A 186
ASP A  43
ASN A  15
None
0.98A 3lsfB-3onoA:
undetectable
3lsfE-3onoA:
undetectable
3lsfB-3onoA:
22.27
3lsfE-3onoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyo HEMOPEXIN FOLD
PROTEIN CP4


(Vigna
unguiculata)
PF00045
(Hemopexin)
3 SER A 119
ASP A  65
ASN A   7
None
None
CA  A 228 (-3.5A)
0.99A 3lsfB-3oyoA:
undetectable
3lsfE-3oyoA:
undetectable
3lsfB-3oyoA:
23.96
3lsfE-3oyoA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE


(Bordetella
bronchiseptica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 SER A  53
ASP A 308
ASN A 335
None
1.02A 3lsfB-3ozyA:
undetectable
3lsfE-3ozyA:
undetectable
3lsfB-3ozyA:
21.35
3lsfE-3ozyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 SER A 313
ASP A 141
ASN A 195
None
0.96A 3lsfB-3p5pA:
undetectable
3lsfE-3p5pA:
undetectable
3lsfB-3p5pA:
15.02
3lsfE-3p5pA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Legionella
pneumophila)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 SER A 164
ASP A  98
ASN A  31
GOL  A 523 (-4.2A)
None
None
1.02A 3lsfB-3pfeA:
undetectable
3lsfE-3pfeA:
undetectable
3lsfB-3pfeA:
20.77
3lsfE-3pfeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY


(Francisella
philomiragia)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 SER A 137
ASP A 321
ASN A 267
None
0.98A 3lsfB-3r11A:
undetectable
3lsfE-3r11A:
undetectable
3lsfB-3r11A:
20.68
3lsfE-3r11A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE
CASPASE


(Drosophila
melanogaster;
Drosophila
melanogaster)
PF00656
(Peptidase_C14)
PF00656
(Peptidase_C14)
3 SER B 192
ASP A  45
ASN A  27
None
1.03A 3lsfB-3sipB:
undetectable
3lsfE-3sipB:
undetectable
3lsfB-3sipB:
16.15
3lsfE-3sipB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3


(Homo sapiens)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III)
3 SER B 403
ASP B 398
ASN B 376
None
1.01A 3lsfB-3thwB:
undetectable
3lsfE-3thwB:
undetectable
3lsfB-3thwB:
14.68
3lsfE-3thwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyg ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
3 SER A 154
ASP A  27
ASN A  83
None
1.00A 3lsfB-3tygA:
undetectable
3lsfE-3tygA:
undetectable
3lsfB-3tygA:
20.08
3lsfE-3tygA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN


(Thermus
thermophilus)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
3 SER D 156
ASP D 259
ASN D 262
None
0.67A 3lsfB-3w3aD:
undetectable
3lsfE-3w3aD:
undetectable
3lsfB-3w3aD:
20.52
3lsfE-3w3aD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 3 SER A 224
ASP A 192
ASN A 196
None
0.85A 3lsfB-4bb9A:
undetectable
3lsfE-4bb9A:
undetectable
3lsfB-4bb9A:
17.34
3lsfE-4bb9A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL38

(Sus scrofa)
no annotation 3 SER b 263
ASP b 222
ASN b 220
None
0.82A 3lsfB-4ce4b:
undetectable
3lsfE-4ce4b:
undetectable
3lsfB-4ce4b:
18.05
3lsfE-4ce4b:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE


(Pseudomonas
aeruginosa)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 SER A 239
ASP A 230
ASN A 231
None
0.99A 3lsfB-4cw4A:
undetectable
3lsfE-4cw4A:
undetectable
3lsfB-4cw4A:
17.69
3lsfE-4cw4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN


(Helicobacter
pylori)
no annotation 3 SER A 689
ASP A 787
ASN A 791
None
0.79A 3lsfB-4dvzA:
undetectable
3lsfE-4dvzA:
undetectable
3lsfB-4dvzA:
20.25
3lsfE-4dvzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
3 SER A 841
ASP A 806
ASN A 807
None
0.81A 3lsfB-4fddA:
undetectable
3lsfE-4fddA:
undetectable
3lsfB-4fddA:
14.22
3lsfE-4fddA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 SER A  17
ASP A 144
ASN A 142
None
0.98A 3lsfB-4h19A:
undetectable
3lsfE-4h19A:
undetectable
3lsfB-4h19A:
23.06
3lsfE-4h19A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz9 PUTATIVE CYTOPLASMIC
PROTEIN


(Ralstonia
pickettii)
no annotation 3 SER A  88
ASP A  86
ASN A   9
None
1.01A 3lsfB-4hz9A:
undetectable
3lsfE-4hz9A:
undetectable
3lsfB-4hz9A:
17.96
3lsfE-4hz9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN


(Adineta vaga)
PF00497
(SBP_bac_3)
3 SER A  17
ASP A  85
ASN A 105
None
MET  A 301 (-4.7A)
MET  A 301 ( 4.9A)
0.85A 3lsfB-4io6A:
27.5
3lsfE-4io6A:
27.7
3lsfB-4io6A:
28.83
3lsfE-4io6A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN


(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
3 SER A 194
ASP A 204
ASN A 201
None
0.94A 3lsfB-4l37A:
undetectable
3lsfE-4l37A:
undetectable
3lsfB-4l37A:
17.40
3lsfE-4l37A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
3 SER A1142
ASP A1176
ASN A1170
None
0.95A 3lsfB-4pj3A:
undetectable
3lsfE-4pj3A:
undetectable
3lsfB-4pj3A:
10.71
3lsfE-4pj3A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus)
no annotation 3 SER A  44
ASP A  72
ASN A  71
None
0.99A 3lsfB-4qanA:
undetectable
3lsfE-4qanA:
undetectable
3lsfB-4qanA:
22.38
3lsfE-4qanA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Escherichia
coli)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
3 SER A 149
ASP A 129
ASN A 145
None
1.01A 3lsfB-4s2uA:
undetectable
3lsfE-4s2uA:
undetectable
3lsfB-4s2uA:
23.51
3lsfE-4s2uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum)
PF00704
(Glyco_hydro_18)
3 SER A 331
ASP A 382
ASN A  21
None
0.70A 3lsfB-4tx8A:
undetectable
3lsfE-4tx8A:
undetectable
3lsfB-4tx8A:
18.84
3lsfE-4tx8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7


(Homo sapiens)
PF03133
(TTL)
3 SER A 273
ASP A 223
ASN A 453
None
0.96A 3lsfB-4ylrA:
undetectable
3lsfE-4ylrA:
undetectable
3lsfB-4ylrA:
20.78
3lsfE-4ylrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqu CDII TOXIN

(Salmonella
enterica)
PF07262
(CdiI)
3 SER B 119
ASP B 121
ASN B  30
None
0.92A 3lsfB-4zquB:
undetectable
3lsfE-4zquB:
undetectable
3lsfB-4zquB:
21.97
3lsfE-4zquB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7x HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
3 SER A 365
ASP A 457
ASN A 280
None
0.95A 3lsfB-5a7xA:
undetectable
3lsfE-5a7xA:
undetectable
3lsfB-5a7xA:
22.26
3lsfE-5a7xA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c78 ATP-DRIVEN FLIPPASE
PGLK


(Campylobacter
jejuni)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 SER A 389
ASP A 509
ASN A 431
None
0.84A 3lsfB-5c78A:
undetectable
3lsfE-5c78A:
undetectable
3lsfB-5c78A:
18.95
3lsfE-5c78A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR


(Acinetobacter
baumannii)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 SER A 462
ASP A 513
ASN A 558
None
0.99A 3lsfB-5fp1A:
undetectable
3lsfE-5fp1A:
undetectable
3lsfB-5fp1A:
18.26
3lsfE-5fp1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM


(Salmonella
enterica)
PF00884
(Sulfatase)
PF11893
(DUF3413)
3 SER A 351
ASP A 303
ASN A 304
None
1.02A 3lsfB-5i5dA:
undetectable
3lsfE-5i5dA:
undetectable
3lsfB-5i5dA:
16.70
3lsfE-5i5dA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibv CAPSID POLYPROTEIN
VP90


(Mamastrovirus 1)
PF03115
(Astro_capsid_N)
3 SER A 310
ASP A 321
ASN A 408
None
0.68A 3lsfB-5ibvA:
undetectable
3lsfE-5ibvA:
undetectable
3lsfB-5ibvA:
21.36
3lsfE-5ibvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD


(Pseudomonas
aeruginosa)
PF04453
(OstA_C)
3 SER A 380
ASP A 480
ASN A 478
None
0.85A 3lsfB-5ivaA:
undetectable
3lsfE-5ivaA:
undetectable
3lsfB-5ivaA:
19.04
3lsfE-5ivaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN


(Homo sapiens)
PF00567
(TUDOR)
3 SER A 313
ASP A 393
ASN A 394
None
CAC  A 501 (-3.6A)
None
0.97A 3lsfB-5j39A:
undetectable
3lsfE-5j39A:
undetectable
3lsfB-5j39A:
23.35
3lsfE-5j39A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N)
3 SER A 354
ASP A 435
ASN A 436
None
0.84A 3lsfB-5jmdA:
undetectable
3lsfE-5jmdA:
undetectable
3lsfB-5jmdA:
16.85
3lsfE-5jmdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6


(Ruminiclostridium
thermocellum)
PF00150
(Cellulase)
PF03422
(CBM_6)
3 SER A 426
ASP A 392
ASN A 386
None
CA  A 604 ( 2.4A)
None
1.03A 3lsfB-5la0A:
undetectable
3lsfE-5la0A:
undetectable
3lsfB-5la0A:
20.82
3lsfE-5la0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812)
no annotation 3 SER A  78
ASP A 401
ASN A 406
None
0.99A 3lsfB-5li4A:
undetectable
3lsfE-5li4A:
undetectable
3lsfB-5li4A:
20.04
3lsfE-5li4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


(Escherichia
coli)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
3 SER A 557
ASP A 562
ASN A 681
None
0.97A 3lsfB-5ljoA:
undetectable
3lsfE-5ljoA:
undetectable
3lsfB-5ljoA:
15.79
3lsfE-5ljoA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkn NEURAL CELL ADHESION
MOLECULE 1


(Homo sapiens)
PF00041
(fn3)
3 SER A 643
ASP A 664
ASN A 666
None
0.97A 3lsfB-5lknA:
undetectable
3lsfE-5lknA:
undetectable
3lsfB-5lknA:
15.12
3lsfE-5lknA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE


(Thermocrispum
municipale)
PF07992
(Pyr_redox_2)
3 SER A 188
ASP A  59
ASN A 277
NAP  A 602 (-4.1A)
NAP  A 602 ( 2.9A)
None
0.95A 3lsfB-5m10A:
undetectable
3lsfE-5m10A:
undetectable
3lsfB-5m10A:
20.15
3lsfE-5m10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum)
PF00400
(WD40)
3 SER A  34
ASP A  22
ASN A 544
None
0.82A 3lsfB-5tqrA:
undetectable
3lsfE-5tqrA:
undetectable
3lsfB-5tqrA:
19.34
3lsfE-5tqrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47


(Homo sapiens;
Homo sapiens;
Human
alphaherpesvirus
1)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF05363
(Herpes_US12)
3 SER A 412
ASP X   9
ASN B 269
None
0.92A 3lsfB-5u1dA:
undetectable
3lsfE-5u1dA:
undetectable
3lsfB-5u1dA:
16.58
3lsfE-5u1dA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10)
no annotation 3 SER A  61
ASP A  73
ASN A  75
None
0.94A 3lsfB-5uytA:
undetectable
3lsfE-5uytA:
undetectable
3lsfB-5uytA:
18.93
3lsfE-5uytA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT


(Diaphorobacter
sp. DS2)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
3 SER A 213
ASP A 359
ASN A 363
None
1.01A 3lsfB-5xbpA:
undetectable
3lsfE-5xbpA:
undetectable
3lsfB-5xbpA:
21.48
3lsfE-5xbpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT


(Diaphorobacter
sp. DS2;
Diaphorobacter
sp. DS2)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B)
3 SER A 260
ASP A 262
ASN C  90
None
1.03A 3lsfB-5xbpA:
undetectable
3lsfE-5xbpA:
undetectable
3lsfB-5xbpA:
21.48
3lsfE-5xbpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A


(Danio rerio;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
3 SER A 113
ASP A 298
ASN A  45
None
0.99A 3lsfB-5xszA:
undetectable
3lsfE-5xszA:
undetectable
3lsfB-5xszA:
18.07
3lsfE-5xszA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium)
no annotation 3 SER A 201
ASP A 169
ASN A 172
None
0.94A 3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable
3lsfB-5z6oA:
undetectable
3lsfE-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B


(Flavobacterium
johnsoniae)
no annotation 3 SER B 986
ASP B 959
ASN B 963
None
1.02A 3lsfB-6btmB:
undetectable
3lsfE-6btmB:
undetectable
3lsfB-6btmB:
undetectable
3lsfE-6btmB:
undetectable