SIMILAR PATTERNS OF AMINO ACIDS FOR 3LS4_H_TCIH220_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bb9 AMPHIPHYSIN 2

(Rattus
norvegicus) 		PF14604
(SH3_9) 		5 VAL A  50
VAL A  48
LEU A  42
GLY A  66
GLY A  83
 None
 1.16A 3ls4H-1bb9A:
undetectable		 3ls4H-1bb9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 VAL A 328
VAL A 326
LEU A 324
TYR A 503
GLY A 210
 None
 1.22A 3ls4H-1c2oA:
0.0		 3ls4H-1c2oA:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		5 TRP H  47
TYR H  59
GLY H  99
GLY H 110
TRP H 113
 None
 0.67A 3ls4H-1dqlH:
22.5		 3ls4H-1dqlH:
67.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		5 VAL A 212
LEU A 209
SER A 229
GLY A 196
GLY A  44
 None
 1.07A 3ls4H-1hylA:
undetectable		 3ls4H-1hylA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 TRP B 347
SER B 350
TYR B 359
GLY B 399
TRP B 410
 None
 0.48A 3ls4H-1i8kB:
23.3		 3ls4H-1i8kB:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A  95
VAL A  97
LEU A  99
GLY A 461
GLY A 463
 None
 1.20A 3ls4H-1ig8A:
undetectable		 3ls4H-1ig8A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksh ARF-LIKE PROTEIN 2

(Mus musculus) 		PF00025
(Arf) 		5 LEU A 109
TYR A  76
GLY A  69
VAL A  67
GLY A  23
 None
None
PO4  A 203 (-3.7A)
None
None
 1.29A 3ls4H-1kshA:
undetectable		 3ls4H-1kshA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lo3 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		no annotation 5 TRP Y  47
SER Y  50
TYR Y  61
GLY Y 101
TRP Y 109
 None
AN1  Y 500 ( 4.7A)
AN1  Y 500 ( 4.8A)
AN1  Y 500 ( 3.7A)
None
 0.71A 3ls4H-1lo3Y:
26.9		 3ls4H-1lo3Y:
81.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lo4 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TRP H  47
SER H  50
TYR H  58
GLY H  98
TRP H 108
 None
 0.92A 3ls4H-1lo4H:
28.3		 3ls4H-1lo4H:
79.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 254
VAL A 256
LEU A 209
SER A 247
GLY A 184
 None
 1.26A 3ls4H-1lpfA:
undetectable		 3ls4H-1lpfA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A 200
VAL A 208
LEU A 212
TRP A 211
GLY A 221
 None
 1.29A 3ls4H-1mwoA:
undetectable		 3ls4H-1mwoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 VAL A 460
LEU A 445
GLY A 100
VAL A  96
GLY A 108
 None
 1.12A 3ls4H-1obbA:
undetectable		 3ls4H-1obbA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		5 VAL A  40
LEU A 153
GLY A 329
GLY A 331
TRP A 105
 None
 1.02A 3ls4H-1oduA:
undetectable		 3ls4H-1oduA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 VAL A  27
LEU A  50
GLY A  24
VAL A  19
GLY A  21
 None
None
None
None
GDP  A1318 (-3.3A)
 1.10A 3ls4H-1ofuA:
undetectable		 3ls4H-1ofuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 VAL A 129
VAL A 143
LEU A 144
GLY A 305
GLY A 287
 None
 1.29A 3ls4H-1qe0A:
undetectable		 3ls4H-1qe0A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 VAL A  68
VAL A  37
LEU A  92
VAL A  77
GLY A  80
 None
 1.16A 3ls4H-1rrmA:
undetectable		 3ls4H-1rrmA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux1 CYTIDINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		5 VAL A  26
VAL A  75
LEU A  73
GLY A  27
GLY A  40
 THU  A 138 (-4.2A)
None
None
None
None
 1.30A 3ls4H-1ux1A:
undetectable		 3ls4H-1ux1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3e 50S RIBOSOMAL
PROTEIN L30E

(Thermococcus
celer) 		PF01248
(Ribosomal_L7Ae) 		5 VAL X  85
LEU X  94
TYR X  26
GLY X  14
GLY X  89
 None
 1.16A 3ls4H-1w3eX:
undetectable		 3ls4H-1w3eX:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6b RHO GUANINE EXCHANGE
FACTOR (GEF) 16

(Homo sapiens) 		PF14604
(SH3_9) 		5 VAL A  44
VAL A  42
LEU A  36
GLY A  54
GLY A  63
 None
 1.06A 3ls4H-1x6bA:
undetectable		 3ls4H-1x6bA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Escherichia
coli) 		PF14437
(MafB19-deam) 		5 VAL A  41
VAL A  93
LEU A  91
GLY A  42
GLY A  55
 None
 1.25A 3ls4H-1z3aA:
undetectable		 3ls4H-1z3aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF13603
(tRNA-synt_1_2) 		5 VAL A 261
VAL A 326
GLY A 333
VAL A 245
GLY A 331
 None
 1.16A 3ls4H-2ajhA:
undetectable		 3ls4H-2ajhA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 VAL A1006
VAL A1004
LEU A1000
GLY A1031
GLY A1038
 None
 1.32A 3ls4H-2b5mA:
undetectable		 3ls4H-2b5mA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1

(Homo sapiens) 		PF00400
(WD40) 		5 VAL A 547
LEU A 545
TRP A 557
SER A 555
GLY A 502
 None
 1.22A 3ls4H-2ce9A:
undetectable		 3ls4H-2ce9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		5 VAL A 452
LEU A 440
SER A 453
TYR A 455
GLY A 240
 None
 1.00A 3ls4H-2d1gA:
undetectable		 3ls4H-2d1gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbk CRK-LIKE PROTEIN

(Homo sapiens) 		PF07653
(SH3_2) 		5 VAL A  45
VAL A  43
LEU A  37
GLY A  56
GLY A  63
 None
 0.96A 3ls4H-2dbkA:
undetectable		 3ls4H-2dbkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		5 VAL A 182
VAL A 184
LEU A 186
GLY A 141
GLY A 217
 None
 1.14A 3ls4H-2e8gA:
undetectable		 3ls4H-2e8gA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 367
VAL A 369
TRP A 375
GLY A 346
GLY A 388
 None
 0.98A 3ls4H-2fuvA:
undetectable		 3ls4H-2fuvA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE

(Sulfolobus
solfataricus) 		PF00102
(Y_phosphatase) 		5 VAL A  94
LEU A  35
TYR A 110
GLY A  11
GLY A  99
 None
 1.13A 3ls4H-2i6jA:
undetectable		 3ls4H-2i6jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj1 SORBIN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		5 VAL A  33
VAL A  31
LEU A  25
GLY A  44
GLY A  53
 None
 1.32A 3ls4H-2lj1A:
undetectable		 3ls4H-2lj1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmb PROTEIN (NUMB
PROTEIN)

(Drosophila
melanogaster) 		PF00640
(PID) 		5 VAL A  76
VAL A 123
LEU A 121
GLY A 125
GLY A 127
 None
 1.30A 3ls4H-2nmbA:
undetectable		 3ls4H-2nmbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 VAL 1  23
LEU 1  46
GLY 1  19
VAL 1  15
GLY 1  17
 None
None
None
None
GDP  1 339 (-3.6A)
 1.26A 3ls4H-2r6r1:
undetectable		 3ls4H-2r6r1:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf0 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 10

(Homo sapiens) 		PF14604
(SH3_9) 		5 VAL A  45
VAL A  43
LEU A  37
GLY A  61
GLY A  69
 None
 1.32A 3ls4H-2rf0A:
undetectable		 3ls4H-2rf0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4

(Homo sapiens) 		PF00622
(SPRY) 		5 VAL A 179
LEU A 177
GLY A 116
VAL A 213
TRP A 142
 None
 1.06A 3ls4H-2v24A:
1.9		 3ls4H-2v24A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 VAL A  27
LEU A  50
GLY A  24
VAL A  19
GLY A  21
 None
None
None
None
GDP  A1317 (-3.1A)
 1.14A 3ls4H-2vawA:
undetectable		 3ls4H-2vawA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wst PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 VAL A 131
LEU A 164
GLY A 141
VAL A 160
GLY A 162
 None
 1.20A 3ls4H-2wstA:
undetectable		 3ls4H-2wstA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 293
VAL A 220
LEU A 299
GLY A 224
GLY A 227
 None
 1.21A 3ls4H-2zauA:
undetectable		 3ls4H-2zauA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC) 		5 VAL B 226
LEU B 224
SER B 239
GLY B 168
GLY B 205
 None
 0.99A 3ls4H-3absB:
undetectable		 3ls4H-3absB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC) 		5 VAL B 226
LEU B 224
SER B 239
GLY B 168
GLY B 205
 None
None
B12  B 601 ( 4.6A)
B12  B 601 ( 4.3A)
None
 0.96A 3ls4H-3anyB:
undetectable		 3ls4H-3anyB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL X  95
VAL X  97
LEU X  99
GLY X 460
GLY X 462
 None
 1.09A 3ls4H-3b8aX:
undetectable		 3ls4H-3b8aX:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwl SENSOR PROTEIN

(Haloarcula
marismortui) 		PF08448
(PAS_4) 		5 VAL A 486
VAL A 488
LEU A 490
SER A 505
GLY A 474
 None
None
I3A  A 601 ( 4.7A)
I3A  A 601 ( 4.7A)
None
 0.82A 3ls4H-3bwlA:
undetectable		 3ls4H-3bwlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqo FBP32

(Morone
saxatilis) 		PF00754
(F5_F8_type_C) 		5 VAL A 125
LEU A  57
GLY A  87
VAL A 120
GLY A 122
 None
 1.30A 3ls4H-3cqoA:
2.2		 3ls4H-3cqoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 VAL A  70
LEU A  51
GLY A  67
GLY A  64
TRP A  65
 None
 1.20A 3ls4H-3e73A:
undetectable		 3ls4H-3e73A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 2

(Mus musculus) 		PF00622
(SPRY) 		5 VAL A 169
LEU A 167
GLY A 107
VAL A 203
TRP A 133
 None
 1.16A 3ls4H-3ek9A:
undetectable		 3ls4H-3ek9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		5 VAL A  13
VAL A  15
GLY A  23
VAL A  35
GLY A 119
 None
 1.05A 3ls4H-3faoA:
undetectable		 3ls4H-3faoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 324
VAL A 328
LEU A 332
GLY A 191
VAL A 193
 None
 1.00A 3ls4H-3fmeA:
undetectable		 3ls4H-3fmeA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 VAL A 261
VAL A 293
LEU A 349
GLY A 295
VAL A 345
 None
 1.12A 3ls4H-3h4lA:
undetectable		 3ls4H-3h4lA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		5 VAL A 104
LEU A  62
TYR A  88
GLY A 106
GLY A 110
 None
 1.08A 3ls4H-3ksrA:
undetectable		 3ls4H-3ksrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		5 VAL A 104
VAL A  33
LEU A  62
TYR A  88
GLY A 106
 None
 1.21A 3ls4H-3ksrA:
undetectable		 3ls4H-3ksrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 5 LEU A 261
TYR A 280
GLY A 509
VAL A 485
GLY A 507
 None
 0.96A 3ls4H-3nlcA:
undetectable		 3ls4H-3nlcA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocq PUTATIVE
CYTOSINE/ADENOSINE
DEAMINASE

(Salmonella
enterica) 		PF14437
(MafB19-deam) 		5 VAL A  41
VAL A  93
LEU A  91
GLY A  42
GLY A  55
 None
 1.25A 3ls4H-3ocqA:
undetectable		 3ls4H-3ocqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 VAL A 160
VAL A 180
LEU A 230
TYR A 150
GLY A 158
 None
 1.27A 3ls4H-3otnA:
undetectable		 3ls4H-3otnA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A 200
VAL A 208
LEU A 212
TRP A 211
GLY A 221
 None
None
SUC  A 702 (-3.7A)
None
None
 1.28A 3ls4H-3qgvA:
undetectable		 3ls4H-3qgvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 VAL A   7
VAL A  32
LEU A 119
GLY A   8
GLY A  10
 FAD  A 401 (-4.7A)
None
None
FAD  A 401 (-3.3A)
FAD  A 401 ( 3.7A)
 1.30A 3ls4H-3qj4A:
undetectable		 3ls4H-3qj4A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Shewanella
denitrificans) 		PF00465
(Fe-ADH) 		5 VAL A  95
LEU A 179
GLY A  96
VAL A  41
GLY A  98
 None
 1.17A 3ls4H-3rf7A:
undetectable		 3ls4H-3rf7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 VAL A 450
LEU A 435
GLY A 106
VAL A 102
GLY A 114
 None
 1.02A 3ls4H-3u95A:
undetectable		 3ls4H-3u95A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 VAL A 342
LEU A 344
GLY A 338
GLY A 221
TRP A 442
 None
None
None
IM2  A 800 (-4.0A)
None
 1.12A 3ls4H-3upnA:
undetectable		 3ls4H-3upnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE

(Streptomyces
halstedii) 		PF00561
(Abhydrolase_1) 		5 LEU A  47
SER A  42
TYR A 211
GLY A 112
GLY A 108
 None
 1.33A 3ls4H-3wmrA:
undetectable		 3ls4H-3wmrA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 160
VAL A 162
LEU A 164
GLY A  86
VAL A 138
 None
None
ADP  A1441 ( 4.9A)
None
None
 1.08A 3ls4H-3zl8A:
undetectable		 3ls4H-3zl8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 VAL A 261
VAL A 326
GLY A 333
VAL A 245
GLY A 331
 None
A  B  76 ( 4.0A)
A  B  76 ( 4.1A)
None
A  B  76 ( 4.8A)
 1.25A 3ls4H-4arcA:
undetectable		 3ls4H-4arcA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 VAL A 160
VAL A 163
LEU A 301
SER A 162
GLY A 132
 NAP  A 400 (-3.8A)
None
None
None
None
 1.22A 3ls4H-4b7xA:
undetectable		 3ls4H-4b7xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 VAL A 130
VAL A 110
SER A 127
GLY A 112
GLY A 158
 None
 0.89A 3ls4H-4bkmA:
undetectable		 3ls4H-4bkmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 VAL A 132
VAL A 134
LEU A 148
GLY A 121
GLY A 118
 None
 1.20A 3ls4H-4c7oA:
undetectable		 3ls4H-4c7oA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		5 VAL A 528
VAL A 526
LEU A 446
TYR A 508
GLY A 444
 None
 1.07A 3ls4H-4cvcA:
undetectable		 3ls4H-4cvcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du5 PFKB

(Polaromonas sp.
JS666) 		PF00294
(PfkB) 		5 VAL A 291
LEU A 331
SER A 293
GLY A 308
TRP A 310
 None
 1.31A 3ls4H-4du5A:
undetectable		 3ls4H-4du5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e27 CAPSID PROTEIN

(unidentified) 		no annotation 5 VAL A 159
LEU A  91
GLY A 161
VAL A  87
GLY A  89
 None
 1.00A 3ls4H-4e27A:
undetectable		 3ls4H-4e27A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 VAL A 587
VAL A 589
GLY A 578
VAL A 562
GLY A 564
 None
 1.08A 3ls4H-4e93A:
undetectable		 3ls4H-4e93A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 150
VAL A 148
LEU A 146
GLY A 173
GLY A  20
 None
 1.22A 3ls4H-4ewpA:
undetectable		 3ls4H-4ewpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		5 VAL A 124
VAL A 145
LEU A 142
GLY A 125
TRP A  86
 None
 1.16A 3ls4H-4ezdA:
undetectable		 3ls4H-4ezdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq7 MALEATE CIS-TRANS
ISOMERASE

(Pseudomonas
putida) 		no annotation 5 VAL A 225
LEU A  27
SER A 222
GLY A 245
GLY A 243
 None
 1.19A 3ls4H-4fq7A:
undetectable		 3ls4H-4fq7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
thermoresistibile) 		PF00082
(Peptidase_S8) 		5 VAL A 280
LEU A 278
TYR A 339
VAL A 382
GLY A 379
 None
 1.13A 3ls4H-4hvlA:
undetectable		 3ls4H-4hvlA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 VAL A 280
LEU A 278
TYR A 339
VAL A 382
GLY A 379
 None
 1.19A 3ls4H-4kpgA:
undetectable		 3ls4H-4kpgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 VAL A 280
LEU A 278
TYR A 339
VAL A 382
GLY A 379
 None
 1.14A 3ls4H-4m1zA:
undetectable		 3ls4H-4m1zA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		5 VAL A 275
LEU A 210
SER A 174
GLY A 272
GLY A 168
 None
None
NA  A1004 (-3.1A)
None
None
 1.05A 3ls4H-4mcaA:
undetectable		 3ls4H-4mcaA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		5 TRP B  49
SER B  52
TYR B  61
GLY B 101
TRP B 109
 None
 1.02A 3ls4H-4nikB:
22.7		 3ls4H-4nikB:
45.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Porphyromonas
gingivalis) 		PF01048
(PNP_UDP_1) 		5 VAL A 198
VAL A 200
LEU A 202
GLY A 221
VAL A 219
 CSO  A 146 ( 4.8A)
None
None
None
None
 1.16A 3ls4H-4ns1A:
undetectable		 3ls4H-4ns1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nso EFFECTOR PROTEIN
IMMUNITY PROTEIN

(Vibrio cholerae) 		no annotation 5 VAL A 941
LEU A 857
TYR A 851
GLY B  90
GLY B  93
 None
 1.19A 3ls4H-4nsoA:
undetectable		 3ls4H-4nsoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 VAL A 718
VAL A 720
LEU A 728
SER A 423
GLY A 734
 None
None
None
None
2U4  A 901 ( 4.4A)
 1.19A 3ls4H-4oonA:
undetectable		 3ls4H-4oonA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 VAL A  13
VAL A  54
LEU A  25
SER A  53
GLY A  15
 None
 1.19A 3ls4H-4r1pA:
undetectable		 3ls4H-4r1pA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 VAL A 260
VAL A 277
TYR A 284
GLY A 235
GLY A 207
 None
 1.08A 3ls4H-4wqmA:
undetectable		 3ls4H-4wqmA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		5 VAL A 982
VAL A 984
TYR A 947
GLY A 921
GLY A 905
 None
 0.81A 3ls4H-5bp3A:
undetectable		 3ls4H-5bp3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		5 VAL A 206
LEU A 198
GLY A 191
VAL A 132
GLY A 193
 None
 1.22A 3ls4H-5cbmA:
undetectable		 3ls4H-5cbmA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dlm HEAVY CHAIN OF
MONOCLONAL ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TRP H  47
SER H  50
TYR H  58
GLY H  98
TRP H 105
 None
 0.85A 3ls4H-5dlmH:
28.0		 3ls4H-5dlmH:
86.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 LEU A  78
TYR A 120
GLY A 209
GLY A 211
TRP A 233
 None
 1.26A 3ls4H-5f1qA:
undetectable		 3ls4H-5f1qA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 VAL A1006
VAL A1004
LEU A1000
VAL A1028
GLY A1038
 None
 1.16A 3ls4H-5fqdA:
undetectable		 3ls4H-5fqdA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX

(Escherichia
coli) 		PF04261
(Dyp_perox) 		5 LEU A  96
TRP A  19
TYR A 238
GLY A 287
GLY A 288
 None
 1.12A 3ls4H-5gt2A:
undetectable		 3ls4H-5gt2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE

(Shewanella
oneidensis) 		PF00465
(Fe-ADH) 		5 VAL A  95
LEU A 179
GLY A  96
VAL A  41
GLY A  98
 None
 1.21A 3ls4H-5k8cA:
undetectable		 3ls4H-5k8cA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 VAL A 402
TYR A 410
GLY A 398
VAL A 375
GLY A 571
 None
None
SO4  A 701 (-3.1A)
None
None
 1.33A 3ls4H-5mkkA:
undetectable		 3ls4H-5mkkA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 VAL A 233
VAL A 235
LEU A 415
GLY A 410
VAL A 445
 None
MGD  A2002 ( 4.8A)
None
None
None
 1.26A 3ls4H-5nqdA:
undetectable		 3ls4H-5nqdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A  94
LEU A 297
TYR A  76
GLY A  96
GLY A  98
 None
 1.31A 3ls4H-5tx7A:
undetectable		 3ls4H-5tx7A:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u4r VRC 315 53-1A09 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 LEU A  37
TRP A  47
TYR A  58
GLY A 100
TRP A 103
 None
 1.32A 3ls4H-5u4rA:
26.7		 3ls4H-5u4rA:
65.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vgj VRC38.01 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TRP H  47
SER H  50
TYR H  58
GLY H  95
TRP H 103
 None
None
MAN  G1563 (-3.9A)
MAN  G1606 (-4.1A)
None
 0.69A 3ls4H-5vgjH:
26.4		 3ls4H-5vgjH:
60.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Burkholderia
ambifaria) 		PF12697
(Abhydrolase_6) 		5 VAL A 163
TYR A 175
GLY A 249
GLY A 219
TRP A 218
 None
 1.29A 3ls4H-5w15A:
undetectable		 3ls4H-5w15A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES21

(Toxoplasma
gondii) 		PF01249
(Ribosomal_S21e) 		5 VAL V  58
SER V  64
GLY V  56
VAL V  32
GLY V  30
 None
None
U  21077 ( 4.7A)
None
None
 1.29A 3ls4H-5xxuV:
undetectable		 3ls4H-5xxuV:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 5 VAL A 242
VAL A 226
GLY A 243
VAL A  97
GLY A  95
 None
 1.27A 3ls4H-6cblA:
undetectable		 3ls4H-6cblA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE

(Micromonospora
echinospora) 		no annotation 5 VAL A 243
VAL A 227
GLY A 244
VAL A 100
GLY A  98
 None
 1.26A 3ls4H-6cboA:
undetectable		 3ls4H-6cboA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 5 VAL A 366
SER A 423
TYR A 426
GLY A 363
GLY A 360
 None
 1.27A 3ls4H-6cc4A:
undetectable		 3ls4H-6cc4A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 LEU D 204
SER D 259
TYR D 277
GLY D 139
GLY D 158
 None
 1.21A 3ls4H-6cg0D:
undetectable		 3ls4H-6cg0D:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fej ALL4940 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 VAL A  95
VAL A  93
TYR A  27
GLY A  81
GLY A  18
 None
None
URE  A 202 (-4.7A)
None
None
 1.14A 3ls4H-6fejA:
undetectable		 3ls4H-6fejA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fks -

(-) 		no annotation 5 LEU A  95
TRP A  18
TYR A 237
GLY A 285
GLY A 286
 None
 1.14A 3ls4H-6fksA:
undetectable		 3ls4H-6fksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE

(Thermotoga
maritima) 		no annotation 5 VAL B  17
VAL B  15
LEU B  55
GLY B   5
VAL B  74
 None
 1.24A 3ls4H-6fpeB:
undetectable		 3ls4H-6fpeB:
16.67