SIMILAR PATTERNS OF AMINO ACIDS FOR 3LP9_D_SPMD230

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 GLU A 204
GLU A  84
ASN A  85
 None
 0.89A 3lp9B-1bjwA:
undetectable
3lp9D-1bjwA:
undetectable		 3lp9B-1bjwA:
17.14
3lp9D-1bjwA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		3 GLU Y 112
GLU Y 189
ASN Y 190
 None
 0.91A 3lp9B-1bryY:
0.3
3lp9D-1bryY:
0.1		 3lp9B-1bryY:
22.02
3lp9D-1bryY:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		3 GLU A  66
GLU A  71
ASN A  72
 None
 0.77A 3lp9B-1crlA:
undetectable
3lp9D-1crlA:
undetectable		 3lp9B-1crlA:
17.99
3lp9D-1crlA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		3 GLU A  48
GLU A  71
ASN A 188
 None
 0.81A 3lp9B-1e2tA:
2.0
3lp9D-1e2tA:
2.0		 3lp9B-1e2tA:
19.31
3lp9D-1e2tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		3 GLU A 211
GLU A  72
ASN A  70
 None
 0.86A 3lp9B-1ixpA:
undetectable
3lp9D-1ixpA:
0.0		 3lp9B-1ixpA:
20.87
3lp9D-1ixpA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1joe AUTOINDUCER-2
PRODUCTION PROTEIN

(Haemophilus
influenzae) 		PF02664
(LuxS) 		3 GLU A  46
GLU A 141
ASN A 145
 HG  A 201 ( 4.3A)
None
None
 0.87A 3lp9B-1joeA:
0.6
3lp9D-1joeA:
0.4		 3lp9B-1joeA:
21.12
3lp9D-1joeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE

(Helicobacter
pylori) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 GLU A   6
GLU A 180
ASN A 181
 None
 0.78A 3lp9B-1pu7A:
undetectable
3lp9D-1pu7A:
undetectable		 3lp9B-1pu7A:
24.25
3lp9D-1pu7A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLU A  11
GLU A 135
ASN A 104
 CA  A 906 ( 2.9A)
None
None
 0.67A 3lp9B-1q5aA:
undetectable
3lp9D-1q5aA:
undetectable		 3lp9B-1q5aA:
13.72
3lp9D-1q5aA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 GLU A  37
GLU A  60
ASN A  61
 None
 0.73A 3lp9B-1r8wA:
0.0
3lp9D-1r8wA:
undetectable		 3lp9B-1r8wA:
14.29
3lp9D-1r8wA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlx ALPHA-ACTININ 4

(Homo sapiens) 		PF00435
(Spectrin) 		3 GLU A  69
GLU A 108
ASN A 104
 None
 0.82A 3lp9B-1wlxA:
undetectable
3lp9D-1wlxA:
undetectable		 3lp9B-1wlxA:
20.00
3lp9D-1wlxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		3 GLU A  67
GLU A 300
ASN A 301
 None
 0.86A 3lp9B-1wstA:
0.0
3lp9D-1wstA:
0.0		 3lp9B-1wstA:
18.14
3lp9D-1wstA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyp CALPONIN 1

(Homo sapiens) 		PF00307
(CH) 		3 GLU A  65
GLU A  74
ASN A  75
 None
 0.44A 3lp9B-1wypA:
undetectable
3lp9D-1wypA:
undetectable		 3lp9B-1wypA:
21.59
3lp9D-1wypA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 GLU A 135
GLU A 179
ASN A 164
 None
 0.83A 3lp9B-1xp4A:
undetectable
3lp9D-1xp4A:
undetectable		 3lp9B-1xp4A:
19.79
3lp9D-1xp4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ava ACYL CARRIER PROTEIN
I, CHLOROPLAST

(Spinacia
oleracea) 		PF00550
(PP-binding) 		3 GLU A  15
GLU A  43
ASN A  47
 None
 0.84A 3lp9B-2avaA:
undetectable
3lp9D-2avaA:
undetectable		 3lp9B-2avaA:
15.70
3lp9D-2avaA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		3 GLU A 218
GLU A 191
ASN A 188
 None
 0.74A 3lp9B-2bu2A:
undetectable
3lp9D-2bu2A:
undetectable		 3lp9B-2bu2A:
19.85
3lp9D-2bu2A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czr TBP-INTERACTING
PROTEIN

(Thermococcus
kodakarensis) 		PF15517
(TBPIP_N) 		3 GLU A 211
GLU A 159
ASN A 160
 None
 0.76A 3lp9B-2czrA:
undetectable
3lp9D-2czrA:
undetectable		 3lp9B-2czrA:
21.37
3lp9D-2czrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 GLU A  72
GLU A 113
ASN A 114
 None
 0.91A 3lp9B-2depA:
undetectable
3lp9D-2depA:
undetectable		 3lp9B-2depA:
20.06
3lp9D-2depA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 GLU A  29
GLU A  52
ASN A  53
 None
 0.89A 3lp9B-2f3oA:
undetectable
3lp9D-2f3oA:
undetectable		 3lp9B-2f3oA:
16.46
3lp9D-2f3oA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		3 GLU A 136
GLU A  60
ASN A  61
 None
 0.90A 3lp9B-2gezA:
undetectable
3lp9D-2gezA:
undetectable		 3lp9B-2gezA:
21.37
3lp9D-2gezA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		3 GLU A 672
GLU A 382
ASN A 284
 PLR  A 940 ( 4.5A)
None
None
 0.88A 3lp9B-2gj4A:
undetectable
3lp9D-2gj4A:
undetectable		 3lp9B-2gj4A:
14.09
3lp9D-2gj4A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLU A  29
GLU A  95
ASN A  96
 None
 0.89A 3lp9B-2gp6A:
undetectable
3lp9D-2gp6A:
undetectable		 3lp9B-2gp6A:
17.87
3lp9D-2gp6A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		3 GLU A 178
GLU A 184
ASN A 185
 None
 0.76A 3lp9B-2hlsA:
undetectable
3lp9D-2hlsA:
undetectable		 3lp9B-2hlsA:
19.14
3lp9D-2hlsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		3 GLU A 272
GLU A 313
ASN A 224
 None
K  A 511 (-3.6A)
None
 0.88A 3lp9B-2i2xA:
undetectable
3lp9D-2i2xA:
undetectable		 3lp9B-2i2xA:
19.69
3lp9D-2i2xA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2

(Pseudomonas
aeruginosa) 		PF02127
(Peptidase_M18) 		3 GLU A 211
GLU A  95
ASN A  93
 None
 0.83A 3lp9B-2ijzA:
undetectable
3lp9D-2ijzA:
undetectable		 3lp9B-2ijzA:
20.05
3lp9D-2ijzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		3 GLU A  70
GLU A 158
ASN A 159
 None
 0.76A 3lp9B-2jbwA:
undetectable
3lp9D-2jbwA:
undetectable		 3lp9B-2jbwA:
20.26
3lp9D-2jbwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4o CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1) 		3 GLU A 143
GLU A 186
ASN A 184
 None
 0.80A 3lp9B-2l4oA:
undetectable
3lp9D-2l4oA:
undetectable		 3lp9B-2l4oA:
20.17
3lp9D-2l4oA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj7 DEFENSIN LC-DEF

(Lens culinaris) 		PF00304
(Gamma-thionin) 		3 GLU A  28
GLU A   4
ASN A   5
 None
 0.68A 3lp9B-2lj7A:
undetectable
3lp9D-2lj7A:
undetectable		 3lp9B-2lj7A:
12.62
3lp9D-2lj7A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		3 GLU A  95
GLU A 239
ASN A 240
 None
None
GDP  A3001 (-3.8A)
 0.60A 3lp9B-2nzxA:
undetectable
3lp9D-2nzxA:
undetectable		 3lp9B-2nzxA:
21.14
3lp9D-2nzxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Methanosarcina
mazei) 		PF04406
(TP6A_N) 		3 GLU A 159
GLU A 186
ASN A 184
 None
 0.89A 3lp9B-2q2eA:
undetectable
3lp9D-2q2eA:
undetectable		 3lp9B-2q2eA:
21.10
3lp9D-2q2eA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1

(Homo sapiens) 		PF13238
(AAA_18) 		3 GLU A  44
GLU A  64
ASN A  62
 None
 0.84A 3lp9B-2ql6A:
undetectable
3lp9D-2ql6A:
undetectable		 3lp9B-2ql6A:
20.40
3lp9D-2ql6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU X  40
GLU X   6
ASN X   5
 None
 0.66A 3lp9B-2qvxX:
undetectable
3lp9D-2qvxX:
undetectable		 3lp9B-2qvxX:
16.33
3lp9D-2qvxX:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rvb DNA REPAIR PROTEIN
COMPLEMENTING XP-C
CELLS

(Homo sapiens) 		no annotation 3 GLU A 128
GLU A 120
ASN A 123
 None
 0.89A 3lp9B-2rvbA:
undetectable
3lp9D-2rvbA:
undetectable		 3lp9B-2rvbA:
12.77
3lp9D-2rvbA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		3 GLU A 173
GLU A 141
ASN A 133
 None
 0.85A 3lp9B-2vc6A:
undetectable
3lp9D-2vc6A:
undetectable		 3lp9B-2vc6A:
22.29
3lp9D-2vc6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vns METALLOREDUCTASE
STEAP3

(Homo sapiens) 		PF03807
(F420_oxidored) 		3 GLU A 121
GLU A 127
ASN A 129
 None
 0.65A 3lp9B-2vnsA:
undetectable
3lp9D-2vnsA:
undetectable		 3lp9B-2vnsA:
22.48
3lp9D-2vnsA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 GLU M 527
GLU M 655
ASN M 658
 None
 0.86A 3lp9B-2w4gM:
undetectable
3lp9D-2w4gM:
undetectable		 3lp9B-2w4gM:
14.80
3lp9D-2w4gM:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 GLU A 514
GLU A 434
ASN A 447
 None
 0.86A 3lp9B-2wpgA:
2.7
3lp9D-2wpgA:
1.5		 3lp9B-2wpgA:
17.27
3lp9D-2wpgA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		3 GLU B 544
GLU B 426
ASN B 423
 None
 0.90A 3lp9B-2xa7B:
undetectable
3lp9D-2xa7B:
undetectable		 3lp9B-2xa7B:
17.40
3lp9D-2xa7B:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00957
(Synaptobrevin)
no annotation 		3 GLU A  52
GLU D 630
ASN D 627
 None
 0.89A 3lp9B-3b5nA:
undetectable
3lp9D-3b5nA:
undetectable		 3lp9B-3b5nA:
13.95
3lp9D-3b5nA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		3 GLU A 191
GLU A  73
ASN A 221
 None
 0.67A 3lp9B-3bujA:
undetectable
3lp9D-3bujA:
undetectable		 3lp9B-3bujA:
18.23
3lp9D-3bujA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 GLU A 436
GLU A 349
ASN A 352
 None
 0.90A 3lp9B-3cttA:
2.0
3lp9D-3cttA:
2.0		 3lp9B-3cttA:
14.92
3lp9D-3cttA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		3 GLU A 513
GLU A 433
ASN A 446
 None
 0.89A 3lp9B-3czeA:
1.2
3lp9D-3czeA:
1.2		 3lp9B-3czeA:
15.89
3lp9D-3czeA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d19 CONSERVED
METALLOPROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		3 GLU A 265
GLU A  26
ASN A  25
 None
 0.76A 3lp9B-3d19A:
undetectable
3lp9D-3d19A:
undetectable		 3lp9B-3d19A:
21.23
3lp9D-3d19A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		3 GLU A 305
GLU A 220
ASN A 219
 None
 0.75A 3lp9B-3d5eA:
undetectable
3lp9D-3d5eA:
undetectable		 3lp9B-3d5eA:
22.37
3lp9D-3d5eA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 GLU A 181
GLU A 224
ASN A 225
 None
 0.91A 3lp9B-3fk4A:
undetectable
3lp9D-3fk4A:
undetectable		 3lp9B-3fk4A:
18.20
3lp9D-3fk4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		3 GLU A 363
GLU A 306
ASN A 434
 None
 0.88A 3lp9B-3hoaA:
undetectable
3lp9D-3hoaA:
undetectable		 3lp9B-3hoaA:
17.32
3lp9D-3hoaA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		3 GLU A  94
GLU A 160
ASN A 167
 None
GLU  A 500 (-3.7A)
GLU  A 500 (-3.6A)
 0.91A 3lp9B-3ihaA:
undetectable
3lp9D-3ihaA:
undetectable		 3lp9B-3ihaA:
18.24
3lp9D-3ihaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 3 GLU A  69
GLU A  58
ASN A  64
 None
 0.62A 3lp9B-3ihmA:
undetectable
3lp9D-3ihmA:
undetectable		 3lp9B-3ihmA:
16.71
3lp9D-3ihmA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		3 GLU A 389
GLU A 336
ASN A 339
 None
 0.90A 3lp9B-3k2wA:
undetectable
3lp9D-3k2wA:
undetectable		 3lp9B-3k2wA:
18.14
3lp9D-3k2wA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		3 GLU A 235
GLU A 179
ASN A 205
 None
 0.76A 3lp9B-3lzxA:
undetectable
3lp9D-3lzxA:
undetectable		 3lp9B-3lzxA:
21.04
3lp9D-3lzxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		3 GLU A 617
GLU A 598
ASN A 599
 None
 0.77A 3lp9B-3n9oA:
undetectable
3lp9D-3n9oA:
undetectable		 3lp9B-3n9oA:
17.88
3lp9D-3n9oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		3 GLU A 296
GLU A 349
ASN A 350
 None
 0.75A 3lp9B-3nzqA:
undetectable
3lp9D-3nzqA:
undetectable		 3lp9B-3nzqA:
14.89
3lp9D-3nzqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A 130
GLU A 210
ASN A 246
 None
 0.73A 3lp9B-3owaA:
undetectable
3lp9D-3owaA:
undetectable		 3lp9B-3owaA:
19.16
3lp9D-3owaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		3 GLU A 134
GLU B  29
ASN B  26
 None
 0.75A 3lp9B-3pr2A:
undetectable
3lp9D-3pr2A:
undetectable		 3lp9B-3pr2A:
20.64
3lp9D-3pr2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		3 GLU A 200
GLU A 231
ASN A 192
 None
 0.76A 3lp9B-3rjuA:
undetectable
3lp9D-3rjuA:
undetectable		 3lp9B-3rjuA:
19.67
3lp9D-3rjuA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		3 GLU A 180
GLU A 100
ASN A 101
 None
 0.71A 3lp9B-3s48A:
undetectable
3lp9D-3s48A:
1.2		 3lp9B-3s48A:
26.64
3lp9D-3s48A:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		3 GLU A 288
GLU A 278
ASN A 281
 None
 0.73A 3lp9B-3s9jA:
2.8
3lp9D-3s9jA:
2.8		 3lp9B-3s9jA:
20.86
3lp9D-3s9jA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		3 GLU A 373
GLU A 422
ASN A 484
 None
 0.90A 3lp9B-3smtA:
undetectable
3lp9D-3smtA:
undetectable		 3lp9B-3smtA:
16.83
3lp9D-3smtA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3taw HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Parabacteroides
distasonis) 		PF04041
(Glyco_hydro_130) 		3 GLU A 194
GLU A 141
ASN A 142
 EDO  A 397 (-2.8A)
None
EDO  A 397 (-3.1A)
 0.81A 3lp9B-3tawA:
5.4
3lp9D-3tawA:
5.8		 3lp9B-3tawA:
20.78
3lp9D-3tawA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3taw HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Parabacteroides
distasonis) 		PF04041
(Glyco_hydro_130) 		3 GLU A 194
GLU A 143
ASN A 142
 EDO  A 397 (-2.8A)
None
EDO  A 397 (-3.1A)
 0.86A 3lp9B-3tawA:
5.4
3lp9D-3tawA:
5.8		 3lp9B-3tawA:
20.78
3lp9D-3tawA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)

(Bacillus cereus) 		PF01497
(Peripla_BP_2) 		3 GLU A 109
GLU A  28
ASN A  88
 None
 0.88A 3lp9B-3tnyA:
undetectable
3lp9D-3tnyA:
undetectable		 3lp9B-3tnyA:
23.47
3lp9D-3tnyA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Coxiella
burnetii) 		PF02348
(CTP_transf_3) 		3 GLU A 240
GLU A 136
ASN A 139
 None
 0.87A 3lp9B-3tqdA:
undetectable
3lp9D-3tqdA:
undetectable		 3lp9B-3tqdA:
19.26
3lp9D-3tqdA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vp5 TRANSCRIPTIONAL
REGULATOR

(Lactococcus
lactis) 		PF00440
(TetR_N) 		3 GLU A 158
GLU A 167
ASN A 168
 None
 0.81A 3lp9B-3vp5A:
undetectable
3lp9D-3vp5A:
undetectable		 3lp9B-3vp5A:
21.46
3lp9D-3vp5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 GLU A 538
GLU A 279
ASN A 280
 None
 0.89A 3lp9B-3zusA:
undetectable
3lp9D-3zusA:
undetectable		 3lp9B-3zusA:
14.29
3lp9D-3zusA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 GLU A 758
GLU A 279
ASN A 280
 None
 0.84A 3lp9B-3zusA:
undetectable
3lp9D-3zusA:
undetectable		 3lp9B-3zusA:
14.29
3lp9D-3zusA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		3 GLU A  28
GLU A 316
ASN A 313
 None
 0.86A 3lp9B-4aq4A:
undetectable
3lp9D-4aq4A:
undetectable		 3lp9B-4aq4A:
20.30
3lp9D-4aq4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		3 GLU A 239
GLU A  41
ASN A  44
 None
 0.91A 3lp9B-4hqfA:
undetectable
3lp9D-4hqfA:
undetectable		 3lp9B-4hqfA:
19.64
3lp9D-4hqfA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		3 GLU A 204
GLU A  59
ASN A 208
 None
 0.79A 3lp9B-4i6nA:
undetectable
3lp9D-4i6nA:
undetectable		 3lp9B-4i6nA:
18.70
3lp9D-4i6nA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isc METHYLTRANSFERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF05401
(NodS) 		3 GLU A  27
GLU A 113
ASN A  53
 None
 0.90A 3lp9B-4iscA:
undetectable
3lp9D-4iscA:
undetectable		 3lp9B-4iscA:
16.81
3lp9D-4iscA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		3 GLU A 139
GLU A 190
ASN A 238
 None
 0.81A 3lp9B-4j7hA:
undetectable
3lp9D-4j7hA:
undetectable		 3lp9B-4j7hA:
17.73
3lp9D-4j7hA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		3 GLU A 266
GLU A 192
ASN A 198
 None
 0.79A 3lp9B-4kriA:
undetectable
3lp9D-4kriA:
undetectable		 3lp9B-4kriA:
19.22
3lp9D-4kriA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		3 GLU A 299
GLU A 293
ASN A 292
 None
 0.87A 3lp9B-4mt6A:
2.2
3lp9D-4mt6A:
2.4		 3lp9B-4mt6A:
18.08
3lp9D-4mt6A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		3 GLU A 289
GLU A 337
ASN A 338
 None
 0.79A 3lp9B-4mzdA:
undetectable
3lp9D-4mzdA:
undetectable		 3lp9B-4mzdA:
17.24
3lp9D-4mzdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		3 GLU A 210
GLU A 218
ASN A 219
 None
 0.90A 3lp9B-4oalA:
undetectable
3lp9D-4oalA:
undetectable		 3lp9B-4oalA:
17.55
3lp9D-4oalA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 GLU A 883
GLU A 907
ASN A 908
 None
 0.83A 3lp9B-4q0wA:
undetectable
3lp9D-4q0wA:
undetectable		 3lp9B-4q0wA:
22.99
3lp9D-4q0wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B

(Homo sapiens) 		PF10294
(Methyltransf_16) 		3 GLU A 189
GLU A 209
ASN A 212
 None
 0.90A 3lp9B-4qpnA:
undetectable
3lp9D-4qpnA:
undetectable		 3lp9B-4qpnA:
19.69
3lp9D-4qpnA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		3 GLU A 248
GLU A 295
ASN A 291
 None
 0.89A 3lp9B-4uy6A:
undetectable
3lp9D-4uy6A:
undetectable		 3lp9B-4uy6A:
22.22
3lp9D-4uy6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens) 		PF00443
(UCH) 		3 GLU B 170
GLU B  61
ASN B  62
 None
 0.86A 3lp9B-5cvoB:
undetectable
3lp9D-5cvoB:
undetectable		 3lp9B-5cvoB:
20.39
3lp9D-5cvoB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		3 GLU A 904
GLU A 892
ASN A 895
 None
 0.84A 3lp9B-5d0fA:
1.4
3lp9D-5d0fA:
1.3		 3lp9B-5d0fA:
9.79
3lp9D-5d0fA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		3 GLU A 625
GLU A 657
ASN A 655
 None
 0.83A 3lp9B-5e31A:
2.2
3lp9D-5e31A:
2.3		 3lp9B-5e31A:
18.73
3lp9D-5e31A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 GLU A 554
GLU A 999
ASN A1000
 None
 0.91A 3lp9B-5epgA:
undetectable
3lp9D-5epgA:
undetectable		 3lp9B-5epgA:
10.93
3lp9D-5epgA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		3 GLU A 335
GLU A 447
ASN A 445
 None
 0.92A 3lp9B-5fygA:
undetectable
3lp9D-5fygA:
undetectable		 3lp9B-5fygA:
17.77
3lp9D-5fygA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP41 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		3 GLU B 630
GLU B 621
ASN B 625
 NAG  B6251 (-4.3A)
NAG  B6161 ( 3.6A)
NAG  B6251 (-1.9A)
 0.83A 3lp9B-5fyjB:
undetectable
3lp9D-5fyjB:
undetectable		 3lp9B-5fyjB:
17.30
3lp9D-5fyjB:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		3 GLU A 291
GLU A 213
ASN A 214
 None
 0.89A 3lp9B-5gslA:
undetectable
3lp9D-5gslA:
undetectable		 3lp9B-5gslA:
14.82
3lp9D-5gslA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3g PUTATIVE ACYL-COA
BINDING PROTEIN
(ACBP)

(Oryza sativa) 		PF00887
(ACBP) 		3 GLU A  85
GLU A  24
ASN A  25
 None
 0.75A 3lp9B-5h3gA:
undetectable
3lp9D-5h3gA:
undetectable		 3lp9B-5h3gA:
20.00
3lp9D-5h3gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 GLU A 371
GLU A  52
ASN A 341
 None
 0.86A 3lp9B-5j04A:
undetectable
3lp9D-5j04A:
undetectable		 3lp9B-5j04A:
18.24
3lp9D-5j04A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jff PROBABLE ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FIC
UNCHARACTERIZED
PROTEIN YHFG

(Escherichia
coli) 		PF02661
(Fic)
PF10832
(DUF2559) 		3 GLU B  28
GLU A 168
ASN A 171
 None
 0.68A 3lp9B-5jffB:
undetectable
3lp9D-5jffB:
undetectable		 3lp9B-5jffB:
15.31
3lp9D-5jffB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jla PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		3 GLU A  27
GLU A 222
ASN A 218
 None
 0.79A 3lp9B-5jlaA:
undetectable
3lp9D-5jlaA:
undetectable		 3lp9B-5jlaA:
21.71
3lp9D-5jlaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 GLU A 731
GLU A 629
ASN A 630
 None
 0.54A 3lp9B-5jqkA:
undetectable
3lp9D-5jqkA:
undetectable		 3lp9B-5jqkA:
17.14
3lp9D-5jqkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		3 GLU A 172
GLU A  31
ASN A  70
 None
 0.87A 3lp9B-5kc9A:
undetectable
3lp9D-5kc9A:
undetectable		 3lp9B-5kc9A:
19.65
3lp9D-5kc9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 GLU A 327
GLU A 131
ASN A 264
 None
 0.80A 3lp9B-5ldfA:
undetectable
3lp9D-5ldfA:
undetectable		 3lp9B-5ldfA:
20.54
3lp9D-5ldfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 GLU A 327
GLU A 212
ASN A 264
 None
 0.77A 3lp9B-5ldfA:
undetectable
3lp9D-5ldfA:
undetectable		 3lp9B-5ldfA:
20.54
3lp9D-5ldfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 3 GLU A 145
GLU A   4
ASN A 213
 None
 0.84A 3lp9B-5lf9A:
undetectable
3lp9D-5lf9A:
undetectable		 3lp9B-5lf9A:
21.27
3lp9D-5lf9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 GLU A 220
GLU B 322
ASN B 323
 None
 0.79A 3lp9B-5nd1A:
undetectable
3lp9D-5nd1A:
undetectable		 3lp9B-5nd1A:
14.29
3lp9D-5nd1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 3 GLU A 327
GLU A 355
ASN A 358
 None
 0.88A 3lp9B-5nf2A:
undetectable
3lp9D-5nf2A:
undetectable		 3lp9B-5nf2A:
19.56
3lp9D-5nf2A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obn RNA-BINDING PROTEIN
40

(Homo sapiens) 		no annotation 3 GLU A 512
GLU A 476
ASN A 475
 None
 0.89A 3lp9B-5obnA:
undetectable
3lp9D-5obnA:
undetectable		 3lp9B-5obnA:
14.81
3lp9D-5obnA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		3 GLU A 122
GLU A 205
ASN A 206
 None
 0.91A 3lp9B-5volA:
undetectable
3lp9D-5volA:
undetectable		 3lp9B-5volA:
22.30
3lp9D-5volA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 3 GLU A 273
GLU A 152
ASN A 153
 None
 0.82A 3lp9B-5wmlA:
undetectable
3lp9D-5wmlA:
undetectable		 3lp9B-5wmlA:
undetectable
3lp9D-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 3 GLU A 221
GLU A 195
ASN A 148
 None
 0.89A 3lp9B-5yy8A:
5.9
3lp9D-5yy8A:
4.8		 3lp9B-5yy8A:
17.86
3lp9D-5yy8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu0 TRANSCRIPTION FACTOR
TFIIIB COMPONENT B''

(Saccharomyces
cerevisiae) 		no annotation 3 GLU V 337
GLU V 399
ASN V 400
 None
 0.86A 3lp9B-6eu0V:
undetectable
3lp9D-6eu0V:
undetectable		 3lp9B-6eu0V:
14.54
3lp9D-6eu0V:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 3 GLU A 101
GLU A 115
ASN A 116
 None
 0.74A 3lp9B-6fhsA:
undetectable
3lp9D-6fhsA:
undetectable		 3lp9B-6fhsA:
15.86
3lp9D-6fhsA:
15.86