SIMILAR PATTERNS OF AMINO ACIDS FOR 3LP1_A_NVPA701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A 355
VAL A 290
TYR A 329
GLY A 289
LEU A 307
 None
 1.31A 3lp1A-1crkA:
2.6		 3lp1A-1crkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.24A 3lp1A-1fztA:
undetectable		 3lp1A-1fztA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		5 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
 None
 0.65A 3lp1A-1harA:
27.5		 3lp1A-1harA:
93.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		5 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.32A 3lp1A-1k7yA:
1.1		 3lp1A-1k7yA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
 None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
 1.22A 3lp1A-1mt5A:
0.0		 3lp1A-1mt5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.09A 3lp1A-1oypA:
undetectable		 3lp1A-1oypA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 LEU A 798
VAL A 667
GLY A 733
TRP A 721
LEU A 726
 None
 1.27A 3lp1A-1qb4A:
2.5		 3lp1A-1qb4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		5 ASN A 413
VAL A 416
VAL A 374
TYR A 367
GLY A 373
 None
 1.49A 3lp1A-1qw5A:
0.0		 3lp1A-1qw5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 LEU A 539
VAL A 440
VAL A 432
GLY A 439
LEU A 535
 None
 1.04A 3lp1A-1su7A:
0.0		 3lp1A-1su7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.10A 3lp1A-1udqA:
undetectable		 3lp1A-1udqA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		5 ASN A 173
VAL A 141
TYR A 167
GLY A 142
LEU A 150
 None
 1.43A 3lp1A-1vs1A:
undetectable		 3lp1A-1vs1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 VAL A 503
VAL A 483
TYR A 508
TYR A 542
GLY A 540
 None
 1.47A 3lp1A-1wdtA:
4.2		 3lp1A-1wdtA:
24.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 ASN A 319
VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.98A 3lp1A-1wzaA:
undetectable		 3lp1A-1wzaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xk5 SNURPORTIN-1

(Homo sapiens) 		no annotation 5 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.37A 3lp1A-1xk5A:
undetectable		 3lp1A-1xk5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.41A 3lp1A-1yhuA:
undetectable		 3lp1A-1yhuA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A  60
VAL A  87
GLY A  88
LEU A  12
TYR A  44
 GOL  A1272 (-4.0A)
None
GOL  A1271 (-3.8A)
None
None
 1.17A 3lp1A-1yq9A:
undetectable		 3lp1A-1yq9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmo HALOHYDRIN
DEHALOGENASE

(Arthrobacter
sp. AD2) 		PF13561
(adh_short_C2) 		5 LEU A 165
VAL A 158
VAL A 232
GLY A 233
LEU A 114
 None
 1.45A 3lp1A-1zmoA:
undetectable		 3lp1A-1zmoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 LEU A  27
ASN A  25
VAL A 340
GLY A 341
LEU A   8
 None
 1.46A 3lp1A-2b3xA:
undetectable		 3lp1A-2b3xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 396
VAL A 370
VAL A 368
GLY A 369
LEU A 400
 None
 1.44A 3lp1A-2dsjA:
undetectable		 3lp1A-2dsjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A  20
VAL A 108
VAL A  61
GLY A 110
LEU A  55
 None
 1.38A 3lp1A-2gtrA:
undetectable		 3lp1A-2gtrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.46A 3lp1A-2h8qA:
undetectable		 3lp1A-2h8qA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.32A 3lp1A-2hlwA:
undetectable		 3lp1A-2hlwA:
14.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.75A 3lp1A-2hnzA:
37.9		 3lp1A-2hnzA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 130
VAL A 148
VAL A 230
GLY A 147
TYR A 196
 None
 1.28A 3lp1A-2ix4A:
undetectable		 3lp1A-2ix4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		5 ASN A 193
VAL A 196
TYR A  58
TYR A  61
GLY A 195
 None
 1.27A 3lp1A-2o8sA:
undetectable		 3lp1A-2o8sA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 ASN A 146
VAL A 141
TYR A 152
GLY A 145
TYR A 201
 None
 1.47A 3lp1A-2ph3A:
undetectable		 3lp1A-2ph3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbx EPHRIN TYPE-B
RECEPTOR 2

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 ASN A  79
VAL A  69
TYR A  67
GLY A  50
TRP A  43
 None
 1.48A 3lp1A-2qbxA:
undetectable		 3lp1A-2qbxA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		5 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.20A 3lp1A-2qjoA:
undetectable		 3lp1A-2qjoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 LEU A 140
VAL A   5
VAL A 104
GLY A 102
LEU A 124
 None
 1.37A 3lp1A-2qzxA:
undetectable		 3lp1A-2qzxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		5 LEU A 492
ASN A 494
VAL A 501
TRP A 465
LEU A 469
 None
 1.40A 3lp1A-2v9pA:
undetectable		 3lp1A-2v9pA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.43A 3lp1A-2vadA:
undetectable		 3lp1A-2vadA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE

(Pseudomonas
fluorescens) 		PF00378
(ECH_1) 		5 LEU C  24
ASN C 114
VAL C 113
GLY C 115
LEU C  59
 None
 1.19A 3lp1A-2vsuC:
undetectable		 3lp1A-2vsuC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		5 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.29A 3lp1A-2z06A:
undetectable		 3lp1A-2z06A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.33A 3lp1A-3a5wA:
undetectable		 3lp1A-3a5wA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		5 ASN A 650
VAL A 365
TYR A 368
GLY A 649
LEU A 375
 None
 1.36A 3lp1A-3abzA:
undetectable		 3lp1A-3abzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.15A 3lp1A-3anyA:
undetectable		 3lp1A-3anyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.09A 3lp1A-3b4tA:
undetectable		 3lp1A-3b4tA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		5 ASN A 133
VAL A  20
VAL A  25
GLY A  21
LEU A  97
 GNP  A 195 (-3.2A)
GNP  A 195 ( 4.1A)
None
GNP  A 195 (-3.3A)
None
 1.43A 3lp1A-3bc1A:
undetectable		 3lp1A-3bc1A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.09A 3lp1A-3dd6A:
undetectable		 3lp1A-3dd6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 196
VAL A  24
VAL A  17
GLY A 189
LEU A  99
 None
 1.18A 3lp1A-3eoqA:
2.9		 3lp1A-3eoqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxu EPHRIN TYPE-A
RECEPTOR 4

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 ASN A  54
VAL A  44
TYR A  42
GLY A  25
TRP A  17
 None
 1.45A 3lp1A-3gxuA:
undetectable		 3lp1A-3gxuA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hei EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 ASN A  52
VAL A  42
TYR A  40
GLY A  24
TRP A  16
 None
 1.49A 3lp1A-3heiA:
undetectable		 3lp1A-3heiA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 LEU A  15
ASN A  99
VAL A  98
GLY A 100
LEU A  50
 None
 1.28A 3lp1A-3hrxA:
2.0		 3lp1A-3hrxA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		5 ASN A 190
VAL A  30
VAL A  35
GLY A  31
LEU A 165
 ADP  A 301 (-2.9A)
ADP  A 301 (-4.4A)
None
ADP  A 301 (-3.1A)
None
 1.33A 3lp1A-3kb1A:
undetectable		 3lp1A-3kb1A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.27A 3lp1A-3ov3A:
undetectable		 3lp1A-3ov3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 ASN A 295
VAL A 267
TYR A 302
GLY A 266
LEU A  56
 None
 1.47A 3lp1A-3pplA:
undetectable		 3lp1A-3pplA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 LEU A  18
ASN A 102
VAL A 101
GLY A 103
LEU A  53
 None
 1.26A 3lp1A-3qxzA:
undetectable		 3lp1A-3qxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sei CASKIN-1

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU A  21
ASN A  25
VAL A  49
GLY A  48
LEU A  19
 None
 1.23A 3lp1A-3seiA:
undetectable		 3lp1A-3seiA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sen CASKIN-1

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU A  24
ASN A  28
VAL A  52
GLY A  51
LEU A  22
 None
 1.22A 3lp1A-3senA:
undetectable		 3lp1A-3senA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skj EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 ASN E  55
VAL E  45
TYR E  43
GLY E  27
TRP E  19
 None
 1.50A 3lp1A-3skjE:
undetectable		 3lp1A-3skjE:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy6 FIMBRIAL PROTEIN
BF1861

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		5 LEU A 116
ASN A  69
TYR A 131
GLY A  55
TYR A 107
 None
 1.43A 3lp1A-3sy6A:
undetectable		 3lp1A-3sy6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		5 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.42A 3lp1A-3uitA:
undetectable		 3lp1A-3uitA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.48A 3lp1A-3vreB:
undetectable		 3lp1A-3vreB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		5 ASN A  92
VAL A  93
TYR A  48
GLY A  23
LEU A  67
 None
 0.97A 3lp1A-3zscA:
undetectable		 3lp1A-3zscA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 LEU A 262
TYR A 323
GLY A 296
LEU A 236
TYR A 207
 None
 1.34A 3lp1A-4axnA:
undetectable		 3lp1A-4axnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		5 ASN A 158
VAL A 126
TYR A 152
GLY A 127
LEU A 135
 None
 1.49A 3lp1A-4c1lA:
undetectable		 3lp1A-4c1lA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4et7 EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 ASN A 111
VAL A 101
TYR A  99
GLY A  82
TRP A  75
 None
 1.28A 3lp1A-4et7A:
undetectable		 3lp1A-4et7A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 LEU A 170
TYR A 177
GLY A 190
LEU A 145
TYR A 166
 None
 1.32A 3lp1A-4f1hA:
undetectable		 3lp1A-4f1hA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE

(Rhodobacter
sphaeroides) 		PF02230
(Abhydrolase_2) 		5 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.36A 3lp1A-4ftwA:
undetectable		 3lp1A-4ftwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides) 		no annotation 5 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.46A 3lp1A-4hehA:
undetectable		 3lp1A-4hehA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.48A 3lp1A-4hh1A:
2.6		 3lp1A-4hh1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr3 PUTATIVE ACYL-COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 130
ASN A 113
VAL A 116
GLY A 112
LEU A 134
 None
 1.46A 3lp1A-4hr3A:
undetectable		 3lp1A-4hr3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		5 LEU A 180
VAL A  87
VAL A 420
GLY A 165
TYR A 182
 None
 1.29A 3lp1A-4jndA:
undetectable		 3lp1A-4jndA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		5 ASN A 153
VAL A  96
TYR A  92
GLY A 101
LEU A  45
 None
 1.45A 3lp1A-4jreA:
undetectable		 3lp1A-4jreA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxb INVASION-ASSOCIATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.24A 3lp1A-4jxbA:
undetectable		 3lp1A-4jxbA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0p EPHRIN TYPE-A
RECEPTOR 3

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 ASN A  80
VAL A  70
TYR A  68
GLY A  51
TRP A  44
 None
 1.16A 3lp1A-4l0pA:
undetectable		 3lp1A-4l0pA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
 None
 1.46A 3lp1A-4lecA:
undetectable		 3lp1A-4lecA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4r EPHRIN TYPE-A
RECEPTOR 4

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		5 ASN A  82
VAL A  72
TYR A  70
GLY A  53
TRP A  45
 None
 1.45A 3lp1A-4m4rA:
undetectable		 3lp1A-4m4rA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.46A 3lp1A-4m5pA:
undetectable		 3lp1A-4m5pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 LEU A 467
ASN A 430
VAL A 404
GLY A 411
LEU A 475
 None
 1.38A 3lp1A-4nk6A:
undetectable		 3lp1A-4nk6A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus) 		PF07992
(Pyr_redox_2) 		5 LEU A 146
VAL A 161
VAL A 159
TYR A 143
GLY A 160
 None
 1.45A 3lp1A-4ntcA:
undetectable		 3lp1A-4ntcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 LEU A 467
ASN A 430
VAL A 404
GLY A 411
LEU A 475
 None
 1.39A 3lp1A-4ozyA:
undetectable		 3lp1A-4ozyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		5 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.41A 3lp1A-4p6bA:
undetectable		 3lp1A-4p6bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 LEU A  91
VAL A 220
VAL A  82
TRP A  72
LEU A 229
 None
 1.45A 3lp1A-4q2cA:
undetectable		 3lp1A-4q2cA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		5 LEU A 153
ASN A 158
TYR A 151
GLY A 160
LEU A 663
 None
 1.36A 3lp1A-4s3pA:
undetectable		 3lp1A-4s3pA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 LEU A 443
VAL A 410
VAL A 396
GLY A 397
LEU A 445
 None
 1.46A 3lp1A-4uwqA:
undetectable		 3lp1A-4uwqA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.34A 3lp1A-4wjsA:
undetectable		 3lp1A-4wjsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
 None
 1.34A 3lp1A-4xiiA:
undetectable		 3lp1A-4xiiA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9a TRIOSEPHOSPHATE
ISOMERASE

(Streptomyces
coelicolor) 		PF00121
(TIM) 		5 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.40A 3lp1A-4y9aA:
undetectable		 3lp1A-4y9aA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 VAL B 106
VAL B 179
TYR B 181
TYR B 188
GLY B 190
 None
 0.54A 3lp1A-5c24B:
11.8		 3lp1A-5c24B:
96.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 LEU H 154
VAL H  13
VAL H   4
TYR H 124
LEU H 146
 None
 0.99A 3lp1A-5fg9H:
undetectable		 3lp1A-5fg9H:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 ASN A 219
VAL A 195
VAL A 294
GLY A 204
TYR A 272
 None
 1.22A 3lp1A-5lmzA:
undetectable		 3lp1A-5lmzA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 LEU A 273
ASN A 219
VAL A 195
VAL A 294
GLY A 204
 None
 1.02A 3lp1A-5lmzA:
undetectable		 3lp1A-5lmzA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 LEU A 453
VAL A 442
VAL A 406
TYR A 425
GLY A 407
 None
 1.47A 3lp1A-5m11A:
undetectable		 3lp1A-5m11A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
 None
 1.45A 3lp1A-5mg5A:
undetectable		 3lp1A-5mg5A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 LEU A 471
VAL A 622
TYR A 620
GLY A 579
LEU A 361
 None
 1.15A 3lp1A-5n6vA:
undetectable		 3lp1A-5n6vA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmy LYSOSTAPHIN

(Staphylococcus
simulans) 		no annotation 5 LEU A 361
VAL A 282
TYR A 327
GLY A 281
LEU A 258
 None
 1.45A 3lp1A-5nmyA:
undetectable		 3lp1A-5nmyA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okz EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		5 ASN H 228
VAL H 227
VAL H 113
TYR H 191
GLY H 226
 None
 1.48A 3lp1A-5okzH:
undetectable		 3lp1A-5okzH:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 5 LEU A  78
VAL A  24
GLY A  21
LEU A  81
TYR A  64
 None
 1.47A 3lp1A-5w1eA:
undetectable		 3lp1A-5w1eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 VAL A   7
TYR A 411
TYR A 415
GLY A  11
LEU A 381
 None
 1.47A 3lp1A-5xbpA:
1.1		 3lp1A-5xbpA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 5 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.38A 3lp1A-6b7kA:
undetectable		 3lp1A-6b7kA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU I 284
VAL I 236
TYR I 234
GLY I 262
TYR I   9
 None
 1.45A 3lp1A-6esqI:
undetectable		 3lp1A-6esqI:
9.73