SIMILAR PATTERNS OF AMINO ACIDS FOR 3LOQ_A_ACTA278_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1an4 PROTEIN (UPSTREAM
STIMULATORY FACTOR)

(Homo sapiens) 		PF00010
(HLH) 		3 SER A 230
GLY A 242
SER A 223
 None
 0.61A 3loqA-1an4A:
undetectable		 3loqA-1an4A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 333
GLY A 304
SER A 219
 None
 0.63A 3loqA-1b3nA:
undetectable		 3loqA-1b3nA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 SER A 192
GLY A 172
SER A 216
 None
 0.60A 3loqA-1d0bA:
undetectable		 3loqA-1d0bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1doq RNA POLYMERASE ALPHA
SUBUNIT

(Thermus
thermophilus) 		PF03118
(RNA_pol_A_CTD) 		3 SER A 298
GLY A 295
SER A 268
 None
 0.68A 3loqA-1doqA:
undetectable		 3loqA-1doqA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 SER B  20
GLY B  11
SER B  96
 None
 0.61A 3loqA-1e4eB:
1.6		 3loqA-1e4eB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 337
GLY A 308
SER A 223
 None
 0.59A 3loqA-1e5mA:
undetectable		 3loqA-1e5mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		3 SER A 226
GLY A 200
SER A 232
 FAD  A 399 (-2.7A)
FAD  A 399 (-3.4A)
None
 0.68A 3loqA-1efpA:
3.6		 3loqA-1efpA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		3 SER A 155
GLY A 152
SER A 118
 None
 0.44A 3loqA-1gzjA:
2.9		 3loqA-1gzjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 SER D 675
GLY D 679
SER D 511
 None
 0.63A 3loqA-1hqrD:
undetectable		 3loqA-1hqrD:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 331
GLY A 302
SER A 217
 None
 0.66A 3loqA-1j3nA:
undetectable		 3loqA-1j3nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 SER A 275
GLY A 302
SER A 280
 None
 0.56A 3loqA-1jr1A:
undetectable		 3loqA-1jr1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		3 SER A 117
GLY A 115
SER A 123
 None
 0.66A 3loqA-1m54A:
2.9		 3loqA-1m54A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		3 SER A 192
GLY A 172
SER A 216
 None
 0.62A 3loqA-1m9sA:
undetectable		 3loqA-1m9sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 SER A 598
GLY A 588
SER A 517
 None
 0.62A 3loqA-1ms8A:
undetectable		 3loqA-1ms8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 SER A 599
GLY A 589
SER A 518
 None
 0.69A 3loqA-1mz5A:
undetectable		 3loqA-1mz5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4t PUTATIVE OXALATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		3 SER A  57
GLY A  25
SER A 103
 None
 0.65A 3loqA-1o4tA:
undetectable		 3loqA-1o4tA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF00878
(CIMR) 		3 SER A  59
GLY A  61
SER A  44
 None
 0.52A 3loqA-1q25A:
undetectable		 3loqA-1q25A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 339
GLY A 310
SER A 225
 None
 0.64A 3loqA-1tqyA:
undetectable		 3loqA-1tqyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		3 SER A  12
GLY A 205
SER A 208
 None
 0.65A 3loqA-1uf3A:
undetectable		 3loqA-1uf3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z81 CYCLOPHILIN

(Plasmodium
yoelii) 		PF00160
(Pro_isomerase) 		3 SER A 117
GLY A 151
SER A 145
 None
 0.62A 3loqA-1z81A:
undetectable		 3loqA-1z81A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 SER A 562
GLY A 595
SER A 591
 None
 0.51A 3loqA-2cfzA:
undetectable		 3loqA-2cfzA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN

(Aeropyrum
pernix) 		no annotation 3 SER A  21
GLY A  71
SER A  25
 None
 0.58A 3loqA-2cxhA:
undetectable		 3loqA-2cxhA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		3 SER A 331
GLY A 327
SER A 289
 None
 0.67A 3loqA-2eidA:
undetectable		 3loqA-2eidA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		3 SER A 460
GLY A 456
SER A 162
 None
 0.66A 3loqA-2euhA:
4.4		 3loqA-2euhA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 SER A 258
GLY A 255
SER A 189
 None
1PE  A1262 ( 3.8A)
None
 0.66A 3loqA-2fafA:
undetectable		 3loqA-2fafA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 SER A 417
GLY A 454
SER A 412
 None
 0.63A 3loqA-2h2qA:
undetectable		 3loqA-2h2qA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		3 SER A  20
GLY A  16
SER A 189
 None
MG  A 374 (-3.5A)
None
 0.63A 3loqA-2hmaA:
3.8		 3loqA-2hmaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igs HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF11508
(DUF3218) 		3 SER A 133
GLY A 145
SER A 141
 None
 0.68A 3loqA-2igsA:
undetectable		 3loqA-2igsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		3 SER A   7
GLY A  -1
SER A  13
 None
 0.62A 3loqA-2iipA:
3.2		 3loqA-2iipA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipa THIOREDOXIN
PROTEIN ARSC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00085
(Thioredoxin)
PF01451
(LMWPc) 		3 SER B  69
GLY A  68
SER A  71
 None
 0.56A 3loqA-2ipaB:
undetectable		 3loqA-2ipaB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kv3 REGENERATING
ISLET-DERIVED
PROTEIN 4

(Homo sapiens) 		PF00059
(Lectin_C) 		3 SER A 116
GLY A  98
SER A  95
 None
 0.66A 3loqA-2kv3A:
undetectable		 3loqA-2kv3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj4 PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE/ROTAMASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00639
(Rotamase) 		3 SER A  63
GLY A  74
SER A  57
 None
 0.65A 3loqA-2lj4A:
undetectable		 3loqA-2lj4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6r FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		3 SER A  78
GLY A  74
SER A  42
 None
 0.69A 3loqA-2m6rA:
3.1		 3loqA-2m6rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9a ACETATE OPERON
REPRESSOR

(Escherichia
coli) 		PF01614
(IclR) 		3 SER A  65
GLY A  68
SER A 145
 PYR  A 905 (-4.3A)
None
PYR  A 905 (-2.7A)
 0.62A 3loqA-2o9aA:
undetectable		 3loqA-2o9aA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A  31
GLY A  48
SER A 299
 None
 0.66A 3loqA-2p88A:
3.7		 3loqA-2p88A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi REGULATOR OF
G-PROTEIN SIGNALING
9
GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus;
Mus musculus) 		PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma)
PF00400
(WD40) 		3 SER A 251
GLY B 295
SER B 250
 None
 0.59A 3loqA-2pbiA:
undetectable		 3loqA-2pbiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 SER A 209
GLY A 142
SER A 202
 None
 0.68A 3loqA-2pi5A:
undetectable		 3loqA-2pi5A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 330
GLY A 304
SER A 219
 None
 0.57A 3loqA-2rjtA:
undetectable		 3loqA-2rjtA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5p CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00040
(fn2)
PF00878
(CIMR) 		3 SER A1865
GLY A1890
SER A1951
 None
 0.68A 3loqA-2v5pA:
undetectable		 3loqA-2v5pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE

(Staphylococcus
aureus) 		PF00884
(Sulfatase) 		3 SER A 301
GLY A 298
SER A 321
 None
 0.62A 3loqA-2w5sA:
undetectable		 3loqA-2w5sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		3 SER A 377
GLY A 384
SER A 347
 None
 0.69A 3loqA-2wn4A:
undetectable		 3loqA-2wn4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER B 195
GLY B 213
SER B 199
 None
None
ANP  B 432 (-3.6A)
 0.66A 3loqA-2wtkB:
undetectable		 3loqA-2wtkB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 SER A 217
GLY A 287
SER A 298
 None
 0.65A 3loqA-2ybuA:
undetectable		 3loqA-2ybuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 SER A 415
GLY A 389
SER A 392
 None
 0.36A 3loqA-2z63A:
undetectable		 3loqA-2z63A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 SER A 415
GLY A 389
SER A 392
 None
 0.57A 3loqA-2z66A:
undetectable		 3loqA-2z66A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		3 SER A 381
GLY A 263
SER A 275
 None
 0.54A 3loqA-3al8A:
undetectable		 3loqA-3al8A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		3 SER A 711
GLY A 708
SER A 638
 None
 0.48A 3loqA-3aqpA:
undetectable		 3loqA-3aqpA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		3 SER A 578
GLY A 574
SER A 257
 None
 0.55A 3loqA-3ayfA:
undetectable		 3loqA-3ayfA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		3 SER A 640
GLY A 113
SER A 635
 None
None
WCC  A 811 (-3.2A)
 0.68A 3loqA-3cf4A:
2.3		 3loqA-3cf4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 SER A 486
GLY A 488
SER A 492
 None
 0.69A 3loqA-3cghA:
undetectable		 3loqA-3cghA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		3 SER A 200
GLY A 227
SER A 219
 None
 0.52A 3loqA-3d02A:
2.8		 3loqA-3d02A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		3 SER A  69
GLY A 404
SER A 102
 None
 0.69A 3loqA-3do6A:
1.7		 3loqA-3do6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 340
GLY A 312
SER A 227
 None
 0.63A 3loqA-3e60A:
undetectable		 3loqA-3e60A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 SER A  93
GLY A 180
SER A 192
 None
 0.63A 3loqA-3girA:
undetectable		 3loqA-3girA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		3 SER A  46
GLY A  39
SER A 366
 None
None
EDO  A 396 ( 4.8A)
 0.69A 3loqA-3h1wA:
undetectable		 3loqA-3h1wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		3 SER A 116
GLY A  50
SER A 119
 None
 0.41A 3loqA-3h4yA:
2.0		 3loqA-3h4yA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		3 SER A  83
GLY A  85
SER A 237
 None
 0.65A 3loqA-3h5qA:
1.9		 3loqA-3h5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		3 SER A 206
GLY A 254
SER A 101
 None
 0.64A 3loqA-3hidA:
undetectable		 3loqA-3hidA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		3 SER A 150
GLY A 162
SER A 185
 None
 0.66A 3loqA-3i0pA:
undetectable		 3loqA-3i0pA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME

(Corynebacterium
glutamicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 285
GLY A 281
SER A 314
 SER  A 285 ( 0.0A)
GLY  A 281 ( 0.0A)
SER  A 314 ( 0.0A)
 0.55A 3loqA-3i4kA:
3.7		 3loqA-3i4kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia7 CALG4

(Micromonospora
echinospora) 		PF00201
(UDPGT) 		3 SER A 382
GLY A 211
SER A 195
 None
 0.63A 3loqA-3ia7A:
4.2		 3loqA-3ia7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		3 SER B 117
GLY B 114
SER B 169
 None
 0.66A 3loqA-3iqdB:
2.6		 3loqA-3iqdB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9t PUTATIVE PEPTIDASE

(Clostridium
acetobutylicum) 		PF09940
(DUF2172)
PF16221
(HTH_47)
PF16254
(DUF4910) 		3 SER A 341
GLY A 337
SER A 198
 None
 0.65A 3loqA-3k9tA:
undetectable		 3loqA-3k9tA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 SER A 407
GLY A 444
SER A 402
 None
 0.53A 3loqA-3kjrA:
undetectable		 3loqA-3kjrA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkr INTEGRASE

(Bovine
immunodeficiency
virus) 		PF00665
(rve) 		3 SER A 202
GLY A  57
SER A  81
 None
 0.49A 3loqA-3kkrA:
undetectable		 3loqA-3kkrA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 340
GLY A 312
SER A 227
 None
 0.60A 3loqA-3kzuA:
undetectable		 3loqA-3kzuA:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loq UNIVERSAL STRESS
PROTEIN

(Archaeoglobus
fulgidus) 		PF00582
(Usp) 		3 SER A 107
GLY A 109
SER A 120
 CL  A 273 (-2.9A)
CL  A 273 ( 3.7A)
AMP  A 271 (-2.6A)
 0.53A 3loqA-3loqA:
49.7		 3loqA-3loqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loq UNIVERSAL STRESS
PROTEIN

(Archaeoglobus
fulgidus) 		PF00582
(Usp) 		3 SER A 235
GLY A 237
SER A 248
 ACT  A 279 ( 3.2A)
ACT  A 278 (-3.4A)
ACT  A 279 ( 4.2A)
 0.00A 3loqA-3loqA:
49.7		 3loqA-3loqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 3 SER A 417
GLY A 443
SER A 449
 None
 0.60A 3loqA-3ly9A:
undetectable		 3loqA-3ly9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 SER A 115
GLY A  80
SER A 103
 None
 0.58A 3loqA-3n7zA:
undetectable		 3loqA-3n7zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 170
GLY A 106
SER A 158
 None
 0.65A 3loqA-3o04A:
undetectable		 3loqA-3o04A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		3 SER A 383
GLY A 262
SER A 273
 None
 0.65A 3loqA-3ol2A:
undetectable		 3loqA-3ol2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 106
GLY A 109
SER A  74
 None
 0.48A 3loqA-3oytA:
undetectable		 3loqA-3oytA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 327
GLY A 300
SER A 220
 None
 0.66A 3loqA-3oytA:
undetectable		 3loqA-3oytA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8y NUCLEOSIDE
DIPHOSPHATE KINASE

(Staphylococcus
aureus) 		PF00334
(NDK) 		3 SER A 100
GLY A 103
SER A  90
 None
 0.57A 3loqA-3q8yA:
undetectable		 3loqA-3q8yA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		3 SER A  21
GLY A 308
SER A 302
 None
 0.53A 3loqA-3qe7A:
undetectable		 3loqA-3qe7A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1b TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio cholerae) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		3 SER A 167
GLY A 230
SER A 172
 None
 0.57A 3loqA-3t1bA:
undetectable		 3loqA-3t1bA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 SER A 225
GLY A 222
SER A 229
 None
 0.64A 3loqA-3tefA:
2.9		 3loqA-3tefA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 SER A1345
GLY A1583
SER A1477
 None
 0.62A 3loqA-3va7A:
6.0		 3loqA-3va7A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		3 SER A 234
GLY A 231
SER A 247
 EDO  A1003 ( 4.4A)
ACT  A1002 (-3.3A)
EDO  A1003 (-4.4A)
 0.67A 3loqA-3vqrA:
2.2		 3loqA-3vqrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		3 SER A 449
GLY A 451
SER A 405
 SSA  A2002 (-3.1A)
SSA  A2002 (-3.4A)
None
 0.56A 3loqA-3w3sA:
undetectable		 3loqA-3w3sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbr C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER C

(Homo sapiens) 		PF00059
(Lectin_C) 		3 SER A  98
GLY A 100
SER A 107
 None
 0.59A 3loqA-3wbrA:
undetectable		 3loqA-3wbrA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 SER A1055
GLY A1052
SER A1014
 None
 0.63A 3loqA-4a5wA:
undetectable		 3loqA-4a5wA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater) 		PF06722
(DUF1205) 		3 SER A 103
GLY A 129
SER A  20
 None
 0.58A 3loqA-4amgA:
4.1		 3loqA-4amgA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		3 SER A 530
GLY A 524
SER A 444
 None
None
MLI  A1599 (-3.3A)
 0.49A 3loqA-4b2gA:
undetectable		 3loqA-4b2gA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cil YOPM-CAP, INTERNALIN
B

(Yersinia
enterocolitica;
Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12468
(TTSSLRR)
PF12799
(LRR_4) 		3 SER A 192
GLY A 172
SER A 216
 None
 0.48A 3loqA-4cilA:
undetectable		 3loqA-4cilA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 SER A 644
GLY A 621
SER A 625
 None
 0.68A 3loqA-4cu8A:
undetectable		 3loqA-4cu8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		3 SER A 559
GLY A 525
SER A 556
 None
 0.68A 3loqA-4d72A:
2.4		 3loqA-4d72A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 SER A 450
GLY A 437
SER A 445
 None
 0.53A 3loqA-4fffA:
undetectable		 3loqA-4fffA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 SER A 144
GLY A 140
SER A 199
 None
 0.62A 3loqA-4g1pA:
undetectable		 3loqA-4g1pA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 3 SER A 177
GLY A 152
SER A 159
 None
 0.66A 3loqA-4g4iA:
undetectable		 3loqA-4g4iA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 SER A 295
GLY A 343
SER A 363
 None
 0.66A 3loqA-4hxxA:
undetectable		 3loqA-4hxxA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 SER A 295
GLY A 343
SER A 363
 None
 0.54A 3loqA-4iu6A:
undetectable		 3loqA-4iu6A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A  82
GLY A  78
SER A 144
 None
 0.63A 3loqA-4jb6A:
undetectable		 3loqA-4jb6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 334
GLY A 305
SER A 220
 None
 0.58A 3loqA-4jb6A:
undetectable		 3loqA-4jb6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER A 348
GLY A 319
SER A 234
 None
 0.57A 3loqA-4jgaA:
undetectable		 3loqA-4jgaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 3 SER D 335
GLY D 305
SER D 220
 None
 0.60A 3loqA-4jrmD:
undetectable		 3loqA-4jrmD:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		3 SER A 336
GLY A 305
SER A 293
 None
 0.67A 3loqA-4kpgA:
undetectable		 3loqA-4kpgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Brachyspira
murdochii) 		PF13407
(Peripla_BP_4) 		3 SER A 172
GLY A 175
SER A 115
 None
 0.62A 3loqA-4kqcA:
2.3		 3loqA-4kqcA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 SER A 303
GLY A 138
SER A 346
 None
CL  A 401 (-4.0A)
None
 0.68A 3loqA-4lcbA:
undetectable		 3loqA-4lcbA:
25.26