SIMILAR PATTERNS OF AMINO ACIDS FOR 3LN1_D_CELD682_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ARG A 108
LEU A 122
ILE A 130
PHE A 126
 None
 1.18A 3ln1D-1b3bA:
0.0		 3ln1D-1b3bA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0g MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE D

(Escherichia
coli) 		PF01476
(LysM) 		4 ARG A   8
LEU A  13
ARG A  19
ILE A   3
 None
 1.22A 3ln1D-1e0gA:
undetectable		 3ln1D-1e0gA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster) 		PF02469
(Fasciclin) 		4 LEU A 471
ARG A 502
ILE A 546
PHE A 503
 None
 1.14A 3ln1D-1o70A:
0.0		 3ln1D-1o70A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5q PROTEASOME BETA-TYPE
SUBUNIT 1

(Rhodococcus
erythropolis) 		PF00227
(Proteasome) 		4 ARG H  88
LEU H  55
ARG H  82
PHE H  59
 None
 1.30A 3ln1D-1q5qH:
0.0		 3ln1D-1q5qH:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		4 ARG B 114
ARG B  95
ILE B  83
PHE B  94
 None
 1.10A 3ln1D-1r4nB:
0.0		 3ln1D-1r4nB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s05 CYTOCHROME C-556

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		4 ARG A 125
LEU A  51
ILE A 113
PHE A  89
 HEM  A 130 (-4.5A)
None
None
HEM  A 130 (-2.2A)
 1.23A 3ln1D-1s05A:
undetectable		 3ln1D-1s05A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		4 ARG A 117
LEU A 121
ARG A 176
ILE A 174
 NAP  A 481 ( 4.8A)
None
NAP  A 481 (-3.6A)
None
 1.23A 3ln1D-1tdfA:
0.0		 3ln1D-1tdfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k GTP-BINDING PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		4 ARG A 138
LEU A 118
ARG A  93
ILE A  90
 None
 1.22A 3ln1D-1z0kA:
0.0		 3ln1D-1z0kA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl7 ENTEROCINE A
IMMUNITY PROTEIN

(Enterococcus
faecium) 		PF08951
(EntA_Immun) 		4 ARG A  78
LEU A  12
ILE A  67
PHE A  69
 None
 1.26A 3ln1D-2bl7A:
undetectable		 3ln1D-2bl7A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9j GREEN FLUORESCENT
PROTEIN FP512

(Cerianthus
membranaceus) 		PF01353
(GFP) 		4 LEU A  40
ARG A  66
ILE A 107
PHE A  65
 CRQ  A  62 ( 4.6A)
CRQ  A  62 ( 4.0A)
None
CRQ  A  62 ( 3.7A)
 1.23A 3ln1D-2c9jA:
0.0		 3ln1D-2c9jA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfa THYMIDYLATE SYNTHASE

(Paramecium
bursaria
Chlorella virus
1) 		PF02511
(Thy1) 		4 LEU B 213
ARG B 173
ILE B  56
PHE B  57
 None
FAD  B1217 ( 3.9A)
None
None
 1.14A 3ln1D-2cfaB:
0.0		 3ln1D-2cfaB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Schistosoma
mansoni) 		PF00160
(Pro_isomerase) 		4 ARG A  12
LEU A 105
ILE A 165
PHE A  15
 None
 1.23A 3ln1D-2cmtA:
undetectable		 3ln1D-2cmtA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbg MYELOID CELL NUCLEAR
DIFFERENTIATION
ANTIGEN

(Homo sapiens) 		PF02758
(PYRIN) 		4 LEU A  85
ARG A  52
ILE A  55
PHE A  21
 None
 1.22A 3ln1D-2dbgA:
undetectable		 3ln1D-2dbgA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7v TRANSMEMBRANE
PROTEASE

(Mus musculus) 		PF01390
(SEA) 		4 ARG A 121
ARG A  89
ILE A  84
PHE A  88
 None
 1.07A 3ln1D-2e7vA:
undetectable		 3ln1D-2e7vA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS 3

(Rattus
norvegicus) 		PF00536
(SAM_1) 		4 LEU A  19
ARG A  25
ILE A  31
PHE A  26
 None
 1.01A 3ln1D-2f3nA:
undetectable		 3ln1D-2f3nA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ARG A 728
LEU A 290
ILE A 616
PHE A 278
 None
 1.28A 3ln1D-2g8gA:
undetectable		 3ln1D-2g8gA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF13638
(PIN_4) 		4 LEU A1266
ARG A1321
ILE A1338
PHE A1318
 None
 0.99A 3ln1D-2hwxA:
undetectable		 3ln1D-2hwxA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0i DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 ARG A 464
LEU A 468
ILE A 479
PHE A 477
 None
 1.29A 3ln1D-2i0iA:
undetectable		 3ln1D-2i0iA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja1 THYMIDINE KINASE

(Bacillus cereus) 		PF00265
(TK) 		4 ARG A 121
LEU A 116
ILE A  46
PHE A  92
 None
MPD  A1194 (-4.6A)
None
MPD  A1194 (-4.9A)
 1.20A 3ln1D-2ja1A:
undetectable		 3ln1D-2ja1A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ARG A  36
LEU A   5
ARG A  15
ILE A  13
 None
 1.30A 3ln1D-2ng1A:
undetectable		 3ln1D-2ng1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 172
LEU A 181
ILE A 230
PHE A 226
 None
 1.14A 3ln1D-2ox4A:
undetectable		 3ln1D-2ox4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pau 5'-DEOXYNUCLEOTIDASE
YFBR

(Escherichia
coli) 		PF13023
(HD_3) 		4 LEU A  10
ARG A 113
ILE A 115
PHE A 116
 None
 1.16A 3ln1D-2pauA:
undetectable		 3ln1D-2pauA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		4 ARG A 110
LEU A  52
ARG A  64
PHE A  63
 None
 1.22A 3ln1D-2psyA:
undetectable		 3ln1D-2psyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 ARG A 255
LEU A 267
ILE A  18
PHE A 272
 None
 1.04A 3ln1D-2r98A:
undetectable		 3ln1D-2r98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 ARG A   9
LEU A  17
ILE A  34
PHE A  25
 None
 1.24A 3ln1D-2tptA:
undetectable		 3ln1D-2tptA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ARG A 224
LEU A 191
ILE A 141
PHE A 132
 IN5  A1394 ( 3.8A)
None
None
None
 1.11A 3ln1D-2vd9A:
undetectable		 3ln1D-2vd9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		4 ARG A 357
LEU A 324
ILE A 345
PHE A 347
 None
 1.09A 3ln1D-2vrtA:
undetectable		 3ln1D-2vrtA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		4 ARG A 434
LEU A 359
ILE A 197
PHE A 198
 None
 1.30A 3ln1D-2w45A:
undetectable		 3ln1D-2w45A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780

(Pyrococcus
horikoshii) 		PF00571
(CBS) 		4 ARG A  33
LEU A 274
ARG A 114
ILE A   6
 None
 1.27A 3ln1D-2yzqA:
undetectable		 3ln1D-2yzqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  57
ARG A  31
ILE A 135
PHE A 101
 None
 1.18A 3ln1D-2z01A:
undetectable		 3ln1D-2z01A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.86A 3ln1D-2z1uA:
undetectable		 3ln1D-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		4 ARG A  32
LEU A  55
ARG A 127
ILE A 144
 None
None
DIO  A 991 (-3.2A)
None
 1.11A 3ln1D-3accA:
undetectable		 3ln1D-3accA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 ARG A 117
LEU A  14
ILE A  57
PHE A  35
 None
 1.04A 3ln1D-3b8lA:
undetectable		 3ln1D-3b8lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bem PUTATIVE NAD(P)H
NITROREDUCTASE YDFN

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		4 ARG A 166
LEU A  61
ILE A 157
PHE A 159
 None
None
FMN  A 300 (-4.0A)
None
 1.22A 3ln1D-3bemA:
undetectable		 3ln1D-3bemA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 ARG A 154
ARG A  64
ILE A  93
PHE A  89
 None
 1.22A 3ln1D-3bhwA:
undetectable		 3ln1D-3bhwA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Candida
albicans) 		PF01239
(PPTA) 		4 LEU A 189
ARG A 232
ILE A 229
PHE A 191
 None
 1.30A 3ln1D-3draA:
undetectable		 3ln1D-3draA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		4 ARG A1980
LEU A1832
ARG A1915
PHE A1914
 None
 0.95A 3ln1D-3edvA:
undetectable		 3ln1D-3edvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		4 LEU A 290
ARG A 253
ILE A 351
PHE A 254
 None
 1.16A 3ln1D-3f83A:
undetectable		 3ln1D-3f83A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f92 UBIQUITIN-CONJUGATIN
G ENZYME E2 K

(Homo sapiens) 		PF00179
(UQ_con)
PF00627
(UBA) 		4 LEU A 110
ARG A  74
ILE A  84
PHE A  75
 None
 1.30A 3ln1D-3f92A:
undetectable		 3ln1D-3f92A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ARG A 380
LEU A 154
ILE A 228
PHE A 224
 None
 1.16A 3ln1D-3gwjA:
undetectable		 3ln1D-3gwjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 LEU A 293
ARG A 338
ILE A   5
PHE A 339
 None
 1.12A 3ln1D-3hfqA:
undetectable		 3ln1D-3hfqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A  51
LEU A 145
ILE A 120
PHE A 116
 None
 1.14A 3ln1D-3ihvA:
undetectable		 3ln1D-3ihvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxt DISKS LARGE HOMOLOG
3

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 ARG A 403
LEU A 407
ILE A 418
PHE A 416
 None
 1.27A 3ln1D-3jxtA:
undetectable		 3ln1D-3jxtA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ARG A 730
LEU A 299
ILE A 618
PHE A 287
 None
 1.27A 3ln1D-3kieA:
undetectable		 3ln1D-3kieA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LEU A 751
ARG A 884
ILE A 888
PHE A 885
 None
SO4  A 910 (-4.6A)
None
None
 1.21A 3ln1D-3kulA:
undetectable		 3ln1D-3kulA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 ARG A  90
LEU A 253
ARG A 101
ILE A 105
 PAP  A 286 (-2.7A)
None
PAP  A 286 (-2.5A)
None
 0.98A 3ln1D-3mgbA:
undetectable		 3ln1D-3mgbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		4 ARG A 286
LEU A 224
ARG A 322
ILE A 296
 None
 1.24A 3ln1D-3n9xA:
1.0		 3ln1D-3n9xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 598
ARG A 493
ILE A 491
PHE A 494
 None
 1.23A 3ln1D-3nheA:
undetectable		 3ln1D-3nheA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  61
ARG A  36
ILE A 139
PHE A 105
 None
 1.23A 3ln1D-3p4eA:
undetectable		 3ln1D-3p4eA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2e BROMODOMAIN AND WD
REPEAT-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A1325
ARG A1339
ILE A1385
PHE A1360
 None
 1.22A 3ln1D-3q2eA:
undetectable		 3ln1D-3q2eA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY

(Homo sapiens) 		no annotation 4 ARG L  38
LEU L  45
ILE L  90
PHE L  85
 None
 1.25A 3ln1D-3rpiL:
undetectable		 3ln1D-3rpiL:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ARG A 730
LEU A 300
ILE A 618
PHE A 288
 None
 1.27A 3ln1D-3shmA:
undetectable		 3ln1D-3shmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 608
ARG A 633
ILE A 641
PHE A 606
 None
 1.20A 3ln1D-3sxsA:
undetectable		 3ln1D-3sxsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t38 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		4 ARG A  47
LEU A  55
ARG A  66
ILE A  38
 None
None
D1D  A3236 (-3.3A)
None
 1.19A 3ln1D-3t38A:
undetectable		 3ln1D-3t38A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 238
ARG A 250
ILE A 257
PHE A 188
 None
 1.21A 3ln1D-3v8dA:
0.0		 3ln1D-3v8dA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 280
ARG A 250
ILE A 187
PHE A 188
 None
 1.32A 3ln1D-3v8dA:
0.0		 3ln1D-3v8dA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgj TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Plasmodium
falciparum) 		PF00579
(tRNA-synt_1b) 		4 ARG A  68
LEU A 346
ARG A 268
ILE A 270
 None
 1.15A 3ln1D-3vgjA:
undetectable		 3ln1D-3vgjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		4 ARG A 460
LEU A 106
ARG A 429
ILE A 356
 None
 1.26A 3ln1D-4bmaA:
undetectable		 3ln1D-4bmaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		4 ARG B 307
LEU B 233
ARG B   6
ILE B   5
 None
 1.27A 3ln1D-4fwiB:
undetectable		 3ln1D-4fwiB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2o FIXK2 PROTEIN

(Bradyrhizobium
japonicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ARG A 170
LEU A 180
ILE A  82
PHE A  85
 None
 1.01A 3ln1D-4i2oA:
undetectable		 3ln1D-4i2oA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2k TRYPSIN INHIBITOR

(Enterolobium
contortisiliquum) 		PF00197
(Kunitz_legume) 		4 LEU A   3
ARG A 168
ILE A  19
PHE A 169
 None
GOL  A 202 (-3.7A)
None
None
 1.06A 3ln1D-4j2kA:
undetectable		 3ln1D-4j2kA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k91 D-ALA-D-ALA-CARBOXYP
EPTIDASE

(Pseudomonas
aeruginosa) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 ARG A 238
LEU A  45
ARG A 189
ILE A  99
 SIN  A 601 ( 4.8A)
None
SIN  A 601 ( 4.7A)
None
 1.19A 3ln1D-4k91A:
undetectable		 3ln1D-4k91A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 LEU A 470
ARG A 747
ILE A 752
PHE A 748
 None
 1.09A 3ln1D-4ka8A:
undetectable		 3ln1D-4ka8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		4 ARG A  69
LEU A 126
ARG A 102
ILE A 210
 None
 1.24A 3ln1D-4kujA:
undetectable		 3ln1D-4kujA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 ARG A 101
LEU A 389
ILE A 421
PHE A 460
 None
 1.07A 3ln1D-4lglA:
2.4		 3ln1D-4lglA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m29 BETA-XYLOSIDASE

(Caulobacter
vibrioides) 		PF01229
(Glyco_hydro_39) 		4 LEU A 357
ARG A  57
ILE A  30
PHE A  56
 None
 1.16A 3ln1D-4m29A:
undetectable		 3ln1D-4m29A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 ARG A 335
ARG A 304
ILE A 151
PHE A 303
 None
SO4  A 411 (-2.6A)
None
None
 1.08A 3ln1D-4o6mA:
undetectable		 3ln1D-4o6mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 ARG A  37
LEU A  26
ILE A 176
PHE A 193
 None
 1.24A 3ln1D-4p6yA:
undetectable		 3ln1D-4p6yA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ARG A 121
LEU A 385
ARG A 514
ILE A 518
PHE A 519
 BOG  A 604 ( 3.7A)
None
None
None
None
 0.43A 3ln1D-4ph9A:
63.8		 3ln1D-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 LEU A 508
ARG A 514
ILE A 518
PHE A 519
 None
 1.00A 3ln1D-4ph9A:
63.8		 3ln1D-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		4 LEU A 574
ARG A 628
ILE A 666
PHE A 629
 None
 1.26A 3ln1D-4pkvA:
undetectable		 3ln1D-4pkvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A3525
LEU A3551
ARG A3561
ILE A3559
 None
 1.30A 3ln1D-4rh7A:
undetectable		 3ln1D-4rh7A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 ARG A 688
LEU A 635
ILE A 369
PHE A 181
 None
 1.24A 3ln1D-4s3pA:
0.2		 3ln1D-4s3pA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ARG A 566
LEU A 558
ARG A 650
ILE A 677
 SO4  A1001 (-2.6A)
None
None
None
 1.27A 3ln1D-4xcuA:
undetectable		 3ln1D-4xcuA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5o MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3

(Homo sapiens) 		PF00564
(PB1) 		4 LEU B  81
ARG B  56
ILE B  47
PHE B  49
 None
 1.19A 3ln1D-4y5oB:
undetectable		 3ln1D-4y5oB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 736
LEU A 929
ILE A 583
PHE A 887
 None
 1.26A 3ln1D-5b7iA:
0.0		 3ln1D-5b7iA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ARG A 454
LEU A 306
ARG A 491
ILE A 298
 None
 1.15A 3ln1D-5d0fA:
undetectable		 3ln1D-5d0fA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP1

(Deformed wing
virus) 		PF08762
(CRPV_capsid) 		4 LEU A  70
ARG A  88
ILE A  83
PHE A  84
 None
 1.27A 3ln1D-5g52A:
undetectable		 3ln1D-5g52A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha4 DIAMINOPIMELATE
EPIMERASE

(Acinetobacter
baumannii) 		PF01678
(DAP_epimerase) 		4 ARG A 234
LEU A 207
ILE A 178
PHE A 196
 None
 1.29A 3ln1D-5ha4A:
undetectable		 3ln1D-5ha4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		4 LEU A  59
ARG A  55
ILE A  25
PHE A  54
 None
 1.32A 3ln1D-5hsxA:
undetectable		 3ln1D-5hsxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ARG A1145
LEU A1193
ILE A1207
PHE A1137
 None
 1.12A 3ln1D-5hy7A:
undetectable		 3ln1D-5hy7A:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ARG A 120
LEU A 384
ARG A 513
ILE A 517
PHE A 518
 ID8  A 601 ( 4.4A)
ID8  A 601 ( 4.8A)
None
None
None
 0.36A 3ln1D-5ikrA:
34.1		 3ln1D-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 LEU A 507
ARG A 513
ILE A 517
PHE A 518
 None
 0.87A 3ln1D-5ikrA:
34.1		 3ln1D-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04390
(LptE)
PF04453
(OstA_C) 		4 ARG B  75
LEU A 164
ILE A 151
PHE A 157
 None
 1.17A 3ln1D-5ivaB:
undetectable		 3ln1D-5ivaB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 ARG A 195
LEU A 173
ILE A 161
PHE A 184
 None
 1.29A 3ln1D-5ixpA:
undetectable		 3ln1D-5ixpA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ARG A 175
LEU A 187
ARG A 268
ILE A 270
 None
 1.17A 3ln1D-5jd4A:
undetectable		 3ln1D-5jd4A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 ARG A 562
LEU A 619
ARG A 703
ILE A 702
 None
 1.07A 3ln1D-5jz8A:
undetectable		 3ln1D-5jz8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ARG B 120
LEU B 100
ILE B 364
PHE B 365
 None
 1.23A 3ln1D-5l3rB:
undetectable		 3ln1D-5l3rB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ARG C 293
LEU C 280
ILE C 256
PHE C 251
 ARG  C 293 ( 0.6A)
LEU  C 280 ( 0.5A)
ILE  C 256 ( 0.7A)
PHE  C 251 ( 1.3A)
 1.25A 3ln1D-5lmxC:
undetectable		 3ln1D-5lmxC:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21

(Kluyveromyces
lactis) 		no annotation 4 LEU A 222
ARG A 247
ILE A 253
PHE A 246
 None
 1.26A 3ln1D-5mu3A:
0.7		 3ln1D-5mu3A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ARG A 727
LEU A 577
ARG A 552
ILE A 550
 None
 1.28A 3ln1D-5n6uA:
undetectable		 3ln1D-5n6uA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 ARG B 584
LEU B 316
ILE B 673
PHE B 615
 None
 1.07A 3ln1D-5swiB:
undetectable		 3ln1D-5swiB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 LEU 2 680
ARG 2 676
ILE 2 646
PHE 2 677
 None
 1.29A 3ln1D-5udb2:
undetectable		 3ln1D-5udb2:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		4 ARG A  59
LEU A  94
ILE A 123
PHE A 133
 None
 1.32A 3ln1D-5uhkA:
undetectable		 3ln1D-5uhkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  58
ARG A  33
ILE A 136
PHE A 102
 None
 1.27A 3ln1D-5vk4A:
undetectable		 3ln1D-5vk4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 ARG A 606
LEU A 706
ARG A  27
ILE A  30
 None
 1.28A 3ln1D-5whsA:
0.6		 3ln1D-5whsA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 ARG A 110
LEU A  97
ARG A  82
ILE A  84
 None
 1.09A 3ln1D-5x9gA:
undetectable		 3ln1D-5x9gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 LEU A 766
ARG A 758
ILE A 487
PHE A 488
 None
 0.91A 3ln1D-5xwyA:
undetectable		 3ln1D-5xwyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 270
ARG A 210
ILE A 237
PHE A 260
 None
 1.32A 3ln1D-6asoA:
undetectable		 3ln1D-6asoA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ARG A 575
LEU A 414
ILE A 644
PHE A 492
 None
 1.06A 3ln1D-6cgmA:
undetectable		 3ln1D-6cgmA:
8.39