SIMILAR PATTERNS OF AMINO ACIDS FOR 3LN1_C_CELC682_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		4 GLN A  96
SER A  70
LEU A  12
ILE A  74
 None
 0.88A 3ln1C-1c8uA:
0.0		 3ln1C-1c8uA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 0.98A 3ln1C-1d0bA:
undetectable		 3ln1C-1d0bA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ARG A 120
GLN A 192
SER A 353
LEU A 384
ILE A 517
 SCL  A 700 (-3.9A)
None
None
None
None
 0.44A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 192
SER A 353
LEU A 384
ILE A 517
PHE A 518
 None
 0.79A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 192
SER A 353
LEU A 507
ILE A 517
PHE A 518
 None
 1.21A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		5 GLN A 420
SER A 190
LEU A 552
ARG A 416
ILE A 414
 None
 1.47A 3ln1C-1fokA:
0.0		 3ln1C-1fokA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 SER A 156
LEU A 223
ILE A 160
PHE A 161
 None
 1.04A 3ln1C-1jd0A:
undetectable		 3ln1C-1jd0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		4 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 1.09A 3ln1C-1m9sA:
undetectable		 3ln1C-1m9sA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 SER A   7
LEU A  57
ILE A 175
PHE A   9
 None
 1.01A 3ln1C-1mozA:
0.0		 3ln1C-1mozA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 GLN A 227
SER A 195
LEU A 241
ILE A 230
 None
 0.97A 3ln1C-1oypA:
0.0		 3ln1C-1oypA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		4 SER A 635
LEU A 585
ARG A 641
PHE A 544
 None
 1.07A 3ln1C-1t6pA:
0.0		 3ln1C-1t6pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tke THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF02824
(TGS)
PF07973
(tRNA_SAD) 		4 SER A 154
LEU A 172
ARG A 145
ILE A 159
 None
 1.06A 3ln1C-1tkeA:
0.0		 3ln1C-1tkeA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 SER A1180
LEU A 998
ARG A1257
ILE A1177
 None
 1.03A 3ln1C-1tllA:
undetectable		 3ln1C-1tllA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux8 YJBI PROTEIN

(Bacillus
subtilis) 		PF01152
(Bac_globin) 		4 ARG A 107
SER A  91
LEU A  53
PHE A  24
 None
None
HEM  A 700 (-4.9A)
None
 1.06A 3ln1C-1ux8A:
undetectable		 3ln1C-1ux8A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A 404
GLN A 529
LEU A 507
ILE A  32
 None
 1.08A 3ln1C-1w6sA:
undetectable		 3ln1C-1w6sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 SER A 148
LEU A 204
ARG A 158
ILE A 153
PHE A 157
 None
 1.33A 3ln1C-1x8vA:
2.0		 3ln1C-1x8vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 407
LEU A 159
ARG A 119
ILE A 445
 None
None
ABW  A1000 (-3.2A)
None
 1.06A 3ln1C-1xogA:
undetectable		 3ln1C-1xogA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7v TRANSMEMBRANE
PROTEASE

(Mus musculus) 		PF01390
(SEA) 		4 ARG A 121
ARG A  89
ILE A  84
PHE A  88
 None
 1.05A 3ln1C-2e7vA:
undetectable		 3ln1C-2e7vA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS 3

(Rattus
norvegicus) 		PF00536
(SAM_1) 		4 LEU A  19
ARG A  25
ILE A  31
PHE A  26
 None
 1.01A 3ln1C-2f3nA:
undetectable		 3ln1C-2f3nA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF13638
(PIN_4) 		4 LEU A1266
ARG A1321
ILE A1338
PHE A1318
 None
 0.99A 3ln1C-2hwxA:
undetectable		 3ln1C-2hwxA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 SER A 151
LEU A 242
ARG A 153
ILE A 204
 None
 1.06A 3ln1C-2jgpA:
undetectable		 3ln1C-2jgpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		4 SER A  36
LEU A   7
ARG A 330
ILE A 328
 None
 1.04A 3ln1C-2pn1A:
undetectable		 3ln1C-2pn1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt5 SHIKIMATE KINASE

(Aquifex
aeolicus) 		PF01202
(SKI) 		4 ARG A  22
SER A  14
LEU A 158
ILE A  99
 None
 0.92A 3ln1C-2pt5A:
undetectable		 3ln1C-2pt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3s PROTEIN AT5G06450

(Arabidopsis
thaliana) 		no annotation 4 SER A 106
LEU A  87
ILE A 131
PHE A 104
 None
 0.99A 3ln1C-2q3sA:
undetectable		 3ln1C-2q3sA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 GLN A  93
LEU A  48
ILE A  84
PHE A  64
 None
 1.04A 3ln1C-2q9sA:
undetectable		 3ln1C-2q9sA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 ARG A 255
LEU A 267
ILE A  18
PHE A 272
 None
 1.04A 3ln1C-2r98A:
undetectable		 3ln1C-2r98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 510
ARG B 581
ILE B 506
PHE B 582
 None
 0.99A 3ln1C-2w55B:
undetectable		 3ln1C-2w55B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 SER A 272
LEU A 292
ILE A 277
PHE A 290
 None
 0.95A 3ln1C-2wyaA:
undetectable		 3ln1C-2wyaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 629
SER A 348
LEU A 516
ILE A 353
 None
 0.96A 3ln1C-2x40A:
undetectable		 3ln1C-2x40A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		4 ARG F 671
SER F 475
ILE F 512
PHE F 503
 None
 1.09A 3ln1C-2xwbF:
undetectable		 3ln1C-2xwbF:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		4 SER A 359
LEU A  90
ARG A  59
ILE A 390
 None
None
KDM  A 500 (-2.7A)
None
 1.02A 3ln1C-2xziA:
undetectable		 3ln1C-2xziA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 GLN A 935
LEU A1104
ARG A1035
PHE A1034
 None
None
NA  A2156 (-4.0A)
None
 0.94A 3ln1C-2ya1A:
undetectable		 3ln1C-2ya1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLN A 480
LEU A 649
ARG A 580
PHE A 579
 None
 0.94A 3ln1C-2ya2A:
undetectable		 3ln1C-2ya2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 GLN A 144
LEU A 158
ARG A 146
PHE A 145
 None
 0.99A 3ln1C-2yikA:
undetectable		 3ln1C-2yikA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.87A 3ln1C-2z1uA:
undetectable		 3ln1C-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		4 ARG A  57
SER A  49
ILE A  47
PHE A 400
 None
 1.04A 3ln1C-2zbaA:
undetectable		 3ln1C-2zbaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		4 ARG A  32
LEU A  55
ARG A 127
ILE A 144
 None
None
DIO  A 991 (-3.2A)
None
 1.09A 3ln1C-3accA:
undetectable		 3ln1C-3accA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apu ALPHA-1-ACID
GLYCOPROTEIN 2

(Homo sapiens) 		PF00061
(Lipocalin) 		4 ARG A 152
GLN A   1
LEU A   8
ILE A   2
 None
 0.93A 3ln1C-3apuA:
undetectable		 3ln1C-3apuA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 ARG A 117
LEU A  14
ILE A  57
PHE A  35
 None
 1.03A 3ln1C-3b8lA:
undetectable		 3ln1C-3b8lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 SER A1122
ARG A1157
ILE A1167
PHE A1158
 None
 0.90A 3ln1C-3dm0A:
2.2		 3ln1C-3dm0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		4 ARG A1980
LEU A1832
ARG A1915
PHE A1914
 None
 0.95A 3ln1C-3edvA:
undetectable		 3ln1C-3edvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		4 SER A 419
LEU A 135
ILE A 426
PHE A 113
 None
 0.98A 3ln1C-3iiwA:
undetectable		 3ln1C-3iiwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		4 SER A 137
LEU A 205
ARG A 145
ILE A 188
 None
 1.07A 3ln1C-3ktnA:
undetectable		 3ln1C-3ktnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 ARG A  90
LEU A 253
ARG A 101
ILE A 105
 PAP  A 286 (-2.7A)
None
PAP  A 286 (-2.5A)
None
 1.00A 3ln1C-3mgbA:
undetectable		 3ln1C-3mgbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mso STEROID
DELTA-ISOMERASE

(Pseudomonas
aeruginosa) 		PF12680
(SnoaL_2) 		4 LEU A   6
ARG A 102
ILE A 109
PHE A 103
 None
 1.01A 3ln1C-3msoA:
undetectable		 3ln1C-3msoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ARG A 498
SER A 480
LEU A 468
ILE A 463
 None
 0.82A 3ln1C-3o6nA:
undetectable		 3ln1C-3o6nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 ARG B 498
SER B 480
LEU B 468
ILE B 463
 None
 0.83A 3ln1C-3ojaB:
undetectable		 3ln1C-3ojaB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		4 SER A 254
LEU A 231
ARG A 244
PHE A 243
 None
 1.09A 3ln1C-3pcoA:
undetectable		 3ln1C-3pcoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		4 ARG A1174
SER A1239
ARG A1233
PHE A1234
 None
 0.99A 3ln1C-3swhA:
undetectable		 3ln1C-3swhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cil YOPM-CAP, INTERNALIN
B

(Listeria
monocytogenes;
Yersinia
enterocolitica) 		PF08191
(LRR_adjacent)
PF12468
(TTSSLRR)
PF12799
(LRR_4) 		4 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 1.02A 3ln1C-4cilA:
undetectable		 3ln1C-4cilA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 SER A 167
LEU A 437
ILE A 192
PHE A 196
 None
 0.99A 3ln1C-4cp8A:
undetectable		 3ln1C-4cp8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 SER A 122
ARG A 155
ILE A 165
PHE A 156
 None
 0.87A 3ln1C-4d6vA:
undetectable		 3ln1C-4d6vA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 SER A 557
LEU A 582
ILE A 570
PHE A 592
 None
 0.97A 3ln1C-4db4A:
undetectable		 3ln1C-4db4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 SER A  68
LEU A 179
ILE A  31
PHE A  35
 None
 1.07A 3ln1C-4f2aA:
undetectable		 3ln1C-4f2aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7m ENDO-1,4-BETA-GLUCAN
ASE

(Trichoderma
harzianum) 		PF01670
(Glyco_hydro_12) 		4 ARG A 187
SER A  82
LEU A 124
ILE A 224
 None
 1.07A 3ln1C-4h7mA:
undetectable		 3ln1C-4h7mA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2o FIXK2 PROTEIN

(Bradyrhizobium
japonicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ARG A 170
LEU A 180
ILE A  82
PHE A  85
 None
 1.01A 3ln1C-4i2oA:
undetectable		 3ln1C-4i2oA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2k TRYPSIN INHIBITOR

(Enterolobium
contortisiliquum) 		PF00197
(Kunitz_legume) 		4 LEU A   3
ARG A 168
ILE A  19
PHE A 169
 None
GOL  A 202 (-3.7A)
None
None
 1.06A 3ln1C-4j2kA:
undetectable		 3ln1C-4j2kA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		4 ARG A 188
GLN A 238
ARG A 245
ILE A 237
 None
 1.05A 3ln1C-4j3cA:
undetectable		 3ln1C-4j3cA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 SER A 212
LEU A 196
ARG A 135
ILE A 209
 None
 1.01A 3ln1C-4k3fA:
undetectable		 3ln1C-4k3fA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		4 GLN A   9
SER A   4
LEU A  36
ILE A  11
 EDO  A 302 ( 3.7A)
EDO  A 302 (-2.4A)
None
None
 1.08A 3ln1C-4le7A:
undetectable		 3ln1C-4le7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 ARG A 101
LEU A 389
ILE A 421
PHE A 460
 None
 1.06A 3ln1C-4lglA:
2.6		 3ln1C-4lglA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		4 GLN A 112
LEU A 100
ARG A 107
ILE A 117
 SO4  A 713 (-4.0A)
None
SO4  A 709 (-3.1A)
None
 1.09A 3ln1C-4mtkA:
undetectable		 3ln1C-4mtkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		4 ARG A 226
SER A 193
LEU A 202
ILE A 119
 UNX  A1003 ( 4.0A)
SAH  A1001 (-2.7A)
None
None
 1.08A 3ln1C-4mtlA:
undetectable		 3ln1C-4mtlA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 ARG A 335
ARG A 304
ILE A 151
PHE A 303
 None
SO4  A 411 (-2.6A)
None
None
 1.08A 3ln1C-4o6mA:
1.8		 3ln1C-4o6mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiy PROTEIN TRANSPORT
PROTEIN SEC7

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 GLN A 916
SER A 913
LEU A1001
ILE A1010
 None
 1.02A 3ln1C-4oiyA:
undetectable		 3ln1C-4oiyA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 ARG A 121
GLN A 193
SER A 354
LEU A 385
ARG A 514
ILE A 518
PHE A 519
 BOG  A 604 ( 3.7A)
None
None
None
None
None
None
 0.42A 3ln1C-4ph9A:
63.8		 3ln1C-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 193
LEU A 508
ARG A 514
ILE A 518
PHE A 519
 None
 1.10A 3ln1C-4ph9A:
63.8		 3ln1C-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ARG A 617
SER A 585
LEU A 665
PHE A 590
 None
SO4  A2005 (-3.0A)
None
None
 1.01A 3ln1C-4q73A:
1.0		 3ln1C-4q73A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		4 GLN A  96
SER A  70
LEU A  12
ILE A  74
 None
 0.79A 3ln1C-4qfwA:
undetectable		 3ln1C-4qfwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 SER A 230
LEU A 258
ILE A 244
PHE A 245
 None
EDO  A 408 ( 4.0A)
None
None
 0.99A 3ln1C-4qtbA:
undetectable		 3ln1C-4qtbA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A 308
LEU A 412
ILE A 310
PHE A 368
 None
 1.07A 3ln1C-4udrA:
undetectable		 3ln1C-4udrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuk DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 SER B 437
LEU B 701
ILE B 464
PHE B 696
 None
 1.01A 3ln1C-4uukB:
undetectable		 3ln1C-4uukB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uv6 APICAL MEROZOITE
ANTIGEN 1

(Plasmodium
knowlesi) 		PF02430
(AMA-1) 		4 SER A 198
LEU A 121
ILE A 101
PHE A 126
 None
 0.99A 3ln1C-4uv6A:
undetectable		 3ln1C-4uv6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 ARG C 692
GLN C 581
SER C 622
ILE C 584
 None
 1.07A 3ln1C-4wsbC:
undetectable		 3ln1C-4wsbC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		4 ARG A 119
SER A 222
ARG A 302
ILE A 242
 None
 0.99A 3ln1C-4x9tA:
undetectable		 3ln1C-4x9tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 SER A 211
LEU A 239
ILE A 225
PHE A 226
 None
 1.09A 3ln1C-4xrlA:
undetectable		 3ln1C-4xrlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 231
LEU A  64
ARG A  95
ILE A  92
 None
 1.07A 3ln1C-4xvxA:
1.0		 3ln1C-4xvxA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 390
LEU A 425
ILE A 364
PHE A 392
 None
 0.98A 3ln1C-4z0cA:
undetectable		 3ln1C-4z0cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 GLN C 193
LEU C 145
ILE C 153
PHE C  90
 None
 1.04A 3ln1C-5a8rC:
undetectable		 3ln1C-5a8rC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1

(Homo sapiens) 		PF03587
(EMG1) 		4 SER A  91
LEU A  63
ILE A 126
PHE A 133
 None
 1.08A 3ln1C-5faiA:
undetectable		 3ln1C-5faiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 SER A 136
LEU A 263
ARG A 147
ILE A 146
 GWM  A 502 ( 2.5A)
None
HEM  A 501 ( 3.8A)
None
 1.07A 3ln1C-5gweA:
0.9		 3ln1C-5gweA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE

(Bacillus
thuringiensis) 		no annotation 4 ARG A 117
SER A  61
LEU A  81
ILE A  56
 None
 0.95A 3ln1C-5gwtA:
undetectable		 3ln1C-5gwtA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 GLN A 392
SER A  48
LEU A 207
ILE A 391
 None
 0.95A 3ln1C-5h42A:
undetectable		 3ln1C-5h42A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A 329
SER A 258
LEU A 361
ARG A 300
ILE A 298
 None
ANP  A 501 (-3.3A)
None
ANP  A 501 (-4.2A)
None
 1.41A 3ln1C-5htvA:
undetectable		 3ln1C-5htvA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 SER A  54
LEU A  77
ILE A  92
PHE A  86
 None
 1.05A 3ln1C-5husA:
undetectable		 3ln1C-5husA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 ARG A 120
GLN A 192
SER A 353
LEU A 384
ARG A 513
ILE A 517
PHE A 518
 ID8  A 601 ( 4.4A)
None
ID8  A 601 ( 4.7A)
ID8  A 601 ( 4.8A)
None
None
None
 0.35A 3ln1C-5ikrA:
62.5		 3ln1C-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 192
LEU A 507
ARG A 513
ILE A 517
PHE A 518
 None
 1.15A 3ln1C-5ikrA:
62.5		 3ln1C-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ARG B 635
SER B 746
LEU B 514
PHE A 813
 None
 0.82A 3ln1C-5ip9B:
undetectable		 3ln1C-5ip9B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 ARG A 562
LEU A 619
ARG A 703
ILE A 702
 None
 1.08A 3ln1C-5jz8A:
undetectable		 3ln1C-5jz8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 SER A 162
LEU A  94
ILE A 123
PHE A 133
 None
 1.04A 3ln1C-5m7rA:
undetectable		 3ln1C-5m7rA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 372
ARG A 378
ILE A 376
PHE A 377
 None
 1.06A 3ln1C-5mjsA:
undetectable		 3ln1C-5mjsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN

(Sulfolobus
solfataricus) 		no annotation 4 ARG B  84
SER B 185
LEU B  74
ARG B 192
 None
 1.10A 3ln1C-5ofnB:
undetectable		 3ln1C-5ofnB:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 ARG B 584
LEU B 316
ILE B 673
PHE B 615
 None
 1.07A 3ln1C-5swiB:
undetectable		 3ln1C-5swiB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN

(Vanderwaltozyma
polyspora) 		no annotation 4 SER A1020
LEU A1037
ARG A1025
ILE A1064
 None
 1.09A 3ln1C-5theA:
undetectable		 3ln1C-5theA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 318
SER A 310
ARG A 426
ILE A 392
 None
 0.92A 3ln1C-5uj1A:
undetectable		 3ln1C-5uj1A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3v GLOBIN

(Bacillus
anthracis) 		PF01152
(Bac_globin) 		4 ARG A 108
SER A  92
LEU A  54
PHE A  25
 None
 1.07A 3ln1C-5v3vA:
undetectable		 3ln1C-5v3vA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 SER A 162
LEU A  94
ILE A 123
PHE A 133
 None
 1.08A 3ln1C-5vvoA:
1.6		 3ln1C-5vvoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 ARG A 110
LEU A  97
ARG A  82
ILE A  84
 None
 1.07A 3ln1C-5x9gA:
undetectable		 3ln1C-5x9gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 LEU A 766
ARG A 758
ILE A 487
PHE A 488
 None
 0.89A 3ln1C-5xwyA:
undetectable		 3ln1C-5xwyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ARG A 575
LEU A 414
ILE A 644
PHE A 492
 None
 1.04A 3ln1C-6cgmA:
undetectable		 3ln1C-6cgmA:
8.39