SIMILAR PATTERNS OF AMINO ACIDS FOR 3LN1_C_CELC682

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A 152
VAL A  68
GLY A  70
ALA A  69
LEU A  90
 1BH  A 300 ( 3.7A)
None
None
None
None
 1.04A 3ln1C-1bh6A:
0.0		 3ln1C-1bh6A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A 152
VAL A  68
GLY A  70
ALA A  69
LEU A  90
 XE  A 281 ( 3.9A)
None
None
None
None
 1.04A 3ln1C-1c3lA:
undetectable		 3ln1C-1c3lA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 HIS A  57
VAL A  91
LEU A  95
GLY A  49
LEU A  78
 None
None
None
NAP  A 386 (-3.2A)
None
 1.07A 3ln1C-1civA:
0.0		 3ln1C-1civA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 HIS A  90
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.32A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2e GLUTATHIONE
S-TRANSFERASE

(Sphingomonas
paucimobilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  12
TYR A 181
ALA A 166
GLY A 183
ALA A 186
 None
 0.96A 3ln1C-1f2eA:
0.0		 3ln1C-1f2eA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 LEU A 185
ALA B 422
VAL B 409
GLY B 356
SER A 188
 None
 1.05A 3ln1C-1gxsA:
0.0		 3ln1C-1gxsA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.07A 3ln1C-1i8dA:
undetectable		 3ln1C-1i8dA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		5 HIS A  56
TYR A 237
ALA A  54
GLY A 257
ALA A 256
 None
 0.96A 3ln1C-1j33A:
0.0		 3ln1C-1j33A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 182
ALA A 167
VAL A 235
GLY A  10
ALA A  82
 None
 0.96A 3ln1C-1j3nA:
undetectable		 3ln1C-1j3nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 237
LEU A 182
ALA A 167
ALA A  79
LEU A  83
 None
 1.00A 3ln1C-1j3nA:
undetectable		 3ln1C-1j3nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.01A 3ln1C-1jioA:
1.7		 3ln1C-1jioA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.98A 3ln1C-1jy1A:
undetectable		 3ln1C-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.01A 3ln1C-1n61C:
2.0		 3ln1C-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.93A 3ln1C-1nvtA:
undetectable		 3ln1C-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		5 VAL A 183
LEU A 148
ALA A 132
GLY A 202
ALA A 201
 None
 1.00A 3ln1C-1p0nA:
undetectable		 3ln1C-1p0nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 HIS A 125
LEU A 278
ALA A  56
ALA A  82
LEU A  50
 NAP  A 500 ( 4.8A)
NAP  A 500 (-4.0A)
None
None
None
 1.07A 3ln1C-1pz1A:
undetectable		 3ln1C-1pz1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178

(Aquifex
aeolicus) 		PF00582
(Usp) 		5 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.99A 3ln1C-1q77A:
undetectable		 3ln1C-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 VAL A  46
ALA A  38
VAL A  14
GLY A  17
LEU A 219
 VAL  A  46 ( 0.6A)
ALA  A  38 ( 0.0A)
VAL  A  14 ( 0.6A)
GLY  A  17 ( 0.0A)
LEU  A 219 ( 0.6A)
 0.95A 3ln1C-1rrvA:
undetectable		 3ln1C-1rrvA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
 None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
 1.05A 3ln1C-1sezA:
undetectable		 3ln1C-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 1.04A 3ln1C-1uaaA:
2.0		 3ln1C-1uaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.03A 3ln1C-2aizP:
undetectable		 3ln1C-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 1.03A 3ln1C-2cb1A:
undetectable		 3ln1C-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 196
LEU A 189
ALA A  90
GLY A 213
ALA A 214
 None
 0.97A 3ln1C-2cb1A:
undetectable		 3ln1C-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 LEU A 293
TYR A 113
ALA A 102
VAL A 118
GLY A 117
 None
 1.05A 3ln1C-2cevA:
undetectable		 3ln1C-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 LEU A 381
ALA A  35
VAL A  16
GLY A   6
ALA A   5
 None
 1.01A 3ln1C-2d0oA:
undetectable		 3ln1C-2d0oA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
 PMS  A 601 ( 3.8A)
None
None
None
None
 0.96A 3ln1C-2gkoA:
undetectable		 3ln1C-2gkoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 0.99A 3ln1C-2hfsA:
undetectable		 3ln1C-2hfsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4k GENERAL STRESS
PROTEIN 13

(Bacillus
subtilis) 		PF00575
(S1) 		5 ALA A  78
VAL A  35
GLY A  22
ALA A  23
LEU A  18
 None
 0.96A 3ln1C-2k4kA:
undetectable		 3ln1C-2k4kA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzc HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		no annotation 5 LEU A  51
VAL A  73
GLY A  68
SER A  64
LEU A  63
 None
 0.98A 3ln1C-2nzcA:
undetectable		 3ln1C-2nzcA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.07A 3ln1C-2o5rA:
undetectable		 3ln1C-2o5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
vanbaalenii) 		PF00440
(TetR_N) 		5 VAL A  47
LEU A  57
ALA A  10
GLY A  41
ALA A  40
 None
 0.91A 3ln1C-2qwtA:
2.0		 3ln1C-2qwtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.92A 3ln1C-2wjvA:
undetectable		 3ln1C-2wjvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 LEU A  79
ALA A 148
VAL A  70
GLY A  72
ALA A  75
 None
 1.05A 3ln1C-2wsxA:
undetectable		 3ln1C-2wsxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ALA A 223
VAL A 235
GLY A 238
ALA A 241
LEU A 244
 None
 1.04A 3ln1C-2xgtA:
undetectable		 3ln1C-2xgtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 VAL A 108
ALA A 438
GLY A 160
ALA A 159
SER A 156
 None
 0.94A 3ln1C-2y2wA:
undetectable		 3ln1C-2y2wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.92A 3ln1C-2yr5A:
undetectable		 3ln1C-2yr5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 567
ALA A 533
ALA A 549
SER A 551
LEU A 552
 None
 0.86A 3ln1C-3b9pA:
undetectable		 3ln1C-3b9pA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhq TRANSCRIPTIONAL
REGULATOR

(Mesorhizobium
japonicum) 		PF00440
(TetR_N)
PF14246
(TetR_C_7) 		5 VAL A  48
LEU A  58
ALA A  10
GLY A  42
ALA A  41
 None
 1.03A 3ln1C-3bhqA:
undetectable		 3ln1C-3bhqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.04A 3ln1C-3d43A:
undetectable		 3ln1C-3d43A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacteroides
thetaiotaomicron) 		PF13460
(NAD_binding_10) 		5 VAL A  31
LEU A  25
VAL A  35
GLY A  11
ALA A  12
 None
 1.04A 3ln1C-3dhnA:
undetectable		 3ln1C-3dhnA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 5 ALA A2023
VAL A2062
ALA A2066
SER A2068
LEU A2069
 None
 0.85A 3ln1C-3dyjA:
undetectable		 3ln1C-3dyjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 380
VAL A 267
ALA A 271
SER A 274
LEU A 275
 None
 1.06A 3ln1C-3e1hA:
undetectable		 3ln1C-3e1hA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 380
VAL A 267
ALA A 271
SER A 274
LEU A 275
 None
 1.08A 3ln1C-3euoA:
undetectable		 3ln1C-3euoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		5 VAL A 236
LEU A 225
ALA A 110
GLY A 205
ALA A 206
 None
 1.03A 3ln1C-3f7wA:
undetectable		 3ln1C-3f7wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 5 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 0.99A 3ln1C-3fyqA:
undetectable		 3ln1C-3fyqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 457
ALA A 495
VAL A 113
GLY A 112
ALA A 111
 HBX  A 530 (-4.3A)
None
FAD  A 522 (-3.7A)
FAD  A 522 (-3.9A)
FAD  A 522 ( 3.0A)
 0.92A 3ln1C-3gdnA:
undetectable		 3ln1C-3gdnA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.90A 3ln1C-3h6eA:
undetectable		 3ln1C-3h6eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.03A 3ln1C-3iwaA:
undetectable		 3ln1C-3iwaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 LEU A 398
ALA A 193
ALA A 165
SER A 168
LEU A 169
 None
 0.86A 3ln1C-3j1eA:
1.5		 3ln1C-3j1eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 108
LEU A 112
GLY A  76
SER A  79
LEU A  80
 None
None
AKG  A 224 (-3.1A)
None
None
 1.05A 3ln1C-3la2A:
undetectable		 3ln1C-3la2A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 155
LEU A 163
ALA A 171
GLY A 214
ALA A 215
 None
 0.91A 3ln1C-3mi9A:
undetectable		 3ln1C-3mi9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		6 VAL A 518
ALA A 627
GLY A 543
ALA A 546
SER A 545
LEU A 549
 None
 1.37A 3ln1C-3o4zA:
undetectable		 3ln1C-3o4zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 VAL A 310
LEU A 314
ALA A 295
GLY A 268
ALA A 269
 None
 1.07A 3ln1C-3pl2A:
undetectable		 3ln1C-3pl2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 458
ALA A 496
VAL A 113
GLY A 112
ALA A 111
 None
None
FAD  A 773 (-3.7A)
FAD  A 773 (-3.9A)
FAD  A 773 (-3.0A)
 0.96A 3ln1C-3redA:
undetectable		 3ln1C-3redA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.01A 3ln1C-3tfyA:
undetectable		 3ln1C-3tfyA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
 None
 1.04A 3ln1C-3uw2A:
undetectable		 3ln1C-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.02A 3ln1C-4b4uA:
undetectable		 3ln1C-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 TYR A 247
GLY A 216
ALA A 218
SER A 220
LEU A 221
 None
KCX  A 219 ( 4.5A)
KCX  A 219 ( 3.1A)
KCX  A 219 ( 4.3A)
None
 1.00A 3ln1C-4c13A:
undetectable		 3ln1C-4c13A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		5 VAL A 258
LEU A 300
VAL A 238
GLY A 241
LEU A 288
 None
 1.06A 3ln1C-4d2jA:
undetectable		 3ln1C-4d2jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 VAL B 176
ALA B 359
GLY B 274
ALA B 273
SER B  54
 None
 1.04A 3ln1C-4iu9B:
1.3		 3ln1C-4iu9B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.76A 3ln1C-4j9uA:
2.2		 3ln1C-4j9uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 TYR A 165
LEU A 245
ALA A 131
GLY A 276
ALA A 275
 None
None
NAP  A 402 ( 3.3A)
None
None
 1.04A 3ln1C-4jb1A:
undetectable		 3ln1C-4jb1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		5 VAL A 178
ALA A 362
GLY A 276
ALA A 275
SER A  56
 None
 0.91A 3ln1C-4jreA:
2.4		 3ln1C-4jreA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.92A 3ln1C-4k3jA:
undetectable		 3ln1C-4k3jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		5 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.06A 3ln1C-4kl0A:
undetectable		 3ln1C-4kl0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.83A 3ln1C-4mfzA:
undetectable		 3ln1C-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nng 30S RIBOSOMAL
PROTEIN S1

(Mycobacterium
tuberculosis) 		PF00575
(S1) 		5 ALA A 365
VAL A 321
GLY A 308
ALA A 309
LEU A 304
 None
 1.05A 3ln1C-4nngA:
undetectable		 3ln1C-4nngA:
15.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 HIS A  90
VAL A 350
TYR A 356
LEU A 360
TYR A 386
TRP A 388
ALA A 517
VAL A 524
GLY A 527
ALA A 528
SER A 531
LEU A 532
 None
IBP  A 601 (-4.3A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.52A 3ln1C-4ph9A:
63.8		 3ln1C-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 VAL A1006
LEU A 524
VAL A 967
GLY A 969
ALA A 968
 None
 0.95A 3ln1C-4pj6A:
2.3		 3ln1C-4pj6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 TYR A 209
LEU A 204
ALA A 216
GLY A 234
SER A 236
 None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
COA  A 403 (-3.1A)
 0.98A 3ln1C-4q38A:
undetectable		 3ln1C-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 VAL A 197
TYR A 209
LEU A 204
ALA A 216
GLY A 234
 TEC  A 404 ( 4.2A)
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
 0.89A 3ln1C-4q38A:
undetectable		 3ln1C-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		5 HIS A 258
LEU A 318
VAL A 327
GLY A 337
SER A 335
 None
 1.01A 3ln1C-4q8kA:
undetectable		 3ln1C-4q8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		5 HIS A  91
LEU A 151
VAL A 160
GLY A 170
SER A 168
 None
 0.96A 3ln1C-4q8lA:
undetectable		 3ln1C-4q8lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 HIS A 279
TYR A 423
ALA A 262
GLY A 286
SER A 329
 None
 1.01A 3ln1C-4r1dA:
undetectable		 3ln1C-4r1dA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 LEU A 209
ALA A  95
VAL A  82
GLY A  80
ALA A  79
 None
 1.05A 3ln1C-4rncA:
undetectable		 3ln1C-4rncA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		5 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.93A 3ln1C-4us5A:
undetectable		 3ln1C-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.00A 3ln1C-4z19A:
undetectable		 3ln1C-4z19A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.74A 3ln1C-4zqbA:
undetectable		 3ln1C-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.05A 3ln1C-5a4jA:
undetectable		 3ln1C-5a4jA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE

(Rhizomucor
miehei) 		PF00291
(PALP) 		5 VAL A 258
GLY A 283
ALA A 285
SER A 287
LEU A 288
 None
 1.08A 3ln1C-5c3uA:
undetectable		 3ln1C-5c3uA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbn ACETATE
COA-TRANSFERASE
SUBUNIT BETA

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 VAL B  21
LEU B  43
VAL B  11
ALA B  12
LEU B  35
 None
 1.05A 3ln1C-5dbnB:
undetectable		 3ln1C-5dbnB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.95A 3ln1C-5dotA:
undetectable		 3ln1C-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dus ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		5 VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
 None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
 0.92A 3ln1C-5dusA:
undetectable		 3ln1C-5dusA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exx TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		5 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.02A 3ln1C-5exxA:
undetectable		 3ln1C-5exxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.05A 3ln1C-5f4zA:
undetectable		 3ln1C-5f4zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A 158
VAL A  72
GLY A  74
ALA A  73
LEU A  91
 None
None
5VV  A   1 ( 4.8A)
None
None
 0.94A 3ln1C-5fbzA:
undetectable		 3ln1C-5fbzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A 265
VAL A  76
GLY A  74
ALA A  73
LEU A  33
 None
None
5VV  A   1 ( 4.8A)
None
None
 1.08A 3ln1C-5fbzA:
undetectable		 3ln1C-5fbzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 ALA A 167
VAL A  76
GLY A  78
ALA A  77
LEU A 100
 None
 1.01A 3ln1C-5ffnA:
undetectable		 3ln1C-5ffnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii) 		PF08541
(ACP_syn_III_C) 		5 VAL A 149
LEU A  90
ALA A 341
GLY A  76
LEU A  84
 None
 1.00A 3ln1C-5gk2A:
undetectable		 3ln1C-5gk2A:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 HIS A  90
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.33A 3ln1C-5ikrA:
62.5		 3ln1C-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 0.89A 3ln1C-5ohsA:
undetectable		 3ln1C-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr3 DIHYDROLIPOYL
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 144
VAL A   9
GLY A  11
ALA A 150
SER A 151
 None
None
FAD  A 501 (-3.4A)
None
FAD  A 501 (-4.6A)
 1.08A 3ln1C-5tr3A:
3.0		 3ln1C-5tr3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		5 HIS A1714
VAL A1655
LEU A1690
ALA A1718
GLY A1531
 None
 1.08A 3ln1C-5v41A:
undetectable		 3ln1C-5v41A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 5 VAL A 434
LEU A 303
VAL A 463
GLY A 476
ALA A 477
 None
 1.08A 3ln1C-5xilA:
undetectable		 3ln1C-5xilA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.07A 3ln1C-5y09A:
undetectable		 3ln1C-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 5 ALA A  70
GLY A 192
ALA A 191
SER A 190
LEU A 248
 None
LLP  A  63 ( 3.3A)
LLP  A  63 ( 3.5A)
LLP  A  63 ( 4.2A)
None
 1.01A 3ln1C-5ybwA:
undetectable		 3ln1C-5ybwA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ALA A 160
VAL A  77
GLY A  80
ALA A  81
LEU A  85
 None
 0.69A 3ln1C-5yvsA:
undetectable		 3ln1C-5yvsA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 5 VAL A 160
ALA A 520
GLY A 559
ALA A 560
SER A 156
 None
GOL  A 701 (-3.4A)
None
None
None
 0.90A 3ln1C-5zl9A:
undetectable		 3ln1C-5zl9A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A 186
LEU A 187
VAL A 239
ALA A 243
LEU A 247
 None
None
None
None
CLR  A1202 ( 4.3A)
 1.02A 3ln1C-6aqfA:
undetectable		 3ln1C-6aqfA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 5 LEU A  26
ALA A 118
GLY A 179
ALA A 262
SER A 264
 None
COA  A 301 (-3.3A)
None
None
None
 1.04A 3ln1C-6bc5A:
undetectable		 3ln1C-6bc5A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		4 GLN A  96
SER A  70
LEU A  12
ILE A  74
 None
 0.88A 3ln1C-1c8uA:
0.0		 3ln1C-1c8uA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 0.98A 3ln1C-1d0bA:
undetectable		 3ln1C-1d0bA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ARG A 120
GLN A 192
SER A 353
LEU A 384
ILE A 517
 SCL  A 700 (-3.9A)
None
None
None
None
 0.44A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 192
SER A 353
LEU A 384
ILE A 517
PHE A 518
 None
 0.79A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 192
SER A 353
LEU A 507
ILE A 517
PHE A 518
 None
 1.21A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		5 GLN A 420
SER A 190
LEU A 552
ARG A 416
ILE A 414
 None
 1.47A 3ln1C-1fokA:
0.0		 3ln1C-1fokA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 SER A 156
LEU A 223
ILE A 160
PHE A 161
 None
 1.04A 3ln1C-1jd0A:
undetectable		 3ln1C-1jd0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		4 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 1.09A 3ln1C-1m9sA:
undetectable		 3ln1C-1m9sA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 SER A   7
LEU A  57
ILE A 175
PHE A   9
 None
 1.01A 3ln1C-1mozA:
0.0		 3ln1C-1mozA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 GLN A 227
SER A 195
LEU A 241
ILE A 230
 None
 0.97A 3ln1C-1oypA:
0.0		 3ln1C-1oypA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		4 SER A 635
LEU A 585
ARG A 641
PHE A 544
 None
 1.07A 3ln1C-1t6pA:
0.0		 3ln1C-1t6pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tke THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF02824
(TGS)
PF07973
(tRNA_SAD) 		4 SER A 154
LEU A 172
ARG A 145
ILE A 159
 None
 1.06A 3ln1C-1tkeA:
0.0		 3ln1C-1tkeA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 SER A1180
LEU A 998
ARG A1257
ILE A1177
 None
 1.03A 3ln1C-1tllA:
undetectable		 3ln1C-1tllA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux8 YJBI PROTEIN

(Bacillus
subtilis) 		PF01152
(Bac_globin) 		4 ARG A 107
SER A  91
LEU A  53
PHE A  24
 None
None
HEM  A 700 (-4.9A)
None
 1.06A 3ln1C-1ux8A:
undetectable		 3ln1C-1ux8A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A 404
GLN A 529
LEU A 507
ILE A  32
 None
 1.08A 3ln1C-1w6sA:
undetectable		 3ln1C-1w6sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 SER A 148
LEU A 204
ARG A 158
ILE A 153
PHE A 157
 None
 1.33A 3ln1C-1x8vA:
2.0		 3ln1C-1x8vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 407
LEU A 159
ARG A 119
ILE A 445
 None
None
ABW  A1000 (-3.2A)
None
 1.06A 3ln1C-1xogA:
undetectable		 3ln1C-1xogA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7v TRANSMEMBRANE
PROTEASE

(Mus musculus) 		PF01390
(SEA) 		4 ARG A 121
ARG A  89
ILE A  84
PHE A  88
 None
 1.05A 3ln1C-2e7vA:
undetectable		 3ln1C-2e7vA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS 3

(Rattus
norvegicus) 		PF00536
(SAM_1) 		4 LEU A  19
ARG A  25
ILE A  31
PHE A  26
 None
 1.01A 3ln1C-2f3nA:
undetectable		 3ln1C-2f3nA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF13638
(PIN_4) 		4 LEU A1266
ARG A1321
ILE A1338
PHE A1318
 None
 0.99A 3ln1C-2hwxA:
undetectable		 3ln1C-2hwxA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 SER A 151
LEU A 242
ARG A 153
ILE A 204
 None
 1.06A 3ln1C-2jgpA:
undetectable		 3ln1C-2jgpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		4 SER A  36
LEU A   7
ARG A 330
ILE A 328
 None
 1.04A 3ln1C-2pn1A:
undetectable		 3ln1C-2pn1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt5 SHIKIMATE KINASE

(Aquifex
aeolicus) 		PF01202
(SKI) 		4 ARG A  22
SER A  14
LEU A 158
ILE A  99
 None
 0.92A 3ln1C-2pt5A:
undetectable		 3ln1C-2pt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3s PROTEIN AT5G06450

(Arabidopsis
thaliana) 		no annotation 4 SER A 106
LEU A  87
ILE A 131
PHE A 104
 None
 0.99A 3ln1C-2q3sA:
undetectable		 3ln1C-2q3sA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 GLN A  93
LEU A  48
ILE A  84
PHE A  64
 None
 1.04A 3ln1C-2q9sA:
undetectable		 3ln1C-2q9sA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 ARG A 255
LEU A 267
ILE A  18
PHE A 272
 None
 1.04A 3ln1C-2r98A:
undetectable		 3ln1C-2r98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 510
ARG B 581
ILE B 506
PHE B 582
 None
 0.99A 3ln1C-2w55B:
undetectable		 3ln1C-2w55B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 SER A 272
LEU A 292
ILE A 277
PHE A 290
 None
 0.95A 3ln1C-2wyaA:
undetectable		 3ln1C-2wyaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 629
SER A 348
LEU A 516
ILE A 353
 None
 0.96A 3ln1C-2x40A:
undetectable		 3ln1C-2x40A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		4 ARG F 671
SER F 475
ILE F 512
PHE F 503
 None
 1.09A 3ln1C-2xwbF:
undetectable		 3ln1C-2xwbF:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		4 SER A 359
LEU A  90
ARG A  59
ILE A 390
 None
None
KDM  A 500 (-2.7A)
None
 1.02A 3ln1C-2xziA:
undetectable		 3ln1C-2xziA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 GLN A 935
LEU A1104
ARG A1035
PHE A1034
 None
None
NA  A2156 (-4.0A)
None
 0.94A 3ln1C-2ya1A:
undetectable		 3ln1C-2ya1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLN A 480
LEU A 649
ARG A 580
PHE A 579
 None
 0.94A 3ln1C-2ya2A:
undetectable		 3ln1C-2ya2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 GLN A 144
LEU A 158
ARG A 146
PHE A 145
 None
 0.99A 3ln1C-2yikA:
undetectable		 3ln1C-2yikA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.87A 3ln1C-2z1uA:
undetectable		 3ln1C-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		4 ARG A  57
SER A  49
ILE A  47
PHE A 400
 None
 1.04A 3ln1C-2zbaA:
undetectable		 3ln1C-2zbaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		4 ARG A  32
LEU A  55
ARG A 127
ILE A 144
 None
None
DIO  A 991 (-3.2A)
None
 1.09A 3ln1C-3accA:
undetectable		 3ln1C-3accA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apu ALPHA-1-ACID
GLYCOPROTEIN 2

(Homo sapiens) 		PF00061
(Lipocalin) 		4 ARG A 152
GLN A   1
LEU A   8
ILE A   2
 None
 0.93A 3ln1C-3apuA:
undetectable		 3ln1C-3apuA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 ARG A 117
LEU A  14
ILE A  57
PHE A  35
 None
 1.03A 3ln1C-3b8lA:
undetectable		 3ln1C-3b8lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 SER A1122
ARG A1157
ILE A1167
PHE A1158
 None
 0.90A 3ln1C-3dm0A:
2.2		 3ln1C-3dm0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		4 ARG A1980
LEU A1832
ARG A1915
PHE A1914
 None
 0.95A 3ln1C-3edvA:
undetectable		 3ln1C-3edvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		4 SER A 419
LEU A 135
ILE A 426
PHE A 113
 None
 0.98A 3ln1C-3iiwA:
undetectable		 3ln1C-3iiwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		4 SER A 137
LEU A 205
ARG A 145
ILE A 188
 None
 1.07A 3ln1C-3ktnA:
undetectable		 3ln1C-3ktnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 ARG A  90
LEU A 253
ARG A 101
ILE A 105
 PAP  A 286 (-2.7A)
None
PAP  A 286 (-2.5A)
None
 1.00A 3ln1C-3mgbA:
undetectable		 3ln1C-3mgbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mso STEROID
DELTA-ISOMERASE

(Pseudomonas
aeruginosa) 		PF12680
(SnoaL_2) 		4 LEU A   6
ARG A 102
ILE A 109
PHE A 103
 None
 1.01A 3ln1C-3msoA:
undetectable		 3ln1C-3msoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ARG A 498
SER A 480
LEU A 468
ILE A 463
 None
 0.82A 3ln1C-3o6nA:
undetectable		 3ln1C-3o6nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 ARG B 498
SER B 480
LEU B 468
ILE B 463
 None
 0.83A 3ln1C-3ojaB:
undetectable		 3ln1C-3ojaB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		4 SER A 254
LEU A 231
ARG A 244
PHE A 243
 None
 1.09A 3ln1C-3pcoA:
undetectable		 3ln1C-3pcoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		4 ARG A1174
SER A1239
ARG A1233
PHE A1234
 None
 0.99A 3ln1C-3swhA:
undetectable		 3ln1C-3swhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cil YOPM-CAP, INTERNALIN
B

(Listeria
monocytogenes;
Yersinia
enterocolitica) 		PF08191
(LRR_adjacent)
PF12468
(TTSSLRR)
PF12799
(LRR_4) 		4 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 1.02A 3ln1C-4cilA:
undetectable		 3ln1C-4cilA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 SER A 167
LEU A 437
ILE A 192
PHE A 196
 None
 0.99A 3ln1C-4cp8A:
undetectable		 3ln1C-4cp8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		4 SER A 122
ARG A 155
ILE A 165
PHE A 156
 None
 0.87A 3ln1C-4d6vA:
undetectable		 3ln1C-4d6vA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 SER A 557
LEU A 582
ILE A 570
PHE A 592
 None
 0.97A 3ln1C-4db4A:
undetectable		 3ln1C-4db4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 SER A  68
LEU A 179
ILE A  31
PHE A  35
 None
 1.07A 3ln1C-4f2aA:
undetectable		 3ln1C-4f2aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7m ENDO-1,4-BETA-GLUCAN
ASE

(Trichoderma
harzianum) 		PF01670
(Glyco_hydro_12) 		4 ARG A 187
SER A  82
LEU A 124
ILE A 224
 None
 1.07A 3ln1C-4h7mA:
undetectable		 3ln1C-4h7mA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2o FIXK2 PROTEIN

(Bradyrhizobium
japonicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ARG A 170
LEU A 180
ILE A  82
PHE A  85
 None
 1.01A 3ln1C-4i2oA:
undetectable		 3ln1C-4i2oA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2k TRYPSIN INHIBITOR

(Enterolobium
contortisiliquum) 		PF00197
(Kunitz_legume) 		4 LEU A   3
ARG A 168
ILE A  19
PHE A 169
 None
GOL  A 202 (-3.7A)
None
None
 1.06A 3ln1C-4j2kA:
undetectable		 3ln1C-4j2kA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		4 ARG A 188
GLN A 238
ARG A 245
ILE A 237
 None
 1.05A 3ln1C-4j3cA:
undetectable		 3ln1C-4j3cA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 SER A 212
LEU A 196
ARG A 135
ILE A 209
 None
 1.01A 3ln1C-4k3fA:
undetectable		 3ln1C-4k3fA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		4 GLN A   9
SER A   4
LEU A  36
ILE A  11
 EDO  A 302 ( 3.7A)
EDO  A 302 (-2.4A)
None
None
 1.08A 3ln1C-4le7A:
undetectable		 3ln1C-4le7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 ARG A 101
LEU A 389
ILE A 421
PHE A 460
 None
 1.06A 3ln1C-4lglA:
2.6		 3ln1C-4lglA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		4 GLN A 112
LEU A 100
ARG A 107
ILE A 117
 SO4  A 713 (-4.0A)
None
SO4  A 709 (-3.1A)
None
 1.09A 3ln1C-4mtkA:
undetectable		 3ln1C-4mtkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C

(Homo sapiens) 		PF10294
(Methyltransf_16) 		4 ARG A 226
SER A 193
LEU A 202
ILE A 119
 UNX  A1003 ( 4.0A)
SAH  A1001 (-2.7A)
None
None
 1.08A 3ln1C-4mtlA:
undetectable		 3ln1C-4mtlA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 ARG A 335
ARG A 304
ILE A 151
PHE A 303
 None
SO4  A 411 (-2.6A)
None
None
 1.08A 3ln1C-4o6mA:
1.8		 3ln1C-4o6mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiy PROTEIN TRANSPORT
PROTEIN SEC7

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 GLN A 916
SER A 913
LEU A1001
ILE A1010
 None
 1.02A 3ln1C-4oiyA:
undetectable		 3ln1C-4oiyA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 ARG A 121
GLN A 193
SER A 354
LEU A 385
ARG A 514
ILE A 518
PHE A 519
 BOG  A 604 ( 3.7A)
None
None
None
None
None
None
 0.42A 3ln1C-4ph9A:
63.8		 3ln1C-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 193
LEU A 508
ARG A 514
ILE A 518
PHE A 519
 None
 1.10A 3ln1C-4ph9A:
63.8		 3ln1C-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ARG A 617
SER A 585
LEU A 665
PHE A 590
 None
SO4  A2005 (-3.0A)
None
None
 1.01A 3ln1C-4q73A:
1.0		 3ln1C-4q73A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II

(Yersinia pestis) 		PF13622
(4HBT_3) 		4 GLN A  96
SER A  70
LEU A  12
ILE A  74
 None
 0.79A 3ln1C-4qfwA:
undetectable		 3ln1C-4qfwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 SER A 230
LEU A 258
ILE A 244
PHE A 245
 None
EDO  A 408 ( 4.0A)
None
None
 0.99A 3ln1C-4qtbA:
undetectable		 3ln1C-4qtbA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A 308
LEU A 412
ILE A 310
PHE A 368
 None
 1.07A 3ln1C-4udrA:
undetectable		 3ln1C-4udrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuk DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 SER B 437
LEU B 701
ILE B 464
PHE B 696
 None
 1.01A 3ln1C-4uukB:
undetectable		 3ln1C-4uukB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uv6 APICAL MEROZOITE
ANTIGEN 1

(Plasmodium
knowlesi) 		PF02430
(AMA-1) 		4 SER A 198
LEU A 121
ILE A 101
PHE A 126
 None
 0.99A 3ln1C-4uv6A:
undetectable		 3ln1C-4uv6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 ARG C 692
GLN C 581
SER C 622
ILE C 584
 None
 1.07A 3ln1C-4wsbC:
undetectable		 3ln1C-4wsbC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		4 ARG A 119
SER A 222
ARG A 302
ILE A 242
 None
 0.99A 3ln1C-4x9tA:
undetectable		 3ln1C-4x9tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 SER A 211
LEU A 239
ILE A 225
PHE A 226
 None
 1.09A 3ln1C-4xrlA:
undetectable		 3ln1C-4xrlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 231
LEU A  64
ARG A  95
ILE A  92
 None
 1.07A 3ln1C-4xvxA:
1.0		 3ln1C-4xvxA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 390
LEU A 425
ILE A 364
PHE A 392
 None
 0.98A 3ln1C-4z0cA:
undetectable		 3ln1C-4z0cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 GLN C 193
LEU C 145
ILE C 153
PHE C  90
 None
 1.04A 3ln1C-5a8rC:
undetectable		 3ln1C-5a8rC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1

(Homo sapiens) 		PF03587
(EMG1) 		4 SER A  91
LEU A  63
ILE A 126
PHE A 133
 None
 1.08A 3ln1C-5faiA:
undetectable		 3ln1C-5faiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 SER A 136
LEU A 263
ARG A 147
ILE A 146
 GWM  A 502 ( 2.5A)
None
HEM  A 501 ( 3.8A)
None
 1.07A 3ln1C-5gweA:
0.9		 3ln1C-5gweA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE

(Bacillus
thuringiensis) 		no annotation 4 ARG A 117
SER A  61
LEU A  81
ILE A  56
 None
 0.95A 3ln1C-5gwtA:
undetectable		 3ln1C-5gwtA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 GLN A 392
SER A  48
LEU A 207
ILE A 391
 None
 0.95A 3ln1C-5h42A:
undetectable		 3ln1C-5h42A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLN A 329
SER A 258
LEU A 361
ARG A 300
ILE A 298
 None
ANP  A 501 (-3.3A)
None
ANP  A 501 (-4.2A)
None
 1.41A 3ln1C-5htvA:
undetectable		 3ln1C-5htvA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		4 SER A  54
LEU A  77
ILE A  92
PHE A  86
 None
 1.05A 3ln1C-5husA:
undetectable		 3ln1C-5husA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 ARG A 120
GLN A 192
SER A 353
LEU A 384
ARG A 513
ILE A 517
PHE A 518
 ID8  A 601 ( 4.4A)
None
ID8  A 601 ( 4.7A)
ID8  A 601 ( 4.8A)
None
None
None
 0.35A 3ln1C-5ikrA:
62.5		 3ln1C-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 GLN A 192
LEU A 507
ARG A 513
ILE A 517
PHE A 518
 None
 1.15A 3ln1C-5ikrA:
62.5		 3ln1C-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ARG B 635
SER B 746
LEU B 514
PHE A 813
 None
 0.82A 3ln1C-5ip9B:
undetectable		 3ln1C-5ip9B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 ARG A 562
LEU A 619
ARG A 703
ILE A 702
 None
 1.08A 3ln1C-5jz8A:
undetectable		 3ln1C-5jz8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 SER A 162
LEU A  94
ILE A 123
PHE A 133
 None
 1.04A 3ln1C-5m7rA:
undetectable		 3ln1C-5m7rA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 372
ARG A 378
ILE A 376
PHE A 377
 None
 1.06A 3ln1C-5mjsA:
undetectable		 3ln1C-5mjsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN

(Sulfolobus
solfataricus) 		no annotation 4 ARG B  84
SER B 185
LEU B  74
ARG B 192
 None
 1.10A 3ln1C-5ofnB:
undetectable		 3ln1C-5ofnB:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 ARG B 584
LEU B 316
ILE B 673
PHE B 615
 None
 1.07A 3ln1C-5swiB:
undetectable		 3ln1C-5swiB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN

(Vanderwaltozyma
polyspora) 		no annotation 4 SER A1020
LEU A1037
ARG A1025
ILE A1064
 None
 1.09A 3ln1C-5theA:
undetectable		 3ln1C-5theA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 318
SER A 310
ARG A 426
ILE A 392
 None
 0.92A 3ln1C-5uj1A:
undetectable		 3ln1C-5uj1A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3v GLOBIN

(Bacillus
anthracis) 		PF01152
(Bac_globin) 		4 ARG A 108
SER A  92
LEU A  54
PHE A  25
 None
 1.07A 3ln1C-5v3vA:
undetectable		 3ln1C-5v3vA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 SER A 162
LEU A  94
ILE A 123
PHE A 133
 None
 1.08A 3ln1C-5vvoA:
1.6		 3ln1C-5vvoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 ARG A 110
LEU A  97
ARG A  82
ILE A  84
 None
 1.07A 3ln1C-5x9gA:
undetectable		 3ln1C-5x9gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 LEU A 766
ARG A 758
ILE A 487
PHE A 488
 None
 0.89A 3ln1C-5xwyA:
undetectable		 3ln1C-5xwyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ARG A 575
LEU A 414
ILE A 644
PHE A 492
 None
 1.04A 3ln1C-6cgmA:
undetectable		 3ln1C-6cgmA:
8.39