SIMILAR PATTERNS OF AMINO ACIDS FOR 3LN1_A_CELA682_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5f | MONOCLONALANTI-E-SELECTIN 7A9ANTIBODY (HEAVYCHAIN) (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | LEU H 86SER H 85LEU H 81TYR H 94 | None | 0.88A | 3ln1A-1a5fH:0.0 | 3ln1A-1a5fH:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cb8 | PROTEIN(CHONDROITINASE AC) (Pedobacterheparinus) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 4 | LEU A 383SER A 384LEU A 296ILE A 409 | None | 0.90A | 3ln1A-1cb8A:0.0 | 3ln1A-1cb8A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dl7 | PROTEIN (ANTIBODYM3C65 (HEAVY CHAIN)) (Mus musculus) |
PF07686(V-set) | 4 | LEU H 85SER H 84LEU H 80TYR H 93 | None | 0.95A | 3ln1A-1dl7H:undetectable | 3ln1A-1dl7H:11.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 6 | ARG A 120LEU A 352SER A 353LEU A 384TYR A 385ILE A 517 | SCL A 700 (-3.9A)SCL A 700 ( 4.8A)NoneNoneNoneNone | 0.46A | 3ln1A-1ebvA:58.3 | 3ln1A-1ebvA:64.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 6 | LEU A 352SER A 353LEU A 384TYR A 385ILE A 517PHE A 518 | SCL A 700 ( 4.8A)NoneNoneNoneNoneNone | 0.78A | 3ln1A-1ebvA:58.3 | 3ln1A-1ebvA:64.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 4 | ARG B1207LEU B1247LEU B1253ILE B1245 | None | 0.95A | 3ln1A-1ej6B:0.0 | 3ln1A-1ej6B:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6u | INTERNALIN H (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6) | 4 | LEU A 163SER A 164LEU A 171ILE A 144 | None | 0.90A | 3ln1A-1h6uA:undetectable | 3ln1A-1h6uA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h8c | FAS-ASSOCIATEDFACTOR 1 (Homo sapiens) |
PF00789(UBX) | 4 | LEU A 65SER A 64LEU A 76ILE A 30 | None | 0.88A | 3ln1A-1h8cA:0.0 | 3ln1A-1h8cA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 4 | LEU A 740LEU A 629ILE A 687PHE A 684 | None | 0.90A | 3ln1A-1j1wA:0.0 | 3ln1A-1j1wA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6r | METHIONINE SYNTHASE (Thermotogamaritima) |
no annotation | 4 | LEU A 82SER A 83LEU A 161ILE A 88 | None | 0.92A | 3ln1A-1j6rA:0.5 | 3ln1A-1j6rA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmk | SURFACTIN SYNTHETASE (Bacillussubtilis) |
PF00975(Thioesterase) | 4 | LEU C 41SER C 38LEU C 175ILE C 21 | None | 0.90A | 3ln1A-1jmkC:undetectable | 3ln1A-1jmkC:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js6 | DOPA DECARBOXYLASE (Sus scrofa) |
PF00282(Pyridoxal_deC) | 4 | LEU A 94LEU A 114ARG A 356ILE A 98 | None | 0.95A | 3ln1A-1js6A:undetectable | 3ln1A-1js6A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsw | L-ASPARTATEAMMONIA-LYASE (Escherichiacoli) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 4 | LEU A 386LEU A 210ILE A 391PHE A 174 | None | 0.91A | 3ln1A-1jswA:undetectable | 3ln1A-1jswA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mn3 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN VPS9 (Saccharomycescerevisiae) |
PF02845(CUE) | 4 | LEU A 400SER A 399LEU A 447ILE A 404 | None | 0.88A | 3ln1A-1mn3A:undetectable | 3ln1A-1mn3A:6.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mu2 | HIV-2 RT (Humanimmunodeficiencyvirus 2) |
PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 4 | LEU B 310SER B 311LEU B 260ILE B 244 | None | 0.82A | 3ln1A-1mu2B:undetectable | 3ln1A-1mu2B:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n8y | PROTOONCOPROTEIN (Rattusnorvegicus) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 5 | LEU C 353SER C 352LEU C 401ILE C 335PHE C 355 | None | 1.31A | 3ln1A-1n8yC:undetectable | 3ln1A-1n8yC:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nex | CDC4 PROTEIN (Saccharomycescerevisiae) |
PF00400(WD40)PF12937(F-box-like) | 5 | LEU B 640SER B 641LEU B 628TYR B 662ILE B 577 | None | 1.49A | 3ln1A-1nexB:undetectable | 3ln1A-1nexB:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnw | HYPOTHETICAL PROTEIN (Pyrococcusfuriosus) |
no annotation | 4 | LEU A 209LEU A 21ILE A 220PHE A 207 | None | 0.87A | 3ln1A-1nnwA:undetectable | 3ln1A-1nnwA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nz8 | TRANSCRIPTIONANTITERMINATIONPROTEIN NUSG (Thermusthermophilus) |
PF02357(NusG) | 4 | LEU A 104SER A 105ARG A 110ILE A 112 | None | 0.77A | 3ln1A-1nz8A:undetectable | 3ln1A-1nz8A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oe5 | SINGLE-STRANDSELECTIVEMONOFUNCTIONALURACIL DNAGLYCOSYLASE (Xenopus laevis) |
no annotation | 4 | LEU A 53SER A 54LEU A 193ILE A 204 | NoneEPE A1285 (-4.5A)NoneNone | 0.93A | 3ln1A-1oe5A:undetectable | 3ln1A-1oe5A:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1or4 | HEME-BASEDAEROTACTICTRANSDUCER HEMAT (Bacillussubtilis) |
PF11563(Protoglobin) | 4 | ARG A 24LEU A 54ILE A 58PHE A 104 | None | 0.93A | 3ln1A-1or4A:undetectable | 3ln1A-1or4A:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p2z | HEXON PROTEIN (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | LEU A 347ARG A 561ILE A 575PHE A 340 | None | 0.90A | 3ln1A-1p2zA:undetectable | 3ln1A-1p2zA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pii | N-(5'PHOSPHORIBOSYL)ANTHRANILATEISOMERASE (Escherichiacoli) |
PF00218(IGPS)PF00697(PRAI) | 4 | LEU A 188LEU A 135ILE A 8PHE A 116 | None | 0.84A | 3ln1A-1piiA:undetectable | 3ln1A-1piiA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1o | CELL DIVISIONCONTROL PROTEIN 24 (Saccharomycescerevisiae) |
PF00564(PB1) | 4 | LEU A 853SER A 767LEU A 794ILE A 802 | None | 0.90A | 3ln1A-1q1oA:undetectable | 3ln1A-1q1oA:9.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qh4 | CREATINE KINASE (Gallus gallus) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 4 | ARG A 130LEU A 121LEU A 317ILE A 361 | None | 0.95A | 3ln1A-1qh4A:undetectable | 3ln1A-1qh4A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r3d | CONSERVEDHYPOTHETICAL PROTEINVC1974 (Vibrio cholerae) |
PF12697(Abhydrolase_6) | 4 | LEU A 152SER A 153LEU A 188ILE A 148 | None | 0.94A | 3ln1A-1r3dA:undetectable | 3ln1A-1r3dA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 5 | LEU A 636SER A 635LEU A 585ARG A 641PHE A 544 | None | 1.44A | 3ln1A-1t6pA:0.0 | 3ln1A-1t6pA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ttx | ONCOMODULIN (Homo sapiens) |
PF13499(EF-hand_7) | 4 | LEU A 64LEU A 36ILE A 98PHE A 103 | None | 0.84A | 3ln1A-1ttxA:undetectable | 3ln1A-1ttxA:12.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua2 | CELL DIVISIONPROTEIN KINASE 7 (Homo sapiens) |
PF00069(Pkinase) | 4 | LEU A 257LEU A 203ILE A 260PHE A 261 | None | 0.94A | 3ln1A-1ua2A:undetectable | 3ln1A-1ua2A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uf2 | CORE PROTEIN P3 (Rice dwarfvirus) |
PF09231(RDV-p3) | 4 | LEU A 686SER A 683ILE A 693PHE A 694 | None | 0.90A | 3ln1A-1uf2A:undetectable | 3ln1A-1uf2A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1um4 | ANTIBODY 21H3 HCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | LEU H 87SER H 86LEU H 82TYR H 95 | None | 0.75A | 3ln1A-1um4H:undetectable | 3ln1A-1um4H:16.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vma | CELL DIVISIONPROTEIN FTSY (Thermotogamaritima) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | LEU A 71SER A 70LEU A 79ARG A 59ILE A 56 | None | 1.37A | 3ln1A-1vmaA:undetectable | 3ln1A-1vmaA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vma | CELL DIVISIONPROTEIN FTSY (Thermotogamaritima) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | LEU A 79LEU A 7ILE A 267PHE A 282 | None | 0.90A | 3ln1A-1vmaA:undetectable | 3ln1A-1vmaA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8j | MYOSIN VA (Gallus gallus) |
PF00063(Myosin_head) | 4 | LEU A 651LEU A 243TYR A 242ILE A 160 | None | 0.87A | 3ln1A-1w8jA:undetectable | 3ln1A-1w8jA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x8v | CYTOCHROME P450 51 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | SER A 148LEU A 204ARG A 158ILE A 153PHE A 157 | None | 1.33A | 3ln1A-1x8vA:0.0 | 3ln1A-1x8vA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xec | DECORIN (Bos taurus) |
PF01462(LRRNT)PF13855(LRR_8) | 4 | LEU A 223SER A 224LEU A 236ILE A 228 | None | 0.92A | 3ln1A-1xecA:undetectable | 3ln1A-1xecA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yf2 | TYPE IRESTRICTION-MODIFICATION ENZYME, SSUBUNIT (Methanocaldococcusjannaschii) |
PF01420(Methylase_S) | 4 | LEU A 25LEU A 153TYR A 141ILE A 118 | None | 0.84A | 3ln1A-1yf2A:undetectable | 3ln1A-1yf2A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z5z | HELICASE OF THESNF2/RAD54 FAMILY (Sulfolobussolfataricus) |
PF00271(Helicase_C) | 4 | LEU A 895SER A 891LEU A 704ILE A 691 | None | 0.88A | 3ln1A-1z5zA:undetectable | 3ln1A-1z5zA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbu | 3'-5' EXONUCLEASEERI1 (Homo sapiens) |
PF00929(RNase_T) | 4 | ARG A 348LEU A 239ILE A 151PHE A 203 | None | 0.76A | 3ln1A-1zbuA:undetectable | 3ln1A-1zbuA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9b | FUSION GLYCOPROTEINF0 (Mammalianrubulavirus 5) |
PF00523(Fusion_gly) | 4 | LEU A 203LEU A 262ILE A 206PHE A 207 | None | 0.82A | 3ln1A-2b9bA:undetectable | 3ln1A-2b9bA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bep | UBIQUITIN-CONJUGATING ENZYME E2-25 KDA (Bos taurus) |
PF00179(UQ_con) | 5 | SER A 85TYR A 51ARG A 74ILE A 91PHE A 75 | None | 1.49A | 3ln1A-2bepA:undetectable | 3ln1A-2bepA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bwj | ADENYLATE KINASE 5 (Homo sapiens) |
PF00406(ADK) | 4 | ARG A 100LEU A 79ILE A 112PHE A 108 | None | 0.94A | 3ln1A-2bwjA:undetectable | 3ln1A-2bwjA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1l | RESTRICTIONENDONUCLEASE (Bacillus firmus) |
PF13091(PLDc_2) | 4 | ARG A 341LEU A 205LEU A 201ILE A 316 | None | 0.72A | 3ln1A-2c1lA:undetectable | 3ln1A-2c1lA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0j | GALACTOSYLGALACTOSYLXYLOSYLPROTEIN3-BETA-GLUCURONOSYLTRANSFERASE 2 (Homo sapiens) |
PF03360(Glyco_transf_43) | 4 | LEU A 181LEU A 277ILE A 85PHE A 183 | None | 0.95A | 3ln1A-2d0jA:undetectable | 3ln1A-2d0jA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfs | MYOSIN-5A (Gallus gallus) |
PF00063(Myosin_head)PF00612(IQ) | 4 | LEU A 651LEU A 243TYR A 242ILE A 160 | None | 0.86A | 3ln1A-2dfsA:undetectable | 3ln1A-2dfsA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewy | BETA-SECRETASE 2 (Homo sapiens) |
PF00026(Asp) | 5 | LEU A 156SER A 155LEU A 187ARG A 359ILE A 162 | None | 1.20A | 3ln1A-2ewyA:undetectable | 3ln1A-2ewyA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fa0 | HMG-COA SYNTHASE (Brassica juncea) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | LEU A 64SER A 63LEU A 78ILE A 70 | None | 0.89A | 3ln1A-2fa0A:undetectable | 3ln1A-2fa0A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fjc | ANTIGEN TPF1 (Treponemapallidum) |
PF00210(Ferritin) | 4 | ARG A 129LEU A 53TYR A 75ILE A 120 | None | 0.88A | 3ln1A-2fjcA:undetectable | 3ln1A-2fjcA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fzf | HYPOTHETICAL PROTEIN (Pyrococcusfuriosus) |
PF02915(Rubrerythrin) | 4 | ARG A 36LEU A 42SER A 41ILE A 46 | None | 0.82A | 3ln1A-2fzfA:undetectable | 3ln1A-2fzfA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEALPHA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF01571(GCV_T)PF07992(Pyr_redox_2)PF08669(GCV_T_C)PF13510(Fer2_4) | 5 | LEU A 690LEU A 657TYR A 654ARG A 687ILE A 637 | None | 1.34A | 3ln1A-2gahA:undetectable | 3ln1A-2gahA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ghw | ANTI-SARS SCFVANTIBODY, 80R (Homo sapiens) |
PF07686(V-set) | 4 | LEU B 179LEU B 210ILE B 190PHE B 194 | None | 0.89A | 3ln1A-2ghwB:undetectable | 3ln1A-2ghwB:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gju | 252AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
no annotation | 4 | LEU A 209LEU A 21ILE A 220PHE A 207 | None | 0.92A | 3ln1A-2gjuA:undetectable | 3ln1A-2gjuA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h32 | IMMUNOGLOBULIN HEAVYCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | LEU H 86SER H 85LEU H 81TYR H 94 | None | 0.83A | 3ln1A-2h32H:undetectable | 3ln1A-2h32H:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h3l | LAP2 PROTEIN (Homo sapiens) |
PF00595(PDZ) | 4 | LEU A1394SER A1393LEU A1404PHE A1398 | None | 0.81A | 3ln1A-2h3lA:undetectable | 3ln1A-2h3lA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi4 | CYTOCHROME P450 1A2 (Homo sapiens) |
PF00067(p450) | 4 | LEU A 497SER A 231LEU A 450ILE A 386 | BHF A 800 (-4.4A)NoneHEM A 900 (-4.0A)HEM A 900 (-4.0A) | 0.69A | 3ln1A-2hi4A:0.0 | 3ln1A-2hi4A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7h | NITROREDUCTASE-LIKEFAMILY PROTEIN (Bacillus cereus) |
PF00881(Nitroreductase) | 4 | ARG A 75LEU A 62ILE A 148PHE A 144 | None | 0.93A | 3ln1A-2i7hA:undetectable | 3ln1A-2i7hA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7x | PROTEIN CFT2 (Saccharomycescerevisiae) |
PF16661(Lactamase_B_6) | 4 | LEU A 149LEU A 134TYR A 88ILE A 167 | None | 0.94A | 3ln1A-2i7xA:undetectable | 3ln1A-2i7xA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ik8 | GUANINENUCLEOTIDE-BINDINGPROTEIN G(I),ALPHA-1 SUBUNIT (Homo sapiens) |
PF00503(G-alpha) | 4 | LEU A 283LEU A 268ILE A 278PHE A 274 | None | 0.91A | 3ln1A-2ik8A:undetectable | 3ln1A-2ik8A:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kr5 | AFLATOXINBIOSYNTHESISPOLYKETIDE SYNTHASE (Aspergillusparasiticus) |
PF00550(PP-binding) | 5 | LEU A 68SER A 67ARG A 55ILE A 50PHE A 54 | None | 1.47A | 3ln1A-2kr5A:undetectable | 3ln1A-2kr5A:9.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 4 | ARG A 90LEU A 319TYR A 29ILE A 64 | None | 0.93A | 3ln1A-2m56A:undetectable | 3ln1A-2m56A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mbg | RALA-BINDING PROTEIN1 (Homo sapiens) |
PF00620(RhoGAP) | 5 | LEU A 267LEU A 278ARG A 214ILE A 217PHE A 213 | None | 1.49A | 3ln1A-2mbgA:1.1 | 3ln1A-2mbgA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mqa | MINOR AMPULLATEFIBROIN 1 (Nephilaantipodiana) |
PF12042(RP1-2) | 4 | LEU A 29SER A 30LEU A 83ILE A 38 | None | 0.89A | 3ln1A-2mqaA:undetectable | 3ln1A-2mqaA:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mvu | ACTINORHODINPOLYKETIDE SYNTHASEACYL CARRIER PROTEIN (Streptomycescoelicolor) |
PF00550(PP-binding) | 4 | LEU A 26SER A 27LEU A 75ILE A 38 | None | 0.92A | 3ln1A-2mvuA:undetectable | 3ln1A-2mvuA:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyt | PROBABLEC->U-EDITING ENZYMEAPOBEC-2 (Homo sapiens) |
PF08210(APOBEC_N) | 4 | LEU A 139SER A 140LEU A 108ILE A 135 | None | 0.95A | 3ln1A-2nytA:undetectable | 3ln1A-2nytA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3i | HYPOTHETICAL PROTEIN (Chromobacteriumviolaceum) |
PF06032(DUF917) | 5 | LEU A 364SER A 365LEU A 302ILE A 369PHE A 373 | None | 1.36A | 3ln1A-2o3iA:undetectable | 3ln1A-2o3iA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o78 | PUTATIVE HISTIDINEAMMONIA-LYASE (Rhodobactersphaeroides) |
PF00221(Lyase_aromatic) | 4 | ARG A 31LEU A 34LEU A 108ILE A 126 | None | 0.79A | 3ln1A-2o78A:0.0 | 3ln1A-2o78A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | LEU A 317ARG A 526ILE A 540PHE A 310 | None | 0.91A | 3ln1A-2obeA:undetectable | 3ln1A-2obeA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odt | INOSITOL-TETRAKISPHOSPHATE 1-KINASE (Homo sapiens) |
PF05770(Ins134_P3_kin) | 4 | LEU X 43SER X 44LEU X 97ILE X 47 | None | 0.93A | 3ln1A-2odtX:undetectable | 3ln1A-2odtX:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogp | PARTITIONING-DEFECTIVE 3 HOMOLOG (Rattusnorvegicus) |
PF00595(PDZ) | 5 | ARG A 109LEU A 74LEU A 27ILE A 38PHE A 36 | None | 1.43A | 3ln1A-2ogpA:undetectable | 3ln1A-2ogpA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2otm | HYPOTHETICAL PROTEIN (Shewanellaoneidensis) |
PF14588(YjgF_endoribonc) | 4 | LEU A 86LEU A 118ILE A 89PHE A 123 | None | 0.83A | 3ln1A-2otmA:undetectable | 3ln1A-2otmA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owz | FRUCTOSE-1,6-BISPHOSPHATASE (Escherichiacoli) |
PF00316(FBPase) | 4 | ARG A 80LEU A 73LEU A 167ILE A 36 | None | 0.94A | 3ln1A-2owzA:undetectable | 3ln1A-2owzA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pg6 | CYTOCHROME P450 2A6 (Homo sapiens) |
PF00067(p450) | 4 | ARG A 76LEU A 370ILE A 366PHE A 480 | NoneHEM A 500 ( 3.8A)HEM A 500 ( 4.1A)None | 0.91A | 3ln1A-2pg6A:0.0 | 3ln1A-2pg6A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phc | UNCHARACTERIZEDPROTEIN PH0987 (Pyrococcushorikoshii) |
PF02682(CT_C_D) | 4 | LEU B 30SER B 29LEU B 12ILE B 34 | None | 0.95A | 3ln1A-2phcB:undetectable | 3ln1A-2phcB:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt5 | SHIKIMATE KINASE (Aquifexaeolicus) |
PF01202(SKI) | 4 | ARG A 22SER A 14LEU A 158ILE A 99 | None | 0.91A | 3ln1A-2pt5A:undetectable | 3ln1A-2pt5A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyj | DNA POLYMERASE (Bacillus virusphi29) |
PF03175(DNA_pol_B_2) | 4 | LEU A 44SER A 43LEU A 58PHE A 13 | None | 0.93A | 3ln1A-2pyjA:undetectable | 3ln1A-2pyjA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyj | DNA POLYMERASE (Bacillus virusphi29) |
PF03175(DNA_pol_B_2) | 4 | LEU A 389SER A 388LEU A 263PHE A 393 | None | 0.94A | 3ln1A-2pyjA:undetectable | 3ln1A-2pyjA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1f | CHONDROITINASE (Bacteroidesthetaiotaomicron) |
PF02278(Lyase_8)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 4 | LEU A 194LEU A 353ARG A 378ILE A 382 | NoneNonePO4 A2002 (-2.5A)None | 0.87A | 3ln1A-2q1fA:undetectable | 3ln1A-2q1fA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9r | PROTEIN OF UNKNOWNFUNCTION (Shewanellabaltica) |
PF04222(DUF416) | 4 | LEU A 164SER A 163ARG A 10ILE A 168 | GOL A 206 ( 4.9A)GOL A 206 (-2.9A)NoneNone | 0.87A | 3ln1A-2q9rA:0.2 | 3ln1A-2q9rA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qby | CELL DIVISIONCONTROL PROTEIN 6HOMOLOG 3 (Sulfolobussolfataricus) |
PF09079(Cdc6_C)PF13401(AAA_22) | 4 | LEU B 113SER B 111LEU B 165ILE B 136 | None | 0.95A | 3ln1A-2qbyB:undetectable | 3ln1A-2qbyB:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4s | ANTIBODY FOR BETA2ADRENOCEPTOR, LIGHTCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | LEU L 78SER L 77LEU L 73TYR L 86 | None | 0.85A | 3ln1A-2r4sL:undetectable | 3ln1A-2r4sL:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v95 | CORTICOSTEROID-BINDING GLOBULIN (Rattusnorvegicus) |
PF00079(Serpin) | 4 | LEU A 269LEU A 354ILE A 346PHE A 348 | None | 0.95A | 3ln1A-2v95A:undetectable | 3ln1A-2v95A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsq | SURFACTIN SYNTHETASESUBUNIT 3 (Bacillussubtilis) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 4 | LEU A1081SER A1078LEU A1215ILE A1061 | None | 0.84A | 3ln1A-2vsqA:undetectable | 3ln1A-2vsqA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wb7 | PT26-6P (Thermococcussp. 26-2) |
no annotation | 4 | LEU A 218ARG A 258ILE A 232PHE A 257 | None | 0.86A | 3ln1A-2wb7A:undetectable | 3ln1A-2wb7A:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wya | HYDROXYMETHYLGLUTARYL-COA SYNTHASE,MITOCHONDRIAL (Homo sapiens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | SER A 272LEU A 292ILE A 277PHE A 290 | None | 0.95A | 3ln1A-2wyaA:undetectable | 3ln1A-2wyaA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzi | EXTRACELLULARSIALIDASE/NEURAMINIDASE, PUTATIVE (Aspergillusfumigatus) |
PF13088(BNR_2) | 5 | LEU A 372SER A 359LEU A 90ARG A 59ILE A 390 | NoneNoneNoneKDM A 500 (-2.7A)None | 1.26A | 3ln1A-2xziA:undetectable | 3ln1A-2xziA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzl | ATP-DEPENDENTHELICASE NAM7 (Saccharomycescerevisiae) |
PF09416(UPF1_Zn_bind)PF13086(AAA_11)PF13087(AAA_12) | 4 | LEU A 620LEU A 365TYR A 238ILE A 586 | None | 0.95A | 3ln1A-2xzlA:undetectable | 3ln1A-2xzlA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7d | 3-KETO-5-AMINOHEXANOATE CLEAVAGE ENZYME (CandidatusCloacimonasacidaminovorans) |
PF05853(BKACE) | 4 | LEU A 47LEU A 23ARG A 226ILE A 45 | NoneNone ZN A 301 ( 4.2A)None | 0.81A | 3ln1A-2y7dA:undetectable | 3ln1A-2y7dA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yp2 | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | LEU A 177LEU A 66ARG A 150ILE A 179 | None | 0.68A | 3ln1A-2yp2A:undetectable | 3ln1A-2yp2A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywq | RIBOSOMAL SUBUNITINTERFACE PROTEIN (Thermusthermophilus) |
PF02482(Ribosomal_S30AE) | 4 | ARG A 68LEU A 42LEU A 25ILE A 13 | None | 0.69A | 3ln1A-2ywqA:undetectable | 3ln1A-2ywqA:10.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1u | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPE (Desulfovibriovulgaris) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | LEU A 24ARG A 117ILE A 123PHE A 29 | None | 0.86A | 3ln1A-2z1uA:undetectable | 3ln1A-2z1uA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zau | SELENIDE, WATERDIKINASE (Aquifexaeolicus) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | LEU A 289SER A 290LEU A 166ILE A 172 | None | 0.80A | 3ln1A-2zauA:undetectable | 3ln1A-2zauA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ajf | NON-STRUCTURALPROTEIN 3 (Rice hojablancatenuivirus) |
PF05310(Tenui_NS3) | 4 | LEU A 42SER A 41LEU A 83ILE A 46 | None | 0.86A | 3ln1A-3ajfA:undetectable | 3ln1A-3ajfA:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3amj | ZINC PEPTIDASEACTIVE SUBUNIT (Sphingomonassp. A1) |
no annotation | 4 | LEU C 374SER C 375ARG C 420ILE C 296 | None | 0.94A | 3ln1A-3amjC:undetectable | 3ln1A-3amjC:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqs | BACTERIAL REGULATORYPROTEINS, TETRFAMILY (Corynebacteriumglutamicum) |
PF00440(TetR_N) | 4 | LEU A 175SER A 174ILE A 179PHE A 128 | None | 0.70A | 3ln1A-3aqsA:undetectable | 3ln1A-3aqsA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3atb | POTASSIUMINWARDLY-RECTIFYINGCHANNEL, SUBFAMILYJ, MEMBER 6 (Mus musculus) |
PF01007(IRK) | 4 | LEU A 299SER A 295LEU A 243ILE A 213 | None | 0.80A | 3ln1A-3atbA:undetectable | 3ln1A-3atbA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3auw | POTASSIUMINWARDLY-RECTIFYINGCHANNEL, SUBFAMILYJ, MEMBER 6 (Mus musculus) |
PF01007(IRK) | 4 | LEU B 299SER B 295LEU B 243ILE B 213 | None | 0.94A | 3ln1A-3auwB:undetectable | 3ln1A-3auwB:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | LEU A 281LEU A 313ILE A 263PHE A 286 | None | 0.95A | 3ln1A-3b2dA:undetectable | 3ln1A-3b2dA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | LEU A 540SER A 541LEU A 574ILE A 546 | None | 0.75A | 3ln1A-3b2dA:undetectable | 3ln1A-3b2dA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | LEU A 574SER A 575LEU A 589ILE A 555 | None | 0.94A | 3ln1A-3b2dA:undetectable | 3ln1A-3b2dA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b89 | 16S RRNA METHYLASE (Escherichiacoli) |
PF07091(FmrO) | 4 | ARG A 181LEU A 176LEU A 159ILE A 172 | NoneNone5GP A 500 ( 4.3A)None | 0.88A | 3ln1A-3b89A:undetectable | 3ln1A-3b89A:17.66 |