SIMILAR PATTERNS OF AMINO ACIDS FOR 3LN1_A_CELA682

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A 152
VAL A  68
GLY A  70
ALA A  69
LEU A  90
 1BH  A 300 ( 3.7A)
None
None
None
None
 1.05A 3ln1A-1bh6A:
undetectable		 3ln1A-1bh6A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A 152
VAL A  68
GLY A  70
ALA A  69
LEU A  90
 XE  A 281 ( 3.9A)
None
None
None
None
 1.04A 3ln1A-1c3lA:
undetectable		 3ln1A-1c3lA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 HIS A  57
VAL A  91
LEU A  95
GLY A  49
LEU A  78
 None
None
None
NAP  A 386 (-3.2A)
None
 1.07A 3ln1A-1civA:
0.0		 3ln1A-1civA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.31A 3ln1A-1ebvA:
58.3		 3ln1A-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 LEU A 185
ALA B 422
VAL B 409
GLY B 356
SER A 188
 None
 1.04A 3ln1A-1gxsA:
0.5		 3ln1A-1gxsA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 182
ALA A 167
VAL A 235
GLY A  10
ALA A  82
 None
 0.95A 3ln1A-1j3nA:
0.0		 3ln1A-1j3nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 237
LEU A 182
ALA A 167
ALA A  79
LEU A  83
 None
 1.00A 3ln1A-1j3nA:
0.0		 3ln1A-1j3nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 VAL A 152
ALA A 126
VAL A 363
GLY A 361
LEU A 356
 None
None
None
None
HEM  A 410 ( 4.4A)
 1.02A 3ln1A-1jioA:
0.0		 3ln1A-1jioA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.99A 3ln1A-1jy1A:
0.0		 3ln1A-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C  21
ALA C  46
GLY C  33
ALA C  32
LEU C  54
 None
None
FAD  C3932 (-3.4A)
FAD  C3932 (-3.5A)
None
 1.01A 3ln1A-1n61C:
undetectable		 3ln1A-1n61C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.92A 3ln1A-1nvtA:
undetectable		 3ln1A-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		5 VAL A 183
LEU A 148
ALA A 132
GLY A 202
ALA A 201
 None
 1.00A 3ln1A-1p0nA:
undetectable		 3ln1A-1p0nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 HIS A 125
LEU A 278
ALA A  56
ALA A  82
LEU A  50
 NAP  A 500 ( 4.8A)
NAP  A 500 (-4.0A)
None
None
None
 1.07A 3ln1A-1pz1A:
undetectable		 3ln1A-1pz1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178

(Aquifex
aeolicus) 		PF00582
(Usp) 		5 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.99A 3ln1A-1q77A:
undetectable		 3ln1A-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 VAL A  46
ALA A  38
VAL A  14
GLY A  17
LEU A 219
 VAL  A  46 ( 0.6A)
ALA  A  38 ( 0.0A)
VAL  A  14 ( 0.6A)
GLY  A  17 ( 0.0A)
LEU  A 219 ( 0.6A)
 0.95A 3ln1A-1rrvA:
1.3		 3ln1A-1rrvA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
 None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
 1.05A 3ln1A-1sezA:
undetectable		 3ln1A-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 1.04A 3ln1A-1uaaA:
undetectable		 3ln1A-1uaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 1.04A 3ln1A-2aizP:
undetectable		 3ln1A-2aizP:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 1.02A 3ln1A-2cb1A:
undetectable		 3ln1A-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 196
LEU A 189
ALA A  90
GLY A 213
ALA A 214
 None
 0.97A 3ln1A-2cb1A:
undetectable		 3ln1A-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 LEU A 381
ALA A  35
VAL A  16
GLY A   6
ALA A   5
 None
 1.02A 3ln1A-2d0oA:
undetectable		 3ln1A-2d0oA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
 PMS  A 601 ( 3.8A)
None
None
None
None
 0.96A 3ln1A-2gkoA:
undetectable		 3ln1A-2gkoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 0.98A 3ln1A-2hfsA:
undetectable		 3ln1A-2hfsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4k GENERAL STRESS
PROTEIN 13

(Bacillus
subtilis) 		PF00575
(S1) 		5 ALA A  78
VAL A  35
GLY A  22
ALA A  23
LEU A  18
 None
 0.96A 3ln1A-2k4kA:
undetectable		 3ln1A-2k4kA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzc HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		no annotation 5 LEU A  51
VAL A  73
GLY A  68
SER A  64
LEU A  63
 None
 0.97A 3ln1A-2nzcA:
undetectable		 3ln1A-2nzcA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		5 ALA A 257
VAL A  16
GLY A  18
ALA A  19
LEU A  65
 None
 1.06A 3ln1A-2o5rA:
undetectable		 3ln1A-2o5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
vanbaalenii) 		PF00440
(TetR_N) 		5 VAL A  47
LEU A  57
ALA A  10
GLY A  41
ALA A  40
 None
 0.91A 3ln1A-2qwtA:
undetectable		 3ln1A-2qwtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 659
ALA A 299
VAL A 437
GLY A 653
ALA A 654
 None
 0.92A 3ln1A-2wjvA:
undetectable		 3ln1A-2wjvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 LEU A  79
ALA A 148
VAL A  70
GLY A  72
ALA A  75
 None
 1.05A 3ln1A-2wsxA:
1.9		 3ln1A-2wsxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ALA A 223
VAL A 235
GLY A 238
ALA A 241
LEU A 244
 None
 1.05A 3ln1A-2xgtA:
undetectable		 3ln1A-2xgtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 VAL A 108
ALA A 438
GLY A 160
ALA A 159
SER A 156
 None
 0.95A 3ln1A-2y2wA:
undetectable		 3ln1A-2y2wA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.92A 3ln1A-2yr5A:
undetectable		 3ln1A-2yr5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 567
ALA A 533
ALA A 549
SER A 551
LEU A 552
 None
 0.86A 3ln1A-3b9pA:
undetectable		 3ln1A-3b9pA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhq TRANSCRIPTIONAL
REGULATOR

(Mesorhizobium
japonicum) 		PF00440
(TetR_N)
PF14246
(TetR_C_7) 		5 VAL A  48
LEU A  58
ALA A  10
GLY A  42
ALA A  41
 None
 1.04A 3ln1A-3bhqA:
0.3		 3ln1A-3bhqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 ALA A 166
VAL A  75
GLY A  77
ALA A  76
LEU A  99
 None
 1.04A 3ln1A-3d43A:
undetectable		 3ln1A-3d43A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacteroides
thetaiotaomicron) 		PF13460
(NAD_binding_10) 		5 VAL A  31
LEU A  25
VAL A  35
GLY A  11
ALA A  12
 None
 1.03A 3ln1A-3dhnA:
undetectable		 3ln1A-3dhnA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 5 ALA A2023
VAL A2062
ALA A2066
SER A2068
LEU A2069
 None
 0.86A 3ln1A-3dyjA:
undetectable		 3ln1A-3dyjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 380
VAL A 267
ALA A 271
SER A 274
LEU A 275
 None
 1.07A 3ln1A-3e1hA:
undetectable		 3ln1A-3e1hA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		5 ALA A 161
VAL A  12
GLY A  14
ALA A 167
SER A 168
 None
None
FAD  A 600 (-3.2A)
None
FAD  A 600 (-4.2A)
 1.08A 3ln1A-3e1tA:
undetectable		 3ln1A-3e1tA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		5 VAL A 236
LEU A 225
ALA A 110
GLY A 205
ALA A 206
 None
 1.04A 3ln1A-3f7wA:
undetectable		 3ln1A-3f7wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 5 ALA A2032
VAL A2071
ALA A2075
SER A2077
LEU A2078
 None
 0.99A 3ln1A-3fyqA:
undetectable		 3ln1A-3fyqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 457
ALA A 495
VAL A 113
GLY A 112
ALA A 111
 HBX  A 530 (-4.3A)
None
FAD  A 522 (-3.7A)
FAD  A 522 (-3.9A)
FAD  A 522 ( 3.0A)
 0.92A 3ln1A-3gdnA:
undetectable		 3ln1A-3gdnA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.88A 3ln1A-3h6eA:
0.5		 3ln1A-3h6eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE

(Methylococcus
capsulatus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.07A 3ln1A-3i83A:
undetectable		 3ln1A-3i83A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwa FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Desulfovibrio
vulgaris) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 HIS A  96
TYR A 113
GLY A 266
ALA A 265
LEU A 261
 None
 1.03A 3ln1A-3iwaA:
undetectable		 3ln1A-3iwaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 LEU A 398
ALA A 193
ALA A 165
SER A 168
LEU A 169
 None
 0.85A 3ln1A-3j1eA:
undetectable		 3ln1A-3j1eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 108
LEU A 112
GLY A  76
SER A  79
LEU A  80
 None
None
AKG  A 224 (-3.1A)
None
None
 1.05A 3ln1A-3la2A:
undetectable		 3ln1A-3la2A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 155
LEU A 163
ALA A 171
GLY A 214
ALA A 215
 None
 0.91A 3ln1A-3mi9A:
undetectable		 3ln1A-3mi9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		6 VAL A 518
ALA A 627
GLY A 543
ALA A 546
SER A 545
LEU A 549
 None
 1.37A 3ln1A-3o4zA:
undetectable		 3ln1A-3o4zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 VAL A 310
LEU A 314
ALA A 295
GLY A 268
ALA A 269
 None
 1.06A 3ln1A-3pl2A:
undetectable		 3ln1A-3pl2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A 458
ALA A 496
VAL A 113
GLY A 112
ALA A 111
 None
None
FAD  A 773 (-3.7A)
FAD  A 773 (-3.9A)
FAD  A 773 (-3.0A)
 0.96A 3ln1A-3redA:
undetectable		 3ln1A-3redA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.02A 3ln1A-4b4uA:
undetectable		 3ln1A-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 VAL A 165
LEU A  61
ALA A 184
GLY A 112
LEU A 118
 None
 1.08A 3ln1A-4iheA:
undetectable		 3ln1A-4iheA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 VAL B 176
ALA B 359
GLY B 274
ALA B 273
SER B  54
 None
 1.04A 3ln1A-4iu9B:
undetectable		 3ln1A-4iu9B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.76A 3ln1A-4j9uA:
3.4		 3ln1A-4j9uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 TYR A 165
LEU A 245
ALA A 131
GLY A 276
ALA A 275
 None
None
NAP  A 402 ( 3.3A)
None
None
 1.04A 3ln1A-4jb1A:
undetectable		 3ln1A-4jb1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		5 VAL A 178
ALA A 362
GLY A 276
ALA A 275
SER A  56
 None
 0.91A 3ln1A-4jreA:
undetectable		 3ln1A-4jreA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 687
ALA A 659
GLY A 675
SER A 522
LEU A 530
 None
 0.92A 3ln1A-4k3jA:
undetectable		 3ln1A-4k3jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		5 VAL A 253
LEU A 227
GLY A 246
ALA A 245
LEU A 241
 None
 1.06A 3ln1A-4kl0A:
undetectable		 3ln1A-4kl0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky9 BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 GLN A  62
VAL A 267
LEU A 269
ALA A 132
LEU A 136
 None
 1.02A 3ln1A-4ky9A:
undetectable		 3ln1A-4ky9A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 TYR A 209
LEU A 204
ALA A 216
GLY A 234
LEU A 238
 None
MFK  A 401 (-4.6A)
None
MFK  A 401 ( 3.9A)
MFK  A 401 (-4.6A)
 0.84A 3ln1A-4mfzA:
undetectable		 3ln1A-4mfzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nng 30S RIBOSOMAL
PROTEIN S1

(Mycobacterium
tuberculosis) 		PF00575
(S1) 		5 ALA A 365
VAL A 321
GLY A 308
ALA A 309
LEU A 304
 None
 1.05A 3ln1A-4nngA:
undetectable		 3ln1A-4nngA:
15.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 HIS A  90
GLN A 193
VAL A 350
TYR A 356
LEU A 360
TRP A 388
ALA A 517
VAL A 524
GLY A 527
ALA A 528
SER A 531
LEU A 532
 None
None
IBP  A 601 (-4.3A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.53A 3ln1A-4ph9A:
63.8		 3ln1A-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 VAL A1006
LEU A 524
VAL A 967
GLY A 969
ALA A 968
 None
 0.94A 3ln1A-4pj6A:
undetectable		 3ln1A-4pj6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 TYR A 209
LEU A 204
ALA A 216
GLY A 234
SER A 236
 None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
COA  A 403 (-3.1A)
 0.98A 3ln1A-4q38A:
undetectable		 3ln1A-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 VAL A 197
TYR A 209
LEU A 204
ALA A 216
GLY A 234
 TEC  A 404 ( 4.2A)
None
COA  A 403 (-4.6A)
None
TEC  A 404 ( 3.9A)
 0.89A 3ln1A-4q38A:
undetectable		 3ln1A-4q38A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		5 HIS A 258
LEU A 318
VAL A 327
GLY A 337
SER A 335
 None
 1.00A 3ln1A-4q8kA:
undetectable		 3ln1A-4q8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		5 HIS A  91
LEU A 151
VAL A 160
GLY A 170
SER A 168
 None
 0.95A 3ln1A-4q8lA:
undetectable		 3ln1A-4q8lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 HIS A 279
TYR A 423
ALA A 262
GLY A 286
SER A 329
 None
 1.02A 3ln1A-4r1dA:
undetectable		 3ln1A-4r1dA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		5 GLN A 176
VAL A 169
GLY A 229
ALA A 232
LEU A 154
 None
 1.01A 3ln1A-4r86A:
undetectable		 3ln1A-4r86A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 LEU A 209
ALA A  95
VAL A  82
GLY A  80
ALA A  79
 None
 1.05A 3ln1A-4rncA:
undetectable		 3ln1A-4rncA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 GLN A 254
GLY A 356
ALA A 357
SER A 360
LEU A 361
 None
 1.01A 3ln1A-4rt6A:
undetectable		 3ln1A-4rt6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		5 VAL A 309
ALA A  28
VAL A  41
GLY A  74
ALA A  42
 NA  A1340 (-3.7A)
None
None
None
None
 0.93A 3ln1A-4us5A:
undetectable		 3ln1A-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		6 GLN A 146
LEU A  24
VAL A 126
GLY A  37
ALA A  38
SER A  72
 None
 1.24A 3ln1A-4yxmA:
undetectable		 3ln1A-4yxmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  98
ALA A 122
VAL A 164
GLY A   7
ALA A  62
 None
 1.00A 3ln1A-4z19A:
undetectable		 3ln1A-4z19A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.74A 3ln1A-4zqbA:
undetectable		 3ln1A-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 LEU A 428
ALA A 366
VAL A 332
ALA A 336
LEU A 340
 None
None
None
SRT  A1568 (-4.3A)
EDO  A1577 (-4.5A)
 1.08A 3ln1A-5a29A:
undetectable		 3ln1A-5a29A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.05A 3ln1A-5a4jA:
undetectable		 3ln1A-5a4jA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbn ACETATE
COA-TRANSFERASE
SUBUNIT BETA

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 VAL B  21
LEU B  43
VAL B  11
ALA B  12
LEU B  35
 None
 1.06A 3ln1A-5dbnB:
undetectable		 3ln1A-5dbnB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLN A 375
LEU A 290
GLY A 305
ALA A 304
LEU A 282
 None
 1.02A 3ln1A-5dotA:
undetectable		 3ln1A-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 VAL A 425
ALA A 513
GLY A 535
ALA A 742
LEU A 743
 None
 0.95A 3ln1A-5dotA:
undetectable		 3ln1A-5dotA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dus ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		5 VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
 None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
 0.93A 3ln1A-5dusA:
undetectable		 3ln1A-5dusA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exx TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		5 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.02A 3ln1A-5exxA:
undetectable		 3ln1A-5exxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 1.05A 3ln1A-5f4zA:
undetectable		 3ln1A-5f4zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ALA A 158
VAL A  72
GLY A  74
ALA A  73
LEU A  91
 None
None
5VV  A   1 ( 4.8A)
None
None
 0.94A 3ln1A-5fbzA:
undetectable		 3ln1A-5fbzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 ALA A 167
VAL A  76
GLY A  78
ALA A  77
LEU A 100
 None
 1.01A 3ln1A-5ffnA:
undetectable		 3ln1A-5ffnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii) 		PF08541
(ACP_syn_III_C) 		5 VAL A 149
LEU A  90
ALA A 341
GLY A  76
LEU A  84
 None
 1.00A 3ln1A-5gk2A:
undetectable		 3ln1A-5gk2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 LEU A 220
ALA A  95
GLY A 173
ALA A 174
LEU A 200
 None
 1.08A 3ln1A-5gw8A:
undetectable		 3ln1A-5gw8A:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.32A 3ln1A-5ikrA:
62.4		 3ln1A-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8v DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Pyrococcus
furiosus) 		PF08423
(Rad51) 		5 VAL A 313
LEU A 124
ALA A 309
VAL A 281
LEU A 147
 None
 1.08A 3ln1A-5l8vA:
undetectable		 3ln1A-5l8vA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF02669
(KdpC)
PF03814
(KdpA) 		5 GLN C 173
VAL C 118
VAL A 303
GLY A 305
LEU A 310
 None
 1.02A 3ln1A-5mrwC:
undetectable		 3ln1A-5mrwC:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 0.91A 3ln1A-5ohsA:
undetectable		 3ln1A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr3 DIHYDROLIPOYL
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 144
VAL A   9
GLY A  11
ALA A 150
SER A 151
 None
None
FAD  A 501 (-3.4A)
None
FAD  A 501 (-4.6A)
 1.08A 3ln1A-5tr3A:
undetectable		 3ln1A-5tr3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		5 HIS A1714
VAL A1655
LEU A1690
ALA A1718
GLY A1531
 None
 1.07A 3ln1A-5v41A:
0.5		 3ln1A-5v41A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		no annotation 5 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.07A 3ln1A-5y09A:
undetectable		 3ln1A-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 5 ALA A  70
GLY A 192
ALA A 191
SER A 190
LEU A 248
 None
LLP  A  63 ( 3.3A)
LLP  A  63 ( 3.5A)
LLP  A  63 ( 4.2A)
None
 1.02A 3ln1A-5ybwA:
undetectable		 3ln1A-5ybwA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ALA A 160
VAL A  77
GLY A  80
ALA A  81
LEU A  85
 None
 0.68A 3ln1A-5yvsA:
undetectable		 3ln1A-5yvsA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 5 VAL A 160
ALA A 520
GLY A 559
ALA A 560
SER A 156
 None
GOL  A 701 (-3.4A)
None
None
None
 0.90A 3ln1A-5zl9A:
undetectable		 3ln1A-5zl9A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A 186
LEU A 187
VAL A 239
ALA A 243
LEU A 247
 None
None
None
None
CLR  A1202 ( 4.3A)
 1.02A 3ln1A-6aqfA:
undetectable		 3ln1A-6aqfA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 5 LEU A  26
ALA A 118
GLY A 179
ALA A 262
SER A 264
 None
COA  A 301 (-3.3A)
None
None
None
 1.06A 3ln1A-6bc5A:
undetectable		 3ln1A-6bc5A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5f MONOCLONAL
ANTI-E-SELECTIN 7A9
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  86
SER H  85
LEU H  81
TYR H  94
 None
 0.88A 3ln1A-1a5fH:
0.0		 3ln1A-1a5fH:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 383
SER A 384
LEU A 296
ILE A 409
 None
 0.90A 3ln1A-1cb8A:
0.0		 3ln1A-1cb8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl7 PROTEIN (ANTIBODY
M3C65 (HEAVY CHAIN))

(Mus musculus) 		PF07686
(V-set) 		4 LEU H  85
SER H  84
LEU H  80
TYR H  93
 None
 0.95A 3ln1A-1dl7H:
undetectable		 3ln1A-1dl7H:
11.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 ARG A 120
LEU A 352
SER A 353
LEU A 384
TYR A 385
ILE A 517
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
None
None
None
None
 0.46A 3ln1A-1ebvA:
58.3		 3ln1A-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 LEU A 352
SER A 353
LEU A 384
TYR A 385
ILE A 517
PHE A 518
 SCL  A 700 ( 4.8A)
None
None
None
None
None
 0.78A 3ln1A-1ebvA:
58.3		 3ln1A-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 ARG B1207
LEU B1247
LEU B1253
ILE B1245
 None
 0.95A 3ln1A-1ej6B:
0.0		 3ln1A-1ej6B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 LEU A 163
SER A 164
LEU A 171
ILE A 144
 None
 0.90A 3ln1A-1h6uA:
undetectable		 3ln1A-1h6uA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8c FAS-ASSOCIATED
FACTOR 1

(Homo sapiens) 		PF00789
(UBX) 		4 LEU A  65
SER A  64
LEU A  76
ILE A  30
 None
 0.88A 3ln1A-1h8cA:
0.0		 3ln1A-1h8cA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 LEU A 740
LEU A 629
ILE A 687
PHE A 684
 None
 0.90A 3ln1A-1j1wA:
0.0		 3ln1A-1j1wA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6r METHIONINE SYNTHASE

(Thermotoga
maritima) 		no annotation 4 LEU A  82
SER A  83
LEU A 161
ILE A  88
 None
 0.92A 3ln1A-1j6rA:
0.5		 3ln1A-1j6rA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 LEU C  41
SER C  38
LEU C 175
ILE C  21
 None
 0.90A 3ln1A-1jmkC:
undetectable		 3ln1A-1jmkC:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A  94
LEU A 114
ARG A 356
ILE A  98
 None
 0.95A 3ln1A-1js6A:
undetectable		 3ln1A-1js6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 386
LEU A 210
ILE A 391
PHE A 174
 None
 0.91A 3ln1A-1jswA:
undetectable		 3ln1A-1jswA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Saccharomyces
cerevisiae) 		PF02845
(CUE) 		4 LEU A 400
SER A 399
LEU A 447
ILE A 404
 None
 0.88A 3ln1A-1mn3A:
undetectable		 3ln1A-1mn3A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU B 310
SER B 311
LEU B 260
ILE B 244
 None
 0.82A 3ln1A-1mu2B:
undetectable		 3ln1A-1mu2B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU C 353
SER C 352
LEU C 401
ILE C 335
PHE C 355
 None
 1.31A 3ln1A-1n8yC:
undetectable		 3ln1A-1n8yC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CDC4 PROTEIN

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12937
(F-box-like) 		5 LEU B 640
SER B 641
LEU B 628
TYR B 662
ILE B 577
 None
 1.49A 3ln1A-1nexB:
undetectable		 3ln1A-1nexB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 LEU A 209
LEU A  21
ILE A 220
PHE A 207
 None
 0.87A 3ln1A-1nnwA:
undetectable		 3ln1A-1nnwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nz8 TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermus
thermophilus) 		PF02357
(NusG) 		4 LEU A 104
SER A 105
ARG A 110
ILE A 112
 None
 0.77A 3ln1A-1nz8A:
undetectable		 3ln1A-1nz8A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE

(Xenopus laevis) 		no annotation 4 LEU A  53
SER A  54
LEU A 193
ILE A 204
 None
EPE  A1285 (-4.5A)
None
None
 0.93A 3ln1A-1oe5A:
undetectable		 3ln1A-1oe5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT

(Bacillus
subtilis) 		PF11563
(Protoglobin) 		4 ARG A  24
LEU A  54
ILE A  58
PHE A 104
 None
 0.93A 3ln1A-1or4A:
undetectable		 3ln1A-1or4A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 LEU A 347
ARG A 561
ILE A 575
PHE A 340
 None
 0.90A 3ln1A-1p2zA:
undetectable		 3ln1A-1p2zA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		4 LEU A 188
LEU A 135
ILE A   8
PHE A 116
 None
 0.84A 3ln1A-1piiA:
undetectable		 3ln1A-1piiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1o CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		4 LEU A 853
SER A 767
LEU A 794
ILE A 802
 None
 0.90A 3ln1A-1q1oA:
undetectable		 3ln1A-1q1oA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ARG A 130
LEU A 121
LEU A 317
ILE A 361
 None
 0.95A 3ln1A-1qh4A:
undetectable		 3ln1A-1qh4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		4 LEU A 152
SER A 153
LEU A 188
ILE A 148
 None
 0.94A 3ln1A-1r3dA:
undetectable		 3ln1A-1r3dA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 636
SER A 635
LEU A 585
ARG A 641
PHE A 544
 None
 1.44A 3ln1A-1t6pA:
0.0		 3ln1A-1t6pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU A  64
LEU A  36
ILE A  98
PHE A 103
 None
 0.84A 3ln1A-1ttxA:
undetectable		 3ln1A-1ttxA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 257
LEU A 203
ILE A 260
PHE A 261
 None
 0.94A 3ln1A-1ua2A:
undetectable		 3ln1A-1ua2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 LEU A 686
SER A 683
ILE A 693
PHE A 694
 None
 0.90A 3ln1A-1uf2A:
undetectable		 3ln1A-1uf2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um4 ANTIBODY 21H3 H
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  87
SER H  86
LEU H  82
TYR H  95
 None
 0.75A 3ln1A-1um4H:
undetectable		 3ln1A-1um4H:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A  71
SER A  70
LEU A  79
ARG A  59
ILE A  56
 None
 1.37A 3ln1A-1vmaA:
undetectable		 3ln1A-1vmaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A  79
LEU A   7
ILE A 267
PHE A 282
 None
 0.90A 3ln1A-1vmaA:
undetectable		 3ln1A-1vmaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		4 LEU A 651
LEU A 243
TYR A 242
ILE A 160
 None
 0.87A 3ln1A-1w8jA:
undetectable		 3ln1A-1w8jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 SER A 148
LEU A 204
ARG A 158
ILE A 153
PHE A 157
 None
 1.33A 3ln1A-1x8vA:
0.0		 3ln1A-1x8vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 223
SER A 224
LEU A 236
ILE A 228
 None
 0.92A 3ln1A-1xecA:
undetectable		 3ln1A-1xecA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		4 LEU A  25
LEU A 153
TYR A 141
ILE A 118
 None
 0.84A 3ln1A-1yf2A:
undetectable		 3ln1A-1yf2A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5z HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00271
(Helicase_C) 		4 LEU A 895
SER A 891
LEU A 704
ILE A 691
 None
 0.88A 3ln1A-1z5zA:
undetectable		 3ln1A-1z5zA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 ARG A 348
LEU A 239
ILE A 151
PHE A 203
 None
 0.76A 3ln1A-1zbuA:
undetectable		 3ln1A-1zbuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 203
LEU A 262
ILE A 206
PHE A 207
 None
 0.82A 3ln1A-2b9bA:
undetectable		 3ln1A-2b9bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bep UBIQUITIN-CONJUGATIN
G ENZYME E2-25 KDA

(Bos taurus) 		PF00179
(UQ_con) 		5 SER A  85
TYR A  51
ARG A  74
ILE A  91
PHE A  75
 None
 1.49A 3ln1A-2bepA:
undetectable		 3ln1A-2bepA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwj ADENYLATE KINASE 5

(Homo sapiens) 		PF00406
(ADK) 		4 ARG A 100
LEU A  79
ILE A 112
PHE A 108
 None
 0.94A 3ln1A-2bwjA:
undetectable		 3ln1A-2bwjA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		4 ARG A 341
LEU A 205
LEU A 201
ILE A 316
 None
 0.72A 3ln1A-2c1lA:
undetectable		 3ln1A-2c1lA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 LEU A 181
LEU A 277
ILE A  85
PHE A 183
 None
 0.95A 3ln1A-2d0jA:
undetectable		 3ln1A-2d0jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 LEU A 651
LEU A 243
TYR A 242
ILE A 160
 None
 0.86A 3ln1A-2dfsA:
undetectable		 3ln1A-2dfsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		5 LEU A 156
SER A 155
LEU A 187
ARG A 359
ILE A 162
 None
 1.20A 3ln1A-2ewyA:
undetectable		 3ln1A-2ewyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A  64
SER A  63
LEU A  78
ILE A  70
 None
 0.89A 3ln1A-2fa0A:
undetectable		 3ln1A-2fa0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjc ANTIGEN TPF1

(Treponema
pallidum) 		PF00210
(Ferritin) 		4 ARG A 129
LEU A  53
TYR A  75
ILE A 120
 None
 0.88A 3ln1A-2fjcA:
undetectable		 3ln1A-2fjcA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzf HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02915
(Rubrerythrin) 		4 ARG A  36
LEU A  42
SER A  41
ILE A  46
 None
 0.82A 3ln1A-2fzfA:
undetectable		 3ln1A-2fzfA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 LEU A 690
LEU A 657
TYR A 654
ARG A 687
ILE A 637
 None
 1.34A 3ln1A-2gahA:
undetectable		 3ln1A-2gahA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghw ANTI-SARS SCFV
ANTIBODY, 80R

(Homo sapiens) 		PF07686
(V-set) 		4 LEU B 179
LEU B 210
ILE B 190
PHE B 194
 None
 0.89A 3ln1A-2ghwB:
undetectable		 3ln1A-2ghwB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 4 LEU A 209
LEU A  21
ILE A 220
PHE A 207
 None
 0.92A 3ln1A-2gjuA:
undetectable		 3ln1A-2gjuA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h32 IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  86
SER H  85
LEU H  81
TYR H  94
 None
 0.83A 3ln1A-2h32H:
undetectable		 3ln1A-2h32H:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3l LAP2 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A1394
SER A1393
LEU A1404
PHE A1398
 None
 0.81A 3ln1A-2h3lA:
undetectable		 3ln1A-2h3lA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 497
SER A 231
LEU A 450
ILE A 386
 BHF  A 800 (-4.4A)
None
HEM  A 900 (-4.0A)
HEM  A 900 (-4.0A)
 0.69A 3ln1A-2hi4A:
0.0		 3ln1A-2hi4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7h NITROREDUCTASE-LIKE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 ARG A  75
LEU A  62
ILE A 148
PHE A 144
 None
 0.93A 3ln1A-2i7hA:
undetectable		 3ln1A-2i7hA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 LEU A 149
LEU A 134
TYR A  88
ILE A 167
 None
 0.94A 3ln1A-2i7xA:
undetectable		 3ln1A-2i7xA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT

(Homo sapiens) 		PF00503
(G-alpha) 		4 LEU A 283
LEU A 268
ILE A 278
PHE A 274
 None
 0.91A 3ln1A-2ik8A:
undetectable		 3ln1A-2ik8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00550
(PP-binding) 		5 LEU A  68
SER A  67
ARG A  55
ILE A  50
PHE A  54
 None
 1.47A 3ln1A-2kr5A:
undetectable		 3ln1A-2kr5A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 ARG A  90
LEU A 319
TYR A  29
ILE A  64
 None
 0.93A 3ln1A-2m56A:
undetectable		 3ln1A-2m56A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A 267
LEU A 278
ARG A 214
ILE A 217
PHE A 213
 None
 1.49A 3ln1A-2mbgA:
1.1		 3ln1A-2mbgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqa MINOR AMPULLATE
FIBROIN 1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		4 LEU A  29
SER A  30
LEU A  83
ILE A  38
 None
 0.89A 3ln1A-2mqaA:
undetectable		 3ln1A-2mqaA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvu ACTINORHODIN
POLYKETIDE SYNTHASE
ACYL CARRIER PROTEIN

(Streptomyces
coelicolor) 		PF00550
(PP-binding) 		4 LEU A  26
SER A  27
LEU A  75
ILE A  38
 None
 0.92A 3ln1A-2mvuA:
undetectable		 3ln1A-2mvuA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2

(Homo sapiens) 		PF08210
(APOBEC_N) 		4 LEU A 139
SER A 140
LEU A 108
ILE A 135
 None
 0.95A 3ln1A-2nytA:
undetectable		 3ln1A-2nytA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		5 LEU A 364
SER A 365
LEU A 302
ILE A 369
PHE A 373
 None
 1.36A 3ln1A-2o3iA:
undetectable		 3ln1A-2o3iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		4 ARG A  31
LEU A  34
LEU A 108
ILE A 126
 None
 0.79A 3ln1A-2o78A:
0.0		 3ln1A-2o78A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 LEU A 317
ARG A 526
ILE A 540
PHE A 310
 None
 0.91A 3ln1A-2obeA:
undetectable		 3ln1A-2obeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 LEU X  43
SER X  44
LEU X  97
ILE X  47
 None
 0.93A 3ln1A-2odtX:
undetectable		 3ln1A-2odtX:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogp PARTITIONING-DEFECTI
VE 3 HOMOLOG

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ARG A 109
LEU A  74
LEU A  27
ILE A  38
PHE A  36
 None
 1.43A 3ln1A-2ogpA:
undetectable		 3ln1A-2ogpA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otm HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF14588
(YjgF_endoribonc) 		4 LEU A  86
LEU A 118
ILE A  89
PHE A 123
 None
 0.83A 3ln1A-2otmA:
undetectable		 3ln1A-2otmA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 ARG A  80
LEU A  73
LEU A 167
ILE A  36
 None
 0.94A 3ln1A-2owzA:
undetectable		 3ln1A-2owzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 ARG A  76
LEU A 370
ILE A 366
PHE A 480
 None
HEM  A 500 ( 3.8A)
HEM  A 500 ( 4.1A)
None
 0.91A 3ln1A-2pg6A:
0.0		 3ln1A-2pg6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phc UNCHARACTERIZED
PROTEIN PH0987

(Pyrococcus
horikoshii) 		PF02682
(CT_C_D) 		4 LEU B  30
SER B  29
LEU B  12
ILE B  34
 None
 0.95A 3ln1A-2phcB:
undetectable		 3ln1A-2phcB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt5 SHIKIMATE KINASE

(Aquifex
aeolicus) 		PF01202
(SKI) 		4 ARG A  22
SER A  14
LEU A 158
ILE A  99
 None
 0.91A 3ln1A-2pt5A:
undetectable		 3ln1A-2pt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 LEU A  44
SER A  43
LEU A  58
PHE A  13
 None
 0.93A 3ln1A-2pyjA:
undetectable		 3ln1A-2pyjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 LEU A 389
SER A 388
LEU A 263
PHE A 393
 None
 0.94A 3ln1A-2pyjA:
undetectable		 3ln1A-2pyjA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 194
LEU A 353
ARG A 378
ILE A 382
 None
None
PO4  A2002 (-2.5A)
None
 0.87A 3ln1A-2q1fA:
undetectable		 3ln1A-2q1fA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9r PROTEIN OF UNKNOWN
FUNCTION

(Shewanella
baltica) 		PF04222
(DUF416) 		4 LEU A 164
SER A 163
ARG A  10
ILE A 168
 GOL  A 206 ( 4.9A)
GOL  A 206 (-2.9A)
None
None
 0.87A 3ln1A-2q9rA:
0.2		 3ln1A-2q9rA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 LEU B 113
SER B 111
LEU B 165
ILE B 136
 None
 0.95A 3ln1A-2qbyB:
undetectable		 3ln1A-2qbyB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  78
SER L  77
LEU L  73
TYR L  86
 None
 0.85A 3ln1A-2r4sL:
undetectable		 3ln1A-2r4sL:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		4 LEU A 269
LEU A 354
ILE A 346
PHE A 348
 None
 0.95A 3ln1A-2v95A:
undetectable		 3ln1A-2v95A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A1081
SER A1078
LEU A1215
ILE A1061
 None
 0.84A 3ln1A-2vsqA:
undetectable		 3ln1A-2vsqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 4 LEU A 218
ARG A 258
ILE A 232
PHE A 257
 None
 0.86A 3ln1A-2wb7A:
undetectable		 3ln1A-2wb7A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 SER A 272
LEU A 292
ILE A 277
PHE A 290
 None
 0.95A 3ln1A-2wyaA:
undetectable		 3ln1A-2wyaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		5 LEU A 372
SER A 359
LEU A  90
ARG A  59
ILE A 390
 None
None
None
KDM  A 500 (-2.7A)
None
 1.26A 3ln1A-2xziA:
undetectable		 3ln1A-2xziA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A 620
LEU A 365
TYR A 238
ILE A 586
 None
 0.95A 3ln1A-2xzlA:
undetectable		 3ln1A-2xzlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		4 LEU A  47
LEU A  23
ARG A 226
ILE A  45
 None
None
ZN  A 301 ( 4.2A)
None
 0.81A 3ln1A-2y7dA:
undetectable		 3ln1A-2y7dA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 177
LEU A  66
ARG A 150
ILE A 179
 None
 0.68A 3ln1A-2yp2A:
undetectable		 3ln1A-2yp2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywq RIBOSOMAL SUBUNIT
INTERFACE PROTEIN

(Thermus
thermophilus) 		PF02482
(Ribosomal_S30AE) 		4 ARG A  68
LEU A  42
LEU A  25
ILE A  13
 None
 0.69A 3ln1A-2ywqA:
undetectable		 3ln1A-2ywqA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.86A 3ln1A-2z1uA:
undetectable		 3ln1A-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 289
SER A 290
LEU A 166
ILE A 172
 None
 0.80A 3ln1A-2zauA:
undetectable		 3ln1A-2zauA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajf NON-STRUCTURAL
PROTEIN 3

(Rice hoja
blanca
tenuivirus) 		PF05310
(Tenui_NS3) 		4 LEU A  42
SER A  41
LEU A  83
ILE A  46
 None
 0.86A 3ln1A-3ajfA:
undetectable		 3ln1A-3ajfA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 4 LEU C 374
SER C 375
ARG C 420
ILE C 296
 None
 0.94A 3ln1A-3amjC:
undetectable		 3ln1A-3amjC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqs BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 LEU A 175
SER A 174
ILE A 179
PHE A 128
 None
 0.70A 3ln1A-3aqsA:
undetectable		 3ln1A-3aqsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3atb POTASSIUM
INWARDLY-RECTIFYING
CHANNEL, SUBFAMILY
J, MEMBER 6

(Mus musculus) 		PF01007
(IRK) 		4 LEU A 299
SER A 295
LEU A 243
ILE A 213
 None
 0.80A 3ln1A-3atbA:
undetectable		 3ln1A-3atbA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auw POTASSIUM
INWARDLY-RECTIFYING
CHANNEL, SUBFAMILY
J, MEMBER 6

(Mus musculus) 		PF01007
(IRK) 		4 LEU B 299
SER B 295
LEU B 243
ILE B 213
 None
 0.94A 3ln1A-3auwB:
undetectable		 3ln1A-3auwB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 281
LEU A 313
ILE A 263
PHE A 286
 None
 0.95A 3ln1A-3b2dA:
undetectable		 3ln1A-3b2dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 540
SER A 541
LEU A 574
ILE A 546
 None
 0.75A 3ln1A-3b2dA:
undetectable		 3ln1A-3b2dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 574
SER A 575
LEU A 589
ILE A 555
 None
 0.94A 3ln1A-3b2dA:
undetectable		 3ln1A-3b2dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 ARG A 181
LEU A 176
LEU A 159
ILE A 172
 None
None
5GP  A 500 ( 4.3A)
None
 0.88A 3ln1A-3b89A:
undetectable		 3ln1A-3b89A:
17.66