SIMILAR PATTERNS OF AMINO ACIDS FOR 3LM8_D_VIBD223

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		4 ASP A  68
LEU A   6
LEU A  71
ASN A  36
 None
 1.03A 3lm8B-1c3eA:
5.2
3lm8D-1c3eA:
undetectable		 3lm8B-1c3eA:
24.81
3lm8D-1c3eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 LEU A1089
LEU A1103
SER A1126
ASN A1125
 None
 1.02A 3lm8B-1e69A:
undetectable
3lm8D-1e69A:
undetectable		 3lm8B-1e69A:
23.53
3lm8D-1e69A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxo DNA-BINDING RESPONSE
REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		4 ASP A  97
LEU A 108
LEU A  76
SER A  79
 None
 0.75A 3lm8B-1nxoA:
undetectable
3lm8D-1nxoA:
2.1		 3lm8B-1nxoA:
25.35
3lm8D-1nxoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 LEU A 348
LEU A 341
SER A 243
ASN A 245
 None
 0.83A 3lm8B-1qonA:
undetectable
3lm8D-1qonA:
undetectable		 3lm8B-1qonA:
17.58
3lm8D-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		4 HIS A 187
LEU A  45
LEU A 261
SER A 174
 None
 1.01A 3lm8B-1qwkA:
undetectable
3lm8D-1qwkA:
undetectable		 3lm8B-1qwkA:
21.54
3lm8D-1qwkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		4 TYR A 161
LEU A 198
SER A 152
ASN A 153
 None
 1.04A 3lm8B-1svvA:
undetectable
3lm8D-1svvA:
undetectable		 3lm8B-1svvA:
23.90
3lm8D-1svvA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 TYR A 107
LEU A 125
LEU A 321
SER A 315
 None
None
None
SO4  A 347 (-2.6A)
 1.04A 3lm8B-1tjrA:
undetectable
3lm8D-1tjrA:
undetectable		 3lm8B-1tjrA:
20.22
3lm8D-1tjrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU D  92
LEU D 105
SER D  85
ASN D 110
 None
 1.04A 3lm8B-1u0nD:
undetectable
3lm8D-1u0nD:
undetectable		 3lm8B-1u0nD:
21.17
3lm8D-1u0nD:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASP A  34
TYR A  38
LEU A  43
LEU A  25
 None
 1.00A 3lm8B-1uliA:
undetectable
3lm8D-1uliA:
undetectable		 3lm8B-1uliA:
20.65
3lm8D-1uliA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq1 GLUTATHIONE
S-TRANSFERASE

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A 159
LEU A 166
LEU A 186
SER A 192
ASN A 191
 None
 1.45A 3lm8B-1yq1A:
undetectable
3lm8D-1yq1A:
undetectable		 3lm8B-1yq1A:
20.69
3lm8D-1yq1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		4 HIS A  63
LEU A  96
LEU A 263
CYH A 302
 None
 1.04A 3lm8B-1z7dA:
undetectable
3lm8D-1z7dA:
undetectable		 3lm8B-1z7dA:
19.72
3lm8D-1z7dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Staphylococcus
aureus) 		PF00475
(IGPD) 		4 ASP A  20
LEU A  76
LEU A  47
SER A  17
 None
 1.01A 3lm8B-2ae8A:
undetectable
3lm8D-2ae8A:
undetectable		 3lm8B-2ae8A:
19.11
3lm8D-2ae8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 ASP A 138
HIS A  74
LEU A 186
LEU A 135
 None
 0.96A 3lm8B-2azkA:
undetectable
3lm8D-2azkA:
undetectable		 3lm8B-2azkA:
21.52
3lm8D-2azkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		4 LEU A  85
LEU A 116
CYH A  80
SER A  82
 None
 0.94A 3lm8B-2gtiA:
undetectable
3lm8D-2gtiA:
undetectable		 3lm8B-2gtiA:
19.95
3lm8D-2gtiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
XYQ  A1222 (-3.3A)
 0.77A 3lm8B-2hjhA:
2.8
3lm8D-2hjhA:
undetectable		 3lm8B-2hjhA:
20.45
3lm8D-2hjhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00072
(Response_reg) 		4 ASP A  93
LEU A 105
LEU A  72
SER A  75
 None
 0.86A 3lm8B-2hqoA:
2.4
3lm8D-2hqoA:
2.1		 3lm8B-2hqoA:
17.84
3lm8D-2hqoA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msv MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		no annotation 4 TYR A  23
LEU A  97
LEU A  89
SER A  83
 None
 1.01A 3lm8B-2msvA:
undetectable
3lm8D-2msvA:
undetectable		 3lm8B-2msvA:
20.18
3lm8D-2msvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		4 ASP A  80
LEU A  93
LEU A  72
SER A  46
 None
 0.84A 3lm8B-2o2gA:
3.7
3lm8D-2o2gA:
undetectable		 3lm8B-2o2gA:
20.60
3lm8D-2o2gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 LEU B 203
LEU B 189
SER B 192
ASN B 219
 None
 1.01A 3lm8B-2p1nB:
undetectable
3lm8D-2p1nB:
undetectable		 3lm8B-2p1nB:
14.81
3lm8D-2p1nB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF10585
(UBA_e1_thiolCys) 		4 ASP A 353
LEU A 313
LEU A 321
ASN A 360
 None
 0.91A 3lm8B-2px9A:
undetectable
3lm8D-2px9A:
undetectable		 3lm8B-2px9A:
21.54
3lm8D-2px9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 LEU A 276
LEU A 278
SER A 344
ASN A 346
 None
 1.02A 3lm8B-2vhlA:
undetectable
3lm8D-2vhlA:
undetectable		 3lm8B-2vhlA:
20.25
3lm8D-2vhlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 427
HIS A 333
LEU A 440
LEU A 424
 None
 0.94A 3lm8B-2vqdA:
3.3
3lm8D-2vqdA:
3.9		 3lm8B-2vqdA:
20.73
3lm8D-2vqdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ASP A 494
HIS A 505
LEU A 549
SER A 542
 None
 0.93A 3lm8B-2vxoA:
2.1
3lm8D-2vxoA:
2.3		 3lm8B-2vxoA:
14.49
3lm8D-2vxoA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		4 ASP A  57
LEU A 338
SER A  62
ASN A  64
 None
 0.88A 3lm8B-2w6dA:
undetectable
3lm8D-2w6dA:
undetectable		 3lm8B-2w6dA:
15.88
3lm8D-2w6dA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ASP A 251
HIS A 301
LEU A 219
CYH A 294
 None
 0.86A 3lm8B-2wpgA:
2.8
3lm8D-2wpgA:
3.0		 3lm8B-2wpgA:
15.54
3lm8D-2wpgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		4 ASP A  88
LEU A  67
LEU A  91
SER A 307
 None
 0.94A 3lm8B-2wyrA:
undetectable
3lm8D-2wyrA:
undetectable		 3lm8B-2wyrA:
21.59
3lm8D-2wyrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 LEU A  40
LEU A 191
CYH A 195
SER A 197
 None
 1.01A 3lm8B-2xhyA:
undetectable
3lm8D-2xhyA:
1.3		 3lm8B-2xhyA:
18.18
3lm8D-2xhyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 377
LEU A 392
SER A 395
ASN A 397
 None
None
NAG  A 811 ( 4.1A)
None
 0.98A 3lm8B-2z81A:
undetectable
3lm8D-2z81A:
undetectable		 3lm8B-2z81A:
18.74
3lm8D-2z81A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 LEU A 282
LEU A 204
CYH A 173
ASN A 174
 None
 1.03A 3lm8B-2z87A:
2.2
3lm8D-2z87A:
undetectable		 3lm8B-2z87A:
17.52
3lm8D-2z87A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		4 HIS A  38
TYR A 191
LEU A 274
SER A 187
 PAJ  A 501 (-4.2A)
None
None
None
 0.91A 3lm8B-3ag6A:
undetectable
3lm8D-3ag6A:
2.3		 3lm8B-3ag6A:
23.02
3lm8D-3ag6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 ASP A 294
LEU A 271
LEU A 265
SER A 297
 None
 0.96A 3lm8B-3agrA:
undetectable
3lm8D-3agrA:
undetectable		 3lm8B-3agrA:
16.89
3lm8D-3agrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 226
LEU A 236
SER A 239
ASN A 241
 None
 1.00A 3lm8B-3bz5A:
undetectable
3lm8D-3bz5A:
undetectable		 3lm8B-3bz5A:
16.70
3lm8D-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 353
LEU A 363
SER A 366
ASN A 368
 None
 1.00A 3lm8B-3bz5A:
undetectable
3lm8D-3bz5A:
undetectable		 3lm8B-3bz5A:
16.70
3lm8D-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8j NATURAL KILLER CELL
RECEPTOR LY49C

(Mus musculus) 		PF00059
(Lectin_C)
PF08391
(Ly49) 		4 TYR A 195
LEU A 175
LEU A 186
SER A 236
 None
 1.02A 3lm8B-3c8jA:
undetectable
3lm8D-3c8jA:
undetectable		 3lm8B-3c8jA:
18.80
3lm8D-3c8jA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 TYR A 174
LEU A 169
SER A 189
ASN A 190
 None
 0.95A 3lm8B-3cq9A:
23.9
3lm8D-3cq9A:
22.3		 3lm8B-3cq9A:
41.35
3lm8D-3cq9A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 TYR A 174
LEU A 176
SER A 189
ASN A 190
 None
 0.41A 3lm8B-3cq9A:
23.9
3lm8D-3cq9A:
22.3		 3lm8B-3cq9A:
41.35
3lm8D-3cq9A:
41.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crj TRANSCRIPTION
REGULATOR

(Haloarcula
marismortui) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 HIS A 155
LEU A  93
LEU A 135
SER A 159
 None
 1.02A 3lm8B-3crjA:
undetectable
3lm8D-3crjA:
undetectable		 3lm8B-3crjA:
24.02
3lm8D-3crjA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 ASP A 250
HIS A 300
LEU A 218
CYH A 293
 None
 0.84A 3lm8B-3czeA:
2.1
3lm8D-3czeA:
2.2		 3lm8B-3czeA:
15.10
3lm8D-3czeA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 HIS A 230
LEU A 327
SER A 234
ASN A 236
 None
 0.82A 3lm8B-3e7gA:
undetectable
3lm8D-3e7gA:
undetectable		 3lm8B-3e7gA:
18.34
3lm8D-3e7gA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASP A  32
TYR A  36
LEU A  41
LEU A  23
 None
 0.85A 3lm8B-3eqqA:
undetectable
3lm8D-3eqqA:
undetectable		 3lm8B-3eqqA:
20.75
3lm8D-3eqqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffv PROTEIN SYD

(Escherichia
coli) 		PF07348
(Syd) 		4 HIS A 119
LEU A 177
LEU A  98
SER A 145
 None
 0.97A 3lm8B-3ffvA:
undetectable
3lm8D-3ffvA:
undetectable		 3lm8B-3ffvA:
23.01
3lm8D-3ffvA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8k LECTIN-RELATED NK
CELL RECEPTOR LY49L1

(Mus musculus) 		PF00059
(Lectin_C) 		4 TYR A 198
LEU A 178
LEU A 189
SER A 239
 None
 0.94A 3lm8B-3g8kA:
undetectable
3lm8D-3g8kA:
undetectable		 3lm8B-3g8kA:
19.72
3lm8D-3g8kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8l LECTIN-RELATED NK
CELL RECEPTOR LY49L1

(Mus musculus) 		PF00059
(Lectin_C)
PF08391
(Ly49) 		4 TYR A 198
LEU A 178
LEU A 189
SER A 239
 None
 0.78A 3lm8B-3g8lA:
undetectable
3lm8D-3g8lA:
undetectable		 3lm8B-3g8lA:
22.13
3lm8D-3g8lA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASP A  36
TYR A  40
LEU A  45
LEU A  27
 None
 1.03A 3lm8B-3gzyA:
undetectable
3lm8D-3gzyA:
undetectable		 3lm8B-3gzyA:
21.04
3lm8D-3gzyA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ihk THIAMIN
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 169
LEU A 171
SER A 184
ASN A 185
 None
 0.71A 3lm8B-3ihkA:
21.4
3lm8D-3ihkA:
10.8		 3lm8B-3ihkA:
34.35
3lm8D-3ihkA:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqj MLL1 PHD3-BROMO

(Homo sapiens) 		PF00628
(PHD) 		4 HIS A1628
TYR A1619
LEU A1613
LEU A1636
 None
 1.01A 3lm8B-3lqjA:
undetectable
3lm8D-3lqjA:
undetectable		 3lm8B-3lqjA:
19.92
3lm8D-3lqjA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mel THIAMIN
PYROPHOSPHOKINASE
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 174
LEU A 176
SER A 189
ASN A 190
 None
 0.54A 3lm8B-3melA:
24.6
3lm8D-3melA:
24.0		 3lm8B-3melA:
38.16
3lm8D-3melA:
38.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp2 NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF08715
(Viral_protease) 		4 HIS A 183
TYR A  39
LEU A  41
CYH A  37
 None
 1.04A 3lm8B-3mp2A:
undetectable
3lm8D-3mp2A:
undetectable		 3lm8B-3mp2A:
18.47
3lm8D-3mp2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE

(Homo sapiens) 		PF05577
(Peptidase_S28) 		4 ASP B  95
HIS B 456
LEU B  73
CYH B 100
 NAG  B   1 ( 4.6A)
None
None
None
 0.96A 3lm8B-3n2zB:
undetectable
3lm8D-3n2zB:
undetectable		 3lm8B-3n2zB:
19.69
3lm8D-3n2zB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmb PUTATIVE SUGAR
HYDROLASE

(Bacteroides
ovatus) 		PF06439
(DUF1080) 		4 LEU A 230
LEU A 138
CYH A 259
ASN A 258
 None
 1.01A 3lm8B-3nmbA:
undetectable
3lm8D-3nmbA:
undetectable		 3lm8B-3nmbA:
24.46
3lm8D-3nmbA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 ASP A 206
LEU A 160
LEU A 231
SER A 177
 None
 0.89A 3lm8B-3p40A:
undetectable
3lm8D-3p40A:
undetectable		 3lm8B-3p40A:
19.40
3lm8D-3p40A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		4 HIS A  37
TYR A 192
LEU A 274
SER A 188
 AMP  A 501 (-4.1A)
None
None
AMP  A 501 ( 4.9A)
 0.91A 3lm8B-3q10A:
undetectable
3lm8D-3q10A:
undetectable		 3lm8B-3q10A:
22.18
3lm8D-3q10A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 672
LEU A 501
CYH A 594
SER A 592
 None
 0.93A 3lm8B-3ttfA:
2.6
3lm8D-3ttfA:
undetectable		 3lm8B-3ttfA:
14.57
3lm8D-3ttfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		4 HIS A 869
LEU A 936
LEU A 914
SER A 907
 None
 1.03A 3lm8B-3un9A:
undetectable
3lm8D-3un9A:
2.6		 3lm8B-3un9A:
20.63
3lm8D-3un9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uy4 PANTOTHENATE
SYNTHETASE

(Campylobacter
jejuni) 		PF02569
(Pantoate_ligase) 		4 HIS A  37
TYR A 189
LEU A 272
SER A 185
 AMP  A 301 (-3.9A)
None
None
AMP  A 301 ( 4.9A)
 0.90A 3lm8B-3uy4A:
2.4
3lm8D-3uy4A:
undetectable		 3lm8B-3uy4A:
22.90
3lm8D-3uy4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 690
LEU A 730
SER A 708
ASN A 709
 None
 0.90A 3lm8B-3wpeA:
undetectable
3lm8D-3wpeA:
undetectable		 3lm8B-3wpeA:
13.78
3lm8D-3wpeA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		4 LEU A 307
LEU A 276
CYH A 333
SER A 335
 None
 0.99A 3lm8B-3zdpA:
undetectable
3lm8D-3zdpA:
undetectable		 3lm8B-3zdpA:
16.70
3lm8D-3zdpA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 ASP A  34
LEU A 192
LEU A  33
ASN A 259
 None
 0.91A 3lm8B-4cczA:
undetectable
3lm8D-4cczA:
undetectable		 3lm8B-4cczA:
17.67
3lm8D-4cczA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE

(Pseudomonas
aeruginosa) 		PF04199
(Cyclase) 		4 LEU A 109
LEU A 187
CYH A  80
SER A 106
 None
 0.84A 3lm8B-4cobA:
undetectable
3lm8D-4cobA:
undetectable		 3lm8B-4cobA:
21.37
3lm8D-4cobA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		4 HIS A 315
LEU A 143
SER A 268
ASN A 241
 None
AW2  A 502 ( 4.4A)
None
AW2  A 502 (-4.3A)
 0.95A 3lm8B-4er6A:
2.4
3lm8D-4er6A:
2.2		 3lm8B-4er6A:
17.51
3lm8D-4er6A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASP A 495
HIS A  44
LEU A 441
SER A 473
 None
 1.02A 3lm8B-4fffA:
2.4
3lm8D-4fffA:
2.4		 3lm8B-4fffA:
18.13
3lm8D-4fffA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 ASP A 115
LEU A  38
LEU A  95
CYH A  50
SER A  48
 None
 1.37A 3lm8B-4fzwA:
2.5
3lm8D-4fzwA:
undetectable		 3lm8B-4fzwA:
22.71
3lm8D-4fzwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Chaetomium
thermophilum;
Humicola
insolens;
Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 ASP A 118
HIS A 109
LEU A 447
LEU A 121
SER A 126
 None
 1.34A 3lm8B-4i5uA:
undetectable
3lm8D-4i5uA:
undetectable		 3lm8B-4i5uA:
19.78
3lm8D-4i5uA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i86 CELLULOSE SYNTHASE 1

(Komagataeibacter
xylinus) 		PF07238
(PilZ) 		4 ASP A  60
LEU A 100
LEU A  59
SER A  92
 None
 1.00A 3lm8B-4i86A:
undetectable
3lm8D-4i86A:
undetectable		 3lm8B-4i86A:
21.65
3lm8D-4i86A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
APR  A 602 (-3.2A)
 0.76A 3lm8B-4iaoA:
3.0
3lm8D-4iaoA:
2.9		 3lm8B-4iaoA:
18.62
3lm8D-4iaoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASP A1426
HIS A1334
LEU A1385
LEU A1425
 None
 0.91A 3lm8B-4iglA:
undetectable
3lm8D-4iglA:
undetectable		 3lm8B-4iglA:
9.42
3lm8D-4iglA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN

(Pseudomonas
aeruginosa;
Vibrio cholerae) 		PF00437
(T2SSE)
PF05638
(T6SS_HCP) 		4 HIS A 459
LEU A 261
LEU A 370
SER A 381
 None
 0.96A 3lm8B-4kssA:
1.4
3lm8D-4kssA:
2.0		 3lm8B-4kssA:
17.70
3lm8D-4kssA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 LEU A  75
LEU A 113
SER A  91
ASN A  92
 None
 1.04A 3lm8B-4p8sA:
undetectable
3lm8D-4p8sA:
undetectable		 3lm8B-4p8sA:
20.42
3lm8D-4p8sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		4 HIS A 455
LEU A 257
LEU A 366
SER A 377
 None
 0.97A 3lm8B-4phtA:
2.9
3lm8D-4phtA:
3.1		 3lm8B-4phtA:
18.47
3lm8D-4phtA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 ASP A 187
TYR A  15
LEU A  11
ASN A  49
 None
 0.83A 3lm8B-4tx1A:
3.1
3lm8D-4tx1A:
2.7		 3lm8B-4tx1A:
21.16
3lm8D-4tx1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 HIS A 118
LEU A  56
LEU A  69
ASN A  74
 None
 0.98A 3lm8B-4u09A:
undetectable
3lm8D-4u09A:
undetectable		 3lm8B-4u09A:
18.81
3lm8D-4u09A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 ASP A 253
HIS A 170
LEU A 181
LEU A 234
 None
 0.99A 3lm8B-4ud4A:
undetectable
3lm8D-4ud4A:
undetectable		 3lm8B-4ud4A:
20.27
3lm8D-4ud4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		4 ASP A1021
LEU A1017
CYH A1004
SER A 784
 None
None
U  C   4 ( 4.2A)
None
 1.00A 3lm8B-4zlrA:
undetectable
3lm8D-4zlrA:
undetectable		 3lm8B-4zlrA:
19.66
3lm8D-4zlrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 ASP A 277
HIS A 348
LEU A 154
LEU A 274
 None
ZN  A 402 (-3.3A)
None
None
 1.04A 3lm8B-4zr1A:
undetectable
3lm8D-4zr1A:
undetectable		 3lm8B-4zr1A:
20.13
3lm8D-4zr1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1413
LEU A1585
SER A1579
ASN A1578
 None
 0.97A 3lm8B-5a31A:
undetectable
3lm8D-5a31A:
undetectable		 3lm8B-5a31A:
9.85
3lm8D-5a31A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 HIS A 297
LEU A 762
LEU A 850
SER A 826
 None
 0.99A 3lm8B-5a42A:
5.3
3lm8D-5a42A:
5.3		 3lm8B-5a42A:
8.48
3lm8D-5a42A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9t PUTATIVE
DEHYDROGENASE

(Amycolatopsis
orientalis) 		PF03446
(NAD_binding_2) 		4 ASP A  73
TYR A  76
LEU A  79
LEU A  69
 None
 0.90A 3lm8B-5a9tA:
2.4
3lm8D-5a9tA:
3.0		 3lm8B-5a9tA:
21.36
3lm8D-5a9tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASP A  36
TYR A  40
LEU A  45
LEU A  27
 None
 1.00A 3lm8B-5aewA:
undetectable
3lm8D-5aewA:
undetectable		 3lm8B-5aewA:
18.95
3lm8D-5aewA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		4 ASP C 590
TYR C 595
LEU C 597
LEU C 585
 None
 0.98A 3lm8B-5d9aC:
undetectable
3lm8D-5d9aC:
undetectable		 3lm8B-5d9aC:
13.81
3lm8D-5d9aC:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhm IMMUNOREACTIVE 32
KDA ANTIGEN

(Porphyromonas
gingivalis) 		no annotation 4 LEU C 266
LEU C 205
SER C 251
ASN C 253
 None
 1.04A 3lm8B-5dhmC:
undetectable
3lm8D-5dhmC:
undetectable		 3lm8B-5dhmC:
21.05
3lm8D-5dhmC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU A 332
LEU A 344
CYH A 335
SER A 337
 None
 0.96A 3lm8B-5flzA:
undetectable
3lm8D-5flzA:
undetectable		 3lm8B-5flzA:
13.37
3lm8D-5flzA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		4 HIS A 231
LEU A 132
LEU A  54
SER A 109
 None
 0.98A 3lm8B-5hftA:
undetectable
3lm8D-5hftA:
undetectable		 3lm8B-5hftA:
18.03
3lm8D-5hftA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxt (2Z,6Z)-FARNESYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Solanum
habrochaites) 		PF01255
(Prenyltransf) 		4 HIS A 194
LEU A 176
LEU A 199
SER A 164
 None
 1.01A 3lm8B-5hxtA:
undetectable
3lm8D-5hxtA:
undetectable		 3lm8B-5hxtA:
24.62
3lm8D-5hxtA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 HIS A1119
LEU A1084
LEU A1135
CYH A1070
 None
 0.99A 3lm8B-5ja1A:
undetectable
3lm8D-5ja1A:
undetectable		 3lm8B-5ja1A:
9.87
3lm8D-5ja1A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF11976
(Rad60-SLD)
PF14324
(PINIT) 		4 ASP A 520
LEU A 478
LEU A 459
SER A 462
 None
 1.04A 3lm8B-5jneA:
3.2
3lm8D-5jneA:
3.3		 3lm8B-5jneA:
22.22
3lm8D-5jneA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 0.83A 3lm8B-5ko3A:
undetectable
3lm8D-5ko3A:
undetectable		 3lm8B-5ko3A:
19.93
3lm8D-5ko3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 HIS A  47
LEU A 216
LEU A 243
SER A 246
 None
 1.04A 3lm8B-5lt9A:
undetectable
3lm8D-5lt9A:
undetectable		 3lm8B-5lt9A:
22.77
3lm8D-5lt9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 ASP A 256
HIS A 306
LEU A 225
CYH A 299
 None
 0.91A 3lm8B-5n6vA:
undetectable
3lm8D-5n6vA:
3.2		 3lm8B-5n6vA:
15.69
3lm8D-5n6vA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		4 HIS A 203
LEU A 269
LEU A 277
ASN A 361
 None
 1.02A 3lm8B-5nv6A:
undetectable
3lm8D-5nv6A:
undetectable		 3lm8B-5nv6A:
15.57
3lm8D-5nv6A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 ASP A 333
LEU A  18
LEU A 361
SER A 354
 None
 0.96A 3lm8B-5ux5A:
3.6
3lm8D-5ux5A:
2.7		 3lm8B-5ux5A:
12.30
3lm8D-5ux5A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN

(Vibrio
vulnificus) 		no annotation 4 ASP A3838
LEU A3825
LEU A3837
SER A3832
 ASP  A3838 ( 0.6A)
LEU  A3825 ( 0.6A)
LEU  A3837 ( 0.5A)
SER  A3832 ( 0.0A)
 0.93A 3lm8B-5w6lA:
undetectable
3lm8D-5w6lA:
undetectable		 3lm8B-5w6lA:
21.31
3lm8D-5w6lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 1.00A 3lm8B-5w8uA:
undetectable
3lm8D-5w8uA:
undetectable		 3lm8B-5w8uA:
19.14
3lm8D-5w8uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x06 DNAA REGULATORY
INACTIVATOR HDA

(Escherichia
coli) 		no annotation 4 LEU E  48
LEU E  34
SER E  28
ASN E  27
 None
 0.96A 3lm8B-5x06E:
undetectable
3lm8D-5x06E:
undetectable		 3lm8B-5x06E:
15.35
3lm8D-5x06E:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Komagataella
phaffii) 		PF06093
(Spt4) 		4 LEU V  36
LEU V  90
CYH V  49
SER V  51
 None
 0.75A 3lm8B-5xonV:
undetectable
3lm8D-5xonV:
undetectable		 3lm8B-5xonV:
17.76
3lm8D-5xonV:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 LEU A 693
LEU A 733
SER A 711
ASN A 712
 None
None
NAG  A 914 ( 4.1A)
None
 1.02A 3lm8B-5zlnA:
undetectable
3lm8D-5zlnA:
undetectable		 3lm8B-5zlnA:
17.05
3lm8D-5zlnA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 LEU A 415
LEU A 307
CYH A 286
SER A 264
 None
 0.99A 3lm8B-6a8mA:
3.6
3lm8D-6a8mA:
undetectable		 3lm8B-6a8mA:
undetectable
3lm8D-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 4 ASP A  97
HIS A  43
TYR A 100
SER A 137
 None
 0.90A 3lm8B-6emsA:
undetectable
3lm8D-6emsA:
undetectable		 3lm8B-6emsA:
14.88
3lm8D-6emsA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 TYR A1351
LEU A1350
LEU A1830
CYH A1354
 None
 0.76A 3lm8B-6ez8A:
undetectable
3lm8D-6ez8A:
undetectable		 3lm8B-6ez8A:
11.52
3lm8D-6ez8A:
11.52