SIMILAR PATTERNS OF AMINO ACIDS FOR 3LM8_C_VIBC223_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 TYR 3  67
LEU 2 123
LEU 2 168
SER 2 163
 None
 0.99A 3lm8A-1bev3:
2.3
3lm8C-1bev3:
3.2		 3lm8A-1bev3:
21.40
3lm8C-1bev3:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		4 ASP A  68
LEU A   6
LEU A  71
ASN A  36
 None
 0.90A 3lm8A-1c3eA:
4.9
3lm8C-1c3eA:
5.4		 3lm8A-1c3eA:
24.81
3lm8C-1c3eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 LEU A1089
LEU A1103
SER A1126
ASN A1125
 None
 1.02A 3lm8A-1e69A:
undetectable
3lm8C-1e69A:
undetectable		 3lm8A-1e69A:
23.53
3lm8C-1e69A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et6 SUPERANTIGEN SMEZ-2

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR A 154
LEU A 174
LEU A 141
SER A 149
 None
 0.96A 3lm8A-1et6A:
undetectable
3lm8C-1et6A:
undetectable		 3lm8A-1et6A:
19.92
3lm8C-1et6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		4 ASP 1 220
LEU 1 307
LEU 1 170
SER 1 167
 None
 0.91A 3lm8A-1g6q1:
undetectable
3lm8C-1g6q1:
undetectable		 3lm8A-1g6q1:
20.48
3lm8C-1g6q1:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LYS A 293
ASP A 297
LEU A 192
LEU A 300
 None
 0.99A 3lm8A-1jswA:
undetectable
3lm8C-1jswA:
undetectable		 3lm8A-1jswA:
18.34
3lm8C-1jswA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ASP B 480
LEU B 512
LEU B 457
SER B 477
 None
 0.95A 3lm8A-1m2vB:
3.1
3lm8C-1m2vB:
undetectable		 3lm8A-1m2vB:
13.42
3lm8C-1m2vB:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		4 ASP A 180
TYR A 201
LEU A 203
LEU A 184
 None
 0.98A 3lm8A-1m9iA:
undetectable
3lm8C-1m9iA:
undetectable		 3lm8A-1m9iA:
15.36
3lm8C-1m9iA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw2 THIOREDOXIN

(Alicyclobacillus
acidocaldarius) 		PF00085
(Thioredoxin) 		4 LYS A  54
ASP A  23
LEU A  96
LEU A  75
 None
 0.91A 3lm8A-1nw2A:
undetectable
3lm8C-1nw2A:
undetectable		 3lm8A-1nw2A:
18.98
3lm8C-1nw2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxo DNA-BINDING RESPONSE
REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		4 ASP A  97
LEU A 108
LEU A  76
SER A  79
 None
 0.90A 3lm8A-1nxoA:
2.7
3lm8C-1nxoA:
2.9		 3lm8A-1nxoA:
25.35
3lm8C-1nxoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaz THIOREDOXIN 1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		4 LYS A  71
ASP A  26
LEU A 113
LEU A  92
 None
 0.96A 3lm8A-1oazA:
undetectable
3lm8C-1oazA:
undetectable		 3lm8A-1oazA:
24.07
3lm8C-1oazA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 203
LEU A 361
LEU A 351
ASN A 210
 None
 0.99A 3lm8A-1pxtA:
undetectable
3lm8C-1pxtA:
undetectable		 3lm8A-1pxtA:
20.81
3lm8C-1pxtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 LEU A 348
LEU A 341
SER A 243
ASN A 245
 None
 0.97A 3lm8A-1qonA:
undetectable
3lm8C-1qonA:
undetectable		 3lm8A-1qonA:
17.58
3lm8C-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri9 FYN-BINDING PROTEIN

(Homo sapiens) 		PF14603
(hSH3) 		4 TYR A  73
LEU A  45
LEU A  53
CYH A  66
 None
 1.01A 3lm8A-1ri9A:
undetectable
3lm8C-1ri9A:
undetectable		 3lm8A-1ri9A:
18.14
3lm8C-1ri9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2) 		4 ASP A 115
TYR A 105
LEU A 103
LEU A 118
 None
 0.96A 3lm8A-1s1gA:
undetectable
3lm8C-1s1gA:
undetectable		 3lm8A-1s1gA:
18.61
3lm8C-1s1gA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		4 LEU A  78
LEU A 101
SER A 126
ASN A 104
 None
None
SAM  A1501 ( 2.4A)
SF4  A1401 ( 4.4A)
 0.94A 3lm8A-1tv8A:
undetectable
3lm8C-1tv8A:
2.0		 3lm8A-1tv8A:
22.66
3lm8C-1tv8A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Deinococcus
radiodurans) 		PF02566
(OsmC) 		4 LEU B  49
LEU B  28
SER B  31
ASN B  45
 None
 0.83A 3lm8A-1uspB:
undetectable
3lm8C-1uspB:
undetectable		 3lm8A-1uspB:
19.09
3lm8C-1uspB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		4 ASP A 127
TYR A 154
LEU A 156
LEU A 125
 None
 1.02A 3lm8A-1w6fA:
undetectable
3lm8C-1w6fA:
undetectable		 3lm8A-1w6fA:
21.43
3lm8C-1w6fA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq1 GLUTATHIONE
S-TRANSFERASE

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A 159
LEU A 166
LEU A 186
SER A 192
ASN A 191
 None
 1.42A 3lm8A-1yq1A:
undetectable
3lm8C-1yq1A:
undetectable		 3lm8A-1yq1A:
20.69
3lm8C-1yq1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2k NATURAL KILLER CELL
RECEPTOR 2B4

(Mus musculus) 		PF11465
(Receptor_2B4) 		4 ASP A  83
TYR A  65
LEU A  19
LEU A 105
 None
 1.02A 3lm8A-1z2kA:
undetectable
3lm8C-1z2kA:
undetectable		 3lm8A-1z2kA:
19.55
3lm8C-1z2kA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		4 ASP A 116
LEU A  96
CYH A 122
ASN A  92
 SAM  A 301 (-3.0A)
None
None
None
 1.03A 3lm8A-2br4A:
undetectable
3lm8C-2br4A:
undetectable		 3lm8A-2br4A:
18.80
3lm8C-2br4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 ASP A 250
LEU A 287
LEU A 247
SER A 299
 None
None
None
CD  A 701 ( 4.9A)
 0.92A 3lm8A-2ffhA:
undetectable
3lm8C-2ffhA:
undetectable		 3lm8A-2ffhA:
20.00
3lm8C-2ffhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		4 LEU A  85
LEU A 116
CYH A  80
SER A  82
 None
 0.89A 3lm8A-2gtiA:
undetectable
3lm8C-2gtiA:
undetectable		 3lm8A-2gtiA:
19.95
3lm8C-2gtiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
XYQ  A1222 (-3.3A)
 0.89A 3lm8A-2hjhA:
2.8
3lm8C-2hjhA:
2.3		 3lm8A-2hjhA:
20.45
3lm8C-2hjhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqr PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ASP A  93
LEU A 105
LEU A  72
SER A  75
 None
 0.92A 3lm8A-2hqrA:
undetectable
3lm8C-2hqrA:
2.4		 3lm8A-2hqrA:
21.95
3lm8C-2hqrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4a THIOREDOXIN

(Acetobacter
aceti) 		PF00085
(Thioredoxin) 		4 LYS A  57
ASP A  26
LEU A  99
LEU A  78
 BME  A1001 (-2.9A)
None
None
None
 1.00A 3lm8A-2i4aA:
undetectable
3lm8C-2i4aA:
undetectable		 3lm8A-2i4aA:
17.57
3lm8C-2i4aA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipa THIOREDOXIN

(Bacillus
subtilis) 		PF00085
(Thioredoxin) 		4 LYS A  54
ASP A  23
LEU A  42
LEU A  21
 None
 0.99A 3lm8A-2ipaA:
undetectable
3lm8C-2ipaA:
undetectable		 3lm8A-2ipaA:
19.82
3lm8C-2ipaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7e DNA DAMAGE-INDUCIBLE
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 169
LEU A 128
LEU A 103
SER A 106
 None
 1.00A 3lm8A-2n7eA:
undetectable
3lm8C-2n7eA:
undetectable		 3lm8A-2n7eA:
23.11
3lm8C-2n7eA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz0 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2)
PF11601
(Shal-type) 		4 ASP B 115
TYR B 105
LEU B 103
LEU B 118
 None
 0.98A 3lm8A-2nz0B:
undetectable
3lm8C-2nz0B:
undetectable		 3lm8A-2nz0B:
16.96
3lm8C-2nz0B:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		4 ASP A  80
LEU A  93
LEU A  72
SER A  46
 None
 0.93A 3lm8A-2o2gA:
2.4
3lm8C-2o2gA:
undetectable		 3lm8A-2o2gA:
20.60
3lm8C-2o2gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohw YUEI PROTEIN

(Bacillus
subtilis) 		PF07997
(DUF1694) 		4 LYS A   3
ASP A   7
LEU A  27
LEU A  10
 None
 0.96A 3lm8A-2ohwA:
undetectable
3lm8C-2ohwA:
undetectable		 3lm8A-2ohwA:
19.63
3lm8C-2ohwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8q IRON-REGULATED
SURFACE DETERMINANT
E

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		4 LYS A 278
ASP A 277
LEU A 149
ASN A 273
 None
 0.96A 3lm8A-2q8qA:
3.7
3lm8C-2q8qA:
3.2		 3lm8A-2q8qA:
20.66
3lm8C-2q8qA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhs CATHSILICATEIN

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 ASP A 109
LEU A  53
LEU A  34
SER A 105
 None
 0.88A 3lm8A-2vhsA:
undetectable
3lm8C-2vhsA:
undetectable		 3lm8A-2vhsA:
18.30
3lm8C-2vhsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		4 LYS A  75
TYR A 102
LEU A 104
LEU A  40
 None
 0.88A 3lm8A-2xfsA:
undetectable
3lm8C-2xfsA:
undetectable		 3lm8A-2xfsA:
17.69
3lm8C-2xfsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3

(Mus musculus) 		PF00621
(RhoGEF) 		4 LYS A  35
ASP A  40
LEU A  43
ASN A  54
 None
 0.97A 3lm8A-2z0qA:
undetectable
3lm8C-2z0qA:
undetectable		 3lm8A-2z0qA:
21.51
3lm8C-2z0qA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 LEU A 282
LEU A 204
CYH A 173
ASN A 174
 None
 1.00A 3lm8A-2z87A:
undetectable
3lm8C-2z87A:
2.7		 3lm8A-2z87A:
17.52
3lm8C-2z87A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 ASP A 294
LEU A 271
LEU A 265
SER A 297
 None
 0.92A 3lm8A-3agrA:
undetectable
3lm8C-3agrA:
undetectable		 3lm8A-3agrA:
16.89
3lm8C-3agrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 120
LEU A 130
SER A 133
ASN A 135
 None
 0.96A 3lm8A-3bz5A:
undetectable
3lm8C-3bz5A:
undetectable		 3lm8A-3bz5A:
16.70
3lm8C-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 162
LEU A 172
SER A 175
ASN A 177
 None
 0.93A 3lm8A-3bz5A:
undetectable
3lm8C-3bz5A:
undetectable		 3lm8A-3bz5A:
16.70
3lm8C-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 226
LEU A 236
SER A 239
ASN A 241
 None
 0.89A 3lm8A-3bz5A:
undetectable
3lm8C-3bz5A:
undetectable		 3lm8A-3bz5A:
16.70
3lm8C-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 353
LEU A 363
SER A 366
ASN A 368
 None
 0.81A 3lm8A-3bz5A:
undetectable
3lm8C-3bz5A:
undetectable		 3lm8A-3bz5A:
16.70
3lm8C-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		4 LEU A 284
LEU A 225
CYH A 227
SER A 229
 None
 0.97A 3lm8A-3c0kA:
2.4
3lm8C-3c0kA:
2.4		 3lm8A-3c0kA:
18.00
3lm8C-3c0kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ASP A 106
LEU A  62
LEU A 104
SER A 120
 None
 0.92A 3lm8A-3c8eA:
undetectable
3lm8C-3c8eA:
undetectable		 3lm8A-3c8eA:
24.17
3lm8C-3c8eA:
24.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 TYR A 174
LEU A 169
SER A 189
ASN A 190
 None
 0.99A 3lm8A-3cq9A:
23.8
3lm8C-3cq9A:
23.3		 3lm8A-3cq9A:
41.35
3lm8C-3cq9A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 TYR A 174
LEU A 176
SER A 189
ASN A 190
 None
 0.58A 3lm8A-3cq9A:
23.8
3lm8C-3cq9A:
23.3		 3lm8A-3cq9A:
41.35
3lm8C-3cq9A:
41.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eod PROTEIN HNR

(Escherichia
coli) 		PF00072
(Response_reg) 		4 ASP A 104
LEU A 116
LEU A  83
SER A  86
 None
 0.88A 3lm8A-3eodA:
2.3
3lm8C-3eodA:
undetectable		 3lm8A-3eodA:
22.33
3lm8C-3eodA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 TYR A  44
LEU A  51
LEU A  30
SER A  40
 None
 0.69A 3lm8A-3fiwA:
undetectable
3lm8C-3fiwA:
undetectable		 3lm8A-3fiwA:
21.67
3lm8C-3fiwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i07 ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Vibrio cholerae) 		PF02566
(OsmC) 		4 LEU A  53
LEU A  33
SER A  36
ASN A  49
 None
 0.85A 3lm8A-3i07A:
undetectable
3lm8C-3i07A:
undetectable		 3lm8A-3i07A:
21.05
3lm8C-3i07A:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ihk THIAMIN
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 169
LEU A 171
SER A 184
ASN A 185
 None
 0.77A 3lm8A-3ihkA:
11.4
3lm8C-3ihkA:
21.1		 3lm8A-3ihkA:
34.35
3lm8C-3ihkA:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 ASP C 230
LEU C 467
SER C 473
ASN C 474
 None
 0.96A 3lm8A-3j9uC:
2.4
3lm8C-3j9uC:
undetectable		 3lm8A-3j9uC:
16.91
3lm8C-3j9uC:
16.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 171
LEU A 173
SER A 187
ASN A 188
 None
CSO  A 176 ( 3.9A)
CSO  A 185 ( 3.2A)
None
 0.91A 3lm8A-3k94A:
31.0
3lm8C-3k94A:
30.4		 3lm8A-3k94A:
55.31
3lm8C-3k94A:
55.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
marinum) 		PF00797
(Acetyltransf_2) 		4 ASP A 127
TYR A 154
LEU A 156
LEU A 125
 None
 0.98A 3lm8A-3ltwA:
undetectable
3lm8C-3ltwA:
undetectable		 3lm8A-3ltwA:
21.81
3lm8C-3ltwA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mel THIAMIN
PYROPHOSPHOKINASE
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 174
LEU A 176
SER A 189
ASN A 190
 None
 0.70A 3lm8A-3melA:
24.7
3lm8C-3melA:
24.2		 3lm8A-3melA:
38.16
3lm8C-3melA:
38.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msv NUCLEAR IMPORT
ADAPTOR, NRO1

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		4 ASP A 310
TYR A 297
LEU A 301
SER A 317
 None
 0.99A 3lm8A-3msvA:
undetectable
3lm8C-3msvA:
undetectable		 3lm8A-3msvA:
20.15
3lm8C-3msvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa1 PHOSPHOPROTEIN

(Rabies
lyssavirus) 		PF03012
(PP_M1) 		4 LYS A 212
LEU A 230
LEU A 263
SER A 208
 None
 0.98A 3lm8A-3oa1A:
undetectable
3lm8C-3oa1A:
undetectable		 3lm8A-3oa1A:
23.28
3lm8C-3oa1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 LYS A  40
ASP A 296
LEU A  27
LEU A 298
 None
 0.94A 3lm8A-3oo3A:
undetectable
3lm8C-3oo3A:
undetectable		 3lm8A-3oo3A:
19.54
3lm8C-3oo3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		5 TYR A 170
LEU A 168
LEU A 179
SER A 140
ASN A 141
 None
 1.36A 3lm8A-3outA:
3.6
3lm8C-3outA:
2.7		 3lm8A-3outA:
23.57
3lm8C-3outA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 TYR A1050
LEU A 964
LEU A1062
SER A 969
 None
 1.03A 3lm8A-3poyA:
undetectable
3lm8C-3poyA:
undetectable		 3lm8A-3poyA:
13.76
3lm8C-3poyA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 672
LEU A 501
CYH A 594
SER A 592
 None
 0.74A 3lm8A-3ttfA:
2.6
3lm8C-3ttfA:
2.1		 3lm8A-3ttfA:
14.57
3lm8C-3ttfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD

(Pseudomonas
aeruginosa) 		PF14467
(DUF4426) 		4 LYS A  84
ASP A  80
LEU A 113
SER A  77
 None
 0.94A 3lm8A-3uc2A:
undetectable
3lm8C-3uc2A:
undetectable		 3lm8A-3uc2A:
20.81
3lm8C-3uc2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 298
LEU A 312
SER A 315
ASN A 317
 None
 1.03A 3lm8A-3wpeA:
undetectable
3lm8C-3wpeA:
undetectable		 3lm8A-3wpeA:
13.78
3lm8C-3wpeA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 690
LEU A 730
SER A 708
ASN A 709
 None
 0.91A 3lm8A-3wpeA:
undetectable
3lm8C-3wpeA:
undetectable		 3lm8A-3wpeA:
13.78
3lm8C-3wpeA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		4 LEU A 612
LEU A 694
CYH A 746
SER A 879
 None
 0.98A 3lm8A-3wxfA:
undetectable
3lm8C-3wxfA:
undetectable		 3lm8A-3wxfA:
19.57
3lm8C-3wxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ASP A2055
LEU A2038
LEU A2059
SER A2088
 None
 1.00A 3lm8A-3zbfA:
undetectable
3lm8C-3zbfA:
undetectable		 3lm8A-3zbfA:
22.73
3lm8C-3zbfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		4 LEU A 307
LEU A 276
CYH A 333
SER A 335
 None
 0.95A 3lm8A-3zdpA:
undetectable
3lm8C-3zdpA:
undetectable		 3lm8A-3zdpA:
16.70
3lm8C-3zdpA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		4 ASP A 277
LEU A  81
LEU A 280
ASN A 250
 None
 1.02A 3lm8A-4a9aA:
undetectable
3lm8C-4a9aA:
undetectable		 3lm8A-4a9aA:
20.58
3lm8C-4a9aA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 ASP A  34
LEU A 192
LEU A  33
ASN A 259
 None
 0.99A 3lm8A-4cczA:
undetectable
3lm8C-4cczA:
undetectable		 3lm8A-4cczA:
17.67
3lm8C-4cczA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE

(Pseudomonas
aeruginosa) 		PF04199
(Cyclase) 		4 LEU A 109
LEU A 187
CYH A  80
SER A 106
 None
 0.90A 3lm8A-4cobA:
undetectable
3lm8C-4cobA:
undetectable		 3lm8A-4cobA:
21.37
3lm8C-4cobA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		4 ASP A 125
TYR A 151
LEU A 153
LEU A 123
 None
 0.93A 3lm8A-4guzA:
undetectable
3lm8C-4guzA:
undetectable		 3lm8A-4guzA:
19.86
3lm8C-4guzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
APR  A 602 (-3.2A)
 0.88A 3lm8A-4iaoA:
2.6
3lm8C-4iaoA:
undetectable		 3lm8A-4iaoA:
18.62
3lm8C-4iaoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 LYS A  57
ASP A  26
LEU A  99
LEU A  78
 None
 0.97A 3lm8A-4kcaA:
undetectable
3lm8C-4kcaA:
undetectable		 3lm8A-4kcaA:
16.28
3lm8C-4kcaA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsz DARPIN D7.18

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LYS E 147
ASP E 143
SER E 153
ASN E 156
 None
 0.93A 3lm8A-4lszE:
undetectable
3lm8C-4lszE:
undetectable		 3lm8A-4lszE:
21.58
3lm8C-4lszE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ASP A 291
LEU A 257
LEU A 289
CYH A 254
 None
None
None
SO4  A 707 (-3.5A)
 0.97A 3lm8A-4nreA:
undetectable
3lm8C-4nreA:
undetectable		 3lm8A-4nreA:
15.19
3lm8C-4nreA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 LYS A 288
ASP A 286
LEU A 322
LEU A 283
 None
 1.02A 3lm8A-4phcA:
undetectable
3lm8C-4phcA:
undetectable		 3lm8A-4phcA:
16.90
3lm8C-4phcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpj CELL CYCLE RESPONSE
REGULATOR CTRA

(Brucella
abortus) 		PF00072
(Response_reg) 		4 ASP C  97
LEU C 108
LEU C  76
SER C  79
 None
 0.84A 3lm8A-4qpjC:
2.1
3lm8C-4qpjC:
2.6		 3lm8A-4qpjC:
21.05
3lm8C-4qpjC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtq XAC2610 PROTEIN

(Xanthomonas
citri) 		no annotation 4 TYR A 227
LEU A 229
LEU A 193
SER A 213
 None
 1.03A 3lm8A-4qtqA:
undetectable
3lm8C-4qtqA:
undetectable		 3lm8A-4qtqA:
21.81
3lm8C-4qtqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 ASP A 187
TYR A  15
LEU A  11
ASN A  49
 None
 0.92A 3lm8A-4tx1A:
undetectable
3lm8C-4tx1A:
2.4		 3lm8A-4tx1A:
21.16
3lm8C-4tx1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 ASP A 666
LEU A 650
LEU A 664
SER A 699
 None
 0.96A 3lm8A-4xprA:
3.1
3lm8C-4xprA:
undetectable		 3lm8A-4xprA:
13.37
3lm8C-4xprA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
PF04939
(RRS1) 		4 LYS A  51
TYR C 204
LEU C 206
SER C 183
 None
 1.03A 3lm8A-5a53A:
undetectable
3lm8C-5a53A:
undetectable		 3lm8A-5a53A:
18.06
3lm8C-5a53A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo4 SUPPRESSOR OF
CYTOKINE SIGNALING 2

(Homo sapiens) 		PF00017
(SH2)
PF07525
(SOCS_box) 		4 ASP A  74
LEU A  43
LEU A  82
SER A  85
 None
 1.00A 3lm8A-5bo4A:
undetectable
3lm8C-5bo4A:
undetectable		 3lm8A-5bo4A:
21.52
3lm8C-5bo4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 ASP A  48
LEU A  18
LEU A  49
SER A  56
 None
 0.96A 3lm8A-5ccxA:
3.0
3lm8C-5ccxA:
2.4		 3lm8A-5ccxA:
22.68
3lm8C-5ccxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		4 ASP C 590
TYR C 595
LEU C 597
LEU C 585
 None
 0.98A 3lm8A-5d9aC:
undetectable
3lm8C-5d9aC:
undetectable		 3lm8A-5d9aC:
13.81
3lm8C-5d9aC:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 TYR A 357
LEU A 178
SER A 354
ASN A 355
 None
 0.97A 3lm8A-5dldA:
2.2
3lm8C-5dldA:
2.8		 3lm8A-5dldA:
21.01
3lm8C-5dldA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN

(Chlamydomonas
reinhardtii) 		PF00085
(Thioredoxin)
PF13499
(EF-hand_7) 		4 ASP A 102
LEU A 104
SER A 176
ASN A 175
 ASP  A 102 ( 0.5A)
LEU  A 104 ( 0.6A)
SER  A 176 ( 0.0A)
ASN  A 175 ( 0.6A)
 0.98A 3lm8A-5e37A:
undetectable
3lm8C-5e37A:
undetectable		 3lm8A-5e37A:
21.21
3lm8C-5e37A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		4 ASP A 211
LEU A 332
LEU A 368
CYH A 369
 None
 1.01A 3lm8A-5fifA:
undetectable
3lm8C-5fifA:
undetectable		 3lm8A-5fifA:
16.17
3lm8C-5fifA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C

(Schizosaccharomyces
pombe) 		PF00956
(NAP) 		4 ASP A  69
TYR A 103
LEU A  73
ASN A 101
 None
 0.99A 3lm8A-5gplA:
undetectable
3lm8C-5gplA:
undetectable		 3lm8A-5gplA:
20.42
3lm8C-5gplA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 0.64A 3lm8A-5ko3A:
undetectable
3lm8C-5ko3A:
undetectable		 3lm8A-5ko3A:
19.93
3lm8C-5ko3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 ASP p 224
LEU p 265
LEU p 210
SER p 213
 None
 0.92A 3lm8A-5optp:
undetectable
3lm8C-5optp:
undetectable		 3lm8A-5optp:
22.16
3lm8C-5optp:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5x MCG133388, ISOFORM
CRA_Y

(Mus musculus) 		no annotation 4 LYS A 300
ASP A 286
LEU A 252
SER A 297
 None
 1.00A 3lm8A-5v5xA:
undetectable
3lm8C-5v5xA:
undetectable		 3lm8A-5v5xA:
19.09
3lm8C-5v5xA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 0.79A 3lm8A-5w8uA:
undetectable
3lm8C-5w8uA:
undetectable		 3lm8A-5w8uA:
19.14
3lm8C-5w8uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
PF04939
(RRS1) 		4 LYS B  51
TYR A 204
LEU A 206
SER A 183
 None
 0.99A 3lm8A-5wxlB:
undetectable
3lm8C-5wxlB:
undetectable		 3lm8A-5wxlB:
17.37
3lm8C-5wxlB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Komagataella
phaffii) 		PF06093
(Spt4) 		4 LEU V  36
LEU V  90
CYH V  49
SER V  51
 None
 0.81A 3lm8A-5xonV:
undetectable
3lm8C-5xonV:
undetectable		 3lm8A-5xonV:
17.76
3lm8C-5xonV:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 LEU A 693
LEU A 733
SER A 711
ASN A 712
 None
None
NAG  A 914 ( 4.1A)
None
 1.02A 3lm8A-5zlnA:
undetectable
3lm8C-5zlnA:
undetectable		 3lm8A-5zlnA:
17.05
3lm8C-5zlnA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 4 TYR A 575
LEU A 577
LEU A 541
SER A 561
 None
 1.00A 3lm8A-6eoqA:
undetectable
3lm8C-6eoqA:
undetectable		 3lm8A-6eoqA:
19.57
3lm8C-6eoqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 4 TYR A 600
LEU A 602
LEU A 566
SER A 586
 None
 1.02A 3lm8A-6eotA:
undetectable
3lm8C-6eotA:
undetectable		 3lm8A-6eotA:
13.96
3lm8C-6eotA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 TYR A1351
LEU A1350
LEU A1830
CYH A1354
 None
 0.78A 3lm8A-6ez8A:
undetectable
3lm8C-6ez8A:
undetectable		 3lm8A-6ez8A:
11.52
3lm8C-6ez8A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 ASP A 651
LEU A 648
LEU A 676
SER A 673
 None
 0.99A 3lm8A-6faeA:
undetectable
3lm8C-6faeA:
undetectable		 3lm8A-6faeA:
14.61
3lm8C-6faeA:
14.61