SIMILAR PATTERNS OF AMINO ACIDS FOR 3LM8_B_VIBB223

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 TYR A 129
LEU A 211
LEU A 154
THR A 104
 DHP  A 361 ( 4.3A)
None
None
None
 1.04A 3lm8B-1al8A:
undetectable
3lm8D-1al8A:
undetectable		 3lm8B-1al8A:
20.89
3lm8D-1al8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 LEU A 440
LEU A 375
SER A 259
THR A 265
 None
PC1  A 778 (-4.3A)
None
None
 1.07A 3lm8B-1bp1A:
undetectable
3lm8D-1bp1A:
undetectable		 3lm8B-1bp1A:
17.11
3lm8D-1bp1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf0 PROTEIN (PROFILIN)

(Homo sapiens) 		PF00235
(Profilin) 		4 LEU A  50
LEU A  65
SER A  71
THR A  97
 None
 1.05A 3lm8B-1cf0A:
undetectable
3lm8D-1cf0A:
undetectable		 3lm8B-1cf0A:
19.65
3lm8D-1cf0A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 LEU A1089
LEU A1103
SER A1126
ASN A1125
 None
 1.03A 3lm8B-1e69A:
undetectable
3lm8D-1e69A:
undetectable		 3lm8B-1e69A:
23.53
3lm8D-1e69A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 TYR A1066
LEU A1084
LEU A1156
SER A1184
 None
 1.06A 3lm8B-1foeA:
undetectable
3lm8D-1foeA:
undetectable		 3lm8B-1foeA:
19.37
3lm8D-1foeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 LEU A 165
LEU A 240
CYH A 241
SER A 246
 None
 0.98A 3lm8B-1httA:
undetectable
3lm8D-1httA:
undetectable		 3lm8B-1httA:
19.20
3lm8D-1httA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mai PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF16457
(PH_12) 		4 TYR A  42
LEU A  22
LEU A 125
THR A 107
 None
 1.00A 3lm8B-1maiA:
undetectable
3lm8D-1maiA:
undetectable		 3lm8B-1maiA:
21.46
3lm8D-1maiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 LEU A 348
LEU A 341
SER A 243
ASN A 245
 None
 0.82A 3lm8B-1qonA:
undetectable
3lm8D-1qonA:
0.8		 3lm8B-1qonA:
17.58
3lm8D-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		4 LEU A 153
LEU A 172
SER A  94
THR A 191
 None
None
SO4  A 601 (-2.6A)
SO4  A 601 ( 4.5A)
 1.00A 3lm8B-1qwrA:
2.5
3lm8D-1qwrA:
3.2		 3lm8B-1qwrA:
21.85
3lm8D-1qwrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri9 FYN-BINDING PROTEIN

(Homo sapiens) 		PF14603
(hSH3) 		4 TYR A  73
LEU A  45
LEU A  53
CYH A  66
 None
 1.01A 3lm8B-1ri9A:
undetectable
3lm8D-1ri9A:
undetectable		 3lm8B-1ri9A:
18.14
3lm8D-1ri9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 TYR A 135
CYH A 137
ASN A 136
THR A 145
 None
 1.06A 3lm8B-1ry2A:
undetectable
3lm8D-1ry2A:
2.8		 3lm8B-1ry2A:
17.35
3lm8D-1ry2A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 LEU A 233
LEU A 262
SER A 269
THR A 334
 None
 0.90A 3lm8B-1tlfA:
4.7
3lm8D-1tlfA:
5.2		 3lm8B-1tlfA:
21.04
3lm8D-1tlfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 TYR A 272
LEU A 287
ASN A 171
THR A 180
 None
 0.93A 3lm8B-1v84A:
undetectable
3lm8D-1v84A:
2.5		 3lm8B-1v84A:
19.78
3lm8D-1v84A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 TYR A 392
LEU A 376
SER A 369
ASN A 371
 None
 1.04A 3lm8B-2dkhA:
undetectable
3lm8D-2dkhA:
undetectable		 3lm8B-2dkhA:
16.69
3lm8D-2dkhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 TYR A 392
LEU A 389
LEU A 376
THR A  46
 None
 1.02A 3lm8B-2dkhA:
undetectable
3lm8D-2dkhA:
undetectable		 3lm8B-2dkhA:
16.69
3lm8D-2dkhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		4 LEU A 307
LEU A 492
SER A 498
THR A 479
 None
 1.05A 3lm8B-2e0wA:
undetectable
3lm8D-2e0wA:
undetectable		 3lm8B-2e0wA:
17.89
3lm8D-2e0wA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		4 LEU A 307
LEU B 492
SER B 498
THR B 479
 None
 0.96A 3lm8B-2e0xA:
undetectable
3lm8D-2e0xA:
undetectable		 3lm8B-2e0xA:
19.02
3lm8D-2e0xA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
XYQ  A1222 (-3.3A)
 0.88A 3lm8B-2hjhA:
2.8
3lm8D-2hjhA:
undetectable		 3lm8B-2hjhA:
20.45
3lm8D-2hjhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqj MG2+ TRANSPORT
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 207
LEU A 197
SER A 172
ASN A 174
 None
 1.06A 3lm8B-2lqjA:
undetectable
3lm8D-2lqjA:
undetectable		 3lm8B-2lqjA:
14.29
3lm8D-2lqjA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A 208
LEU A 361
ASN A 405
THR A 193
 None
 1.04A 3lm8B-2nz9A:
undetectable
3lm8D-2nz9A:
undetectable		 3lm8B-2nz9A:
10.87
3lm8D-2nz9A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		4 LEU A  57
SER A  24
ASN A  27
THR A 241
 None
SKP  A 501 (-2.6A)
None
None
 0.93A 3lm8B-2o0xA:
undetectable
3lm8D-2o0xA:
undetectable		 3lm8B-2o0xA:
17.53
3lm8D-2o0xA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 LEU B 203
LEU B 189
SER B 192
ASN B 219
 None
 1.03A 3lm8B-2p1nB:
undetectable
3lm8D-2p1nB:
undetectable		 3lm8B-2p1nB:
14.81
3lm8D-2p1nB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		4 TYR A 241
LEU A 209
LEU A 223
THR A 269
 None
 1.00A 3lm8B-2pb0A:
undetectable
3lm8D-2pb0A:
undetectable		 3lm8B-2pb0A:
18.01
3lm8D-2pb0A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 LEU A 276
LEU A 278
SER A 344
ASN A 346
 None
 0.94A 3lm8B-2vhlA:
1.9
3lm8D-2vhlA:
undetectable		 3lm8B-2vhlA:
20.25
3lm8D-2vhlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		4 LEU A 161
LEU A 140
SER A  40
THR A 112
 None
 1.05A 3lm8B-2xhgA:
undetectable
3lm8D-2xhgA:
undetectable		 3lm8B-2xhgA:
19.75
3lm8D-2xhgA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 LEU A  40
LEU A 191
CYH A 195
SER A 197
 None
 1.02A 3lm8B-2xhyA:
undetectable
3lm8D-2xhyA:
undetectable		 3lm8B-2xhyA:
18.18
3lm8D-2xhyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		4 TYR A  14
LEU A 670
CYH A  16
SER A  11
 None
 1.01A 3lm8B-2y35A:
4.1
3lm8D-2y35A:
3.4		 3lm8B-2y35A:
10.88
3lm8D-2y35A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 120
LEU A 130
SER A 133
ASN A 135
 None
 1.06A 3lm8B-3bz5A:
undetectable
3lm8D-3bz5A:
undetectable		 3lm8B-3bz5A:
16.70
3lm8D-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 162
LEU A 172
SER A 175
ASN A 177
 None
 1.06A 3lm8B-3bz5A:
undetectable
3lm8D-3bz5A:
undetectable		 3lm8B-3bz5A:
16.70
3lm8D-3bz5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 226
LEU A 236
SER A 239
ASN A 241
 None
 0.98A 3lm8B-3bz5A:
undetectable
3lm8D-3bz5A:
undetectable		 3lm8B-3bz5A:
16.70
3lm8D-3bz5A:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 TYR A 174
LEU A 169
SER A 189
ASN A 190
 None
 1.02A 3lm8B-3cq9A:
23.9
3lm8D-3cq9A:
22.3		 3lm8B-3cq9A:
41.35
3lm8D-3cq9A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		4 TYR A 174
LEU A 176
SER A 189
ASN A 190
 None
 0.38A 3lm8B-3cq9A:
23.9
3lm8D-3cq9A:
22.3		 3lm8B-3cq9A:
41.35
3lm8D-3cq9A:
41.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiw PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 TYR A  44
LEU A  51
LEU A  30
SER A  40
 None
 0.91A 3lm8B-3fiwA:
undetectable
3lm8D-3fiwA:
undetectable		 3lm8B-3fiwA:
21.67
3lm8D-3fiwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		4 LEU A 154
SER A 160
ASN A 162
THR A 124
 None
None
PG4  A 280 ( 4.9A)
None
 0.99A 3lm8B-3fs2A:
undetectable
3lm8D-3fs2A:
undetectable		 3lm8B-3fs2A:
20.78
3lm8D-3fs2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8k LECTIN-RELATED NK
CELL RECEPTOR LY49L1

(Mus musculus) 		PF00059
(Lectin_C) 		4 TYR A 198
LEU A 178
LEU A 189
SER A 239
 None
 1.02A 3lm8B-3g8kA:
undetectable
3lm8D-3g8kA:
undetectable		 3lm8B-3g8kA:
19.72
3lm8D-3g8kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8l LECTIN-RELATED NK
CELL RECEPTOR LY49L1

(Mus musculus) 		PF00059
(Lectin_C)
PF08391
(Ly49) 		4 TYR A 198
LEU A 178
LEU A 189
SER A 239
 None
 0.84A 3lm8B-3g8lA:
undetectable
3lm8D-3g8lA:
undetectable		 3lm8B-3g8lA:
22.13
3lm8D-3g8lA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 TYR A 149
LEU A 151
LEU A 223
THR A 115
 None
GOL  A   1 (-3.4A)
GOL  A   1 (-4.6A)
None
 0.93A 3lm8B-3hztA:
undetectable
3lm8D-3hztA:
undetectable		 3lm8B-3hztA:
18.11
3lm8D-3hztA:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ihk THIAMIN
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 169
LEU A 171
SER A 184
ASN A 185
 None
 0.73A 3lm8B-3ihkA:
21.4
3lm8D-3ihkA:
10.8		 3lm8B-3ihkA:
34.35
3lm8D-3ihkA:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijm UNCHARACTERIZED
RESTRICTION
ENDONUCLEASE-LIKE
FOLD SUPERFAMILY
PROTEIN

(Spirosoma
linguale) 		no annotation 4 TYR A  41
LEU A  37
LEU A  69
THR A  74
 None
 1.06A 3lm8B-3ijmA:
undetectable
3lm8D-3ijmA:
undetectable		 3lm8B-3ijmA:
21.17
3lm8D-3ijmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 4 LEU A  40
LEU A  77
CYH A  74
THR A  90
 None
None
PAC  A5000 (-3.5A)
None
 1.04A 3lm8B-3ixlA:
undetectable
3lm8D-3ixlA:
4.0		 3lm8B-3ixlA:
21.65
3lm8D-3ixlA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mel THIAMIN
PYROPHOSPHOKINASE
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 TYR A 174
LEU A 176
SER A 189
ASN A 190
 None
 0.50A 3lm8B-3melA:
24.6
3lm8D-3melA:
24.0		 3lm8B-3melA:
38.16
3lm8D-3melA:
38.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 TYR A 259
LEU A 261
LEU A 302
THR A 251
 None
 0.99A 3lm8B-3n2xA:
undetectable
3lm8D-3n2xA:
undetectable		 3lm8B-3n2xA:
20.63
3lm8D-3n2xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmb PUTATIVE SUGAR
HYDROLASE

(Bacteroides
ovatus) 		PF06439
(DUF1080) 		4 LEU A 230
LEU A 138
CYH A 259
ASN A 258
 None
 1.05A 3lm8B-3nmbA:
undetectable
3lm8D-3nmbA:
undetectable		 3lm8B-3nmbA:
24.46
3lm8D-3nmbA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		5 TYR A 170
LEU A 168
LEU A 179
SER A 140
ASN A 141
 None
 1.27A 3lm8B-3outA:
3.2
3lm8D-3outA:
3.3		 3lm8B-3outA:
23.57
3lm8D-3outA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf0 IMELYSIN-LIKE
PROTEIN

(Psychrobacter
arcticus) 		PF09375
(Peptidase_M75) 		4 LEU A 347
LEU A 358
SER A 268
THR A 366
 None
 1.00A 3lm8B-3pf0A:
undetectable
3lm8D-3pf0A:
undetectable		 3lm8B-3pf0A:
21.10
3lm8D-3pf0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Vibrio cholerae) 		PF01648
(ACPS) 		4 LEU A 123
LEU A  88
SER A  91
THR A  32
 None
 1.01A 3lm8B-3qmnA:
undetectable
3lm8D-3qmnA:
undetectable		 3lm8B-3qmnA:
21.80
3lm8D-3qmnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 LEU A 672
LEU A 501
CYH A 594
SER A 592
 None
 0.91A 3lm8B-3ttfA:
2.5
3lm8D-3ttfA:
undetectable		 3lm8B-3ttfA:
14.57
3lm8D-3ttfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		4 LEU A 204
SER A 210
ASN A 211
THR A 240
 None
 1.03A 3lm8B-3v3tA:
4.6
3lm8D-3v3tA:
4.2		 3lm8B-3v3tA:
20.69
3lm8D-3v3tA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		4 LEU A 384
LEU A 444
SER A 365
THR A 279
 None
 0.94A 3lm8B-3wbhA:
2.2
3lm8D-3wbhA:
1.8		 3lm8B-3wbhA:
17.73
3lm8D-3wbhA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 690
LEU A 730
SER A 708
ASN A 709
 None
 0.85A 3lm8B-3wpeA:
undetectable
3lm8D-3wpeA:
undetectable		 3lm8B-3wpeA:
13.78
3lm8D-3wpeA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 LEU A 208
LEU A 361
ASN A 405
THR A 193
 None
 0.78A 3lm8B-3zusA:
undetectable
3lm8D-3zusA:
undetectable		 3lm8B-3zusA:
13.58
3lm8D-3zusA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq2 HOMOGENTISATE
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF04209
(HgmA) 		4 LEU A 166
LEU A  64
SER A  48
ASN A 268
 None
 1.00A 3lm8B-4aq2A:
undetectable
3lm8D-4aq2A:
undetectable		 3lm8B-4aq2A:
16.17
3lm8D-4aq2A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D

(Phanerochaete
chrysosporium) 		PF03443
(Glyco_hydro_61) 		4 TYR A 198
LEU A 200
LEU A 117
THR A 121
 None
 1.06A 3lm8B-4b5qA:
undetectable
3lm8D-4b5qA:
undetectable		 3lm8B-4b5qA:
21.31
3lm8D-4b5qA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE

(Pseudomonas
aeruginosa) 		PF04199
(Cyclase) 		4 LEU A 109
LEU A 187
CYH A  80
SER A 106
 None
 0.87A 3lm8B-4cobA:
undetectable
3lm8D-4cobA:
undetectable		 3lm8B-4cobA:
21.37
3lm8D-4cobA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A 114
SER A 154
ASN A 153
THR A 148
 None
 1.06A 3lm8B-4eudA:
2.9
3lm8D-4eudA:
2.7		 3lm8B-4eudA:
18.84
3lm8D-4eudA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus) 		PF16396
(DUF5005) 		4 LEU A 356
LEU A 389
SER A 392
THR A  81
 None
 0.82A 3lm8B-4hbsA:
undetectable
3lm8D-4hbsA:
undetectable		 3lm8B-4hbsA:
20.48
3lm8D-4hbsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 TYR N 375
LEU N 376
LEU N 331
THR N 287
 None
 0.93A 3lm8B-4heaN:
undetectable
3lm8D-4heaN:
undetectable		 3lm8B-4heaN:
16.94
3lm8D-4heaN:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		4 LEU B 131
LEU B 142
SER B 138
THR B 199
 None
 0.94A 3lm8B-4i6jB:
undetectable
3lm8D-4i6jB:
undetectable		 3lm8B-4i6jB:
20.57
3lm8D-4i6jB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 LEU A 474
LEU A 260
CYH A 469
ASN A 496
 None
None
None
APR  A 602 (-3.2A)
 0.87A 3lm8B-4iaoA:
3.3
3lm8D-4iaoA:
2.9		 3lm8B-4iaoA:
18.62
3lm8D-4iaoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 TYR A 250
LEU A 254
LEU A 183
SER A 188
 None
 1.05A 3lm8B-4jr7A:
undetectable
3lm8D-4jr7A:
undetectable		 3lm8B-4jr7A:
22.25
3lm8D-4jr7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 TYR A 790
LEU A 807
LEU A 801
THR A 735
 None
 1.01A 3lm8B-4om9A:
undetectable
3lm8D-4om9A:
undetectable		 3lm8B-4om9A:
12.03
3lm8D-4om9A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 LEU A  75
LEU A 113
SER A  91
ASN A  92
 None
 0.94A 3lm8B-4p8sA:
undetectable
3lm8D-4p8sA:
undetectable		 3lm8B-4p8sA:
20.42
3lm8D-4p8sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 272
LEU A 312
SER A 290
ASN A 291
 None
None
NAG  A 505 ( 3.2A)
None
 1.02A 3lm8B-4qdhA:
undetectable
3lm8D-4qdhA:
undetectable		 3lm8B-4qdhA:
18.65
3lm8D-4qdhA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 TYR L 370
LEU L 364
SER L 342
THR L 503
 None
 0.87A 3lm8B-4u9iL:
undetectable
3lm8D-4u9iL:
undetectable		 3lm8B-4u9iL:
16.79
3lm8D-4u9iL:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 4 LEU E 664
LEU E 679
SER E 704
ASN E 706
 None
 1.00A 3lm8B-4xmmE:
undetectable
3lm8D-4xmmE:
undetectable		 3lm8B-4xmmE:
11.96
3lm8D-4xmmE:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 469
LEU A 454
SER A 457
THR A 408
 None
 1.07A 3lm8B-4z61A:
undetectable
3lm8D-4z61A:
undetectable		 3lm8B-4z61A:
14.33
3lm8D-4z61A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		4 LEU A2098
LEU A2055
SER A2045
THR A2010
 None
 1.01A 3lm8B-5b4xA:
3.0
3lm8D-5b4xA:
2.7		 3lm8B-5b4xA:
14.76
3lm8D-5b4xA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyp SEPTIN-9

(Homo sapiens) 		PF00735
(Septin) 		4 LEU A  43
LEU A  83
SER A  69
THR A 131
 None
 0.91A 3lm8B-5cypA:
undetectable
3lm8D-5cypA:
undetectable		 3lm8B-5cypA:
24.56
3lm8D-5cypA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhm IMMUNOREACTIVE 32
KDA ANTIGEN

(Porphyromonas
gingivalis) 		no annotation 4 LEU C 266
LEU C 205
SER C 251
ASN C 253
 None
 1.06A 3lm8B-5dhmC:
undetectable
3lm8D-5dhmC:
undetectable		 3lm8B-5dhmC:
21.05
3lm8D-5dhmC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU A 332
LEU A 344
CYH A 335
SER A 337
 None
 1.04A 3lm8B-5flzA:
undetectable
3lm8D-5flzA:
undetectable		 3lm8B-5flzA:
13.37
3lm8D-5flzA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 TYR A 393
LEU A 390
LEU A 283
ASN A 379
 None
 1.05A 3lm8B-5flzA:
undetectable
3lm8D-5flzA:
undetectable		 3lm8B-5flzA:
13.37
3lm8D-5flzA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		4 TYR E 230
SER E 206
ASN E 207
THR E 160
 None
 1.05A 3lm8B-5ginE:
2.1
3lm8D-5ginE:
2.3		 3lm8B-5ginE:
22.05
3lm8D-5ginE:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU A 605
LEU A 589
SER A 592
THR A 538
 None
None
NAG  A 912 ( 4.7A)
NAG  A 912 ( 4.7A)
 1.05A 3lm8B-5hdhA:
undetectable
3lm8D-5hdhA:
undetectable		 3lm8B-5hdhA:
14.66
3lm8D-5hdhA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 LEU A  79
LEU A  40
SER A 106
THR A 232
 None
 1.06A 3lm8B-5i5lA:
undetectable
3lm8D-5i5lA:
undetectable		 3lm8B-5i5lA:
18.22
3lm8D-5i5lA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 LEU V 455
LEU V 364
SER V 411
THR V 393
 None
 0.52A 3lm8B-5iy6V:
undetectable
3lm8D-5iy6V:
undetectable		 3lm8B-5iy6V:
14.73
3lm8D-5iy6V:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		4 TYR A  39
LEU A  40
LEU A 208
SER A  32
 None
 1.04A 3lm8B-5j78A:
3.3
3lm8D-5j78A:
4.6		 3lm8B-5j78A:
19.26
3lm8D-5j78A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		4 LEU A 139
LEU A 115
CYH A 129
ASN A 128
 None
 0.97A 3lm8B-5jwbA:
undetectable
3lm8D-5jwbA:
undetectable		 3lm8B-5jwbA:
19.76
3lm8D-5jwbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 275
LEU A 283
ASN A 300
THR A 305
 None
 1.06A 3lm8B-5lfnA:
undetectable
3lm8D-5lfnA:
undetectable		 3lm8B-5lfnA:
21.97
3lm8D-5lfnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 LEU A 621
LEU A 590
SER A 593
THR A 542
 None
 0.83A 3lm8B-5n8pA:
undetectable
3lm8D-5n8pA:
undetectable		 3lm8B-5n8pA:
10.43
3lm8D-5n8pA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 LEU A 621
LEU A 590
SER A 593
THR A 542
 None
 0.84A 3lm8B-5n97A:
undetectable
3lm8D-5n97A:
undetectable		 3lm8B-5n97A:
11.95
3lm8D-5n97A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 LEU A 405
LEU A 565
SER A 577
THR A 107
 None
 0.98A 3lm8B-5nbsA:
undetectable
3lm8D-5nbsA:
2.7		 3lm8B-5nbsA:
16.11
3lm8D-5nbsA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		4 LEU A 261
SER A 265
ASN A 264
THR A 272
 None
 1.00A 3lm8B-5nlaA:
undetectable
3lm8D-5nlaA:
undetectable		 3lm8B-5nlaA:
18.93
3lm8D-5nlaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oh6 INTERAPTIN

(Legionella
pneumophila) 		no annotation 4 LEU A 199
LEU A 183
SER A 189
THR A 125
 None
 1.02A 3lm8B-5oh6A:
undetectable
3lm8D-5oh6A:
undetectable		 3lm8B-5oh6A:
18.77
3lm8D-5oh6A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Homo sapiens) 		PF06093
(Spt4) 		4 LEU Y  40
LEU Y  93
CYH Y  52
SER Y  54
 None
 1.06A 3lm8B-5oikY:
undetectable
3lm8D-5oikY:
undetectable		 3lm8B-5oikY:
19.09
3lm8D-5oikY:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 4 LEU B 185
LEU B 203
ASN B 235
THR B 217
 None
 1.06A 3lm8B-5op0B:
undetectable
3lm8D-5op0B:
undetectable		 3lm8B-5op0B:
21.41
3lm8D-5op0B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 TYR A 339
LEU A 337
LEU A 304
SER A 301
 None
 0.97A 3lm8B-5t88A:
undetectable
3lm8D-5t88A:
2.2		 3lm8B-5t88A:
16.45
3lm8D-5t88A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 LEU A1392
LEU A1358
SER A1364
THR A 345
 None
 1.04A 3lm8B-5tj2A:
undetectable
3lm8D-5tj2A:
undetectable		 3lm8B-5tj2A:
17.15
3lm8D-5tj2A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  32
LEU A  41
ASN A  61
THR A  97
 None
None
NAP  A 304 ( 4.2A)
EDO  A 310 ( 3.7A)
 1.03A 3lm8B-5tjzA:
2.4
3lm8D-5tjzA:
2.9		 3lm8B-5tjzA:
20.81
3lm8D-5tjzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 241
LEU A1139
SER A1144
THR A1255
 None
 0.97A 3lm8B-5ujaA:
undetectable
3lm8D-5ujaA:
undetectable		 3lm8B-5ujaA:
9.09
3lm8D-5ujaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN

(Zea mays) 		PF07714
(Pkinase_Tyr) 		4 LEU A 759
LEU A 786
SER A 775
THR A 906
 None
None
ANP  A1101 (-2.6A)
MG  A1102 ( 4.6A)
 0.99A 3lm8B-5uv4A:
undetectable
3lm8D-5uv4A:
undetectable		 3lm8B-5uv4A:
21.05
3lm8D-5uv4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		4 LEU A 166
CYH A 403
ASN A 406
THR A 355
 None
None
97Y  A1201 (-3.8A)
97Y  A1201 (-3.3A)
 1.03A 3lm8B-5vewA:
undetectable
3lm8D-5vewA:
undetectable		 3lm8B-5vewA:
19.38
3lm8D-5vewA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Komagataella
phaffii) 		PF06093
(Spt4) 		4 LEU V  36
LEU V  90
CYH V  49
SER V  51
 None
 0.73A 3lm8B-5xonV:
undetectable
3lm8D-5xonV:
undetectable		 3lm8B-5xonV:
17.76
3lm8D-5xonV:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3s -

(-) 		no annotation 4 LEU A 800
LEU A 813
SER A 816
ASN A 818
 None
 1.02A 3lm8B-5y3sA:
undetectable
3lm8D-5y3sA:
undetectable		 3lm8B-5y3sA:
undetectable
3lm8D-5y3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2

(Arabidopsis
thaliana) 		no annotation 4 LEU A 154
LEU A 130
ASN A 126
THR A 167
 None
 0.71A 3lm8B-5y92A:
2.8
3lm8D-5y92A:
2.7		 3lm8B-5y92A:
13.45
3lm8D-5y92A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y96 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR1

(Arabidopsis
thaliana) 		no annotation 4 LEU B 153
LEU B 129
ASN B 125
THR B 166
 None
 1.02A 3lm8B-5y96B:
undetectable
3lm8D-5y96B:
undetectable		 3lm8B-5y96B:
20.75
3lm8D-5y96B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 LEU A 693
LEU A 733
SER A 711
ASN A 712
 None
None
NAG  A 914 ( 4.1A)
None
 0.91A 3lm8B-5zlnA:
undetectable
3lm8D-5zlnA:
undetectable		 3lm8B-5zlnA:
17.05
3lm8D-5zlnA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 4 LEU A 407
LEU A 396
ASN A 670
THR A 388
 None
 1.06A 3lm8B-6byiA:
undetectable
3lm8D-6byiA:
3.8		 3lm8B-6byiA:
undetectable
3lm8D-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 TYR A1351
LEU A1350
LEU A1830
CYH A1354
 None
 0.77A 3lm8B-6ez8A:
undetectable
3lm8D-6ez8A:
undetectable		 3lm8B-6ez8A:
11.52
3lm8D-6ez8A:
11.52