SIMILAR PATTERNS OF AMINO ACIDS FOR 3LK0_D_Z80D92_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8t PROTEIN (CRP1)

(Gallus gallus) 		PF00412
(LIM) 		3 HIS A  52
PHE A  35
PHE A  30
 None
 0.66A 3lk0D-1b8tA:
undetectable		 3lk0D-1b8tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 HIS A 204
PHE A 198
PHE A 580
 None
 0.64A 3lk0D-1ebvA:
0.0		 3lk0D-1ebvA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		3 HIS A  98
PHE A 112
PHE A 113
 None
 0.45A 3lk0D-1egzA:
undetectable		 3lk0D-1egzA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 HIS A 331
PHE A 349
PHE A 350
 None
 0.59A 3lk0D-1g01A:
undetectable		 3lk0D-1g01A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ky3 GTP-BINDING PROTEIN
YPT7P

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 HIS A 110
PHE A 119
PHE A 121
 None
 0.77A 3lk0D-1ky3A:
0.0		 3lk0D-1ky3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m56 CYTOCHROME C OXIDASE

(Rhodobacter
sphaeroides) 		PF00510
(COX3) 		3 HIS C 188
PHE C 202
PHE C 203
 None
 0.78A 3lk0D-1m56C:
undetectable		 3lk0D-1m56C:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mho S-100 PROTEIN

(Bos taurus) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		3 HIS A  42
PHE A  87
PHE A  88
 None
 0.59A 3lk0D-1mhoA:
18.2		 3lk0D-1mhoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		3 HIS A 210
PHE A 175
PHE A 172
 None
 0.64A 3lk0D-1q5dA:
undetectable		 3lk0D-1q5dA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		3 HIS A  52
PHE A  79
PHE A  34
 CIT  A 401 (-3.8A)
None
None
 0.75A 3lk0D-1qmhA:
undetectable		 3lk0D-1qmhA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		3 HIS A 610
PHE A 656
PHE A 594
 None
 0.75A 3lk0D-1ttuA:
undetectable		 3lk0D-1ttuA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		3 HIS A 200
PHE A 245
PHE A 246
 EPE  A 700 (-4.0A)
None
None
 0.36A 3lk0D-1tvpA:
undetectable		 3lk0D-1tvpA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		3 HIS A  83
PHE A  94
PHE A  95
 None
 0.80A 3lk0D-1vzvA:
0.0		 3lk0D-1vzvA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 HIS A2397
PHE A2391
PHE A2350
 None
 0.73A 3lk0D-1wchA:
0.3		 3lk0D-1wchA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		3 HIS A 444
PHE A 110
PHE A 111
 None
 0.77A 3lk0D-1wnbA:
undetectable		 3lk0D-1wnbA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 HIS A 122
PHE A 215
PHE A 216
 None
 0.70A 3lk0D-2aaaA:
undetectable		 3lk0D-2aaaA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 HIS A 143
PHE A 329
PHE A 311
 EOH  A1446 (-3.5A)
None
None
 0.78A 3lk0D-2bmoA:
0.0		 3lk0D-2bmoA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckr ENDOGLUCANASE E-5

(Thermobifida
fusca) 		PF00150
(Cellulase) 		3 HIS A 225
PHE A 242
PHE A 243
 None
 0.47A 3lk0D-2ckrA:
undetectable		 3lk0D-2ckrA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dnn RNA-BINDING PROTEIN
12

(Homo sapiens) 		no annotation 3 HIS A 239
PHE A 253
PHE A 254
 None
 0.74A 3lk0D-2dnnA:
undetectable		 3lk0D-2dnnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 HIS A 253
PHE A 210
PHE A 196
 None
 0.72A 3lk0D-2dw4A:
1.5		 3lk0D-2dw4A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		3 HIS A 107
PHE A 114
PHE A 145
 None
 0.68A 3lk0D-2e6mA:
0.0		 3lk0D-2e6mA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		3 HIS A 234
PHE A 283
PHE A 284
 None
 0.68A 3lk0D-2h2wA:
undetectable		 3lk0D-2h2wA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 HIS A 415
PHE A 422
PHE A  14
 None
 0.70A 3lk0D-2hneA:
undetectable		 3lk0D-2hneA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		3 HIS A 162
PHE A 249
PHE A 253
 None
 0.77A 3lk0D-2jjfA:
undetectable		 3lk0D-2jjfA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		3 HIS A 162
PHE A 254
PHE A 253
 None
 0.65A 3lk0D-2jjfA:
undetectable		 3lk0D-2jjfA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2f APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		3 HIS A 183
PHE A 147
PHE A 148
 None
 0.61A 3lk0D-2o2fA:
undetectable		 3lk0D-2o2fA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 HIS A 339
PHE A 236
PHE A 237
 None
 0.68A 3lk0D-2ox4A:
undetectable		 3lk0D-2ox4A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 HIS A 110
PHE A 216
PHE A 241
 FE  A 253 (-3.2A)
None
None
 0.73A 3lk0D-2qedA:
undetectable		 3lk0D-2qedA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qik UPF0131 PROTEIN YKQA

(Bacillus
subtilis) 		PF06094
(GGACT)
PF13772
(AIG2_2) 		3 HIS A  18
PHE A  75
PHE A  76
 None
 0.73A 3lk0D-2qikA:
undetectable		 3lk0D-2qikA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 HIS A 129
PHE A 132
PHE A 187
 None
 0.75A 3lk0D-2vd9A:
undetectable		 3lk0D-2vd9A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep) 		3 HIS A 162
PHE A 103
PHE A 104
 ZN  A1342 (-3.4A)
None
None
 0.51A 3lk0D-2vqxA:
undetectable		 3lk0D-2vqxA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		3 HIS A  90
PHE A  74
PHE A  94
 LP6  A 110 ( 4.1A)
None
None
 0.78A 3lk0D-2w7zA:
undetectable		 3lk0D-2w7zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		3 HIS A 391
PHE A 360
PHE A 359
 None
 0.72A 3lk0D-2weuA:
0.0		 3lk0D-2weuA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 HIS A 159
PHE A 339
PHE A 338
 None
 0.72A 3lk0D-2xt6A:
0.4		 3lk0D-2xt6A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		3 HIS A 717
PHE A 729
PHE A 730
 None
 0.55A 3lk0D-2yevA:
undetectable		 3lk0D-2yevA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx8 RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1

(Homo sapiens) 		PF04901
(RAMP) 		3 HIS A  75
PHE A  92
PHE A  93
 None
 0.56A 3lk0D-2yx8A:
undetectable		 3lk0D-2yx8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 HIS A 101
PHE A 118
PHE A 119
 CTR  A   1 (-4.0A)
None
None
 0.57A 3lk0D-3a3hA:
undetectable		 3lk0D-3a3hA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 HIS A  95
PHE A  68
PHE A  69
 None
 0.78A 3lk0D-3afeA:
undetectable		 3lk0D-3afeA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhn THIJ/PFPI DOMAIN
PROTEIN

(Shewanella
loihica) 		PF01965
(DJ-1_PfpI) 		3 HIS A  43
PHE A  17
PHE A  18
 None
EDO  A 220 (-4.8A)
None
 0.57A 3lk0D-3bhnA:
undetectable		 3lk0D-3bhnA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsg ALPHA/BETA
SUPERFAMILY
HYDROLASE

(Oenococcus oeni) 		PF12697
(Abhydrolase_6) 		3 HIS A 257
PHE A  38
PHE A  37
 None
 0.78A 3lk0D-3fsgA:
undetectable		 3lk0D-3fsgA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		3 HIS A 544
PHE A 428
PHE A 427
 None
DCP  A 101 (-3.8A)
None
 0.63A 3lk0D-3gqcA:
undetectable		 3lk0D-3gqcA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 HIS A 637
PHE A 651
PHE A 652
 None
 0.61A 3lk0D-3h0gA:
undetectable		 3lk0D-3h0gA:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3haj HUMAN PACSIN2 F-BAR

(Homo sapiens) 		PF00611
(FCH) 		3 HIS A  36
PHE A 244
PHE A 245
 None
 0.76A 3lk0D-3hajA:
undetectable		 3lk0D-3hajA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 HIS A 239
PHE A 204
PHE A 247
 None
 0.74A 3lk0D-3hx3A:
undetectable		 3lk0D-3hx3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 374
PHE A 314
PHE A 315
 None
 0.67A 3lk0D-3kbhA:
undetectable		 3lk0D-3kbhA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khy PROPIONATE KINASE

(Francisella
tularensis) 		PF00871
(Acetate_kinase) 		3 HIS A 121
PHE A 127
PHE A  63
 None
 0.55A 3lk0D-3khyA:
undetectable		 3lk0D-3khyA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		3 HIS A 355
PHE A 272
PHE A 273
 None
 0.72A 3lk0D-3lcaA:
undetectable		 3lk0D-3lcaA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		3 HIS A 881
PHE A 830
PHE A 805
 None
 0.64A 3lk0D-3n3kA:
0.1		 3lk0D-3n3kA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7p RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1

(Homo sapiens) 		PF04901
(RAMP) 		3 HIS D  75
PHE D  92
PHE D  93
 None
 0.74A 3lk0D-3n7pD:
undetectable		 3lk0D-3n7pD:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 HIS A  90
PHE A  49
PHE A  50
 None
 0.79A 3lk0D-3on7A:
undetectable		 3lk0D-3on7A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 HIS A 422
PHE A 483
PHE A 480
 None
 0.62A 3lk0D-3ptkA:
undetectable		 3lk0D-3ptkA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A

(Escherichia
coli) 		PF00004
(AAA)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		3 HIS A 116
PHE A 126
PHE A 137
 None
 0.79A 3lk0D-3pvsA:
1.6		 3lk0D-3pvsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis) 		PF00150
(Cellulase) 		3 HIS A 131
PHE A 148
PHE A 149
 None
 0.51A 3lk0D-3pzuA:
undetectable		 3lk0D-3pzuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		3 HIS A 198
PHE A 293
PHE A 294
 None
 0.76A 3lk0D-3q9cA:
undetectable		 3lk0D-3q9cA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		3 HIS A 432
PHE A 454
PHE A 455
 None
 0.75A 3lk0D-3qkiA:
0.8		 3lk0D-3qkiA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbj ACTIBIND

(Aspergillus
niger) 		PF00445
(Ribonuclease_T2) 		3 HIS A  74
PHE A 163
PHE A 162
 PO4  A 304 (-3.9A)
None
None
 0.58A 3lk0D-3tbjA:
0.3		 3lk0D-3tbjA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu B2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		3 HIS C  55
PHE C  37
PHE C  41
 None
 0.75A 3lk0D-3wcuC:
undetectable		 3lk0D-3wcuC:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 3 HIS A  53
PHE A 368
PHE A 369
 L6S  A1610 (-4.0A)
None
None
 0.68A 3lk0D-4aw7A:
undetectable		 3lk0D-4aw7A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS A 180
PHE A 363
PHE A 365
 None
 0.72A 3lk0D-4b99A:
undetectable		 3lk0D-4b99A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE

(Bacteroides
thetaiotaomicron) 		PF03372
(Exo_endo_phos) 		3 HIS A 205
PHE A 211
PHE A 251
 None
 0.70A 3lk0D-4c1rA:
undetectable		 3lk0D-4c1rA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 HIS A 444
PHE A 110
PHE A 111
 None
 0.68A 3lk0D-4dalA:
undetectable		 3lk0D-4dalA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		3 HIS A 683
PHE A 645
PHE A 646
 None
 0.54A 3lk0D-4dloA:
undetectable		 3lk0D-4dloA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		3 HIS A 228
PHE A 223
PHE A 255
 None
 0.77A 3lk0D-4efhA:
undetectable		 3lk0D-4efhA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		3 HIS B 249
PHE B 239
PHE B 238
 None
 0.71A 3lk0D-4gmjB:
undetectable		 3lk0D-4gmjB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		3 HIS A 113
PHE A 148
PHE A 149
 None
 0.72A 3lk0D-4kfvA:
undetectable		 3lk0D-4kfvA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		3 HIS A 199
PHE A 148
PHE A 149
 None
 0.50A 3lk0D-4kfvA:
undetectable		 3lk0D-4kfvA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		3 HIS A  97
PHE A 111
PHE A 112
 TRS  A 301 (-3.9A)
None
None
 0.45A 3lk0D-4m1rA:
undetectable		 3lk0D-4m1rA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n40 PROTEIN ECT2

(Homo sapiens) 		PF00533
(BRCT)
PF12738
(PTCB-BRCT) 		3 HIS A 169
PHE A 102
PHE A 107
 None
 0.71A 3lk0D-4n40A:
undetectable		 3lk0D-4n40A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzk UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		PF14286
(DHHW) 		3 HIS A 194
PHE A 251
PHE A 230
 UNL  A 404 ( 3.1A)
None
None
 0.79A 3lk0D-4nzkA:
undetectable		 3lk0D-4nzkA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 HIS A 205
PHE A 199
PHE A 581
 None
 0.63A 3lk0D-4ph9A:
1.0		 3lk0D-4ph9A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		3 HIS A 207
PHE A 176
PHE A 177
 None
 0.78A 3lk0D-4pxlA:
undetectable		 3lk0D-4pxlA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 PUTATIVE CYSTINE
PROTEASE

(Pseudomonas
fluorescens) 		PF06035
(Peptidase_C93) 		3 HIS E 148
PHE E 101
PHE E 102
 None
 0.66A 3lk0D-4u65E:
undetectable		 3lk0D-4u65E:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 HIS A 106
PHE A 241
PHE A 242
 None
 0.77A 3lk0D-4uzuA:
undetectable		 3lk0D-4uzuA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 HIS A 323
PHE A 317
PHE A 266
 None
 0.59A 3lk0D-4v2xA:
undetectable		 3lk0D-4v2xA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 HIS A 949
PHE A 961
PHE A 962
 None
 0.63A 3lk0D-4xgtA:
undetectable		 3lk0D-4xgtA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		3 HIS A 165
PHE A 243
PHE A 248
 None
 0.65A 3lk0D-4xjxA:
undetectable		 3lk0D-4xjxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 HIS A 104
PHE A 121
PHE A 122
 None
 0.48A 3lk0D-4xzbA:
0.3		 3lk0D-4xzbA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(Geobacillus sp.
70PC53;
uncultured
bacterium) 		PF00150
(Cellulase) 		3 HIS A 104
PHE A 121
PHE A 122
 None
 0.39A 3lk0D-4xzwA:
undetectable		 3lk0D-4xzwA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y26 GALECTIN-7

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 HIS A  33
PHE A  80
PHE A  86
 None
 0.76A 3lk0D-4y26A:
undetectable		 3lk0D-4y26A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		3 HIS A 191
PHE A 203
PHE A 225
 None
 0.78A 3lk0D-5ccxA:
undetectable		 3lk0D-5ccxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 HIS A 949
PHE A 961
PHE A 962
 None
 0.71A 3lk0D-5e02A:
undetectable		 3lk0D-5e02A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e04 NUCLEOPROTEIN

(Andes
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		3 HIS A 394
PHE A 331
PHE A 330
 None
 0.41A 3lk0D-5e04A:
undetectable		 3lk0D-5e04A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e05 NUCLEOCAPSID PROTEIN

(Sin Nombre
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		3 HIS A 394
PHE A 331
PHE A 330
 None
 0.37A 3lk0D-5e05A:
undetectable		 3lk0D-5e05A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 HIS A 298
PHE A 292
PHE A 241
 None
 0.59A 3lk0D-5e0cA:
undetectable		 3lk0D-5e0cA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 HIS A 149
PHE A 167
PHE A 168
 None
 0.58A 3lk0D-5ecuA:
undetectable		 3lk0D-5ecuA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 HIS A 153
PHE A 171
PHE A 172
 None
 0.52A 3lk0D-5fipA:
undetectable		 3lk0D-5fipA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		3 HIS A 301
PHE A 369
PHE A 452
 None
 0.67A 3lk0D-5fx8A:
undetectable		 3lk0D-5fx8A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF14382
(ECR1_N)
PF15985
(KH_6) 		3 HIS B 127
PHE E  40
PHE H  14
 None
 0.79A 3lk0D-5g06B:
undetectable		 3lk0D-5g06B:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		3 HIS A  88
PHE A 164
PHE A 157
 ACT  A 402 (-4.2A)
PG4  A 401 ( 4.1A)
PG4  A 401 (-3.6A)
 0.79A 3lk0D-5hx0A:
undetectable		 3lk0D-5hx0A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		3 HIS A 110
PHE A 122
PHE A 123
 GOL  A 402 (-4.2A)
None
None
 0.58A 3lk0D-5i2uA:
undetectable		 3lk0D-5i2uA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		3 HIS A 124
PHE A 138
PHE A 139
 None
 0.57A 3lk0D-5ihsA:
undetectable		 3lk0D-5ihsA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 HIS A 204
PHE A 198
PHE A 580
 None
 0.69A 3lk0D-5ikrA:
undetectable		 3lk0D-5ikrA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		3 HIS A 290
PHE A 248
PHE A 249
 None
 0.57A 3lk0D-5ipxA:
undetectable		 3lk0D-5ipxA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it3 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF04433
(SWIRM) 		3 HIS A 253
PHE A 210
PHE A 196
 None
 0.71A 3lk0D-5it3A:
undetectable		 3lk0D-5it3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		3 HIS A 253
PHE A  66
PHE A 192
 None
 0.74A 3lk0D-5jp9A:
undetectable		 3lk0D-5jp9A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 HIS A 253
PHE A 210
PHE A 196
 None
 0.76A 3lk0D-5l3dA:
undetectable		 3lk0D-5l3dA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 HIS A 899
PHE A 954
PHE A 956
 None
 0.72A 3lk0D-5l56A:
undetectable		 3lk0D-5l56A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7n PLEXIN-A1

(Mus musculus) 		PF01833
(TIG) 		3 HIS A 899
PHE A 954
PHE A 956
 None
 0.72A 3lk0D-5l7nA:
undetectable		 3lk0D-5l7nA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		3 HIS A  56
PHE A  46
PHE A  44
 None
 0.72A 3lk0D-5lfrA:
undetectable		 3lk0D-5lfrA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		3 HIS A 396
PHE A 365
PHE A 364
 None
 0.77A 3lk0D-5lv9A:
undetectable		 3lk0D-5lv9A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9b INTERLEUKIN-17
RECEPTOR A

(Homo sapiens) 		no annotation 3 HIS A  38
PHE A 149
PHE A 146
 None
 0.65A 3lk0D-5n9bA:
undetectable		 3lk0D-5n9bA:
20.00