SIMILAR PATTERNS OF AMINO ACIDS FOR 3LFA_A_1N1A361_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  54
LYS A  56
GLU A  74
LEU A 107
MET A 112
 ANP  A 400 ( 4.9A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
None
None
 0.50A 3lfaA-1cm8A:
35.6		 3lfaA-1cm8A:
61.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 VAL A   8
ALA A  66
THR A  23
LEU A  25
 None
 0.44A 3lfaA-1ffvA:
undetectable		 3lfaA-1ffvA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
LYS A 222
GLU A 236
THR A 266
MET A 269
 None
 0.52A 3lfaA-1k9aA:
20.2		 3lfaA-1k9aA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 VAL A  45
LYS A  68
GLU A  81
LEU A 111
 HNA  A 351 (-4.3A)
HNA  A 351 (-2.6A)
None
None
 0.29A 3lfaA-1m2pA:
24.8		 3lfaA-1m2pA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 288
LYS A 290
GLU A 305
THR A 334
MET A 337
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
 0.45A 3lfaA-1opkA:
19.7		 3lfaA-1opkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 621
LYS A 623
GLU A 640
THR A 670
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
 0.40A 3lfaA-1t46A:
9.0		 3lfaA-1t46A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  36
LYS A  38
GLU A  55
LEU A  82
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.28A 3lfaA-1zltA:
21.4		 3lfaA-1zltA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 None
 0.53A 3lfaA-1zwsA:
22.3		 3lfaA-1zwsA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 GOL  A3001 (-3.5A)
None
None
None
None
 0.40A 3lfaA-2a2aA:
21.8		 3lfaA-2a2aA:
29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  91
LYS A  93
LEU A 144
LEU A 148
MET A 149
 AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.39A 3lfaA-2b1pA:
34.3		 3lfaA-2b1pA:
48.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  60
LEU A  87
LEU A  91
 None
 0.39A 3lfaA-2bdwA:
22.0		 3lfaA-2bdwA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  47
LYS A  49
GLU A  65
LEU A  96
 STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
 0.33A 3lfaA-2bujA:
22.2		 3lfaA-2bujA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		5 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
 CKI  A 300 (-3.6A)
None
None
None
None
 0.76A 3lfaA-2csnA:
18.4		 3lfaA-2csnA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
LYS X  39
GLU X  54
THR X  82
MET X  85
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.1A)
None
 0.68A 3lfaA-2dq7X:
20.5		 3lfaA-2dq7X:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 184
LYS A 186
GLU A 201
LEU A 238
 None
 0.37A 3lfaA-2eu9A:
24.8		 3lfaA-2eu9A:
27.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  59
LEU A  95
MET A  96
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 4.9A)
None
 0.60A 3lfaA-2f9gA:
35.0		 3lfaA-2f9gA:
44.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
LYS A 273
GLU A 288
THR A 316
MET A 319
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.2A)
None
 0.70A 3lfaA-2hk5A:
20.4		 3lfaA-2hk5A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 269
LYS A 271
GLU A 286
THR A 315
MET A 318
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
 0.56A 3lfaA-2hz0A:
19.8		 3lfaA-2hz0A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
LYS A 273
GLU A 288
THR A 316
MET A 319
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
 0.56A 3lfaA-2og8A:
6.4		 3lfaA-2og8A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 449
LYS A 451
GLU A 463
THR A 493
LEU A 495
MET A 496
 None
 0.84A 3lfaA-2qr7A:
19.2		 3lfaA-2qr7A:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 749
LEU A 794
THR A 796
LEU A 798
MET A 799
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
 0.45A 3lfaA-2r4bA:
19.3		 3lfaA-2r4bA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 749
LYS A 751
THR A 796
LEU A 798
MET A 799
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
 0.61A 3lfaA-2r4bA:
19.3		 3lfaA-2r4bA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		4 ALA A 509
LYS A 511
GLU A 535
LEU A 603
 5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
None
 0.40A 3lfaA-2vuwA:
14.6		 3lfaA-2vuwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.46A 3lfaA-2w4kA:
21.9		 3lfaA-2w4kA:
29.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 445
GLU A 459
LEU A 487
THR A 489
LEU A 491
MET A 492
 None
 0.95A 3lfaA-2wntA:
15.1		 3lfaA-2wntA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LYS A 447
GLU A 459
LEU A 487
THR A 489
LEU A 491
MET A 492
 None
 0.94A 3lfaA-2wntA:
15.1		 3lfaA-2wntA:
30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  51
LEU A 105
LEU A 109
MET A 110
 B49  A1294 (-3.2A)
None
B49  A1294 ( 4.7A)
None
 0.29A 3lfaA-2y7jA:
23.6		 3lfaA-2y7jA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.50A 3lfaA-2yabA:
21.8		 3lfaA-2yabA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  41
GLU A  61
LEU A  88
LEU A  92
 5CP  A 600 (-3.6A)
None
None
5CP  A 600 (-4.6A)
 0.42A 3lfaA-3bhhA:
22.1		 3lfaA-3bhhA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
4RB  A 401 (-4.4A)
 0.53A 3lfaA-3bqrA:
21.2		 3lfaA-3bqrA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  31
ALA A  52
GLU A  72
LEU A 105
MET A 110
 None
 0.56A 3lfaA-3coiA:
38.8		 3lfaA-3coiA:
61.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
LYS A 222
GLU A 236
THR A 266
MET A 269
 None
 0.53A 3lfaA-3d7uA:
17.6		 3lfaA-3d7uA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  53
LYS A  55
GLU A  73
LEU A 106
LEU A 110
MET A 111
 35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
None
35F  A   1 (-4.5A)
None
 0.45A 3lfaA-3e7oA:
34.8		 3lfaA-3e7oA:
50.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  65
LYS A  67
GLU A  89
LEU A 118
 985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
 0.27A 3lfaA-3f2aA:
20.4		 3lfaA-3f2aA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ALA A  55
LYS A  57
LEU A 100
LEU A 104
 DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 (-4.4A)
 0.34A 3lfaA-3f3zA:
19.3		 3lfaA-3f3zA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  51
GLU A  71
LEU A 104
LEU A 108
MET A 109
 None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
None
 0.72A 3lfaA-3gp0A:
40.5		 3lfaA-3gp0A:
75.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  51
GLU A  71
LEU A 104
THR A 106
LEU A 108
 None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
 0.50A 3lfaA-3gp0A:
40.5		 3lfaA-3gp0A:
75.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 453
GLU A 468
LEU A 496
LEU A 500
 ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.6A)
 0.41A 3lfaA-3kn5A:
17.8		 3lfaA-3kn5A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
LYS A 667
GLU A 684
THR A 713
MET A 716
 None
 0.52A 3lfaA-3kulA:
21.1		 3lfaA-3kulA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ALA A 579
LYS A 581
GLU A 596
LEU A 628
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
 0.32A 3lfaA-3lltA:
23.4		 3lfaA-3lltA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 719
LEU A 764
THR A 766
LEU A 768
MET A 769
 ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
 0.82A 3lfaA-3lzbA:
19.2		 3lfaA-3lzbA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 719
LYS A 721
LEU A 764
THR A 766
LEU A 768
 ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
 0.44A 3lfaA-3lzbA:
19.2		 3lfaA-3lzbA:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  46
LYS A  48
GLU A  66
LEU A 101
 None
 0.31A 3lfaA-3mi9A:
22.0		 3lfaA-3mi9A:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ALA A  49
LYS A  51
GLU A  69
LEU A  96
MET A 101
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
 0.62A 3lfaA-3nizA:
27.9		 3lfaA-3nizA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  29
ALA A  49
LYS A  51
GLU A  69
LEU A  96
 None
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
 0.48A 3lfaA-3nizA:
27.9		 3lfaA-3nizA:
33.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
 0.73A 3lfaA-3nyoA:
22.7		 3lfaA-3nyoA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  31
ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
LEU A 109
MET A 110
 1N1  A1000 ( 4.3A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
None
 0.47A 3lfaA-3ohtA:
15.7		 3lfaA-3ohtA:
84.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		5 ALA A  49
LYS A  51
LEU A 110
THR A 112
LEU A 114
 None
 0.37A 3lfaA-3pg1A:
33.9		 3lfaA-3pg1A:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 751
LEU A 796
THR A 798
LEU A 800
MET A 801
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
None
 0.39A 3lfaA-3pp0A:
10.3		 3lfaA-3pp0A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 751
LYS A 753
LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.53A 3lfaA-3pp0A:
10.3		 3lfaA-3pp0A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.63A 3lfaA-3q5iA:
22.3		 3lfaA-3q5iA:
26.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  10
ALA A  31
LYS A  33
GLU A  50
LEU A  77
 38R  A 350 (-4.4A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.52A 3lfaA-3zduA:
25.3		 3lfaA-3zduA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  80
LYS A  82
GLU A 101
LEU A 132
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
 0.43A 3lfaA-4a4lA:
19.1		 3lfaA-4a4lA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  31
LYS A  33
GLU A  51
LEU A  78
 D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
 0.32A 3lfaA-4aguA:
27.4		 3lfaA-4aguA:
30.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ALA A 104
LYS A 106
GLU A 125
LEU A 152
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
 0.36A 3lfaA-4aw2A:
21.8		 3lfaA-4aw2A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 VAL A 214
ALA A 233
LYS A 235
THR A 283
 TAK  A1507 ( 4.3A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
 0.43A 3lfaA-4c02A:
18.8		 3lfaA-4c02A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 653
LYS A 655
GLU A 672
THR A 701
MET A 704
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
 0.53A 3lfaA-4ckrA:
21.0		 3lfaA-4ckrA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 ALA A  64
LYS A  66
GLU A  78
LEU A 111
 None
 0.42A 3lfaA-4e7wA:
27.5		 3lfaA-4e7wA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A  36
LYS A  38
GLU A  55
LEU A  84
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
 0.34A 3lfaA-4euuA:
16.5		 3lfaA-4euuA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A  46
LYS A  69
GLU A  82
LEU A 150
 GNP  A 401 (-4.2A)
GNP  A 401 (-3.3A)
None
None
 0.33A 3lfaA-4jr7A:
23.3		 3lfaA-4jr7A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  49
LYS A  51
LEU A  93
THR A  95
MET A  98
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 0.42A 3lfaA-4m69A:
19.4		 3lfaA-4m69A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  28
ALA A  49
LEU A  93
THR A  95
MET A  98
 ANP  A 401 (-4.7A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
None
 0.56A 3lfaA-4m69A:
19.4		 3lfaA-4m69A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 ALA A 218
LYS A 220
GLU A 239
LEU A 273
MET A 274
 29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
None
 0.99A 3lfaA-4mk0A:
22.9		 3lfaA-4mk0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  99
LYS A 101
GLU A 117
LEU A 144
LEU A 148
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.3A)
 0.59A 3lfaA-4mvfA:
19.2		 3lfaA-4mvfA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  67
LYS A  69
GLU A  85
LEU A 121
THR A 123
LEU A 125
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.8A)
 0.37A 3lfaA-4o38A:
17.8		 3lfaA-4o38A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 248
THR A 301
LEU A 303
MET A 304
 None
 0.38A 3lfaA-4pwnA:
20.8		 3lfaA-4pwnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ALA A 213
LYS A 215
GLU A 234
LEU A 261
 SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
 0.28A 3lfaA-4tnbA:
20.7		 3lfaA-4tnbA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B  51
LYS B  53
THR B 106
LEU B 108
MET B 109
 39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.61A 3lfaA-4tyhB:
42.6		 3lfaA-4tyhB:
99.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B  30
ALA B  51
LEU B 104
THR B 106
LEU B 108
MET B 109
 None
39G  B 401 (-3.5A)
39G  B 401 ( 4.7A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.54A 3lfaA-4tyhB:
42.6		 3lfaA-4tyhB:
99.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
 ANW  A 601 (-3.4A)
None
None
None
None
 0.72A 3lfaA-4wboA:
19.1		 3lfaA-4wboA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ALA A  50
LYS A  52
GLU A  69
LEU A 105
MET A 106
 42A  A 402 (-3.2A)
42A  A 402 (-4.1A)
None
42A  A 402 ( 4.9A)
None
 0.89A 3lfaA-4xrlA:
36.4		 3lfaA-4xrlA:
46.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 488
LYS A 490
GLU A 509
THR A 539
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
 0.43A 3lfaA-4yffA:
19.1		 3lfaA-4yffA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
 AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.63A 3lfaA-4yhjA:
20.1		 3lfaA-4yhjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 186
LYS A 188
GLU A 203
LEU A 236
 4E1  A 505 (-3.5A)
4E1  A 505 (-2.7A)
None
None
 0.38A 3lfaA-4yljA:
24.7		 3lfaA-4yljA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.59A 3lfaA-4ysjA:
20.7		 3lfaA-4ysjA:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  51
LYS A  53
LEU A 104
LEU A 108
MET A 109
 ANP  A 401 (-3.5A)
ANP  A 401 (-2.9A)
None
ANP  A 401 ( 4.8A)
None
 0.32A 3lfaA-5awmA:
35.4		 3lfaA-5awmA:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ALA A  90
LYS A  92
GLU A 110
LEU A 146
MET A 147
 None
 0.86A 3lfaA-5ci6A:
34.7		 3lfaA-5ci6A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  31
ALA A  52
LYS A  54
GLU A  69
LEU A 103
 VAL  A  31 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A 103 ( 0.6A)
 0.57A 3lfaA-5d7aA:
22.0		 3lfaA-5d7aA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 250
ALA A 275
LYS A 277
GLU A 290
LEU A 323
THR A 325
 STU  A 601 (-3.9A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.7A)
 0.56A 3lfaA-5e8yA:
19.2		 3lfaA-5e8yA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA C  44
LYS C  46
GLU C  60
LEU C  88
LEU C  92
 None
 0.87A 3lfaA-5fqdC:
17.7		 3lfaA-5fqdC:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ALA A 625
LYS A 627
GLU A 644
THR A 674
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
 0.33A 3lfaA-5grnA:
19.9		 3lfaA-5grnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl4 RING-HYDROXYLATING
DIOXYGENASE

(Sinorhizobium
meliloti) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 VAL A 334
ALA A 280
LEU A 271
THR A 274
LEU A 349
 None
 1.27A 3lfaA-5hl4A:
undetectable		 3lfaA-5hl4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
 ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
 0.43A 3lfaA-5hu3A:
22.7		 3lfaA-5hu3A:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		5 ALA A 356
LYS A 358
GLU A 411
LEU A 443
LEU A 447
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
None
ANP  A 700 ( 4.5A)
 0.87A 3lfaA-5i35A:
4.0		 3lfaA-5i35A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		5 ALA A 356
LYS A 358
GLU A 411
THR A 445
LEU A 447
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
ANP  A 700 (-4.1A)
ANP  A 700 ( 4.5A)
 0.66A 3lfaA-5i35A:
4.0		 3lfaA-5i35A:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  50
LYS A  52
GLU A  66
LEU A  95
 6A7  A 401 (-4.7A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
None
 0.56A 3lfaA-5idnA:
10.7		 3lfaA-5idnA:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		4 ALA A  45
LYS A  47
GLU A  65
LEU A  92
 None
 0.41A 3lfaA-5ig1A:
22.5		 3lfaA-5ig1A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 743
LYS A 745
GLU A 762
LEU A 788
LEU A 792
MET A 793
 6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
 0.61A 3lfaA-5j9zA:
20.6		 3lfaA-5j9zA:
25.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 417
LYS A 419
GLU A 436
LEU A 463
LEU A 467
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
 0.61A 3lfaA-5jznA:
23.4		 3lfaA-5jznA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ALA A 909
LYS A 911
LEU A 954
MET A 959
 ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
 0.37A 3lfaA-5lpyA:
17.9		 3lfaA-5lpyA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 ALA A 909
LYS A 911
LEU A 954
MET A 959
 ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
 0.40A 3lfaA-5lpzA:
17.9		 3lfaA-5lpzA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 ALA A  65
LYS A  67
GLU A  89
LEU A 118
 7LK  A 401 (-3.3A)
None
None
None
 0.28A 3lfaA-5turA:
20.7		 3lfaA-5turA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ALA A 218
LYS A 220
GLU A 239
LEU A 273
MET A 274
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
MES  A 604 (-3.9A)
 0.77A 3lfaA-5uuuA:
23.1		 3lfaA-5uuuA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 137
LYS A 139
GLU A 157
LEU A 185
LEU A 189
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
None
 1.07A 3lfaA-5vcxA:
22.1		 3lfaA-5vcxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
 0.83A 3lfaA-5vcxA:
22.1		 3lfaA-5vcxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 VAL A  28
ALA A  49
GLU A  69
LEU A  94
MET A  99
 VX6  A 402 ( 4.2A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
None
None
 0.68A 3lfaA-5wnmA:
20.6		 3lfaA-5wnmA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ALA A  70
LYS A  72
GLU A  85
LEU A 115
 ATP  A 403 (-3.4A)
ATP  A 403 (-3.2A)
None
None
 0.28A 3lfaA-5xvuA:
24.7		 3lfaA-5xvuA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A  40
LYS A  42
GLU A  61
LEU A  97
 CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
 0.43A 3lfaA-6b2qA:
22.4		 3lfaA-6b2qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 ALA A 754
LYS A 756
GLU A 774
LEU A 811
MET A 816
 CJM  A1102 (-3.1A)
None
None
None
None
 0.51A 3lfaA-6b3eA:
26.9		 3lfaA-6b3eA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 ALA A 155
LYS A 157
LEU A 228
LEU A 232
 H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
None
H1N  A 501 (-4.3A)
 0.42A 3lfaA-6ccfA:
21.5		 3lfaA-6ccfA:
11.17