SIMILAR PATTERNS OF AMINO ACIDS FOR 3L8L_D_DVAD8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		3 VAL A 227
VAL A 213
TRP A 215
 None
 0.96A 3l8lC-1bqyA:
undetectable
3l8lD-1bqyA:
undetectable		 3l8lC-1bqyA:
7.01
3l8lD-1bqyA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 VAL A 240
VAL A 236
TRP A 391
 None
 0.92A 3l8lC-1clwA:
undetectable
3l8lD-1clwA:
undetectable		 3l8lC-1clwA:
2.32
3l8lD-1clwA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 VAL C 227
VAL C 213
TRP C 215
 None
 0.97A 3l8lC-1eptC:
undetectable
3l8lD-1eptC:
undetectable		 3l8lC-1eptC:
14.81
3l8lD-1eptC:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL A 227
VAL A 213
TRP A 215
 None
 0.96A 3l8lC-1fxyA:
undetectable
3l8lD-1fxyA:
undetectable		 3l8lC-1fxyA:
5.94
3l8lD-1fxyA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		3 VAL T 227
VAL T 213
TRP T 215
 None
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
 0.95A 3l8lC-1j17T:
undetectable
3l8lD-1j17T:
undetectable		 3l8lC-1j17T:
5.12
3l8lD-1j17T:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		3 VAL H 227
VAL H 213
TRP H 215
 None
 0.97A 3l8lC-1kigH:
undetectable
3l8lD-1kigH:
undetectable		 3l8lC-1kigH:
5.85
3l8lD-1kigH:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 VAL A 464
VAL A 466
TRP A 313
 None
 0.84A 3l8lC-1m1cA:
undetectable
3l8lD-1m1cA:
undetectable		 3l8lC-1m1cA:
1.76
3l8lD-1m1cA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL H 227
VAL H 213
TRP H 215
 None
CR9  H 256 (-4.3A)
None
 0.95A 3l8lC-1o5fH:
undetectable
3l8lD-1o5fH:
undetectable		 3l8lC-1o5fH:
5.80
3l8lD-1o5fH:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 VAL G  69
VAL G  46
TRP G  44
 None
 0.87A 3l8lC-1rgiG:
undetectable
3l8lD-1rgiG:
undetectable		 3l8lC-1rgiG:
3.77
3l8lD-1rgiG:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO) 		3 VAL B  63
VAL B  61
TRP B  48
 None
 0.96A 3l8lC-1yewB:
undetectable
3l8lD-1yewB:
undetectable		 3l8lC-1yewB:
16.05
3l8lD-1yewB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B)
PF02461
(AMO) 		3 VAL B  91
VAL A 200
TRP B  87
 None
 0.61A 3l8lC-1yewB:
undetectable
3l8lD-1yewB:
undetectable		 3l8lC-1yewB:
16.05
3l8lD-1yewB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		3 VAL A 276
VAL A 278
TRP A 309
 None
 0.91A 3l8lC-1yleA:
undetectable
3l8lD-1yleA:
undetectable		 3l8lC-1yleA:
4.18
3l8lD-1yleA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 VAL A 464
VAL A 474
TRP A 557
 None
 0.66A 3l8lC-1yr2A:
undetectable
3l8lD-1yr2A:
undetectable		 3l8lC-1yr2A:
4.46
3l8lD-1yr2A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 VAL B 125
VAL B  38
TRP B 150
 None
 0.84A 3l8lC-2amcB:
undetectable
3l8lD-2amcB:
undetectable		 3l8lC-2amcB:
2.41
3l8lD-2amcB:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 VAL A 656
VAL A 688
TRP A 659
 None
 0.93A 3l8lC-2bucA:
undetectable
3l8lD-2bucA:
undetectable		 3l8lC-2bucA:
2.76
3l8lD-2bucA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cop ACYL-COENZYME A
BINDING DOMAIN
CONTAINING 6

(Homo sapiens) 		PF00887
(ACBP) 		3 VAL A  43
VAL A  41
TRP A  65
 None
 0.80A 3l8lC-2copA:
undetectable
3l8lD-2copA:
undetectable		 3l8lC-2copA:
13.43
3l8lD-2copA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK

(Mus musculus) 		PF00017
(SH2) 		3 VAL A  36
VAL A  49
TRP A  11
 None
 0.81A 3l8lC-2eu0A:
undetectable
3l8lD-2eu0A:
undetectable		 3l8lC-2eu0A:
4.59
3l8lD-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Bacillus
subtilis) 		PF02390
(Methyltransf_4) 		3 VAL A 103
VAL A 142
TRP A  31
 None
 0.97A 3l8lC-2fcaA:
undetectable
3l8lD-2fcaA:
undetectable		 3l8lC-2fcaA:
7.74
3l8lD-2fcaA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 VAL A 656
VAL A 688
TRP A 659
 None
 0.90A 3l8lC-2g5tA:
undetectable
3l8lD-2g5tA:
undetectable		 3l8lC-2g5tA:
3.81
3l8lD-2g5tA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1l EXPORTIN-1

(Homo sapiens) 		no annotation 3 VAL B 604
VAL B 602
TRP B 559
 None
 0.90A 3l8lC-2l1lB:
undetectable
3l8lD-2l1lB:
undetectable		 3l8lC-2l1lB:
12.28
3l8lD-2l1lB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2

(Homo sapiens) 		PF08210
(APOBEC_N) 		3 VAL A 192
VAL A 187
TRP A 188
 None
 0.94A 3l8lC-2nytA:
undetectable
3l8lD-2nytA:
undetectable		 3l8lC-2nytA:
6.90
3l8lD-2nytA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 VAL A 657
VAL A 689
TRP A 660
 None
 0.92A 3l8lC-2oaeA:
undetectable
3l8lD-2oaeA:
undetectable		 3l8lC-2oaeA:
2.25
3l8lD-2oaeA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SAH  A 301 (-3.8A)
None
None
 0.85A 3l8lC-2oy0A:
undetectable
3l8lD-2oy0A:
undetectable		 3l8lC-2oy0A:
6.78
3l8lD-2oy0A:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4q UPF0366 PROTEIN
C11ORF67

(Homo sapiens) 		PF04430
(DUF498) 		3 VAL A  57
VAL A 114
TRP A  29
 None
 0.95A 3l8lC-2q4qA:
undetectable
3l8lD-2q4qA:
undetectable		 3l8lC-2q4qA:
8.41
3l8lD-2q4qA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		3 VAL A 606
VAL A 656
TRP A 602
 None
 0.85A 3l8lC-2qr7A:
undetectable
3l8lD-2qr7A:
undetectable		 3l8lC-2qr7A:
4.68
3l8lD-2qr7A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r63 REPRESSOR PROTEIN
FROM BACTERIOPHAGE
434

(Escherichia
virus Lambda) 		PF01381
(HTH_3) 		3 VAL A  54
VAL A  56
TRP A  58
 None
 0.93A 3l8lC-2r63A:
undetectable
3l8lD-2r63A:
undetectable		 3l8lC-2r63A:
19.51
3l8lD-2r63A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rso CHROMATIN-ASSOCIATED
PROTEIN SWI6

(Schizosaccharomyces
pombe) 		PF00385
(Chromo) 		3 VAL A  83
VAL A  86
TRP A 104
 None
 0.96A 3l8lC-2rsoA:
undetectable
3l8lD-2rsoA:
undetectable		 3l8lC-2rsoA:
10.84
3l8lD-2rsoA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		3 VAL A  98
VAL A 160
TRP A 172
 None
 0.88A 3l8lC-2uwfA:
undetectable
3l8lD-2uwfA:
undetectable		 3l8lC-2uwfA:
3.53
3l8lD-2uwfA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		3 VAL A 251
VAL A 246
TRP A 271
 None
 0.90A 3l8lC-2vreA:
undetectable
3l8lD-2vreA:
undetectable		 3l8lC-2vreA:
9.76
3l8lD-2vreA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysq RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9

(Homo sapiens) 		PF00018
(SH3_1) 		3 VAL A  34
VAL A  62
TRP A  65
 None
 0.96A 3l8lC-2ysqA:
undetectable
3l8lD-2ysqA:
undetectable		 3l8lC-2ysqA:
19.64
3l8lD-2ysqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 VAL A  51
VAL A  49
TRP A  79
 None
 0.94A 3l8lC-3c87A:
undetectable
3l8lD-3c87A:
undetectable		 3l8lC-3c87A:
3.61
3l8lD-3c87A:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di5 DINB-LIKE PROTEIN

(Bacillus cereus) 		PF05163
(DinB) 		3 VAL A  50
VAL A  45
TRP A  47
 None
 0.88A 3l8lC-3di5A:
undetectable
3l8lD-3di5A:
undetectable		 3l8lC-3di5A:
9.17
3l8lD-3di5A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		3 VAL A 305
VAL A 308
TRP A 295
 None
 0.84A 3l8lC-3e7gA:
undetectable
3l8lD-3e7gA:
undetectable		 3l8lC-3e7gA:
2.91
3l8lD-3e7gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		3 VAL A 166
VAL A 164
TRP A 191
 None
 0.95A 3l8lC-3e96A:
undetectable
3l8lD-3e96A:
undetectable		 3l8lC-3e96A:
4.56
3l8lD-3e96A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f65 CHAPERONE PROTEIN
FAEE

(Escherichia
coli) 		PF00345
(PapD_N) 		3 VAL A  82
VAL A  41
TRP A  84
 None
 0.95A 3l8lC-3f65A:
undetectable
3l8lD-3f65A:
undetectable		 3l8lC-3f65A:
4.93
3l8lD-3f65A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 VAL A 273
VAL A  71
TRP A  95
 None
 0.85A 3l8lC-3gwqA:
undetectable
3l8lD-3gwqA:
undetectable		 3l8lC-3gwqA:
3.82
3l8lD-3gwqA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		3 VAL A  41
VAL A 234
TRP A  43
 None
 0.49A 3l8lC-3irvA:
undetectable
3l8lD-3irvA:
undetectable		 3l8lC-3irvA:
9.78
3l8lD-3irvA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb5 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 72

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 VAL A 361
VAL A 335
TRP A 347
 None
 0.96A 3l8lC-3kb5A:
undetectable
3l8lD-3kb5A:
undetectable		 3l8lC-3kb5A:
7.74
3l8lD-3kb5A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkj CD40 LIGAND

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 239
VAL A 237
TRP A 140
 None
 0.60A 3l8lC-3lkjA:
undetectable
3l8lD-3lkjA:
undetectable		 3l8lC-3lkjA:
4.96
3l8lD-3lkjA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SFG  A 301 (-4.1A)
None
None
 0.77A 3l8lC-3lkzA:
undetectable
3l8lD-3lkzA:
undetectable		 3l8lC-3lkzA:
4.30
3l8lD-3lkzA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		3 VAL A 217
VAL A 213
TRP A 208
 None
 0.95A 3l8lC-3lubA:
undetectable
3l8lD-3lubA:
undetectable		 3l8lC-3lubA:
4.82
3l8lD-3lubA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 VAL A  52
VAL A  50
TRP A  80
 None
 0.91A 3l8lC-3mgaA:
undetectable
3l8lD-3mgaA:
undetectable		 3l8lC-3mgaA:
3.23
3l8lD-3mgaA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 VAL A 256
VAL A 251
TRP A 253
 None
 0.92A 3l8lC-3mjfA:
undetectable
3l8lD-3mjfA:
undetectable		 3l8lC-3mjfA:
3.80
3l8lD-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 VAL A 342
VAL A 352
TRP A 143
 None
 0.58A 3l8lC-3nlcA:
undetectable
3l8lD-3nlcA:
undetectable		 3l8lC-3nlcA:
2.41
3l8lD-3nlcA:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq2 CRISPR-ASSOCIATED
PROTEIN CAS2

(Desulfovibrio
vulgaris) 		PF09827
(CRISPR_Cas2) 		3 VAL A  48
VAL A   9
TRP A  81
 None
 0.90A 3l8lC-3oq2A:
undetectable
3l8lD-3oq2A:
undetectable		 3l8lC-3oq2A:
11.70
3l8lD-3oq2A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A 351
VAL A 349
TRP A  28
 None
 0.72A 3l8lC-3t8qA:
undetectable
3l8lD-3t8qA:
undetectable		 3l8lC-3t8qA:
8.14
3l8lD-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		3 VAL A  53
VAL A  37
TRP A  62
 None
None
CXS  A 171 (-4.4A)
 0.68A 3l8lC-3tfzA:
undetectable
3l8lD-3tfzA:
undetectable		 3l8lC-3tfzA:
11.00
3l8lD-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 VAL A1888
VAL A1883
TRP A1823
 None
 0.90A 3l8lC-3vkgA:
undetectable
3l8lD-3vkgA:
undetectable		 3l8lC-3vkgA:
1.24
3l8lD-3vkgA:
1.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 VAL A 744
VAL A 588
TRP A 591
 None
 0.92A 3l8lC-3vuoA:
undetectable
3l8lD-3vuoA:
undetectable		 3l8lC-3vuoA:
1.30
3l8lD-3vuoA:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		3 VAL A 166
VAL A 164
TRP A  64
 None
ADE  A 301 (-3.8A)
None
 0.95A 3l8lC-3wazA:
undetectable
3l8lD-3wazA:
undetectable		 3l8lC-3wazA:
5.35
3l8lD-3wazA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 VAL A 446
VAL A 449
TRP A 458
 None
 0.97A 3l8lC-4a4zA:
undetectable
3l8lD-4a4zA:
undetectable		 3l8lC-4a4zA:
1.31
3l8lD-4a4zA:
1.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 VAL A 690
VAL A 685
TRP A 659
 None
 0.91A 3l8lC-4av6A:
undetectable
3l8lD-4av6A:
undetectable		 3l8lC-4av6A:
3.69
3l8lD-4av6A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		3 VAL A 140
VAL A 135
TRP A  77
 None
 0.93A 3l8lC-4bptA:
undetectable
3l8lD-4bptA:
undetectable		 3l8lC-4bptA:
10.84
3l8lD-4bptA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8j MACRODOMAIN TER
PROTEIN

(Escherichia
coli) 		no annotation 3 VAL B  19
VAL B  41
TRP B  15
 None
 0.94A 3l8lC-4d8jB:
undetectable
3l8lD-4d8jB:
undetectable		 3l8lC-4d8jB:
13.10
3l8lD-4d8jB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dci UNCHARACTERIZED
PROTEIN

(Synechococcus
sp. WH 8102) 		PF11068
(YlqD) 		3 VAL A 109
VAL A 135
TRP A  23
 None
 0.97A 3l8lC-4dciA:
undetectable
3l8lD-4dciA:
undetectable		 3l8lC-4dciA:
16.00
3l8lD-4dciA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		3 VAL A 339
VAL A 361
TRP A 334
 None
 0.89A 3l8lC-4ftdA:
undetectable
3l8lD-4ftdA:
undetectable		 3l8lC-4ftdA:
2.43
3l8lD-4ftdA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL H 668
VAL H 653
TRP H 655
 None
 0.89A 3l8lC-4fxgH:
undetectable
3l8lD-4fxgH:
undetectable		 3l8lC-4fxgH:
5.45
3l8lD-4fxgH:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H  20
VAL H  82
TRP H  36
 None
 0.92A 3l8lC-4hfuH:
undetectable
3l8lD-4hfuH:
undetectable		 3l8lC-4hfuH:
8.85
3l8lD-4hfuH:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 VAL A 260
VAL A 348
TRP A 358
 None
 0.94A 3l8lC-4hjlA:
undetectable
3l8lD-4hjlA:
undetectable		 3l8lC-4hjlA:
4.48
3l8lD-4hjlA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igv KIROLA

(Actinidia
deliciosa) 		PF00407
(Bet_v_1) 		3 VAL A 103
VAL A 105
TRP A 116
 None
 0.81A 3l8lC-4igvA:
undetectable
3l8lD-4igvA:
undetectable		 3l8lC-4igvA:
8.08
3l8lD-4igvA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 101
VAL H  34
TRP H 101
 None
 0.88A 3l8lC-4k3dH:
undetectable
3l8lD-4k3dH:
undetectable		 3l8lC-4k3dH:
5.62
3l8lD-4k3dH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 217
VAL A 215
TRP A 114
 None
 0.74A 3l8lC-4kg8A:
undetectable
3l8lD-4kg8A:
undetectable		 3l8lC-4kg8A:
11.21
3l8lD-4kg8A:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		3 VAL A 305
VAL A 314
TRP A 202
 None
HEM  A 400 ( 4.9A)
None
 0.57A 3l8lC-4mf9A:
undetectable
3l8lD-4mf9A:
undetectable		 3l8lC-4mf9A:
4.30
3l8lD-4mf9A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		3 VAL A  41
VAL A  69
TRP A  72
 None
 0.94A 3l8lC-4mt6A:
undetectable
3l8lD-4mt6A:
undetectable		 3l8lC-4mt6A:
6.01
3l8lD-4mt6A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51

(Mus musculus) 		PF03281
(Mab-21) 		3 VAL A 262
VAL A 252
TRP A 337
 None
 0.77A 3l8lC-4oahA:
undetectable
3l8lD-4oahA:
undetectable		 3l8lC-4oahA:
3.75
3l8lD-4oahA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		3 VAL A  38
VAL A 180
TRP A  96
 None
 0.96A 3l8lC-4qb7A:
undetectable
3l8lD-4qb7A:
undetectable		 3l8lC-4qb7A:
4.10
3l8lD-4qb7A:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uiq GLOBIN-COUPLED
SENSOR WITH
DIGUANYLATE CYCLASE
ACTIVITY

(Bordetella
pertussis) 		PF11563
(Protoglobin) 		3 VAL A  76
VAL A  89
TRP A  72
 None
None
HEM  A 200 (-3.2A)
 0.70A 3l8lC-4uiqA:
undetectable
3l8lD-4uiqA:
undetectable		 3l8lC-4uiqA:
15.69
3l8lD-4uiqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		3 VAL A 622
VAL A 522
TRP A 674
 None
 0.89A 3l8lC-4uw2A:
undetectable
3l8lD-4uw2A:
undetectable		 3l8lC-4uw2A:
2.18
3l8lD-4uw2A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 VAL A 269
VAL A 105
TRP A  96
 None
 0.90A 3l8lC-4v1uA:
undetectable
3l8lD-4v1uA:
undetectable		 3l8lC-4v1uA:
2.94
3l8lD-4v1uA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 232
VAL A 230
TRP A 208
 None
None
NAP  A 501 ( 4.8A)
 0.92A 3l8lC-4y1bA:
undetectable
3l8lD-4y1bA:
undetectable		 3l8lC-4y1bA:
4.78
3l8lD-4y1bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 VAL C 340
VAL C 335
TRP C 550
 None
 0.95A 3l8lC-4yfaC:
undetectable
3l8lD-4yfaC:
undetectable		 3l8lC-4yfaC:
3.66
3l8lD-4yfaC:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		3 VAL A 332
VAL A 360
TRP A 143
 None
 0.96A 3l8lC-4zasA:
undetectable
3l8lD-4zasA:
undetectable		 3l8lC-4zasA:
3.59
3l8lD-4zasA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cze PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL B  81
VAL B  79
TRP B   6
 None
 0.82A 3l8lC-5czeB:
undetectable
3l8lD-5czeB:
undetectable		 3l8lC-5czeB:
17.95
3l8lD-5czeB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL C  81
VAL C  79
TRP C   6
 None
 0.88A 3l8lC-5czfC:
undetectable
3l8lD-5czfC:
undetectable		 3l8lC-5czfC:
14.29
3l8lD-5czfC:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 3 VAL A 194
VAL A 196
TRP A 272
 None
 0.79A 3l8lC-5dmuA:
undetectable
3l8lD-5dmuA:
undetectable		 3l8lC-5dmuA:
4.63
3l8lD-5dmuA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8e IGA FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL B  20
VAL B  83
TRP B  36
 None
 0.96A 3l8lC-5e8eB:
undetectable
3l8lD-5e8eB:
undetectable		 3l8lC-5e8eB:
5.39
3l8lD-5e8eB:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 VAL A 285
VAL A 280
TRP A 282
 None
OLA  A1210 ( 4.5A)
None
 0.90A 3l8lC-5ee7A:
undetectable
3l8lD-5ee7A:
undetectable		 3l8lC-5ee7A:
4.11
3l8lD-5ee7A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 VAL A 539
VAL A 548
TRP A 528
 None
 0.92A 3l8lC-5gjeA:
undetectable
3l8lD-5gjeA:
undetectable		 3l8lC-5gjeA:
8.50
3l8lD-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		3 VAL A  39
VAL A 133
TRP A  16
 None
 0.81A 3l8lC-5gqtA:
undetectable
3l8lD-5gqtA:
undetectable		 3l8lC-5gqtA:
2.86
3l8lD-5gqtA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  76
VAL A  78
TRP A 149
 None
 0.81A 3l8lC-5h83A:
undetectable
3l8lD-5h83A:
undetectable		 3l8lC-5h83A:
6.02
3l8lD-5h83A:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		3 VAL B 328
VAL B 323
TRP B 319
 None
 0.90A 3l8lC-5hb4B:
undetectable
3l8lD-5hb4B:
undetectable		 3l8lC-5hb4B:
1.16
3l8lD-5hb4B:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		3 VAL A 142
VAL A 137
TRP A  45
 None
 0.95A 3l8lC-5hyhA:
undetectable
3l8lD-5hyhA:
undetectable		 3l8lC-5hyhA:
4.78
3l8lD-5hyhA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		3 VAL A  92
VAL A  50
TRP A  84
 None
GDP  A 401 (-4.6A)
None
 0.94A 3l8lC-5igpA:
undetectable
3l8lD-5igpA:
undetectable		 3l8lC-5igpA:
5.43
3l8lD-5igpA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN

(Bos taurus) 		no annotation 3 VAL H 136
VAL H  34
TRP H 134
 None
 0.90A 3l8lC-5ijvH:
undetectable
3l8lD-5ijvH:
undetectable		 3l8lC-5ijvH:
5.39
3l8lD-5ijvH:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H 153
VAL H  34
TRP H 151
 None
 0.83A 3l8lC-5iltH:
undetectable
3l8lD-5iltH:
undetectable		 3l8lC-5iltH:
6.45
3l8lD-5iltH:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 VAL D 113
VAL D 193
TRP D 191
 None
 0.85A 3l8lC-5k59D:
undetectable
3l8lD-5k59D:
undetectable		 3l8lC-5k59D:
4.52
3l8lD-5k59D:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kw9 IGA(VH)-IGG(CH)
HEAVY CHAIN FAB
FRAGMENT

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H  20
VAL H  83
TRP H  36
 None
 0.88A 3l8lC-5kw9H:
undetectable
3l8lD-5kw9H:
undetectable		 3l8lC-5kw9H:
5.26
3l8lD-5kw9H:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 133
VAL A 150
TRP A 152
 None
 0.85A 3l8lC-5mdnA:
undetectable
3l8lD-5mdnA:
undetectable		 3l8lC-5mdnA:
1.80
3l8lD-5mdnA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n07 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR NSRR

(Streptomyces
coelicolor) 		PF02082
(Rrf2) 		3 VAL A  75
VAL A  77
TRP A  79
 None
 0.83A 3l8lC-5n07A:
undetectable
3l8lD-5n07A:
undetectable		 3l8lC-5n07A:
8.73
3l8lD-5n07A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		3 VAL A1141
VAL A1139
TRP A1137
 None
 0.95A 3l8lC-5n2sA:
undetectable
3l8lD-5n2sA:
undetectable		 3l8lC-5n2sA:
5.26
3l8lD-5n2sA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1) 		no annotation
no annotation 		3 VAL B 904
VAL A 893
TRP B 906
 None
 0.85A 3l8lC-5nd1B:
undetectable
3l8lD-5nd1B:
undetectable		 3l8lC-5nd1B:
undetectable
3l8lD-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 VAL A1821
VAL A1816
TRP A1758
 None
 0.91A 3l8lC-5nugA:
undetectable
3l8lD-5nugA:
undetectable		 3l8lC-5nugA:
0.74
3l8lD-5nugA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL I 558
VAL I 544
TRP I 546
 None
 0.96A 3l8lC-5o32I:
undetectable
3l8lD-5o32I:
undetectable		 3l8lC-5o32I:
6.44
3l8lD-5o32I:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o64 REACTION CENTER
PROTEIN H CHAIN

(Blastochloris
viridis) 		PF03967
(PRCH)
PF05239
(PRC) 		3 VAL H  28
VAL H  23
TRP H  25
 None
 0.96A 3l8lC-5o64H:
undetectable
3l8lD-5o64H:
undetectable		 3l8lC-5o64H:
6.40
3l8lD-5o64H:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vug UNCHARACTERIZED
PROTEIN RV2277C

(Mycobacterium
tuberculosis) 		PF03009
(GDPD) 		3 VAL A 243
VAL A 265
TRP A 227
 None
 0.92A 3l8lC-5vugA:
undetectable
3l8lD-5vugA:
undetectable		 3l8lC-5vugA:
4.76
3l8lD-5vugA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z

(Pisum sativum) 		PF01737
(Ycf9) 		3 VAL Z  51
VAL Z   9
TRP Z  47
 None
 0.68A 3l8lC-5xnmZ:
undetectable
3l8lD-5xnmZ:
undetectable		 3l8lC-5xnmZ:
20.37
3l8lD-5xnmZ:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 3 VAL A 396
VAL A 406
TRP A 408
 None
 0.91A 3l8lC-6cmzA:
undetectable
3l8lD-6cmzA:
undetectable		 3l8lC-6cmzA:
undetectable
3l8lD-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 VAL B  63
VAL B  61
TRP B  48
 None
 0.81A 3l8lC-6cxhB:
undetectable
3l8lD-6cxhB:
undetectable		 3l8lC-6cxhB:
undetectable
3l8lD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhe -

(-) 		no annotation 3 VAL A  93
VAL A 155
TRP A 167
 None
 0.89A 3l8lC-6fheA:
undetectable
3l8lD-6fheA:
undetectable		 3l8lC-6fheA:
undetectable
3l8lD-6fheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 VAL A 706
VAL A 665
TRP A 702
 None
 0.62A 3l8lC-6fuyA:
undetectable
3l8lD-6fuyA:
undetectable		 3l8lC-6fuyA:
undetectable
3l8lD-6fuyA:
undetectable