SIMILAR PATTERNS OF AMINO ACIDS FOR 3L8L_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00497
(SBP_bac_3) 		3 VAL A  38
VAL A  34
TRP A  35
 None
 0.87A 3l8lA-1iiwA:
undetectable
3l8lB-1iiwA:
undetectable		 3l8lA-1iiwA:
10.26
3l8lB-1iiwA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A  84
VAL A 166
TRP A 164
 None
 0.70A 3l8lA-1lkfA:
undetectable
3l8lB-1lkfA:
undetectable		 3l8lA-1lkfA:
4.28
3l8lB-1lkfA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 VAL A 464
VAL A 466
TRP A 313
 None
 0.78A 3l8lA-1m1cA:
undetectable
3l8lB-1m1cA:
undetectable		 3l8lA-1m1cA:
1.76
3l8lB-1m1cA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdu GELSOLIN PRECURSOR

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL A  45
VAL A  22
TRP A  20
 None
 0.86A 3l8lA-1mduA:
undetectable
3l8lB-1mduA:
undetectable		 3l8lA-1mduA:
7.87
3l8lB-1mduA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8u 6-OXO CAMPHOR
HYDROLASE

(Rhodococcus
erythropolis) 		PF00378
(ECH_1) 		3 VAL A 163
VAL A 158
TRP A 160
 None
 0.91A 3l8lA-1o8uA:
undetectable
3l8lB-1o8uA:
undetectable		 3l8lA-1o8uA:
7.48
3l8lB-1o8uA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 VAL G  69
VAL G  46
TRP G  44
 None
 0.79A 3l8lA-1rgiG:
undetectable
3l8lB-1rgiG:
undetectable		 3l8lA-1rgiG:
3.77
3l8lB-1rgiG:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 VAL A 486
VAL A 506
TRP A 504
 None
 0.88A 3l8lA-1rw9A:
undetectable
3l8lB-1rw9A:
undetectable		 3l8lA-1rw9A:
4.56
3l8lB-1rw9A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF01290
(Thymosin) 		3 VAL G  69
VAL G  46
TRP G  44
 None
 0.81A 3l8lA-1t44G:
undetectable
3l8lB-1t44G:
undetectable		 3l8lA-1t44G:
10.14
3l8lB-1t44G:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 VAL A 102
VAL A 104
TRP A  86
 None
 0.91A 3l8lA-1vftA:
undetectable
3l8lB-1vftA:
undetectable		 3l8lA-1vftA:
11.20
3l8lB-1vftA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 VAL A 464
VAL A 474
TRP A 557
 None
 0.77A 3l8lA-1yr2A:
undetectable
3l8lB-1yr2A:
undetectable		 3l8lA-1yr2A:
4.46
3l8lB-1yr2A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxu AT5G01750 PROTEIN

(Arabidopsis
thaliana) 		PF04525
(LOR) 		3 VAL A 119
VAL A 104
TRP A 102
 None
 0.77A 3l8lA-1zxuA:
undetectable
3l8lB-1zxuA:
undetectable		 3l8lA-1zxuA:
8.00
3l8lB-1zxuA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 VAL B 125
VAL B  38
TRP B 150
 None
 0.72A 3l8lA-2amcB:
undetectable
3l8lB-2amcB:
undetectable		 3l8lA-2amcB:
2.41
3l8lB-2amcB:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cop ACYL-COENZYME A
BINDING DOMAIN
CONTAINING 6

(Homo sapiens) 		PF00887
(ACBP) 		3 VAL A  43
VAL A  41
TRP A  65
 None
 0.68A 3l8lA-2copA:
undetectable
3l8lB-2copA:
undetectable		 3l8lA-2copA:
13.43
3l8lB-2copA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 VAL H  20
VAL H  83
TRP H  36
 None
 0.92A 3l8lA-2d7tH:
undetectable
3l8lB-2d7tH:
undetectable		 3l8lA-2d7tH:
6.52
3l8lB-2d7tH:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 VAL A 124
VAL A 186
TRP A 200
 None
 0.86A 3l8lA-2depA:
undetectable
3l8lB-2depA:
undetectable		 3l8lA-2depA:
9.30
3l8lB-2depA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK

(Mus musculus) 		PF00017
(SH2) 		3 VAL A  36
VAL A  49
TRP A  11
 None
 0.70A 3l8lA-2eu0A:
undetectable
3l8lB-2eu0A:
undetectable		 3l8lA-2eu0A:
4.59
3l8lB-2eu0A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		3 VAL A  88
VAL A 150
TRP A 166
 None
 0.85A 3l8lA-2f8qA:
undetectable
3l8lB-2f8qA:
undetectable		 3l8lA-2f8qA:
3.78
3l8lB-2f8qA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fca TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Bacillus
subtilis) 		PF02390
(Methyltransf_4) 		3 VAL A 103
VAL A 142
TRP A  31
 None
 0.92A 3l8lA-2fcaA:
undetectable
3l8lB-2fcaA:
undetectable		 3l8lA-2fcaA:
7.74
3l8lB-2fcaA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff6 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  69
VAL G  46
TRP G  44
 None
 0.85A 3l8lA-2ff6G:
undetectable
3l8lB-2ff6G:
undetectable		 3l8lA-2ff6G:
10.11
3l8lB-2ff6G:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02589
(LUD_dom) 		3 VAL A 167
VAL A 174
TRP A 182
 None
 0.91A 3l8lA-2g40A:
undetectable
3l8lB-2g40A:
undetectable		 3l8lA-2g40A:
9.57
3l8lB-2g40A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		3 VAL A1698
VAL A1965
TRP A1963
 None
 0.82A 3l8lA-2ix8A:
undetectable
3l8lB-2ix8A:
undetectable		 3l8lA-2ix8A:
2.19
3l8lB-2ix8A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		3 VAL A 385
VAL A 383
TRP A 395
 None
 0.85A 3l8lA-2janA:
undetectable
3l8lB-2janA:
undetectable		 3l8lA-2janA:
5.45
3l8lB-2janA:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2

(Homo sapiens) 		PF08210
(APOBEC_N) 		3 VAL A 192
VAL A 187
TRP A 188
 None
 0.82A 3l8lA-2nytA:
undetectable
3l8lB-2nytA:
undetectable		 3l8lA-2nytA:
6.90
3l8lB-2nytA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		3 VAL A 187
VAL A 224
TRP A 222
 None
 0.68A 3l8lA-2o0xA:
undetectable
3l8lB-2o0xA:
undetectable		 3l8lA-2o0xA:
3.19
3l8lB-2o0xA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A 357
VAL A 355
TRP A  47
 None
 0.88A 3l8lA-2oqhA:
undetectable
3l8lB-2oqhA:
undetectable		 3l8lA-2oqhA:
4.10
3l8lB-2oqhA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SAH  A 301 (-3.8A)
None
None
 0.76A 3l8lA-2oy0A:
undetectable
3l8lB-2oy0A:
undetectable		 3l8lA-2oy0A:
6.78
3l8lB-2oy0A:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		3 VAL A  76
VAL A  82
TRP A 123
 None
 0.91A 3l8lA-2q17A:
undetectable
3l8lB-2q17A:
undetectable		 3l8lA-2q17A:
5.11
3l8lB-2q17A:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		3 VAL A  98
VAL A 160
TRP A 172
 None
 0.84A 3l8lA-2uwfA:
undetectable
3l8lB-2uwfA:
undetectable		 3l8lA-2uwfA:
3.53
3l8lB-2uwfA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p AQUAPORIN PIP2-7
7


(Komagataella
pastoris) 		PF00230
(MIP) 		3 VAL A 191
VAL A 186
TRP A 260
 None
 0.90A 3l8lA-2w1pA:
undetectable
3l8lB-2w1pA:
undetectable		 3l8lA-2w1pA:
5.70
3l8lB-2w1pA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		3 VAL A 249
VAL A 245
TRP A  97
 None
 0.90A 3l8lA-2z3tA:
undetectable
3l8lB-2z3tA:
undetectable		 3l8lA-2z3tA:
3.87
3l8lB-2z3tA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c PROTEIN YPL144W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		3 VAL A  42
VAL A 114
TRP A 116
 None
 0.76A 3l8lA-2z5cA:
undetectable
3l8lB-2z5cA:
undetectable		 3l8lA-2z5cA:
7.94
3l8lB-2z5cA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3att PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01636
(APH) 		3 VAL A 113
VAL A 116
TRP A 268
 None
 0.86A 3l8lA-3attA:
undetectable
3l8lB-3attA:
undetectable		 3l8lA-3attA:
9.03
3l8lB-3attA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbt PHOSPHATASE SC4828

(Streptomyces
coelicolor) 		PF04167
(DUF402) 		3 VAL A 156
VAL A 132
TRP A 130
 VAL  A 156 ( 0.6A)
VAL  A 132 ( 0.6A)
TRP  A 130 (-0.5A)
 0.72A 3l8lA-3cbtA:
undetectable
3l8lB-3cbtA:
undetectable		 3l8lA-3cbtA:
7.55
3l8lB-3cbtA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 VAL A 699
VAL A 742
TRP A 713
 None
 0.76A 3l8lA-3dmkA:
undetectable
3l8lB-3dmkA:
undetectable		 3l8lA-3dmkA:
2.09
3l8lB-3dmkA:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		3 VAL A 305
VAL A 308
TRP A 295
 None
 0.84A 3l8lA-3e7gA:
undetectable
3l8lB-3e7gA:
undetectable		 3l8lA-3e7gA:
2.91
3l8lB-3e7gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Brucella suis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		3 VAL A  47
VAL A  49
TRP A  63
 None
 0.82A 3l8lA-3eg4A:
undetectable
3l8lB-3eg4A:
undetectable		 3l8lA-3eg4A:
3.29
3l8lB-3eg4A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f65 CHAPERONE PROTEIN
FAEE

(Escherichia
coli) 		PF00345
(PapD_N) 		3 VAL A  82
VAL A  41
TRP A  84
 None
 0.87A 3l8lA-3f65A:
undetectable
3l8lB-3f65A:
undetectable		 3l8lA-3f65A:
4.93
3l8lB-3f65A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 VAL A3464
VAL A3488
TRP A3514
 None
 0.86A 3l8lA-3fzyA:
undetectable
3l8lB-3fzyA:
undetectable		 3l8lA-3fzyA:
6.33
3l8lB-3fzyA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcd RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 VAL A  36
VAL A  60
TRP A  86
 None
 0.82A 3l8lA-3gcdA:
undetectable
3l8lB-3gcdA:
undetectable		 3l8lA-3gcdA:
7.93
3l8lB-3gcdA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SAM  A4633 (-3.6A)
None
None
 0.84A 3l8lA-3gczA:
undetectable
3l8lB-3gczA:
undetectable		 3l8lA-3gczA:
6.09
3l8lB-3gczA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		3 VAL A  41
VAL A 234
TRP A  43
 None
 0.73A 3l8lA-3irvA:
undetectable
3l8lB-3irvA:
undetectable		 3l8lA-3irvA:
9.78
3l8lB-3irvA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 VAL A 266
VAL A 262
TRP A 130
 None
 0.83A 3l8lA-3jxfA:
undetectable
3l8lB-3jxfA:
undetectable		 3l8lA-3jxfA:
4.61
3l8lB-3jxfA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkj CD40 LIGAND

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 239
VAL A 237
TRP A 140
 None
 0.45A 3l8lA-3lkjA:
undetectable
3l8lB-3lkjA:
undetectable		 3l8lA-3lkjA:
4.96
3l8lB-3lkjA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SFG  A 301 (-4.1A)
None
None
 0.72A 3l8lA-3lkzA:
undetectable
3l8lB-3lkzA:
undetectable		 3l8lA-3lkzA:
4.30
3l8lB-3lkzA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4e ALPHA-HEMOLYSIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A  86
VAL A 169
TRP A 167
 None
 0.81A 3l8lA-3m4eA:
undetectable
3l8lB-3m4eA:
undetectable		 3l8lA-3m4eA:
4.10
3l8lB-3m4eA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 VAL A  52
VAL A  50
TRP A  80
 None
 0.88A 3l8lA-3mgaA:
undetectable
3l8lB-3mgaA:
undetectable		 3l8lA-3mgaA:
3.23
3l8lB-3mgaA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 VAL A 256
VAL A 251
TRP A 253
 None
 0.89A 3l8lA-3mjfA:
undetectable
3l8lB-3mjfA:
undetectable		 3l8lA-3mjfA:
3.80
3l8lB-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		3 VAL C 248
VAL C 246
TRP C  82
 None
 0.83A 3l8lA-3napC:
undetectable
3l8lB-3napC:
undetectable		 3l8lA-3napC:
5.85
3l8lB-3napC:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 VAL A 342
VAL A 352
TRP A 143
 None
 0.84A 3l8lA-3nlcA:
undetectable
3l8lB-3nlcA:
undetectable		 3l8lA-3nlcA:
2.41
3l8lB-3nlcA:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A 351
VAL A 349
TRP A  28
 None
 0.64A 3l8lA-3t8qA:
undetectable
3l8lB-3t8qA:
undetectable		 3l8lA-3t8qA:
8.14
3l8lB-3t8qA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128) 		PF10604
(Polyketide_cyc2) 		3 VAL A  53
VAL A  37
TRP A  62
 None
None
CXS  A 171 (-4.4A)
 0.76A 3l8lA-3tfzA:
undetectable
3l8lB-3tfzA:
undetectable		 3l8lA-3tfzA:
11.00
3l8lB-3tfzA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin) 		3 VAL B  45
VAL B  22
TRP B  20
 None
 0.84A 3l8lA-3tu5B:
undetectable
3l8lB-3tu5B:
undetectable		 3l8lA-3tu5B:
4.65
3l8lB-3tu5B:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 VAL B 745
VAL B 588
TRP B 591
 None
 0.90A 3l8lA-3v0aB:
undetectable
3l8lB-3v0aB:
undetectable		 3l8lA-3v0aB:
1.19
3l8lB-3v0aB:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		3 VAL A 158
VAL A 154
TRP A 155
 None
 0.91A 3l8lA-3vasA:
undetectable
3l8lB-3vasA:
undetectable		 3l8lA-3vasA:
15.49
3l8lB-3vasA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waz PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
abyssi) 		PF09522
(RE_R_Pab1) 		3 VAL A 166
VAL A 164
TRP A  64
 None
ADE  A 301 (-3.8A)
None
 0.79A 3l8lA-3wazA:
undetectable
3l8lB-3wazA:
undetectable		 3l8lA-3wazA:
5.35
3l8lB-3wazA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D

(Phanerochaete
chrysosporium) 		PF03443
(Glyco_hydro_61) 		3 VAL A  21
VAL A  19
TRP A  18
 None
 0.87A 3l8lA-4b5qA:
undetectable
3l8lB-4b5qA:
undetectable		 3l8lA-4b5qA:
5.26
3l8lB-4b5qA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		3 VAL A 601
VAL A 606
TRP A 585
 None
 0.81A 3l8lA-4bq4A:
undetectable
3l8lB-4bq4A:
undetectable		 3l8lA-4bq4A:
3.61
3l8lB-4bq4A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A  54
VAL A  60
TRP A  58
 None
 0.83A 3l8lA-4btmA:
undetectable
3l8lB-4btmA:
undetectable		 3l8lA-4btmA:
4.00
3l8lB-4btmA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		3 VAL A  20
VAL A  96
TRP A 105
 None
 0.81A 3l8lA-4d7pA:
undetectable
3l8lB-4d7pA:
undetectable		 3l8lA-4d7pA:
8.05
3l8lB-4d7pA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		3 VAL A1050
VAL A1048
TRP A1157
 None
 0.90A 3l8lA-4f1nA:
undetectable
3l8lB-4f1nA:
undetectable		 3l8lA-4f1nA:
1.43
3l8lB-4f1nA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		3 VAL A 339
VAL A 361
TRP A 334
 None
 0.91A 3l8lA-4ftdA:
undetectable
3l8lB-4ftdA:
undetectable		 3l8lA-4ftdA:
2.43
3l8lB-4ftdA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu FAB 8M2 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H  20
VAL H  82
TRP H  36
 None
 0.92A 3l8lA-4hfuH:
undetectable
3l8lB-4hfuH:
undetectable		 3l8lA-4hfuH:
8.85
3l8lB-4hfuH:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igv KIROLA

(Actinidia
deliciosa) 		PF00407
(Bet_v_1) 		3 VAL A 103
VAL A 105
TRP A 116
 None
 0.69A 3l8lA-4igvA:
undetectable
3l8lB-4igvA:
undetectable		 3l8lA-4igvA:
8.08
3l8lB-4igvA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		3 VAL A  51
VAL A  49
TRP A  14
 None
 0.74A 3l8lA-4jcsA:
undetectable
3l8lB-4jcsA:
undetectable		 3l8lA-4jcsA:
6.92
3l8lB-4jcsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		3 VAL A  15
VAL A 167
TRP A 168
 None
 0.84A 3l8lA-4jo5A:
undetectable
3l8lB-4jo5A:
undetectable		 3l8lA-4jo5A:
5.33
3l8lB-4jo5A:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 217
VAL A 215
TRP A 114
 None
 0.76A 3l8lA-4kg8A:
undetectable
3l8lB-4kg8A:
undetectable		 3l8lA-4kg8A:
11.21
3l8lB-4kg8A:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		3 VAL A 305
VAL A 314
TRP A 202
 None
HEM  A 400 ( 4.9A)
None
 0.61A 3l8lA-4mf9A:
undetectable
3l8lB-4mf9A:
undetectable		 3l8lA-4mf9A:
4.30
3l8lB-4mf9A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A  30
VAL A  36
TRP A  34
 None
 0.81A 3l8lA-4nfnA:
undetectable
3l8lB-4nfnA:
undetectable		 3l8lA-4nfnA:
4.45
3l8lB-4nfnA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51

(Mus musculus) 		PF03281
(Mab-21) 		3 VAL A 262
VAL A 252
TRP A 337
 None
 0.82A 3l8lA-4oahA:
undetectable
3l8lB-4oahA:
undetectable		 3l8lA-4oahA:
3.75
3l8lB-4oahA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ole NEXT TO BRCA1 GENE 1
PROTEIN

(Homo sapiens) 		PF16158
(N_BRCA1_IG) 		3 VAL A 429
VAL A 442
TRP A 459
 None
 0.86A 3l8lA-4oleA:
undetectable
3l8lB-4oleA:
undetectable		 3l8lA-4oleA:
9.26
3l8lB-4oleA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin)
PF03250
(Tropomodulin) 		3 VAL B  96
VAL B  73
TRP B  71
 None
 0.77A 3l8lA-4pkhB:
undetectable
3l8lB-4pkhB:
undetectable		 3l8lA-4pkhB:
4.42
3l8lB-4pkhB:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  96
VAL G  73
TRP G  71
 None
 0.83A 3l8lA-4pkiG:
undetectable
3l8lB-4pkiG:
undetectable		 3l8lA-4pkiG:
8.47
3l8lB-4pkiG:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 VAL A  98
VAL A 160
TRP A 172
 None
 0.85A 3l8lA-4pueA:
undetectable
3l8lB-4pueA:
undetectable		 3l8lA-4pueA:
3.28
3l8lB-4pueA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7g LEUCOTOXIN LUKDV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 VAL A 110
VAL A 192
TRP A 190
 None
 0.68A 3l8lA-4q7gA:
undetectable
3l8lB-4q7gA:
undetectable		 3l8lA-4q7gA:
5.09
3l8lB-4q7gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 232
VAL A 230
TRP A 208
 None
None
NAP  A 501 ( 4.8A)
 0.90A 3l8lA-4y1bA:
undetectable
3l8lB-4y1bA:
undetectable		 3l8lA-4y1bA:
4.78
3l8lB-4y1bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		3 VAL G  45
VAL G  22
TRP G  20
 None
 0.86A 3l8lA-4z94G:
undetectable
3l8lB-4z94G:
undetectable		 3l8lA-4z94G:
4.68
3l8lB-4z94G:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		3 VAL A 400
VAL A 456
TRP A 359
 None
 0.88A 3l8lA-4zaaA:
undetectable
3l8lB-4zaaA:
undetectable		 3l8lA-4zaaA:
6.63
3l8lB-4zaaA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b82 TLL0287 PROTEIN

(Thermosynechococcus
elongatus) 		PF11845
(DUF3365) 		3 VAL A 178
VAL A 129
TRP A  84
 None
 0.83A 3l8lA-5b82A:
undetectable
3l8lB-5b82A:
undetectable		 3l8lA-5b82A:
6.61
3l8lB-5b82A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		3 VAL A 511
VAL A  32
TRP A 500
 None
 0.92A 3l8lA-5bp8A:
undetectable
3l8lB-5bp8A:
undetectable		 3l8lA-5bp8A:
2.94
3l8lB-5bp8A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cze PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL B  81
VAL B  79
TRP B   6
 None
 0.80A 3l8lA-5czeB:
undetectable
3l8lB-5czeB:
undetectable		 3l8lA-5czeB:
17.95
3l8lB-5czeB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		3 VAL C  81
VAL C  79
TRP C   6
 None
 0.84A 3l8lA-5czfC:
undetectable
3l8lB-5czfC:
undetectable		 3l8lA-5czfC:
14.29
3l8lB-5czfC:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 3 VAL A 194
VAL A 196
TRP A 272
 None
 0.80A 3l8lA-5dmuA:
undetectable
3l8lB-5dmuA:
undetectable		 3l8lA-5dmuA:
4.63
3l8lB-5dmuA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8e IGA FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL B  20
VAL B  83
TRP B  36
 None
 0.89A 3l8lA-5e8eB:
undetectable
3l8lB-5e8eB:
undetectable		 3l8lA-5e8eB:
5.39
3l8lB-5e8eB:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 VAL A 539
VAL A 548
TRP A 528
 None
 0.87A 3l8lA-5gjeA:
undetectable
3l8lB-5gjeA:
undetectable		 3l8lA-5gjeA:
8.50
3l8lB-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		3 VAL A  92
VAL A  50
TRP A  84
 None
GDP  A 401 (-4.6A)
None
 0.86A 3l8lA-5igpA:
undetectable
3l8lB-5igpA:
undetectable		 3l8lA-5igpA:
5.43
3l8lB-5igpA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 VAL A 132
VAL A 164
TRP A 171
 SAH  A1003 (-3.7A)
None
None
 0.87A 3l8lA-5jjrA:
undetectable
3l8lB-5jjrA:
undetectable		 3l8lA-5jjrA:
2.83
3l8lB-5jjrA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1

(Staphylococcus
aureus) 		no annotation 3 VAL B  86
VAL B 170
TRP B 168
 None
 0.77A 3l8lA-5k59B:
undetectable
3l8lB-5k59B:
undetectable		 3l8lA-5k59B:
8.59
3l8lB-5k59B:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 VAL D 113
VAL D 193
TRP D 191
 None
 0.58A 3l8lA-5k59D:
undetectable
3l8lB-5k59D:
undetectable		 3l8lA-5k59D:
4.52
3l8lB-5k59D:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kw9 IGA(VH)-IGG(CH)
HEAVY CHAIN FAB
FRAGMENT

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 VAL H  20
VAL H  83
TRP H  36
 None
 0.77A 3l8lA-5kw9H:
undetectable
3l8lB-5kw9H:
undetectable		 3l8lA-5kw9H:
5.26
3l8lB-5kw9H:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		3 VAL A 346
VAL A 342
TRP A 343
 None
 0.88A 3l8lA-5kx6A:
undetectable
3l8lB-5kx6A:
undetectable		 3l8lA-5kx6A:
6.22
3l8lB-5kx6A:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		3 VAL A  70
VAL A  76
TRP A 117
 None
 0.90A 3l8lA-5nyyA:
undetectable
3l8lB-5nyyA:
undetectable		 3l8lA-5nyyA:
5.42
3l8lB-5nyyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o64 REACTION CENTER
PROTEIN H CHAIN

(Blastochloris
viridis) 		PF03967
(PRCH)
PF05239
(PRC) 		3 VAL H  28
VAL H  23
TRP H  25
 None
 0.91A 3l8lA-5o64H:
undetectable
3l8lB-5o64H:
undetectable		 3l8lA-5o64H:
6.40
3l8lB-5o64H:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 3 VAL A 567
VAL A 571
TRP A 596
 None
 0.92A 3l8lA-5uc1A:
undetectable
3l8lB-5uc1A:
undetectable		 3l8lA-5uc1A:
undetectable
3l8lB-5uc1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE
METHANOL
DEHYDROGENASE
[CYTOCHROME C]
SUBUNIT 2

(Methylophaga
aminisulfidivorans;
Methylophaga
aminisulfidivorans) 		no annotation
no annotation 		3 VAL A 178
VAL B  79
TRP A 176
 None
 0.77A 3l8lA-5xm3A:
undetectable
3l8lB-5xm3A:
undetectable		 3l8lA-5xm3A:
undetectable
3l8lB-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 VAL C  55
VAL C  51
TRP C  15
 None
 0.77A 3l8lA-5xynC:
undetectable
3l8lB-5xynC:
undetectable		 3l8lA-5xynC:
9.76
3l8lB-5xynC:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 3 VAL B 307
VAL B 321
TRP B 335
 None
 0.90A 3l8lA-5yx2B:
undetectable
3l8lB-5yx2B:
undetectable		 3l8lA-5yx2B:
undetectable
3l8lB-5yx2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 3 VAL A 238
VAL A 253
TRP A 225
 None
 0.82A 3l8lA-6em0A:
undetectable
3l8lB-6em0A:
undetectable		 3l8lA-6em0A:
undetectable
3l8lB-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 VAL A 781
VAL A 811
TRP A 784
 None
 0.89A 3l8lA-6eotA:
undetectable
3l8lB-6eotA:
undetectable		 3l8lA-6eotA:
undetectable
3l8lB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 3 VAL A  98
VAL A 160
TRP A 174
 None
 0.80A 3l8lA-6fhfA:
undetectable
3l8lB-6fhfA:
undetectable		 3l8lA-6fhfA:
undetectable
3l8lB-6fhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 VAL A 706
VAL A 665
TRP A 702
 None
 0.86A 3l8lA-6fuyA:
undetectable
3l8lB-6fuyA:
undetectable		 3l8lA-6fuyA:
undetectable
3l8lB-6fuyA:
undetectable