SIMILAR PATTERNS OF AMINO ACIDS FOR 3L8L_A_DVAA8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxd GA REPEAT BINDING
PROTEIN, ALPHA

(Mus musculus) 		PF02198
(SAM_PNT) 		4 VAL A 198
TRP A 189
VAL A 194
TRP A 241
 None
 1.34A 3l8lA-1sxdA:
undetectable
3l8lB-1sxdA:
undetectable		 3l8lA-1sxdA:
11.76
3l8lB-1sxdA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		4 VAL A 265
TRP A 262
VAL A 263
TRP A 266
 None
GOL  A 276 (-4.1A)
None
PEG  A 268 (-3.8A)
 1.46A 3l8lA-3rq0A:
undetectable
3l8lB-3rq0A:
undetectable		 3l8lA-3rq0A:
5.00
3l8lB-3rq0A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq9 BETA-1,3-GLUCANASE

(Mycobacterium
marinum) 		PF00722
(Glyco_hydro_16) 		4 VAL A 257
TRP A 254
VAL A 255
TRP A 258
 None
 1.44A 3l8lA-4pq9A:
undetectable
3l8lB-4pq9A:
undetectable		 3l8lA-4pq9A:
4.76
3l8lB-4pq9A:
4.76