SIMILAR PATTERNS OF AMINO ACIDS FOR 3L7K_A_EDTA739

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0k HYPOTHETICAL PROTEIN
PA4535

(Pseudomonas
aeruginosa) 		PF08682
(DUF1780) 		4 LEU A   7
ARG A   8
ARG A 149
LYS A 105
 None
 1.33A 3l7kA-1y0kA:
0.0
3l7kB-1y0kA:
0.0		 3l7kA-1y0kA:
14.92
3l7kB-1y0kA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 LEU A 240
ARG A 267
ARG A 275
LYS A 274
 None
 1.30A 3l7kA-3gl1A:
0.0
3l7kB-3gl1A:
0.0		 3l7kA-3gl1A:
20.66
3l7kB-3gl1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		4 LEU A  28
LYS A  25
ARG A  33
LYS A  32
 None
 1.46A 3l7kA-3kydA:
4.8
3l7kB-3kydA:
5.0		 3l7kA-3kydA:
18.04
3l7kB-3kydA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t61 GLUCONOKINASE

(Sinorhizobium
meliloti) 		PF01202
(SKI) 		4 LEU A 175
ARG A 177
ARG A  13
LYS A  13
 None
 1.46A 3l7kA-3t61A:
2.5
3l7kB-3t61A:
2.5		 3l7kA-3t61A:
12.89
3l7kB-3t61A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13481
(AAA_25)
PF13541
(ChlI) 		4 LEU A  81
ARG A  69
LYS A  71
ARG A  79
 None
 1.12A 3l7kA-5lkmA:
1.7
3l7kB-5lkmA:
0.7		 3l7kA-5lkmA:
20.64
3l7kB-5lkmA:
20.64