SIMILAR PATTERNS OF AMINO ACIDS FOR 3L4D_A_TPFA490_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		4 PHE A 362
ALA A 296
ALA A 268
THR A 272
 None
 0.88A 3l4dA-1a0cA:
undetectable		 3l4dA-1a0cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		4 PHE A 360
ALA A 294
ALA A 266
THR A 270
 None
 0.92A 3l4dA-1a0dA:
undetectable		 3l4dA-1a0dA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		4 PHE A 362
ALA A 296
ALA A 268
THR A 272
 None
 0.88A 3l4dA-1a0eA:
undetectable		 3l4dA-1a0eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 PHE A 424
ALA A 402
ALA A 404
THR A 406
 None
 0.98A 3l4dA-1dlcA:
undetectable		 3l4dA-1dlcA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 PHE A  94
ALA A 155
THR A 182
LEU A  85
 None
 0.96A 3l4dA-1dppA:
undetectable		 3l4dA-1dppA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 ALA B 881
ALA B 885
THR B 807
LEU B 549
 None
 0.94A 3l4dA-1ej6B:
undetectable		 3l4dA-1ej6B:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggv DIENELACTONE
HYDROLASE

(Pseudomonas
putida) 		PF01738
(DLH) 		4 ALA A 216
ALA A 220
THR A 224
LEU A 164
 None
 0.82A 3l4dA-1ggvA:
undetectable		 3l4dA-1ggvA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 PHE A 100
ALA A  78
THR A  14
LEU A  27
 None
 0.92A 3l4dA-1hl2A:
undetectable		 3l4dA-1hl2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 TYR A   8
ALA A 609
THR A 637
LEU A 663
 None
 0.96A 3l4dA-1j1wA:
undetectable		 3l4dA-1j1wA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwq N-ACETYLMURAMOYL-L-A
LANINE AMIDASE CWLV

(Paenibacillus
polymyxa) 		PF01520
(Amidase_3) 		4 ALA A 165
ALA A 169
THR A 173
LEU A  47
 None
 0.84A 3l4dA-1jwqA:
undetectable		 3l4dA-1jwqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Agrobacterium
tumefaciens) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 PHE A 101
ALA A 105
THR A  51
LEU A  40
 LAE  A1003 (-4.2A)
LAE  A1003 (-3.2A)
LAE  A1003 ( 4.2A)
LAE  A1003 (-4.0A)
 0.95A 3l4dA-1l3lA:
undetectable		 3l4dA-1l3lA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		5 PHE B 338
TYR B 227
ALA B 263
THR B 280
LEU B 148
 None
 1.16A 3l4dA-1mhyB:
undetectable		 3l4dA-1mhyB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 PHE A 655
ALA A 811
ALA A 815
THR A 819
 None
 0.83A 3l4dA-1n5xA:
undetectable		 3l4dA-1n5xA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nio B-LUFFIN

(Luffa
aegyptiaca) 		PF00161
(RIP) 		4 TYR A  82
TYR A  75
ALA A 150
ALA A 146
 None
 0.91A 3l4dA-1nioA:
undetectable		 3l4dA-1nioA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 114
ALA A 294
THR A 298
LEU A 359
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
DIF  A 501 (-4.4A)
 0.78A 3l4dA-1nr6A:
33.3		 3l4dA-1nr6A:
27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C) 		4 TYR D 775
ALA A 161
THR D 795
LEU D 811
 None
 0.97A 3l4dA-1o7dD:
undetectable		 3l4dA-1o7dD:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qju PROTEIN VP1

(Rhinovirus A) 		PF00073
(Rhv) 		4 PHE 1 118
ALA 1 116
THR 1 208
MET 1 214
 None
None
None
W01  17001 (-4.1A)
 0.71A 3l4dA-1qju1:
undetectable		 3l4dA-1qju1:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4o GLYCOLIPID
2-ALPHA-MANNOSYLTRAN
SFERASE

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		4 TYR A 319
ALA A 370
ALA A 368
LEU A 348
 None
 0.96A 3l4dA-1s4oA:
undetectable		 3l4dA-1s4oA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soi MUTT/NUDIX FAMILY
PROTEIN

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		4 ALA A  62
ALA A  66
THR A  70
LEU A  28
 None
 0.86A 3l4dA-1soiA:
undetectable		 3l4dA-1soiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 ALA C 240
ALA C 244
THR C 248
LEU C 213
 None
 0.55A 3l4dA-1t3qC:
undetectable		 3l4dA-1t3qC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh) 		4 TYR A 170
ALA A 151
ALA A 167
LEU A  92
 None
 0.91A 3l4dA-1w85A:
undetectable		 3l4dA-1w85A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 269
ALA A 327
ALA A 331
LEU B  42
 None
 0.96A 3l4dA-1wytA:
undetectable		 3l4dA-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 PHE A 106
ALA A  98
ALA A  94
MET A  87
 None
 0.85A 3l4dA-1x77A:
undetectable		 3l4dA-1x77A:
15.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 TYR A  76
ALA A 256
THR A 260
LEU A 321
 ESL  A 471 ( 3.8A)
ESL  A 471 ( 3.4A)
HEM  A 470 (-3.6A)
HEM  A 470 (-4.1A)
 0.75A 3l4dA-1x8vA:
38.6		 3l4dA-1x8vA:
32.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x94 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Vibrio cholerae) 		PF13580
(SIS_2) 		4 TYR A 104
ALA A  59
ALA A  63
THR A  67
 None
 0.82A 3l4dA-1x94A:
undetectable		 3l4dA-1x94A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES

(Homo sapiens) 		PF13883
(Pyrid_oxidase_2) 		4 ALA A  19
ALA A  23
THR A  27
LEU A 116
 None
 0.98A 3l4dA-1xhnA:
undetectable		 3l4dA-1xhnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo2 NUCLEAR TRANSPORT
FACTOR 2

(Cryptosporidium
parvum) 		PF02136
(NTF2) 		4 TYR A  21
PHE A  69
TYR A  22
LEU A  42
 None
 0.89A 3l4dA-1zo2A:
undetectable		 3l4dA-1zo2A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis) 		PF01182
(Glucosamine_iso) 		4 TYR A   9
ALA A  17
THR A  20
LEU A 130
 None
 0.91A 3l4dA-2bkxA:
undetectable		 3l4dA-2bkxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 ALA A 268
ALA A 272
THR A 276
LEU A  28
 None
 0.95A 3l4dA-2cfoA:
undetectable		 3l4dA-2cfoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A  32
TYR A  82
ALA A  42
LEU A  17
 None
 0.94A 3l4dA-2cxeA:
undetectable		 3l4dA-2cxeA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 PHE A 269
TYR A 262
ALA A 363
THR A 368
 None
 0.93A 3l4dA-2e9fA:
undetectable		 3l4dA-2e9fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		4 TYR A  58
ALA A  80
ALA A  83
LEU A  16
 None
 0.92A 3l4dA-2fefA:
undetectable		 3l4dA-2fefA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		5 PHE A 167
TYR A 171
ALA A 154
ALA A 152
LEU A 185
 None
 1.14A 3l4dA-2hcbA:
undetectable		 3l4dA-2hcbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		4 TYR A 247
ALA A 257
ALA A 261
THR A 265
 None
 0.92A 3l4dA-2hj0A:
undetectable		 3l4dA-2hj0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2w PHOSPHOHEPTOSE
ISOMERASE

(Escherichia
coli) 		PF13580
(SIS_2) 		4 TYR A 104
ALA A  59
ALA A  63
THR A  67
 None
 0.70A 3l4dA-2i2wA:
undetectable		 3l4dA-2i2wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knq GENERAL SECRETION
PATHWAY PROTEIN H

(Escherichia
coli) 		PF12019
(GspH) 		4 ALA A  13
ALA A  17
THR A  21
LEU A 132
 None
 0.97A 3l4dA-2knqA:
undetectable		 3l4dA-2knqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcq PUTATIVE TOXIN VAPC6

(Pyrococcus
horikoshii) 		PF17146
(PIN_6) 		4 TYR A  90
ALA A  69
THR A  72
LEU A 109
 None
 0.93A 3l4dA-2lcqA:
undetectable		 3l4dA-2lcqA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00977
(His_biosynth) 		4 PHE A 206
ALA A 202
ALA A 200
LEU A 220
 None
 0.98A 3l4dA-2lleA:
undetectable		 3l4dA-2lleA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5t HUMAN RHINOVIRUS 2A
PROTEINASE

(Rhinovirus C) 		PF00947
(Pico_P2A) 		4 ALA A  30
ALA A  33
THR A 120
LEU A  93
 None
 0.83A 3l4dA-2m5tA:
undetectable		 3l4dA-2m5tA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans) 		PF01070
(FMN_dh) 		4 PHE A 193
TYR A   8
ALA A  96
THR A 108
 None
 0.96A 3l4dA-2nliA:
undetectable		 3l4dA-2nliA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		4 TYR A  81
TYR A  74
ALA A 149
ALA A 145
 None
 0.92A 3l4dA-2oqaA:
undetectable		 3l4dA-2oqaA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		4 ALA A 164
ALA A 168
THR A 172
LEU A  89
 None
 0.90A 3l4dA-2pthA:
undetectable		 3l4dA-2pthA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 ALA A 571
ALA A 575
THR A 579
LEU A 547
 None
 0.84A 3l4dA-2pziA:
undetectable		 3l4dA-2pziA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 ALA A 215
ALA A 219
THR A 223
LEU A  24
 None
 0.89A 3l4dA-2uvdA:
undetectable		 3l4dA-2uvdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 TYR F 618
ALA F 488
ALA F 491
MET F 535
 None
 0.96A 3l4dA-2v2fF:
undetectable		 3l4dA-2v2fF:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p
AQUAPORIN PIP2-7 7

(Komagataella
pastoris) 		PF00230
(MIP) 		4 PHE A  56
ALA A 144
ALA A 148
THR A 152
 None
 0.74A 3l4dA-2w1pA:
undetectable		 3l4dA-2w1pA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymv ACG NITROREDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ALA A  19
ALA A  15
THR A  11
LEU A   7
 None
 0.98A 3l4dA-2ymvA:
undetectable		 3l4dA-2ymvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 PHE A  84
ALA A  86
ALA A  90
LEU A 326
 None
 0.74A 3l4dA-2zpaA:
undetectable		 3l4dA-2zpaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 TYR B  36
ALA B 223
ALA B 227
THR B 231
 None
 0.77A 3l4dA-3amjB:
undetectable		 3l4dA-3amjB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus) 		PF01351
(RNase_HII)
PF11858
(DUF3378) 		5 PHE A 105
TYR A 104
ALA A 275
ALA A 277
LEU A 303
 None
 1.42A 3l4dA-3asmA:
undetectable		 3l4dA-3asmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		4 TYR A  81
TYR A  74
ALA A 148
ALA A 144
 None
 0.90A 3l4dA-3bwhA:
undetectable		 3l4dA-3bwhA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjy PUTATIVE
THIOESTERASE

(Novosphingobium
aromaticivorans) 		PF13622
(4HBT_3) 		4 PHE A  35
ALA A  38
ALA A 181
LEU A 239
 None
 0.97A 3l4dA-3cjyA:
undetectable		 3l4dA-3cjyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PHE A1179
ALA A1158
LEU A1227
MET A1196
 None
 0.82A 3l4dA-3eh1A:
undetectable		 3l4dA-3eh1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		4 ALA A 233
ALA A 237
THR A 241
LEU A 313
 None
 0.78A 3l4dA-3godA:
undetectable		 3l4dA-3godA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		4 PHE A 110
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.37A 3l4dA-3kswA:
44.7		 3l4dA-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		4 TYR A 103
THR A 295
LEU A 356
MET A 460
 None
VNF  A 490 ( 4.0A)
None
None
 0.74A 3l4dA-3kswA:
44.7		 3l4dA-3kswA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		5 TYR A 103
TYR A 116
ALA A 287
ALA A 291
THR A 295
 None
VNF  A 490 (-4.6A)
VNF  A 490 ( 3.9A)
VNF  A 490 ( 4.0A)
VNF  A 490 ( 4.0A)
 0.92A 3l4dA-3kswA:
44.7		 3l4dA-3kswA:
76.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4a PUTATIVE TYPE I
TOPOISOMERASE

(Deinococcus
radiodurans) 		PF01028
(Topoisom_I) 		5 PHE A 136
ALA A 134
ALA A 182
THR A 166
MET A 192
 None
 1.40A 3l4dA-3m4aA:
undetectable		 3l4dA-3m4aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 4 TYR G 411
ALA G  30
ALA G  34
LEU G  71
 None
 0.98A 3l4dA-3mmpG:
undetectable		 3l4dA-3mmpG:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		4 ALA A 396
ALA A 400
THR A 404
LEU A 353
 None
 0.94A 3l4dA-3nd0A:
undetectable		 3l4dA-3nd0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqk UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		5 PHE A 293
TYR A 295
ALA A 186
THR A 206
LEU A 225
 None
 1.50A 3l4dA-3nqkA:
undetectable		 3l4dA-3nqkA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 TYR B 101
ALA B  44
ALA B  41
LEU B  29
 NAG  B 340 (-4.0A)
None
None
None
 0.98A 3l4dA-3o4oB:
undetectable		 3l4dA-3o4oB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 PHE A  89
ALA A 243
THR A 247
LEU A 290
 None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-4.5A)
 0.71A 3l4dA-3p3lA:
29.8		 3l4dA-3p3lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ALA A 107
ALA A 109
THR A  85
LEU A 213
 None
 0.97A 3l4dA-3p5mA:
undetectable		 3l4dA-3p5mA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 TYR A 167
ALA A 286
ALA A 290
THR A 294
 None
 0.90A 3l4dA-3pkoA:
undetectable		 3l4dA-3pkoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ALA A  48
ALA A  52
THR A  56
LEU A  38
 NAI  A 500 ( 3.9A)
None
None
None
 0.96A 3l4dA-3q2kA:
undetectable		 3l4dA-3q2kA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		4 PHE A  79
ALA A  84
ALA A  88
THR A  92
 None
 0.54A 3l4dA-3qtaA:
undetectable		 3l4dA-3qtaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		4 PHE A  79
TYR A  61
ALA A  88
THR A  92
 None
 0.98A 3l4dA-3qtaA:
undetectable		 3l4dA-3qtaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 231
ALA A 253
THR A 485
LEU A 286
 None
 0.90A 3l4dA-3r44A:
undetectable		 3l4dA-3r44A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkr SHORT CHAIN
OXIDOREDUCTASE

(uncultured
bacterium Bio5) 		PF00106
(adh_short) 		4 ALA A 213
ALA A 217
THR A 221
LEU A   4
 None
 0.64A 3l4dA-3rkrA:
undetectable		 3l4dA-3rkrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE C 655
ALA C 811
ALA C 815
THR C 819
 None
 0.81A 3l4dA-3sr6C:
undetectable		 3l4dA-3sr6C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 PHE A 210
ALA A 176
ALA A 191
LEU A 101
 PHE  A 210 ( 1.3A)
ALA  A 176 ( 0.0A)
ALA  A 191 ( 0.0A)
LEU  A 101 ( 0.6A)
 0.93A 3l4dA-3ulkA:
undetectable		 3l4dA-3ulkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 TYR A 440
ALA A 391
ALA A 395
THR A 399
 None
 0.81A 3l4dA-3uonA:
undetectable		 3l4dA-3uonA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		4 PHE A 294
ALA A 245
ALA A 249
LEU A 316
 None
 0.78A 3l4dA-3wiwA:
undetectable		 3l4dA-3wiwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgw PRE-MRNA-SPLICING
FACTOR PRP9

(Saccharomyces
cerevisiae) 		PF12171
(zf-C2H2_jaz)
PF16837
(SF3A3)
PF16958
(PRP9_N) 		5 TYR A 327
PHE A 245
TYR A 324
ALA A 253
ALA A 255
 None
 1.36A 3l4dA-4dgwA:
undetectable		 3l4dA-4dgwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)

(Pseudomonas
stutzeri) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PHE A  52
ALA A  74
ALA A 308
LEU A  19
 None
 0.90A 3l4dA-4e5kA:
undetectable		 3l4dA-4e5kA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A1155
ALA A1085
THR A1009
MET A1118
 None
None
None
CU  A1401 (-2.7A)
 0.90A 3l4dA-4e9xA:
undetectable		 3l4dA-4e9xA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		4 TYR B 408
PHE B 410
ALA B 379
THR B 450
 None
 0.89A 3l4dA-4etpB:
undetectable		 3l4dA-4etpB:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 PHE A 110
TYR A 103
ALA A 287
ALA A 291
THR A 295
 VNT  A 502 (-4.4A)
VNT  A 502 ( 4.8A)
VNT  A 502 ( 3.9A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
 0.82A 3l4dA-4g3jA:
58.3		 3l4dA-4g3jA:
78.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		7 PHE A 110
TYR A 116
ALA A 287
ALA A 291
THR A 295
LEU A 356
MET A 460
 VNT  A 502 (-4.4A)
HEM  A 501 ( 4.5A)
VNT  A 502 ( 3.9A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
VNT  A 502 (-4.9A)
 0.48A 3l4dA-4g3jA:
58.3		 3l4dA-4g3jA:
78.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 TYR A 103
ALA A 288
ALA A 291
THR A 295
LEU A 356
 VNT  A 502 ( 4.8A)
HEM  A 501 (-4.4A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
 1.23A 3l4dA-4g3jA:
58.3		 3l4dA-4g3jA:
78.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		7 TYR A 103
PHE A 110
TYR A 116
ALA A 291
THR A 295
LEU A 356
MET A 460
 VNT  A 502 ( 4.8A)
VNT  A 502 (-4.4A)
HEM  A 501 ( 4.5A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
VNT  A 502 ( 4.5A)
VNT  A 502 (-4.9A)
 0.80A 3l4dA-4g3jA:
58.3		 3l4dA-4g3jA:
78.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 181
ALA A 215
ALA A 219
THR A 251
LEU A 227
 None
 1.37A 3l4dA-4hnlA:
undetectable		 3l4dA-4hnlA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz4 GLUTATHIONE-S-TRANSF
ERASE

(Actinobacillus
pleuropneumoniae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ALA A 193
ALA A 197
THR A 201
LEU A  30
 None
 0.72A 3l4dA-4hz4A:
undetectable		 3l4dA-4hz4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 TYR A 275
ALA A  57
ALA A  60
LEU A 308
 None
 0.98A 3l4dA-4iwhA:
undetectable		 3l4dA-4iwhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		4 ALA A 306
ALA A 310
THR A 314
LEU A 339
 None
 0.89A 3l4dA-4j9uA:
undetectable		 3l4dA-4j9uA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		4 TYR A 109
THR A  73
LEU A  37
MET A  92
 None
 0.86A 3l4dA-4jqsA:
undetectable		 3l4dA-4jqsA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 298
ALA A 504
ALA A 305
LEU A 313
 None
 0.95A 3l4dA-4jsoA:
undetectable		 3l4dA-4jsoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 PHE A  82
ALA A 152
ALA A 155
LEU A 198
 None
 0.98A 3l4dA-4jz6A:
undetectable		 3l4dA-4jz6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		4 PHE A  36
TYR A  41
ALA A 226
THR A 209
 None
 0.95A 3l4dA-4lruA:
undetectable		 3l4dA-4lruA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 PHE A 141
ALA A 117
ALA A 360
LEU A 266
 None
 0.94A 3l4dA-4mm0A:
30.1		 3l4dA-4mm0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxw LYMPHOTOXIN-BETA

(Homo sapiens) 		no annotation 4 TYR Y 136
ALA Y  89
THR Y 117
LEU Y 125
 None
 0.93A 3l4dA-4mxwY:
undetectable		 3l4dA-4mxwY:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 TYR A 244
TYR A 241
THR A  51
LEU A 257
 None
None
CL  A 300 (-4.0A)
None
 0.58A 3l4dA-4n4pA:
undetectable		 3l4dA-4n4pA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		4 TYR A 189
PHE A 277
TYR A 274
ALA A 125
 None
 0.91A 3l4dA-4nmyA:
undetectable		 3l4dA-4nmyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Saccharomyces
cerevisiae) 		PF00078
(RVT_1) 		4 TYR A 298
PHE A 302
TYR A 299
ALA A 268
 None
 0.85A 3l4dA-4ol8A:
undetectable		 3l4dA-4ol8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 TYR A 340
ALA A 343
ALA A 346
LEU A 368
 None
 0.96A 3l4dA-4tmuA:
undetectable		 3l4dA-4tmuA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 TYR A 543
ALA A 494
ALA A 498
THR A 502
 None
 0.82A 3l4dA-4u14A:
undetectable		 3l4dA-4u14A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 139
TYR A 145
ALA A 311
THR A 315
 VFV  A 580 (-4.2A)
HEM  A 540 (-4.5A)
HEM  A 540 ( 3.4A)
HEM  A 540 (-3.6A)
 0.86A 3l4dA-4uhiA:
37.5		 3l4dA-4uhiA:
35.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uym 14-ALPHA STEROL
DEMETHYLASE

(Aspergillus
fumigatus) 		PF00067
(p450) 		4 TYR A 122
TYR A 136
ALA A 303
ALA A 307
 VOR  A 590 (-3.8A)
HEM  A 580 (-4.6A)
VOR  A 590 ( 4.4A)
VOR  A 590 ( 4.0A)
 0.69A 3l4dA-4uymA:
41.4		 3l4dA-4uymA:
33.60