SIMILAR PATTERNS OF AMINO ACIDS FOR 3L35_K_DHIK3_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by2 MAC-2 BINDING
PROTEIN

(Homo sapiens) 		PF00530
(SRCR) 		3 LEU A  37
TRP A  35
GLY A 102
 None
 0.77A 3l35B-1by2A:
undetectable
3l35K-1by2A:
undetectable		 3l35B-1by2A:
9.40
3l35K-1by2A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		3 LEU A 718
TRP A 518
GLY A 519
 None
ANP  A   1 (-4.9A)
None
 0.77A 3l35B-1d2nA:
undetectable
3l35K-1d2nA:
undetectable		 3l35B-1d2nA:
12.96
3l35K-1d2nA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		3 LEU A 222
TRP A 225
GLY A 276
 None
 0.81A 3l35B-1f0iA:
undetectable
3l35K-1f0iA:
undetectable		 3l35B-1f0iA:
6.63
3l35K-1f0iA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 LEU A 256
TRP A 259
GLY A 230
 None
 0.54A 3l35B-1g0dA:
undetectable
3l35K-1g0dA:
undetectable		 3l35B-1g0dA:
5.22
3l35K-1g0dA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k61 MATING-TYPE PROTEIN
ALPHA-2

(Saccharomyces
cerevisiae) 		PF00046
(Homeobox) 		3 LEU A 144
TRP A 147
GLY A 161
 None
 0.78A 3l35B-1k61A:
undetectable
3l35K-1k61A:
undetectable		 3l35B-1k61A:
23.64
3l35K-1k61A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1le8 MATING-TYPE PROTEIN
ALPHA-2

(Saccharomyces
cerevisiae) 		PF00046
(Homeobox) 		3 LEU B 144
TRP B 147
GLY B 161
 None
 0.78A 3l35B-1le8B:
1.0
3l35K-1le8B:
undetectable		 3l35B-1le8B:
24.66
3l35K-1le8B:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LEU C 276
TRP C 334
GLY C 342
 None
 0.71A 3l35B-1m1jC:
4.4
3l35K-1m1jC:
undetectable		 3l35B-1m1jC:
13.94
3l35K-1m1jC:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 LEU D 206
TRP D 313
GLY D 314
 None
 0.80A 3l35B-1mhzD:
0.0
3l35K-1mhzD:
undetectable		 3l35B-1mhzD:
6.55
3l35K-1mhzD:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnm PROTEIN (MAT ALPHA-2
TRANSCRIPTIONAL
REPRESSOR)

(Saccharomyces
cerevisiae) 		PF00046
(Homeobox) 		3 LEU C 144
TRP C 147
GLY C 161
 None
 0.63A 3l35B-1mnmC:
undetectable
3l35K-1mnmC:
undetectable		 3l35B-1mnmC:
21.43
3l35K-1mnmC:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 LEU A 256
TRP A 259
GLY A 230
 None
None
CA  A 703 ( 4.4A)
 0.51A 3l35B-1nugA:
undetectable
3l35K-1nugA:
undetectable		 3l35B-1nugA:
4.95
3l35K-1nugA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvp TRANSCRIPTION
INITIATION FACTOR
IIA ALPHA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN

(Homo sapiens;
Homo sapiens) 		PF03153
(TFIIA)
PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C) 		3 LEU B  42
TRP B  46
GLY D  12
 None
 0.73A 3l35B-1nvpB:
undetectable
3l35K-1nvpB:
undetectable		 3l35B-1nvpB:
21.31
3l35K-1nvpB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw0 DNA LIGASE III

(Homo sapiens) 		PF00645
(zf-PARP) 		3 LEU A  73
TRP A  79
GLY A  78
 None
 0.71A 3l35B-1uw0A:
undetectable
3l35K-1uw0A:
undetectable		 3l35B-1uw0A:
18.80
3l35K-1uw0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2) 		3 LEU A 118
TRP A 116
GLY A 207
 None
None
C1N  A1115 (-3.3A)
 0.80A 3l35B-1zcmA:
undetectable
3l35K-1zcmA:
undetectable		 3l35B-1zcmA:
6.62
3l35K-1zcmA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		3 LEU A  66
TRP A  59
GLY A  60
 None
 0.76A 3l35B-2d57A:
undetectable
3l35K-2d57A:
undetectable		 3l35B-2d57A:
9.52
3l35K-2d57A:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		3 LEU A  66
TRP A  59
GLY A  61
 None
 0.79A 3l35B-2d57A:
undetectable
3l35K-2d57A:
undetectable		 3l35B-2d57A:
9.52
3l35K-2d57A:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana) 		PF00071
(Ras) 		3 LEU B 108
TRP B 104
GLY B  17
 None
 0.81A 3l35B-2efeB:
undetectable
3l35K-2efeB:
undetectable		 3l35B-2efeB:
14.37
3l35K-2efeB:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A 103
TRP A  99
GLY A  12
 None
 0.79A 3l35B-2fg5A:
undetectable
3l35K-2fg5A:
undetectable		 3l35B-2fg5A:
12.23
3l35K-2fg5A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 LEU A 115
TRP A 121
GLY A 126
 None
 0.74A 3l35B-2i3aA:
undetectable
3l35K-2i3aA:
undetectable		 3l35B-2i3aA:
7.80
3l35K-2i3aA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		3 LEU A 229
TRP A 227
GLY A 248
 None
 0.76A 3l35B-2ifgA:
undetectable
3l35K-2ifgA:
undetectable		 3l35B-2ifgA:
7.92
3l35K-2ifgA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3x CHROMATIN
MODIFICATION-RELATED
PROTEIN EAF3

(Saccharomyces
cerevisiae) 		PF11717
(Tudor-knot) 		3 LEU A  21
TRP A  84
GLY A  83
 None
 0.79A 3l35B-2k3xA:
undetectable
3l35K-2k3xA:
undetectable		 3l35B-2k3xA:
16.96
3l35K-2k3xA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjq DNAA-RELATED PROTEIN

(Neisseria
meningitidis) 		no annotation 3 LEU A  53
TRP A  56
GLY A  36
 None
 0.72A 3l35B-2kjqA:
undetectable
3l35K-2kjqA:
undetectable		 3l35B-2kjqA:
14.58
3l35K-2kjqA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ky4 PHYCOBILISOME LINKER
POLYPEPTIDE

(Nostoc sp. PCC
7120) 		PF00427
(PBS_linker_poly) 		3 LEU A  48
TRP A  44
GLY A  61
 None
 0.58A 3l35B-2ky4A:
undetectable
3l35K-2ky4A:
undetectable		 3l35B-2ky4A:
16.44
3l35K-2ky4A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0r CALPAIN-9

(Homo sapiens) 		PF00648
(Peptidase_C2) 		3 LEU A 100
TRP A  98
GLY A 189
 None
 0.74A 3l35B-2p0rA:
undetectable
3l35K-2p0rA:
undetectable		 3l35B-2p0rA:
8.79
3l35K-2p0rA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pls CBS DOMAIN PROTEIN

(Chlorobaculum
tepidum) 		PF03471
(CorC_HlyC) 		3 LEU A 409
TRP A 407
GLY A 369
 None
 0.81A 3l35B-2plsA:
undetectable
3l35K-2plsA:
undetectable		 3l35B-2plsA:
21.95
3l35K-2plsA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 LEU A 261
TRP A 264
GLY A 235
 None
 0.46A 3l35B-2q3zA:
undetectable
3l35K-2q3zA:
undetectable		 3l35B-2q3zA:
5.21
3l35K-2q3zA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reu TYPE II RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		no annotation 3 LEU A 218
TRP A 237
GLY A 211
 None
 0.71A 3l35B-2reuA:
undetectable
3l35K-2reuA:
undetectable		 3l35B-2reuA:
10.85
3l35K-2reuA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh0 NUDC
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04969
(CS) 		3 LEU A  54
TRP A  18
GLY A  19
 None
 0.75A 3l35B-2rh0A:
undetectable
3l35K-2rh0A:
undetectable		 3l35B-2rh0A:
15.69
3l35K-2rh0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		3 LEU A 258
TRP A 268
GLY A 267
 None
 0.73A 3l35B-2rmpA:
undetectable
3l35K-2rmpA:
undetectable		 3l35B-2rmpA:
6.37
3l35K-2rmpA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		3 LEU A  31
TRP A  32
GLY A  66
 None
 0.75A 3l35B-2w2sA:
undetectable
3l35K-2w2sA:
undetectable		 3l35B-2w2sA:
13.37
3l35K-2w2sA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		3 LEU A 165
TRP A 168
GLY A 149
 None
 0.79A 3l35B-2wc1A:
undetectable
3l35K-2wc1A:
undetectable		 3l35B-2wc1A:
13.41
3l35K-2wc1A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 LEU A 104
TRP A 282
GLY A 267
 None
 0.73A 3l35B-3b46A:
undetectable
3l35K-3b46A:
undetectable		 3l35B-3b46A:
8.59
3l35K-3b46A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LEU C 276
TRP C 334
GLY C 342
 None
 0.69A 3l35B-3bvhC:
2.1
3l35K-3bvhC:
undetectable		 3l35B-3bvhC:
5.46
3l35K-3bvhC:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxc RIBOSOMAL PROTEIN
L37AE

(Haloarcula
marismortui) 		PF01780
(Ribosomal_L37ae) 		3 LEU Y  47
TRP Y  55
GLY Y  67
 None
 0.72A 3l35B-3cxcY:
undetectable
3l35K-3cxcY:
undetectable		 3l35B-3cxcY:
21.79
3l35K-3cxcY:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		3 LEU A 321
TRP A 275
GLY A 281
 None
 0.79A 3l35B-3e73A:
undetectable
3l35K-3e73A:
undetectable		 3l35B-3e73A:
10.40
3l35K-3e73A:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghg FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LEU C 276
TRP C 334
GLY C 342
 LEU  C 276 ( 0.6A)
TRP  C 334 ( 0.5A)
GLY  C 342 ( 0.0A)
 0.78A 3l35B-3ghgC:
4.1
3l35K-3ghgC:
undetectable		 3l35B-3ghgC:
7.20
3l35K-3ghgC:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		3 LEU A 373
TRP A 304
GLY A 303
 None
 0.78A 3l35B-3h75A:
undetectable
3l35K-3h75A:
undetectable		 3l35B-3h75A:
9.45
3l35K-3h75A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG

(Homo sapiens) 		PF13424
(TPR_12) 		3 LEU B 458
TRP B 418
GLY B 416
 None
 0.74A 3l35B-3hymB:
undetectable
3l35K-3hymB:
undetectable		 3l35B-3hymB:
6.73
3l35K-3hymB:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0c E2 ENVELOPE
GLYCOPROTEIN

(Venezuelan
equine
encephalitis
virus) 		PF00943
(Alpha_E2_glycop) 		3 LEU B 285
TRP B 330
GLY B 331
 None
 0.79A 3l35B-3j0cB:
1.3
3l35K-3j0cB:
undetectable		 3l35B-3j0cB:
6.78
3l35K-3j0cB:
2.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 LEU A 710
TRP A 510
GLY A 511
 None
 0.81A 3l35B-3j97A:
undetectable
3l35K-3j97A:
undetectable		 3l35B-3j97A:
5.50
3l35K-3j97A:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		3 LEU A1453
TRP A1449
GLY A1441
 None
 0.82A 3l35B-3jbzA:
undetectable
3l35K-3jbzA:
undetectable		 3l35B-3jbzA:
4.33
3l35K-3jbzA:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		3 LEU A 151
TRP A 155
GLY A 140
 EDO  A 170 (-4.9A)
None
None
 0.73A 3l35B-3klbA:
undetectable
3l35K-3klbA:
undetectable		 3l35B-3klbA:
11.11
3l35K-3klbA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		3 LEU A  48
TRP A  27
GLY A  26
 None
 0.77A 3l35B-3m7oA:
undetectable
3l35K-3m7oA:
undetectable		 3l35B-3m7oA:
11.54
3l35K-3m7oA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Vibrio cholerae) 		PF02348
(CTP_transf_3) 		3 LEU A 103
TRP A  32
GLY A  25
 None
 0.75A 3l35B-3oamA:
undetectable
3l35K-3oamA:
undetectable		 3l35B-3oamA:
9.68
3l35K-3oamA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		3 LEU A 163
TRP A 236
GLY A 235
 None
 0.75A 3l35B-3onqA:
undetectable
3l35K-3onqA:
undetectable		 3l35B-3onqA:
14.81
3l35K-3onqA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		3 LEU A 104
TRP A 176
GLY A 179
 None
 0.76A 3l35B-3r7pA:
undetectable
3l35K-3r7pA:
undetectable		 3l35B-3r7pA:
8.92
3l35K-3r7pA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT A

(Escherichia
coli) 		PF00507
(Oxidored_q4) 		3 LEU A  85
TRP A  88
GLY A  99
 None
 0.80A 3l35B-3rkoA:
undetectable
3l35K-3rkoA:
undetectable		 3l35B-3rkoA:
17.74
3l35K-3rkoA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		3 LEU A 317
TRP A 319
GLY A 230
 None
 0.73A 3l35B-3slgA:
undetectable
3l35K-3slgA:
undetectable		 3l35B-3slgA:
7.34
3l35K-3slgA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		3 LEU A  14
TRP A  12
GLY A 252
 None
 0.74A 3l35B-3vv3A:
undetectable
3l35K-3vv3A:
undetectable		 3l35B-3vv3A:
7.93
3l35K-3vv3A:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 LEU A 661
TRP A 664
GLY A 639
 None
 0.64A 3l35B-3w5nA:
undetectable
3l35K-3w5nA:
undetectable		 3l35B-3w5nA:
4.35
3l35K-3w5nA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 LEU A 631
TRP A 634
GLY A 996
 None
 0.80A 3l35B-3w9hA:
1.9
3l35K-3w9hA:
undetectable		 3l35B-3w9hA:
4.44
3l35K-3w9hA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwh (R)-AMINE
TRANSAMINASE

(Arthrobacter
sp. KNK168) 		PF01063
(Aminotran_4) 		3 LEU A  18
TRP A 315
GLY A 286
 None
 0.78A 3l35B-3wwhA:
undetectable
3l35K-3wwhA:
undetectable		 3l35B-3wwhA:
9.06
3l35K-3wwhA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		3 LEU A 840
TRP A 843
GLY A 281
 None
 0.56A 3l35B-4am6A:
undetectable
3l35K-4am6A:
undetectable		 3l35B-4am6A:
5.25
3l35K-4am6A:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 LEU A 256
TRP A 259
GLY A  12
 None
 0.73A 3l35B-4drtA:
undetectable
3l35K-4drtA:
undetectable		 3l35B-4drtA:
7.76
3l35K-4drtA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		3 LEU A 193
TRP A 210
GLY A  59
 None
 0.81A 3l35B-4eb5A:
undetectable
3l35K-4eb5A:
undetectable		 3l35B-4eb5A:
8.24
3l35K-4eb5A:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF01398
(JAB) 		3 LEU A 147
TRP A 146
GLY A 144
 None
 0.78A 3l35B-4f7oA:
undetectable
3l35K-4f7oA:
undetectable		 3l35B-4f7oA:
9.73
3l35K-4f7oA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		3 LEU A 583
TRP A 586
GLY A  61
 CL  A 711 ( 4.7A)
None
None
 0.68A 3l35B-4fo0A:
undetectable
3l35K-4fo0A:
undetectable		 3l35B-4fo0A:
5.70
3l35K-4fo0A:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		3 LEU A 123
TRP A 165
GLY A 164
 None
 0.73A 3l35B-4guzA:
undetectable
3l35K-4guzA:
undetectable		 3l35B-4guzA:
6.74
3l35K-4guzA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		3 LEU A  20
TRP A  23
GLY A  66
 None
 0.79A 3l35B-4jerA:
undetectable
3l35K-4jerA:
undetectable		 3l35B-4jerA:
14.29
3l35K-4jerA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 3 LEU C 105
TRP C 114
GLY C  66
 None
 0.58A 3l35B-4k49C:
undetectable
3l35K-4k49C:
undetectable		 3l35B-4k49C:
16.91
3l35K-4k49C:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k4d PROOFREADING
THIOESTERASE ENTH

(Escherichia
coli) 		PF03061
(4HBT) 		3 LEU A 105
TRP A 114
GLY A  66
 None
 0.64A 3l35B-4k4dA:
undetectable
3l35K-4k4dA:
undetectable		 3l35B-4k4dA:
12.41
3l35K-4k4dA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq0 LAGLIDADG HOMING
ENDONUCLEASE

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		3 LEU A 102
TRP A 173
GLY A 176
 None
 0.79A 3l35B-4lq0A:
undetectable
3l35K-4lq0A:
undetectable		 3l35B-4lq0A:
9.83
3l35K-4lq0A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		3 LEU A  20
TRP A  23
GLY A  95
 None
 0.45A 3l35B-4o6qA:
undetectable
3l35K-4o6qA:
undetectable		 3l35B-4o6qA:
10.40
3l35K-4o6qA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		3 LEU A 148
TRP A 145
GLY A  81
 MAV  A 803 ( 4.8A)
None
None
 0.67A 3l35B-4ojzA:
undetectable
3l35K-4ojzA:
undetectable		 3l35B-4ojzA:
5.66
3l35K-4ojzA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		3 LEU A 122
TRP A  42
GLY A  43
 None
 0.75A 3l35B-4or8A:
undetectable
3l35K-4or8A:
undetectable		 3l35B-4or8A:
10.94
3l35K-4or8A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		3 LEU A 223
TRP A 226
GLY A 264
 None
 0.59A 3l35B-4otkA:
undetectable
3l35K-4otkA:
undetectable		 3l35B-4otkA:
7.32
3l35K-4otkA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		3 LEU A 148
TRP A 146
GLY A 141
 None
 0.74A 3l35B-4p7wA:
undetectable
3l35K-4p7wA:
undetectable		 3l35B-4p7wA:
11.67
3l35K-4p7wA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9g 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		3 LEU A  65
TRP A  91
GLY A  92
 None
 0.79A 3l35B-4p9gA:
undetectable
3l35K-4p9gA:
undetectable		 3l35B-4p9gA:
18.97
3l35K-4p9gA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		3 LEU A 449
TRP A 468
GLY A 442
 None
 0.72A 3l35B-4pxgA:
undetectable
3l35K-4pxgA:
undetectable		 3l35B-4pxgA:
6.48
3l35K-4pxgA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		3 LEU A 201
TRP A 162
GLY A 161
 None
 0.74A 3l35B-4ql0A:
undetectable
3l35K-4ql0A:
undetectable		 3l35B-4ql0A:
11.37
3l35K-4ql0A:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		3 LEU A  95
TRP A 169
GLY A 172
 None
 0.81A 3l35B-4yisA:
undetectable
3l35K-4yisA:
undetectable		 3l35B-4yisA:
10.69
3l35K-4yisA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 LEU A1452
TRP A1424
GLY A1425
 None
 0.69A 3l35B-4yknA:
undetectable
3l35K-4yknA:
undetectable		 3l35B-4yknA:
3.04
3l35K-4yknA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		3 LEU A 413
TRP A 411
GLY A 143
 None
 0.71A 3l35B-4yn5A:
undetectable
3l35K-4yn5A:
undetectable		 3l35B-4yn5A:
7.87
3l35K-4yn5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		3 LEU A 157
TRP A 160
GLY A 200
 None
 0.77A 3l35B-5aexA:
undetectable
3l35K-5aexA:
undetectable		 3l35B-5aexA:
5.52
3l35K-5aexA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		3 LEU A 152
TRP A 153
GLY A 168
 None
 0.72A 3l35B-5azbA:
undetectable
3l35K-5azbA:
undetectable		 3l35B-5azbA:
8.21
3l35K-5azbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		3 LEU A  65
TRP A  91
GLY A  92
 None
 0.80A 3l35B-5bpxA:
undetectable
3l35K-5bpxA:
undetectable		 3l35B-5bpxA:
11.84
3l35K-5bpxA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		3 LEU A 296
TRP A 292
GLY A 319
 None
 0.73A 3l35B-5bqkA:
undetectable
3l35K-5bqkA:
undetectable		 3l35B-5bqkA:
8.12
3l35K-5bqkA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		3 LEU A 130
TRP A 133
GLY A 111
 None
 0.64A 3l35B-5e2gA:
undetectable
3l35K-5e2gA:
undetectable		 3l35B-5e2gA:
7.87
3l35K-5e2gA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5o I-SMAMI LAGLIDADG
ENDONUCLEASE

(Sordaria
macrospora) 		PF00961
(LAGLIDADG_1) 		3 LEU A  99
TRP A 171
GLY A 174
 None
 0.82A 3l35B-5e5oA:
undetectable
3l35K-5e5oA:
undetectable		 3l35B-5e5oA:
9.86
3l35K-5e5oA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul AYC08
PROTEIN TRANSLOCASE
SUBUNIT SECY

(Vicugna pacos;
Geobacillus
thermodenitrificans) 		PF07686
(V-set)
PF00344
(SecY) 		3 LEU Y  46
TRP V 107
GLY V 108
 None
 0.80A 3l35B-5eulY:
undetectable
3l35K-5eulY:
undetectable		 3l35B-5eulY:
8.08
3l35K-5eulY:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LEU A 404
TRP A 571
GLY A 553
 None
 0.81A 3l35B-5fjiA:
undetectable
3l35K-5fjiA:
undetectable		 3l35B-5fjiA:
3.83
3l35K-5fjiA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2

(Homo sapiens;
Homo sapiens) 		PF03153
(TFIIA)
PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C) 		3 LEU B  42
TRP B  46
GLY D  12
 None
 0.75A 3l35B-5furB:
undetectable
3l35K-5furB:
undetectable		 3l35B-5furB:
17.02
3l35K-5furB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gka CAPSID PROTEIN VP0

(Aichivirus A) 		PF00073
(Rhv) 		3 LEU B 207
TRP B 217
GLY B 198
 None
 0.62A 3l35B-5gkaB:
undetectable
3l35K-5gkaB:
undetectable		 3l35B-5gkaB:
7.74
3l35K-5gkaB:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		3 LEU A 405
TRP A 103
GLY A 100
 None
 0.77A 3l35B-5i6zA:
undetectable
3l35K-5i6zA:
undetectable		 3l35B-5i6zA:
7.13
3l35K-5i6zA:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 LEU A 791
TRP A 777
GLY A 782
 None
 0.79A 3l35B-5j6sA:
undetectable
3l35K-5j6sA:
undetectable		 3l35B-5j6sA:
6.27
3l35K-5j6sA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 3 LEU A 310
TRP A 313
GLY A 264
 None
 0.75A 3l35B-5oq3A:
undetectable
3l35K-5oq3A:
undetectable		 3l35B-5oq3A:
7.94
3l35K-5oq3A:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2h I-ONUI_E-HTCRA

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		3 LEU A  99
TRP A 170
GLY A 173
 None
 0.77A 3l35B-5t2hA:
undetectable
3l35K-5t2hA:
undetectable		 3l35B-5t2hA:
9.36
3l35K-5t2hA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2n I-ONUI_E-AG007820

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		3 LEU A  99
TRP A 170
GLY A 173
 None
 0.82A 3l35B-5t2nA:
undetectable
3l35K-5t2nA:
undetectable		 3l35B-5t2nA:
10.27
3l35K-5t2nA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thg I-ONUI_E-HCCR5

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		3 LEU A  99
TRP A 170
GLY A 173
 None
 0.77A 3l35B-5thgA:
undetectable
3l35K-5thgA:
undetectable		 3l35B-5thgA:
10.38
3l35K-5thgA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 LEU A 225
TRP A 228
GLY A 203
 None
 0.81A 3l35B-5vatA:
undetectable
3l35K-5vatA:
undetectable		 3l35B-5vatA:
7.08
3l35K-5vatA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 3 LEU A  89
TRP A 266
GLY A 251
 None
 0.76A 3l35B-5vehA:
undetectable
3l35K-5vehA:
undetectable		 3l35B-5vehA:
6.62
3l35K-5vehA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 3 LEU A 114
TRP A 292
GLY A 277
 None
 0.76A 3l35B-5verA:
undetectable
3l35K-5verA:
undetectable		 3l35B-5verA:
8.03
3l35K-5verA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5v GD

(Suid
alphaherpesvirus
1) 		PF01537
(Herpes_glycop_D) 		3 LEU A 109
TRP A  98
GLY A 150
 None
 0.74A 3l35B-5x5vA:
undetectable
3l35K-5x5vA:
undetectable		 3l35B-5x5vA:
5.72
3l35K-5x5vA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 LEU A 452
TRP A 424
GLY A 425
 None
 0.73A 3l35B-5xgjA:
undetectable
3l35K-5xgjA:
undetectable		 3l35B-5xgjA:
undetectable
3l35K-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 3 LEU B 184
TRP B 181
GLY B 177
 None
 0.70A 3l35B-5y7rB:
undetectable
3l35K-5y7rB:
undetectable		 3l35B-5y7rB:
undetectable
3l35K-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbk PUTATIVE CYTOKININ
RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Pseudomonas
aeruginosa) 		no annotation 3 LEU A 178
TRP A 181
GLY A 163
 None
 0.80A 3l35B-5zbkA:
undetectable
3l35K-5zbkA:
undetectable		 3l35B-5zbkA:
undetectable
3l35K-5zbkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 3 LEU A 357
TRP A 355
GLY A 421
 None
 0.64A 3l35B-5ze3A:
undetectable
3l35K-5ze3A:
undetectable		 3l35B-5ze3A:
undetectable
3l35K-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwf -

(-) 		no annotation 3 LEU A 279
TRP A 282
GLY A 196
 None
 0.63A 3l35B-6bwfA:
3.7
3l35K-6bwfA:
undetectable		 3l35B-6bwfA:
undetectable
3l35K-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 3 LEU A 311
TRP A 275
GLY A 276
 None
 0.59A 3l35B-6eo5A:
undetectable
3l35K-6eo5A:
undetectable		 3l35B-6eo5A:
undetectable
3l35K-6eo5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etx DNA HELICASE INO80

(Homo sapiens) 		no annotation 3 LEU G 916
TRP G 913
GLY G1053
 None
 0.76A 3l35B-6etxG:
undetectable
3l35K-6etxG:
undetectable		 3l35B-6etxG:
undetectable
3l35K-6etxG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 3 LEU J 726
TRP J 729
GLY J  71
 None
 0.61A 3l35B-6fhsJ:
undetectable
3l35K-6fhsJ:
undetectable		 3l35B-6fhsJ:
undetectable
3l35K-6fhsJ:
undetectable