SIMILAR PATTERNS OF AMINO ACIDS FOR 3L2V_A_RLTA397

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		4 ASP A 105
ASP A 153
GLN A 154
PRO A 134
 None
 1.19A 3l2vA-1bs9A:
undetectable		 3l2vA-1bs9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		4 ASP A 105
GLN A 154
PRO A 134
GLU A  94
 None
 0.89A 3l2vA-1bs9A:
undetectable		 3l2vA-1bs9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ASP A 448
ASP A 539
GLN A 614
GLU A 446
 None
CBS  A1001 (-3.9A)
None
None
 1.16A 3l2vA-1c7tA:
undetectable		 3l2vA-1c7tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuf CENTROMERE ABP1
PROTEIN

(Schizosaccharomyces
pombe) 		PF03221
(HTH_Tnp_Tc5) 		4 ASP A 120
GLN A 121
PRO A 116
GLU A 117
 None
 0.82A 3l2vA-1iufA:
undetectable		 3l2vA-1iufA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae) 		PF01569
(PAP2) 		4 ASP A  45
GLN A  46
TYR A  49
GLN A  51
 None
 1.23A 3l2vA-1iw8A:
undetectable		 3l2vA-1iw8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jql DNA POLYMERASE III,
DELTA SUBUNIT

(Escherichia
coli) 		PF06144
(DNA_pol3_delta) 		4 ASP B  27
GLN B 140
TYR B   5
GLU B  33
 None
 1.27A 3l2vA-1jqlB:
undetectable		 3l2vA-1jqlB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASP A 515
ASP A 513
TYR A 474
GLN A 477
 None
 1.08A 3l2vA-1ot5A:
0.1		 3l2vA-1ot5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ASP A 167
ASP A 166
TYR A 377
GLN A 375
 None
 1.26A 3l2vA-1pgjA:
undetectable		 3l2vA-1pgjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 ASP A 562
GLN A 561
PRO A 601
GLU A 648
 None
 1.21A 3l2vA-1qb4A:
1.1		 3l2vA-1qb4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 ASP A 195
GLN A 129
GLN A 180
GLU A 177
 None
FMT  A3013 (-4.9A)
None
None
 0.84A 3l2vA-1r4pA:
undetectable		 3l2vA-1r4pA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6t SH3 DOMAIN-BINDING
GLUTAMIC
ACID-RICH-LIKE
PROTEIN

(Homo sapiens) 		PF04908
(SH3BGR) 		4 ASP A  79
ASP A  77
PRO A  66
GLN A  19
 None
 1.26A 3l2vA-1u6tA:
undetectable		 3l2vA-1u6tA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 ASP A 490
ASP A 546
TYR A 494
GLU A 550
 None
 1.20A 3l2vA-1ulvA:
undetectable		 3l2vA-1ulvA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		4 ASP A  87
GLN A 115
TYR A 250
GLU A  89
 None
 1.22A 3l2vA-1un1A:
undetectable		 3l2vA-1un1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3p CPSRP43

(Arabidopsis
thaliana) 		PF00385
(Chromo) 		4 ASP A  36
PRO A  34
GLN A  49
GLU A  33
 None
 1.20A 3l2vA-1x3pA:
undetectable		 3l2vA-1x3pA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 ASP A 268
TYR A 225
GLN A 293
GLU A 269
 None
 1.27A 3l2vA-1xeuA:
undetectable		 3l2vA-1xeuA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ASP E 202
ASP E 204
GLN E 206
GLN E 197
 None
 1.20A 3l2vA-2bg9E:
undetectable		 3l2vA-2bg9E:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9x SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT B

(Starkeya
novella) 		no annotation 4 ASP B 569
GLN B 526
PRO B 520
GLN B 519
 None
 1.18A 3l2vA-2c9xB:
undetectable		 3l2vA-2c9xB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckk KIN17

(Homo sapiens) 		no annotation 4 ASP A 122
GLN A  16
TYR A  13
GLU A 121
 None
 1.16A 3l2vA-2ckkA:
5.9		 3l2vA-2ckkA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 ASP A 163
ASP A 166
PRO A 168
GLN A 169
 None
 1.18A 3l2vA-2hauA:
undetectable		 3l2vA-2hauA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip6 PAPB

(Pediococcus
pentosaceus) 		PF08951
(EntA_Immun) 		4 GLN A  11
PRO A  54
GLN A  57
GLU A  55
 None
 0.95A 3l2vA-2ip6A:
undetectable		 3l2vA-2ip6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgp LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a) 		4 ASP A 147
ASP A 151
PRO A 150
GLU A 158
 CA  A 215 (-3.6A)
CA  A 215 (-3.2A)
None
CA  A 215 (-3.8A)
 1.17A 3l2vA-2lgpA:
undetectable		 3l2vA-2lgpA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ASP A 270
GLN A 225
PRO A 264
GLN A 262
 None
 1.09A 3l2vA-2om5A:
undetectable		 3l2vA-2om5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		4 ASP A 243
GLN A 240
GLN A 201
GLU A 251
 None
 1.09A 3l2vA-2q0fA:
undetectable		 3l2vA-2q0fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		4 ASP A 193
GLN A 192
TYR A 227
GLN A 256
 None
 1.20A 3l2vA-2qgqA:
undetectable		 3l2vA-2qgqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2a UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF05707
(Zot) 		4 ASP A 134
GLN A 135
PRO A  98
GLN A  94
 None
 1.10A 3l2vA-2r2aA:
undetectable		 3l2vA-2r2aA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 GLN A 174
PRO A 177
GLN A 178
GLU A 160
 NI  A1231 ( 4.7A)
None
None
None
 1.09A 3l2vA-2vtcA:
undetectable		 3l2vA-2vtcA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ASP A 101
GLN A 103
TYR A  94
GLU A  44
 None
 1.16A 3l2vA-2x3kA:
undetectable		 3l2vA-2x3kA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x6n INTEGRASE

(Simian foamy
virus) 		PF00665
(rve) 		4 ASP A 128
ASP A 185
GLN A 186
GLN A 215
 MN  A1197 (-2.7A)
MN  A1197 (-2.6A)
None
None
 1.13A 3l2vA-2x6nA:
19.9		 3l2vA-2x6nA:
97.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 ASP A 882
ASP A 886
PRO A 884
GLN A 935
 None
 1.16A 3l2vA-2ya1A:
1.8		 3l2vA-2ya1A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ASP A 427
ASP A 431
PRO A 429
GLN A 480
 CA  A1691 (-2.8A)
CA  A1691 (-2.2A)
None
None
 1.12A 3l2vA-2ya2A:
undetectable		 3l2vA-2ya2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yet GH61 ISOZYME A

(Thermoascus
aurantiacus) 		PF03443
(Glyco_hydro_61) 		4 GLN A 173
PRO A 176
GLN A 177
GLU A 159
 CU  A 301 ( 4.5A)
None
None
None
 1.10A 3l2vA-2yetA:
undetectable		 3l2vA-2yetA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 ASP A 665
GLN A 700
GLN A 709
GLU A 694
 None
CA  A2074 ( 4.5A)
None
None
 1.24A 3l2vA-2yocA:
undetectable		 3l2vA-2yocA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ASP A 421
GLN A 422
TYR A 258
PRO A 235
 None
 0.94A 3l2vA-3a24A:
undetectable		 3l2vA-3a24A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		4 ASP A 275
ASP A 117
PRO A 211
GLU A 247
 MG  A   1 (-3.3A)
MG  A   1 ( 4.7A)
None
MG  A   1 (-2.6A)
 1.27A 3l2vA-3cuxA:
undetectable		 3l2vA-3cuxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF01359
(Transposase_1) 		4 ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
 0.54A 3l2vA-3f2kA:
10.5		 3l2vA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ASP A 906
ASP A 910
PRO A 908
GLN A 957
 CA  A   4 (-3.0A)
CA  A   4 (-2.3A)
None
None
 1.07A 3l2vA-3fawA:
2.0		 3l2vA-3fawA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		4 ASP A   5
GLN A   6
PRO A   3
GLN A   1
 None
 0.89A 3l2vA-3grhA:
undetectable		 3l2vA-3grhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4q APC40078

(Oleispira
antarctica) 		PF00719
(Pyrophosphatase) 		4 ASP A 103
ASP A  71
TYR A  58
GLU A 104
 NA  A 176 (-2.8A)
NA  A 176 (-3.0A)
None
None
 1.25A 3l2vA-3i4qA:
undetectable		 3l2vA-3i4qA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 ASP A 320
GLN A 321
TYR A 324
GLU A 254
 None
 1.14A 3l2vA-3i5bA:
undetectable		 3l2vA-3i5bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 ASP A 737
TYR A 728
GLN A 663
GLU A 416
 None
 1.17A 3l2vA-3j09A:
undetectable		 3l2vA-3j09A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7l ATRAGIN

(Naja atra) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASP A 489
ASP A 474
PRO A 476
GLU A 477
 CA  A 702 (-3.1A)
CA  A 702 (-2.9A)
None
CA  A 702 (-2.3A)
 1.17A 3l2vA-3k7lA:
undetectable		 3l2vA-3k7lA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASP A 472
ASP A 457
PRO A 459
GLU A 460
 CA  A 703 (-3.2A)
CA  A 703 (-3.2A)
None
CA  A 703 (-2.5A)
 1.24A 3l2vA-3k7nA:
undetectable		 3l2vA-3k7nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		4 ASP A 707
GLN A 706
TYR A 710
GLN A 457
 None
 1.06A 3l2vA-3la6A:
undetectable		 3l2vA-3la6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		4 ASP B  76
ASP B  73
GLN B  72
GLN B 198
 CA  B 552 (-3.4A)
CA  B 552 (-2.7A)
None
None
 1.25A 3l2vA-3ml0B:
undetectable		 3l2vA-3ml0B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpo PREDICTED HYDROLASE
OF THE HAD
SUPERFAMILY

(Lactobacillus
brevis) 		PF08282
(Hydrolase_3) 		4 TYR A 185
PRO A 159
GLN A 160
GLU A 163
 None
 1.26A 3l2vA-3mpoA:
undetectable		 3l2vA-3mpoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 ASP B  58
ASP B  56
GLN B  55
GLU B  60
 None
None
NAG  B 338 (-4.3A)
None
 0.97A 3l2vA-3o4oB:
undetectable		 3l2vA-3o4oB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ASP A  98
GLN A  95
GLN A 103
GLU A 101
 None
 0.94A 3l2vA-3o5aA:
undetectable		 3l2vA-3o5aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovz CATHEPSIN K

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 GLN A  76
TYR A 110
PRO A 213
GLN A  37
 None
 1.24A 3l2vA-3ovzA:
undetectable		 3l2vA-3ovzA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oyn PFV INTEGRASE

(Simian foamy
virus) 		PF00665
(rve) 		7 ASP A 128
ASP A 185
GLN A 186
TYR A 212
PRO A 214
GLN A 215
GLU A 221
 MG  A 396 (-2.6A)
MG  A 396 ( 2.7A)
None
ZZX  A 398 ( 4.0A)
ZZX  A 398 (-4.1A)
ZZX  A 398 (-3.9A)
MG  A 397 ( 1.8A)
 0.78A 3l2vA-3oynA:
43.1		 3l2vA-3oynA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		4 ASP A 347
ASP A 263
TYR A 265
PRO A 266
 None
 1.18A 3l2vA-3pshA:
undetectable		 3l2vA-3pshA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2w CADHERIN-2

(Mus musculus) 		PF00028
(Cadherin) 		4 ASP A 218
ASP A 250
GLN A 184
GLU A 119
 CA  A 604 ( 2.7A)
CA  A 605 ( 3.3A)
None
CA  A 604 ( 2.7A)
 1.06A 3l2vA-3q2wA:
undetectable		 3l2vA-3q2wA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swj PUTATIVE
UNCHARACTERIZED
PROTEIN

(Campylobacter
jejuni) 		PF01243
(Putative_PNPOx)
PF10615
(DUF2470) 		4 ASP A 187
GLN A 184
GLN A 192
GLU A 190
 None
 1.21A 3l2vA-3swjA:
undetectable		 3l2vA-3swjA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		4 ASP A   9
ASP A  14
GLN A  41
GLU A  42
 CA  A 400 (-3.1A)
CA  A 400 (-2.3A)
None
None
 1.18A 3l2vA-3t8iA:
undetectable		 3l2vA-3t8iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		4 ASP A   9
ASP A  14
GLN A  42
GLU A  43
 NA  A 401 (-3.2A)
NA  A 401 (-2.6A)
None
None
 1.22A 3l2vA-3t8jA:
undetectable		 3l2vA-3t8jA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8s INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 ASP A 180
GLN A 116
PRO A 165
GLN A 164
 None
 1.21A 3l2vA-3t8sA:
undetectable		 3l2vA-3t8sA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uv9 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Macaca mulatta) 		PF00622
(SPRY) 		4 GLN A 398
TYR A 389
GLN A 393
GLU A 392
 None
 1.07A 3l2vA-3uv9A:
undetectable		 3l2vA-3uv9A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5v FERREDOXIN

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ASP A 307
GLN A 308
GLN A  23
GLU A  24
 None
 1.10A 3l2vA-3w5vA:
undetectable		 3l2vA-3w5vA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		4 ASP A  15
ASP A  63
GLN A  62
GLN A  68
 None
 1.22A 3l2vA-4aigA:
undetectable		 3l2vA-4aigA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ASP E 202
ASP E 204
GLN E 206
GLN E 197
 None
 1.19A 3l2vA-4aq9E:
undetectable		 3l2vA-4aq9E:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens) 		PF00531
(Death)
PF00791
(ZU5) 		4 ASP A1113
PRO A1115
GLN A1116
GLU A1067
 None
 1.00A 3l2vA-4d8oA:
undetectable		 3l2vA-4d8oA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpk COLLAGENASE

(Hathewaya
histolytica) 		PF04151
(PPC) 		4 ASP A 927
ASP A 904
TYR A 931
GLU A 901
 CA  A1101 ( 2.8A)
CA  A1101 (-3.2A)
None
CA  A1101 ( 2.2A)
 1.26A 3l2vA-4hpkA:
undetectable		 3l2vA-4hpkA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 178
PRO A 166
GLN A 169
GLU A 167
 None
 1.20A 3l2vA-4jsoA:
undetectable		 3l2vA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 179
PRO A 166
GLN A 169
GLU A 167
 None
 1.17A 3l2vA-4jsoA:
undetectable		 3l2vA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		4 ASP A 387
ASP A 366
GLN A 365
GLU A 213
 MN  A 606 (-2.5A)
MN  A 606 (-4.5A)
None
MN  A 606 ( 3.0A)
 1.25A 3l2vA-4kqbA:
undetectable		 3l2vA-4kqbA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		4 TYR A 357
PRO A 361
GLN A 360
GLU A 364
 None
 1.27A 3l2vA-4lisA:
undetectable		 3l2vA-4lisA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lps HYDROGENASE/UREASE
NICKEL INCORPORATION
PROTEIN HYPB

(Helicobacter
pylori) 		PF02492
(cobW) 		4 ASP A  86
ASP A  80
GLN A  82
GLU A  78
 MG  A 301 ( 2.5A)
PO4  A 303 (-3.8A)
None
MG  A 301 ( 4.8A)
 1.13A 3l2vA-4lpsA:
undetectable		 3l2vA-4lpsA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7i 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 ASP A 226
GLN A 131
TYR A 132
GLN A 228
 PO4  A 402 (-4.8A)
None
None
None
 1.04A 3l2vA-4o7iA:
undetectable		 3l2vA-4o7iA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 ASP A 451
GLN A 446
GLN A 435
GLU A 432
 None
 1.16A 3l2vA-4oerA:
undetectable		 3l2vA-4oerA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN

(Streptococcus
pyogenes) 		PF16364
(Antigen_C) 		4 ASP A1108
ASP A1006
GLN A 975
TYR A1139
 None
 1.19A 3l2vA-4ofqA:
undetectable		 3l2vA-4ofqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj2 PUTATIVE EXPORTED
PROTEIN

(Aeromonas
hydrophila) 		PF16743
(PliI) 		4 ASP A  65
GLN A  66
TYR A  55
PRO A  63
 GOL  A 202 (-4.7A)
GOL  A 202 (-3.9A)
None
None
 1.21A 3l2vA-4pj2A:
undetectable		 3l2vA-4pj2A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 ASP A 291
PRO A 289
GLN A 288
GLU A 292
 None
 1.17A 3l2vA-4q38A:
undetectable		 3l2vA-4q38A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN

(Zobellia
galactanivorans) 		no annotation 4 ASP A 231
GLN A 259
TYR A 233
PRO A 232
 3DY  A 521 (-2.6A)
None
None
None
 1.20A 3l2vA-4u6dA:
undetectable		 3l2vA-4u6dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ASP A 172
ASP A 170
GLN A 169
TYR A  34
 None
 1.15A 3l2vA-4wa8A:
undetectable		 3l2vA-4wa8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpm PROTEIN PCDHAC2

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ASP A  64
TYR A  47
GLN A  10
GLU A   8
 CA  A 804 (-3.2A)
None
None
CA  A 805 ( 3.0A)
 1.23A 3l2vA-4zpmA:
undetectable		 3l2vA-4zpmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 ASP A 230
GLN A 212
PRO A 235
GLN A 238
 None
 1.16A 3l2vA-5bwiA:
undetectable		 3l2vA-5bwiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 GLN A 416
TYR A 415
PRO A 411
GLN A 443
 None
 1.26A 3l2vA-5by3A:
undetectable		 3l2vA-5by3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X

(synthetic
construct) 		PF01498
(HTH_Tnp_Tc3_2)
PF13358
(DDE_3) 		4 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.74A 3l2vA-5cr4A:
11.2		 3l2vA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
equi) 		PF08341
(TED) 		4 ASP D  47
GLN D  48
TYR D  16
PRO D  46
 None
 1.20A 3l2vA-5dcqD:
undetectable		 3l2vA-5dcqD:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejk GAG-PRO-POL
POLYPROTEIN

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ASP A  64
ASP A 121
GLN A 151
GLU A 157
 None
 0.52A 3l2vA-5ejkA:
18.9		 3l2vA-5ejkA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erp DESMOCOLLIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP A 465
ASP A 434
GLN A 433
GLU A 401
 CA  A 817 ( 3.2A)
CA  A 817 (-3.0A)
None
CA  A 817 ( 2.5A)
 1.10A 3l2vA-5erpA:
undetectable		 3l2vA-5erpA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 ASP B  16
GLN B  11
PRO B  14
GLN B  57
 None
 1.21A 3l2vA-5gs2B:
undetectable		 3l2vA-5gs2B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsb RNA POLYMERASE

(Andes
orthohantavirus) 		no annotation 4 ASP A  97
ASP A  40
GLN A  41
GLU A  54
 MN  A 301 (-3.0A)
None
None
None
 1.18A 3l2vA-5hsbA:
undetectable		 3l2vA-5hsbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifm NON-POU
DOMAIN-CONTAINING
OCTAMER-BINDING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 ASP A 228
GLN A 229
PRO A 226
GLU A 225
 None
 1.25A 3l2vA-5ifmA:
undetectable		 3l2vA-5ifmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ASP A 131
ASP A  95
GLN A  94
GLU A  63
 CA  A 503 ( 3.2A)
CA  A 503 (-3.1A)
None
CA  A 503 ( 2.3A)
 1.23A 3l2vA-5k8rA:
undetectable		 3l2vA-5k8rA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 ASP A  94
ASP A 136
TYR A 151
GLN A 153
 None
 1.07A 3l2vA-5karA:
undetectable		 3l2vA-5karA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A

(Homo sapiens) 		PF08210
(APOBEC_N) 		4 ASP A 163
GLN A 169
PRO A 172
GLN A 174
 None
 1.17A 3l2vA-5kegA:
undetectable		 3l2vA-5kegA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0q INTEGRASE

(Visna-maedi
virus) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ASP A  66
ASP A 118
GLN A 148
GLU A 154
 None
 1.15A 3l2vA-5m0qA:
17.6		 3l2vA-5m0qA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 4 ASP A  77
GLN A  30
PRO A  24
GLN A  23
 CA  A3001 (-3.2A)
None
None
None
 0.99A 3l2vA-5ms3A:
2.1		 3l2vA-5ms3A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myb ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		4 ASP A 587
GLN A 588
GLN A 610
GLU A 609
 None
 1.08A 3l2vA-5mybA:
undetectable		 3l2vA-5mybA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ASP A 721
ASP A 680
TYR A 626
GLN A 606
 None
 1.19A 3l2vA-5ngyA:
undetectable		 3l2vA-5ngyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2x GLYCOSIDE HYDROLASE
FAMILY 61

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 GLN A 172
PRO A 175
GLN A 176
GLU A 158
 SO4  A 319 (-3.3A)
None
None
None
 1.09A 3l2vA-5o2xA:
undetectable		 3l2vA-5o2xA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyl LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		no annotation 4 ASP D  69
ASP D  73
GLN D  81
GLU D  80
 CA  D 102 (-2.8A)
CA  D 102 (-3.1A)
None
CA  D 102 (-3.3A)
 1.16A 3l2vA-5oylD:
undetectable		 3l2vA-5oylD:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo sapiens) 		no annotation 4 ASP A 346
GLN A 352
PRO A 355
GLN A 357
 None
 1.05A 3l2vA-5sxgA:
undetectable		 3l2vA-5sxgA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6u CATHEPSIN K

(Mus musculus) 		PF00112
(Peptidase_C1) 		4 GLN A  76
TYR A 110
PRO A 213
GLN A  37
 None
 1.23A 3l2vA-5t6uA:
undetectable		 3l2vA-5t6uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA

(Human
immunodeficiency
virus 1;
Sulfolobus
solfataricus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ASP A  64
ASP A 116
TYR A 143
PRO A 145
GLN A 146
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
None
 0.83A 3l2vA-5u1cA:
12.1		 3l2vA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ASP A 250
TYR A  65
GLN A  61
GLU A 515
 None
 1.07A 3l2vA-5uuuA:
undetectable		 3l2vA-5uuuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6a ENDOGLUCANASE,
PUTATIVE

(Aspergillus
fumigatus) 		no annotation 4 GLN A 173
PRO A 176
GLN A 177
GLU A 159
 None
 1.10A 3l2vA-5x6aA:
undetectable		 3l2vA-5x6aA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P

(Kluyveromyces
lactis) 		no annotation 4 ASP A 226
GLN A 241
PRO A 221
GLN A 200
 None
 1.11A 3l2vA-5y5aA:
undetectable		 3l2vA-5y5aA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgb CADHERIN-11,
CADHERIN-6 CHIMERA

(Mus musculus) 		no annotation 4 ASP A 134
ASP A  98
GLN A  97
GLU A  66
 CA  A 303 ( 3.3A)
CA  A 301 (-3.2A)
None
CA  A 301 ( 2.3A)
 1.08A 3l2vA-6cgbA:
undetectable		 3l2vA-6cgbA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgs CADHERIN-7

(Mus musculus) 		no annotation 4 ASP A 134
ASP A  98
GLN A  97
GLU A  66
 CA  A 302 ( 3.3A)
CA  A 302 (-3.0A)
None
CA  A 302 ( 2.3A)
 1.17A 3l2vA-6cgsA:
undetectable		 3l2vA-6cgsA:
10.96