SIMILAR PATTERNS OF AMINO ACIDS FOR 3KWA_A_SPMA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 GLN A  92
HIS A  94
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
None
 0.45A 3kwaA-1jd0A:
36.1		 3kwaA-1jd0A:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
None
 1.36A 3kwaA-1jd0A:
36.1		 3kwaA-1jd0A:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		10 GLN A  90
HIS A  92
HIS A 111
VAL A 113
VAL A 123
LEU A 176
THR A 177
THR A 178
PRO A 180
TRP A 187
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
None
 0.43A 3kwaA-1kopA:
29.1		 3kwaA-1kopA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 HIS A  92
HIS A 111
VAL A 123
LEU A 176
THR A 177
PRO A 179
TRP A 187
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
None
None
 1.43A 3kwaA-1kopA:
29.1		 3kwaA-1kopA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		5 VAL A 123
LEU A 176
THR A 177
THR A 178
PRO A 180
 None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 1.13A 3kwaA-1kopA:
29.1		 3kwaA-1kopA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE

(Streptomyces
venezuelae) 		PF16363
(GDP_Man_Dehyd) 		5 HIS A 124
VAL A 122
VAL A 173
LEU A 110
THR A 107
 None
 1.36A 3kwaA-1r66A:
undetectable		 3kwaA-1r66A:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  94
LEU A 198
THR A 199
THR A 200
 None
ZN  A 601 ( 3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 1.23A 3kwaA-1rj6A:
36.9		 3kwaA-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		10 GLN A  92
HIS A  94
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-4.8A)
None
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
None
 0.41A 3kwaA-1rj6A:
36.9		 3kwaA-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 119
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 601 ( 3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
None
 1.41A 3kwaA-1rj6A:
36.9		 3kwaA-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
 AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.96A 3kwaA-1rj6A:
36.9		 3kwaA-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A 119
LEU A 198
THR A 199
THR A 200
 None
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
 1.23A 3kwaA-1urtA:
36.4		 3kwaA-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		10 GLN A  92
HIS A  94
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
None
ZN  A 280 ( 4.9A)
None
None
None
 0.46A 3kwaA-1urtA:
36.4		 3kwaA-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 119
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
None
 1.30A 3kwaA-1urtA:
36.4		 3kwaA-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
VAL A 121
LEU A 198
THR A 200
PRO A 202
 ZN  A 280 (-3.2A)
None
None
None
None
 1.18A 3kwaA-1urtA:
36.4		 3kwaA-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
None
ZN  A 280 ( 4.9A)
None
None
 0.92A 3kwaA-1urtA:
36.4		 3kwaA-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		9 GLN A 113
HIS A 115
HIS A 135
VAL A 137
VAL A 153
LEU A 216
THR A 217
THR A 218
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 ( 4.7A)
None
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.30A 3kwaA-1y7wA:
26.1		 3kwaA-1y7wA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		6 HIS A 115
HIS A 135
LEU A 216
THR A 217
PRO A 219
TRP A 227
 ZN  A 283 ( 3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
None
None
 1.44A 3kwaA-1y7wA:
26.1		 3kwaA-1y7wA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 VAL A 456
PHE A 292
LEU A 482
THR A 479
THR A 478
 None
None
None
FAD  A 750 (-3.1A)
FAD  A 750 (-3.4A)
 0.95A 3kwaA-2bf4A:
undetectable		 3kwaA-2bf4A:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.60A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 119
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 1.40A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.05A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 119
VAL A 143
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.34A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 VAL A 129
VAL A 153
LEU A 289
THR A 290
PRO A 286
 None
 1.07A 3kwaA-2xmrA:
undetectable		 3kwaA-2xmrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H

(Homo sapiens) 		PF00179
(UQ_con) 		5 HIS A  42
VAL A  44
VAL A  55
LEU A 120
THR A 121
 None
 1.25A 3kwaA-2z5dA:
undetectable		 3kwaA-2z5dA:
25.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
None
None
ZN  A   1 ( 4.7A)
None
None
 0.34A 3kwaA-2zncA:
31.5		 3kwaA-2zncA:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 119
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 4.7A)
None
None
 1.40A 3kwaA-2zncA:
31.5		 3kwaA-2zncA:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 GLN A 115
HIS A 163
HIS A 182
THR A 260
THR A 261
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.1A)
ZN  A 378 ( 4.5A)
None
 1.07A 3kwaA-3b1bA:
25.2		 3kwaA-3b1bA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		10 GLN A 161
HIS A 163
HIS A 182
VAL A 184
VAL A 201
LEU A 259
THR A 260
THR A 261
PRO A 263
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.1A)
None
None
None
ZN  A 378 ( 4.5A)
None
None
None
 0.40A 3kwaA-3b1bA:
25.2		 3kwaA-3b1bA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 163
HIS A 182
LEU A 259
THR A 260
PRO A 262
TRP A 270
 ZN  A 378 (-3.2A)
ZN  A 378 (-3.1A)
None
ZN  A 378 ( 4.5A)
None
None
 1.41A 3kwaA-3b1bA:
25.2		 3kwaA-3b1bA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  93
HIS A  95
PHE A 132
LEU A 199
PRO A 203
 4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 ( 4.9A)
 1.03A 3kwaA-3da2A:
41.7		 3kwaA-3da2A:
60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 HIS A  95
HIS A 120
VAL A 122
PHE A 132
VAL A 144
LEU A 199
THR A 200
PRO A 203
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 0.49A 3kwaA-3da2A:
41.7		 3kwaA-3da2A:
60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  95
HIS A 120
VAL A 144
LEU A 199
THR A 200
PRO A 202
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
None
 1.49A 3kwaA-3da2A:
41.7		 3kwaA-3da2A:
60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  95
VAL A 144
LEU A 199
THR A 200
PRO A 203
 ZN  A 301 ( 3.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
 1.31A 3kwaA-3da2A:
41.7		 3kwaA-3da2A:
60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  97
HIS A 120
LEU A 199
THR A 200
PRO A 203
TRP A 210
 ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 1.42A 3kwaA-3da2A:
41.7		 3kwaA-3da2A:
60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A 109
HIS A 111
HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
 None
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
None
None
 0.77A 3kwaA-3fe4A:
30.6		 3kwaA-3fe4A:
34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
PRO A 223
TRP A 230
 MG  A 901 (-3.2A)
None
None
None
None
None
None
 0.77A 3kwaA-3fe4A:
30.6		 3kwaA-3fe4A:
34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A 219
THR A 220
THR A 221
PRO A 223
TRP A 230
 None
 0.58A 3kwaA-3fe4A:
30.6		 3kwaA-3fe4A:
34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 GLN A  92
HIS A  94
HIS A 119
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
 0.35A 3kwaA-3ml5A:
42.6		 3kwaA-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
VAL A 121
PHE A 131
LEU A 198
THR A 199
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
 1.32A 3kwaA-3ml5A:
42.6		 3kwaA-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
None
 1.34A 3kwaA-3ml5A:
42.6		 3kwaA-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
 1.46A 3kwaA-3ml5A:
42.6		 3kwaA-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
 AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 0.87A 3kwaA-3ml5A:
42.6		 3kwaA-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 GLN A 102
HIS A 123
HIS A 142
THR A 215
THR A 216
 None
ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
 1.15A 3kwaA-3q31A:
24.3		 3kwaA-3q31A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		10 GLN A 121
HIS A 123
HIS A 142
VAL A 144
VAL A 154
LEU A 214
THR A 215
THR A 216
PRO A 218
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
None
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
None
MLT  A   3 (-4.9A)
 0.44A 3kwaA-3q31A:
24.3		 3kwaA-3q31A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		7 HIS A 123
HIS A 142
VAL A 154
LEU A 214
THR A 215
PRO A 217
TRP A 225
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
None
MLT  A   3 (-4.9A)
 1.34A 3kwaA-3q31A:
24.3		 3kwaA-3q31A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 GLN A  92
HIS A  94
HIS A 119
VAL A 121
PHE A 130
VAL A 142
THR A 198
THR A 199
PRO A 201
TRP A 208
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
None
None
ZN  A 261 ( 4.4A)
None
None
None
 0.48A 3kwaA-3uyqA:
40.3		 3kwaA-3uyqA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  92
HIS A  94
VAL A 121
PHE A 130
THR A 199
 None
ZN  A 261 (-3.3A)
None
None
None
 1.10A 3kwaA-3uyqA:
40.3		 3kwaA-3uyqA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
THR A 198
PRO A 200
TRP A 208
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
ZN  A 261 ( 4.4A)
None
None
 1.33A 3kwaA-3uyqA:
40.3		 3kwaA-3uyqA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		10 GLN A  87
HIS A  89
HIS A 108
VAL A 110
VAL A 120
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-4.7A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
None
 0.43A 3kwaA-4g7aA:
29.4		 3kwaA-4g7aA:
34.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 HIS A  89
HIS A 108
VAL A 120
LEU A 173
THR A 174
PRO A 176
TRP A 184
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
None
 1.38A 3kwaA-4g7aA:
29.4		 3kwaA-4g7aA:
34.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 VAL A 120
LEU A 173
THR A 174
THR A 175
PRO A 177
 AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 0.99A 3kwaA-4g7aA:
29.4		 3kwaA-4g7aA:
34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n40 PROTEIN ECT2

(Homo sapiens) 		PF00533
(BRCT)
PF12738
(PTCB-BRCT) 		5 HIS A 279
VAL A 281
PHE A 250
VAL A 301
THR A 262
 None
 1.34A 3kwaA-4n40A:
undetectable		 3kwaA-4n40A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n40 PROTEIN ECT2

(Homo sapiens) 		PF00533
(BRCT)
PF12738
(PTCB-BRCT) 		5 HIS A 279
VAL A 281
PHE A 250
VAL A 301
TRP A 305
 None
 1.36A 3kwaA-4n40A:
undetectable		 3kwaA-4n40A:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 GLN A  92
HIS A  94
HIS A 119
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
None
None
ZN  A 301 ( 4.4A)
None
None
None
 0.23A 3kwaA-4qk3A:
43.3		 3kwaA-4qk3A:
95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
VAL A 121
PHE A 131
LEU A 198
THR A 199
 None
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
 1.33A 3kwaA-4qk3A:
43.3		 3kwaA-4qk3A:
95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
None
None
 1.41A 3kwaA-4qk3A:
43.3		 3kwaA-4qk3A:
95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
None
 1.47A 3kwaA-4qk3A:
43.3		 3kwaA-4qk3A:
95.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		5 VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.34A 3kwaA-4twlA:
28.3		 3kwaA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umz CYTOCHROME P450
HYDROXYLASE PIKC

(Streptomyces
venezuelae) 		PF00067
(p450) 		5 HIS A  42
VAL A  55
PHE A  70
LEU A 304
THR A 307
 None
 1.21A 3kwaA-4umzA:
undetectable		 3kwaA-4umzA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		10 GLN A 110
HIS A 112
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.49A 3kwaA-4uovA:
30.9		 3kwaA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
HIS A 131
VAL A 143
THR A 198
PRO A 200
TRP A 208
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.3A)
None
None
 1.30A 3kwaA-4uovA:
30.9		 3kwaA-4uovA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		10 GLN A  87
HIS A  89
HIS A 108
VAL A 110
VAL A 120
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
None
 0.42A 3kwaA-4x5sA:
29.6		 3kwaA-4x5sA:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A 108
VAL A 120
THR A 174
PRO A 176
TRP A 184
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.3A)
None
None
 1.24A 3kwaA-4x5sA:
29.6		 3kwaA-4x5sA:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
VAL A 120
LEU A 173
THR A 174
THR A 175
PRO A 177
 ZN  A 301 ( 3.1A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 1.09A 3kwaA-4x5sA:
29.6		 3kwaA-4x5sA:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		8 HIS A 110
HIS A 129
VAL A 131
VAL A 141
LEU A 190
THR A 191
PRO A 194
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 ( 3.1A)
None
None
None
ZN  A 301 (-4.3A)
None
None
 0.51A 3kwaA-4xfwA:
26.4		 3kwaA-4xfwA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		7 HIS A 110
VAL A 131
VAL A 141
LEU A 190
THR A 191
PRO A 193
TRP A 201
 ZN  A 301 (-3.3A)
None
None
None
ZN  A 301 (-4.3A)
None
None
 1.35A 3kwaA-4xfwA:
26.4		 3kwaA-4xfwA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
HIS A 129
LEU A 190
THR A 191
PRO A 194
TRP A 201
 ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
ZN  A 301 (-4.3A)
None
None
 1.49A 3kwaA-4xfwA:
26.4		 3kwaA-4xfwA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		10 GLN A 158
HIS A 160
HIS A 179
VAL A 181
VAL A 192
LEU A 253
THR A 254
THR A 255
PRO A 257
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
None
 0.49A 3kwaA-4xixA:
25.6		 3kwaA-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 GLN A 158
HIS A 160
VAL A 181
LEU A 253
THR A 255
 None
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-3.6A)
 1.32A 3kwaA-4xixA:
25.6		 3kwaA-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 HIS A 160
HIS A 179
VAL A 192
LEU A 253
THR A 254
PRO A 256
TRP A 264
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
None
None
 1.38A 3kwaA-4xixA:
25.6		 3kwaA-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 HIS A 162
HIS A 179
LEU A 253
THR A 254
THR A 255
PRO A 257
TRP A 264
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
None
 1.45A 3kwaA-4xixA:
25.6		 3kwaA-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 VAL A 192
LEU A 253
THR A 254
THR A 255
PRO A 257
 None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 1.15A 3kwaA-4xixA:
25.6		 3kwaA-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		10 GLN A 163
HIS A 165
HIS A 184
VAL A 186
VAL A 196
LEU A 251
THR A 252
THR A 253
PRO A 255
TRP A 262
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
None
 0.40A 3kwaA-4xz5A:
29.3		 3kwaA-4xz5A:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 165
HIS A 184
LEU A 251
THR A 252
PRO A 254
TRP A 262
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
None
 1.38A 3kwaA-4xz5A:
29.3		 3kwaA-4xz5A:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 184
VAL A 196
LEU A 251
THR A 252
THR A 253
PRO A 255
 ZN  A 401 ( 3.1A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.13A 3kwaA-4xz5A:
29.3		 3kwaA-4xz5A:
32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1h CYSTATHIONINE
BETA-SYNTHASE

(Lactobacillus
plantarum) 		PF00291
(PALP) 		5 GLN A 236
VAL A 198
VAL A 172
LEU A 278
PRO A 279
 None
None
None
None
GOL  A 408 ( 4.4A)
 1.08A 3kwaA-5b1hA:
undetectable		 3kwaA-5b1hA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 GLN A  92
HIS A  94
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
None
 0.40A 3kwaA-5cjfA:
36.3		 3kwaA-5cjfA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 119
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
None
 1.38A 3kwaA-5cjfA:
36.3		 3kwaA-5cjfA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
VAL A 121
LEU A 198
THR A 200
PRO A 202
 ZN  A 301 (-3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
None
 1.20A 3kwaA-5cjfA:
36.3		 3kwaA-5cjfA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 1.49A 3kwaA-5cjfA:
36.3		 3kwaA-5cjfA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 LEU A 256
THR A 257
THR A 258
PRO A 260
TRP A 267
 None
 0.30A 3kwaA-5e5uA:
33.9		 3kwaA-5e5uA:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 PHE A 187
LEU A 256
THR A 257
THR A 258
TRP A 267
 None
 0.74A 3kwaA-5e5uA:
33.9		 3kwaA-5e5uA:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		11 GLN X  91
HIS X  93
HIS X 118
VAL X 120
PHE X 129
VAL X 141
LEU X 196
THR X 197
THR X 198
PRO X 200
TRP X 207
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
None
None
None
ZN  X 301 ( 4.4A)
None
None
None
 0.25A 3kwaA-5eztX:
43.6		 3kwaA-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 GLN X  91
HIS X  93
VAL X 120
PHE X 129
LEU X 196
THR X 198
 None
ZN  X 301 (-3.2A)
None
None
None
None
 1.36A 3kwaA-5eztX:
43.6		 3kwaA-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 HIS X  93
HIS X 118
VAL X 141
LEU X 196
THR X 197
PRO X 199
TRP X 207
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
None
ZN  X 301 ( 4.4A)
None
None
 1.41A 3kwaA-5eztX:
43.6		 3kwaA-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 HIS X  95
HIS X 118
LEU X 196
THR X 197
THR X 198
PRO X 200
TRP X 207
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
ZN  X 301 ( 4.4A)
None
None
None
 1.47A 3kwaA-5eztX:
43.6		 3kwaA-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 VAL X 141
LEU X 196
THR X 197
THR X 198
PRO X 200
 None
None
ZN  X 301 ( 4.4A)
None
None
 0.92A 3kwaA-5eztX:
43.6		 3kwaA-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		10 GLN A  94
HIS A  96
HIS A 115
VAL A 117
VAL A 127
LEU A 181
THR A 182
THR A 183
PRO A 185
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
None
 0.38A 3kwaA-5hpjA:
29.1		 3kwaA-5hpjA:
35.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 HIS A  96
HIS A 115
VAL A 127
LEU A 181
THR A 182
PRO A 184
TRP A 192
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
None
None
 1.38A 3kwaA-5hpjA:
29.1		 3kwaA-5hpjA:
35.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 HIS A  98
HIS A 115
LEU A 181
THR A 182
THR A 183
PRO A 185
TRP A 192
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
None
 1.49A 3kwaA-5hpjA:
29.1		 3kwaA-5hpjA:
35.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM

(Salmonella
enterica) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 HIS A 491
PHE A 394
VAL A 494
THR A 448
THR A 266
 None
 1.03A 3kwaA-5i5dA:
undetectable		 3kwaA-5i5dA:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.36A 3kwaA-5jn9A:
32.8		 3kwaA-5jn9A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 119
VAL A 143
THR A 199
PRO A 201
TRP A 209
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.4A)
None
None
 1.30A 3kwaA-5jn9A:
32.8		 3kwaA-5jn9A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
 1.13A 3kwaA-5jn9A:
32.8		 3kwaA-5jn9A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 10 GLN A 115
HIS A 117
HIS A 136
VAL A 138
VAL A 148
LEU A 201
THR A 202
THR A 203
PRO A 205
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 (-4.4A)
None
None
None
 0.34A 3kwaA-6ekiA:
29.8		 3kwaA-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 7 HIS A 117
HIS A 136
VAL A 148
LEU A 201
THR A 202
PRO A 204
TRP A 212
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 (-4.4A)
None
None
 1.36A 3kwaA-6ekiA:
29.8		 3kwaA-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 7 HIS A 119
HIS A 136
LEU A 201
THR A 202
THR A 203
PRO A 205
TRP A 212
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-4.4A)
None
None
None
 1.44A 3kwaA-6ekiA:
29.8		 3kwaA-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 10 GLN A  92
HIS A  94
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
None
 0.46A 3kwaA-6fe1A:
33.3		 3kwaA-6fe1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 7 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
None
 1.32A 3kwaA-6fe1A:
33.3		 3kwaA-6fe1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 0.85A 3kwaA-6fe1A:
33.3		 3kwaA-6fe1A:
14.90