SIMILAR PATTERNS OF AMINO ACIDS FOR 3KW2_B_ADNB300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bea BIFUNCTIONAL
AMYLASE/SERINE
PROTEASE INHIBITOR

(Zea mays) 		PF00234
(Tryp_alpha_amyl) 		5 ILE A  12
LEU A  17
LEU A  60
THR A  58
ALA A  59
 None
 1.21A 3kw2B-1beaA:
undetectable		 3kw2B-1beaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chm CREATINE
AMIDINOHYDROLASE

(Pseudomonas
putida) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ALA A  42
VAL A  70
ILE A 121
GLY A 122
LEU A 115
 None
 1.17A 3kw2B-1chmA:
undetectable		 3kw2B-1chmA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		5 ILE A 114
GLY A 116
SER A  92
LEU A  93
ALA A 124
 None
NAP  A 191 ( 4.2A)
None
None
None
 1.07A 3kw2B-1dr6A:
2.2		 3kw2B-1dr6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0k DNA HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C) 		5 ALA A 326
VAL A 420
GLY A 330
LEU A 339
THR A 390
 None
 1.24A 3kw2B-1e0kA:
undetectable		 3kw2B-1e0kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 ALA A  66
ILE A  71
GLY A  70
LEU A  87
ALA A  80
 None
 1.08A 3kw2B-1jihA:
undetectable		 3kw2B-1jihA:
16.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 ILE A 194
GLY A 195
LEU A 223
THR A 225
ALA A 228
 None
 0.42A 3kw2B-1nxzA:
24.2		 3kw2B-1nxzA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		5 ILE A1156
LEU A1168
LEU A1494
THR A1492
ALA A1493
 None
 1.19A 3kw2B-1qhmA:
undetectable		 3kw2B-1qhmA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0d HUNTINGTIN
INTERACTING PROTEIN
12

(Homo sapiens) 		PF01608
(I_LWEQ) 		5 ALA A 890
ILE A 801
LEU A 886
LEU A 830
THR A 828
 None
 1.07A 3kw2B-1r0dA:
undetectable		 3kw2B-1r0dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 143
ILE A 146
SER A 139
LEU A 138
ALA A 299
 None
 1.24A 3kw2B-1rjwA:
2.3		 3kw2B-1rjwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 660
VAL A 656
ILE A 557
LEU A 576
ALA A 583
 None
 1.14A 3kw2B-1tkcA:
undetectable		 3kw2B-1tkcA:
16.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 ALA A 173
GLY A 204
LEU A 227
LEU A 232
ALA A 237
 None
 0.63A 3kw2B-1vhkA:
18.6		 3kw2B-1vhkA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 ALA A 173
GLY A 204
LEU A 232
THR A 234
ALA A 237
 None
 0.58A 3kw2B-1vhkA:
18.6		 3kw2B-1vhkA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 416
LEU A 469
LEU A 472
THR A 501
ALA A 504
 None
 0.88A 3kw2B-1w27A:
undetectable		 3kw2B-1w27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 223
VAL A 196
ILE A 248
GLY A 250
SER A 194
 None
 1.01A 3kw2B-1wwkA:
3.0		 3kw2B-1wwkA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 ALA A 346
GLY A 341
SER A 236
LEU A 235
LEU A 258
 None
 1.21A 3kw2B-1wytA:
undetectable		 3kw2B-1wytA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		5 ALA A  61
ILE A 140
GLY A 117
LEU A 208
LEU A 159
 None
 0.98A 3kw2B-2fukA:
undetectable		 3kw2B-2fukA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 335
ILE A 334
GLY A 333
SER A 337
LEU A 326
 None
 1.22A 3kw2B-2fymA:
undetectable		 3kw2B-2fymA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ALA A 137
VAL A 145
GLY A 125
THR A 236
ALA A 239
 None
 0.92A 3kw2B-2ivpA:
undetectable		 3kw2B-2ivpA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sinapis alba) 		PF00348
(polyprenyl_synt) 		5 VAL A  81
ILE A 207
GLY A 204
LEU A 133
ALA A 149
 None
 1.20A 3kw2B-2j1oA:
undetectable		 3kw2B-2j1oA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaj NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		5 ALA A  63
ILE A  60
SER A  13
LEU A  12
THR A  59
 None
 1.19A 3kw2B-2vajA:
undetectable		 3kw2B-2vajA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 ALA A 310
ILE A 320
LEU A 312
LEU A 344
ALA A 333
 None
 1.04A 3kw2B-2zuxA:
undetectable		 3kw2B-2zuxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 5 ALA A2189
VAL A2201
LEU A2251
LEU A2255
THR A2257
 None
 1.10A 3kw2B-3dyjA:
undetectable		 3kw2B-3dyjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 ILE A 158
GLY A 159
LEU A  35
THR A 196
ALA A 199
 None
 0.79A 3kw2B-3e7dA:
undetectable		 3kw2B-3e7dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 ALA A 566
ILE A 505
GLY A 503
LEU A 527
LEU A 530
 None
 1.21A 3kw2B-3ifqA:
undetectable		 3kw2B-3ifqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		5 ALA A 731
ILE A 707
LEU A 721
LEU A 718
ALA A 717
 None
 1.25A 3kw2B-3ihpA:
undetectable		 3kw2B-3ihpA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		5 ALA A 201
ILE A 200
GLY A 199
SER A 184
LEU A 185
 None
 1.11A 3kw2B-3lrkA:
undetectable		 3kw2B-3lrkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.19A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.24A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.22A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.18A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltm ALPHA-REP4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.24A 3kw2B-3ltmA:
undetectable		 3kw2B-3ltmA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 ILE A 283
GLY A 282
LEU A 306
LEU A 310
ALA A 309
 None
 1.20A 3kw2B-3m1rA:
2.5		 3kw2B-3m1rA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myd FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Helicobacter
pylori) 		PF00771
(FHIPEP) 		5 ALA A 569
VAL A 573
ILE A 565
THR A 595
ALA A 598
 None
 0.76A 3kw2B-3mydA:
undetectable		 3kw2B-3mydA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		5 ALA A 184
ILE A 161
GLY A 186
LEU A  11
THR A  46
 None
 1.13A 3kw2B-3oz7A:
3.0		 3kw2B-3oz7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		5 ILE A 357
ASP A 316
LEU A 385
LEU A 323
ALA A 328
 None
 1.08A 3kw2B-3pgyA:
undetectable		 3kw2B-3pgyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		5 ILE A 357
GLY A 356
ASP A 316
LEU A 385
ALA A 328
 None
 1.17A 3kw2B-3pgyA:
undetectable		 3kw2B-3pgyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 285
ARG A 286
ILE A 357
LEU A 305
LEU A 278
 None
 1.04A 3kw2B-3r7kA:
undetectable		 3kw2B-3r7kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 ILE A 315
SER A 285
LEU A 288
THR A 299
ALA A 292
 None
 1.18A 3kw2B-3vomA:
undetectable		 3kw2B-3vomA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ALA A  90
ILE A  94
LEU A 110
LEU A 107
ALA A 106
 None
 1.28A 3kw2B-3w1gA:
undetectable		 3kw2B-3w1gA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		5 ALA A 270
ILE A 300
GLY A 301
LEU A 320
ALA A 273
 None
 0.84A 3kw2B-3zidA:
2.9		 3kw2B-3zidA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4

(Homo sapiens) 		PF00023
(Ank) 		5 ALA A 377
ILE A 385
GLY A 384
THR A 339
ALA A 332
 None
 1.19A 3kw2B-4dx2A:
undetectable		 3kw2B-4dx2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ILE A 492
GLY A 423
LEU A 466
THR A 421
ALA A 419
 None
 1.12A 3kw2B-4ga6A:
2.8		 3kw2B-4ga6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 ALA A  53
VAL A  55
ILE A   7
GLY A   8
THR A 137
 None
 1.12A 3kw2B-4gm6A:
2.4		 3kw2B-4gm6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 ILE A 530
GLY A 485
SER A 463
LEU A 464
ALA A 536
 None
 1.25A 3kw2B-4h1gA:
undetectable		 3kw2B-4h1gA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ALA A 223
ILE A 228
GLY A 227
LEU A 254
LEU A 258
 None
 1.20A 3kw2B-4iuwA:
undetectable		 3kw2B-4iuwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ALA A 223
ILE A 228
GLY A 227
SER A 255
LEU A 254
 None
 1.25A 3kw2B-4iuwA:
undetectable		 3kw2B-4iuwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		5 ILE A 395
GLY A 396
LEU A 433
THR A 542
ALA A 530
 None
 1.24A 3kw2B-4jdzA:
undetectable		 3kw2B-4jdzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 ILE A 160
GLY A 161
LEU A 198
THR A 307
ALA A 295
 None
 1.25A 3kw2B-4je0A:
undetectable		 3kw2B-4je0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw2 A3 ARTIFICIAL
PROTEIN

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A  68
ILE A  72
GLY A  42
LEU A  50
ALA A  46
 None
 1.18A 3kw2B-4jw2A:
undetectable		 3kw2B-4jw2A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36)
PF07504
(FTP) 		5 ALA A 362
GLY B  93
ASP B  94
LEU A 439
ALA A 572
 None
 1.23A 3kw2B-4k90A:
undetectable		 3kw2B-4k90A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		5 ALA A  61
ARG A  62
ILE A  71
LEU A  18
ALA A  34
 None
 1.26A 3kw2B-4ns4A:
undetectable		 3kw2B-4ns4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 VAL A 245
ILE A 279
GLY A 280
THR A 174
ALA A 268
 None
 0.95A 3kw2B-4p52A:
undetectable		 3kw2B-4p52A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Arthrobacter
sp. FB24) 		PF13377
(Peripla_BP_3) 		5 ILE A 279
GLY A 280
ASP A 255
LEU A 335
ALA A 174
 None
 1.19A 3kw2B-4rkrA:
2.6		 3kw2B-4rkrA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A

(Lachancea
kluyveri) 		no annotation 5 ILE a 465
LEU a 448
LEU a 451
THR a 453
ALA a 452
 None
 1.11A 3kw2B-4uera:
undetectable		 3kw2B-4uera:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 ALA A 119
ILE A  97
LEU A 115
LEU A  87
ALA A  86
 None
 1.01A 3kw2B-4v15A:
undetectable		 3kw2B-4v15A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 ARG A  95
ILE A  78
GLY A  77
LEU A  68
ALA A  67
 None
 1.17A 3kw2B-4v15A:
undetectable		 3kw2B-4v15A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 ILE A 356
GLY A 355
ASP A 316
LEU A 384
ALA A 327
 None
 1.20A 3kw2B-4wxbA:
undetectable		 3kw2B-4wxbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		5 SER A 167
LEU A 166
LEU A 319
THR A 173
ALA A 172
 None
 1.12A 3kw2B-4x8iA:
undetectable		 3kw2B-4x8iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A 408
ARG A 407
ILE A 350
LEU A 284
LEU A 416
 None
None
ACT  A 504 ( 4.7A)
None
None
 1.12A 3kw2B-4xeaA:
undetectable		 3kw2B-4xeaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ALA C  99
ILE C 103
GLY C  73
LEU C  81
ALA C  77
 None
 1.17A 3kw2B-4xl5C:
undetectable		 3kw2B-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ALA C 192
ILE C 196
GLY C 166
LEU C 174
ALA C 170
 None
 1.24A 3kw2B-4xl5C:
undetectable		 3kw2B-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ALA C 223
ILE C 227
GLY C 197
LEU C 205
ALA C 201
 None
 1.26A 3kw2B-4xl5C:
undetectable		 3kw2B-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG

(Haemophilus
influenzae) 		PF03595
(SLAC1) 		5 ALA A  84
ILE A  88
SER A  81
LEU A 144
ALA A 148
 None
 1.05A 3kw2B-4ycrA:
undetectable		 3kw2B-4ycrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yte H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ0715

(Methanocaldococcus
jannaschii) 		no annotation 5 ALA A   8
GLY A  31
SER A  49
LEU A  48
ALA A  36
 None
 1.13A 3kw2B-4yteA:
2.2		 3kw2B-4yteA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  71
ILE H  51
GLY H  52
LEU H  86
LEU H  23
 None
 0.86A 3kw2B-4yueH:
undetectable		 3kw2B-4yueH:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B

(Methylobacterium
extorquens) 		PF12706
(Lactamase_B_2) 		5 ALA A 191
ARG A 189
ILE A 193
GLY A 180
LEU A 213
 None
 1.26A 3kw2B-4z7rA:
undetectable		 3kw2B-4z7rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ILE A 506
GLY A 503
SER A 105
LEU A 106
ALA A 568
 None
 1.15A 3kw2B-4zajA:
undetectable		 3kw2B-4zajA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A 192
ILE A 196
GLY A 166
LEU A 174
ALA A 170
 None
 1.28A 3kw2B-4zv6A:
undetectable		 3kw2B-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A 223
ILE A 227
GLY A 197
LEU A 205
ALA A 201
 None
 1.24A 3kw2B-4zv6A:
undetectable		 3kw2B-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A 254
ILE A 258
GLY A 228
LEU A 236
ALA A 232
 None
 1.24A 3kw2B-4zv6A:
undetectable		 3kw2B-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1252
ILE A1206
GLY A1207
LEU A1603
ALA A1605
 None
 1.20A 3kw2B-5a31A:
undetectable		 3kw2B-5a31A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE
PINS

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		5 ALA B  82
ILE B  83
SER L 333
LEU B  48
ALA B  47
 None
 1.26A 3kw2B-5a7dB:
undetectable		 3kw2B-5a7dB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq ARTIFICIAL REPEAT
PROTEINS (ALPHAREP3)

(synthetic
construct) 		PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A  67
ILE A  71
GLY A  41
LEU A  49
ALA A  45
 None
 1.21A 3kw2B-5dcqA:
undetectable		 3kw2B-5dcqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq ARTIFICIAL REPEAT
PROTEINS (ALPHAREP3)

(synthetic
construct) 		PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A  98
ILE A 102
GLY A  72
LEU A  80
ALA A  76
 None
 1.23A 3kw2B-5dcqA:
undetectable		 3kw2B-5dcqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2c XAA-PRO DIPEPTIDASE

(Mycobacterium
tuberculosis) 		PF01321
(Creatinase_N) 		5 ALA A  87
ARG A  86
GLY A  91
LEU A  44
ALA A  21
 None
 1.16A 3kw2B-5e2cA:
undetectable		 3kw2B-5e2cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ALA A 393
ILE A 398
GLY A 397
LEU A 123
LEU A 184
 None
 1.04A 3kw2B-5egeA:
undetectable		 3kw2B-5egeA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 ALA A 150
ILE A 104
GLY A 105
THR A 103
ALA A  97
 None
 1.07A 3kw2B-5hosA:
undetectable		 3kw2B-5hosA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 657
ILE A 554
LEU A 573
LEU A 570
ALA A 580
 None
 1.10A 3kw2B-5i51A:
undetectable		 3kw2B-5i51A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C)
PF13155
(Toprim_2) 		5 ALA D 326
VAL D 420
GLY D 330
LEU D 339
THR D 390
 None
 1.20A 3kw2B-5iknD:
undetectable		 3kw2B-5iknD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		5 ARG A 292
GLY A  19
LEU A  34
THR A  23
ALA A  24
 ADP  A 402 (-4.3A)
ADP  A 402 (-3.1A)
None
None
None
 1.05A 3kw2B-5jygA:
undetectable		 3kw2B-5jygA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 365
GLY A 361
LEU A 388
LEU A 406
ALA A 405
 None
 1.28A 3kw2B-5ks8A:
undetectable		 3kw2B-5ks8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 VAL A  53
ILE A 160
GLY A 161
THR A 197
ALA A 200
 None
 0.73A 3kw2B-5n0gA:
undetectable		 3kw2B-5n0gA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 ALA A 191
ILE A 197
GLY A 196
LEU A 224
ALA A 223
 None
 1.22A 3kw2B-5nl7A:
undetectable		 3kw2B-5nl7A:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 ILE A 195
GLY A 196
LEU A 224
THR A 226
ALA A 229
 None
SAM  A 501 (-4.1A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
 0.25A 3kw2B-5o96A:
26.0		 3kw2B-5o96A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 VAL A 301
ILE A 184
ASP A 299
LEU A 550
ALA A 548
 None
 1.17A 3kw2B-5opqA:
undetectable		 3kw2B-5opqA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ILE A  17
GLY A  14
SER A 124
LEU A 135
ALA A 130
 None
None
7VD  A 302 (-2.7A)
None
None
 1.07A 3kw2B-5u5gA:
3.2		 3kw2B-5u5gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uah RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		5 ALA F 431
ILE F 435
GLY F 411
SER F 428
LEU F 386
 None
 1.15A 3kw2B-5uahF:
undetectable		 3kw2B-5uahF:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ALA A 240
ARG A 244
ILE A 236
LEU A 262
ALA A 264
 None
 1.28A 3kw2B-5ujuA:
3.4		 3kw2B-5ujuA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		5 ALA A  81
ILE A  74
LEU A  37
LEU A  36
ALA A  33
 None
 1.21A 3kw2B-5visA:
undetectable		 3kw2B-5visA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk1 CAPSID STABILIZING
PROTEIN

(Pseudoalteromonas
phage TW1) 		no annotation 5 ALA X  82
ILE X  42
GLY X  22
SER X  84
LEU X  57
 None
 1.07A 3kw2B-5wk1X:
undetectable		 3kw2B-5wk1X:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4t PHOTOACTIVATED
ADENYLYL CYCLASE

(Cyanobacteria) 		PF00211
(Guanylate_cyc)
PF04940
(BLUF) 		5 VAL A 350
ILE A 343
GLY A 344
SER A 236
THR A 162
 None
 1.03A 3kw2B-5x4tA:
undetectable		 3kw2B-5x4tA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 ALA A 324
GLY A 320
LEU A 317
THR A 402
ALA A 405
 None
 0.91A 3kw2B-5ydjA:
undetectable		 3kw2B-5ydjA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yje PROTEIN HIRA

(Homo sapiens) 		no annotation 5 ALA A 789
ILE A 777
LEU A 757
THR A 740
ALA A 751
 None
 1.21A 3kw2B-5yjeA:
undetectable		 3kw2B-5yjeA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 ALA A 580
VAL A 576
ILE A 469
GLY A 468
LEU A 510
 None
 1.18A 3kw2B-6aunA:
undetectable		 3kw2B-6aunA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 527
ILE A 523
GLY A 524
LEU A 503
THR A 531
 None
 1.01A 3kw2B-6c26A:
undetectable		 3kw2B-6c26A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.24A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.25A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.15A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.19A 3kw2B-6ft5A:
undetectable		 3kw2B-6ft5A:
undetectable