SIMILAR PATTERNS OF AMINO ACIDS FOR 3KW2_A_ADNA300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0k DNA HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C) 		5 ALA A 326
VAL A 420
GLY A 330
LEU A 339
THR A 390
 None
 1.21A 3kw2A-1e0kA:
0.1		 3kw2A-1e0kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 333
ILE A 332
GLY A 331
SER A 335
LEU A 324
 None
 1.22A 3kw2A-1iyxA:
0.0		 3kw2A-1iyxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 ALA A  66
ILE A  71
GLY A  70
LEU A  87
ALA A  80
 None
 1.06A 3kw2A-1jihA:
0.0		 3kw2A-1jihA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpe DSBD-ALPHA

(Escherichia
coli) 		PF11412
(DsbC) 		5 ALA A  53
VAL A 122
ILE A  55
LEU A 119
THR A  86
 None
 0.87A 3kw2A-1jpeA:
0.2		 3kw2A-1jpeA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 ILE A 194
GLY A 195
LEU A 223
THR A 225
ALA A 228
 None
 0.47A 3kw2A-1nxzA:
24.5		 3kw2A-1nxzA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		5 ILE A1156
LEU A1168
LEU A1494
THR A1492
ALA A1493
 None
 1.18A 3kw2A-1qhmA:
0.8		 3kw2A-1qhmA:
15.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 ALA A 173
GLY A 204
LEU A 232
THR A 234
ALA A 237
 None
 0.61A 3kw2A-1vhkA:
24.7		 3kw2A-1vhkA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 416
LEU A 469
LEU A 472
THR A 501
ALA A 504
 None
 0.83A 3kw2A-1w27A:
0.0		 3kw2A-1w27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 419
GLY A 420
SER A 356
LEU A 360
ALA A 283
 None
 1.23A 3kw2A-1w27A:
0.0		 3kw2A-1w27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA B 318
VAL B 314
ILE B 204
LEU B 223
ALA B 230
 None
 1.05A 3kw2A-1w85B:
3.1		 3kw2A-1w85B:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwj CIRCADIAN CLOCK
PROTEIN KAIB

(Synechocystis
sp.) 		PF07689
(KaiB) 		5 ILE A  77
GLY A  78
ASP A  82
LEU A  90
ALA A  66
 None
 1.28A 3kw2A-1wwjA:
undetectable		 3kw2A-1wwjA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 ALA A 346
GLY A 341
SER A 236
LEU A 235
LEU A 258
 None
 1.22A 3kw2A-1wytA:
undetectable		 3kw2A-1wytA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 335
ILE A 334
GLY A 333
SER A 337
LEU A 326
 None
 1.22A 3kw2A-2fymA:
undetectable		 3kw2A-2fymA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 ALA A 310
ILE A 320
LEU A 312
LEU A 344
ALA A 333
 None
 1.05A 3kw2A-2zuxA:
undetectable		 3kw2A-2zuxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE

(Mycobacterium
gastri) 		PF00215
(OMPdecase) 		5 ALA A1185
ILE A1189
GLY A1187
LEU A1202
ALA A1198
 None
None
SO4  A6001 (-3.9A)
None
None
 1.19A 3kw2A-3ajxA:
4.3		 3kw2A-3ajxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2f FERREDOXIN-1,
CHLOROPLASTIC

(Zea mays) 		PF00111
(Fer2) 		5 VAL A  51
ILE A  24
SER A  55
THR A  76
ALA A  79
 None
 1.24A 3kw2A-3b2fA:
undetectable		 3kw2A-3b2fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A2133
ARG A2134
ILE A2141
LEU A2178
LEU A2126
 None
 1.21A 3kw2A-3cmuA:
undetectable		 3kw2A-3cmuA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A3133
ARG A3134
ILE A3141
LEU A3178
LEU A3126
 None
 1.20A 3kw2A-3cmuA:
undetectable		 3kw2A-3cmuA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A4133
ARG A4134
ILE A4141
LEU A4178
LEU A4126
 None
 1.20A 3kw2A-3cmuA:
undetectable		 3kw2A-3cmuA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A5133
ARG A5134
ILE A5141
LEU A5178
LEU A5126
 None
 1.21A 3kw2A-3cmuA:
undetectable		 3kw2A-3cmuA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 5 ALA A 272
ILE A 266
GLY A 267
SER A 274
LEU A 208
 None
 1.24A 3kw2A-3d0kA:
2.5		 3kw2A-3d0kA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyj TALIN-1

(Mus musculus) 		no annotation 5 ALA A2189
VAL A2201
LEU A2251
LEU A2255
THR A2257
 None
 1.10A 3kw2A-3dyjA:
undetectable		 3kw2A-3dyjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 ILE A 158
GLY A 159
LEU A  35
THR A 196
ALA A 199
 None
 0.85A 3kw2A-3e7dA:
undetectable		 3kw2A-3e7dA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ALA A 169
ARG A 170
ILE A 185
LEU A 466
LEU A 161
 None
 1.14A 3kw2A-3hhsA:
undetectable		 3kw2A-3hhsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 ALA A 566
ILE A 505
GLY A 503
LEU A 527
LEU A 530
 None
 1.15A 3kw2A-3ifqA:
undetectable		 3kw2A-3ifqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		5 ALA A 731
ILE A 707
LEU A 721
LEU A 718
ALA A 717
 None
 1.22A 3kw2A-3ihpA:
undetectable		 3kw2A-3ihpA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4i UNCHARACTERIZED
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF03737
(RraA-like) 		5 ALA A 122
ARG A 140
ILE A 118
GLY A 120
LEU A 135
 None
 1.11A 3kw2A-3k4iA:
undetectable		 3kw2A-3k4iA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 281
SER A 288
LEU A 287
LEU A 322
THR A 320
 None
 1.19A 3kw2A-3ldhA:
undetectable		 3kw2A-3ldhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		5 ALA A 201
ILE A 200
GLY A 199
SER A 184
LEU A 185
 None
 1.08A 3kw2A-3lrkA:
undetectable		 3kw2A-3lrkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.17A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.22A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.20A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.17A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltm ALPHA-REP4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.22A 3kw2A-3ltmA:
undetectable		 3kw2A-3ltmA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 ILE A 283
GLY A 282
LEU A 306
LEU A 310
ALA A 309
 None
 1.21A 3kw2A-3m1rA:
2.2		 3kw2A-3m1rA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myd FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Helicobacter
pylori) 		PF00771
(FHIPEP) 		5 ALA A 569
VAL A 573
ILE A 565
THR A 595
ALA A 598
 None
 0.79A 3kw2A-3mydA:
undetectable		 3kw2A-3mydA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		5 ALA A 184
ILE A 161
GLY A 186
LEU A  11
THR A  46
 None
 1.10A 3kw2A-3oz7A:
2.4		 3kw2A-3oz7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		5 ILE A 357
ASP A 316
LEU A 385
LEU A 323
ALA A 328
 None
 1.08A 3kw2A-3pgyA:
undetectable		 3kw2A-3pgyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		5 ILE A 357
GLY A 356
ASP A 316
LEU A 385
ALA A 328
 None
 1.14A 3kw2A-3pgyA:
undetectable		 3kw2A-3pgyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 308
ILE A 299
ASP A  95
LEU A 341
ALA A 337
 None
 1.13A 3kw2A-3t6cA:
undetectable		 3kw2A-3t6cA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 ILE A 315
SER A 285
LEU A 288
THR A 299
ALA A 292
 None
 1.17A 3kw2A-3vomA:
undetectable		 3kw2A-3vomA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 158
ILE A 140
SER A 170
LEU A 248
ALA A 147
 None
 1.28A 3kw2A-3vteA:
undetectable		 3kw2A-3vteA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ALA A  90
ILE A  94
LEU A 110
LEU A 107
ALA A 106
 None
 1.25A 3kw2A-3w1gA:
undetectable		 3kw2A-3w1gA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4

(Homo sapiens) 		PF00023
(Ank) 		5 ALA A 377
ILE A 385
GLY A 384
THR A 339
ALA A 332
 None
 1.16A 3kw2A-4dx2A:
undetectable		 3kw2A-4dx2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		5 ALA A 105
ILE A  80
GLY A 107
LEU A   6
LEU A 188
 None
 0.98A 3kw2A-4fhaA:
2.3		 3kw2A-4fhaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ILE A 492
GLY A 423
LEU A 466
THR A 421
ALA A 419
 None
 1.09A 3kw2A-4ga6A:
undetectable		 3kw2A-4ga6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 ALA A  53
VAL A  55
ILE A   7
GLY A   8
THR A 137
 None
 1.10A 3kw2A-4gm6A:
undetectable		 3kw2A-4gm6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 ILE A 530
GLY A 485
SER A 463
LEU A 464
ALA A 536
 None
 1.21A 3kw2A-4h1gA:
undetectable		 3kw2A-4h1gA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ALA A 223
ILE A 228
GLY A 227
LEU A 254
LEU A 258
 None
 1.19A 3kw2A-4iuwA:
undetectable		 3kw2A-4iuwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw2 A3 ARTIFICIAL
PROTEIN

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A  68
ILE A  72
GLY A  42
LEU A  50
ALA A  46
 None
 1.17A 3kw2A-4jw2A:
undetectable		 3kw2A-4jw2A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36)
PF07504
(FTP) 		5 ALA A 362
GLY B  93
ASP B  94
LEU A 439
ALA A 572
 None
 1.24A 3kw2A-4k90A:
undetectable		 3kw2A-4k90A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL B 409
ILE B 498
GLY B 499
LEU B 513
ALA B 765
 None
None
None
GLU  B 921 (-4.5A)
None
 1.22A 3kw2A-4pe5B:
4.7		 3kw2A-4pe5B:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli) 		PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C) 		5 ALA B  49
GLY B  53
LEU B  70
LEU B  64
ALA B  63
 None
 1.14A 3kw2A-4r8uB:
undetectable		 3kw2A-4r8uB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Arthrobacter
sp. FB24) 		PF13377
(Peripla_BP_3) 		5 ILE A 279
GLY A 280
ASP A 255
LEU A 335
ALA A 174
 None
 1.13A 3kw2A-4rkrA:
undetectable		 3kw2A-4rkrA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 ALA A 119
ILE A  97
LEU A 115
LEU A  87
ALA A  86
 None
 1.01A 3kw2A-4v15A:
undetectable		 3kw2A-4v15A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 ILE A 356
GLY A 355
ASP A 316
LEU A 384
ALA A 327
 None
 1.17A 3kw2A-4wxbA:
undetectable		 3kw2A-4wxbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF05343
(Peptidase_M42) 		5 SER A 167
LEU A 166
LEU A 319
THR A 173
ALA A 172
 None
 1.15A 3kw2A-4x8iA:
undetectable		 3kw2A-4x8iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A 408
ARG A 407
ILE A 350
LEU A 284
LEU A 416
 None
None
ACT  A 504 ( 4.7A)
None
None
 1.10A 3kw2A-4xeaA:
undetectable		 3kw2A-4xeaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ALA C  99
ILE C 103
GLY C  73
LEU C  81
ALA C  77
 None
 1.16A 3kw2A-4xl5C:
undetectable		 3kw2A-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 ALA C 192
ILE C 196
GLY C 166
LEU C 174
ALA C 170
 None
 1.23A 3kw2A-4xl5C:
undetectable		 3kw2A-4xl5C:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG

(Haemophilus
influenzae) 		PF03595
(SLAC1) 		5 ALA A  84
ILE A  88
SER A  81
LEU A 144
ALA A 148
 None
 1.04A 3kw2A-4ycrA:
undetectable		 3kw2A-4ycrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B

(Methylobacterium
extorquens) 		PF12706
(Lactamase_B_2) 		5 ALA A 191
ARG A 189
ILE A 193
GLY A 180
LEU A 213
 None
 1.24A 3kw2A-4z7rA:
undetectable		 3kw2A-4z7rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ILE A 506
GLY A 503
SER A 105
LEU A 106
ALA A 568
 None
 1.15A 3kw2A-4zajA:
2.5		 3kw2A-4zajA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A 130
ILE A 134
GLY A 104
LEU A 112
ALA A 108
 None
 1.28A 3kw2A-4zv6A:
undetectable		 3kw2A-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A 192
ILE A 196
GLY A 166
LEU A 174
ALA A 170
 None
 1.26A 3kw2A-4zv6A:
undetectable		 3kw2A-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 ALA A 223
ILE A 227
GLY A 197
LEU A 205
ALA A 201
 None
 1.22A 3kw2A-4zv6A:
undetectable		 3kw2A-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1252
ILE A1206
GLY A1207
LEU A1603
ALA A1605
 None
 1.16A 3kw2A-5a31A:
undetectable		 3kw2A-5a31A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq ARTIFICIAL REPEAT
PROTEINS (ALPHAREP3)

(synthetic
construct) 		PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A  67
ILE A  71
GLY A  41
LEU A  49
ALA A  45
 None
 1.20A 3kw2A-5dcqA:
undetectable		 3kw2A-5dcqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq ARTIFICIAL REPEAT
PROTEINS (ALPHAREP3)

(synthetic
construct) 		PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 ALA A  98
ILE A 102
GLY A  72
LEU A  80
ALA A  76
 None
 1.21A 3kw2A-5dcqA:
undetectable		 3kw2A-5dcqA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 320
SER A 317
LEU A 316
THR A 341
ALA A 362
 None
 1.25A 3kw2A-5e7qA:
undetectable		 3kw2A-5e7qA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ALA A 393
ILE A 398
GLY A 397
LEU A 123
LEU A 184
 None
 1.02A 3kw2A-5egeA:
undetectable		 3kw2A-5egeA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ALA A 282
VAL A 286
LEU A 245
LEU A 238
ALA A 241
 None
 1.11A 3kw2A-5elxA:
2.7		 3kw2A-5elxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 VAL h 101
GLY h 106
SER h  87
THR h 514
ALA h 513
 None
 1.27A 3kw2A-5gw5h:
undetectable		 3kw2A-5gw5h:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ARG A 528
SER A 557
LEU A 558
THR A 516
ALA A 515
 None
 0.99A 3kw2A-5h3kA:
undetectable		 3kw2A-5h3kA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		5 ALA A 696
ILE A 713
GLY A 712
LEU A 671
ALA A 629
 None
 1.05A 3kw2A-5hlbA:
undetectable		 3kw2A-5hlbA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 657
ILE A 554
LEU A 573
LEU A 570
ALA A 580
 None
 1.06A 3kw2A-5i51A:
undetectable		 3kw2A-5i51A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C)
PF13155
(Toprim_2) 		5 ALA D 326
VAL D 420
GLY D 330
LEU D 339
THR D 390
 None
 1.16A 3kw2A-5iknD:
undetectable		 3kw2A-5iknD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		5 ARG A 292
GLY A  19
LEU A  34
THR A  23
ALA A  24
 ADP  A 402 (-4.3A)
ADP  A 402 (-3.1A)
None
None
None
 0.99A 3kw2A-5jygA:
undetectable		 3kw2A-5jygA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		5 VAL A 273
ILE A 261
GLY A 262
LEU A 259
LEU A 342
 None
 1.16A 3kw2A-5l2rA:
2.5		 3kw2A-5l2rA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A1252
ILE A1206
GLY A1207
LEU A1603
ALA A1605
 None
 1.26A 3kw2A-5lcwA:
undetectable		 3kw2A-5lcwA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE

(Acaryochloris
marina) 		no annotation 5 ALA A 546
ILE A 551
GLY A 544
LEU A 566
LEU A 567
 None
 0.95A 3kw2A-5lpcA:
undetectable		 3kw2A-5lpcA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltg AUTOPHAGY-RELATED
PROTEIN 18

(Ogataea angusta) 		no annotation 5 ALA A 284
ILE A 247
SER A 272
LEU A 273
ALA A 240
 None
 1.27A 3kw2A-5ltgA:
undetectable		 3kw2A-5ltgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 VAL A  53
ILE A 160
GLY A 161
THR A 197
ALA A 200
 None
 0.79A 3kw2A-5n0gA:
2.8		 3kw2A-5n0gA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 ALA A 191
ILE A 197
GLY A 196
LEU A 224
ALA A 223
 None
 1.21A 3kw2A-5nl7A:
undetectable		 3kw2A-5nl7A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o63 RESTRICTION
ENDONUCLEASE UBALAI

(unidentified) 		no annotation 5 ALA A   8
VAL A  12
ILE A 160
LEU A 112
ALA A  22
 None
 1.11A 3kw2A-5o63A:
undetectable		 3kw2A-5o63A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 ILE A 195
GLY A 196
LEU A 224
THR A 226
ALA A 229
 None
SAM  A 501 (-4.1A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
 0.20A 3kw2A-5o96A:
26.2		 3kw2A-5o96A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 VAL A 301
ILE A 184
ASP A 299
LEU A 550
ALA A 548
 None
 1.24A 3kw2A-5opqA:
2.9		 3kw2A-5opqA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ILE A  17
GLY A  14
SER A 124
LEU A 135
ALA A 130
 None
None
7VD  A 302 (-2.7A)
None
None
 1.05A 3kw2A-5u5gA:
3.4		 3kw2A-5u5gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uah RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		5 ALA F 431
ILE F 435
GLY F 411
SER F 428
LEU F 386
 None
 1.13A 3kw2A-5uahF:
undetectable		 3kw2A-5uahF:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ALA A 240
ARG A 244
ILE A 236
LEU A 262
ALA A 264
 None
 1.23A 3kw2A-5ujuA:
3.6		 3kw2A-5ujuA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vis DIHYDROPTEROATE
SYNTHASE

(soil metagenome) 		PF00809
(Pterin_bind) 		5 ALA A  81
ILE A  74
LEU A  37
LEU A  36
ALA A  33
 None
 1.24A 3kw2A-5visA:
undetectable		 3kw2A-5visA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjc PROTEIN MINI
SPINDLES

(Drosophila
melanogaster) 		no annotation 5 ALA A1356
ARG A1357
ILE A1374
LEU A1392
THR A1385
 None
 1.27A 3kw2A-5vjcA:
undetectable		 3kw2A-5vjcA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 ALA A 324
GLY A 320
LEU A 317
THR A 402
ALA A 405
 None
 0.92A 3kw2A-5ydjA:
undetectable		 3kw2A-5ydjA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 527
ILE A 523
GLY A 524
LEU A 503
THR A 531
 None
 1.00A 3kw2A-6c26A:
undetectable		 3kw2A-6c26A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM

(Porphyromonas
gingivalis) 		no annotation 5 ALA A 375
ILE A 352
LEU A 328
THR A 356
ALA A 366
 None
 1.14A 3kw2A-6ey5A:
undetectable		 3kw2A-6ey5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.23A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.23A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.13A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.17A 3kw2A-6ft5A:
undetectable		 3kw2A-6ft5A:
undetectable