SIMILAR PATTERNS OF AMINO ACIDS FOR 3KU1_H_SAMH226

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		5 GLY A 226
VAL A 237
ALA A 321
LEU A 316
ILE A 233
 None
 1.00A 3ku1H-1axkA:
undetectable		 3ku1H-1axkA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		5 LEU A 110
GLY A  42
GLY A 182
ALA A 114
ILE A 181
 None
HEM  A 400 ( 3.9A)
HEM  A 400 (-3.3A)
None
None
 1.00A 3ku1H-1bgpA:
undetectable		 3ku1H-1bgpA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 LEU A 176
VAL A  59
ALA A 131
LEU A  79
ILE A  51
 None
 1.02A 3ku1H-1bhwA:
undetectable		 3ku1H-1bhwA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		5 GLY A  19
GLY A  69
ALA A  93
LEU A 142
ILE A  22
 CL  A 385 ( 3.8A)
ADN  A 375 (-2.9A)
None
None
ADN  A 375 ( 4.3A)
 0.94A 3ku1H-1dgmA:
3.2		 3ku1H-1dgmA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		5 GLY A 201
VAL A 235
ALA A 144
LEU A 159
ILE A 135
 None
 0.98A 3ku1H-1iayA:
2.6		 3ku1H-1iayA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		5 ASP A 138
GLY A 182
ALA A 135
LEU A  95
ILE A 106
 None
 0.99A 3ku1H-1jm1A:
undetectable		 3ku1H-1jm1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 GLY A 453
VAL A 456
PRO A 335
ALA A 446
LEU A 413
 None
 0.96A 3ku1H-1k25A:
undetectable		 3ku1H-1k25A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		6 LEU A  76
GLY A 357
ASP A  71
VAL A 364
VAL A 365
ILE A 433
 None
 1.18A 3ku1H-1kcxA:
undetectable		 3ku1H-1kcxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		5 GLY C 179
VAL C 177
VAL C  86
ALA C 181
ILE C 188
 None
None
None
ACT  C1318 (-3.0A)
None
 1.01A 3ku1H-1odtC:
undetectable		 3ku1H-1odtC:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		5 ASP A  16
VAL A  23
GLY A  11
LEU A  51
ILE A  47
 None
 0.97A 3ku1H-1qgoA:
2.5		 3ku1H-1qgoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 5 LEU A 495
GLY A 438
ALA A 426
LEU A 291
ILE A 433
 None
 0.88A 3ku1H-1qi9A:
undetectable		 3ku1H-1qi9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		5 LEU A 101
GLY A 172
ALA A 105
LEU A 112
ILE A 171
 None
HEM  A 300 (-3.4A)
None
None
None
 1.02A 3ku1H-1schA:
undetectable		 3ku1H-1schA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		5 VAL A   6
GLY A 172
MET A 140
LEU A 143
ILE A 149
 None
 1.04A 3ku1H-1uh9A:
undetectable		 3ku1H-1uh9A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		no annotation 5 VAL B 767
VAL B 780
GLY B 749
ALA B 771
ILE B 748
 None
 1.04A 3ku1H-1us8B:
undetectable		 3ku1H-1us8B:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vct HYPOTHETICAL PROTEIN
PH0236

(Pyrococcus
horikoshii) 		PF01895
(PhoU)
PF02080
(TrkA_C) 		5 VAL A 155
PRO A 165
GLY A 124
LEU A 189
ILE A 186
 None
 0.93A 3ku1H-1vctA:
undetectable		 3ku1H-1vctA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 GLY A 194
VAL A 192
VAL A 191
ALA A 220
ILE A 296
 None
None
None
ANP  A 400 (-3.7A)
None
 0.99A 3ku1H-1vpeA:
2.9		 3ku1H-1vpeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02347
(GDC-P)
PF02347
(GDC-P) 		5 LEU B  50
GLY A 330
ALA A 335
LEU A 120
ILE A 117
 None
 0.99A 3ku1H-1wytB:
undetectable		 3ku1H-1wytB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 GLY A 236
ASP A 232
GLY A 107
ALA A 100
LEU A 243
 None
 1.05A 3ku1H-1x0lA:
undetectable		 3ku1H-1x0lA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 GLY A  77
GLY A  88
ALA A 114
LEU A 110
ILE A  74
 None
 1.02A 3ku1H-1xp3A:
undetectable		 3ku1H-1xp3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		5 VAL A 128
PRO A 126
ALA A 246
LEU A 252
ILE A 178
 None
 1.02A 3ku1H-2b6nA:
2.4		 3ku1H-2b6nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		5 LEU A 273
VAL A 169
GLY A 217
LEU A 262
ILE A 268
 None
 1.01A 3ku1H-2b9lA:
undetectable		 3ku1H-2b9lA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 ARG A 499
PRO A 186
GLY A 169
LEU A 194
ILE A 228
 None
None
FAD  A 525 (-3.5A)
None
FAD  A 525 (-4.0A)
 0.99A 3ku1H-2exrA:
undetectable		 3ku1H-2exrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 GLY A 280
ASP A 115
VAL A 111
LEU A  80
ILE A 269
 None
 1.03A 3ku1H-2fqxA:
2.5		 3ku1H-2fqxA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		5 GLY A 114
VAL A 558
PRO A 533
GLY A 236
ALA A 265
 None
 0.86A 3ku1H-2gq3A:
undetectable		 3ku1H-2gq3A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtp REGULATOR OF
G-PROTEIN SIGNALING
1

(Homo sapiens) 		PF00615
(RGS) 		5 GLY C  82
GLY C  87
ALA C  78
LEU C 103
ILE C  99
 None
 0.96A 3ku1H-2gtpC:
undetectable		 3ku1H-2gtpC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		5 GLY A  10
VAL A   7
VAL A 160
LEU A 120
ILE A 127
 FAD  A 501 ( 4.5A)
None
None
None
None
 1.04A 3ku1H-2i0zA:
2.3		 3ku1H-2i0zA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 ARG A 296
VAL A 278
ALA A 301
LEU A 307
ILE A 320
 None
 1.04A 3ku1H-2i44A:
undetectable		 3ku1H-2i44A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		5 GLY A 191
VAL A 189
VAL A 188
ALA A 217
ILE A 292
 None
 1.04A 3ku1H-2ie8A:
undetectable		 3ku1H-2ie8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 GLY A 129
GLY A 135
ALA A 104
LEU A 164
ILE A 110
 None
 1.05A 3ku1H-2o1bA:
3.6		 3ku1H-2o1bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		5 LEU A 169
GLY A  68
ASP A 269
VAL A  73
ALA A  96
 None
 0.90A 3ku1H-2p1rA:
2.3		 3ku1H-2p1rA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 GLY A 245
ASP A 243
PRO A 241
LEU A 222
ILE A 252
 None
 0.93A 3ku1H-2ri6A:
undetectable		 3ku1H-2ri6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		6 LEU A 222
GLY A 124
GLY A 127
ALA A 155
LEU A 137
ILE A 129
 None
 1.33A 3ku1H-2vfwA:
3.0		 3ku1H-2vfwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		5 LEU A 171
GLY A 142
GLY A  80
LEU A  69
ILE A  79
 None
 0.89A 3ku1H-2w3cA:
undetectable		 3ku1H-2w3cA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 GLY A 258
GLY A 274
ALA A 256
LEU A 332
ILE A 295
 None
 1.06A 3ku1H-2x0sA:
1.8		 3ku1H-2x0sA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		5 LEU A 772
GLY A 722
VAL A 823
PRO A 821
GLY A 696
 None
 0.98A 3ku1H-2x2iA:
undetectable		 3ku1H-2x2iA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		5 ARG A 154
LEU A 328
GLY A 171
VAL A 176
LEU A 254
 None
 1.05A 3ku1H-3bblA:
undetectable		 3ku1H-3bblA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234

(Pectobacterium
atrosepticum) 		PF06821
(Ser_hydrolase) 		5 ARG A   9
GLY A 100
ALA A 180
LEU A  17
ILE A  76
 EDO  A 196 (-3.8A)
None
None
None
None
 0.96A 3ku1H-3bdvA:
2.6		 3ku1H-3bdvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bil PROBABLE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF13407
(Peripla_BP_4) 		5 PRO A 129
GLY A  69
ALA A 299
LEU A 306
ILE A  68
 None
 0.93A 3ku1H-3bilA:
2.1		 3ku1H-3bilA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		6 LEU A 409
ASP A 473
VAL A 488
GLY A 531
LEU A 524
ILE A 528
 None
 1.47A 3ku1H-3bolA:
2.1		 3ku1H-3bolA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		5 GLY A 206
PRO A 265
GLY A 156
ALA A 208
ILE A 176
 None
 0.97A 3ku1H-3dasA:
undetectable		 3ku1H-3dasA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		5 GLY A  75
VAL A 302
VAL A 301
GLY A  81
ILE A  80
 None
 1.00A 3ku1H-3dh4A:
undetectable		 3ku1H-3dh4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		5 LEU A 108
GLY A 159
VAL A 115
ALA A  85
ILE A 133
 None
 0.94A 3ku1H-3e8pA:
undetectable		 3ku1H-3e8pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ASP A 422
VAL A 403
GLY A 413
ALA A 432
LEU A 440
 None
 1.00A 3ku1H-3fefA:
4.4		 3ku1H-3fefA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpv EXTRACELLULAR
HAEM-BINDING PROTEIN

(Streptomyces
reticuli) 		PF03928
(Haem_degrading) 		5 VAL A  56
VAL A  65
GLY A 131
ALA A 149
LEU A 154
 None
 1.04A 3ku1H-3fpvA:
undetectable		 3ku1H-3fpvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
 None
 0.82A 3ku1H-3gcwA:
2.7		 3ku1H-3gcwA:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		11 ARG A  15
LEU A  16
GLY A  33
VAL A  57
VAL A  58
PRO A  61
GLY A  85
ALA A 101
MET A 103
LEU A 107
ILE A 111
 None
 0.43A 3ku1H-3gnlA:
31.6		 3ku1H-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		6 GLY A  33
ASP A  35
GLY A  85
MET A 103
LEU A 107
ILE A 111
 None
 0.82A 3ku1H-3gnlA:
31.6		 3ku1H-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		7 LEU A  39
GLY A  33
PRO A  61
ALA A 101
MET A 103
LEU A 107
ILE A 111
 None
 1.41A 3ku1H-3gnlA:
31.6		 3ku1H-3gnlA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		5 LEU A 171
GLY A 142
GLY A  80
LEU A  69
ILE A  79
 None
 0.96A 3ku1H-3gq2A:
undetectable		 3ku1H-3gq2A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 523
VAL A 320
ALA A 361
LEU A 308
ILE A 243
 None
 1.01A 3ku1H-3gyrA:
undetectable		 3ku1H-3gyrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		5 GLY A 153
VAL A 158
VAL A 159
ALA A 149
LEU A 252
 None
 1.01A 3ku1H-3i09A:
2.3		 3ku1H-3i09A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 LEU A 513
GLY A 417
VAL A 502
GLY A 485
LEU A 458
 None
 1.00A 3ku1H-3j1cA:
undetectable		 3ku1H-3j1cA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 5 LEU B 355
GLY B 438
MET B 388
LEU B 412
ILE B 440
 None
 1.04A 3ku1H-3jruB:
undetectable		 3ku1H-3jruB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR

(Chlorobaculum
tepidum) 		PF13185
(GAF_2) 		5 VAL A  52
GLY A 130
ALA A 160
LEU A 165
ILE A 129
 None
 1.03A 3ku1H-3k2nA:
undetectable		 3ku1H-3k2nA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 LEU A  17
GLY A  29
VAL A  71
GLY A  49
LEU A  54
 None
 1.03A 3ku1H-3k94A:
undetectable		 3ku1H-3k94A:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		9 ARG A   5
GLY A  23
ASP A  25
VAL A  48
GLY A  75
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 0.93A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		10 ARG A   5
GLY A  23
VAL A  47
VAL A  48
PRO A  51
GLY A  75
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 0.71A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		10 LEU A   6
GLY A  23
VAL A  47
VAL A  48
PRO A  51
GLY A  75
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 0.47A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		6 LEU A  29
PRO A  51
ALA A  91
MET A  93
LEU A  97
ILE A 101
 None
 1.44A 3ku1H-3kr9A:
34.9		 3ku1H-3kr9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		5 GLY A 135
VAL A 146
ALA A  44
LEU A  39
ILE A 142
 None
 1.05A 3ku1H-3lb9A:
undetectable		 3ku1H-3lb9A:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN

(Streptococcus
agalactiae) 		PF04816
(TrmK) 		10 ARG A   8
LEU A   9
GLY A  26
VAL A  50
VAL A  51
PRO A  54
GLY A  78
MET A  96
LEU A 100
ILE A 104
 None
None
None
None
None
None
None
None
SO4  A 229 ( 4.7A)
None
 0.65A 3ku1H-3lecA:
18.4		 3ku1H-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN

(Streptococcus
agalactiae) 		PF04816
(TrmK) 		7 GLY A  26
ASP A  28
VAL A  50
GLY A  78
MET A  96
LEU A 100
ILE A 104
 None
None
None
None
None
SO4  A 229 ( 4.7A)
None
 0.95A 3ku1H-3lecA:
18.4		 3ku1H-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN

(Streptococcus
agalactiae) 		PF04816
(TrmK) 		6 GLY A  48
VAL A  50
VAL A  51
PRO A  54
GLY A  78
ILE A 104
 None
 1.42A 3ku1H-3lecA:
18.4		 3ku1H-3lecA:
61.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 GLY A1015
VAL A1104
ALA A1077
LEU A1195
ILE A1199
 None
 1.03A 3ku1H-3mmpA:
undetectable		 3ku1H-3mmpA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofj NODULATION PROTEIN S

(Bradyrhizobium
sp. WM9) 		PF05401
(NodS) 		5 ARG A  31
GLY A  52
VAL A  74
ALA A 114
ILE A  99
 None
 0.99A 3ku1H-3ofjA:
12.9		 3ku1H-3ofjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 LEU C 317
GLY C 280
VAL C 257
ALA C 277
ILE C 274
 None
 1.02A 3ku1H-3qgkC:
undetectable		 3ku1H-3qgkC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation
no annotation 		5 LEU N 176
PRO K   3
GLY J   9
ALA K  12
ILE J  13
 None
 0.94A 3ku1H-3rkoN:
undetectable		 3ku1H-3rkoN:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		5 LEU A 171
GLY A  34
VAL A  59
PRO A  61
GLY A  30
 None
 1.03A 3ku1H-3tc2A:
undetectable		 3ku1H-3tc2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 LEU A 448
GLY A 594
PRO A 517
LEU A 379
ILE A 369
 None
 1.02A 3ku1H-3tlmA:
2.6		 3ku1H-3tlmA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 ARG A 100
GLY A 220
MET A  51
LEU A  55
ILE A 190
 PO4  A 324 (-3.8A)
None
PO4  A 323 (-3.8A)
None
None
 0.92A 3ku1H-3ts7A:
undetectable		 3ku1H-3ts7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 VAL A 376
GLY A 419
ALA A 390
LEU A 397
ILE A 404
 None
 0.99A 3ku1H-3tviA:
2.0		 3ku1H-3tviA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		5 GLY A  70
VAL A  81
ALA A 165
LEU A 160
ILE A  77
 None
 1.04A 3ku1H-3vzmA:
undetectable		 3ku1H-3vzmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 GLY H 255
PRO H 251
GLY H 212
LEU H 419
ILE H 388
 None
 1.03A 3ku1H-4cr4H:
undetectable		 3ku1H-4cr4H:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 LEU A 552
PRO A 381
ALA A 556
LEU A 562
ILE A 526
 None
 1.00A 3ku1H-4db4A:
2.9		 3ku1H-4db4A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 GLY A 114
VAL A 563
PRO A 538
GLY A 237
ALA A 266
 None
 0.86A 3ku1H-4ex4A:
undetectable		 3ku1H-4ex4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		6 LEU A 282
GLY A 268
VAL A 263
VAL A 262
GLY A 238
ALA A 296
 None
 1.16A 3ku1H-4fwmA:
undetectable		 3ku1H-4fwmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 ARG A  81
GLY A 105
VAL A 157
ALA A  63
LEU A 132
 GOL  A 301 (-3.5A)
None
None
GOL  A 301 ( 4.4A)
None
 1.06A 3ku1H-4fzwA:
undetectable		 3ku1H-4fzwA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrt GLOBIN-2 A CHAIN

(Scapharca
inaequivalvis) 		PF00042
(Globin) 		5 VAL A 144
VAL A 145
ALA A 135
LEU A  18
ILE A  14
 None
 0.80A 3ku1H-4hrtA:
undetectable		 3ku1H-4hrtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica;
Salmonella
enterica) 		PF03372
(Exo_endo_phos)
PF02917
(Pertussis_S1) 		5 LEU G 138
GLY F 150
VAL F 133
GLY F 148
ILE F 124
 None
 1.01A 3ku1H-4k6lG:
undetectable		 3ku1H-4k6lG:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 VAL B 284
PRO B 282
ALA B 409
LEU B 415
ILE B 334
 None
 0.84A 3ku1H-4ov6B:
2.3		 3ku1H-4ov6B:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		6 LEU A1038
VAL A 957
GLY A 982
ALA A1010
LEU A 988
ILE A 981
 None
 1.01A 3ku1H-4u48A:
undetectable		 3ku1H-4u48A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 PRO B 428
GLY B 416
ALA B 197
LEU B 178
ILE B 415
 None
 1.04A 3ku1H-5a8rB:
undetectable		 3ku1H-5a8rB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		5 LEU A 142
GLY A  74
GLY A 214
ALA A 146
ILE A 213
 None
HEM  A1341 (-3.6A)
HEM  A1341 (-3.4A)
None
None
 1.03A 3ku1H-5aogA:
undetectable		 3ku1H-5aogA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 VAL A 177
GLY A 127
ALA A 214
LEU A 138
ILE A 128
 None
None
NAD  A 401 (-4.2A)
None
None
 0.97A 3ku1H-5dt9A:
5.8		 3ku1H-5dt9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzu ASPARTIC PROTEASE
INHIBITOR 11

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		5 LEU A 173
GLY A  34
VAL A  59
PRO A  61
GLY A  30
 None
 1.03A 3ku1H-5dzuA:
undetectable		 3ku1H-5dzuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		5 ASP A 312
VAL A 264
ALA A 260
LEU A 254
ILE A 227
 None
 1.05A 3ku1H-5epdA:
undetectable		 3ku1H-5epdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		5 LEU A 342
GLY A 367
VAL A 420
GLY A 417
ILE A 416
 None
 0.79A 3ku1H-5fnuA:
undetectable		 3ku1H-5fnuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnx POTATO STI-KUNITZ
BI-FUNCTIONAL
INHIBITOR E3AD_N19D

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		5 LEU A 172
GLY A  34
VAL A  59
PRO A  61
GLY A  30
 None
 0.98A 3ku1H-5fnxA:
undetectable		 3ku1H-5fnxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		6 LEU A 562
VAL A 209
GLY A 178
ALA A 156
LEU A 232
ILE A 177
 None
 1.45A 3ku1H-5haxA:
undetectable		 3ku1H-5haxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		5 LEU A 713
VAL A 642
GLY A 226
LEU A 621
ILE A 209
 None
 0.82A 3ku1H-5jwfA:
undetectable		 3ku1H-5jwfA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 LEU A 301
VAL A 186
PRO A 184
ALA A 178
LEU A 240
 None
 0.95A 3ku1H-5l2pA:
undetectable		 3ku1H-5l2pA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lac 3CL PROTEASE

(Alphamesonivirus
1) 		PF17222
(Peptidase_C107) 		5 GLY A 154
VAL A  38
PRO A  21
GLY A 166
LEU A  89
 None
 1.04A 3ku1H-5lacA:
undetectable		 3ku1H-5lacA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE

(Giardia
intestinalis) 		PF07992
(Pyr_redox_2) 		5 LEU A 265
GLY A 299
GLY A  22
ALA A 280
ILE A  11
 None
 0.86A 3ku1H-5m5jA:
2.6		 3ku1H-5m5jA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9y ZINC TRANSPORT
PROTEIN ZNTB

(Escherichia
coli) 		no annotation 5 LEU A 134
VAL A  11
GLY A   6
LEU A 115
ILE A  35
 None
 1.01A 3ku1H-5n9yA:
undetectable		 3ku1H-5n9yA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 VAL E 183
PRO E 185
GLY E 180
LEU E 318
ILE E 154
 EDO  E 503 ( 3.1A)
None
None
None
None
 0.98A 3ku1H-5nkmE:
undetectable		 3ku1H-5nkmE:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 114
VAL A 556
PRO A 531
GLY A 237
ALA A 266
 None
 0.92A 3ku1H-5oasA:
undetectable		 3ku1H-5oasA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		5 ARG A1176
GLY A1146
VAL A1197
GLY A1154
ILE A1192
 None
None
NAG  A1472 ( 3.4A)
None
None
 0.94A 3ku1H-5szsA:
undetectable		 3ku1H-5szsA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		5 LEU A  99
GLY A 170
ALA A 103
LEU A 110
ILE A 169
 None
HEM  A 301 (-3.0A)
None
None
None
 1.05A 3ku1H-5twtA:
undetectable		 3ku1H-5twtA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
 None
 0.73A 3ku1H-5vlhA:
undetectable		 3ku1H-5vlhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 5 LEU A 353
GLY A 288
GLY A 213
LEU A 249
ILE A 284
 None
 0.85A 3ku1H-5wkaA:
undetectable		 3ku1H-5wkaA:
undetectable