SIMILAR PATTERNS OF AMINO ACIDS FOR 3KU1_G_SAMG226_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens)
PF00135
(COesterase)
5 LEU A 324
GLY A 210
PRO A 312
GLY A 205
ILE A 118
None
1.08A 3ku1G-1b41A:
undetectable
3ku1G-1b41A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chm CREATINE
AMIDINOHYDROLASE


(Pseudomonas
putida)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 LEU A  31
ALA A  43
GLY A 122
LEU A 136
ILE A 111
None
1.15A 3ku1G-1chmA:
undetectable
3ku1G-1chmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus)
PF04389
(Peptidase_M28)
5 GLY A  64
GLY A 137
ALA A  62
GLY A  61
ILE A 136
None
1.13A 3ku1G-1f2pA:
undetectable
3ku1G-1f2pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia)
PF00390
(malic)
PF03949
(Malic_M)
5 GLY A 163
ASP A 256
GLY A 206
GLY A 170
LEU A 212
None
MN  A1584 ( 2.5A)
None
None
None
1.19A 3ku1G-1gq2A:
undetectable
3ku1G-1gq2A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2h HYPOTHETICAL PROTEIN
TM1643


(Thermotoga
maritima)
PF01958
(DUF108)
PF03447
(NAD_binding_3)
5 LEU A 222
GLY A 170
GLY A 111
LEU A 116
ILE A 172
None
1.12A 3ku1G-1h2hA:
5.2
3ku1G-1h2hA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi)
PF00710
(Asparaginase)
5 LEU A 174
ASN A  59
GLY A  32
GLY A 131
LEU A  39
None
1.11A 3ku1G-1hg0A:
undetectable
3ku1G-1hg0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae)
PF00291
(PALP)
PF14821
(Thr_synth_N)
5 ASP A 389
ASN A 338
GLY A 280
ALA A 288
ILE A 247
None
None
PLP  A1400 (-3.8A)
None
None
1.08A 3ku1G-1kl7A:
undetectable
3ku1G-1kl7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia)
PF13354
(Beta-lactamase2)
5 ASP A 242
ALA A  41
GLY A  42
LEU A  36
ILE A  27
None
0.92A 3ku1G-1n4oA:
undetectable
3ku1G-1n4oA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ois DNA TOPOISOMERASE I

(Saccharomyces
cerevisiae)
PF02919
(Topoisom_I_N)
5 LEU A 177
GLY A 303
ALA A 185
GLY A 186
LEU A 191
None
1.18A 3ku1G-1oisA:
undetectable
3ku1G-1oisA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouv CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF08238
(Sel1)
5 GLY A 135
GLY A 140
GLY A 104
LEU A 121
ILE A 142
None
1.19A 3ku1G-1ouvA:
undetectable
3ku1G-1ouvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3h DEPHOSPHO-COA KINASE

(Escherichia
coli)
PF01121
(CoaE)
5 GLY A   9
VAL A 132
GLY A  12
LEU A 156
ILE A  11
None
None
SO4  A 301 (-3.2A)
None
None
1.17A 3ku1G-1t3hA:
undetectable
3ku1G-1t3hA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE


(Pinus
sylvestris)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 LEU A 266
GLY A 166
GLY A 375
GLY A 258
LEU A 380
None
1.10A 3ku1G-1u0uA:
undetectable
3ku1G-1u0uA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN


(Pyrococcus
horikoshii)
PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C)
5 GLY A 278
ASN A 310
GLY A 284
LEU A   9
ILE A 281
None
None
SO4  A1406 (-4.1A)
None
None
1.09A 3ku1G-1uz5A:
undetectable
3ku1G-1uz5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF00291
(PALP)
5 LEU A 234
GLY A 173
PRO A 201
GLY A 177
ILE A  39
None
None
None
PLP  A 413 (-3.8A)
None
0.89A 3ku1G-1ve1A:
2.6
3ku1G-1ve1A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2


(Equus caballus)
PF00151
(Lipase)
PF01477
(PLAT)
5 GLY X 127
ALA X 160
GLY X 161
LEU X 167
ILE X 134
None
1.01A 3ku1G-1w52X:
undetectable
3ku1G-1w52X:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]


(Neisseria
meningitidis)
no annotation 5 GLY C 124
GLY C 103
ALA C 121
GLY C 114
LEU C 173
None
1.09A 3ku1G-2aqtC:
undetectable
3ku1G-2aqtC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA


(Mycobacterium
tuberculosis)
PF13184
(KH_5)
5 ARG A 162
GLY A 136
ALA A 116
GLY A 117
ILE A 179
None
1.18A 3ku1G-2asbA:
undetectable
3ku1G-2asbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE


(Pyrococcus
horikoshii)
PF00390
(malic)
PF03949
(Malic_M)
5 GLY A 209
ALA A 171
GLY A 172
LEU A 177
ILE A 184
None
0.97A 3ku1G-2dvmA:
undetectable
3ku1G-2dvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ARG A 208
GLY A 129
ALA A 171
GLY A 168
ILE A 412
None
0.86A 3ku1G-2e6kA:
undetectable
3ku1G-2e6kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4


(Escherichia
coli)
PF02113
(Peptidase_S13)
5 ARG A 316
GLY A 251
GLY A 256
ALA A 166
ILE A 137
None
1.10A 3ku1G-2exaA:
undetectable
3ku1G-2exaA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Thermus
thermophilus)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 GLY A 369
GLY A 339
ALA A 328
LEU A 342
ILE A 340
SO4  A 419 ( 4.8A)
None
None
None
None
1.04A 3ku1G-2ip4A:
4.2
3ku1G-2ip4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3s FILAMIN-A

(Homo sapiens)
PF00630
(Filamin)
5 LEU A2162
PRO A2181
GLY A2237
ALA A2266
GLY A2267
None
0.83A 3ku1G-2j3sA:
undetectable
3ku1G-2j3sA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfu GNA2132

(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
5 VAL A 401
GLY A 376
ALA A 314
GLY A 315
ILE A 372
None
0.77A 3ku1G-2lfuA:
undetectable
3ku1G-2lfuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica)
PF00781
(DAGK_cat)
5 LEU A 169
GLY A  68
ASP A 269
VAL A  73
ALA A  96
None
0.84A 3ku1G-2p1rA:
undetectable
3ku1G-2p1rA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE


(Thermus
aquaticus)
PF00772
(DnaB)
PF03796
(DnaB_C)
5 GLY A 233
ASP A 288
GLY A 312
LEU A 352
ILE A 354
None
1.02A 3ku1G-2q6tA:
undetectable
3ku1G-2q6tA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum)
PF00701
(DHDPS)
5 GLY A 221
ALA A 204
GLY A 205
LEU A 210
ILE A 220
None
0.85A 3ku1G-2r8wA:
undetectable
3ku1G-2r8wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Candida
albicans)
PF01704
(UDPGP)
5 LEU A 117
GLY A 112
ASN A 198
GLY A 171
GLY A 124
None
1.01A 3ku1G-2yqhA:
undetectable
3ku1G-2yqhA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus)
PF13091
(PLDc_2)
5 GLY A 359
ASP A 355
ASN A 419
GLY A 364
ALA A 326
None
1.19A 3ku1G-2ze4A:
1.9
3ku1G-2ze4A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE


(Plectranthus
scutellarioides)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 241
VAL A 147
ALA A 253
GLY A 252
LEU A 116
None
0.89A 3ku1G-3bazA:
6.4
3ku1G-3bazA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA
HEMOGLOBIN BETA


(Perca
flavescens;
Perca
flavescens)
PF00042
(Globin)
PF00042
(Globin)
5 GLY A  30
VAL A  35
GLY B 124
ALA A  26
GLY A  25
None
0.91A 3ku1G-3bj1A:
undetectable
3ku1G-3bj1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c41 AMINO ACID ABC
TRANSPORTER (ARTP)


(Geobacillus
stearothermophilus)
PF00005
(ABC_tran)
5 LEU J 151
VAL J  30
GLY J  80
LEU J  47
ILE J   2
None
1.11A 3ku1G-3c41J:
undetectable
3ku1G-3c41J:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT


(Escherichia
coli)
PF13085
(Fer2_3)
PF13183
(Fer4_8)
5 GLY B 152
PRO B  73
GLY B  63
ALA B 171
ILE B 149
SF4  B 246 (-4.2A)
None
FES  B 244 (-3.7A)
SF4  B 246 ( 3.8A)
SF4  B 246 (-4.9A)
1.12A 3ku1G-3cirB:
undetectable
3ku1G-3cirB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C


(Toxoplasma
gondii)
PF00481
(PP2C)
5 GLY A 343
VAL A 341
ALA A 345
GLY A 346
ILE A 357
None
1.10A 3ku1G-3d8kA:
undetectable
3ku1G-3d8kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 LEU A 500
ASN A 147
GLY A 146
ALA A 559
GLY A 558
CU  A 602 ( 4.9A)
None
None
None
None
1.19A 3ku1G-3dkhA:
undetectable
3ku1G-3dkhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga2 ENDONUCLEASE V

(Bacillus
subtilis)
PF04493
(Endonuclease_5)
5 ARG A 214
LEU A 215
GLY A 117
GLY A 127
LEU A 148
None
1.06A 3ku1G-3ga2A:
undetectable
3ku1G-3ga2A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
5 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
None
0.80A 3ku1G-3gcwA:
2.2
3ku1G-3gcwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE


(Streptomyces
avermitilis)
PF00378
(ECH_1)
5 LEU A 111
GLY A 139
VAL A 170
ALA A 115
GLY A 119
None
1.14A 3ku1G-3gkbA:
undetectable
3ku1G-3gkbA:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472


(Listeria
monocytogenes)
PF04816
(TrmK)
11 ARG A  15
LEU A  16
GLY A  33
VAL A  57
PRO A  61
ASN A  84
GLY A  85
ALA A 101
GLY A 102
LEU A 107
ILE A 111
None
0.42A 3ku1G-3gnlA:
31.8
3ku1G-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472


(Listeria
monocytogenes)
PF04816
(TrmK)
8 GLY A  33
ASP A  35
VAL A  57
ASN A  84
GLY A  85
GLY A 102
LEU A 107
ILE A 111
None
0.77A 3ku1G-3gnlA:
31.8
3ku1G-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472


(Listeria
monocytogenes)
PF04816
(TrmK)
5 GLY A  55
VAL A  57
ASN A  84
GLY A  85
ILE A 111
None
1.03A 3ku1G-3gnlA:
31.8
3ku1G-3gnlA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE


(Roystonea regia)
PF00141
(peroxidase)
5 LEU A 101
GLY A  35
GLY A 172
ALA A 105
ILE A 171
None
HEM  A 305 ( 3.7A)
HEM  A 305 ( 3.2A)
None
EDO  A 335 (-3.8A)
0.99A 3ku1G-3hdlA:
undetectable
3ku1G-3hdlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5


(Homo sapiens)
PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP)
5 ARG A 352
ASP A 567
VAL A 570
PRO A 566
LEU A 344
None
1.12A 3ku1G-3ihpA:
undetectable
3ku1G-3ihpA:
13.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
9 ARG A   5
ASP A  25
VAL A  47
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
None
0.73A 3ku1G-3kr9A:
34.9
3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
9 ARG A   5
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
None
0.64A 3ku1G-3kr9A:
34.9
3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
9 GLY A  23
ASP A  25
VAL A  47
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
None
0.60A 3ku1G-3kr9A:
34.9
3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
5 GLY A  45
VAL A  47
ASN A  74
GLY A  75
ILE A 101
None
1.05A 3ku1G-3kr9A:
34.9
3ku1G-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
10 LEU A   6
GLY A  23
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
LEU A  97
ILE A 101
None
0.50A 3ku1G-3kr9A:
34.9
3ku1G-3kr9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8h PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bordetella
bronchiseptica)
PF13242
(Hydrolase_like)
5 GLY A 138
ALA A 140
GLY A 120
LEU A   3
ILE A   5
None
1.08A 3ku1G-3l8hA:
2.2
3ku1G-3l8hA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN


(Streptococcus
agalactiae)
PF04816
(TrmK)
8 ARG A   8
LEU A   9
GLY A  26
VAL A  50
PRO A  54
GLY A  78
GLY A  95
ILE A 104
None
0.51A 3ku1G-3lecA:
32.9
3ku1G-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN


(Streptococcus
agalactiae)
PF04816
(TrmK)
8 ARG A   8
LEU A   9
GLY A  26
VAL A  50
PRO A  54
GLY A  95
LEU A 100
ILE A 104
None
None
None
None
None
None
SO4  A 229 ( 4.7A)
None
0.54A 3ku1G-3lecA:
32.9
3ku1G-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN


(Streptococcus
agalactiae)
PF04816
(TrmK)
5 GLY A  26
ASP A  28
VAL A  50
GLY A  78
ILE A 104
None
0.84A 3ku1G-3lecA:
32.9
3ku1G-3lecA:
61.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN


(Streptococcus
agalactiae)
PF04816
(TrmK)
5 GLY A  26
ASP A  28
VAL A  50
LEU A 100
ILE A 104
None
None
None
SO4  A 229 ( 4.7A)
None
0.84A 3ku1G-3lecA:
32.9
3ku1G-3lecA:
61.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus)
PF00704
(Glyco_hydro_18)
5 VAL A 224
ALA A 271
GLY A 258
LEU A 209
ILE A 212
None
0.99A 3ku1G-3n11A:
undetectable
3ku1G-3n11A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica)
PF00390
(malic)
PF03949
(Malic_M)
5 GLY A 242
ALA A 204
GLY A 205
LEU A 210
ILE A 217
None
1.10A 3ku1G-3nv9A:
3.6
3ku1G-3nv9A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2x COLLAGENASE 3

(Homo sapiens)
PF00413
(Peptidase_M10)
5 LEU A1254
GLY A1225
GLY A1197
LEU A1118
ILE A1163
None
1.05A 3ku1G-3o2xA:
undetectable
3ku1G-3o2xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p02 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF14274
(DUF4361)
PF16343
(DUF4973)
5 GLY A 315
ASP A 292
GLY A 184
LEU A 206
ILE A 204
None
1.13A 3ku1G-3p02A:
undetectable
3ku1G-3p02A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Vibrio cholerae)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 ASP A 108
ASN A  94
ALA A 128
GLY A 126
ILE A 228
AMP  A 501 (-3.0A)
None
None
None
None
1.06A 3ku1G-3p4eA:
undetectable
3ku1G-3p4eA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7h ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Coxiella
burnetii)
PF00574
(CLP_protease)
5 LEU A 155
GLY A 101
ALA A 106
GLY A 107
LEU A  63
None
0.92A 3ku1G-3q7hA:
undetectable
3ku1G-3q7hA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2


(Helicobacter
mustelae)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 LEU C 317
GLY C 280
VAL C 257
ALA C 277
ILE C 274
None
0.96A 3ku1G-3qgkC:
undetectable
3ku1G-3qgkC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli;
Escherichia
coli;
Escherichia
coli)
no annotation
no annotation
no annotation
5 LEU N 176
PRO K   3
GLY J   9
ALA K  12
ILE J  13
None
0.90A 3ku1G-3rkoN:
undetectable
3ku1G-3rkoN:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnl SULFOTRANSFERASE

(Alicyclobacillus
acidocaldarius)
PF13469
(Sulfotransfer_3)
5 GLY A  17
ALA A  13
GLY A  12
LEU A 110
ILE A 183
None
None
None
None
GOL  A 314 (-4.3A)
0.99A 3ku1G-3rnlA:
undetectable
3ku1G-3rnlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
ulcerans)
PF13561
(adh_short_C2)
5 VAL A  12
ALA A  45
GLY A  46
LEU A  51
ILE A  61
None
0.87A 3ku1G-3svtA:
6.6
3ku1G-3svtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE


(Leishmania
donovani)
PF00291
(PALP)
5 GLY A 188
VAL A 236
ALA A 183
GLY A 184
ILE A 245
LLP  A  51 ( 3.4A)
None
None
None
None
1.08A 3ku1G-3tbhA:
3.3
3ku1G-3tbhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus)
PF00480
(ROK)
5 LEU A  88
GLY A  10
GLY A 133
ALA A  64
GLY A  63
None
ANP  A 325 (-3.4A)
BGC  A 324 ( 3.9A)
None
None
1.17A 3ku1G-3vglA:
undetectable
3ku1G-3vglA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 GLY A2072
ALA A2021
GLY A2020
LEU A2067
ILE A2046
None
0.99A 3ku1G-3vkgA:
undetectable
3ku1G-3vkgA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E


(Rhodococcus
jostii)
PF00890
(FAD_binding_2)
5 LEU A  96
GLY A 469
VAL A 167
GLY A  64
GLY A 148
None
FAD  A1493 ( 3.1A)
None
ACT  A1491 ( 3.2A)
None
0.88A 3ku1G-4at0A:
undetectable
3ku1G-4at0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE


(Homo sapiens)
PF02668
(TauD)
PF06155
(DUF971)
5 LEU A 217
ASP A 204
PRO A 206
GLY A 234
GLY A 348
None
ZN  A 402 (-2.6A)
None
None
None
1.12A 3ku1G-4bhiA:
undetectable
3ku1G-4bhiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG


(Saccharomyces
cerevisiae)
PF00004
(AAA)
5 GLY H 255
PRO H 251
GLY H 212
LEU H 419
ILE H 388
None
0.99A 3ku1G-4cr4H:
undetectable
3ku1G-4cr4H:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo7 METHIONINE
AMINOPEPTIDASE


(Pseudomonas
aeruginosa)
PF00557
(Peptidase_M24)
5 GLY A 186
ALA A 188
GLY A 189
LEU A 145
ILE A 148
None
1.14A 3ku1G-4fo7A:
undetectable
3ku1G-4fo7A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE


(Drosophila
melanogaster)
PF01144
(CoA_trans)
5 GLY A 420
ASP A 424
ASN A 361
GLY A 363
ILE A 319
None
1.18A 3ku1G-4kgbA:
undetectable
3ku1G-4kgbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB


(Staphylococcus
epidermidis)
PF00083
(Sugar_tr)
5 GLY A  63
GLY A 111
GLY A  70
LEU A  77
ILE A  78
None
0.95A 3ku1G-4ldsA:
undetectable
3ku1G-4ldsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 GLY A 192
VAL A 218
ALA A 188
GLY A 214
ILE A 207
None
1.03A 3ku1G-4m7eA:
undetectable
3ku1G-4m7eA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens)
PF00630
(Filamin)
5 ARG A 664
GLY A 702
GLY A 729
GLY A 750
LEU A 707
None
1.18A 3ku1G-4m9pA:
undetectable
3ku1G-4m9pA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
5 PRO A 194
GLY A 177
GLY A 225
LEU A 202
ILE A 236
None
FAD  A 601 (-3.5A)
None
None
FAD  A 601 (-3.9A)
0.97A 3ku1G-4oalA:
undetectable
3ku1G-4oalA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
5 VAL B 284
PRO B 282
ALA B 409
LEU B 415
ILE B 334
None
0.81A 3ku1G-4ov6B:
undetectable
3ku1G-4ov6B:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE


(Arabidopsis
thaliana)
PF01546
(Peptidase_M20)
5 LEU A  73
GLY A 156
GLY A 462
GLY A 150
ILE A 440
None
None
None
MN  A 501 ( 4.0A)
None
0.93A 3ku1G-4pxbA:
undetectable
3ku1G-4pxbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A2905
VAL A2657
ALA A2552
GLY A2551
LEU A2641
None
0.75A 3ku1G-4qyrA:
undetectable
3ku1G-4qyrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA


(Escherichia
coli)
PF03611
(EIIC-GAT)
5 LEU A  23
GLY A 193
ASP A 314
GLY A 171
GLY A 134
None
None
ASC  A 501 (-2.7A)
None
None
1.16A 3ku1G-4rp8A:
undetectable
3ku1G-4rp8A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297)
no annotation 5 GLY A 496
ASP A 479
GLY A 519
GLY A 525
ILE A 548
None
0.98A 3ku1G-4ru5A:
undetectable
3ku1G-4ru5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usc PEROXIDASE

(Trachycarpus
fortunei)
PF00141
(peroxidase)
5 LEU A 101
GLY A  35
GLY A 172
ALA A 105
ILE A 171
None
HEM  A1318 (-3.4A)
HEM  A1318 (-3.1A)
None
None
0.98A 3ku1G-4uscA:
undetectable
3ku1G-4uscA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens)
PF03283
(PAE)
5 LEU A 375
GLY A 266
GLY A 234
GLY A 321
LEU A 240
None
1.15A 3ku1G-4uz1A:
undetectable
3ku1G-4uz1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbh PROTEIN NOTUM
HOMOLOG


(Homo sapiens)
PF03283
(PAE)
5 LEU A 375
GLY A 266
GLY A 234
GLY A 321
LEU A 240
None
1.11A 3ku1G-4wbhA:
undetectable
3ku1G-4wbhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E


(Alteromonas sp.)
PF00557
(Peptidase_M24)
5 LEU A 225
GLY A 333
GLY A 383
LEU A 282
ILE A 380
None
1.07A 3ku1G-4zwoA:
undetectable
3ku1G-4zwoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 ASN A  60
GLY A   8
ALA A  68
LEU A  30
ILE A  20
None
1.13A 3ku1G-5a3yA:
undetectable
3ku1G-5a3yA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA


(Methanothermobacter
marburgensis)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 PRO B 428
GLY B 416
ALA B 197
LEU B 178
ILE B 415
None
1.06A 3ku1G-5a8rB:
undetectable
3ku1G-5a8rB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN


(Burkholderia
cenocepacia)
PF01032
(FecCD)
5 GLY A  94
VAL A 275
ALA A 316
GLY A 315
ILE A 285
None
1.11A 3ku1G-5b58A:
undetectable
3ku1G-5b58A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct)
PF00290
(Trp_syntA)
5 GLY A  26
ASP A  29
GLY A  51
GLY A  75
ILE A  52
None
1.18A 3ku1G-5ey5A:
undetectable
3ku1G-5ey5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans)
PF01039
(Carboxyl_trans)
5 GLY A 158
ALA A 201
GLY A 202
LEU A 207
ILE A 221
None
1.03A 3ku1G-5fifA:
undetectable
3ku1G-5fifA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52


(Chlamydomonas
reinhardtii)
PF09822
(ABC_transp_aux)
5 LEU A  91
PRO A 182
GLY A 141
LEU A 177
ILE A 142
None
1.07A 3ku1G-5fmrA:
2.1
3ku1G-5fmrA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnx POTATO STI-KUNITZ
BI-FUNCTIONAL
INHIBITOR E3AD_N19D


(Solanum
tuberosum)
PF00197
(Kunitz_legume)
5 LEU A 172
GLY A  34
VAL A  59
PRO A  61
GLY A  30
None
0.87A 3ku1G-5fnxA:
undetectable
3ku1G-5fnxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
5 ASN A  60
GLY A   8
ALA A  68
LEU A  30
ILE A  20
None
1.11A 3ku1G-5fxnA:
undetectable
3ku1G-5fxnA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6j PIERISIN-1

(Pieris rapae)
no annotation 5 LEU A  53
GLY A 147
ASP A 149
GLY A 171
ILE A 172
None
1.19A 3ku1G-5h6jA:
undetectable
3ku1G-5h6jA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum)
PF08801
(Nucleoporin_N)
5 LEU A 562
GLY A 178
ALA A 156
LEU A 232
ILE A 177
None
1.13A 3ku1G-5haxA:
undetectable
3ku1G-5haxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E


(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
5 ASN A 532
ALA A 565
GLY A 484
LEU A 481
ILE A 479
None
1.02A 3ku1G-5ihwA:
undetectable
3ku1G-5ihwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE


(Rhizobium
leguminosarum)
PF00920
(ILVD_EDD)
5 ARG A 289
LEU A 566
ALA A 106
GLY A 137
LEU A  50
None
1.00A 3ku1G-5j84A:
2.0
3ku1G-5j84A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR


(Mus musculus)
no annotation 5 GLY B 216
ASP B 194
GLY B 142
GLY B 196
LEU B 155
None
1.13A 3ku1G-5lhsB:
undetectable
3ku1G-5lhsB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
5 ARG A1034
PRO A 898
ALA A 960
LEU A 971
ILE A 911
None
1.16A 3ku1G-5mqsA:
undetectable
3ku1G-5mqsA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2h I-ONUI_E-HTCRA

(synthetic
construct)
PF00961
(LAGLIDADG_1)
5 LEU A  99
ALA A  19
GLY A  23
LEU A  49
ILE A  56
None
1.12A 3ku1G-5t2hA:
undetectable
3ku1G-5t2hA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE
MDCD


(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa)
PF06833
(MdcE)
PF01039
(Carboxyl_trans)
5 GLY B 182
GLY B 162
GLY A 110
LEU A 115
ILE B 165
None
0.90A 3ku1G-5vipB:
undetectable
3ku1G-5vipB:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
5 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
None
0.75A 3ku1G-5vlhA:
undetectable
3ku1G-5vlhA:
20.60