SIMILAR PATTERNS OF AMINO ACIDS FOR 3KU1_A_SAMA226_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee1 NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Bacillus
subtilis)
PF02540
(NAD_synthase)
5 PRO A 199
ALA A  54
GLY A  55
LEU A  60
ILE A  22
None
0.90A 3ku1A-1ee1A:
2.1
3ku1A-1ee1A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep5 CAPSID PROTEIN C

(Venezuelan
equine
encephalitis
virus)
no annotation 5 GLY B 243
VAL B 255
PRO B 269
ALA B 222
GLY B 221
None
0.92A 3ku1A-1ep5B:
undetectable
3ku1A-1ep5B:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE


(Curvularia
inaequalis)
PF01569
(PAP2)
5 LEU A 555
GLY A 227
PRO A 577
GLY A 346
LEU A  49
None
0.94A 3ku1A-1iduA:
undetectable
3ku1A-1iduA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 LEU A 492
GLY A 569
GLY A 571
LEU A 539
ILE A 554
None
0.98A 3ku1A-1itzA:
2.3
3ku1A-1itzA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A1182
GLY A1158
ALA A1177
GLY A1176
ILE A1265
None
0.92A 3ku1A-1jqbA:
4.1
3ku1A-1jqbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca)
PF00759
(Glyco_hydro_9)
PF00942
(CBM_3)
5 VAL A 364
GLY A 400
ALA A 431
GLY A 432
LEU A 437
None
0.83A 3ku1A-1js4A:
undetectable
3ku1A-1js4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum)
PF00759
(Glyco_hydro_9)
PF00942
(CBM_3)
5 VAL A 361
GLY A 397
ALA A 427
GLY A 428
LEU A 433
None
0.88A 3ku1A-1k72A:
undetectable
3ku1A-1k72A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1


(Neisseria
gonorrhoeae)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
5 VAL A 266
GLY A 269
GLY A 129
LEU A 151
ILE A 132
None
0.86A 3ku1A-1kbvA:
undetectable
3ku1A-1kbvA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20)
PF00704
(Glyco_hydro_18)
5 GLY A 166
GLY A 182
ALA A 177
GLY A 176
LEU A 110
None
0.83A 3ku1A-1kfwA:
undetectable
3ku1A-1kfwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Pectobacterium
carotovorum)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 GLY A 191
ALA A  66
GLY A  67
LEU A  72
ILE A 194
None
0.81A 3ku1A-1khdA:
2.9
3ku1A-1khdA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis)
PF00759
(Glyco_hydro_9)
5 VAL A 347
GLY A 389
ALA A 419
GLY A 420
LEU A 425
None
0.80A 3ku1A-1ks8A:
undetectable
3ku1A-1ks8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF01063
(Aminotran_4)
5 LEU A  61
ASN A 206
GLY A 205
GLY A 148
LEU A 107
None
0.92A 3ku1A-1kt8A:
undetectable
3ku1A-1kt8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN


(Zea mays)
PF00069
(Pkinase)
5 VAL A 162
ALA A 223
GLY A 224
MET A 225
ILE A 137
None
0.95A 3ku1A-1m2pA:
undetectable
3ku1A-1m2pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
5 VAL B 254
GLY B 251
ALA B 230
GLY B 229
ILE B 237
None
0.91A 3ku1A-1mhyB:
undetectable
3ku1A-1mhyB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)


(Ascophyllum
nodosum)
no annotation 5 LEU A 495
GLY A 438
ALA A 426
LEU A 291
ILE A 433
None
0.89A 3ku1A-1qi9A:
undetectable
3ku1A-1qi9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF00291
(PALP)
5 LEU A 234
GLY A 173
PRO A 201
GLY A 177
ILE A  39
None
None
None
PLP  A 413 (-3.8A)
None
0.93A 3ku1A-1ve1A:
5.0
3ku1A-1ve1A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN


(Escherichia
coli)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 GLY A 331
ALA A 339
GLY A 340
LEU A 345
ILE A 330
None
0.97A 3ku1A-1w78A:
2.0
3ku1A-1w78A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii)
PF00710
(Asparaginase)
5 GLY A 213
VAL A 248
GLY A 210
LEU A 207
ILE A 205
None
0.81A 3ku1A-1wlsA:
undetectable
3ku1A-1wlsA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
6 GLY A 252
VAL A 273
GLY A 250
ALA A 104
GLY A 106
ILE A 224
None
1.49A 3ku1A-1wwkA:
6.9
3ku1A-1wwkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)


(Thermus
thermophilus)
PF02347
(GDC-P)
6 GLY B 283
PRO B 252
GLY B 139
ALA B 124
LEU B 288
ILE B 142
None
1.43A 3ku1A-1wytB:
undetectable
3ku1A-1wytB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA


(Mycobacterium
tuberculosis)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
6 ARG A 304
PRO A 233
GLY A 229
ALA A 259
GLY A 258
ILE A 228
None
1.23A 3ku1A-1zj9A:
undetectable
3ku1A-1zj9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1


(Homo sapiens)
PF00102
(Y_phosphatase)
6 GLY A 294
VAL A 289
GLY A 332
MET A 333
LEU A 326
ILE A 155
PO4  A 501 (-4.4A)
None
None
None
None
None
1.36A 3ku1A-2a3kA:
undetectable
3ku1A-2a3kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R


(Homo sapiens)
PF00102
(Y_phosphatase)
6 GLY A 591
VAL A 586
GLY A 629
MET A 630
LEU A 623
ILE A 452
None
1.31A 3ku1A-2a8bA:
undetectable
3ku1A-2a8bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE


(Pseudomonas
aeruginosa)
PF00696
(AA_kinase)
5 LEU A 216
GLY A 186
ALA A 202
GLY A 203
ILE A 134
None
0.91A 3ku1A-2bufA:
3.6
3ku1A-2bufA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5


(Homo sapiens)
PF00102
(Y_phosphatase)
6 GLY A 475
VAL A 470
GLY A 513
MET A 514
LEU A 507
ILE A 335
SCY  A 472 ( 3.6A)
None
None
None
None
None
1.29A 3ku1A-2bv5A:
undetectable
3ku1A-2bv5A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE


(Pyrococcus
horikoshii)
PF00390
(malic)
PF03949
(Malic_M)
5 GLY A 209
ALA A 171
GLY A 172
LEU A 177
ILE A 184
None
0.95A 3ku1A-2dvmA:
2.5
3ku1A-2dvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ARG A 208
GLY A 129
ALA A 171
GLY A 168
ILE A 412
None
0.86A 3ku1A-2e6kA:
3.2
3ku1A-2e6kA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fx5 LIPASE

(Pseudomonas
mendocina)
no annotation 5 GLY A 131
PRO A 149
GLY A 155
ALA A 135
GLY A 136
None
0.89A 3ku1A-2fx5A:
undetectable
3ku1A-2fx5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE


(Xanthomonas
citri)
PF01663
(Phosphodiest)
5 ARG A 243
ALA A 239
GLY A 240
MET A 241
ILE A 252
None
0.93A 3ku1A-2gsnA:
undetectable
3ku1A-2gsnA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtp REGULATOR OF
G-PROTEIN SIGNALING
1


(Homo sapiens)
PF00615
(RGS)
5 GLY C  82
GLY C  87
ALA C  78
LEU C 103
ILE C  99
None
0.95A 3ku1A-2gtpC:
undetectable
3ku1A-2gtpC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE


(Trypanosoma
brucei)
PF00365
(PFK)
5 GLY A 223
VAL A 221
GLY A 412
GLY A 197
ILE A 427
None
0.90A 3ku1A-2higA:
2.1
3ku1A-2higA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE


(Trypanosoma
brucei)
PF00365
(PFK)
5 GLY A 223
VAL A 221
GLY A 412
GLY A 198
ILE A 427
None
0.92A 3ku1A-2higA:
2.1
3ku1A-2higA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iex DIHYDROXYNAPTHOIC
ACID SYNTHETASE


(Geobacillus
kaustophilus)
PF00378
(ECH_1)
5 LEU A 194
GLY A  66
ALA A 114
GLY A 115
ILE A  27
None
0.94A 3ku1A-2iexA:
undetectable
3ku1A-2iexA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3s FILAMIN-A

(Homo sapiens)
PF00630
(Filamin)
5 LEU A2162
PRO A2181
GLY A2237
ALA A2266
GLY A2267
None
0.79A 3ku1A-2j3sA:
undetectable
3ku1A-2j3sA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzj CYANOVIRIN-N HOMOLOG

(Ceratopteris
richardii)
PF08881
(CVNH)
5 GLY A  56
GLY A  42
GLY A  16
LEU A  70
ILE A  41
None
0.90A 3ku1A-2jzjA:
undetectable
3ku1A-2jzjA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfu GNA2132

(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
5 VAL A 401
GLY A 376
ALA A 314
GLY A 315
ILE A 372
None
0.82A 3ku1A-2lfuA:
undetectable
3ku1A-2lfuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
6 LEU A 281
GLY A 237
VAL A 422
GLY A 242
LEU A 449
ILE A 393
None
1.38A 3ku1A-2nlxA:
undetectable
3ku1A-2nlxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE


(Neisseria
meningitidis)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 ARG A 321
VAL A 280
PRO A 283
ALA A 200
GLY A 199
None
0.96A 3ku1A-2olsA:
undetectable
3ku1A-2olsA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE


(Thermus
thermophilus)
PF01370
(Epimerase)
5 GLY A 175
GLY A 299
ALA A 188
GLY A 185
ILE A 300
None
0.96A 3ku1A-2p5uA:
5.0
3ku1A-2p5uA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN


(Enterococcus
faecalis)
PF07859
(Abhydrolase_3)
5 LEU A  48
GLY A 231
GLY A 100
LEU A 109
ILE A 230
None
0.94A 3ku1A-2qruA:
undetectable
3ku1A-2qruA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum)
PF00701
(DHDPS)
5 GLY A 221
ALA A 204
GLY A 205
LEU A 210
ILE A 220
None
0.87A 3ku1A-2r8wA:
undetectable
3ku1A-2r8wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rij PUTATIVE
2,3,4,5-TETRAHYDROPY
RIDINE-2-CARBOXYLATE
N-
SUCCINYLTRANSFERASE


(Campylobacter
jejuni)
PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N)
5 GLY A 252
VAL A 266
GLY A 249
ALA A 233
GLY A 234
None
0.90A 3ku1A-2rijA:
undetectable
3ku1A-2rijA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE


(Mycobacterium
tuberculosis)
PF01255
(Prenyltransf)
6 LEU A 222
GLY A 124
GLY A 127
ALA A 155
LEU A 137
ILE A 129
None
1.32A 3ku1A-2vfwA:
3.1
3ku1A-2vfwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115


(Homo sapiens)
PF04869
(Uso1_p115_head)
5 LEU A 171
GLY A 142
GLY A  80
LEU A  69
ILE A  79
None
0.92A 3ku1A-2w3cA:
undetectable
3ku1A-2w3cA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE


(Nonomuraea
gerenzanensis)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 478
VAL A 383
ALA A 368
GLY A 369
LEU A 400
None
0.96A 3ku1A-2wdwA:
undetectable
3ku1A-2wdwA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
5 VAL A 364
GLY A 400
ALA A 430
GLY A 431
LEU A 436
None
0.92A 3ku1A-2xfgA:
undetectable
3ku1A-2xfgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
5 GLY A 186
GLY A 644
ALA A 673
GLY A 674
ILE A 655
None
0.93A 3ku1A-2xvgA:
undetectable
3ku1A-2xvgA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG


(Aquifex
aeolicus)
PF01134
(GIDA)
PF13932
(GIDA_assoc)
6 LEU A 455
GLY A 389
GLY A 376
GLY A 418
MET A 420
LEU A 424
None
None
FAD  A 618 (-3.3A)
None
None
None
1.49A 3ku1A-2zxhA:
2.9
3ku1A-2zxhA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE


(Plectranthus
scutellarioides)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 241
VAL A 147
ALA A 253
GLY A 252
LEU A 116
None
0.94A 3ku1A-3bazA:
6.6
3ku1A-3bazA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA
HEMOGLOBIN BETA


(Perca
flavescens;
Perca
flavescens)
PF00042
(Globin)
PF00042
(Globin)
5 GLY A  30
VAL A  35
GLY B 124
ALA A  26
GLY A  25
None
0.89A 3ku1A-3bj1A:
undetectable
3ku1A-3bj1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
6 GLY A 209
PRO A 215
ASN A 347
GLY A 206
GLY A 321
LEU A 327
NAD  A 400 ( 4.2A)
None
None
None
None
None
1.20A 3ku1A-3cinA:
undetectable
3ku1A-3cinA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE


(Enterococcus
faecalis)
PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2)
5 GLY A 172
VAL A 189
ALA A 147
GLY A 148
LEU A 151
None
None
None
MG  A 301 ( 4.3A)
None
0.90A 3ku1A-3cj8A:
undetectable
3ku1A-3cj8A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3s L-2,4-DIAMINOBUTYRIC
ACID
ACETYLTRANSFERASE


(Bordetella
parapertussis)
PF00583
(Acetyltransf_1)
5 ARG A 128
GLY A  87
GLY A  56
GLY A  92
LEU A   4
None
0.93A 3ku1A-3d3sA:
undetectable
3ku1A-3d3sA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE


(Streptomyces
coelicolor)
PF07995
(GSDH)
5 GLY A 206
PRO A 265
GLY A 156
ALA A 208
ILE A 176
None
0.95A 3ku1A-3dasA:
undetectable
3ku1A-3dasA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 LEU A 118
VAL A 224
ALA A 182
GLY A 183
ILE A 153
None
None
None
UD1  A4000 ( 4.5A)
None
0.89A 3ku1A-3dj4A:
2.5
3ku1A-3dj4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua)
PF06028
(DUF915)
5 GLY A 105
VAL A 128
GLY A  98
GLY A  11
LEU A  19
None
None
None
SO4  A 256 ( 3.5A)
None
0.81A 3ku1A-3ds8A:
2.0
3ku1A-3ds8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum)
PF07992
(Pyr_redox_2)
5 ARG A 289
GLY A 280
GLY A  14
ALA A 285
ILE A   7
None
0.96A 3ku1A-3fbsA:
3.8
3ku1A-3fbsA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 182
GLY A 158
ALA A 177
GLY A 176
ILE A 265
None
0.95A 3ku1A-3fsrA:
5.7
3ku1A-3fsrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
5 VAL A 284
PRO A 282
ALA A 409
LEU A 415
ILE A 334
None
0.84A 3ku1A-3gcwA:
2.2
3ku1A-3gcwA:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472


(Listeria
monocytogenes)
PF04816
(TrmK)
12 ARG A  15
LEU A  16
GLY A  33
VAL A  57
PRO A  61
ASN A  84
GLY A  85
ALA A 101
GLY A 102
MET A 103
LEU A 107
ILE A 111
None
0.39A 3ku1A-3gnlA:
31.9
3ku1A-3gnlA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472


(Listeria
monocytogenes)
PF04816
(TrmK)
6 LEU A  39
PRO A  61
ALA A 101
MET A 103
LEU A 107
ILE A 111
None
1.49A 3ku1A-3gnlA:
31.9
3ku1A-3gnlA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjp PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG (BCP-4)


(Sulfolobus
solfataricus)
PF00578
(AhpC-TSA)
5 LEU A 108
PRO A 143
GLY A  68
ALA A  39
ILE A  90
None
None
None
CL  A 700 ( 4.6A)
None
0.96A 3ku1A-3hjpA:
undetectable
3ku1A-3hjpA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isl PURINE CATABOLISM
PROTEIN PUCG


(Bacillus
subtilis)
PF00266
(Aminotran_5)
5 GLY A 312
ALA A 383
GLY A 384
LEU A 389
ILE A 396
None
0.95A 3ku1A-3islA:
undetectable
3ku1A-3islA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Lactobacillus
brevis)
PF13407
(Peripla_BP_4)
5 VAL A 148
PRO A 161
GLY A 126
ALA A 312
GLY A 313
None
0.92A 3ku1A-3jy6A:
2.4
3ku1A-3jy6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
5 LEU A1472
GLY A1224
VAL A1229
GLY A1141
LEU A1144
None
None
None
WW2  A 193 (-3.8A)
None
0.95A 3ku1A-3k9bA:
2.9
3ku1A-3k9bA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
11 ARG A   5
GLY A  23
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
None
0.64A 3ku1A-3kr9A:
35.0
3ku1A-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
11 LEU A   6
GLY A  23
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
None
0.50A 3ku1A-3kr9A:
35.0
3ku1A-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
6 LEU A  29
PRO A  51
ALA A  91
MET A  93
LEU A  97
ILE A 101
None
1.47A 3ku1A-3kr9A:
35.0
3ku1A-3kr9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lec NADB-ROSSMANN
SUPERFAMILY PROTEIN


(Streptococcus
agalactiae)
PF04816
(TrmK)
10 ARG A   8
LEU A   9
GLY A  26
VAL A  50
PRO A  54
GLY A  78
GLY A  95
MET A  96
LEU A 100
ILE A 104
None
None
None
None
None
None
None
None
SO4  A 229 ( 4.7A)
None
0.54A 3ku1A-3lecA:
33.0
3ku1A-3lecA:
61.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus)
PF00704
(Glyco_hydro_18)
5 VAL A 224
ALA A 271
GLY A 258
LEU A 209
ILE A 212
None
0.95A 3ku1A-3n11A:
undetectable
3ku1A-3n11A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli;
Escherichia
coli;
Escherichia
coli)
no annotation
no annotation
no annotation
5 LEU N 176
PRO K   3
GLY J   9
ALA K  12
ILE J  13
None
0.92A 3ku1A-3rkoN:
undetectable
3ku1A-3rkoN:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
ulcerans)
PF13561
(adh_short_C2)
5 VAL A  12
ALA A  45
GLY A  46
LEU A  51
ILE A  61
None
0.92A 3ku1A-3svtA:
6.8
3ku1A-3svtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 ARG A 100
GLY A 220
MET A  51
LEU A  55
ILE A 190
PO4  A 324 (-3.8A)
None
PO4  A 323 (-3.8A)
None
None
0.94A 3ku1A-3ts7A:
undetectable
3ku1A-3ts7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus)
PF00480
(ROK)
5 LEU A  88
GLY A  10
GLY A 131
ALA A  64
GLY A  63
None
ANP  A 325 (-3.4A)
ANP  A 325 (-3.0A)
None
None
0.90A 3ku1A-3vglA:
undetectable
3ku1A-3vglA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 GLY A2072
ALA A2021
GLY A2020
LEU A2067
ILE A2046
None
0.92A 3ku1A-3vkgA:
undetectable
3ku1A-3vkgA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B


(Escherichia
coli)
PF00873
(ACR_tran)
5 ARG A 815
LEU A 721
VAL A 612
ALA A 618
GLY A 619
None
0.97A 3ku1A-3w9hA:
undetectable
3ku1A-3w9hA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E


(Rhodococcus
jostii)
PF00890
(FAD_binding_2)
6 LEU A  96
GLY A 469
VAL A 167
GLY A  64
ALA A 467
GLY A 148
None
FAD  A1493 ( 3.1A)
None
ACT  A1491 ( 3.2A)
None
None
1.22A 3ku1A-4at0A:
undetectable
3ku1A-4at0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj8 ZEBAVIDIN

(Danio rerio)
PF01382
(Avidin)
5 VAL A  64
PRO A  62
GLY A  10
LEU A  20
ILE A  52
None
0.90A 3ku1A-4bj8A:
undetectable
3ku1A-4bj8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii)
PF00759
(Glyco_hydro_9)
5 VAL A 384
GLY A 420
ALA A 450
GLY A 451
LEU A 456
None
0.87A 3ku1A-4doeA:
undetectable
3ku1A-4doeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3


(Mycolicibacterium
smegmatis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 LEU A  96
GLY A  50
ALA A  61
GLY A  60
ILE A  10
None
0.98A 3ku1A-4iv6A:
undetectable
3ku1A-4iv6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]


(Synechocystis
sp. PCC 6803)
PF02347
(GDC-P)
6 LEU A 234
GLY A 317
ALA A 173
GLY A 170
LEU A 167
ILE A 352
None
1.35A 3ku1A-4lglA:
4.4
3ku1A-4lglA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II


(Acidothermus
cellulolyticus)
no annotation 6 ARG A  44
VAL A  59
ASN A  63
ALA A 108
GLY A 107
LEU A 101
None
None
EDO  A 805 ( 4.6A)
None
None
None
1.50A 3ku1A-4lgnA:
undetectable
3ku1A-4lgnA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
5 PRO A 194
GLY A 177
GLY A 225
LEU A 202
ILE A 236
None
FAD  A 601 (-3.5A)
None
None
FAD  A 601 (-3.9A)
0.96A 3ku1A-4oalA:
undetectable
3ku1A-4oalA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
5 VAL B 284
PRO B 282
ALA B 409
LEU B 415
ILE B 334
None
0.86A 3ku1A-4ov6B:
undetectable
3ku1A-4ov6B:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Atopobium
parvulum)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 LEU A 333
ASN A 318
GLY A 315
ALA A 367
GLY A 416
None
0.89A 3ku1A-4ovdA:
undetectable
3ku1A-4ovdA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq9 BETA-1,3-GLUCANASE

(Mycobacterium
marinum)
PF00722
(Glyco_hydro_16)
5 VAL A 225
GLY A 141
ALA A 210
GLY A 191
MET A 192
None
0.96A 3ku1A-4pq9A:
undetectable
3ku1A-4pq9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A2905
VAL A2657
ALA A2552
GLY A2551
LEU A2641
None
0.82A 3ku1A-4qyrA:
undetectable
3ku1A-4qyrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN


(Salmonella
enterica)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1)
5 LEU A1038
GLY A 982
ALA A1010
LEU A 988
ILE A 981
None
0.97A 3ku1A-4u48A:
undetectable
3ku1A-4u48A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides)
PF13419
(HAD_2)
5 GLY A 219
ALA A 215
GLY A  96
LEU A 174
ILE A 192
None
0.92A 3ku1A-4uarA:
undetectable
3ku1A-4uarA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02153
(PDH)
5 PRO A 124
GLY A  12
ALA A 135
GLY A 136
ILE A  13
NAP  A 301 (-4.6A)
NAP  A 301 (-3.4A)
None
None
None
0.94A 3ku1A-4wjiA:
2.2
3ku1A-4wjiA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Staphylococcus
aureus)
PF00496
(SBP_bac_5)
5 LEU A  52
VAL A  29
GLY A 154
LEU A 169
ILE A 158
None
0.86A 3ku1A-4xkqA:
undetectable
3ku1A-4xkqA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA


(Pseudomonas
fluorescens)
PF04820
(Trp_halogenase)
6 LEU A  55
GLY A  48
ASN A 315
GLY A  46
GLY A 349
ILE A  45
None
FAD  A 601 (-3.4A)
None
None
FAD  A 601 ( 3.6A)
FAD  A 601 (-3.7A)
1.28A 3ku1A-4z43A:
undetectable
3ku1A-4z43A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris)
PF00759
(Glyco_hydro_9)
5 VAL A 349
GLY A 391
ALA A 421
GLY A 422
LEU A 427
None
0.88A 3ku1A-4zg8A:
undetectable
3ku1A-4zg8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME


(Aster yellows
witches'-broom
phytoplasma)
PF00390
(malic)
PF03949
(Malic_M)
5 ARG A 325
LEU A 328
VAL A  21
GLY A  19
GLY A 100
None
0.95A 3ku1A-5ceeA:
2.4
3ku1A-5ceeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chs RNA-DIRECTED RNA
POLYMERASE L


(Indiana
vesiculovirus)
PF00946
(Mononeg_RNA_pol)
5 PRO A 291
GLY A 271
ALA A 326
GLY A 325
ILE A 274
None
0.96A 3ku1A-5chsA:
undetectable
3ku1A-5chsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE


(Vibrio cholerae)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410)
5 VAL A 177
GLY A 127
ALA A 214
LEU A 138
ILE A 128
None
None
NAD  A 401 (-4.2A)
None
None
0.96A 3ku1A-5dt9A:
undetectable
3ku1A-5dt9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN


(Measles
morbillivirus)
PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT)
5 GLY A 257
ALA A 271
GLY A 272
LEU A 277
ILE A 258
None
0.90A 3ku1A-5e4vA:
undetectable
3ku1A-5e4vA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans)
PF01039
(Carboxyl_trans)
5 GLY A 158
GLY A 197
ALA A 201
GLY A 202
LEU A 207
None
0.98A 3ku1A-5fifA:
2.4
3ku1A-5fifA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
PF00942
(CBM_3)
5 VAL A 376
GLY A 412
ALA A 442
GLY A 443
LEU A 448
None
0.91A 3ku1A-5gy0A:
undetectable
3ku1A-5gy0A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E


(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
6 GLY A 470
ASN A 532
ALA A 565
GLY A 484
LEU A 481
ILE A 479
None
1.32A 3ku1A-5ihwA:
undetectable
3ku1A-5ihwA:
20.89