SIMILAR PATTERNS OF AMINO ACIDS FOR 3KU1_A_SAMA226_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ee1 | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Bacillussubtilis) |
PF02540(NAD_synthase) | 5 | PRO A 199ALA A 54GLY A 55LEU A 60ILE A 22 | None | 0.90A | 3ku1A-1ee1A:2.1 | 3ku1A-1ee1A:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ep5 | CAPSID PROTEIN C (Venezuelanequineencephalitisvirus) |
no annotation | 5 | GLY B 243VAL B 255PRO B 269ALA B 222GLY B 221 | None | 0.92A | 3ku1A-1ep5B:undetectable | 3ku1A-1ep5B:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 5 | LEU A 555GLY A 227PRO A 577GLY A 346LEU A 49 | None | 0.94A | 3ku1A-1iduA:undetectable | 3ku1A-1iduA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 492GLY A 569GLY A 571LEU A 539ILE A 554 | None | 0.98A | 3ku1A-1itzA:2.3 | 3ku1A-1itzA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqb | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A1182GLY A1158ALA A1177GLY A1176ILE A1265 | None | 0.92A | 3ku1A-1jqbA:4.1 | 3ku1A-1jqbA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js4 | ENDO/EXOCELLULASE E4 (Thermobifidafusca) |
PF00759(Glyco_hydro_9)PF00942(CBM_3) | 5 | VAL A 364GLY A 400ALA A 431GLY A 432LEU A 437 | None | 0.83A | 3ku1A-1js4A:undetectable | 3ku1A-1js4A:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k72 | ENDOGLUCANASE 9G ([Clostridium]cellulolyticum) |
PF00759(Glyco_hydro_9)PF00942(CBM_3) | 5 | VAL A 361GLY A 397ALA A 427GLY A 428LEU A 433 | None | 0.88A | 3ku1A-1k72A:undetectable | 3ku1A-1k72A:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbv | MAJOR OUTER MEMBRANEPROTEIN PAN 1 (Neisseriagonorrhoeae) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3) | 5 | VAL A 266GLY A 269GLY A 129LEU A 151ILE A 132 | None | 0.86A | 3ku1A-1kbvA:undetectable | 3ku1A-1kbvA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfw | CHITINASE B (Arthrobactersp. TAD20) |
PF00704(Glyco_hydro_18) | 5 | GLY A 166GLY A 182ALA A 177GLY A 176LEU A 110 | None | 0.83A | 3ku1A-1kfwA:undetectable | 3ku1A-1kfwA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khd | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Pectobacteriumcarotovorum) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | GLY A 191ALA A 66GLY A 67LEU A 72ILE A 194 | None | 0.81A | 3ku1A-1khdA:2.9 | 3ku1A-1khdA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ks8 | ENDO-B-1,4-GLUCANASE (Nasutitermestakasagoensis) |
PF00759(Glyco_hydro_9) | 5 | VAL A 347GLY A 389ALA A 419GLY A 420LEU A 425 | None | 0.80A | 3ku1A-1ks8A:undetectable | 3ku1A-1ks8A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kt8 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF01063(Aminotran_4) | 5 | LEU A 61ASN A 206GLY A 205GLY A 148LEU A 107 | None | 0.92A | 3ku1A-1kt8A:undetectable | 3ku1A-1kt8A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2p | CASEIN KINASE II,ALPHA CHAIN (Zea mays) |
PF00069(Pkinase) | 5 | VAL A 162ALA A 223GLY A 224MET A 225ILE A 137 | None | 0.95A | 3ku1A-1m2pA:undetectable | 3ku1A-1m2pA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhy | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 5 | VAL B 254GLY B 251ALA B 230GLY B 229ILE B 237 | None | 0.91A | 3ku1A-1mhyB:undetectable | 3ku1A-1mhyB:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qi9 | PROTEIN (VANADIUMBROMOPEROXIDASE) (Ascophyllumnodosum) |
no annotation | 5 | LEU A 495GLY A 438ALA A 426LEU A 291ILE A 433 | None | 0.89A | 3ku1A-1qi9A:undetectable | 3ku1A-1qi9A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve1 | O-ACETYLSERINESULFHYDRYLASE (Thermusthermophilus) |
PF00291(PALP) | 5 | LEU A 234GLY A 173PRO A 201GLY A 177ILE A 39 | NoneNoneNonePLP A 413 (-3.8A)None | 0.93A | 3ku1A-1ve1A:5.0 | 3ku1A-1ve1A:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w78 | FOLC BIFUNCTIONALPROTEIN (Escherichiacoli) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | GLY A 331ALA A 339GLY A 340LEU A 345ILE A 330 | None | 0.97A | 3ku1A-1w78A:2.0 | 3ku1A-1w78A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wls | L-ASPARAGINASE (Pyrococcushorikoshii) |
PF00710(Asparaginase) | 5 | GLY A 213VAL A 248GLY A 210LEU A 207ILE A 205 | None | 0.81A | 3ku1A-1wlsA:undetectable | 3ku1A-1wlsA:25.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wwk | PHOSPHOGLYCERATEDEHYDROGENASE (Pyrococcushorikoshii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 6 | GLY A 252VAL A 273GLY A 250ALA A 104GLY A 106ILE A 224 | None | 1.49A | 3ku1A-1wwkA:6.9 | 3ku1A-1wwkA:26.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASESUBUNIT 2(P-PROTEIN) (Thermusthermophilus) |
PF02347(GDC-P) | 6 | GLY B 283PRO B 252GLY B 139ALA B 124LEU B 288ILE B 142 | None | 1.43A | 3ku1A-1wytB:undetectable | 3ku1A-1wytB:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zj9 | PROBABLEFERREDOXIN-DEPENDENTNITRITE REDUCTASENIRA (Mycobacteriumtuberculosis) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 6 | ARG A 304PRO A 233GLY A 229ALA A 259GLY A 258ILE A 228 | None | 1.23A | 3ku1A-1zj9A:undetectable | 3ku1A-1zj9A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3k | PROTEIN TYROSINEPHOSPHATASE,NON-RECEPTOR TYPE 7,ISOFORM 1 (Homo sapiens) |
PF00102(Y_phosphatase) | 6 | GLY A 294VAL A 289GLY A 332MET A 333LEU A 326ILE A 155 | PO4 A 501 (-4.4A)NoneNoneNoneNoneNone | 1.36A | 3ku1A-2a3kA:undetectable | 3ku1A-2a3kA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8b | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE R (Homo sapiens) |
PF00102(Y_phosphatase) | 6 | GLY A 591VAL A 586GLY A 629MET A 630LEU A 623ILE A 452 | None | 1.31A | 3ku1A-2a8bA:undetectable | 3ku1A-2a8bA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buf | ACETYLGLUTAMATEKINASE (Pseudomonasaeruginosa) |
PF00696(AA_kinase) | 5 | LEU A 216GLY A 186ALA A 202GLY A 203ILE A 134 | None | 0.91A | 3ku1A-2bufA:3.6 | 3ku1A-2bufA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bv5 | TYROSINE-PROTEINPHOSPHATASE,NON-RECEPTOR TYPE 5 (Homo sapiens) |
PF00102(Y_phosphatase) | 6 | GLY A 475VAL A 470GLY A 513MET A 514LEU A 507ILE A 335 | SCY A 472 ( 3.6A)NoneNoneNoneNoneNone | 1.29A | 3ku1A-2bv5A:undetectable | 3ku1A-2bv5A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dvm | 439AA LONGHYPOTHETICAL MALATEOXIDOREDUCTASE (Pyrococcushorikoshii) |
PF00390(malic)PF03949(Malic_M) | 5 | GLY A 209ALA A 171GLY A 172LEU A 177ILE A 184 | None | 0.95A | 3ku1A-2dvmA:2.5 | 3ku1A-2dvmA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e6k | TRANSKETOLASE (Thermusthermophilus) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ARG A 208GLY A 129ALA A 171GLY A 168ILE A 412 | None | 0.86A | 3ku1A-2e6kA:3.2 | 3ku1A-2e6kA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fx5 | LIPASE (Pseudomonasmendocina) |
no annotation | 5 | GLY A 131PRO A 149GLY A 155ALA A 135GLY A 136 | None | 0.89A | 3ku1A-2fx5A:undetectable | 3ku1A-2fx5A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsn | PHOSPHODIESTERASE-NUCLEOTIDEPYROPHOSPHATASE (Xanthomonascitri) |
PF01663(Phosphodiest) | 5 | ARG A 243ALA A 239GLY A 240MET A 241ILE A 252 | None | 0.93A | 3ku1A-2gsnA:undetectable | 3ku1A-2gsnA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gtp | REGULATOR OFG-PROTEIN SIGNALING1 (Homo sapiens) |
PF00615(RGS) | 5 | GLY C 82GLY C 87ALA C 78LEU C 103ILE C 99 | None | 0.95A | 3ku1A-2gtpC:undetectable | 3ku1A-2gtpC:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hig | 6-PHOSPHO-1-FRUCTOKINASE (Trypanosomabrucei) |
PF00365(PFK) | 5 | GLY A 223VAL A 221GLY A 412GLY A 197ILE A 427 | None | 0.90A | 3ku1A-2higA:2.1 | 3ku1A-2higA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hig | 6-PHOSPHO-1-FRUCTOKINASE (Trypanosomabrucei) |
PF00365(PFK) | 5 | GLY A 223VAL A 221GLY A 412GLY A 198ILE A 427 | None | 0.92A | 3ku1A-2higA:2.1 | 3ku1A-2higA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iex | DIHYDROXYNAPTHOICACID SYNTHETASE (Geobacilluskaustophilus) |
PF00378(ECH_1) | 5 | LEU A 194GLY A 66ALA A 114GLY A 115ILE A 27 | None | 0.94A | 3ku1A-2iexA:undetectable | 3ku1A-2iexA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3s | FILAMIN-A (Homo sapiens) |
PF00630(Filamin) | 5 | LEU A2162PRO A2181GLY A2237ALA A2266GLY A2267 | None | 0.79A | 3ku1A-2j3sA:undetectable | 3ku1A-2j3sA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzj | CYANOVIRIN-N HOMOLOG (Ceratopterisrichardii) |
PF08881(CVNH) | 5 | GLY A 56GLY A 42GLY A 16LEU A 70ILE A 41 | None | 0.90A | 3ku1A-2jzjA:undetectable | 3ku1A-2jzjA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lfu | GNA2132 (Neisseriameningitidis) |
PF01298(TbpB_B_D) | 5 | VAL A 401GLY A 376ALA A 314GLY A 315ILE A 372 | None | 0.82A | 3ku1A-2lfuA:undetectable | 3ku1A-2lfuA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nlx | XYLULOSE KINASE (Escherichiacoli) |
PF00370(FGGY_N)PF02782(FGGY_C) | 6 | LEU A 281GLY A 237VAL A 422GLY A 242LEU A 449ILE A 393 | None | 1.38A | 3ku1A-2nlxA:undetectable | 3ku1A-2nlxA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ols | PHOSPHOENOLPYRUVATESYNTHASE (Neisseriameningitidis) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | ARG A 321VAL A 280PRO A 283ALA A 200GLY A 199 | None | 0.96A | 3ku1A-2olsA:undetectable | 3ku1A-2olsA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p5u | UDP-GLUCOSE4-EPIMERASE (Thermusthermophilus) |
PF01370(Epimerase) | 5 | GLY A 175GLY A 299ALA A 188GLY A 185ILE A 300 | None | 0.96A | 3ku1A-2p5uA:5.0 | 3ku1A-2p5uA:24.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qru | UNCHARACTERIZEDPROTEIN (Enterococcusfaecalis) |
PF07859(Abhydrolase_3) | 5 | LEU A 48GLY A 231GLY A 100LEU A 109ILE A 230 | None | 0.94A | 3ku1A-2qruA:undetectable | 3ku1A-2qruA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r8w | AGR_C_1641P (Agrobacteriumfabrum) |
PF00701(DHDPS) | 5 | GLY A 221ALA A 204GLY A 205LEU A 210ILE A 220 | None | 0.87A | 3ku1A-2r8wA:undetectable | 3ku1A-2r8wA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rij | PUTATIVE2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATEN-SUCCINYLTRANSFERASE (Campylobacterjejuni) |
PF14602(Hexapep_2)PF14789(THDPS_M)PF14790(THDPS_N) | 5 | GLY A 252VAL A 266GLY A 249ALA A 233GLY A 234 | None | 0.90A | 3ku1A-2rijA:undetectable | 3ku1A-2rijA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vfw | SHORT-CHAINZ-ISOPRENYLDIPHOSPHATESYNTHETASE (Mycobacteriumtuberculosis) |
PF01255(Prenyltransf) | 6 | LEU A 222GLY A 124GLY A 127ALA A 155LEU A 137ILE A 129 | None | 1.32A | 3ku1A-2vfwA:3.1 | 3ku1A-2vfwA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3c | GENERAL VESICULARTRANSPORT FACTORP115 (Homo sapiens) |
PF04869(Uso1_p115_head) | 5 | LEU A 171GLY A 142GLY A 80LEU A 69ILE A 79 | None | 0.92A | 3ku1A-2w3cA:undetectable | 3ku1A-2w3cA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wdw | PUTATIVE HEXOSEOXIDASE (Nonomuraeagerenzanensis) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | LEU A 478VAL A 383ALA A 368GLY A 369LEU A 400 | None | 0.96A | 3ku1A-2wdwA:undetectable | 3ku1A-2wdwA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfg | ENDOGLUCANASE 1 (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9) | 5 | VAL A 364GLY A 400ALA A 430GLY A 431LEU A 436 | None | 0.92A | 3ku1A-2xfgA:undetectable | 3ku1A-2xfgA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 5 | GLY A 186GLY A 644ALA A 673GLY A 674ILE A 655 | None | 0.93A | 3ku1A-2xvgA:undetectable | 3ku1A-2xvgA:12.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zxh | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME MNMG (Aquifexaeolicus) |
PF01134(GIDA)PF13932(GIDA_assoc) | 6 | LEU A 455GLY A 389GLY A 376GLY A 418MET A 420LEU A 424 | NoneNoneFAD A 618 (-3.3A)NoneNoneNone | 1.49A | 3ku1A-2zxhA:2.9 | 3ku1A-2zxhA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3baz | HYDROXYPHENYLPYRUVATE REDUCTASE (Plectranthusscutellarioides) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 241VAL A 147ALA A 253GLY A 252LEU A 116 | None | 0.94A | 3ku1A-3bazA:6.6 | 3ku1A-3bazA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bj1 | HEMOGLOBIN ALPHAHEMOGLOBIN BETA (Percaflavescens;Percaflavescens) |
PF00042(Globin)PF00042(Globin) | 5 | GLY A 30VAL A 35GLY B 124ALA A 26GLY A 25 | None | 0.89A | 3ku1A-3bj1A:undetectable | 3ku1A-3bj1A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 6 | GLY A 209PRO A 215ASN A 347GLY A 206GLY A 321LEU A 327 | NAD A 400 ( 4.2A)NoneNoneNoneNoneNone | 1.20A | 3ku1A-3cinA:undetectable | 3ku1A-3cinA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cj8 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-ACETYLTRANSFERASE (Enterococcusfaecalis) |
PF00132(Hexapep)PF08503(DapH_N)PF14602(Hexapep_2) | 5 | GLY A 172VAL A 189ALA A 147GLY A 148LEU A 151 | NoneNoneNone MG A 301 ( 4.3A)None | 0.90A | 3ku1A-3cj8A:undetectable | 3ku1A-3cj8A:25.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3s | L-2,4-DIAMINOBUTYRICACIDACETYLTRANSFERASE (Bordetellaparapertussis) |
PF00583(Acetyltransf_1) | 5 | ARG A 128GLY A 87GLY A 56GLY A 92LEU A 4 | None | 0.93A | 3ku1A-3d3sA:undetectable | 3ku1A-3d3sA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3das | PUTATIVEOXIDOREDUCTASE (Streptomycescoelicolor) |
PF07995(GSDH) | 5 | GLY A 206PRO A 265GLY A 156ALA A 208ILE A 176 | None | 0.95A | 3ku1A-3dasA:undetectable | 3ku1A-3dasA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dj4 | BIFUNCTIONAL PROTEINGLMU (Mycobacteriumtuberculosis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | LEU A 118VAL A 224ALA A 182GLY A 183ILE A 153 | NoneNoneNoneUD1 A4000 ( 4.5A)None | 0.89A | 3ku1A-3dj4A:2.5 | 3ku1A-3dj4A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ds8 | LIN2722 PROTEIN (Listeriainnocua) |
PF06028(DUF915) | 5 | GLY A 105VAL A 128GLY A 98GLY A 11LEU A 19 | NoneNoneNoneSO4 A 256 ( 3.5A)None | 0.81A | 3ku1A-3ds8A:2.0 | 3ku1A-3ds8A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbs | OXIDOREDUCTASE (Agrobacteriumfabrum) |
PF07992(Pyr_redox_2) | 5 | ARG A 289GLY A 280GLY A 14ALA A 285ILE A 7 | None | 0.96A | 3ku1A-3fbsA:3.8 | 3ku1A-3fbsA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsr | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 182GLY A 158ALA A 177GLY A 176ILE A 265 | None | 0.95A | 3ku1A-3fsrA:5.7 | 3ku1A-3fsrA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 5 | VAL A 284PRO A 282ALA A 409LEU A 415ILE A 334 | None | 0.84A | 3ku1A-3gcwA:2.2 | 3ku1A-3gcwA:18.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gnl | UNCHARACTERIZEDPROTEIN, DUF633,LMOF2365_1472 (Listeriamonocytogenes) |
PF04816(TrmK) | 12 | ARG A 15LEU A 16GLY A 33VAL A 57PRO A 61ASN A 84GLY A 85ALA A 101GLY A 102MET A 103LEU A 107ILE A 111 | None | 0.39A | 3ku1A-3gnlA:31.9 | 3ku1A-3gnlA:42.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gnl | UNCHARACTERIZEDPROTEIN, DUF633,LMOF2365_1472 (Listeriamonocytogenes) |
PF04816(TrmK) | 6 | LEU A 39PRO A 61ALA A 101MET A 103LEU A 107ILE A 111 | None | 1.49A | 3ku1A-3gnlA:31.9 | 3ku1A-3gnlA:42.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjp | PEROXIREDOXIN,BACTERIOFERRITINCOMIGRATORY PROTEINHOMOLOG (BCP-4) (Sulfolobussolfataricus) |
PF00578(AhpC-TSA) | 5 | LEU A 108PRO A 143GLY A 68ALA A 39ILE A 90 | NoneNoneNone CL A 700 ( 4.6A)None | 0.96A | 3ku1A-3hjpA:undetectable | 3ku1A-3hjpA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3isl | PURINE CATABOLISMPROTEIN PUCG (Bacillussubtilis) |
PF00266(Aminotran_5) | 5 | GLY A 312ALA A 383GLY A 384LEU A 389ILE A 396 | None | 0.95A | 3ku1A-3islA:undetectable | 3ku1A-3islA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jy6 | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Lactobacillusbrevis) |
PF13407(Peripla_BP_4) | 5 | VAL A 148PRO A 161GLY A 126ALA A 312GLY A 313 | None | 0.92A | 3ku1A-3jy6A:2.4 | 3ku1A-3jy6A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 5 | LEU A1472GLY A1224VAL A1229GLY A1141LEU A1144 | NoneNoneNoneWW2 A 193 (-3.8A)None | 0.95A | 3ku1A-3k9bA:2.9 | 3ku1A-3k9bA:19.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kr9 | SAM-DEPENDENTMETHYLTRANSFERASE (Streptococcuspneumoniae) |
PF04816(TrmK) | 11 | ARG A 5GLY A 23VAL A 47PRO A 51ASN A 74GLY A 75ALA A 91GLY A 92MET A 93LEU A 97ILE A 101 | None | 0.64A | 3ku1A-3kr9A:35.0 | 3ku1A-3kr9A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kr9 | SAM-DEPENDENTMETHYLTRANSFERASE (Streptococcuspneumoniae) |
PF04816(TrmK) | 11 | LEU A 6GLY A 23VAL A 47PRO A 51ASN A 74GLY A 75ALA A 91GLY A 92MET A 93LEU A 97ILE A 101 | None | 0.50A | 3ku1A-3kr9A:35.0 | 3ku1A-3kr9A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kr9 | SAM-DEPENDENTMETHYLTRANSFERASE (Streptococcuspneumoniae) |
PF04816(TrmK) | 6 | LEU A 29PRO A 51ALA A 91MET A 93LEU A 97ILE A 101 | None | 1.47A | 3ku1A-3kr9A:35.0 | 3ku1A-3kr9A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lec | NADB-ROSSMANNSUPERFAMILY PROTEIN (Streptococcusagalactiae) |
PF04816(TrmK) | 10 | ARG A 8LEU A 9GLY A 26VAL A 50PRO A 54GLY A 78GLY A 95MET A 96LEU A 100ILE A 104 | NoneNoneNoneNoneNoneNoneNoneNoneSO4 A 229 ( 4.7A)None | 0.54A | 3ku1A-3lecA:33.0 | 3ku1A-3lecA:61.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n11 | CHITINASE A (Bacillus cereus) |
PF00704(Glyco_hydro_18) | 5 | VAL A 224ALA A 271GLY A 258LEU A 209ILE A 212 | None | 0.95A | 3ku1A-3n11A:undetectable | 3ku1A-3n11A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT JNADH-QUINONEOXIDOREDUCTASESUBUNIT KNADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli;Escherichiacoli;Escherichiacoli) |
no annotationno annotationno annotation | 5 | LEU N 176PRO K 3GLY J 9ALA K 12ILE J 13 | None | 0.92A | 3ku1A-3rkoN:undetectable | 3ku1A-3rkoN:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3svt | SHORT-CHAIN TYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumulcerans) |
PF13561(adh_short_C2) | 5 | VAL A 12ALA A 45GLY A 46LEU A 51ILE A 61 | None | 0.92A | 3ku1A-3svtA:6.8 | 3ku1A-3svtA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ts7 | GERANYLTRANSTRANSFERASE (Methylococcuscapsulatus) |
PF00348(polyprenyl_synt) | 5 | ARG A 100GLY A 220MET A 51LEU A 55ILE A 190 | PO4 A 324 (-3.8A)NonePO4 A 323 (-3.8A)NoneNone | 0.94A | 3ku1A-3ts7A:undetectable | 3ku1A-3ts7A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgl | GLUCOKINASE (Streptomycesgriseus) |
PF00480(ROK) | 5 | LEU A 88GLY A 10GLY A 131ALA A 64GLY A 63 | NoneANP A 325 (-3.4A)ANP A 325 (-3.0A)NoneNone | 0.90A | 3ku1A-3vglA:undetectable | 3ku1A-3vglA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vkg | DYNEIN HEAVY CHAIN,CYTOPLASMIC (Dictyosteliumdiscoideum) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | GLY A2072ALA A2021GLY A2020LEU A2067ILE A2046 | None | 0.92A | 3ku1A-3vkgA:undetectable | 3ku1A-3vkgA:5.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9h | ACRIFLAVINERESISTANCE PROTEIN B (Escherichiacoli) |
PF00873(ACR_tran) | 5 | ARG A 815LEU A 721VAL A 612ALA A 618GLY A 619 | None | 0.97A | 3ku1A-3w9hA:undetectable | 3ku1A-3w9hA:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4at0 | 3-KETOSTEROID-DELTA4-5ALPHA-DEHYDROGENASE (Rhodococcusjostii) |
PF00890(FAD_binding_2) | 6 | LEU A 96GLY A 469VAL A 167GLY A 64ALA A 467GLY A 148 | NoneFAD A1493 ( 3.1A)NoneACT A1491 ( 3.2A)NoneNone | 1.22A | 3ku1A-4at0A:undetectable | 3ku1A-4at0A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj8 | ZEBAVIDIN (Danio rerio) |
PF01382(Avidin) | 5 | VAL A 64PRO A 62GLY A 10LEU A 20ILE A 52 | None | 0.90A | 3ku1A-4bj8A:undetectable | 3ku1A-4bj8A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doe | 1,4-BETA-GLUCANASE (Caldicellulosiruptorbescii) |
PF00759(Glyco_hydro_9) | 5 | VAL A 384GLY A 420ALA A 450GLY A 451LEU A 456 | None | 0.87A | 3ku1A-4doeA:undetectable | 3ku1A-4doeA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv6 | ACYL-COADEHYDROGENASE FADE3 (Mycolicibacteriumsmegmatis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | LEU A 96GLY A 50ALA A 61GLY A 60ILE A 10 | None | 0.98A | 3ku1A-4iv6A:undetectable | 3ku1A-4iv6A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgl | GLYCINEDEHYDROGENASE[DECARBOXYLATING] (Synechocystissp. PCC 6803) |
PF02347(GDC-P) | 6 | LEU A 234GLY A 317ALA A 173GLY A 170LEU A 167ILE A 352 | None | 1.35A | 3ku1A-4lglA:4.4 | 3ku1A-4lglA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgn | CELLULOSE-BINDING,FAMILY II (Acidothermuscellulolyticus) |
no annotation | 6 | ARG A 44VAL A 59ASN A 63ALA A 108GLY A 107LEU A 101 | NoneNoneEDO A 805 ( 4.6A)NoneNoneNone | 1.50A | 3ku1A-4lgnA:undetectable | 3ku1A-4lgnA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oal | CYTOKININDEHYDROGENASE 4 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 5 | PRO A 194GLY A 177GLY A 225LEU A 202ILE A 236 | NoneFAD A 601 (-3.5A)NoneNoneFAD A 601 (-3.9A) | 0.96A | 3ku1A-4oalA:undetectable | 3ku1A-4oalA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov6 | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 5 | VAL B 284PRO B 282ALA B 409LEU B 415ILE B 334 | None | 0.86A | 3ku1A-4ov6B:undetectable | 3ku1A-4ov6B:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovd | PEPTIDOGLYCANGLYCOSYLTRANSFERASE (Atopobiumparvulum) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | LEU A 333ASN A 318GLY A 315ALA A 367GLY A 416 | None | 0.89A | 3ku1A-4ovdA:undetectable | 3ku1A-4ovdA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pq9 | BETA-1,3-GLUCANASE (Mycobacteriummarinum) |
PF00722(Glyco_hydro_16) | 5 | VAL A 225GLY A 141ALA A 210GLY A 191MET A 192 | None | 0.96A | 3ku1A-4pq9A:undetectable | 3ku1A-4pq9A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyr | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A2905VAL A2657ALA A2552GLY A2551LEU A2641 | None | 0.82A | 3ku1A-4qyrA:undetectable | 3ku1A-4qyrA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u48 | PUTATIVE INNERMEMBRANE LIPOPROTEIN (Salmonellaenterica) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF10569(Thiol-ester_cl)PF11974(MG1) | 5 | LEU A1038GLY A 982ALA A1010LEU A 988ILE A 981 | None | 0.97A | 3ku1A-4u48A:undetectable | 3ku1A-4u48A:9.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uar | PROTEIN CBBY (Rhodobactersphaeroides) |
PF13419(HAD_2) | 5 | GLY A 219ALA A 215GLY A 96LEU A 174ILE A 192 | None | 0.92A | 3ku1A-4uarA:undetectable | 3ku1A-4uarA:24.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wji | PUTATIVECYCLOHEXADIENYLDEHYDROGENASE ANDADH PREPHENATEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF02153(PDH) | 5 | PRO A 124GLY A 12ALA A 135GLY A 136ILE A 13 | NAP A 301 (-4.6A)NAP A 301 (-3.4A)NoneNoneNone | 0.94A | 3ku1A-4wjiA:2.2 | 3ku1A-4wjiA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkq | NICKEL ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Staphylococcusaureus) |
PF00496(SBP_bac_5) | 5 | LEU A 52VAL A 29GLY A 154LEU A 169ILE A 158 | None | 0.86A | 3ku1A-4xkqA:undetectable | 3ku1A-4xkqA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z43 | FLAVIN-DEPENDENTTRYPTOPHANHALOGENASE PRNA (Pseudomonasfluorescens) |
PF04820(Trp_halogenase) | 6 | LEU A 55GLY A 48ASN A 315GLY A 46GLY A 349ILE A 45 | NoneFAD A 601 (-3.4A)NoneNoneFAD A 601 ( 3.6A)FAD A 601 (-3.7A) | 1.28A | 3ku1A-4z43A:undetectable | 3ku1A-4z43A:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg8 | ENDOGLUCANASE (Perinereisbrevicirris) |
PF00759(Glyco_hydro_9) | 5 | VAL A 349GLY A 391ALA A 421GLY A 422LEU A 427 | None | 0.88A | 3ku1A-4zg8A:undetectable | 3ku1A-4zg8A:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cee | NAD-DEPENDENT MALICENZYME (Aster yellowswitches'-broomphytoplasma) |
PF00390(malic)PF03949(Malic_M) | 5 | ARG A 325LEU A 328VAL A 21GLY A 19GLY A 100 | None | 0.95A | 3ku1A-5ceeA:2.4 | 3ku1A-5ceeA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chs | RNA-DIRECTED RNAPOLYMERASE L (Indianavesiculovirus) |
PF00946(Mononeg_RNA_pol) | 5 | PRO A 291GLY A 271ALA A 326GLY A 325ILE A 274 | None | 0.96A | 3ku1A-5chsA:undetectable | 3ku1A-5chsA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dt9 | ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE (Vibrio cholerae) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C)PF11890(DUF3410) | 5 | VAL A 177GLY A 127ALA A 214LEU A 138ILE A 128 | NoneNoneNAD A 401 (-4.2A)NoneNone | 0.96A | 3ku1A-5dt9A:undetectable | 3ku1A-5dt9A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4v | NUCLEOPROTEIN,PHOSPHOPROTEIN (Measlesmorbillivirus) |
PF00973(Paramyxo_ncap)PF13825(Paramyxo_PNT) | 5 | GLY A 257ALA A 271GLY A 272LEU A 277ILE A 258 | None | 0.90A | 3ku1A-5e4vA:undetectable | 3ku1A-5e4vA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fif | CARBOXYLASE (Deinococcusradiodurans) |
PF01039(Carboxyl_trans) | 5 | GLY A 158GLY A 197ALA A 201GLY A 202LEU A 207 | None | 0.98A | 3ku1A-5fifA:2.4 | 3ku1A-5fifA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gy0 | GLUCANASE (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF00942(CBM_3) | 5 | VAL A 376GLY A 412ALA A 442GLY A 443LEU A 448 | None | 0.91A | 3ku1A-5gy0A:undetectable | 3ku1A-5gy0A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihw | SERINE-ASPARTATEREPEAT-CONTAININGPROTEIN E (Staphylococcusaureus) |
PF10425(SdrG_C_C) | 6 | GLY A 470ASN A 532ALA A 565GLY A 484LEU A 481ILE A 479 | None | 1.32A | 3ku1A-5ihwA:undetectable | 3ku1A-5ihwA:20.89 |