SIMILAR PATTERNS OF AMINO ACIDS FOR 3KPD_B_SAMB1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN


(Pyrococcus
furiosus)
PF13416
(SBP_bac_8)
5 ASP A 319
VAL A 244
ILE A 121
ASN A 233
ILE A 232
None
1.19A 3kpdB-1eljA:
0.0
3kpdB-1eljA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE


(Escherichia
coli)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 285
THR A 279
VAL A 277
ASN A 269
ILE A 270
None
None
None
None
FAD  A 451 (-4.4A)
1.12A 3kpdB-1geuA:
undetectable
3kpdB-1geuA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001


(Methanothermobacter
thermautotrophicus)
PF02598
(Methyltrn_RNA_3)
5 ILE A  57
THR A  15
VAL A  28
ILE A  31
ILE A  10
None
1.17A 3kpdB-1k3rA:
0.0
3kpdB-1k3rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mab PROTEIN (F1-ATPASE
BETA CHAIN)


(Rattus
norvegicus)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
5 ILE B 108
THR B  90
THR B 110
ILE B  84
PRO B 101
None
1.11A 3kpdB-1mabB:
undetectable
3kpdB-1mabB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugh PROTEIN (URACIL-DNA
GLYCOSYLASE
INHIBITOR)


(Bacillus phage
PBS2)
no annotation 5 ILE I  41
THR I  59
VAL I  29
ILE I  33
PRO I  37
None
1.19A 3kpdB-1ughI:
undetectable
3kpdB-1ughI:
24.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xkf HYPOTHETICAL PROTEIN
RV2626C


(Mycobacterium
tuberculosis)
PF00571
(CBS)
6 ILE A 113
THR A 115
ASP A 118
VAL A  12
ILE A  33
PRO A  37
None
0.98A 3kpdB-1xkfA:
16.0
3kpdB-1xkfA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE


(Arabidopsis
thaliana)
PF13561
(adh_short_C2)
6 ILE A  41
THR A  43
VAL A  31
ILE A  30
ASN A  98
ILE A  97
None
1.19A 3kpdB-1xq1A:
undetectable
3kpdB-1xq1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv7 P-30 PROTEIN

(Rana pipiens)
PF00074
(RnaseA)
5 ILE A  47
THR A  59
VAL A  88
ILE A  37
PRO A  95
None
1.14A 3kpdB-1yv7A:
undetectable
3kpdB-1yv7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57


(Trypanosoma
brucei)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc)
5 VAL A 323
ILE A 326
ILE A 281
SER A 278
PRO A 422
None
1.16A 3kpdB-2b4vA:
undetectable
3kpdB-2b4vA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN


(Thermus
thermophilus)
PF00496
(SBP_bac_5)
5 ILE A 331
THR A 327
ILE A 306
ASN A 309
ILE A 308
None
1.19A 3kpdB-2d5wA:
undetectable
3kpdB-2d5wA:
12.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ef7 HYPOTHETICAL PROTEIN
ST2348


(Sulfurisphaera
tokodaii)
PF00571
(CBS)
5 ILE A  49
ASP A  54
THR A  74
ILE A  98
PRO A 102
None
1.10A 3kpdB-2ef7A:
14.0
3kpdB-2ef7A:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ef7 HYPOTHETICAL PROTEIN
ST2348


(Sulfurisphaera
tokodaii)
PF00571
(CBS)
5 ILE A  49
THR A  51
ASP A  54
THR A  74
ILE A  98
None
0.59A 3kpdB-2ef7A:
14.0
3kpdB-2ef7A:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ef7 HYPOTHETICAL PROTEIN
ST2348


(Sulfurisphaera
tokodaii)
PF00571
(CBS)
5 ILE A  49
THR A  51
LYS A  57
THR A  74
ILE A  98
None
1.04A 3kpdB-2ef7A:
14.0
3kpdB-2ef7A:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7i COMPLEMENT FACTOR H

(Homo sapiens)
PF00084
(Sushi)
5 ILE A1120
THR A1121
VAL A1134
ILE A1150
PRO A1112
None
1.18A 3kpdB-2g7iA:
undetectable
3kpdB-2g7iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mam AT-RICH INTERACTIVE
DOMAIN-CONTAINING
PROTEIN 4A


(Homo sapiens)
no annotation 5 THR A  65
VAL A  63
ILE A  62
ILE A  76
SER A  78
None
1.18A 3kpdB-2mamA:
undetectable
3kpdB-2mamA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE


(Vibrio cholerae)
PF00571
(CBS)
6 ILE A 139
THR A 141
ASP A 144
THR A  28
ILE A  52
PRO A  56
None
PO4  A   1 (-3.0A)
None
None
PO4  A   1 (-4.4A)
None
0.78A 3kpdB-2o16A:
17.5
3kpdB-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I


(Schizosaccharomyces
pombe)
no annotation 7 ILE G 303
ASP G 308
THR G 191
ASN G 215
ILE G 216
SER G 217
PRO G 220
AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
None
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
AMP  G 401 (-4.7A)
0.90A 3kpdB-2ooxG:
11.7
3kpdB-2ooxG:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oux MAGNESIUM
TRANSPORTER


(Enterococcus
faecalis)
PF00571
(CBS)
PF03448
(MgtE_N)
5 VAL A 155
ILE A 202
ASN A 207
ILE A 188
SER A 189
None
1.15A 3kpdB-2ouxA:
14.9
3kpdB-2ouxA:
18.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
6 ILE A  54
THR A  56
VAL A  83
ILE A  84
ILE A 109
PRO A 113
None
0.68A 3kpdB-2p9mA:
17.5
3kpdB-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A 124
ASP A 129
THR A  15
ILE A  39
PRO A  43
None
1.03A 3kpdB-2p9mA:
17.5
3kpdB-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
7 ILE A 124
ASP A 129
THR A  15
VAL A  18
ILE A  19
SER A  40
PRO A  43
None
0.77A 3kpdB-2p9mA:
17.5
3kpdB-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
7 ILE A 124
THR A  15
VAL A  18
ILE A  19
ILE A  39
SER A  40
PRO A  43
None
0.83A 3kpdB-2p9mA:
17.5
3kpdB-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 THR A  56
ASP A  59
ILE A  84
ILE A 109
PRO A 113
None
1.05A 3kpdB-2p9mA:
17.5
3kpdB-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
6 THR A  56
THR A  80
VAL A  83
ILE A  84
ILE A 109
PRO A 113
None
0.76A 3kpdB-2p9mA:
17.5
3kpdB-2p9mA:
37.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1d 2-KETO-3-DEOXY-D-ARA
BINONATE DEHYDRATASE


(Sulfolobus
solfataricus)
PF01557
(FAA_hydrolase)
5 ILE X 251
THR X 160
THR X 253
VAL X  76
PRO X  73
None
1.17A 3kpdB-2q1dX:
undetectable
3kpdB-2q1dX:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc3 CBS DOMAIN

(Nitrosomonas
europaea)
PF00571
(CBS)
7 ILE A  72
THR A  74
ASP A  77
LYS A  81
THR A  99
VAL A 102
PRO A 127
None
BR  A 171 (-4.0A)
None
None
BR  A 177 ( 4.2A)
None
None
0.84A 3kpdB-2rc3A:
18.3
3kpdB-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00571
(CBS)
5 ILE A 312
ASP A 317
THR A 200
SER A 226
PRO A 229
AMP  A1324 (-3.7A)
AMP  A1324 (-2.9A)
AMP  A1324 (-3.0A)
AMP  A1324 (-2.7A)
None
0.53A 3kpdB-2uv7A:
15.4
3kpdB-2uv7A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE


(Thermobacillus
xylanilyticus)
PF06964
(Alpha-L-AF_C)
5 THR A 386
VAL A   7
ILE A 431
ILE A 416
SER A 417
None
0.98A 3kpdB-2vrkA:
undetectable
3kpdB-2vrkA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780


(Pyrococcus
horikoshii)
PF00571
(CBS)
5 ILE A 106
THR A 108
ASP A 111
THR A   8
PRO A  36
None
0.69A 3kpdB-2yzqA:
15.8
3kpdB-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780


(Pyrococcus
horikoshii)
PF00571
(CBS)
7 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
PRO A 256
SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-4.6A)
0.54A 3kpdB-2yzqA:
15.8
3kpdB-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN


(Sulfolobus
solfataricus)
PF00571
(CBS)
5 ILE A 254
THR A 256
ASP A 259
VAL A 147
PRO A 172
AMP  A 278 ( 4.5A)
AMP  A 278 (-3.1A)
AMP  A 278 (-2.7A)
AMP  A 278 ( 3.6A)
AMP  A 278 (-4.7A)
0.33A 3kpdB-3ddjA:
12.6
3kpdB-3ddjA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN


(Sulfolobus
solfataricus)
PF00571
(CBS)
5 THR A  47
ASP A  50
THR A  81
ASN A 104
PRO A 109
PEG  A 279 (-4.4A)
None
None
None
None
0.78A 3kpdB-3ddjA:
12.6
3kpdB-3ddjA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec2 DNA REPLICATION
PROTEIN DNAC


(Aquifex
aeolicus)
PF01695
(IstB_IS21)
5 ILE A 103
THR A  99
VAL A  71
ASN A 215
SER A 176
None
1.16A 3kpdB-3ec2A:
undetectable
3kpdB-3ec2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhm UNCHARACTERIZED
PROTEIN ATU1752


(Agrobacterium
fabrum)
PF00571
(CBS)
6 ILE A  52
THR A  54
ASP A  57
THR A  79
VAL A  82
PRO A 107
AMP  A 200 (-4.0A)
AMP  A 200 (-2.9A)
AMP  A 200 (-2.9A)
AMP  A 200 (-3.5A)
AMP  A 200 ( 4.3A)
AMP  A 200 (-4.7A)
0.51A 3kpdB-3fhmA:
17.5
3kpdB-3fhmA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B


(Saccharomyces
cerevisiae)
PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
5 ILE A 396
THR A 398
ILE A 476
SER A 419
PRO A 426
None
1.07A 3kpdB-3floA:
undetectable
3kpdB-3floA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00571
(CBS)
5 ILE A 259
THR A 261
ASP A 264
THR A 285
ILE A 289
AMP  A 401 (-4.8A)
AMP  A 401 (-3.1A)
AMP  A 401 (-2.7A)
AMP  A 401 (-3.1A)
None
0.93A 3kpdB-3fnaA:
15.1
3kpdB-3fnaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00571
(CBS)
5 ILE A 259
THR A 261
ASP A 264
THR A 285
ILE A 309
AMP  A 401 (-4.8A)
AMP  A 401 (-3.1A)
AMP  A 401 (-2.7A)
AMP  A 401 (-3.1A)
AMP  A 401 (-4.4A)
1.07A 3kpdB-3fnaA:
15.1
3kpdB-3fnaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilh TWO COMPONENT
RESPONSE REGULATOR


(Cytophaga
hutchinsonii)
PF00072
(Response_reg)
5 ILE A  27
THR A  30
VAL A  33
ILE A   7
ASN A 129
None
1.12A 3kpdB-3ilhA:
undetectable
3kpdB-3ilhA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5


(Cypovirus 1)
no annotation 5 ILE D 230
THR D 233
ILE D  79
ILE D 187
SER D 188
None
1.19A 3kpdB-3jazD:
undetectable
3kpdB-3jazD:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE


(Klebsiella
pneumoniae)
PF00571
(CBS)
5 ILE A 258
THR A 260
ASP A 263
THR A 284
ILE A 288
CMK  A   1 (-4.2A)
CMK  A   1 (-3.4A)
CMK  A   1 (-2.8A)
CMK  A   1 (-3.1A)
CMK  A   1 (-3.7A)
0.97A 3kpdB-3k2vA:
15.4
3kpdB-3k2vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE


(Klebsiella
pneumoniae)
PF00571
(CBS)
5 ILE A 258
THR A 260
ASP A 263
THR A 284
ILE A 308
CMK  A   1 (-4.2A)
CMK  A   1 (-3.4A)
CMK  A   1 (-2.8A)
CMK  A   1 (-3.1A)
CMK  A   1 (-3.7A)
0.83A 3kpdB-3k2vA:
15.4
3kpdB-3k2vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE


(Klebsiella
pneumoniae)
PF00571
(CBS)
5 ILE A 258
THR A 260
THR A 284
ILE A 288
ILE A 308
CMK  A   1 (-4.2A)
CMK  A   1 (-3.4A)
CMK  A   1 (-3.1A)
CMK  A   1 (-3.7A)
CMK  A   1 (-3.7A)
0.89A 3kpdB-3k2vA:
15.4
3kpdB-3k2vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbq PROTEIN TA0487

(Thermoplasma
acidophilum)
PF00994
(MoCF_biosynth)
5 ILE A  49
THR A  77
VAL A  42
ASN A  21
SER A  65
None
1.17A 3kpdB-3kbqA:
undetectable
3kpdB-3kbqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf8 PROTEIN TEN1

(Candida
tropicalis)
PF12658
(Ten1)
5 ILE B  58
ILE B  82
ASN B  92
ILE B  91
PRO B   8
None
1.11A 3kpdB-3kf8B:
undetectable
3kpdB-3kf8B:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A  51
LYS A  66
VAL A  94
ILE A  95
PRO A 119
ADP  A 283 ( 4.2A)
ADP  A 283 ( 4.4A)
ADP  A 283 (-3.7A)
ADP  A 283 (-3.8A)
None
1.15A 3kpdB-3kh5A:
12.7
3kpdB-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
7 ILE A  51
THR A  53
ASP A  56
VAL A  94
ILE A  95
ASN A 114
PRO A 119
ADP  A 283 ( 4.2A)
ADP  A 283 (-2.7A)
ADP  A 283 (-2.8A)
ADP  A 283 (-3.7A)
ADP  A 283 (-3.8A)
ADP  A 284 ( 4.9A)
None
0.58A 3kpdB-3kh5A:
12.7
3kpdB-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
7 ILE A 193
THR A 195
ASP A 198
VAL A 233
ILE A 234
ILE A 254
PRO A 258
AMP  A 282 ( 4.3A)
AMP  A 282 (-3.1A)
AMP  A 282 (-3.1A)
AMP  A 282 (-3.8A)
AMP  A 282 (-3.9A)
AMP  A 282 (-4.1A)
None
0.46A 3kpdB-3kh5A:
12.7
3kpdB-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
7 ILE A 193
THR A 195
LYS A 201
VAL A 233
ILE A 234
ILE A 254
PRO A 258
AMP  A 282 ( 4.3A)
AMP  A 282 (-3.1A)
AMP  A 282 ( 3.7A)
AMP  A 282 (-3.8A)
AMP  A 282 (-3.9A)
AMP  A 282 (-4.1A)
None
0.82A 3kpdB-3kh5A:
12.7
3kpdB-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
8 ILE A 269
THR A 271
ASP A 274
LYS A 277
THR A 155
VAL A 158
ILE A 159
PRO A 183
ADP  A 284 ( 4.3A)
ADP  A 284 (-3.4A)
ADP  A 284 (-2.8A)
ADP  A 284 (-3.5A)
ADP  A 284 (-3.2A)
ADP  A 284 (-3.9A)
ADP  A 284 (-4.2A)
None
0.43A 3kpdB-3kh5A:
12.7
3kpdB-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A 269
THR A 271
ASP A 274
THR A 155
ASN A 114
ADP  A 284 ( 4.3A)
ADP  A 284 (-3.4A)
ADP  A 284 (-2.8A)
ADP  A 284 (-3.2A)
ADP  A 284 ( 4.9A)
1.20A 3kpdB-3kh5A:
12.7
3kpdB-3kh5A:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
10 ILE A 434
THR A 436
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
ASN A 479
ILE A 480
PRO A 484
SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
SAM  A1000 (-4.0A)
None
0.80A 3kpdB-3kpbA:
21.9
3kpdB-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
9 ILE A 434
THR A 436
TRP A 438
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
PRO A 484
SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
0.80A 3kpdB-3kpbA:
21.9
3kpdB-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
8 ILE A 434
THR A 436
VAL A 459
ILE A 460
ASN A 479
ILE A 480
SER A 481
PRO A 484
SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
None
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
None
0.68A 3kpdB-3kpbA:
21.9
3kpdB-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
7 ILE A 495
THR A 497
ASP A 500
ILE A 399
ASN A 418
ILE A 419
PRO A 423
None
0.76A 3kpdB-3kpbA:
21.9
3kpdB-3kpbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocm PUTATIVE MEMBRANE
PROTEIN


(Bordetella
parapertussis)
PF00571
(CBS)
5 THR A 443
ASP A 446
THR A 339
VAL A 344
PRO A 369
ADP  A 470 (-3.0A)
ADP  A 470 (-2.8A)
ADP  A 470 (-3.6A)
ADP  A 470 ( 4.0A)
None
0.65A 3kpdB-3ocmA:
10.1
3kpdB-3ocmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oop LIN2960 PROTEIN

(Listeria
innocua)
PF01047
(MarR)
5 THR A  58
VAL A  39
ILE A  43
ILE A  49
SER A  50
None
1.17A 3kpdB-3oopA:
undetectable
3kpdB-3oopA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3v PTS SYSTEM,
N-ACETYLGALACTOSAMIN
E-SPECIFIC IIB
COMPONENT


(Streptococcus
pyogenes)
PF03830
(PTSIIB_sorb)
5 ILE A 117
THR A 118
ILE A 108
ASN A 104
ILE A 105
None
1.18A 3kpdB-3p3vA:
undetectable
3kpdB-3p3vA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Candida
albicans)
PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N)
5 ILE A  18
VAL A  32
ILE A  35
ASN A 106
ILE A 105
None
1.03A 3kpdB-3qo7A:
undetectable
3kpdB-3qo7A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A  65
THR A  67
VAL A 145
ILE A 146
ILE A 149
None
1.06A 3kpdB-3ramA:
undetectable
3kpdB-3ramA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A 137
THR A 139
ASP A 142
ILE A 183
PRO A 187
None
0.87A 3kpdB-3tsdA:
14.6
3kpdB-3tsdA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
5 THR A 139
ASP A 142
ILE A 163
ILE A 183
PRO A 187
None
0.82A 3kpdB-3tsdA:
14.6
3kpdB-3tsdA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2b POLY [ADP-RIBOSE]
POLYMERASE 15


(Homo sapiens)
PF01661
(Macro)
5 THR A 303
VAL A 300
ILE A 299
ILE A 317
PRO A 384
None
1.03A 3kpdB-3v2bA:
undetectable
3kpdB-3v2bA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zd1 COMPLEMENT FACTOR
H-RELATED PROTEIN 2


(Homo sapiens)
PF00084
(Sushi)
5 ILE A 142
THR A 143
VAL A 156
ILE A 172
PRO A 134
EDO  A1257 (-4.7A)
None
None
None
None
1.13A 3kpdB-3zd1A:
undetectable
3kpdB-3zd1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpy ALGINATE LYASE,
FAMILY PL7


(Zobellia
galactanivorans)
PF08787
(Alginate_lyase2)
5 ILE A 215
THR A 233
ASP A 231
ILE A 208
ASN A 211
None
1.17A 3kpdB-3zpyA:
undetectable
3kpdB-3zpyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)


(Geobacillus
stearothermophilus)
PF01281
(Ribosomal_L9_N)
PF03948
(Ribosomal_L9_C)
6 ILE K 121
THR K 127
VAL K 145
ILE K  79
ILE K  98
SER K  95
None
1.36A 3kpdB-487dK:
undetectable
3kpdB-487dK:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aey D-ERYTHRO-7,8-DIHYDR
ONEOPTERIN
TRIPHOSPHATE
EPIMERASE


(Pseudomonas
aeruginosa)
PF02152
(FolB)
5 ILE A  68
THR A  64
ILE A  86
ASN A  38
ILE A  37
None
1.03A 3kpdB-4aeyA:
undetectable
3kpdB-4aeyA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esy CBS DOMAIN
CONTAINING MEMBRANE
PROTEIN


(Sphaerobacter
thermophilus)
PF00571
(CBS)
5 ILE A 359
THR A 361
ASP A 364
THR A 407
ILE A 431
None
1.04A 3kpdB-4esyA:
14.4
3kpdB-4esyA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS


(Burkholderia
ambifaria)
PF00571
(CBS)
7 ILE A  54
THR A  56
ASP A  59
LYS A  63
THR A  81
VAL A  84
PRO A 109
AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 ( 4.1A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
AMP  A 202 (-4.7A)
0.74A 3kpdB-4fryA:
17.0
3kpdB-4fryA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus)
PF00144
(Beta-lactamase)
5 ILE A 278
VAL A  64
ILE A  63
ASN A 366
ILE A 347
None
0.98A 3kpdB-4gdnA:
undetectable
3kpdB-4gdnA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN


(Ustilago maydis)
PF01336
(tRNA_anti-codon)
PF08646
(Rep_fac-A_C)
PF16900
(REPA_OB_2)
5 ILE C 255
THR C 282
ILE C 231
ASN C 261
ILE C 276
None
1.18A 3kpdB-4gnxC:
undetectable
3kpdB-4gnxC:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqw CBS
DOMAIN-CONTAINING
PROTEIN CBSX1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00571
(CBS)
5 ILE A 215
THR A 217
THR A  82
ILE A 108
PRO A 112
None
1.10A 3kpdB-4gqwA:
16.2
3kpdB-4gqwA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP


(Plasmodium
falciparum)
PF00092
(VWA)
5 ILE A 159
LYS A 130
THR A 161
VAL A 187
SER A 171
None
None
None
None
CL  A 401 ( 3.9A)
1.19A 3kpdB-4hqfA:
undetectable
3kpdB-4hqfA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iys METAL TRANSPORTER
CNNM2


(Homo sapiens)
PF00571
(CBS)
5 ILE A 566
THR A 568
ASP A 571
THR A 451
PRO A 482
None
0.85A 3kpdB-4iysA:
10.9
3kpdB-4iysA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgk THG1-LIKE
UNCHARACTERIZED
PROTEIN


(Bacillus
thuringiensis)
PF04446
(Thg1)
5 ILE A 100
VAL A  27
ILE A  79
ASN A  63
ILE A  64
None
1.16A 3kpdB-4kgkA:
undetectable
3kpdB-4kgkA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb8 UNCHARACTERIZED
PROTEIN


(Bacteroides
thetaiotaomicron)
PF16140
(DUF4848)
5 ILE A 291
THR A 290
VAL A 308
ILE A 189
SER A 184
None
1.19A 3kpdB-4lb8A:
undetectable
3kpdB-4lb8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9k ARABINOSE
5-PHOSPHATE
ISOMERASE


(Methylococcus
capsulatus)
PF00571
(CBS)
5 THR A 256
ASP A 259
THR A 280
ILE A 304
PRO A 308
CMK  A 401 (-3.4A)
CMK  A 401 (-2.6A)
CMK  A 401 (-3.1A)
CMK  A 401 (-3.5A)
CMK  A 401 (-4.5A)
0.58A 3kpdB-4o9kA:
16.5
3kpdB-4o9kA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5h HEAT-LABILE
ENTEROTOXIN B CHAIN


(Clostridium
perfringens)
PF03505
(Clenterotox)
5 ASP A 201
LYS A 237
VAL A  43
ILE A  44
ILE A 142
None
1.14A 3kpdB-4p5hA:
undetectable
3kpdB-4p5hA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes)
no annotation 5 ASP H1037
VAL H1041
ILE H1042
ASN H 479
ILE H1055
None
1.13A 3kpdB-4qslH:
undetectable
3kpdB-4qslH:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00571
(CBS)
5 ILE G 312
ASP G 317
THR G 200
SER G 226
PRO G 229
AMP  G 403 (-3.6A)
AMP  G 403 (-2.9A)
AMP  G 403 (-3.5A)
AMP  G 403 (-2.3A)
None
0.69A 3kpdB-4rerG:
10.8
3kpdB-4rerG:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE


(Thermus
thermophilus)
PF00571
(CBS)
5 ILE A 120
THR A 122
ASP A 125
THR A   8
PRO A  36
None
0.68A 3kpdB-5aweA:
11.9
3kpdB-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE


(Thermus
thermophilus)
PF00571
(CBS)
5 THR A  48
ASP A  51
VAL A  85
ILE A 106
PRO A 110
None
0.58A 3kpdB-5aweA:
11.9
3kpdB-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN


(Chaetomium
thermophilum)
PF01008
(IF-2B)
5 ILE A 334
VAL A 311
ILE A 286
ASN A 281
ILE A 280
None
1.14A 3kpdB-5dboA:
undetectable
3kpdB-5dboA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5x SITE-2 PROTEASE

(Archaeoglobus
fulgidus)
PF00571
(CBS)
6 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
PRO A 325
ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
None
0.55A 3kpdB-5g5xA:
17.0
3kpdB-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540


(Arabidopsis
thaliana)
PF13855
(LRR_8)
5 TRP B 390
ASP B 412
ILE B 350
ASN B 368
ILE B 365
None
1.18A 3kpdB-5hz1B:
undetectable
3kpdB-5hz1B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE


(Anabaena)
no annotation 5 ILE B  77
THR B  81
ILE B 350
ILE B  67
PRO B 348
None
1.13A 3kpdB-5ltmB:
undetectable
3kpdB-5ltmB:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE


(Anabaena)
no annotation 5 THR B  81
ILE B 350
ASN B  68
ILE B  67
PRO B 348
None
1.05A 3kpdB-5ltmB:
undetectable
3kpdB-5ltmB:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa)
no annotation 5 ILE A  52
ASP A  57
LYS A  61
ILE A 103
PRO A 107
None
1.01A 3kpdB-5nvdA:
15.3
3kpdB-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa)
no annotation 5 ILE A  52
THR A  54
ASP A  57
LYS A  61
ILE A 103
None
0.62A 3kpdB-5nvdA:
15.3
3kpdB-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa)
no annotation 5 ILE A 117
ASP A 122
LYS A 126
THR A  12
VAL A  15
None
0.94A 3kpdB-5nvdA:
15.3
3kpdB-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H


(Homo sapiens)
PF00084
(Sushi)
5 ILE C1120
THR C1121
VAL C1134
ILE C1150
PRO C1112
None
1.16A 3kpdB-5o32C:
undetectable
3kpdB-5o32C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB


(Shigella
flexneri)
PF00006
(ATP-synt_ab)
5 ILE A 140
ASP A 144
THR A 138
ILE A 327
PRO A 340
None
1.14A 3kpdB-5swjA:
undetectable
3kpdB-5swjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Eremothecium
gossypii)
PF00478
(IMPDH)
PF00571
(CBS)
7 ILE A 163
THR A 165
ASP A 168
THR A 184
VAL A 187
ILE A 188
PRO A 212
ATP  A 601 ( 4.6A)
ATP  A 601 (-2.7A)
ATP  A 601 (-2.3A)
ATP  A 601 (-2.8A)
ATP  A 601 (-4.0A)
ATP  A 601 (-4.2A)
ATP  A 601 ( 4.9A)
0.43A 3kpdB-5tc3A:
14.0
3kpdB-5tc3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uic TWO-COMPONENT
RESPONSE REGULATOR


(Francisella
tularensis)
PF00072
(Response_reg)
5 ILE A  75
VAL A  73
ILE A  71
ASN A  68
ILE A  66
None
1.19A 3kpdB-5uicA:
undetectable
3kpdB-5uicA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT


(Methylobacillus
sp. KY4400)
no annotation 5 ILE C 253
THR C 518
ASP C 517
VAL C 226
ILE C 224
None
GOL  C 811 (-4.8A)
None
None
None
1.14A 3kpdB-5y6qC:
undetectable
3kpdB-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-)
no annotation 5 ILE A 581
THR A 376
THR A 582
ILE A 578
ILE A 575
None
1.19A 3kpdB-5yh1A:
undetectable
3kpdB-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b)
no annotation 5 ILE A 368
THR A 115
THR A 241
ASN A 107
ILE A 108
None
None
HEM  A 501 (-3.4A)
None
None
1.08A 3kpdB-5yhjA:
undetectable
3kpdB-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
no annotation 5 ILE A 719
VAL A 708
ILE A 707
ASN A 730
ILE A 727
None
1.10A 3kpdB-5ywzA:
undetectable
3kpdB-5ywzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 5 ILE A  10
ASP A  12
THR A  51
VAL A  53
SER A 793
None
1.02A 3kpdB-6bogA:
undetectable
3kpdB-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT


(Tetrahymena
thermophila)
no annotation 5 VAL E  99
ILE E 100
ILE E  85
SER E  78
PRO E  83
None
1.11A 3kpdB-6d6vE:
undetectable
3kpdB-6d6vE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE


(Legionella
pneumophila)
no annotation 5 THR A 271
VAL A 266
ILE A 191
ILE A 215
SER A 214
None
1.11A 3kpdB-6eslA:
undetectable
3kpdB-6eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)


(Saccharomyces
cerevisiae)
PF01088
(Peptidase_C12)
3 ASN A 225
ASN A  62
GLU A 221
None
0.94A 3kpdC-1cmxA:
0.0
3kpdC-1cmxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fh0 CATHEPSIN V

(Homo sapiens)
PF00112
(Peptidase_C1)
3 ASN A 187
ASN A  18
GLU A 192
None
0.75A 3kpdC-1fh0A:
0.0
3kpdC-1fh0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ
BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ


(Escherichia
virus G4;
Escherichia
virus G4)
PF02305
(Phage_F)
PF02306
(Phage_G)
3 ASN 2  69
ASN 1 388
GLU 1 154
None
0.93A 3kpdC-1gff2:
0.0
3kpdC-1gff2:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE


(Homo sapiens)
PF00102
(Y_phosphatase)
3 ASN A 243
ASN A 250
GLU A  78
None
0.90A 3kpdC-1l8kA:
0.0
3kpdC-1l8kA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae)
PF00995
(Sec1)
3 ASN A 324
ASN A 293
GLU A 167
None
0.84A 3kpdC-1mqsA:
0.0
3kpdC-1mqsA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg6 HYPOTHETICAL PROTEIN
SPYM3_0169


(Streptococcus
pyogenes)
PF01987
(AIM24)
3 ASN A 173
ASN A 219
GLU A 201
None
0.88A 3kpdC-1pg6A:
0.0
3kpdC-1pg6A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE


(Saccharomyces
cerevisiae)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 ASN A 157
ASN A  95
GLU A 153
None
0.68A 3kpdC-1pxtA:
0.0
3kpdC-1pxtA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 ASN A 102
ASN A  12
GLU A  69
CA  A 905 (-3.5A)
CA  A 907 (-3.3A)
CA  A 906 ( 2.4A)
0.80A 3kpdC-1q5aA:
undetectable
3kpdC-1q5aA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE


(Thermotoga
maritima)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
3 ASN A 167
ASN A 239
GLU A 333
None
0.91A 3kpdC-1up4A:
undetectable
3kpdC-1up4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE


(Cellvibrio
japonicus)
PF00331
(Glyco_hydro_10)
PF03426
(CBM_15)
3 ASN A 440
ASN A 435
GLU A 437
None
0.92A 3kpdC-1us2A:
undetectable
3kpdC-1us2A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE


(Pyrobaculum
islandicum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 ASN A 253
ASN A 277
GLU A 250
None
0.79A 3kpdC-1v9lA:
undetectable
3kpdC-1v9lA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE


(Ruminiclostridium
thermocellum)
PF00331
(Glyco_hydro_10)
3 ASN A 813
ASN A 726
GLU A 763
None
0.93A 3kpdC-1xyzA:
undetectable
3kpdC-1xyzA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34


(Clostridium
botulinum)
PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2)
3 ASN A 195
ASN A 151
GLU A 143
None
0.76A 3kpdC-1ybiA:
undetectable
3kpdC-1ybiA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens)
PF13088
(BNR_2)
3 ASN A 514
ASN A 516
GLU A 511
None
0.91A 3kpdC-2bf6A:
undetectable
3kpdC-2bf6A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE


(Xanthobacter
autotrophicus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 ASN A  35
ASN A   5
GLU A  38
None
0.94A 3kpdC-2c3dA:
undetectable
3kpdC-2c3dA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1


(Saccharomyces
cerevisiae)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
3 ASN A 599
ASN A 499
GLU A 433
None
0.84A 3kpdC-2cvtA:
undetectable
3kpdC-2cvtA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi0 CONSERVED DOMAIN
PROTEIN


(Streptococcus
pneumoniae)
PF08984
(DUF1858)
3 ASN A  73
ASN A   7
GLU A  24
None
0.88A 3kpdC-2fi0A:
undetectable
3kpdC-2fi0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2


(Mus musculus)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
3 ASN A  47
ASN A  15
GLU A  51
None
MG  A 260 (-4.1A)
PO4  A 404 (-3.7A)
0.85A 3kpdC-2ho4A:
undetectable
3kpdC-2ho4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens)
PF00194
(Carb_anhydrase)
3 ASN A  24
ASN A  26
GLU A 205
None
0.92A 3kpdC-2it4A:
undetectable
3kpdC-2it4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY


(Enterococcus
faecalis)
PF04198
(Sugar-bind)
3 ASN A 197
ASN A 202
GLU A 165
None
0.74A 3kpdC-2o0mA:
undetectable
3kpdC-2o0mA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE

(Nostoc sp. PCC
7120)
PF01223
(Endonuclease_NS)
3 ASN A 157
ASN A 155
GLU A 163
None
MG  A 303 (-2.8A)
MG  A 303 ( 3.9A)
0.94A 3kpdC-2o3bA:
undetectable
3kpdC-2o3bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis)
PF00378
(ECH_1)
3 ASN A 391
ASN A 396
GLU A 282
None
0.90A 3kpdC-2pg8A:
undetectable
3kpdC-2pg8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C


(Listeria
monocytogenes)
PF00388
(PI-PLC-X)
3 ASN A 287
ASN A 255
GLU A 281
None
0.87A 3kpdC-2plcA:
undetectable
3kpdC-2plcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4


(Saccharomyces
cerevisiae)
PF00439
(Bromodomain)
3 ASN A  43
ASN A 286
GLU A  47
None
0.87A 3kpdC-2r0sA:
undetectable
3kpdC-2r0sA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae)
PF13088
(BNR_2)
3 ASN A 623
ASN A 625
GLU A 620
None
0.92A 3kpdC-2w20A:
undetectable
3kpdC-2w20A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT


(Homo sapiens)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
3 ASN A 595
ASN A 495
GLU A 434
None
0.85A 3kpdC-2wghA:
undetectable
3kpdC-2wghA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1


(Homo sapiens)
PF01026
(TatD_DNase)
3 ASN A  53
ASN A  87
GLU A  95
None
0.71A 3kpdC-2xioA:
undetectable
3kpdC-2xioA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
3 ASN A 440
ASN A 407
GLU A 433
None
0.69A 3kpdC-3cemA:
undetectable
3kpdC-3cemA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Bordetella
bronchiseptica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ASN A 155
ASN A 188
GLU A 160
None
0.85A 3kpdC-3ddmA:
undetectable
3kpdC-3ddmA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN


(Vibrio
parahaemolyticus)
PF01965
(DJ-1_PfpI)
3 ASN A  76
ASN A 162
GLU A 182
None
0.78A 3kpdC-3er6A:
undetectable
3kpdC-3er6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6a HYDROLASE, NUDIX
FAMILY


(Clostridium
perfringens)
PF00293
(NUDIX)
3 ASN A  81
ASN A  61
GLU A  42
None
0.91A 3kpdC-3f6aA:
undetectable
3kpdC-3f6aA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE


(Bacteroides
fragilis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 ASN A 451
ASN A 418
GLU A 503
None
0.91A 3kpdC-3fn9A:
undetectable
3kpdC-3fn9A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Clostridium
acetobutylicum)
PF00155
(Aminotran_1_2)
3 ASN A  47
ASN A  54
GLU A 252
None
0.89A 3kpdC-3ftbA:
undetectable
3kpdC-3ftbA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis)
PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3)
3 ASN A 368
ASN A 328
GLU A 502
None
0.89A 3kpdC-3hvdA:
undetectable
3kpdC-3hvdA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA


(Moorella
thermoacetica;
Moorella
thermoacetica)
PF03063
(Prismane)
PF03598
(CdhC)
3 ASN A 202
ASN A 229
GLU M  37
None
0.80A 3kpdC-3i04A:
undetectable
3kpdC-3i04A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus)
PF01766
(Birna_VP2)
3 ASN A 153
ASN A 139
GLU A 356
None
0.69A 3kpdC-3ideA:
undetectable
3kpdC-3ideA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2


(Streptococcus
mutans)
PF01791
(DeoC)
3 ASN A 211
ASN A 174
GLU A 207
EDO  A 334 (-3.5A)
EDO  A 334 (-3.7A)
EDO  A 334 ( 4.9A)
0.93A 3kpdC-3iv3A:
undetectable
3kpdC-3iv3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik)
no annotation 3 ASN A 438
ASN A 362
GLU A 431
None
0.87A 3kpdC-3j26A:
undetectable
3kpdC-3j26A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Staphylococcus
aureus)
PF01791
(DeoC)
3 ASN A 211
ASN A 174
GLU A 207
None
0.94A 3kpdC-3kaoA:
undetectable
3kpdC-3kaoA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE


(Desulfococcus
multivorans)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
3 ASN A  91
ASN A 162
GLU A  93
GRA  A 402 (-3.8A)
None
None
0.94A 3kpdC-3mpiA:
undetectable
3kpdC-3mpiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvx PROTEIN A39

(Vaccinia virus)
PF01403
(Sema)
3 ASN A  59
ASN A 107
GLU A  23
None
0.92A 3kpdC-3nvxA:
undetectable
3kpdC-3nvxA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
3 ASN A 234
ASN A 199
GLU A 298
None
GAL  A1024 (-3.1A)
GAL  A1024 (-2.7A)
0.89A 3kpdC-3ogrA:
undetectable
3kpdC-3ogrA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus)
PF03566
(Peptidase_A21)
3 ASN A 484
ASN A 191
GLU A 428
None
0.82A 3kpdC-3s6pA:
undetectable
3kpdC-3s6pA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td7 FAD-LINKED
SULFHYDRYL OXIDASE
R596


(Acanthamoeba
polyphaga
mimivirus)
PF04777
(Evr1_Alr)
3 ASN A 279
ASN A 185
GLU A 285
None
0.76A 3kpdC-3td7A:
undetectable
3kpdC-3td7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis)
PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3)
3 ASN A 368
ASN A 328
GLU A 502
None
0.89A 3kpdC-3texA:
undetectable
3kpdC-3texA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE


(Arabidopsis
thaliana;
Vitis vinifera)
PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C)
3 ASN A 122
ASN A  82
GLU A 125
None
0.73A 3kpdC-3tsyA:
undetectable
3kpdC-3tsyA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2


(Thermus
thermophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 ASN A 403
ASN A 450
GLU A 656
None
0.86A 3kpdC-3viuA:
undetectable
3kpdC-3viuA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)


(Bacteroides
ovatus)
PF00150
(Cellulase)
PF13004
(BACON)
3 ASN A 162
ASN A 165
GLU A 478
None
BGC  A1520 (-3.2A)
None
0.82A 3kpdC-3zmrA:
undetectable
3kpdC-3zmrA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)


(Bacteroides
ovatus)
PF00150
(Cellulase)
PF13004
(BACON)
3 ASN A 345
ASN A 296
GLU A 369
EDO  A1516 (-4.6A)
BGC  A1518 (-2.8A)
None
0.82A 3kpdC-3zmrA:
undetectable
3kpdC-3zmrA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuy TRANSPORTER

(Neisseria
meningitidis)
PF01758
(SBF)
3 ASN A 124
ASN A 115
GLU A 260
None
NA  A1310 (-3.3A)
NA  A1310 ( 2.6A)
0.93A 3kpdC-3zuyA:
undetectable
3kpdC-3zuyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
3 ASN A 534
ASN A 428
GLU A 358
MG  A1771 (-2.5A)
None
None
0.94A 3kpdC-4a01A:
undetectable
3kpdC-4a01A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dp0 PLASTOCYANIN B,
CHLOROPLASTIC


(Populus nigra)
PF00127
(Copper-bind)
3 ASN X  38
ASN X  64
GLU X  68
None
0.92A 3kpdC-4dp0X:
undetectable
3kpdC-4dp0X:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 ASN A 133
ASN A 102
GLU A 138
None
0.94A 3kpdC-4dzaA:
undetectable
3kpdC-4dzaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27


(Homo sapiens)
no annotation 3 ASN D 205
ASN D 169
GLU D 216
None
0.88A 3kpdC-4f9zD:
undetectable
3kpdC-4f9zD:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes)
PF13416
(SBP_bac_8)
3 ASN A 283
ASN A 290
GLU A  57
None
0.93A 3kpdC-4gl0A:
undetectable
3kpdC-4gl0A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00169
(PH)
PF00788
(RA)
3 ASN A 339
ASN A 449
GLU A 331
MLI  A 601 (-3.7A)
MLI  A 601 (-4.0A)
None
0.85A 3kpdC-4gn1A:
undetectable
3kpdC-4gn1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP


(Plasmodium
falciparum)
PF00092
(VWA)
3 ASN A 152
ASN A 154
GLU A 239
None
0.86A 3kpdC-4hqfA:
undetectable
3kpdC-4hqfA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica)
PF00291
(PALP)
3 ASN A 165
ASN A 158
GLU A  83
None
0.84A 3kpdC-4il5A:
undetectable
3kpdC-4il5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE


(Bacillus
megaterium)
PF00561
(Abhydrolase_1)
3 ASN A   9
ASN A   7
GLU A  62
None
0.90A 3kpdC-4inzA:
undetectable
3kpdC-4inzA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 ASN A 445
ASN A 412
GLU A 504
None
0.85A 3kpdC-4jhzA:
undetectable
3kpdC-4jhzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 ASN A 441
ASN A 407
GLU A 501
None
0.86A 3kpdC-4jklA:
undetectable
3kpdC-4jklA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7s BTRN

(Bacillus
circulans)
PF13186
(SPASM)
3 ASN A 234
ASN A 236
GLU A 189
None
0.85A 3kpdC-4m7sA:
undetectable
3kpdC-4m7sA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis)
PF00561
(Abhydrolase_1)
3 ASN A 283
ASN A 170
GLU A 133
None
0.85A 3kpdC-4meaA:
undetectable
3kpdC-4meaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE


(Entamoeba
histolytica)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 ASN A 102
ASN A 272
GLU A 267
None
0.93A 3kpdC-4nfyA:
undetectable
3kpdC-4nfyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT


(Rhodopseudomonas
palustris)
PF03480
(DctP)
3 ASN A 268
ASN A 275
GLU A  54
None
0.88A 3kpdC-4oanA:
undetectable
3kpdC-4oanA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN


(Escherichia
coli;
Mus musculus)
PF00225
(Kinesin)
PF13416
(SBP_bac_8)
3 ASN A-220
ASN A-143
GLU A-156
None
0.94A 3kpdC-4ozqA:
undetectable
3kpdC-4ozqA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3m MGS-M4

(unidentified)
PF00248
(Aldo_ket_red)
3 ASN A 137
ASN A 139
GLU A 268
None
0.84A 3kpdC-4q3mA:
undetectable
3kpdC-4q3mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 ASN A 167
ASN A 136
GLU A 165
None
0.92A 3kpdC-4qciA:
undetectable
3kpdC-4qciA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE


(Mycoplasma
pneumoniae)
PF01266
(DAO)
3 ASN A 179
ASN A 194
GLU A 176
None
0.84A 3kpdC-4x9nA:
undetectable
3kpdC-4x9nA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli)
PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C)
3 ASN A 157
ASN A  63
GLU A  66
None
0.88A 3kpdC-4xjxA:
undetectable
3kpdC-4xjxA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 HT593.1 GP120

(Human
immunodeficiency
virus)
PF00516
(GP120)
3 ASN G 465
ASN G 461
GLU G 468
None
0.65A 3kpdC-4ye4G:
undetectable
3kpdC-4ye4G:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bov PUTATIVE EPOXIDE
HYDROLASE PROTEIN


(Klebsiella
pneumoniae)
PF00561
(Abhydrolase_1)
3 ASN A 250
ASN A 116
GLU A 258
None
0.92A 3kpdC-5bovA:
undetectable
3kpdC-5bovA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2


(Nicotiana
tabacum)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
3 ASN A  86
ASN A  46
GLU A  89
None
0.86A 3kpdC-5bswA:
undetectable
3kpdC-5bswA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2


(Rickettsia
typhi)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
3 ASN A 160
ASN A 151
GLU A 223
None
0.74A 3kpdC-5dooA:
undetectable
3kpdC-5dooA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1


(Rickettsia
prowazekii)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
3 ASN A 372
ASN A 398
GLU A 479
None
0.84A 3kpdC-5dpdA:
undetectable
3kpdC-5dpdA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 ASN A 473
ASN A 405
GLU A 361
None
0.91A 3kpdC-5eodA:
undetectable
3kpdC-5eodA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP120 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
3 ASN G 442
ASN G 302
GLU G 381
NAG  G4421 (-1.8A)
None
None
0.92A 3kpdC-5fyjG:
undetectable
3kpdC-5fyjG:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
3 ASN B 139
ASN B 164
GLU B 118
None
0.86A 3kpdC-5gqrB:
undetectable
3kpdC-5gqrB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL


(Homo sapiens)
PF00180
(Iso_dh)
3 ASN B 130
ASN B 239
GLU B 134
None
0.93A 3kpdC-5grhB:
undetectable
3kpdC-5grhB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gx8 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Streptobacillus
moniliformis)
PF13416
(SBP_bac_8)
3 ASN A 275
ASN A 193
GLU A 198
None
CA  A 601 (-3.1A)
CA  A 601 (-2.2A)
0.88A 3kpdC-5gx8A:
undetectable
3kpdC-5gx8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF03971
(IDH)
3 ASN A 393
ASN A 398
GLU A 533
None
None
EDO  A 803 (-4.0A)
0.84A 3kpdC-5kvuA:
undetectable
3kpdC-5kvuA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN


(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1)
no annotation
no annotation
3 ASN A 939
ASN A 937
GLU B 916
None
0.88A 3kpdC-5nd1A:
undetectable
3kpdC-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A


(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
3 ASN A 935
ASN A1051
GLU A 969
None
0.75A 3kpdC-5tpcA:
undetectable
3kpdC-5tpcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiv BIFUNCTIONAL
THYMIDYLATE/URIDYLAT
E KINASE


(Candida
albicans)
PF02223
(Thymidylate_kin)
3 ASN A  53
ASN A  48
GLU A 159
None
None
TMP  A 301 ( 4.5A)
0.69A 3kpdC-5uivA:
undetectable
3kpdC-5uivA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6t HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
3 ASN A 129
ASN A 131
GLU A 156
None
0.85A 3kpdC-5w6tA:
undetectable
3kpdC-5w6tA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk1 MAJOR CAPSID PROTEIN

(Pseudoalteromonas
phage TW1)
no annotation 3 ASN A 264
ASN A 262
GLU A 219
None
0.81A 3kpdC-5wk1A:
undetectable
3kpdC-5wk1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6


(Rattus
norvegicus)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4)
3 ASN A  57
ASN A  91
GLU A  93
ASN  A  57 ( 0.6A)
ASN  A  91 ( 0.6A)
GLU  A  93 ( 0.6A)
0.88A 3kpdC-5wo6A:
undetectable
3kpdC-5wo6A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE


(Escherichia
coli;
Serratia
marcescens)
no annotation 3 ASN A 152
ASN A 229
GLU A 216
None
0.89A 3kpdC-5wvmA:
undetectable
3kpdC-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS


(Neisseria
gonorrhoeae)
no annotation 3 ASN A 420
ASN A 417
GLU A 518
None
0.93A 3kpdC-5x9wA:
undetectable
3kpdC-5x9wA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum)
no annotation 3 ASN A 148
ASN A 141
GLU A  67
PLP  A 401 ( 4.8A)
ACT  A 403 (-3.9A)
None
0.79A 3kpdC-5xeoA:
undetectable
3kpdC-5xeoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC


(Pisum sativum)
PF01716
(MSP)
3 ASN O 170
ASN O 190
GLU O 183
None
0.78A 3kpdC-5xnlO:
undetectable
3kpdC-5xnlO:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A


(Leptotrichia
buccalis)
no annotation 3 ASN A 250
ASN A 252
GLU A 256
None
0.93A 3kpdC-5xwyA:
undetectable
3kpdC-5xwyA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis)
no annotation 3 ASN A  92
ASN A 153
GLU A  96
None
0.71A 3kpdC-5y3xA:
undetectable
3kpdC-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER


(Roseiflexus
castenholzii)
no annotation 3 ASN L 240
ASN L 245
GLU L 236
None
0.89A 3kpdC-5yq7L:
undetectable
3kpdC-5yq7L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea)
no annotation 3 ASN B 419
ASN B 426
GLU B 549
None
0.90A 3kpdC-6bywB:
undetectable
3kpdC-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans)
no annotation 3 ASN A 137
ASN A 163
GLU A 190
None
0.90A 3kpdC-6cw5A:
undetectable
3kpdC-6cw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-)
no annotation 3 ASN B 294
ASN B 301
GLU B 290
None
NA  A 501 ( 4.8A)
None
0.70A 3kpdC-6dftB:
undetectable
3kpdC-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-)
no annotation 3 ASN A -65
ASN A  12
GLU A  -1
None
0.93A 3kpdC-6dm8A:
undetectable
3kpdC-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1


(Cyanidioschyzon
merolae)
no annotation 3 ASN A 311
ASN A 189
GLU A 191
None
0.93A 3kpdC-6fosA:
undetectable
3kpdC-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-)
no annotation 3 ASN A 391
ASN A 396
GLU A 530
None
0.83A 3kpdC-6g3uA:
undetectable
3kpdC-6g3uA:
undetectable