SIMILAR PATTERNS OF AMINO ACIDS FOR 3KPC_A_SAMA1000_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a3y | ODORANT BINDINGPROTEIN (Sus scrofa) |
PF00061(Lipocalin) | 5 | ILE A 29VAL A 147ILE A 146ASN A 139SER A 24 | None | 1.08A | 3kpcA-1a3yA:0.0 | 3kpcA-1a3yA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1elj | MALTODEXTRIN-BINDINGPROTEIN (Pyrococcusfuriosus) |
PF13416(SBP_bac_8) | 5 | ASP A 319VAL A 244ILE A 121ASN A 233ILE A 232 | None | 1.19A | 3kpcA-1eljA:0.0 | 3kpcA-1eljA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1icp | 12-OXOPHYTODIENOATEREDUCTASE 1 (Solanumlycopersicum) |
PF00724(Oxidored_FMN) | 5 | ILE A 130THR A 74ILE A 162ASN A 167ILE A 165 | None | 1.22A | 3kpcA-1icpA:0.0 | 3kpcA-1icpA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldm | M4 LACTATEDEHYDROGENASE (Squalusacanthias) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | THR A 24VAL A 93ILE A 94ASN A 123ILE A 124 | None | 1.19A | 3kpcA-1ldmA:0.0 | 3kpcA-1ldmA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mab | PROTEIN (F1-ATPASEBETA CHAIN) (Rattusnorvegicus) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | ILE B 108THR B 90THR B 110ILE B 84PRO B 101 | None | 1.19A | 3kpcA-1mabB:undetectable | 3kpcA-1mabB:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ohe | CDC14B2 PHOSPHATASE (Homo sapiens) |
PF00782(DSPc)PF14671(DSPn) | 5 | ILE A 52THR A 53ILE A 118ASN A 105ILE A 104 | None | 1.04A | 3kpcA-1oheA:undetectable | 3kpcA-1oheA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rkx | CDP-GLUCOSE-4,6-DEHYDRATASE (Yersiniapseudotuberculosis) |
PF16363(GDP_Man_Dehyd) | 5 | ILE A 197THR A 325ILE A 207ASN A 274ILE A 275 | None | 1.20A | 3kpcA-1rkxA:undetectable | 3kpcA-1rkxA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrh | SEED LIPOXYGENASE-3 (Glycine max) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | ILE A 12ILE A 111ASN A 164ILE A 141SER A 140 | None | 1.14A | 3kpcA-1rrhA:undetectable | 3kpcA-1rrhA:9.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tis | THYMIDYLATE SYNTHASE (Escherichiavirus T4) |
PF00303(Thymidylat_synt) | 5 | ILE A 197THR A 193TRP A 52VAL A 261ILE A 60 | None | 0.87A | 3kpcA-1tisA:undetectable | 3kpcA-1tisA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ugh | PROTEIN (URACIL-DNAGLYCOSYLASEINHIBITOR) (Bacillus phagePBS2) |
no annotation | 5 | ILE I 41THR I 59VAL I 29ILE I 33PRO I 37 | None | 1.22A | 3kpcA-1ughI:undetectable | 3kpcA-1ughI:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ILE A 131THR A 139ILE A 195ASN A 428PRO A 128 | None | 1.21A | 3kpcA-1v8bA:undetectable | 3kpcA-1v8bA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkf | HYPOTHETICAL PROTEINRV2626C (Mycobacteriumtuberculosis) |
PF00571(CBS) | 6 | ILE A 113THR A 115ASP A 118VAL A 12ILE A 33PRO A 37 | None | 0.94A | 3kpcA-1xkfA:16.7 | 3kpcA-1xkfA:29.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xq1 | PUTATIVE TROPINONEREDUCATSE (Arabidopsisthaliana) |
PF13561(adh_short_C2) | 5 | ILE A 41THR A 43VAL A 31ILE A 30ASN A 98 | None | 1.22A | 3kpcA-1xq1A:undetectable | 3kpcA-1xq1A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xq1 | PUTATIVE TROPINONEREDUCATSE (Arabidopsisthaliana) |
PF13561(adh_short_C2) | 5 | ILE A 41VAL A 31ILE A 30ASN A 98ILE A 97 | None | 1.09A | 3kpcA-1xq1A:undetectable | 3kpcA-1xq1A:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yv7 | P-30 PROTEIN (Rana pipiens) |
PF00074(RnaseA) | 5 | ILE A 47THR A 59VAL A 88ILE A 37PRO A 95 | None | 1.16A | 3kpcA-1yv7A:undetectable | 3kpcA-1yv7A:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 139THR A 141ASP A 144THR A 160PRO A 189 | None | 0.86A | 3kpcA-1zfjA:15.5 | 3kpcA-1zfjA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4v | RNA EDITING COMPLEXPROTEIN MP57 (Trypanosomabrucei) |
PF01909(NTP_transf_2)PF03828(PAP_assoc) | 5 | VAL A 323ILE A 326ILE A 281SER A 278PRO A 422 | None | 1.22A | 3kpcA-2b4vA:undetectable | 3kpcA-2b4vA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5u | COLICIN E3 (Escherichiacoli) |
PF03515(Cloacin)PF09000(Cytotoxic)PF11570(E2R135) | 5 | THR A 267VAL A 287ILE A 155ASN A 195ILE A 196 | None | 1.24A | 3kpcA-2b5uA:undetectable | 3kpcA-2b5uA:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cod | CENTAURIN-DELTA 1 (Homo sapiens) |
PF00169(PH) | 5 | ILE A 57THR A 72VAL A 70ILE A 37SER A 36 | None | 1.26A | 3kpcA-2codA:undetectable | 3kpcA-2codA:19.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ef7 | HYPOTHETICAL PROTEINST2348 (Sulfurisphaeratokodaii) |
PF00571(CBS) | 5 | ILE A 49THR A 51ASP A 54THR A 74ILE A 98 | None | 0.66A | 3kpcA-2ef7A:14.8 | 3kpcA-2ef7A:33.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1f | ACETOLACTATESYNTHASE ISOZYME IIISMALL SUBUNIT (Escherichiacoli) |
PF10369(ALS_ss_C)PF13710(ACT_5) | 5 | VAL A 19ILE A 20ASN A 29ILE A 30SER A 32 | None | 1.27A | 3kpcA-2f1fA:undetectable | 3kpcA-2f1fA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwg | 4-OXALOMESACONATEHYDRATASE (Rhodopseudomonaspalustris) |
PF04909(Amidohydro_2) | 5 | ILE A 274ILE A 221ASN A 254ILE A 255PRO A 229 | None | 1.19A | 3kpcA-2gwgA:undetectable | 3kpcA-2gwgA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j9l | CHLORIDE CHANNELPROTEIN 5 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 722THR A 724ASP A 727SER A 618PRO A 621 | ATP A1752 (-4.1A)ATP A1752 (-2.7A)ATP A1752 (-2.7A)ATP A1752 (-3.3A)None | 0.61A | 3kpcA-2j9lA:13.0 | 3kpcA-2j9lA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kca | BACTERIOPHAGE SPP1COMPLETE NUCLEOTIDESEQUENCE (Bacillus phageSPP1) |
PF05521(Phage_H_T_join) | 5 | ILE A 102THR A 96ASP A 99VAL A 108ILE A 43 | None | 1.27A | 3kpcA-2kcaA:undetectable | 3kpcA-2kcaA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lcq | PUTATIVE TOXIN VAPC6 (Pyrococcushorikoshii) |
PF17146(PIN_6) | 5 | THR A 72VAL A 68ILE A 65ASN A 102ILE A 106 | None | 1.20A | 3kpcA-2lcqA:undetectable | 3kpcA-2lcqA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o16 | ACETOIN UTILIZATIONPROTEIN ACUB,PUTATIVE (Vibrio cholerae) |
PF00571(CBS) | 6 | ILE A 139THR A 141ASP A 144THR A 28ILE A 52PRO A 56 | NonePO4 A 1 (-3.0A)NoneNonePO4 A 1 (-4.4A)None | 0.82A | 3kpcA-2o16A:18.8 | 3kpcA-2o16A:26.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oox | HYPOTHETICAL PROTEINC1556.08C INCHROMOSOME I (Schizosaccharomycespombe) |
no annotation | 7 | ILE G 303ASP G 308THR G 191ASN G 215ILE G 216SER G 217PRO G 220 | AMP G 401 (-4.0A)AMP G 401 (-2.6A)AMP G 401 (-3.7A)NoneAMP G 401 (-3.7A)AMP G 401 (-2.3A)AMP G 401 (-4.7A) | 0.87A | 3kpcA-2ooxG:12.1 | 3kpcA-2ooxG:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oux | MAGNESIUMTRANSPORTER (Enterococcusfaecalis) |
PF00571(CBS)PF03448(MgtE_N) | 5 | VAL A 155ILE A 202ASN A 207ILE A 188SER A 189 | None | 1.18A | 3kpcA-2ouxA:15.4 | 3kpcA-2ouxA:17.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 54THR A 56VAL A 83ILE A 84ILE A 109PRO A 113 | None | 0.66A | 3kpcA-2p9mA:18.4 | 3kpcA-2p9mA:37.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 124ASP A 129THR A 15ILE A 39PRO A 43 | None | 1.05A | 3kpcA-2p9mA:18.4 | 3kpcA-2p9mA:37.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 7 | ILE A 124ASP A 129THR A 15VAL A 18ILE A 19SER A 40PRO A 43 | None | 0.84A | 3kpcA-2p9mA:18.4 | 3kpcA-2p9mA:37.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 124VAL A 18ILE A 19ILE A 39SER A 40PRO A 43 | None | 1.00A | 3kpcA-2p9mA:18.4 | 3kpcA-2p9mA:37.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | THR A 56ASP A 59ILE A 84ILE A 109PRO A 113 | None | 1.05A | 3kpcA-2p9mA:18.4 | 3kpcA-2p9mA:37.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | THR A 56THR A 80VAL A 83ILE A 84ILE A 109PRO A 113 | None | 0.79A | 3kpcA-2p9mA:18.4 | 3kpcA-2p9mA:37.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1d | 2-KETO-3-DEOXY-D-ARABINONATE DEHYDRATASE (Sulfolobussolfataricus) |
PF01557(FAA_hydrolase) | 5 | ILE X 251THR X 160THR X 253VAL X 76PRO X 73 | None | 1.18A | 3kpcA-2q1dX:undetectable | 3kpcA-2q1dX:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc3 | CBS DOMAIN (Nitrosomonaseuropaea) |
PF00571(CBS) | 6 | ILE A 72THR A 74ASP A 77THR A 99VAL A 102PRO A 127 | None BR A 171 (-4.0A)None BR A 177 ( 4.2A)NoneNone | 0.64A | 3kpcA-2rc3A:18.2 | 3kpcA-2rc3A:29.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbf | BRANCHED-CHAINALPHA-KETOACIDDECARBOXYLASE (Lactococcuslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 396THR A 62VAL A 374ILE A 373ASN A 370 | ILE A 396 ( 0.7A)THR A 62 ( 0.8A)VAL A 374 ( 0.5A)ILE A 373 ( 0.7A)ASN A 370 ( 0.6A) | 1.25A | 3kpcA-2vbfA:undetectable | 3kpcA-2vbfA:12.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 5 | ILE A 106THR A 108ASP A 111THR A 8PRO A 36 | None | 0.69A | 3kpcA-2yzqA:16.8 | 3kpcA-2yzqA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 7 | ILE A 172ASP A 177THR A 228VAL A 231ILE A 232ILE A 252PRO A 256 | SAM A6075 (-3.9A)SAM A6075 (-2.8A)SAM A6075 (-3.5A)SAM A6075 (-3.8A)SAM A6075 (-3.9A)SAM A6075 (-3.6A)SAM A6075 (-4.6A) | 0.59A | 3kpcA-2yzqA:16.8 | 3kpcA-2yzqA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b3l | KETOHEXOKINASE (Homo sapiens) |
PF00294(PfkB) | 5 | ILE A 17ASP A 252ILE A 100ASN A 103SER A 34 | None | 1.16A | 3kpcA-3b3lA:undetectable | 3kpcA-3b3lA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddj | CBSDOMAIN-CONTAININGPROTEIN (Sulfolobussolfataricus) |
PF00571(CBS) | 5 | ILE A 254THR A 256ASP A 259VAL A 147PRO A 172 | AMP A 278 ( 4.5A)AMP A 278 (-3.1A)AMP A 278 (-2.7A)AMP A 278 ( 3.6A)AMP A 278 (-4.7A) | 0.30A | 3kpcA-3ddjA:13.6 | 3kpcA-3ddjA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddj | CBSDOMAIN-CONTAININGPROTEIN (Sulfolobussolfataricus) |
PF00571(CBS) | 5 | THR A 47ASP A 50THR A 81ASN A 104PRO A 109 | PEG A 279 (-4.4A)NoneNoneNoneNone | 0.88A | 3kpcA-3ddjA:13.6 | 3kpcA-3ddjA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ec2 | DNA REPLICATIONPROTEIN DNAC (Aquifexaeolicus) |
PF01695(IstB_IS21) | 5 | ILE A 103THR A 99VAL A 71ASN A 215SER A 176 | None | 1.14A | 3kpcA-3ec2A:undetectable | 3kpcA-3ec2A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhm | UNCHARACTERIZEDPROTEIN ATU1752 (Agrobacteriumfabrum) |
PF00571(CBS) | 6 | ILE A 52THR A 54ASP A 57THR A 79VAL A 82PRO A 107 | AMP A 200 (-4.0A)AMP A 200 (-2.9A)AMP A 200 (-2.9A)AMP A 200 (-3.5A)AMP A 200 ( 4.3A)AMP A 200 (-4.7A) | 0.49A | 3kpcA-3fhmA:17.6 | 3kpcA-3fhmA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ILE A 139VAL A 146ILE A 149ILE A 127PRO A 173 | None | 1.27A | 3kpcA-3g1uA:undetectable | 3kpcA-3g1uA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzt | OUTER CAPSIDGLYCOPROTEIN VP7 (Rotavirus A) |
PF00434(VP7) | 5 | THR B 75VAL B 303ILE B 306ASN B 257SER B 311 | None | 1.11A | 3kpcA-3gztB:undetectable | 3kpcA-3gztB:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 5 | ILE A 258THR A 260ASP A 263THR A 284ILE A 288 | CMK A 1 (-4.2A)CMK A 1 (-3.4A)CMK A 1 (-2.8A)CMK A 1 (-3.1A)CMK A 1 (-3.7A) | 1.09A | 3kpcA-3k2vA:16.5 | 3kpcA-3k2vA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k3q | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | ILE B 45ASP B 49ILE B 135ASN B 26ILE B 24 | None | 1.25A | 3kpcA-3k3qB:undetectable | 3kpcA-3k3qB:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kf8 | PROTEIN TEN1 (Candidatropicalis) |
PF12658(Ten1) | 5 | ILE B 58ILE B 82ASN B 92ILE B 91PRO B 8 | None | 1.12A | 3kpcA-3kf8B:undetectable | 3kpcA-3kf8B:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 51THR A 53ASP A 56VAL A 94ASN A 114PRO A 119 | ADP A 283 ( 4.2A)ADP A 283 (-2.7A)ADP A 283 (-2.8A)ADP A 283 (-3.7A)ADP A 284 ( 4.9A)None | 0.47A | 3kpcA-3kh5A:12.7 | 3kpcA-3kh5A:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 51THR A 53ASP A 56VAL A 94ILE A 95PRO A 119 | ADP A 283 ( 4.2A)ADP A 283 (-2.7A)ADP A 283 (-2.8A)ADP A 283 (-3.7A)ADP A 283 (-3.8A)None | 0.52A | 3kpcA-3kh5A:12.7 | 3kpcA-3kh5A:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 7 | ILE A 193THR A 195ASP A 198VAL A 233ILE A 234ILE A 254PRO A 258 | AMP A 282 ( 4.3A)AMP A 282 (-3.1A)AMP A 282 (-3.1A)AMP A 282 (-3.8A)AMP A 282 (-3.9A)AMP A 282 (-4.1A)None | 0.55A | 3kpcA-3kh5A:12.7 | 3kpcA-3kh5A:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 269THR A 271ASP A 274THR A 155ASN A 114 | ADP A 284 ( 4.3A)ADP A 284 (-3.4A)ADP A 284 (-2.8A)ADP A 284 (-3.2A)ADP A 284 ( 4.9A) | 1.17A | 3kpcA-3kh5A:12.7 | 3kpcA-3kh5A:24.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 7 | ILE A 269THR A 271ASP A 274THR A 155VAL A 158ILE A 159PRO A 183 | ADP A 284 ( 4.3A)ADP A 284 (-3.4A)ADP A 284 (-2.8A)ADP A 284 (-3.2A)ADP A 284 (-3.9A)ADP A 284 (-4.2A)None | 0.29A | 3kpcA-3kh5A:12.7 | 3kpcA-3kh5A:24.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 10 | ILE A 434THR A 436ASP A 439THR A 456VAL A 459ILE A 460ASN A 479ILE A 480SER A 481PRO A 484 | SAM A1000 ( 4.2A)SAM A1000 (-3.4A)SAM A1000 (-2.6A)SAM A1000 (-3.0A)SAM A1000 ( 3.9A)SAM A1000 (-3.8A)NoneSAM A1000 (-4.0A)SAM A1000 (-3.2A)None | 0.75A | 3kpcA-3kpbA:21.3 | 3kpcA-3kpbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 7 | ILE A 495THR A 497ASP A 500ILE A 399ASN A 418ILE A 419PRO A 423 | None | 0.79A | 3kpcA-3kpbA:21.3 | 3kpcA-3kpbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldh | LACTATEDEHYDROGENASE (Squalusacanthias) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | THR A 25VAL A 95ILE A 96ASN A 126ILE A 127 | None | 1.26A | 3kpcA-3ldhA:undetectable | 3kpcA-3ldhA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocm | PUTATIVE MEMBRANEPROTEIN (Bordetellaparapertussis) |
PF00571(CBS) | 5 | THR A 443ASP A 446THR A 339VAL A 344PRO A 369 | ADP A 470 (-3.0A)ADP A 470 (-2.8A)ADP A 470 (-3.6A)ADP A 470 ( 4.0A)None | 0.66A | 3kpcA-3ocmA:10.6 | 3kpcA-3ocmA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oop | LIN2960 PROTEIN (Listeriainnocua) |
PF01047(MarR) | 5 | THR A 58VAL A 39ILE A 43ILE A 49SER A 50 | None | 1.20A | 3kpcA-3oopA:undetectable | 3kpcA-3oopA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqp | PUTATIVEISOCHORISMATASE (Paraburkholderiaxenovorans) |
PF00857(Isochorismatase) | 5 | ILE A 9THR A 125VAL A 51ILE A 52ASN A 55 | NoneNoneNoneNonePG4 A 302 (-3.2A) | 1.27A | 3kpcA-3oqpA:undetectable | 3kpcA-3oqpA:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pen | TRANSLATIONINITIATION FACTOR 2SUBUNIT GAMMA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 5 | ILE A 272THR A 274ILE A 316ILE A 238SER A 220 | None | 1.20A | 3kpcA-3penA:undetectable | 3kpcA-3penA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pr2 | TRYPTOPHAN SYNTHASEALPHA CHAIN (Salmonellaenterica) |
PF00290(Trp_syntA) | 5 | ILE A 64THR A 183THR A 63VAL A 238ILE A 237 | NoneF9F A 1 (-3.9A)NoneNoneNone | 1.26A | 3kpcA-3pr2A:undetectable | 3kpcA-3pr2A:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0s | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Campylobacterjejuni) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ILE A 52THR A 50ILE A 108ASN A 96ILE A 95 | None | 1.27A | 3kpcA-3r0sA:undetectable | 3kpcA-3r0sA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ILE A 65THR A 67VAL A 145ILE A 146ILE A 149 | None | 1.11A | 3kpcA-3ramA:undetectable | 3kpcA-3ramA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlz | MCCF (Escherichiacoli) |
PF02016(Peptidase_S66) | 5 | ILE A 107THR A 131VAL A 78ILE A 86ILE A 114 | None | 1.25A | 3kpcA-3tlzA:undetectable | 3kpcA-3tlzA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 6 | ILE A 137THR A 139ASP A 142ILE A 163ILE A 183PRO A 187 | None | 0.97A | 3kpcA-3tsdA:14.7 | 3kpcA-3tsdA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 487d | PROTEIN (50S L9RIBOSOMAL PROTEIN) (Geobacillusstearothermophilus) |
PF01281(Ribosomal_L9_N)PF03948(Ribosomal_L9_C) | 5 | ILE K 121THR K 127VAL K 145ILE K 98SER K 95 | None | 1.25A | 3kpcA-487dK:undetectable | 3kpcA-487dK:24.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4acz | ENDO-ALPHA-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF16317(Glyco_hydro_99) | 5 | THR B 218VAL B 172ILE B 171ILE B 168PRO B 188 | None | 1.24A | 3kpcA-4aczB:undetectable | 3kpcA-4aczB:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aey | D-ERYTHRO-7,8-DIHYDRONEOPTERINTRIPHOSPHATEEPIMERASE (Pseudomonasaeruginosa) |
PF02152(FolB) | 5 | ILE A 68THR A 64ILE A 86ASN A 38ILE A 37 | None | 1.07A | 3kpcA-4aeyA:undetectable | 3kpcA-4aeyA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | ILE A 359ASP A 364THR A 407ILE A 431PRO A 435 | None | 1.24A | 3kpcA-4esyA:14.0 | 3kpcA-4esyA:29.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | ILE A 359THR A 361ASP A 364THR A 407ILE A 431 | None | 1.03A | 3kpcA-4esyA:14.0 | 3kpcA-4esyA:29.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fry | PUTATIVESIGNAL-TRANSDUCTIONPROTEIN WITH CBSDOMAINS (Burkholderiaambifaria) |
PF00571(CBS) | 6 | ILE A 54THR A 56ASP A 59THR A 81VAL A 84PRO A 109 | AMP A 202 (-4.1A)AMP A 202 (-2.9A)AMP A 202 (-2.6A)AMP A 202 (-3.6A)AMP A 202 (-3.8A)AMP A 202 (-4.7A) | 0.37A | 3kpcA-4fryA:17.4 | 3kpcA-4fryA:28.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnx | PUTATIVEUNCHARACTERIZEDPROTEIN (Ustilago maydis) |
PF01336(tRNA_anti-codon)PF08646(Rep_fac-A_C)PF16900(REPA_OB_2) | 5 | ILE C 255THR C 282ILE C 231ASN C 261ILE C 276 | None | 1.12A | 3kpcA-4gnxC:undetectable | 3kpcA-4gnxC:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iys | METAL TRANSPORTERCNNM2 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 566THR A 568ASP A 571THR A 451PRO A 482 | None | 0.83A | 3kpcA-4iysA:12.1 | 3kpcA-4iysA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 5 | ASP A 454VAL A 116ILE A 117ASN A 95ILE A 96 | None | 1.26A | 3kpcA-4j9uA:undetectable | 3kpcA-4j9uA:12.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kgk | THG1-LIKEUNCHARACTERIZEDPROTEIN (Bacillusthuringiensis) |
PF04446(Thg1) | 5 | ILE A 100VAL A 27ILE A 79ASN A 63ILE A 64 | None | 1.18A | 3kpcA-4kgkA:undetectable | 3kpcA-4kgkA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lb8 | UNCHARACTERIZEDPROTEIN (Bacteroidesthetaiotaomicron) |
PF16140(DUF4848) | 5 | ILE A 291THR A 290VAL A 308ILE A 189SER A 184 | None | 1.18A | 3kpcA-4lb8A:undetectable | 3kpcA-4lb8A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nho | PROBABLEATP-DEPENDENT RNAHELICASE DDX23 (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | THR A 381VAL A 626ILE A 431ILE A 424PRO A 624 | None | 1.24A | 3kpcA-4nhoA:undetectable | 3kpcA-4nhoA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9k | ARABINOSE5-PHOSPHATEISOMERASE (Methylococcuscapsulatus) |
PF00571(CBS) | 5 | THR A 256ASP A 259THR A 280ILE A 304PRO A 308 | CMK A 401 (-3.4A)CMK A 401 (-2.6A)CMK A 401 (-3.1A)CMK A 401 (-3.5A)CMK A 401 (-4.5A) | 0.69A | 3kpcA-4o9kA:17.8 | 3kpcA-4o9kA:28.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6v | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT F (Vibrio cholerae) |
PF00111(Fer2)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | ILE F 279VAL F 387ILE F 388ASN F 400ILE F 401 | None | 1.26A | 3kpcA-4p6vF:undetectable | 3kpcA-4p6vF:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r85 | CYTOSINE DEAMINASE (Klebsiellapneumoniae) |
PF07969(Amidohydro_3) | 5 | ILE A 57THR A 62THR A 116VAL A 114ILE A 103 | None | 1.26A | 3kpcA-4r85A:undetectable | 3kpcA-4r85A:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rer | 5'-AMP-ACTIVATEDPROTEIN KINASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00571(CBS) | 5 | ILE G 312ASP G 317THR G 200SER G 226PRO G 229 | AMP G 403 (-3.6A)AMP G 403 (-2.9A)AMP G 403 (-3.5A)AMP G 403 (-2.3A)None | 0.72A | 3kpcA-4rerG:11.2 | 3kpcA-4rerG:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9u | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT F (Vibrio cholerae) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | ILE A 279VAL A 387ILE A 388ASN A 400ILE A 401 | None | 1.26A | 3kpcA-4u9uA:undetectable | 3kpcA-4u9uA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wfs | TRNA-DIHYDROURIDINE(20) SYNTHASE[NAD(P)+]-LIKE (Homo sapiens) |
PF01207(Dus) | 5 | ILE A 203THR A 165VAL A 169ILE A 172ILE A 156 | None | 1.14A | 3kpcA-4wfsA:undetectable | 3kpcA-4wfsA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9q | SUPEROXIDE DISMUTASE[MN] 2,MITOCHONDRIAL (Caenorhabditiselegans) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | ILE A 96THR A 95ASP A 99ILE A 185PRO A 88 | None | 1.26A | 3kpcA-4x9qA:undetectable | 3kpcA-4x9qA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awe | PUTATIVE ACETOINUTILIZATION PROTEIN,ACETOINDEHYDROGENASE (Thermusthermophilus) |
PF00571(CBS) | 5 | ILE A 120THR A 122ASP A 125THR A 8PRO A 36 | None | 0.66A | 3kpcA-5aweA:12.5 | 3kpcA-5aweA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awe | PUTATIVE ACETOINUTILIZATION PROTEIN,ACETOINDEHYDROGENASE (Thermusthermophilus) |
PF00571(CBS) | 5 | THR A 48ASP A 51VAL A 85ILE A 106PRO A 110 | None | 0.58A | 3kpcA-5aweA:12.5 | 3kpcA-5aweA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ccx | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASENON-CATALYTICSUBUNIT TRM6 (Homo sapiens) |
PF04189(Gcd10p) | 5 | ILE B 227VAL B 205ILE B 373ASN B 196ILE B 197 | None | 1.09A | 3kpcA-5ccxB:undetectable | 3kpcA-5ccxB:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e53 | CONTACTIN-1 (Gallus gallus) |
PF00041(fn3) | 5 | ILE A 833THR A 857VAL A 818ILE A 816ASN A 861 | None | 1.25A | 3kpcA-5e53A:undetectable | 3kpcA-5e53A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ew5 | COLICIN-E9 (Escherichiacoli) |
PF03515(Cloacin) | 5 | THR A 268VAL A 288ILE A 156ASN A 196ILE A 197 | None | 1.18A | 3kpcA-5ew5A:undetectable | 3kpcA-5ew5A:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g49 | NUCLEARTRANSCRIPTION FACTORY SUBUNIT B-6NUCLEARTRANSCRIPTION FACTORY SUBUNIT C-3 (Arabidopsisthaliana;Arabidopsisthaliana) |
PF00808(CBFD_NFYB_HMF)PF00808(CBFD_NFYB_HMF) | 5 | ILE A 90THR B 109ILE A 69ILE A 82SER A 83 | NoneNoneNoneNoneACT B1152 (-2.7A) | 1.20A | 3kpcA-5g49A:undetectable | 3kpcA-5g49A:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5x | SITE-2 PROTEASE (Archaeoglobusfulgidus) |
PF00571(CBS) | 6 | ILE A 277THR A 279ASP A 282VAL A 300ILE A 321PRO A 325 | ATP A1355 (-4.1A)ATP A1355 (-2.4A)ATP A1355 (-1.9A)ATP A1355 (-3.8A)ATP A1355 (-4.5A)None | 0.58A | 3kpcA-5g5xA:17.7 | 3kpcA-5g5xA:29.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzp | TRIOSEPHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF00121(TIM) | 5 | ILE A 204ASP A 227VAL A 192ILE A 191ILE A 188 | None | 1.19A | 3kpcA-5gzpA:undetectable | 3kpcA-5gzpA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hd2 | PARASPORAL CRYSTALPROTEIN (Bacillusthuringiensis) |
PF03318(ETX_MTX2) | 5 | ILE A 3THR A 103ASP A 5ILE A 108SER A 109 | None | 1.19A | 3kpcA-5hd2A:undetectable | 3kpcA-5hd2A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jcf | MELANOMADIFFERENTIATIONASSOCIATED PROTEIN-5 (Gallus gallus) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | ILE A 501THR A 440ILE A 510ASN A 317PRO A 483 | None | 1.25A | 3kpcA-5jcfA:undetectable | 3kpcA-5jcfA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltm | PHENYLALANINEAMMONIA LYASE (Anabaena) |
no annotation | 5 | ILE B 77THR B 81ILE B 350ILE B 67PRO B 348 | None | 1.27A | 3kpcA-5ltmB:undetectable | 3kpcA-5ltmB:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc3 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Eremotheciumgossypii) |
PF00478(IMPDH)PF00571(CBS) | 7 | ILE A 163THR A 165ASP A 168THR A 184VAL A 187ILE A 188PRO A 212 | ATP A 601 ( 4.6A)ATP A 601 (-2.7A)ATP A 601 (-2.3A)ATP A 601 (-2.8A)ATP A 601 (-4.0A)ATP A 601 (-4.2A)ATP A 601 ( 4.9A) | 0.45A | 3kpcA-5tc3A:14.5 | 3kpcA-5tc3A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ywz | SUNDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
no annotation | 5 | ILE A 719VAL A 708ILE A 707ASN A 730ILE A 727 | None | 1.14A | 3kpcA-5ywzA:undetectable | 3kpcA-5ywzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6caa | ELECTROGENIC SODIUMBICARBONATECOTRANSPORTER 1 (Homo sapiens) |
no annotation | 5 | ASP A 754VAL A 802ILE A 805ASN A 763ILE A 761 | None | 1.26A | 3kpcA-6caaA:undetectable | 3kpcA-6caaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6v | TELOMERASEHOLOENZYME TEB2SUBUNIT (Tetrahymenathermophila) |
no annotation | 5 | VAL E 99ILE E 100ILE E 85SER E 78PRO E 83 | None | 1.10A | 3kpcA-6d6vE:undetectable | 3kpcA-6d6vE:undetectable |