SIMILAR PATTERNS OF AMINO ACIDS FOR 3KPB_D_SAMD1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo6 ESTROGEN
SULFOTRANSFERASE


(Mus musculus)
PF00685
(Sulfotransfer_1)
5 ILE A  75
THR A  52
TRP A  53
ILE A 104
ILE A  43
None
A3P  A 301 (-3.7A)
A3P  A 301 (-3.5A)
None
None
1.38A 3kpbD-1bo6A:
undetectable
3kpbD-1bo6A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN


(Sphingomonas
paucimobilis)
PF02900
(LigB)
5 ILE B 248
VAL B  57
ILE B  55
ILE B 172
SER B 171
None
1.40A 3kpbD-1bouB:
undetectable
3kpbD-1bouB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE


(Bacillus
megaterium)
PF00590
(TP_methylase)
5 TRP A 247
THR A 150
VAL A 153
ILE A 154
ILE A 180
None
1.22A 3kpbD-1cbfA:
undetectable
3kpbD-1cbfA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1)
PF00082
(Peptidase_S8)
5 ILE A  90
ASP A  48
VAL A 211
ILE A 210
ILE A  79
None
CA  A 701 (-2.2A)
None
None
None
1.42A 3kpbD-1dbiA:
undetectable
3kpbD-1dbiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3m ESTROGEN
SULFOTRANSFERASE


(Homo sapiens)
PF00685
(Sulfotransfer_1)
5 ILE A  74
THR A  51
TRP A  52
ILE A 103
ILE A  42
None
A3P  A 701 (-3.6A)
A3P  A 701 (-3.4A)
None
None
1.46A 3kpbD-1g3mA:
undetectable
3kpbD-1g3mA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hk7 HEAT SHOCK PROTEIN
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
5 ILE A 474
THR A 525
ASP A 523
THR A 475
VAL A 482
None
1.43A 3kpbD-1hk7A:
undetectable
3kpbD-1hk7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR


(Escherichia
coli)
PF03466
(LysR_substrate)
5 ILE A  98
THR A 129
ASP A 196
THR A 100
ILE A 268
None
1.38A 3kpbD-1i6aA:
undetectable
3kpbD-1i6aA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE


(Arabidopsis
thaliana)
PF01053
(Cys_Met_Meta_PP)
5 ILE A 239
TRP A 222
THR A 204
VAL A 210
ILE A 214
None
1.41A 3kpbD-1ibjA:
undetectable
3kpbD-1ibjA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803)
PF00497
(SBP_bac_3)
5 ILE A  73
VAL A 193
ILE A  68
ILE A  70
SER A  31
None
1.30A 3kpbD-1iiwA:
undetectable
3kpbD-1iiwA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
5 THR A 139
ASP A 142
LYS A 145
ILE A 129
SER A  36
None
1.34A 3kpbD-1izeA:
undetectable
3kpbD-1izeA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001


(Methanothermobacter
thermautotrophicus)
PF02598
(Methyltrn_RNA_3)
5 ILE A  57
THR A  15
VAL A  28
ILE A  31
ILE A  10
None
1.14A 3kpbD-1k3rA:
undetectable
3kpbD-1k3rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjo DIHYDROLIPOAMIDE
ACETYLTRANSFERASE


(Escherichia
coli)
PF00364
(Biotin_lipoyl)
5 ILE A  10
ASP A   9
VAL A  37
ILE A  35
ILE A  71
None
1.31A 3kpbD-1qjoA:
undetectable
3kpbD-1qjoA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3


(Bos taurus)
PF00022
(Actin)
5 ILE A 168
THR A 326
THR A 175
VAL A 177
ILE A 178
None
1.34A 3kpbD-1u2vA:
undetectable
3kpbD-1u2vA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usv HEAT SHOCK PROTEIN
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
5 ILE A 474
THR A 525
ASP A 523
THR A 475
VAL A 482
None
1.30A 3kpbD-1usvA:
undetectable
3kpbD-1usvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE


(Clostridium
acetobutylicum)
PF04029
(2-ph_phosp)
5 ILE A 133
THR A  21
VAL A 166
ILE A 163
ILE A 142
None
1.30A 3kpbD-1vr0A:
undetectable
3kpbD-1vr0A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xkf HYPOTHETICAL PROTEIN
RV2626C


(Mycobacterium
tuberculosis)
PF00571
(CBS)
5 ILE A 113
THR A 115
ASP A 118
VAL A  12
ILE A  33
None
0.93A 3kpbD-1xkfA:
16.7
3kpbD-1xkfA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A 139
THR A 141
ASP A 144
THR A 160
ILE A 185
None
0.90A 3kpbD-1zfjA:
15.8
3kpbD-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)


(Mycobacterium
tuberculosis)
PF00484
(Pro_CA)
5 THR A 160
VAL A 101
ILE A  99
ILE A  87
SER A  86
None
1.34A 3kpbD-2a5vA:
undetectable
3kpbD-2a5vA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE


(Bacillus
megaterium)
PF00590
(TP_methylase)
5 TRP A 247
THR A 150
VAL A 153
ILE A 154
ILE A 180
None
1.28A 3kpbD-2cbfA:
undetectable
3kpbD-2cbfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A


(Aquifex
aeolicus)
PF12804
(NTP_transf_3)
5 THR A 136
TRP A 161
ILE A 149
ILE A  85
SER A  84
None
1.13A 3kpbD-2e8bA:
undetectable
3kpbD-2e8bA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ef7 HYPOTHETICAL PROTEIN
ST2348


(Sulfurisphaera
tokodaii)
PF00571
(CBS)
6 ILE A  49
THR A  51
ASP A  54
LYS A  57
THR A  74
ILE A  98
None
1.10A 3kpbD-2ef7A:
14.6
3kpbD-2ef7A:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE


(Lactobacillus
casei)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 THR A 422
VAL A 419
ILE A 312
ILE A 304
SER A 305
None
1.32A 3kpbD-2gcaA:
undetectable
3kpbD-2gcaA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I


(Schizosaccharomyces
pombe)
no annotation 5 ILE G 303
ASP G 308
THR G 191
ILE G 216
SER G 217
AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
0.59A 3kpbD-2ooxG:
11.2
3kpbD-2ooxG:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6


(Homo sapiens)
PF00481
(PP2C)
5 TRP A 274
THR A 278
ILE A 245
ILE A 290
SER A  27
None
None
OCS  A 242 ( 4.1A)
None
None
1.41A 3kpbD-2p8eA:
undetectable
3kpbD-2p8eA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A 124
THR A  15
VAL A  18
ILE A  19
ILE A  39
None
0.68A 3kpbD-2p9mA:
17.5
3kpbD-2p9mA:
37.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc3 CBS DOMAIN

(Nitrosomonas
europaea)
PF00571
(CBS)
6 ILE A  72
THR A  74
ASP A  77
LYS A  81
THR A  99
VAL A 102
None
BR  A 171 (-4.0A)
None
None
BR  A 177 ( 4.2A)
None
0.83A 3kpbD-2rc3A:
17.7
3kpbD-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re7 UNCHARACTERIZED
PROTEIN


(Psychrobacter
arcticus)
PF16242
(Pyrid_ox_like)
5 ILE A  68
VAL A 122
ILE A  48
ILE A  83
SER A  82
None
1.18A 3kpbD-2re7A:
undetectable
3kpbD-2re7A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780


(Pyrococcus
horikoshii)
PF00571
(CBS)
6 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
0.63A 3kpbD-2yzqA:
15.8
3kpbD-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 BCLA PROTEIN

(Bacillus
anthracis)
no annotation 5 ILE A 136
THR A 180
ILE A 118
ILE A 128
SER A 187
None
1.27A 3kpbD-3ab0A:
undetectable
3kpbD-3ab0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404


(Pyrococcus
horikoshii)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 ILE A 189
ASP A 334
THR A 209
ILE A 191
ILE A 362
None
1.18A 3kpbD-3af5A:
undetectable
3kpbD-3af5A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus)
PF00089
(Trypsin)
5 ILE A 212
ASP A 102
THR A 229
ILE A 123
ILE A 238
None
1.43A 3kpbD-3beuA:
undetectable
3kpbD-3beuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clv RAB5 PROTEIN,
PUTATIVE


(Plasmodium
falciparum)
PF00071
(Ras)
PF08477
(Roc)
5 ILE A  97
THR A  10
VAL A  24
ILE A  23
ILE A 194
None
1.31A 3kpbD-3clvA:
undetectable
3kpbD-3clvA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyq CHEMOTAXIS PROTEIN
MOTB


(Helicobacter
pylori)
no annotation 5 ILE B 241
THR B 233
ASP B 237
ILE B 148
ILE B 157
None
1.47A 3kpbD-3cyqB:
undetectable
3kpbD-3cyqB:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR


(Homo sapiens)
PF00041
(fn3)
5 THR A 261
VAL A 209
ILE A 210
ILE A 253
SER A 254
None
None
None
None
FUC  A 492 ( 3.8A)
1.27A 3kpbD-3e0gA:
undetectable
3kpbD-3e0gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE


(Bacillus
subtilis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 ILE A  93
THR A  91
VAL A  71
ILE A   6
ILE A  62
None
1.13A 3kpbD-3egoA:
undetectable
3kpbD-3egoA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN


(Geobacillus
kaustophilus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
5 THR A 378
THR A 349
VAL A 360
ILE A 364
ILE A 375
None
1.42A 3kpbD-3f2bA:
undetectable
3kpbD-3f2bA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhm UNCHARACTERIZED
PROTEIN ATU1752


(Agrobacterium
fabrum)
PF00571
(CBS)
5 ILE A  52
THR A  54
ASP A  57
THR A  79
VAL A  82
AMP  A 200 (-4.0A)
AMP  A 200 (-2.9A)
AMP  A 200 (-2.9A)
AMP  A 200 (-3.5A)
AMP  A 200 ( 4.3A)
0.39A 3kpbD-3fhmA:
16.4
3kpbD-3fhmA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00571
(CBS)
5 ILE A 259
THR A 261
ASP A 264
THR A 285
ILE A 289
AMP  A 401 (-4.8A)
AMP  A 401 (-3.1A)
AMP  A 401 (-2.7A)
AMP  A 401 (-3.1A)
None
0.95A 3kpbD-3fnaA:
15.2
3kpbD-3fnaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00571
(CBS)
7 ILE A 259
THR A 261
ASP A 264
THR A 285
ILE A 289
ILE A 309
SER A 311
AMP  A 401 (-4.8A)
AMP  A 401 (-3.1A)
AMP  A 401 (-2.7A)
AMP  A 401 (-3.1A)
None
AMP  A 401 (-4.4A)
None
1.35A 3kpbD-3fnaA:
15.2
3kpbD-3fnaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg2 SUGAR DEHYDROGENASE,
UDP-GLUCOSE/GDP-MANN
OSE DEHYDROGENASE
FAMILY


(Porphyromonas
gingivalis)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 ILE A 160
THR A 196
ILE A 158
ILE A 184
SER A 183
None
1.46A 3kpbD-3gg2A:
undetectable
3kpbD-3gg2A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE


(Bacillus
anthracis)
PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 235
THR A 180
THR A 237
VAL A 227
ILE A 159
None
1.39A 3kpbD-3icsA:
undetectable
3kpbD-3icsA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE


(Klebsiella
pneumoniae)
PF00571
(CBS)
5 ILE A 258
THR A 260
ASP A 263
THR A 284
ILE A 288
CMK  A   1 (-4.2A)
CMK  A   1 (-3.4A)
CMK  A   1 (-2.8A)
CMK  A   1 (-3.1A)
CMK  A   1 (-3.7A)
0.95A 3kpbD-3k2vA:
15.4
3kpbD-3k2vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE


(Klebsiella
pneumoniae)
PF00571
(CBS)
6 ILE A 258
THR A 260
ASP A 263
THR A 284
ILE A 288
ILE A 308
CMK  A   1 (-4.2A)
CMK  A   1 (-3.4A)
CMK  A   1 (-2.8A)
CMK  A   1 (-3.1A)
CMK  A   1 (-3.7A)
CMK  A   1 (-3.7A)
0.83A 3kpbD-3k2vA:
15.4
3kpbD-3k2vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A  51
THR A  53
ASP A  56
VAL A  94
ILE A  95
ADP  A 283 ( 4.2A)
ADP  A 283 (-2.7A)
ADP  A 283 (-2.8A)
ADP  A 283 (-3.7A)
ADP  A 283 (-3.8A)
0.31A 3kpbD-3kh5A:
12.9
3kpbD-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
6 ILE A 193
THR A 195
ASP A 198
LYS A 201
VAL A 233
ILE A 234
AMP  A 282 ( 4.3A)
AMP  A 282 (-3.1A)
AMP  A 282 (-3.1A)
AMP  A 282 ( 3.7A)
AMP  A 282 (-3.8A)
AMP  A 282 (-3.9A)
0.91A 3kpbD-3kh5A:
12.9
3kpbD-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
6 ILE A 193
THR A 195
ASP A 198
VAL A 233
ILE A 234
ILE A 254
AMP  A 282 ( 4.3A)
AMP  A 282 (-3.1A)
AMP  A 282 (-3.1A)
AMP  A 282 (-3.8A)
AMP  A 282 (-3.9A)
AMP  A 282 (-4.1A)
0.39A 3kpbD-3kh5A:
12.9
3kpbD-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
7 ILE A 269
THR A 271
ASP A 274
LYS A 277
THR A 155
VAL A 158
ILE A 159
ADP  A 284 ( 4.3A)
ADP  A 284 (-3.4A)
ADP  A 284 (-2.8A)
ADP  A 284 (-3.5A)
ADP  A 284 (-3.2A)
ADP  A 284 (-3.9A)
ADP  A 284 (-4.2A)
0.58A 3kpbD-3kh5A:
12.9
3kpbD-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)


(Clostridium
acetobutylicum)
PF07992
(Pyr_redox_2)
5 ILE A  82
THR A 233
ASP A 232
VAL A  89
ILE A 104
None
1.47A 3kpbD-3kljA:
undetectable
3kpbD-3kljA:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
10 ILE A 434
THR A 436
TRP A 438
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
ILE A 480
SER A 481
SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
0.22A 3kpbD-3kpbA:
24.0
3kpbD-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A 495
THR A 497
ASP A 500
ILE A 399
ILE A 419
None
0.66A 3kpbD-3kpbA:
24.0
3kpbD-3kpbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE


(Ruegeria sp.
TM1040)
PF04952
(AstE_AspA)
5 ILE A  43
THR A  41
THR A  75
VAL A  80
ILE A 237
None
1.36A 3kpbD-3na6A:
undetectable
3kpbD-3na6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Clostridium
perfringens)
PF14010
(PEPcase_2)
5 ILE A  47
VAL A  79
ILE A 117
ILE A 101
SER A  97
None
1.43A 3kpbD-3odmA:
undetectable
3kpbD-3odmA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oop LIN2960 PROTEIN

(Listeria
innocua)
PF01047
(MarR)
5 THR A  58
VAL A  39
ILE A  43
ILE A  49
SER A  50
None
1.21A 3kpbD-3oopA:
undetectable
3kpbD-3oopA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA


(Sulfolobus
solfataricus)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
5 ILE A 272
THR A 274
ILE A 316
ILE A 238
SER A 220
None
1.22A 3kpbD-3penA:
undetectable
3kpbD-3penA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN


(Bacillus
subtilis)
PF04069
(OpuAC)
5 ILE A  55
THR A  63
VAL A 261
ILE A 262
ILE A  86
None
1.15A 3kpbD-3ppoA:
undetectable
3kpbD-3ppoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A  65
THR A  67
VAL A 145
ILE A 146
ILE A 149
None
1.11A 3kpbD-3ramA:
undetectable
3kpbD-3ramA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli)
PF02016
(Peptidase_S66)
5 ILE A 107
THR A 131
VAL A  78
ILE A  86
ILE A 114
None
1.30A 3kpbD-3tlzA:
undetectable
3kpbD-3tlzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgs NUCLEOSIDE
DIPHOSPHATE KINASE


(Halomonas sp.
#593)
PF00334
(NDK)
5 ILE A 103
ASP A 106
VAL A 116
ILE A  10
SER A  25
None
1.40A 3kpbD-3vgsA:
undetectable
3kpbD-3vgsA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN


(Xenopus laevis)
no annotation 5 ILE B 386
ASP B 390
VAL B 146
ILE B 145
ILE B 370
None
1.37A 3kpbD-3w0lB:
undetectable
3kpbD-3w0lB:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
487d PROTEIN (50S L9
RIBOSOMAL PROTEIN)


(Geobacillus
stearothermophilus)
PF01281
(Ribosomal_L9_N)
PF03948
(Ribosomal_L9_C)
5 ILE K 121
THR K 127
VAL K 145
ILE K  98
SER K  95
None
1.33A 3kpbD-487dK:
undetectable
3kpbD-487dK:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE


(Pyrococcus
abyssi)
PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1)
5 ILE A 177
VAL A 147
ILE A 154
ILE A 169
SER A 170
None
1.32A 3kpbD-4a8eA:
undetectable
3kpbD-4a8eA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 ILE A  65
THR A  53
TRP A  90
VAL A  85
SER A  74
None
1.45A 3kpbD-4egeA:
undetectable
3kpbD-4egeA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esy CBS DOMAIN
CONTAINING MEMBRANE
PROTEIN


(Sphaerobacter
thermophilus)
PF00571
(CBS)
5 ILE A 359
THR A 361
ASP A 364
THR A 407
ILE A 431
None
1.09A 3kpbD-4esyA:
14.9
3kpbD-4esyA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS


(Burkholderia
ambifaria)
PF00571
(CBS)
6 ILE A  54
THR A  56
ASP A  59
LYS A  63
THR A  81
VAL A  84
AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 ( 4.1A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
0.69A 3kpbD-4fryA:
16.2
3kpbD-4fryA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B


(Clostridium
perfringens)
PF07968
(Leukocidin)
5 ILE A 142
THR A 189
ILE A 137
ILE A 180
SER A 181
None
1.30A 3kpbD-4i0nA:
undetectable
3kpbD-4i0nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4k UNCHARACTERIZED
PROTEIN SGCJ


(Streptomyces
globisporus)
PF14534
(DUF4440)
5 ILE A 100
THR A  75
VAL A  77
ILE A  78
SER A 109
None
None
PG4  A 202 (-4.7A)
None
None
1.43A 3kpbD-4i4kA:
undetectable
3kpbD-4i4kA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE


(Plasmodium
falciparum)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
5 LYS A1044
THR A 576
VAL A 579
ILE A 563
SER A 649
None
1.27A 3kpbD-4j3bA:
undetectable
3kpbD-4j3bA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4b PYLD

(Methanosarcina
barkeri)
no annotation 5 ILE A 132
THR A  27
VAL A  23
ILE A  31
SER A 253
None
1.39A 3kpbD-4j4bA:
undetectable
3kpbD-4j4bA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE


(Nocardia
farcinica)
PF00067
(p450)
5 ILE A 220
ASP A 214
THR A 216
VAL A 234
ILE A 235
None
1.45A 3kpbD-4j6cA:
undetectable
3kpbD-4j6cA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN


(Arabidopsis
thaliana)
PF12697
(Abhydrolase_6)
5 ILE A 241
VAL A 259
ILE A 260
ILE A 118
SER A 119
None
1.42A 3kpbD-4jypA:
undetectable
3kpbD-4jypA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II


(Acidothermus
cellulolyticus)
no annotation 5 ILE A 421
ASP A 409
THR A 407
ILE A 328
ILE A 341
None
1.34A 3kpbD-4lgnA:
undetectable
3kpbD-4lgnA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mct ANTIDOTE PROTEIN

(Proteus
vulgaris)
PF01381
(HTH_3)
5 THR A  37
VAL A  33
ILE A  31
ILE A  56
SER A  53
None
1.46A 3kpbD-4mctA:
undetectable
3kpbD-4mctA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE


(Staphylococcus
aureus)
PF02423
(OCD_Mu_crystall)
5 ILE A 150
THR A 123
ILE A 144
ILE A 211
SER A 233
GOL  A 402 (-3.9A)
SO4  A 401 ( 4.4A)
None
None
None
1.34A 3kpbD-4mp3A:
undetectable
3kpbD-4mp3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN


(Sulfolobus
acidocaldarius)
PF01266
(DAO)
5 ILE A  11
THR A 157
VAL A 153
ILE A 283
SER A 165
None
FDA  A 501 (-3.8A)
None
None
None
1.33A 3kpbD-4opuA:
undetectable
3kpbD-4opuA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmj PUTATIVE
OXIDOREDUCTASE


(Sinorhizobium
meliloti)
PF00248
(Aldo_ket_red)
5 ILE A  51
THR A  53
VAL A  66
ILE A  65
SER A  39
None
1.40A 3kpbD-4pmjA:
undetectable
3kpbD-4pmjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore)
5 ASP A1350
VAL A1085
ILE A1084
ILE A1346
SER A1325
None
1.27A 3kpbD-4r04A:
undetectable
3kpbD-4r04A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR


(Bacillus
anthracis)
PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11)
5 ILE A 408
VAL A 396
ILE A 444
ILE A 459
SER A 460
None
1.44A 3kpbD-4r6iA:
undetectable
3kpbD-4r6iA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa0 POSSIBLE ADHESIN

(Caldicellulosiruptor
kronotskyensis)
no annotation 5 ILE A 428
ASP A 424
THR A 427
ILE A 438
SER A 441
None
1.34A 3kpbD-4wa0A:
undetectable
3kpbD-4wa0A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
5 THR A  81
TRP A 860
ASP A 829
THR A 827
SER A 172
None
1.46A 3kpbD-4zgvA:
undetectable
3kpbD-4zgvA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zps MCG133388, ISOFORM
CRA_M


(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
5 ILE A   2
VAL A  90
ILE A  79
ILE A  19
SER A  20
None
1.43A 3kpbD-4zpsA:
undetectable
3kpbD-4zpsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF01008
(IF-2B)
PF01008
(IF-2B)
5 ILE C 230
THR C 257
VAL C 271
ILE G 122
SER G 121
None
1.31A 3kpbD-5b04C:
undetectable
3kpbD-5b04C:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2)
5 ILE A 356
ASP A 360
LYS A 364
ILE A 377
ILE A 391
None
1.35A 3kpbD-5bxpA:
undetectable
3kpbD-5bxpA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
PF01740
(STAS)
5 ILE A 249
THR A 245
VAL A 292
ILE A  74
SER A  75
None
1.16A 3kpbD-5da0A:
undetectable
3kpbD-5da0A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5x SITE-2 PROTEASE

(Archaeoglobus
fulgidus)
PF00571
(CBS)
5 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
0.62A 3kpbD-5g5xA:
17.3
3kpbD-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE


(Bacillus cereus)
PF00171
(Aldedh)
5 ILE A 252
THR A 248
VAL A 232
ILE A 231
ILE A 164
None
NAD  A 501 (-3.2A)
None
None
NAD  A 501 (-4.3A)
1.31A 3kpbD-5gtkA:
undetectable
3kpbD-5gtkA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii)
no annotation 5 THR A 695
VAL A 632
ILE A 634
ILE A 683
SER A 682
None
1.26A 3kpbD-5h7jA:
undetectable
3kpbD-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN


(Bacillus
thuringiensis)
PF03318
(ETX_MTX2)
5 THR A  41
VAL A  10
ILE A  14
ILE A  34
SER A  35
None
1.47A 3kpbD-5hd2A:
undetectable
3kpbD-5hd2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
5 ILE A 249
THR A 245
VAL A 292
ILE A  74
SER A  75
None
1.16A 3kpbD-5iofA:
undetectable
3kpbD-5iofA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN


(Thermothelomyces
thermophila)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
5 ILE A 296
THR A 291
VAL A 329
ILE A 330
ILE A 311
None
1.46A 3kpbD-5jxrA:
undetectable
3kpbD-5jxrA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION


(Homo sapiens)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2)
5 ILE B1771
TRP B1835
VAL B1773
ILE B1790
SER B1791
None
1.37A 3kpbD-5k8dB:
undetectable
3kpbD-5k8dB:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2


(Rattus
norvegicus)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
5 ILE A 284
THR A 282
VAL A 155
ILE A 156
ILE A 231
None
1.28A 3kpbD-5l2eA:
undetectable
3kpbD-5l2eA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN


(Thermotoga
maritima)
PF01926
(MMR_HSR1)
5 ILE A 168
THR A 164
VAL A 119
ILE A  93
ILE A  12
None
1.33A 3kpbD-5ladA:
undetectable
3kpbD-5ladA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muw PACKAGING ENZYME P4

(Pseudomonas
virus phi6)
PF11602
(NTPase_P4)
5 ILE A 172
THR A  73
ILE A 146
ILE A 164
SER A 165
None
1.26A 3kpbD-5muwA:
undetectable
3kpbD-5muwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa)
no annotation 5 ILE A  52
THR A  54
ASP A  57
LYS A  61
ILE A 103
None
0.83A 3kpbD-5nvdA:
14.6
3kpbD-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa)
no annotation 5 ILE A 117
ASP A 122
LYS A 126
THR A  12
VAL A  15
None
0.90A 3kpbD-5nvdA:
14.6
3kpbD-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Eremothecium
gossypii)
PF00478
(IMPDH)
PF00571
(CBS)
6 ILE A 163
THR A 165
ASP A 168
THR A 184
VAL A 187
ILE A 188
ATP  A 601 ( 4.6A)
ATP  A 601 (-2.7A)
ATP  A 601 (-2.3A)
ATP  A 601 (-2.8A)
ATP  A 601 (-4.0A)
ATP  A 601 (-4.2A)
0.52A 3kpbD-5tc3A:
14.8
3kpbD-5tc3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN
SECURIN


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF03568
(Peptidase_C50)
PF04856
(Securin)
5 THR A1567
THR A1231
VAL A1236
ILE A1240
ILE B 259
None
1.31A 3kpbD-5u1sA:
undetectable
3kpbD-5u1sA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 TRP A 252
THR A 137
VAL A 135
ILE A 167
SER A 186
None
1.17A 3kpbD-5vniA:
undetectable
3kpbD-5vniA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woy PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Caldanaerobacter
subterraneus)
no annotation 5 ILE A 137
THR A  50
VAL A 104
ILE A  86
SER A  81
None
1.36A 3kpbD-5woyA:
undetectable
3kpbD-5woyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Staphylococcus
aureus)
no annotation 5 ILE A 465
THR A 429
ILE A 416
ILE A 442
SER A 441
None
1.46A 3kpbD-5yh5A:
undetectable
3kpbD-5yh5A:
undetectable