SIMILAR PATTERNS OF AMINO ACIDS FOR 3KPB_D_SAMD1000
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bo6 | ESTROGENSULFOTRANSFERASE (Mus musculus) |
PF00685(Sulfotransfer_1) | 5 | ILE A 75THR A 52TRP A 53ILE A 104ILE A 43 | NoneA3P A 301 (-3.7A)A3P A 301 (-3.5A)NoneNone | 1.38A | 3kpbD-1bo6A:undetectable | 3kpbD-1bo6A:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 5 | ILE B 248VAL B 57ILE B 55ILE B 172SER B 171 | None | 1.40A | 3kpbD-1bouB:undetectable | 3kpbD-1bouB:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cbf | COBALT-PRECORRIN-4TRANSMETHYLASE (Bacillusmegaterium) |
PF00590(TP_methylase) | 5 | TRP A 247THR A 150VAL A 153ILE A 154ILE A 180 | None | 1.22A | 3kpbD-1cbfA:undetectable | 3kpbD-1cbfA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbi | AK.1 SERINE PROTEASE (Bacillus sp.Ak1) |
PF00082(Peptidase_S8) | 5 | ILE A 90ASP A 48VAL A 211ILE A 210ILE A 79 | None CA A 701 (-2.2A)NoneNoneNone | 1.42A | 3kpbD-1dbiA:undetectable | 3kpbD-1dbiA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g3m | ESTROGENSULFOTRANSFERASE (Homo sapiens) |
PF00685(Sulfotransfer_1) | 5 | ILE A 74THR A 51TRP A 52ILE A 103ILE A 42 | NoneA3P A 701 (-3.6A)A3P A 701 (-3.4A)NoneNone | 1.46A | 3kpbD-1g3mA:undetectable | 3kpbD-1g3mA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hk7 | HEAT SHOCK PROTEINHSP82 (Saccharomycescerevisiae) |
PF00183(HSP90) | 5 | ILE A 474THR A 525ASP A 523THR A 475VAL A 482 | None | 1.43A | 3kpbD-1hk7A:undetectable | 3kpbD-1hk7A:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i6a | HYDROGENPEROXIDE-INDUCIBLEGENES ACTIVATOR (Escherichiacoli) |
PF03466(LysR_substrate) | 5 | ILE A 98THR A 129ASP A 196THR A 100ILE A 268 | None | 1.38A | 3kpbD-1i6aA:undetectable | 3kpbD-1i6aA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ibj | CYSTATHIONINEBETA-LYASE (Arabidopsisthaliana) |
PF01053(Cys_Met_Meta_PP) | 5 | ILE A 239TRP A 222THR A 204VAL A 210ILE A 214 | None | 1.41A | 3kpbD-1ibjA:undetectable | 3kpbD-1ibjA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iiw | SLR1257 PROTEIN (Synechocystissp. PCC 6803) |
PF00497(SBP_bac_3) | 5 | ILE A 73VAL A 193ILE A 68ILE A 70SER A 31 | None | 1.30A | 3kpbD-1iiwA:undetectable | 3kpbD-1iiwA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | THR A 139ASP A 142LYS A 145ILE A 129SER A 36 | None | 1.34A | 3kpbD-1izeA:undetectable | 3kpbD-1izeA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k3r | CONSERVED PROTEINMT0001 (Methanothermobacterthermautotrophicus) |
PF02598(Methyltrn_RNA_3) | 5 | ILE A 57THR A 15VAL A 28ILE A 31ILE A 10 | None | 1.14A | 3kpbD-1k3rA:undetectable | 3kpbD-1k3rA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qjo | DIHYDROLIPOAMIDEACETYLTRANSFERASE (Escherichiacoli) |
PF00364(Biotin_lipoyl) | 5 | ILE A 10ASP A 9VAL A 37ILE A 35ILE A 71 | None | 1.31A | 3kpbD-1qjoA:undetectable | 3kpbD-1qjoA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2v | ACTIN-RELATEDPROTEIN 3 (Bos taurus) |
PF00022(Actin) | 5 | ILE A 168THR A 326THR A 175VAL A 177ILE A 178 | None | 1.34A | 3kpbD-1u2vA:undetectable | 3kpbD-1u2vA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usv | HEAT SHOCK PROTEINHSP82 (Saccharomycescerevisiae) |
PF00183(HSP90) | 5 | ILE A 474THR A 525ASP A 523THR A 475VAL A 482 | None | 1.30A | 3kpbD-1usvA:undetectable | 3kpbD-1usvA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vr0 | PROBABLE2-PHOSPHOSULFOLACTATE PHOSPHATASE (Clostridiumacetobutylicum) |
PF04029(2-ph_phosp) | 5 | ILE A 133THR A 21VAL A 166ILE A 163ILE A 142 | None | 1.30A | 3kpbD-1vr0A:undetectable | 3kpbD-1vr0A:21.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xkf | HYPOTHETICAL PROTEINRV2626C (Mycobacteriumtuberculosis) |
PF00571(CBS) | 5 | ILE A 113THR A 115ASP A 118VAL A 12ILE A 33 | None | 0.93A | 3kpbD-1xkfA:16.7 | 3kpbD-1xkfA:30.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 139THR A 141ASP A 144THR A 160ILE A 185 | None | 0.90A | 3kpbD-1zfjA:15.8 | 3kpbD-1zfjA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5v | CARBONIC ANHYDRASE(CARBONATEDEHYDRATASE)(CARBONICDEHYDRATASE) (Mycobacteriumtuberculosis) |
PF00484(Pro_CA) | 5 | THR A 160VAL A 101ILE A 99ILE A 87SER A 86 | None | 1.34A | 3kpbD-2a5vA:undetectable | 3kpbD-2a5vA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cbf | COBALT-PRECORRIN-4TRANSMETHYLASE (Bacillusmegaterium) |
PF00590(TP_methylase) | 5 | TRP A 247THR A 150VAL A 153ILE A 154ILE A 180 | None | 1.28A | 3kpbD-2cbfA:undetectable | 3kpbD-2cbfA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e8b | PROBABLEMOLYBDOPTERIN-GUANINE DINUCLEOTIDEBIOSYNTHESIS PROTEINA (Aquifexaeolicus) |
PF12804(NTP_transf_3) | 5 | THR A 136TRP A 161ILE A 149ILE A 85SER A 84 | None | 1.13A | 3kpbD-2e8bA:undetectable | 3kpbD-2e8bA:21.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ef7 | HYPOTHETICAL PROTEINST2348 (Sulfurisphaeratokodaii) |
PF00571(CBS) | 6 | ILE A 49THR A 51ASP A 54LYS A 57THR A 74ILE A 98 | None | 1.10A | 3kpbD-2ef7A:14.6 | 3kpbD-2ef7A:33.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gca | FOLYLPOLYGLUTAMATESYNTHASE (Lactobacilluscasei) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | THR A 422VAL A 419ILE A 312ILE A 304SER A 305 | None | 1.32A | 3kpbD-2gcaA:undetectable | 3kpbD-2gcaA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oox | HYPOTHETICAL PROTEINC1556.08C INCHROMOSOME I (Schizosaccharomycespombe) |
no annotation | 5 | ILE G 303ASP G 308THR G 191ILE G 216SER G 217 | AMP G 401 (-4.0A)AMP G 401 (-2.6A)AMP G 401 (-3.7A)AMP G 401 (-3.7A)AMP G 401 (-2.3A) | 0.59A | 3kpbD-2ooxG:11.2 | 3kpbD-2ooxG:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p8e | PPM1B BETA ISOFORMVARIANT 6 (Homo sapiens) |
PF00481(PP2C) | 5 | TRP A 274THR A 278ILE A 245ILE A 290SER A 27 | NoneNoneOCS A 242 ( 4.1A)NoneNone | 1.41A | 3kpbD-2p8eA:undetectable | 3kpbD-2p8eA:18.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 124THR A 15VAL A 18ILE A 19ILE A 39 | None | 0.68A | 3kpbD-2p9mA:17.5 | 3kpbD-2p9mA:37.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc3 | CBS DOMAIN (Nitrosomonaseuropaea) |
PF00571(CBS) | 6 | ILE A 72THR A 74ASP A 77LYS A 81THR A 99VAL A 102 | None BR A 171 (-4.0A)NoneNone BR A 177 ( 4.2A)None | 0.83A | 3kpbD-2rc3A:17.7 | 3kpbD-2rc3A:29.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2re7 | UNCHARACTERIZEDPROTEIN (Psychrobacterarcticus) |
PF16242(Pyrid_ox_like) | 5 | ILE A 68VAL A 122ILE A 48ILE A 83SER A 82 | None | 1.18A | 3kpbD-2re7A:undetectable | 3kpbD-2re7A:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 6 | ILE A 172ASP A 177THR A 228VAL A 231ILE A 232ILE A 252 | SAM A6075 (-3.9A)SAM A6075 (-2.8A)SAM A6075 (-3.5A)SAM A6075 (-3.8A)SAM A6075 (-3.9A)SAM A6075 (-3.6A) | 0.63A | 3kpbD-2yzqA:15.8 | 3kpbD-2yzqA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ab0 | BCLA PROTEIN (Bacillusanthracis) |
no annotation | 5 | ILE A 136THR A 180ILE A 118ILE A 128SER A 187 | None | 1.27A | 3kpbD-3ab0A:undetectable | 3kpbD-3ab0A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3af5 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1404 (Pyrococcushorikoshii) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | ILE A 189ASP A 334THR A 209ILE A 191ILE A 362 | None | 1.18A | 3kpbD-3af5A:undetectable | 3kpbD-3af5A:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3beu | TRYPSIN (Streptomycesgriseus) |
PF00089(Trypsin) | 5 | ILE A 212ASP A 102THR A 229ILE A 123ILE A 238 | None | 1.43A | 3kpbD-3beuA:undetectable | 3kpbD-3beuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clv | RAB5 PROTEIN,PUTATIVE (Plasmodiumfalciparum) |
PF00071(Ras)PF08477(Roc) | 5 | ILE A 97THR A 10VAL A 24ILE A 23ILE A 194 | None | 1.31A | 3kpbD-3clvA:undetectable | 3kpbD-3clvA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cyq | CHEMOTAXIS PROTEINMOTB (Helicobacterpylori) |
no annotation | 5 | ILE B 241THR B 233ASP B 237ILE B 148ILE B 157 | None | 1.47A | 3kpbD-3cyqB:undetectable | 3kpbD-3cyqB:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0g | LEUKEMIA INHIBITORYFACTOR RECEPTOR (Homo sapiens) |
PF00041(fn3) | 5 | THR A 261VAL A 209ILE A 210ILE A 253SER A 254 | NoneNoneNoneNoneFUC A 492 ( 3.8A) | 1.27A | 3kpbD-3e0gA:undetectable | 3kpbD-3e0gA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ego | PROBABLE2-DEHYDROPANTOATE2-REDUCTASE (Bacillussubtilis) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | ILE A 93THR A 91VAL A 71ILE A 6ILE A 62 | None | 1.13A | 3kpbD-3egoA:undetectable | 3kpbD-3egoA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | THR A 378THR A 349VAL A 360ILE A 364ILE A 375 | None | 1.42A | 3kpbD-3f2bA:undetectable | 3kpbD-3f2bA:8.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhm | UNCHARACTERIZEDPROTEIN ATU1752 (Agrobacteriumfabrum) |
PF00571(CBS) | 5 | ILE A 52THR A 54ASP A 57THR A 79VAL A 82 | AMP A 200 (-4.0A)AMP A 200 (-2.9A)AMP A 200 (-2.9A)AMP A 200 (-3.5A)AMP A 200 ( 4.3A) | 0.39A | 3kpbD-3fhmA:16.4 | 3kpbD-3fhmA:27.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fna | POSSIBLE ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00571(CBS) | 5 | ILE A 259THR A 261ASP A 264THR A 285ILE A 289 | AMP A 401 (-4.8A)AMP A 401 (-3.1A)AMP A 401 (-2.7A)AMP A 401 (-3.1A)None | 0.95A | 3kpbD-3fnaA:15.2 | 3kpbD-3fnaA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fna | POSSIBLE ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00571(CBS) | 7 | ILE A 259THR A 261ASP A 264THR A 285ILE A 289ILE A 309SER A 311 | AMP A 401 (-4.8A)AMP A 401 (-3.1A)AMP A 401 (-2.7A)AMP A 401 (-3.1A)NoneAMP A 401 (-4.4A)None | 1.35A | 3kpbD-3fnaA:15.2 | 3kpbD-3fnaA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gg2 | SUGAR DEHYDROGENASE,UDP-GLUCOSE/GDP-MANNOSE DEHYDROGENASEFAMILY (Porphyromonasgingivalis) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | ILE A 160THR A 196ILE A 158ILE A 184SER A 183 | None | 1.46A | 3kpbD-3gg2A:undetectable | 3kpbD-3gg2A:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ics | COENZYME A-DISULFIDEREDUCTASE (Bacillusanthracis) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 235THR A 180THR A 237VAL A 227ILE A 159 | None | 1.39A | 3kpbD-3icsA:undetectable | 3kpbD-3icsA:13.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 5 | ILE A 258THR A 260ASP A 263THR A 284ILE A 288 | CMK A 1 (-4.2A)CMK A 1 (-3.4A)CMK A 1 (-2.8A)CMK A 1 (-3.1A)CMK A 1 (-3.7A) | 0.95A | 3kpbD-3k2vA:15.4 | 3kpbD-3k2vA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 6 | ILE A 258THR A 260ASP A 263THR A 284ILE A 288ILE A 308 | CMK A 1 (-4.2A)CMK A 1 (-3.4A)CMK A 1 (-2.8A)CMK A 1 (-3.1A)CMK A 1 (-3.7A)CMK A 1 (-3.7A) | 0.83A | 3kpbD-3k2vA:15.4 | 3kpbD-3k2vA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 51THR A 53ASP A 56VAL A 94ILE A 95 | ADP A 283 ( 4.2A)ADP A 283 (-2.7A)ADP A 283 (-2.8A)ADP A 283 (-3.7A)ADP A 283 (-3.8A) | 0.31A | 3kpbD-3kh5A:12.9 | 3kpbD-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 193THR A 195ASP A 198LYS A 201VAL A 233ILE A 234 | AMP A 282 ( 4.3A)AMP A 282 (-3.1A)AMP A 282 (-3.1A)AMP A 282 ( 3.7A)AMP A 282 (-3.8A)AMP A 282 (-3.9A) | 0.91A | 3kpbD-3kh5A:12.9 | 3kpbD-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 193THR A 195ASP A 198VAL A 233ILE A 234ILE A 254 | AMP A 282 ( 4.3A)AMP A 282 (-3.1A)AMP A 282 (-3.1A)AMP A 282 (-3.8A)AMP A 282 (-3.9A)AMP A 282 (-4.1A) | 0.39A | 3kpbD-3kh5A:12.9 | 3kpbD-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 7 | ILE A 269THR A 271ASP A 274LYS A 277THR A 155VAL A 158ILE A 159 | ADP A 284 ( 4.3A)ADP A 284 (-3.4A)ADP A 284 (-2.8A)ADP A 284 (-3.5A)ADP A 284 (-3.2A)ADP A 284 (-3.9A)ADP A 284 (-4.2A) | 0.58A | 3kpbD-3kh5A:12.9 | 3kpbD-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3klj | NAD(FAD)-DEPENDENTDEHYDROGENASE,NIRB-FAMILY(N-TERMINAL DOMAIN) (Clostridiumacetobutylicum) |
PF07992(Pyr_redox_2) | 5 | ILE A 82THR A 233ASP A 232VAL A 89ILE A 104 | None | 1.47A | 3kpbD-3kljA:undetectable | 3kpbD-3kljA:18.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 10 | ILE A 434THR A 436TRP A 438ASP A 439LYS A 442THR A 456VAL A 459ILE A 460ILE A 480SER A 481 | SAM A1000 ( 4.2A)SAM A1000 (-3.4A)SAM A1000 (-3.1A)SAM A1000 (-2.6A)SAM A1000 ( 3.7A)SAM A1000 (-3.0A)SAM A1000 ( 3.9A)SAM A1000 (-3.8A)SAM A1000 (-4.0A)SAM A1000 (-3.2A) | 0.22A | 3kpbD-3kpbA:24.0 | 3kpbD-3kpbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 495THR A 497ASP A 500ILE A 399ILE A 419 | None | 0.66A | 3kpbD-3kpbA:24.0 | 3kpbD-3kpbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3na6 | SUCCINYLGLUTAMATEDESUCCINYLASE/ASPARTOACYLASE (Ruegeria sp.TM1040) |
PF04952(AstE_AspA) | 5 | ILE A 43THR A 41THR A 75VAL A 80ILE A 237 | None | 1.36A | 3kpbD-3na6A:undetectable | 3kpbD-3na6A:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odm | PHOSPHOENOLPYRUVATECARBOXYLASE (Clostridiumperfringens) |
PF14010(PEPcase_2) | 5 | ILE A 47VAL A 79ILE A 117ILE A 101SER A 97 | None | 1.43A | 3kpbD-3odmA:undetectable | 3kpbD-3odmA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oop | LIN2960 PROTEIN (Listeriainnocua) |
PF01047(MarR) | 5 | THR A 58VAL A 39ILE A 43ILE A 49SER A 50 | None | 1.21A | 3kpbD-3oopA:undetectable | 3kpbD-3oopA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pen | TRANSLATIONINITIATION FACTOR 2SUBUNIT GAMMA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 5 | ILE A 272THR A 274ILE A 316ILE A 238SER A 220 | None | 1.22A | 3kpbD-3penA:undetectable | 3kpbD-3penA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppo | GLYCINEBETAINE/CARNITINE/CHOLINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 5 | ILE A 55THR A 63VAL A 261ILE A 262ILE A 86 | None | 1.15A | 3kpbD-3ppoA:undetectable | 3kpbD-3ppoA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ILE A 65THR A 67VAL A 145ILE A 146ILE A 149 | None | 1.11A | 3kpbD-3ramA:undetectable | 3kpbD-3ramA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlz | MCCF (Escherichiacoli) |
PF02016(Peptidase_S66) | 5 | ILE A 107THR A 131VAL A 78ILE A 86ILE A 114 | None | 1.30A | 3kpbD-3tlzA:undetectable | 3kpbD-3tlzA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgs | NUCLEOSIDEDIPHOSPHATE KINASE (Halomonas sp.#593) |
PF00334(NDK) | 5 | ILE A 103ASP A 106VAL A 116ILE A 10SER A 25 | None | 1.40A | 3kpbD-3vgsA:undetectable | 3kpbD-3vgsA:26.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopus laevis) |
no annotation | 5 | ILE B 386ASP B 390VAL B 146ILE B 145ILE B 370 | None | 1.37A | 3kpbD-3w0lB:undetectable | 3kpbD-3w0lB:11.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 487d | PROTEIN (50S L9RIBOSOMAL PROTEIN) (Geobacillusstearothermophilus) |
PF01281(Ribosomal_L9_N)PF03948(Ribosomal_L9_C) | 5 | ILE K 121THR K 127VAL K 145ILE K 98SER K 95 | None | 1.33A | 3kpbD-487dK:undetectable | 3kpbD-487dK:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a8e | PROBABLE TYROSINERECOMBINASEXERC-LIKE (Pyrococcusabyssi) |
PF00589(Phage_integrase)PF02899(Phage_int_SAM_1) | 5 | ILE A 177VAL A 147ILE A 154ILE A 169SER A 170 | None | 1.32A | 3kpbD-4a8eA:undetectable | 3kpbD-4a8eA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ege | DIPEPTIDASE PEPE (Mycobacteriumulcerans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | ILE A 65THR A 53TRP A 90VAL A 85SER A 74 | None | 1.45A | 3kpbD-4egeA:undetectable | 3kpbD-4egeA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | ILE A 359THR A 361ASP A 364THR A 407ILE A 431 | None | 1.09A | 3kpbD-4esyA:14.9 | 3kpbD-4esyA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fry | PUTATIVESIGNAL-TRANSDUCTIONPROTEIN WITH CBSDOMAINS (Burkholderiaambifaria) |
PF00571(CBS) | 6 | ILE A 54THR A 56ASP A 59LYS A 63THR A 81VAL A 84 | AMP A 202 (-4.1A)AMP A 202 (-2.9A)AMP A 202 (-2.6A)AMP A 202 ( 4.1A)AMP A 202 (-3.6A)AMP A 202 (-3.8A) | 0.69A | 3kpbD-4fryA:16.2 | 3kpbD-4fryA:29.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0n | NECROTIC ENTERITISTOXIN B (Clostridiumperfringens) |
PF07968(Leukocidin) | 5 | ILE A 142THR A 189ILE A 137ILE A 180SER A 181 | None | 1.30A | 3kpbD-4i0nA:undetectable | 3kpbD-4i0nA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4k | UNCHARACTERIZEDPROTEIN SGCJ (Streptomycesglobisporus) |
PF14534(DUF4440) | 5 | ILE A 100THR A 75VAL A 77ILE A 78SER A 109 | NoneNonePG4 A 202 (-4.7A)NoneNone | 1.43A | 3kpbD-4i4kA:undetectable | 3kpbD-4i4kA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3b | M1 FAMILYAMINOPEPTIDASE (Plasmodiumfalciparum) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 5 | LYS A1044THR A 576VAL A 579ILE A 563SER A 649 | None | 1.27A | 3kpbD-4j3bA:undetectable | 3kpbD-4j3bA:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j4b | PYLD (Methanosarcinabarkeri) |
no annotation | 5 | ILE A 132THR A 27VAL A 23ILE A 31SER A 253 | None | 1.39A | 3kpbD-4j4bA:undetectable | 3kpbD-4j4bA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j6c | CYTOCHROME P450MONOOXYGENASE (Nocardiafarcinica) |
PF00067(p450) | 5 | ILE A 220ASP A 214THR A 216VAL A 234ILE A 235 | None | 1.45A | 3kpbD-4j6cA:undetectable | 3kpbD-4j6cA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyp | HYDROLASE,ALPHA/BETA FOLDFAMILY PROTEIN (Arabidopsisthaliana) |
PF12697(Abhydrolase_6) | 5 | ILE A 241VAL A 259ILE A 260ILE A 118SER A 119 | None | 1.42A | 3kpbD-4jypA:undetectable | 3kpbD-4jypA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgn | CELLULOSE-BINDING,FAMILY II (Acidothermuscellulolyticus) |
no annotation | 5 | ILE A 421ASP A 409THR A 407ILE A 328ILE A 341 | None | 1.34A | 3kpbD-4lgnA:undetectable | 3kpbD-4lgnA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mct | ANTIDOTE PROTEIN (Proteusvulgaris) |
PF01381(HTH_3) | 5 | THR A 37VAL A 33ILE A 31ILE A 56SER A 53 | None | 1.46A | 3kpbD-4mctA:undetectable | 3kpbD-4mctA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mp3 | PUTATIVE ORNITHINECYCLODEAMINASE (Staphylococcusaureus) |
PF02423(OCD_Mu_crystall) | 5 | ILE A 150THR A 123ILE A 144ILE A 211SER A 233 | GOL A 402 (-3.9A)SO4 A 401 ( 4.4A)NoneNoneNone | 1.34A | 3kpbD-4mp3A:undetectable | 3kpbD-4mp3A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4opu | CONSERVED ARCHAEALPROTEIN (Sulfolobusacidocaldarius) |
PF01266(DAO) | 5 | ILE A 11THR A 157VAL A 153ILE A 283SER A 165 | NoneFDA A 501 (-3.8A)NoneNoneNone | 1.33A | 3kpbD-4opuA:undetectable | 3kpbD-4opuA:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pmj | PUTATIVEOXIDOREDUCTASE (Sinorhizobiummeliloti) |
PF00248(Aldo_ket_red) | 5 | ILE A 51THR A 53VAL A 66ILE A 65SER A 39 | None | 1.40A | 3kpbD-4pmjA:undetectable | 3kpbD-4pmjA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r04 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80)PF12918(TcdB_N)PF12919(TcdA_TcdB)PF12920(TcdA_TcdB_pore) | 5 | ASP A1350VAL A1085ILE A1084ILE A1346SER A1325 | None | 1.27A | 3kpbD-4r04A:undetectable | 3kpbD-4r04A:5.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r6i | ANTHRAX TOXINEXPRESSIONTRANS-ACTINGPOSITIVE REGULATOR (Bacillusanthracis) |
PF00874(PRD)PF05043(Mga)PF08279(HTH_11) | 5 | ILE A 408VAL A 396ILE A 444ILE A 459SER A 460 | None | 1.44A | 3kpbD-4r6iA:undetectable | 3kpbD-4r6iA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wa0 | POSSIBLE ADHESIN (Caldicellulosiruptorkronotskyensis) |
no annotation | 5 | ILE A 428ASP A 424THR A 427ILE A 438SER A 441 | None | 1.34A | 3kpbD-4wa0A:undetectable | 3kpbD-4wa0A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 5 | THR A 81TRP A 860ASP A 829THR A 827SER A 172 | None | 1.46A | 3kpbD-4zgvA:undetectable | 3kpbD-4zgvA:8.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zps | MCG133388, ISOFORMCRA_M (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 5 | ILE A 2VAL A 90ILE A 79ILE A 19SER A 20 | None | 1.43A | 3kpbD-4zpsA:undetectable | 3kpbD-4zpsA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | PROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT BETAPROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT DELTA (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF01008(IF-2B)PF01008(IF-2B) | 5 | ILE C 230THR C 257VAL C 271ILE G 122SER G 121 | None | 1.31A | 3kpbD-5b04C:undetectable | 3kpbD-5b04C:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxp | LACTO-N-BIOSIDASE (Bifidobacteriumbifidum) |
PF00728(Glyco_hydro_20)PF02838(Glyco_hydro_20b)PF14200(RicinB_lectin_2) | 5 | ILE A 356ASP A 360LYS A 364ILE A 377ILE A 391 | None | 1.35A | 3kpbD-5bxpA:undetectable | 3kpbD-5bxpA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp)PF01740(STAS) | 5 | ILE A 249THR A 245VAL A 292ILE A 74SER A 75 | None | 1.16A | 3kpbD-5da0A:undetectable | 3kpbD-5da0A:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5x | SITE-2 PROTEASE (Archaeoglobusfulgidus) |
PF00571(CBS) | 5 | ILE A 277THR A 279ASP A 282VAL A 300ILE A 321 | ATP A1355 (-4.1A)ATP A1355 (-2.4A)ATP A1355 (-1.9A)ATP A1355 (-3.8A)ATP A1355 (-4.5A) | 0.62A | 3kpbD-5g5xA:17.3 | 3kpbD-5g5xA:29.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gtk | BETAINE-ALDEHYDEDEHYDROGENASE (Bacillus cereus) |
PF00171(Aldedh) | 5 | ILE A 252THR A 248VAL A 232ILE A 231ILE A 164 | NoneNAD A 501 (-3.2A)NoneNoneNAD A 501 (-4.3A) | 1.31A | 3kpbD-5gtkA:undetectable | 3kpbD-5gtkA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7j | ELONGATION FACTOR 2 (Pyrococcushorikoshii) |
no annotation | 5 | THR A 695VAL A 632ILE A 634ILE A 683SER A 682 | None | 1.26A | 3kpbD-5h7jA:undetectable | 3kpbD-5h7jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hd2 | PARASPORAL CRYSTALPROTEIN (Bacillusthuringiensis) |
PF03318(ETX_MTX2) | 5 | THR A 41VAL A 10ILE A 14ILE A 34SER A 35 | None | 1.47A | 3kpbD-5hd2A:undetectable | 3kpbD-5hd2A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iof | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp) | 5 | ILE A 249THR A 245VAL A 292ILE A 74SER A 75 | None | 1.16A | 3kpbD-5iofA:undetectable | 3kpbD-5iofA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxr | CHROMATIN-REMODELINGCOMPLEX ATPASE-LIKEPROTEIN (Thermothelomycesthermophila) |
PF00176(SNF2_N)PF00271(Helicase_C) | 5 | ILE A 296THR A 291VAL A 329ILE A 330ILE A 311 | None | 1.46A | 3kpbD-5jxrA:undetectable | 3kpbD-5jxrA:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIII,IG GAMMA-1CHAIN C REGION (Homo sapiens) |
PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2) | 5 | ILE B1771TRP B1835VAL B1773ILE B1790SER B1791 | None | 1.37A | 3kpbD-5k8dB:undetectable | 3kpbD-5k8dB:8.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2e | GLUTAMATE RECEPTORIONOTROPIC,DELTA-2,GLUTAMATERECEPTOR IONOTROPIC,DELTA-2 (Rattusnorvegicus) |
PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | ILE A 284THR A 282VAL A 155ILE A 156ILE A 231 | None | 1.28A | 3kpbD-5l2eA:undetectable | 3kpbD-5l2eA:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lad | PUTATIVE GTP-BINDINGPROTEIN (Thermotogamaritima) |
PF01926(MMR_HSR1) | 5 | ILE A 168THR A 164VAL A 119ILE A 93ILE A 12 | None | 1.33A | 3kpbD-5ladA:undetectable | 3kpbD-5ladA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5muw | PACKAGING ENZYME P4 (Pseudomonasvirus phi6) |
PF11602(NTPase_P4) | 5 | ILE A 172THR A 73ILE A 146ILE A 164SER A 165 | None | 1.26A | 3kpbD-5muwA:undetectable | 3kpbD-5muwA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvd | CBS-CP12 (Microcystisaeruginosa) |
no annotation | 5 | ILE A 52THR A 54ASP A 57LYS A 61ILE A 103 | None | 0.83A | 3kpbD-5nvdA:14.6 | 3kpbD-5nvdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvd | CBS-CP12 (Microcystisaeruginosa) |
no annotation | 5 | ILE A 117ASP A 122LYS A 126THR A 12VAL A 15 | None | 0.90A | 3kpbD-5nvdA:14.6 | 3kpbD-5nvdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc3 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Eremotheciumgossypii) |
PF00478(IMPDH)PF00571(CBS) | 6 | ILE A 163THR A 165ASP A 168THR A 184VAL A 187ILE A 188 | ATP A 601 ( 4.6A)ATP A 601 (-2.7A)ATP A 601 (-2.3A)ATP A 601 (-2.8A)ATP A 601 (-4.0A)ATP A 601 (-4.2A) | 0.52A | 3kpbD-5tc3A:14.8 | 3kpbD-5tc3A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1s | SEPARINSECURIN (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF03568(Peptidase_C50)PF04856(Securin) | 5 | THR A1567THR A1231VAL A1236ILE A1240ILE B 259 | None | 1.31A | 3kpbD-5u1sA:undetectable | 3kpbD-5u1sA:6.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vni | PROTEIN TRANSPORTPROTEIN SEC23A (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | TRP A 252THR A 137VAL A 135ILE A 167SER A 186 | None | 1.17A | 3kpbD-5vniA:undetectable | 3kpbD-5vniA:8.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5woy | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Caldanaerobactersubterraneus) |
no annotation | 5 | ILE A 137THR A 50VAL A 104ILE A 86SER A 81 | None | 1.36A | 3kpbD-5woyA:undetectable | 3kpbD-5woyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yh5 | NICKEL ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Staphylococcusaureus) |
no annotation | 5 | ILE A 465THR A 429ILE A 416ILE A 442SER A 441 | None | 1.46A | 3kpbD-5yh5A:undetectable | 3kpbD-5yh5A:undetectable |