SIMILAR PATTERNS OF AMINO ACIDS FOR 3KPB_C_SAMC1000_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k3r | CONSERVED PROTEINMT0001 (Methanothermobacterthermautotrophicus) |
PF02598(Methyltrn_RNA_3) | 5 | ILE A 57THR A 15VAL A 28ILE A 31ILE A 10 | None | 1.14A | 3kpbC-1k3rA:0.0 | 3kpbC-1k3rA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mab | PROTEIN (F1-ATPASEBETA CHAIN) (Rattusnorvegicus) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | ILE B 108THR B 90THR B 110ILE B 84PRO B 101 | None | 1.18A | 3kpbC-1mabB:undetectable | 3kpbC-1mabB:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfj | 3-DEHYDROQUINATEDEHYDRATASE (Staphylococcusaureus) |
PF01487(DHquinase_I) | 5 | HIS A 114ILE A 118VAL A 128ILE A 101ILE A 89 | None | 1.24A | 3kpbC-1sfjA:undetectable | 3kpbC-1sfjA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ugh | PROTEIN (URACIL-DNAGLYCOSYLASEINHIBITOR) (Bacillus phagePBS2) |
no annotation | 5 | ILE I 41THR I 59VAL I 29ILE I 33PRO I 37 | None | 1.10A | 3kpbC-1ughI:undetectable | 3kpbC-1ughI:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmr | ISOPULLULANASE (Aspergillusniger) |
PF03718(Glyco_hydro_49)PF17433(Glyco_hydro_49N) | 5 | ASP A 159VAL A 141ILE A 143ILE A 125SER A 155 | None | 1.28A | 3kpbC-1wmrA:undetectable | 3kpbC-1wmrA:12.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xkf | HYPOTHETICAL PROTEINRV2626C (Mycobacteriumtuberculosis) |
PF00571(CBS) | 6 | ILE A 113THR A 115ASP A 118VAL A 12ILE A 33PRO A 37 | None | 0.95A | 3kpbC-1xkfA:16.7 | 3kpbC-1xkfA:30.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yv7 | P-30 PROTEIN (Rana pipiens) |
PF00074(RnaseA) | 5 | ILE A 47THR A 59VAL A 88ILE A 37PRO A 95 | None | 1.18A | 3kpbC-1yv7A:undetectable | 3kpbC-1yv7A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 139THR A 141ASP A 144ILE A 185PRO A 189 | None | 1.24A | 3kpbC-1zfjA:15.9 | 3kpbC-1zfjA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 6 | ILE A 139THR A 141ASP A 144THR A 160ILE A 185PRO A 189 | None | 0.98A | 3kpbC-1zfjA:15.9 | 3kpbC-1zfjA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | THR A 202ASP A 205ILE A 122SER A 123PRO A 126 | None | 0.81A | 3kpbC-1zfjA:15.9 | 3kpbC-1zfjA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cbn | RIBONUCLEASE Z (Escherichiacoli) |
PF12706(Lactamase_B_2) | 5 | HIS A 69THR A 20THR A 43ILE A 62SER A 63 | ZN A 402 (-3.3A)NoneNoneNoneNone | 1.23A | 3kpbC-2cbnA:undetectable | 3kpbC-2cbnA:18.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ef7 | HYPOTHETICAL PROTEINST2348 (Sulfurisphaeratokodaii) |
PF00571(CBS) | 5 | HIS A 100ILE A 49THR A 74ILE A 98PRO A 102 | None | 1.10A | 3kpbC-2ef7A:14.6 | 3kpbC-2ef7A:33.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ef7 | HYPOTHETICAL PROTEINST2348 (Sulfurisphaeratokodaii) |
PF00571(CBS) | 5 | ILE A 49ASP A 54THR A 74ILE A 98PRO A 102 | None | 1.09A | 3kpbC-2ef7A:14.6 | 3kpbC-2ef7A:33.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ef7 | HYPOTHETICAL PROTEINST2348 (Sulfurisphaeratokodaii) |
PF00571(CBS) | 6 | ILE A 49THR A 51ASP A 54LYS A 57THR A 74ILE A 98 | None | 1.13A | 3kpbC-2ef7A:14.6 | 3kpbC-2ef7A:33.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g7i | COMPLEMENT FACTOR H (Homo sapiens) |
PF00084(Sushi) | 5 | ILE A1120THR A1121VAL A1134ILE A1150PRO A1112 | None | 1.18A | 3kpbC-2g7iA:undetectable | 3kpbC-2g7iA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glj | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Clostridiumacetobutylicum) |
PF02127(Peptidase_M18) | 5 | THR A 157VAL A 152ILE A 151ILE A 231SER A 232 | None | 1.19A | 3kpbC-2gljA:undetectable | 3kpbC-2gljA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j9l | CHLORIDE CHANNELPROTEIN 5 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 722THR A 724ASP A 727LYS A 730PRO A 621 | ATP A1752 (-4.1A)ATP A1752 (-2.7A)ATP A1752 (-2.7A)NoneNone | 1.06A | 3kpbC-2j9lA:12.3 | 3kpbC-2j9lA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j9l | CHLORIDE CHANNELPROTEIN 5 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 722THR A 724ASP A 727SER A 618PRO A 621 | ATP A1752 (-4.1A)ATP A1752 (-2.7A)ATP A1752 (-2.7A)ATP A1752 (-3.3A)None | 0.57A | 3kpbC-2j9lA:12.3 | 3kpbC-2j9lA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o16 | ACETOIN UTILIZATIONPROTEIN ACUB,PUTATIVE (Vibrio cholerae) |
PF00571(CBS) | 5 | HIS A 54ILE A 67ASP A 72ILE A 125PRO A 129 | PO4 A 1 (-3.8A)NonePO4 A 7 (-2.9A)NoneNone | 1.26A | 3kpbC-2o16A:17.3 | 3kpbC-2o16A:26.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o16 | ACETOIN UTILIZATIONPROTEIN ACUB,PUTATIVE (Vibrio cholerae) |
PF00571(CBS) | 7 | HIS A 54ILE A 139THR A 141ASP A 144THR A 28ILE A 52PRO A 56 | PO4 A 1 (-3.8A)NonePO4 A 1 (-3.0A)NoneNonePO4 A 1 (-4.4A)None | 0.90A | 3kpbC-2o16A:17.3 | 3kpbC-2o16A:26.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oox | HYPOTHETICAL PROTEINC1556.08C INCHROMOSOME I (Schizosaccharomycespombe) |
no annotation | 6 | ILE G 303ASP G 308THR G 191ILE G 216SER G 217PRO G 220 | AMP G 401 (-4.0A)AMP G 401 (-2.6A)AMP G 401 (-3.7A)AMP G 401 (-3.7A)AMP G 401 (-2.3A)AMP G 401 (-4.7A) | 0.76A | 3kpbC-2ooxG:11.3 | 3kpbC-2ooxG:20.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 54THR A 56VAL A 83ILE A 84PRO A 113 | None | 0.70A | 3kpbC-2p9mA:17.6 | 3kpbC-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 54THR A 56VAL A 83ILE A 109PRO A 113 | None | 0.57A | 3kpbC-2p9mA:17.6 | 3kpbC-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 124ASP A 129THR A 15ILE A 39PRO A 43 | None | 0.98A | 3kpbC-2p9mA:17.6 | 3kpbC-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 124ASP A 129THR A 15VAL A 18PRO A 43 | None | 0.49A | 3kpbC-2p9mA:17.6 | 3kpbC-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 124THR A 15VAL A 18ILE A 19ILE A 39PRO A 43 | None | 0.66A | 3kpbC-2p9mA:17.6 | 3kpbC-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | THR A 56THR A 80VAL A 83ILE A 84PRO A 113 | None | 0.84A | 3kpbC-2p9mA:17.6 | 3kpbC-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | THR A 56THR A 80VAL A 83ILE A 109PRO A 113 | None | 0.75A | 3kpbC-2p9mA:17.6 | 3kpbC-2p9mA:37.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1d | 2-KETO-3-DEOXY-D-ARABINONATE DEHYDRATASE (Sulfolobussolfataricus) |
PF01557(FAA_hydrolase) | 5 | ILE X 251THR X 160THR X 253VAL X 76PRO X 73 | None | 1.20A | 3kpbC-2q1dX:undetectable | 3kpbC-2q1dX:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qby | CELL DIVISIONCONTROL PROTEIN 6HOMOLOG 1 (Sulfolobussolfataricus) |
PF09079(Cdc6_C)PF13401(AAA_22) | 5 | THR A 325VAL A 343ILE A 347ILE A 372SER A 317 | None | 1.27A | 3kpbC-2qbyA:undetectable | 3kpbC-2qbyA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlv | NUCLEAR PROTEIN SNF4 (Saccharomycescerevisiae) |
PF00571(CBS) | 5 | THR C 309ASP C 312THR C 195SER C 221PRO C 224 | None | 0.87A | 3kpbC-2qlvC:9.3 | 3kpbC-2qlvC:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc3 | CBS DOMAIN (Nitrosomonaseuropaea) |
PF00571(CBS) | 8 | HIS A 125ILE A 72THR A 74ASP A 77LYS A 81THR A 99VAL A 102PRO A 127 | NAD A1000 (-3.9A)None BR A 171 (-4.0A)NoneNone BR A 177 ( 4.2A)NoneNone | 0.85A | 3kpbC-2rc3A:17.9 | 3kpbC-2rc3A:29.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ygt | DELTA TOXIN (Clostridiumperfringens) |
PF07968(Leukocidin) | 5 | ILE A 115THR A 117VAL A 120SER A 135PRO A 111 | None | 1.18A | 3kpbC-2ygtA:undetectable | 3kpbC-2ygtA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzi | HYPOTHETICAL PROTEINPH0107 (Pyrococcushorikoshii) |
PF00571(CBS) | 5 | HIS A 106ILE A 118THR A 120ASP A 123THR A 15 | None | 0.62A | 3kpbC-2yziA:15.9 | 3kpbC-2yziA:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzi | HYPOTHETICAL PROTEINPH0107 (Pyrococcushorikoshii) |
PF00571(CBS) | 5 | HIS A 106THR A 56ASP A 59THR A 80ILE A 84 | None | 1.23A | 3kpbC-2yziA:15.9 | 3kpbC-2yziA:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzi | HYPOTHETICAL PROTEINPH0107 (Pyrococcushorikoshii) |
PF00571(CBS) | 5 | HIS A 106THR A 56THR A 80ILE A 84ILE A 104 | None | 0.82A | 3kpbC-2yziA:15.9 | 3kpbC-2yziA:27.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 5 | ILE A 106THR A 108ASP A 111THR A 8PRO A 36 | None | 0.70A | 3kpbC-2yzqA:16.0 | 3kpbC-2yzqA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 7 | ILE A 172ASP A 177THR A 228VAL A 231ILE A 232ILE A 252PRO A 256 | SAM A6075 (-3.9A)SAM A6075 (-2.8A)SAM A6075 (-3.5A)SAM A6075 (-3.8A)SAM A6075 (-3.9A)SAM A6075 (-3.6A)SAM A6075 (-4.6A) | 0.65A | 3kpbC-2yzqA:16.0 | 3kpbC-2yzqA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ab0 | BCLA PROTEIN (Bacillusanthracis) |
no annotation | 5 | ILE A 136THR A 180ILE A 118ILE A 128SER A 187 | None | 1.28A | 3kpbC-3ab0A:undetectable | 3kpbC-3ab0A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3af5 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1404 (Pyrococcushorikoshii) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | ILE A 189ASP A 334THR A 209ILE A 191ILE A 362 | None | 1.18A | 3kpbC-3af5A:undetectable | 3kpbC-3af5A:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddj | CBSDOMAIN-CONTAININGPROTEIN (Sulfolobussolfataricus) |
PF00571(CBS) | 5 | ILE A 254THR A 256ASP A 259VAL A 147PRO A 172 | AMP A 278 ( 4.5A)AMP A 278 (-3.1A)AMP A 278 (-2.7A)AMP A 278 ( 3.6A)AMP A 278 (-4.7A) | 0.48A | 3kpbC-3ddjA:12.1 | 3kpbC-3ddjA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhm | UNCHARACTERIZEDPROTEIN ATU1752 (Agrobacteriumfabrum) |
PF00571(CBS) | 7 | HIS A 105ILE A 52THR A 54ASP A 57THR A 79VAL A 82PRO A 107 | NAI A 211 ( 4.0A)AMP A 200 (-4.0A)AMP A 200 (-2.9A)AMP A 200 (-2.9A)AMP A 200 (-3.5A)AMP A 200 ( 4.3A)AMP A 200 (-4.7A) | 0.80A | 3kpbC-3fhmA:16.7 | 3kpbC-3fhmA:27.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhm | UNCHARACTERIZEDPROTEIN ATU1752 (Agrobacteriumfabrum) |
PF00571(CBS) | 5 | HIS A 105ILE A 117ASP A 122VAL A 16ILE A 37 | NAI A 211 ( 4.0A)NAI A 211 (-4.2A)NAI A 211 (-2.8A)NAI A 211 (-3.7A)NAI A 211 (-3.8A) | 0.88A | 3kpbC-3fhmA:16.7 | 3kpbC-3fhmA:27.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fna | POSSIBLE ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00571(CBS) | 5 | ILE A 259THR A 261ASP A 264THR A 285ILE A 289 | AMP A 401 (-4.8A)AMP A 401 (-3.1A)AMP A 401 (-2.7A)AMP A 401 (-3.1A)None | 0.95A | 3kpbC-3fnaA:15.6 | 3kpbC-3fnaA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fna | POSSIBLE ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00571(CBS) | 7 | ILE A 259THR A 261ASP A 264THR A 285ILE A 289ILE A 309SER A 311 | AMP A 401 (-4.8A)AMP A 401 (-3.1A)AMP A 401 (-2.7A)AMP A 401 (-3.1A)NoneAMP A 401 (-4.4A)None | 1.36A | 3kpbC-3fnaA:15.6 | 3kpbC-3fnaA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ILE A 139VAL A 146ILE A 149ILE A 127PRO A 173 | None | 1.20A | 3kpbC-3g1uA:undetectable | 3kpbC-3g1uA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 5 | ILE A 258THR A 260ASP A 263THR A 284ILE A 288 | CMK A 1 (-4.2A)CMK A 1 (-3.4A)CMK A 1 (-2.8A)CMK A 1 (-3.1A)CMK A 1 (-3.7A) | 0.96A | 3kpbC-3k2vA:15.6 | 3kpbC-3k2vA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 6 | ILE A 258THR A 260ASP A 263THR A 284ILE A 288ILE A 308 | CMK A 1 (-4.2A)CMK A 1 (-3.4A)CMK A 1 (-2.8A)CMK A 1 (-3.1A)CMK A 1 (-3.7A)CMK A 1 (-3.7A) | 0.79A | 3kpbC-3k2vA:15.6 | 3kpbC-3k2vA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 51LYS A 66VAL A 94ILE A 95PRO A 119 | ADP A 283 ( 4.2A)ADP A 283 ( 4.4A)ADP A 283 (-3.7A)ADP A 283 (-3.8A)None | 1.11A | 3kpbC-3kh5A:12.9 | 3kpbC-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 51THR A 53ASP A 56VAL A 94ILE A 95PRO A 119 | ADP A 283 ( 4.2A)ADP A 283 (-2.7A)ADP A 283 (-2.8A)ADP A 283 (-3.7A)ADP A 283 (-3.8A)None | 0.35A | 3kpbC-3kh5A:12.9 | 3kpbC-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 8 | ILE A 193THR A 195ASP A 198LYS A 201VAL A 233ILE A 234ILE A 254PRO A 258 | AMP A 282 ( 4.3A)AMP A 282 (-3.1A)AMP A 282 (-3.1A)AMP A 282 ( 3.7A)AMP A 282 (-3.8A)AMP A 282 (-3.9A)AMP A 282 (-4.1A)None | 0.95A | 3kpbC-3kh5A:12.9 | 3kpbC-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 8 | ILE A 269THR A 271ASP A 274LYS A 277THR A 155VAL A 158ILE A 159PRO A 183 | ADP A 284 ( 4.3A)ADP A 284 (-3.4A)ADP A 284 (-2.8A)ADP A 284 (-3.5A)ADP A 284 (-3.2A)ADP A 284 (-3.9A)ADP A 284 (-4.2A)None | 0.55A | 3kpbC-3kh5A:12.9 | 3kpbC-3kh5A:21.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 12 | HIS A 421ILE A 434THR A 436TRP A 438ASP A 439LYS A 442THR A 456VAL A 459ILE A 460ILE A 480SER A 481PRO A 484 | NoneSAM A1000 ( 4.2A)SAM A1000 (-3.4A)SAM A1000 (-3.1A)SAM A1000 (-2.6A)SAM A1000 ( 3.7A)SAM A1000 (-3.0A)SAM A1000 ( 3.9A)SAM A1000 (-3.8A)SAM A1000 (-4.0A)SAM A1000 (-3.2A)None | 0.22A | 3kpbC-3kpbA:24.6 | 3kpbC-3kpbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 7 | HIS A 421ILE A 495THR A 497ASP A 500ILE A 399ILE A 419PRO A 423 | None | 0.81A | 3kpbC-3kpbA:24.6 | 3kpbC-3kpbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocm | PUTATIVE MEMBRANEPROTEIN (Bordetellaparapertussis) |
PF00571(CBS) | 5 | THR A 443ASP A 446THR A 339VAL A 344PRO A 369 | ADP A 470 (-3.0A)ADP A 470 (-2.8A)ADP A 470 (-3.6A)ADP A 470 ( 4.0A)None | 0.58A | 3kpbC-3ocmA:10.1 | 3kpbC-3ocmA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oop | LIN2960 PROTEIN (Listeriainnocua) |
PF01047(MarR) | 5 | THR A 58VAL A 39ILE A 43ILE A 49SER A 50 | None | 1.20A | 3kpbC-3oopA:undetectable | 3kpbC-3oopA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pen | TRANSLATIONINITIATION FACTOR 2SUBUNIT GAMMA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 5 | ILE A 272THR A 274ILE A 316ILE A 238SER A 220 | None | 1.26A | 3kpbC-3penA:undetectable | 3kpbC-3penA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppo | GLYCINEBETAINE/CARNITINE/CHOLINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 5 | ILE A 55THR A 63VAL A 261ILE A 262ILE A 86 | None | 1.16A | 3kpbC-3ppoA:undetectable | 3kpbC-3ppoA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ram | HMRA PROTEIN (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ILE A 65THR A 67VAL A 145ILE A 146ILE A 149 | None | 1.14A | 3kpbC-3ramA:undetectable | 3kpbC-3ramA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tgw | V-TYPE ATP SYNTHASEBETA CHAIN (Methanosarcinamazei) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | ILE A 131ASP A 135THR A 129ILE A 326PRO A 339 | None | 1.18A | 3kpbC-3tgwA:undetectable | 3kpbC-3tgwA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 137THR A 139ASP A 142ILE A 183PRO A 187 | None | 0.86A | 3kpbC-3tsdA:14.3 | 3kpbC-3tsdA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 137THR A 139ASP A 142ILE A 183PRO A 187 | None | 1.15A | 3kpbC-3tsdA:14.3 | 3kpbC-3tsdA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr5 | V-TYPE SODIUM ATPASESUBUNIT B (Enterococcushirae) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | ILE D 132ASP D 136THR D 130ILE D 327PRO D 340 | None | 1.19A | 3kpbC-3vr5D:undetectable | 3kpbC-3vr5D:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zbv | ANGIOGENIN-2 (Mus musculus) |
PF00074(RnaseA) | 5 | HIS A 13ILE A 46THR A 44ILE A 56ILE A 104 | None | 1.11A | 3kpbC-3zbvA:undetectable | 3kpbC-3zbvA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zbw | ANGIOGENIN-3 (Mus musculus) |
PF00074(RnaseA) | 5 | HIS A 13ILE A 46THR A 44ILE A 56ILE A 104 | SO4 A1123 (-4.1A)NoneNoneNoneNone | 1.17A | 3kpbC-3zbwA:undetectable | 3kpbC-3zbwA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zjc | GTPASE IMAP FAMILYMEMBER 7 (Homo sapiens) |
PF04548(AIG1) | 5 | HIS A 126ILE A 95VAL A 12ILE A 11PRO A 92 | None | 1.10A | 3kpbC-3zjcA:undetectable | 3kpbC-3zjcA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dje | CORRINOID/IRON-SULFUR PROTEIN SMALLSUBUNIT (Moorellathermoacetica) |
PF03599(CdhD) | 5 | ILE D 213VAL D 249ILE D 250ILE D 184PRO D 215 | None | 0.95A | 3kpbC-4djeD:undetectable | 3kpbC-4djeD:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | ILE A 359THR A 361ASP A 364THR A 407ILE A 431 | None | 1.08A | 3kpbC-4esyA:15.2 | 3kpbC-4esyA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | ILE A 359THR A 361ASP A 364THR A 407PRO A 435 | None | 0.87A | 3kpbC-4esyA:15.2 | 3kpbC-4esyA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | THR A 447ASP A 450LYS A 453ILE A 344PRO A 348 | CL A 502 (-4.1A)NoneNoneNoneNone | 1.09A | 3kpbC-4esyA:15.2 | 3kpbC-4esyA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | THR A 447ASP A 450LYS A 453ILE A 344PRO A 348 | CL A 502 (-4.1A)NoneNoneNoneNone | 1.25A | 3kpbC-4esyA:15.2 | 3kpbC-4esyA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fry | PUTATIVESIGNAL-TRANSDUCTIONPROTEIN WITH CBSDOMAINS (Burkholderiaambifaria) |
PF00571(CBS) | 8 | HIS A 107ILE A 54THR A 56ASP A 59LYS A 63THR A 81VAL A 84PRO A 109 | AMP A 202 ( 3.7A)AMP A 202 (-4.1A)AMP A 202 (-2.9A)AMP A 202 (-2.6A)AMP A 202 ( 4.1A)AMP A 202 (-3.6A)AMP A 202 (-3.8A)AMP A 202 (-4.7A) | 0.77A | 3kpbC-4fryA:16.4 | 3kpbC-4fryA:29.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqw | CBSDOMAIN-CONTAININGPROTEIN CBSX1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00571(CBS) | 5 | ILE A 215THR A 217THR A 82ILE A 108PRO A 112 | None | 0.94A | 3kpbC-4gqwA:16.7 | 3kpbC-4gqwA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0n | NECROTIC ENTERITISTOXIN B (Clostridiumperfringens) |
PF07968(Leukocidin) | 5 | ILE A 142THR A 189ILE A 137ILE A 180SER A 181 | None | 1.28A | 3kpbC-4i0nA:undetectable | 3kpbC-4i0nA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iys | METAL TRANSPORTERCNNM2 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 566THR A 568ASP A 571THR A 451PRO A 482 | None | 1.00A | 3kpbC-4iysA:10.4 | 3kpbC-4iysA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3b | M1 FAMILYAMINOPEPTIDASE (Plasmodiumfalciparum) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 5 | LYS A1044THR A 576VAL A 579ILE A 563SER A 649 | None | 1.23A | 3kpbC-4j3bA:undetectable | 3kpbC-4j3bA:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nph | PROBABLE SECRETIONSYSTEM APPARATUS ATPSYNTHASE SSAN (Salmonellaenterica) |
PF00006(ATP-synt_ab) | 5 | ILE A 143ASP A 147THR A 141ILE A 329PRO A 342 | None | 1.13A | 3kpbC-4nphA:undetectable | 3kpbC-4nphA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8m | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Actinobacillussuccinogenes) |
PF03480(DctP) | 5 | HIS A 232THR A 230VAL A 302ILE A 181PRO A 108 | None | 1.19A | 3kpbC-4o8mA:undetectable | 3kpbC-4o8mA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9k | ARABINOSE5-PHOSPHATEISOMERASE (Methylococcuscapsulatus) |
PF00571(CBS) | 5 | THR A 256ASP A 259THR A 280ILE A 304PRO A 308 | CMK A 401 (-3.4A)CMK A 401 (-2.6A)CMK A 401 (-3.1A)CMK A 401 (-3.5A)CMK A 401 (-4.5A) | 0.68A | 3kpbC-4o9kA:16.4 | 3kpbC-4o9kA:29.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpc | 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE (Danio rerio) |
PF00551(Formyl_trans_N)PF02911(Formyl_trans_C) | 5 | HIS A 24ILE A 3VAL A 82ILE A 103ILE A 183 | None | 1.22A | 3kpbC-4qpcA:undetectable | 3kpbC-4qpcA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rer | 5'-AMP-ACTIVATEDPROTEIN KINASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00571(CBS) | 5 | ILE G 312ASP G 317THR G 200SER G 226PRO G 229 | AMP G 403 (-3.6A)AMP G 403 (-2.9A)AMP G 403 (-3.5A)AMP G 403 (-2.3A)None | 1.03A | 3kpbC-4rerG:10.5 | 3kpbC-4rerG:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awe | PUTATIVE ACETOINUTILIZATION PROTEIN,ACETOINDEHYDROGENASE (Thermusthermophilus) |
PF00571(CBS) | 5 | ILE A 120THR A 122ASP A 125THR A 8PRO A 36 | None | 0.63A | 3kpbC-5aweA:12.2 | 3kpbC-5aweA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awe | PUTATIVE ACETOINUTILIZATION PROTEIN,ACETOINDEHYDROGENASE (Thermusthermophilus) |
PF00571(CBS) | 5 | THR A 48ASP A 51VAL A 85ILE A 106PRO A 110 | None | 0.67A | 3kpbC-5aweA:12.2 | 3kpbC-5aweA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp)PF01740(STAS) | 5 | ILE A 249THR A 245VAL A 292ILE A 74SER A 75 | None | 1.15A | 3kpbC-5da0A:undetectable | 3kpbC-5da0A:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fir | 5'-3'EXORIBONUCLEASE 2HOMOLOG (Caenorhabditiselegans) |
PF03159(XRN_N) | 5 | LYS A 110ILE A 59ILE A 161SER A 158PRO A 61 | SO4 A1788 (-3.2A)NoneNoneNoneNone | 1.21A | 3kpbC-5firA:undetectable | 3kpbC-5firA:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5x | SITE-2 PROTEASE (Archaeoglobusfulgidus) |
PF00571(CBS) | 6 | ILE A 277THR A 279ASP A 282VAL A 300ILE A 321PRO A 325 | ATP A1355 (-4.1A)ATP A1355 (-2.4A)ATP A1355 (-1.9A)ATP A1355 (-3.8A)ATP A1355 (-4.5A)None | 0.56A | 3kpbC-5g5xA:17.3 | 3kpbC-5g5xA:29.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iof | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp) | 5 | ILE A 249THR A 245VAL A 292ILE A 74SER A 75 | None | 1.16A | 3kpbC-5iofA:undetectable | 3kpbC-5iofA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1d | PHOSPHATE BINDINGPROTEIN (Stenotrophomonasmaltophilia) |
PF12849(PBP_like_2) | 5 | HIS A 334THR A 289VAL A 95ILE A 23SER A 22 | None | 1.23A | 3kpbC-5j1dA:undetectable | 3kpbC-5j1dA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2e | GLUTAMATE RECEPTORIONOTROPIC,DELTA-2,GLUTAMATERECEPTOR IONOTROPIC,DELTA-2 (Rattusnorvegicus) |
PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | ILE A 284THR A 282VAL A 155ILE A 156ILE A 231 | None | 1.24A | 3kpbC-5l2eA:undetectable | 3kpbC-5l2eA:10.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m99 | ALPHA-AMYLASE (Thermotogapetrophila) |
PF00128(Alpha-amylase) | 5 | HIS B 81VAL B 120ILE B 85SER B 79PRO B 73 | None | 1.01A | 3kpbC-5m99B:undetectable | 3kpbC-5m99B:12.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5muw | PACKAGING ENZYME P4 (Pseudomonasvirus phi6) |
PF11602(NTPase_P4) | 5 | ILE A 172THR A 73ILE A 146ILE A 164SER A 165 | None | 1.27A | 3kpbC-5muwA:undetectable | 3kpbC-5muwA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvd | CBS-CP12 (Microcystisaeruginosa) |
no annotation | 6 | ILE A 52THR A 54ASP A 57LYS A 61ILE A 103PRO A 107 | None | 0.93A | 3kpbC-5nvdA:14.7 | 3kpbC-5nvdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvd | CBS-CP12 (Microcystisaeruginosa) |
no annotation | 5 | ILE A 117ASP A 122LYS A 126THR A 12VAL A 15 | None | 0.84A | 3kpbC-5nvdA:14.7 | 3kpbC-5nvdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o32 | COMPLEMENT FACTORH,COMPLEMENT FACTORH (Homo sapiens) |
PF00084(Sushi) | 5 | ILE C1120THR C1121VAL C1134ILE C1150PRO C1112 | None | 1.20A | 3kpbC-5o32C:undetectable | 3kpbC-5o32C:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swj | PROBABLE ATPSYNTHASE SPAL/MXIB (Shigellaflexneri) |
PF00006(ATP-synt_ab) | 5 | ILE A 140ASP A 144THR A 138ILE A 327PRO A 340 | None | 1.12A | 3kpbC-5swjA:undetectable | 3kpbC-5swjA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc3 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Eremotheciumgossypii) |
PF00478(IMPDH)PF00571(CBS) | 7 | ILE A 163THR A 165ASP A 168THR A 184VAL A 187ILE A 188PRO A 212 | ATP A 601 ( 4.6A)ATP A 601 (-2.7A)ATP A 601 (-2.3A)ATP A 601 (-2.8A)ATP A 601 (-4.0A)ATP A 601 (-4.2A)ATP A 601 ( 4.9A) | 0.54A | 3kpbC-5tc3A:14.9 | 3kpbC-5tc3A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txw | PEPTIDASE (Thermococcusthioreducens) |
PF01965(DJ-1_PfpI) | 5 | HIS A 101THR A 122VAL A 127ILE A 107PRO A 103 | OCS A 100 ( 3.8A)NoneNoneNoneOCS A 100 ( 4.3A) | 1.25A | 3kpbC-5txwA:undetectable | 3kpbC-5txwA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8o | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Trypanosomabrucei) |
no annotation | 5 | ILE A 144THR A 146ASP A 149THR A 164PRO A 195 | None | 0.69A | 3kpbC-5x8oA:15.6 | 3kpbC-5x8oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6all | FE(3+)-CITRATE-BINDING PROTEIN YFMC (Bacillusanthracis) |
PF01497(Peripla_BP_2) | 5 | HIS A 41ILE A 39THR A 46ILE A 161ILE A 119 | None | 1.18A | 3kpbC-6allA:undetectable | 3kpbC-6allA:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fur | HUMAN F11 T-CELLRECEPTOR (Homo sapiens) |
no annotation | 5 | HIS B 150ILE B 11THR B 12VAL B 110PRO B 148 | NoneGOL B 307 (-4.4A)NoneNoneNone | 1.20A | 3kpbC-6furB:undetectable | 3kpbC-6furB:undetectable |