SIMILAR PATTERNS OF AMINO ACIDS FOR 3KPB_A_SAMA1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger)
PF00295
(Glyco_hydro_28)
5 ASN A 253
VAL A 309
ILE A 270
ILE A 227
SER A 226
None
1.20A 3kpbA-1czfA:
undetectable
3kpbA-1czfA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001


(Methanothermobacter
thermautotrophicus)
PF02598
(Methyltrn_RNA_3)
5 ILE A  57
THR A  15
VAL A  28
ILE A  31
ILE A  10
None
1.13A 3kpbA-1k3rA:
undetectable
3kpbA-1k3rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugh PROTEIN (URACIL-DNA
GLYCOSYLASE
INHIBITOR)


(Bacillus phage
PBS2)
no annotation 5 ILE I  41
THR I  59
VAL I  29
ILE I  33
PRO I  37
None
1.09A 3kpbA-1ughI:
undetectable
3kpbA-1ughI:
24.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xkf HYPOTHETICAL PROTEIN
RV2626C


(Mycobacterium
tuberculosis)
PF00571
(CBS)
6 ILE A 113
THR A 115
ASP A 118
VAL A  12
ILE A  33
PRO A  37
None
0.97A 3kpbA-1xkfA:
16.7
3kpbA-1xkfA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv7 P-30 PROTEIN

(Rana pipiens)
PF00074
(RnaseA)
5 ILE A  47
THR A  59
VAL A  88
ILE A  37
PRO A  95
None
1.16A 3kpbA-1yv7A:
undetectable
3kpbA-1yv7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
6 ILE A 139
THR A 141
ASP A 144
THR A 160
ILE A 185
PRO A 189
None
1.04A 3kpbA-1zfjA:
15.6
3kpbA-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
6 THR A 202
ASP A 205
LYS A 208
ILE A 122
SER A 123
PRO A 126
None
1.36A 3kpbA-1zfjA:
15.6
3kpbA-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A


(Aquifex
aeolicus)
PF12804
(NTP_transf_3)
5 THR A 136
TRP A 161
ILE A 149
ILE A  85
SER A  84
None
1.14A 3kpbA-2e8bA:
undetectable
3kpbA-2e8bA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ef7 HYPOTHETICAL PROTEIN
ST2348


(Sulfurisphaera
tokodaii)
PF00571
(CBS)
6 ILE A  49
THR A  51
ASP A  54
LYS A  57
THR A  74
ILE A  98
None
1.10A 3kpbA-2ef7A:
14.5
3kpbA-2ef7A:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7i COMPLEMENT FACTOR H

(Homo sapiens)
PF00084
(Sushi)
5 ILE A1120
THR A1121
VAL A1134
ILE A1150
PRO A1112
None
1.17A 3kpbA-2g7iA:
undetectable
3kpbA-2g7iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1


(Clostridium
acetobutylicum)
PF02127
(Peptidase_M18)
5 THR A 157
VAL A 152
ILE A 151
ILE A 231
SER A 232
None
1.17A 3kpbA-2gljA:
undetectable
3kpbA-2gljA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9l CHLORIDE CHANNEL
PROTEIN 5


(Homo sapiens)
PF00571
(CBS)
5 ILE A 722
THR A 724
ASP A 727
LYS A 730
PRO A 621
ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
None
None
1.04A 3kpbA-2j9lA:
12.0
3kpbA-2j9lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9l CHLORIDE CHANNEL
PROTEIN 5


(Homo sapiens)
PF00571
(CBS)
5 ILE A 722
THR A 724
ASP A 727
SER A 618
PRO A 621
ATP  A1752 (-4.1A)
ATP  A1752 (-2.7A)
ATP  A1752 (-2.7A)
ATP  A1752 (-3.3A)
None
0.63A 3kpbA-2j9lA:
12.0
3kpbA-2j9lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE


(Vibrio cholerae)
PF00571
(CBS)
5 ILE A 139
ASP A 144
THR A  28
ILE A  52
PRO A  56
None
None
None
PO4  A   1 (-4.4A)
None
0.71A 3kpbA-2o16A:
16.8
3kpbA-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE


(Vibrio cholerae)
PF00571
(CBS)
5 ILE A 139
THR A 141
ASP A 144
ILE A  52
PRO A  56
None
PO4  A   1 (-3.0A)
None
PO4  A   1 (-4.4A)
None
0.72A 3kpbA-2o16A:
16.8
3kpbA-2o16A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I


(Schizosaccharomyces
pombe)
no annotation 6 ILE G 303
ASP G 308
THR G 191
ILE G 216
SER G 217
PRO G 220
AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
AMP  G 401 (-4.7A)
0.77A 3kpbA-2ooxG:
9.3
3kpbA-2ooxG:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A  54
THR A  56
VAL A  83
ILE A  84
PRO A 113
None
0.68A 3kpbA-2p9mA:
17.2
3kpbA-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A  54
THR A  56
VAL A  83
ILE A 109
PRO A 113
None
0.55A 3kpbA-2p9mA:
17.2
3kpbA-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 ILE A 124
ASP A 129
THR A  15
VAL A  18
PRO A  43
None
0.52A 3kpbA-2p9mA:
17.2
3kpbA-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
6 ILE A 124
THR A  15
VAL A  18
ILE A  19
ILE A  39
PRO A  43
None
0.73A 3kpbA-2p9mA:
17.2
3kpbA-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 THR A  56
THR A  80
VAL A  83
ILE A  84
PRO A 113
None
0.79A 3kpbA-2p9mA:
17.2
3kpbA-2p9mA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p9m HYPOTHETICAL PROTEIN
MJ0922


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
5 THR A  56
THR A  80
VAL A  83
ILE A 109
PRO A 113
None
0.70A 3kpbA-2p9mA:
17.2
3kpbA-2p9mA:
37.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pku PRKCA-BINDING
PROTEIN


(Rattus
norvegicus)
PF00595
(PDZ)
5 ASN A 102
ILE A  78
VAL A  86
ILE A  90
ILE A  99
None
1.16A 3kpbA-2pkuA:
undetectable
3kpbA-2pkuA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1d 2-KETO-3-DEOXY-D-ARA
BINONATE DEHYDRATASE


(Sulfolobus
solfataricus)
PF01557
(FAA_hydrolase)
5 ILE X 251
THR X 160
THR X 253
VAL X  76
PRO X  73
None
1.19A 3kpbA-2q1dX:
undetectable
3kpbA-2q1dX:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc3 CBS DOMAIN

(Nitrosomonas
europaea)
PF00571
(CBS)
7 ILE A  72
THR A  74
ASP A  77
LYS A  81
THR A  99
VAL A 102
PRO A 127
None
BR  A 171 (-4.0A)
None
None
BR  A 177 ( 4.2A)
None
None
0.80A 3kpbA-2rc3A:
18.0
3kpbA-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE


(Lactococcus
lactis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 THR A 237
VAL A 210
ILE A 276
SER A 272
PRO A 208
THR  A 237 ( 0.8A)
VAL  A 210 ( 0.6A)
ILE  A 276 ( 0.6A)
SER  A 272 ( 0.0A)
PRO  A 208 ( 1.1A)
1.24A 3kpbA-2vbfA:
undetectable
3kpbA-2vbfA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780


(Pyrococcus
horikoshii)
PF00571
(CBS)
5 ILE A 106
THR A 108
ASP A 111
THR A   8
PRO A  36
None
0.71A 3kpbA-2yzqA:
16.7
3kpbA-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780


(Pyrococcus
horikoshii)
PF00571
(CBS)
5 ILE A 172
ASP A 174
VAL A 231
ILE A 232
PRO A 256
SAM  A6075 (-3.9A)
SAM  A6075 (-3.4A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-4.6A)
1.12A 3kpbA-2yzqA:
16.7
3kpbA-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780


(Pyrococcus
horikoshii)
PF00571
(CBS)
7 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
PRO A 256
SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-4.6A)
0.60A 3kpbA-2yzqA:
16.7
3kpbA-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404


(Pyrococcus
horikoshii)
PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 ILE A 189
ASP A 334
THR A 209
ILE A 191
ILE A 362
None
1.18A 3kpbA-3af5A:
undetectable
3kpbA-3af5A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN


(Sulfolobus
solfataricus)
PF00571
(CBS)
5 ILE A 254
THR A 256
ASP A 259
VAL A 147
PRO A 172
AMP  A 278 ( 4.5A)
AMP  A 278 (-3.1A)
AMP  A 278 (-2.7A)
AMP  A 278 ( 3.6A)
AMP  A 278 (-4.7A)
0.49A 3kpbA-3ddjA:
12.6
3kpbA-3ddjA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhm UNCHARACTERIZED
PROTEIN ATU1752


(Agrobacterium
fabrum)
PF00571
(CBS)
6 ILE A  52
THR A  54
ASP A  57
THR A  79
VAL A  82
PRO A 107
AMP  A 200 (-4.0A)
AMP  A 200 (-2.9A)
AMP  A 200 (-2.9A)
AMP  A 200 (-3.5A)
AMP  A 200 ( 4.3A)
AMP  A 200 (-4.7A)
0.56A 3kpbA-3fhmA:
17.0
3kpbA-3fhmA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis)
PF06028
(DUF915)
5 ASN A 139
ILE A 102
THR A  74
VAL A  77
ILE A  78
None
1.03A 3kpbA-3fleA:
undetectable
3kpbA-3fleA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00571
(CBS)
5 ILE A 259
THR A 261
ASP A 264
THR A 285
ILE A 289
AMP  A 401 (-4.8A)
AMP  A 401 (-3.1A)
AMP  A 401 (-2.7A)
AMP  A 401 (-3.1A)
None
0.94A 3kpbA-3fnaA:
15.6
3kpbA-3fnaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00571
(CBS)
7 ILE A 259
THR A 261
ASP A 264
THR A 285
ILE A 289
ILE A 309
SER A 311
AMP  A 401 (-4.8A)
AMP  A 401 (-3.1A)
AMP  A 401 (-2.7A)
AMP  A 401 (-3.1A)
None
AMP  A 401 (-4.4A)
None
1.36A 3kpbA-3fnaA:
15.6
3kpbA-3fnaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile)
PF08282
(Hydrolase_3)
5 ASN A  80
VAL A 110
ILE A 104
ILE A 156
SER A  82
None
1.23A 3kpbA-3fzqA:
undetectable
3kpbA-3fzqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 ASN A 162
ILE A 139
VAL A 146
ILE A 149
ILE A 127
PRO A 173
None
1.22A 3kpbA-3g1uA:
undetectable
3kpbA-3g1uA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Giardia
intestinalis)
PF01116
(F_bP_aldolase)
5 ASN A  24
THR A 176
VAL A 236
ILE A 241
ILE A 252
P6T  A 327 (-3.5A)
None
None
None
None
1.22A 3kpbA-3gayA:
undetectable
3kpbA-3gayA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE


(Klebsiella
pneumoniae)
PF00571
(CBS)
5 ILE A 258
THR A 260
ASP A 263
THR A 284
ILE A 288
CMK  A   1 (-4.2A)
CMK  A   1 (-3.4A)
CMK  A   1 (-2.8A)
CMK  A   1 (-3.1A)
CMK  A   1 (-3.7A)
0.96A 3kpbA-3k2vA:
15.6
3kpbA-3k2vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2v PUTATIVE D-ARABINOSE
5-PHOSPHATE
ISOMERASE


(Klebsiella
pneumoniae)
PF00571
(CBS)
6 ILE A 258
THR A 260
ASP A 263
THR A 284
ILE A 288
ILE A 308
CMK  A   1 (-4.2A)
CMK  A   1 (-3.4A)
CMK  A   1 (-2.8A)
CMK  A   1 (-3.1A)
CMK  A   1 (-3.7A)
CMK  A   1 (-3.7A)
0.79A 3kpbA-3k2vA:
15.6
3kpbA-3k2vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
6 ILE A  51
THR A  53
ASP A  56
VAL A  94
ILE A  95
PRO A 119
ADP  A 283 ( 4.2A)
ADP  A 283 (-2.7A)
ADP  A 283 (-2.8A)
ADP  A 283 (-3.7A)
ADP  A 283 (-3.8A)
None
0.37A 3kpbA-3kh5A:
12.9
3kpbA-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
8 ILE A 193
THR A 195
ASP A 198
LYS A 201
VAL A 233
ILE A 234
ILE A 254
PRO A 258
AMP  A 282 ( 4.3A)
AMP  A 282 (-3.1A)
AMP  A 282 (-3.1A)
AMP  A 282 ( 3.7A)
AMP  A 282 (-3.8A)
AMP  A 282 (-3.9A)
AMP  A 282 (-4.1A)
None
0.88A 3kpbA-3kh5A:
12.9
3kpbA-3kh5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii)
PF00571
(CBS)
8 ILE A 269
THR A 271
ASP A 274
LYS A 277
THR A 155
VAL A 158
ILE A 159
PRO A 183
ADP  A 284 ( 4.3A)
ADP  A 284 (-3.4A)
ADP  A 284 (-2.8A)
ADP  A 284 (-3.5A)
ADP  A 284 (-3.2A)
ADP  A 284 (-3.9A)
ADP  A 284 (-4.2A)
None
0.57A 3kpbA-3kh5A:
12.9
3kpbA-3kh5A:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
12 ASN A 420
ILE A 434
THR A 436
TRP A 438
ASP A 439
LYS A 442
THR A 456
VAL A 459
ILE A 460
ILE A 480
SER A 481
PRO A 484
SAM  A1000 (-4.4A)
SAM  A1000 ( 4.2A)
SAM  A1000 (-3.4A)
SAM  A1000 (-3.1A)
SAM  A1000 (-2.6A)
SAM  A1000 ( 3.7A)
SAM  A1000 (-3.0A)
SAM  A1000 ( 3.9A)
SAM  A1000 (-3.8A)
SAM  A1000 (-4.0A)
SAM  A1000 (-3.2A)
None
0.01A 3kpbA-3kpbA:
26.9
3kpbA-3kpbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kpb UNCHARACTERIZED
PROTEIN MJ0100


(Methanocaldococcus
jannaschii)
PF00571
(CBS)
6 ILE A 495
THR A 497
ASP A 500
ILE A 399
ILE A 419
PRO A 423
None
0.63A 3kpbA-3kpbA:
26.9
3kpbA-3kpbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Ruegeria
pomeroyi)
PF03009
(GDPD)
5 ASN A 276
ILE A 292
THR A 294
VAL A  17
ILE A 303
None
1.21A 3kpbA-3l12A:
undetectable
3kpbA-3l12A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mk3 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE


(Salmonella
enterica)
no annotation 5 ASN A  27
ILE A  83
THR A  81
THR A 119
ILE A 126
None
1.24A 3kpbA-3mk3A:
undetectable
3kpbA-3mk3A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocm PUTATIVE MEMBRANE
PROTEIN


(Bordetella
parapertussis)
PF00571
(CBS)
5 THR A 443
ASP A 446
THR A 339
VAL A 344
PRO A 369
ADP  A 470 (-3.0A)
ADP  A 470 (-2.8A)
ADP  A 470 (-3.6A)
ADP  A 470 ( 4.0A)
None
0.57A 3kpbA-3ocmA:
10.2
3kpbA-3ocmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oop LIN2960 PROTEIN

(Listeria
innocua)
PF01047
(MarR)
5 THR A  58
VAL A  39
ILE A  43
ILE A  49
SER A  50
None
1.23A 3kpbA-3oopA:
undetectable
3kpbA-3oopA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN


(Bacillus
subtilis)
PF04069
(OpuAC)
5 ILE A  55
THR A  63
VAL A 261
ILE A 262
ILE A  86
None
1.13A 3kpbA-3ppoA:
undetectable
3kpbA-3ppoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN


(Bacillus virus
phi29)
PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3)
5 ASN A 266
ILE A 244
THR A 284
ILE A 242
ILE A 269
None
1.21A 3kpbA-3sucA:
undetectable
3kpbA-3sucA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN


(Methanosarcina
mazei)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
5 ILE A 131
ASP A 135
THR A 129
ILE A 326
PRO A 339
None
1.15A 3kpbA-3tgwA:
undetectable
3kpbA-3tgwA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A 137
THR A 139
ASP A 142
ILE A 183
PRO A 187
None
0.91A 3kpbA-3tsdA:
14.1
3kpbA-3tsdA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A 137
THR A 139
ASP A 142
ILE A 183
PRO A 187
None
1.19A 3kpbA-3tsdA:
14.1
3kpbA-3tsdA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B


(Enterococcus
hirae)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
5 ILE D 132
ASP D 136
THR D 130
ILE D 327
PRO D 340
None
1.17A 3kpbA-3vr5D:
undetectable
3kpbA-3vr5D:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300


(Pyrococcus
horikoshii)
PF01171
(ATP_bind_3)
5 ASN A  80
ILE A 138
THR A 134
ILE A 296
ILE A 113
None
1.06A 3kpbA-3vrhA:
undetectable
3kpbA-3vrhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7


(Homo sapiens)
PF04548
(AIG1)
5 ASN A 196
VAL A  12
ILE A  11
ILE A 189
PRO A  92
None
1.21A 3kpbA-3zjcA:
undetectable
3kpbA-3zjcA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT


(Moorella
thermoacetica)
PF03599
(CdhD)
5 ILE D 213
VAL D 249
ILE D 250
ILE D 184
PRO D 215
None
0.91A 3kpbA-4djeD:
undetectable
3kpbA-4djeD:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doh INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA


(Homo sapiens)
no annotation 5 ASN R 178
ILE R 137
THR R 135
ILE R 175
PRO R 158
None
1.19A 3kpbA-4dohR:
undetectable
3kpbA-4dohR:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE


(Chloroflexus
aurantiacus)
PF01575
(MaoC_dehydratas)
5 ASN A 228
THR A 108
ILE A  21
ILE A  81
SER A  82
None
1.19A 3kpbA-4e3eA:
undetectable
3kpbA-4e3eA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esy CBS DOMAIN
CONTAINING MEMBRANE
PROTEIN


(Sphaerobacter
thermophilus)
PF00571
(CBS)
5 ILE A 359
THR A 361
ASP A 364
THR A 407
PRO A 435
None
0.89A 3kpbA-4esyA:
15.5
3kpbA-4esyA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS


(Burkholderia
ambifaria)
PF00571
(CBS)
7 ILE A  54
THR A  56
ASP A  59
LYS A  63
THR A  81
VAL A  84
PRO A 109
AMP  A 202 (-4.1A)
AMP  A 202 (-2.9A)
AMP  A 202 (-2.6A)
AMP  A 202 ( 4.1A)
AMP  A 202 (-3.6A)
AMP  A 202 (-3.8A)
AMP  A 202 (-4.7A)
0.66A 3kpbA-4fryA:
16.7
3kpbA-4fryA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6u EC869 CDII

(Escherichia
coli)
PF07262
(CdiI)
5 ASN B  12
ILE B 121
THR B 120
VAL B 143
SER B 124
None
1.21A 3kpbA-4g6uB:
undetectable
3kpbA-4g6uB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus)
PF00144
(Beta-lactamase)
5 ASN A  97
ILE A 278
VAL A  64
ILE A  63
ILE A 347
None
1.23A 3kpbA-4gdnA:
undetectable
3kpbA-4gdnA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
5 ASN A 512
ILE A 326
THR A 488
ILE A 858
ILE A 506
None
1.12A 3kpbA-4gl2A:
undetectable
3kpbA-4gl2A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqw CBS
DOMAIN-CONTAINING
PROTEIN CBSX1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00571
(CBS)
5 ILE A 215
THR A 217
THR A  82
ILE A 108
PRO A 112
None
0.99A 3kpbA-4gqwA:
16.7
3kpbA-4gqwA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hg0 MAGNESIUM AND COBALT
EFFLUX PROTEIN CORC


(Escherichia
coli)
PF00571
(CBS)
PF03471
(CorC_HlyC)
5 THR A 180
ASP A 183
ILE A  80
SER A 101
PRO A 104
AMP  A 301 (-3.8A)
AMP  A 301 (-3.3A)
AMP  A 301 (-3.8A)
AMP  A 301 (-2.7A)
AMP  A 301 (-4.7A)
0.83A 3kpbA-4hg0A:
12.5
3kpbA-4hg0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iys METAL TRANSPORTER
CNNM2


(Homo sapiens)
PF00571
(CBS)
5 ILE A 566
THR A 568
ASP A 571
THR A 451
PRO A 482
None
0.99A 3kpbA-4iysA:
10.6
3kpbA-4iysA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9)
PF01979
(Amidohydro_1)
5 ASN A 362
ILE A  51
VAL A 394
ILE A 393
ILE A 385
ASN  A 362 ( 0.6A)
ILE  A  51 ( 0.7A)
VAL  A 394 ( 0.6A)
ILE  A 393 ( 0.4A)
ILE  A 385 ( 0.7A)
1.16A 3kpbA-4kqnA:
undetectable
3kpbA-4kqnA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2


(Homo sapiens)
PF01094
(ANF_receptor)
5 ASN B 180
THR B 200
ILE B 280
ILE B 186
PRO B 282
None
1.12A 3kpbA-4mrmB:
undetectable
3kpbA-4mrmB:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Brucella suis)
PF13561
(adh_short_C2)
5 ASN A  88
THR A  60
VAL A  68
ILE A  72
ILE A   9
None
1.13A 3kpbA-4ni5A:
undetectable
3kpbA-4ni5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN


(Salmonella
enterica)
PF00006
(ATP-synt_ab)
5 ILE A 143
ASP A 147
THR A 141
ILE A 329
PRO A 342
None
1.10A 3kpbA-4nphA:
undetectable
3kpbA-4nphA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Caldalkalibacillus
thermarum)
PF07992
(Pyr_redox_2)
5 ASN A  27
ILE A 334
ILE A   6
ILE A  33
PRO A   4
None
1.20A 3kpbA-4nwzA:
undetectable
3kpbA-4nwzA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9k ARABINOSE
5-PHOSPHATE
ISOMERASE


(Methylococcus
capsulatus)
PF00571
(CBS)
5 THR A 256
ASP A 259
THR A 280
ILE A 304
PRO A 308
CMK  A 401 (-3.4A)
CMK  A 401 (-2.6A)
CMK  A 401 (-3.1A)
CMK  A 401 (-3.5A)
CMK  A 401 (-4.5A)
0.65A 3kpbA-4o9kA:
16.3
3kpbA-4o9kA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN


(Zea mays)
PF00171
(Aldedh)
5 ASN A 454
ILE A 436
THR A 431
ASP A 279
ILE A 275
None
1.23A 3kpbA-4pxnA:
undetectable
3kpbA-4pxnA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore)
5 ASP A1350
VAL A1085
ILE A1084
ILE A1346
SER A1325
None
1.24A 3kpbA-4r04A:
undetectable
3kpbA-4r04A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xiv CHEMOTAXIS PROTEIN
CHEA


(Thermotoga
maritima)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim)
5 ILE A 358
THR A 389
VAL A 396
ILE A 399
ILE A 445
None
1.19A 3kpbA-4xivA:
undetectable
3kpbA-4xivA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE


(Thermus
thermophilus)
PF00571
(CBS)
5 ILE A 120
THR A 122
ASP A 125
THR A   8
PRO A  36
None
0.66A 3kpbA-5aweA:
12.1
3kpbA-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE


(Thermus
thermophilus)
PF00571
(CBS)
5 THR A  48
ASP A  51
VAL A  85
ILE A 106
PRO A 110
None
0.60A 3kpbA-5aweA:
12.1
3kpbA-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cec BD3460

(Bdellovibrio
bacteriovorus)
PF12796
(Ank_2)
5 ASN B 142
ILE B 149
THR B 145
VAL B 122
ILE B 124
None
1.21A 3kpbA-5cecB:
undetectable
3kpbA-5cecB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
PF01740
(STAS)
5 ILE A 249
THR A 245
VAL A 292
ILE A  74
SER A  75
None
1.16A 3kpbA-5da0A:
undetectable
3kpbA-5da0A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG


(Caenorhabditis
elegans)
PF03159
(XRN_N)
5 LYS A 110
ILE A  59
ILE A 161
SER A 158
PRO A  61
SO4  A1788 (-3.2A)
None
None
None
None
1.22A 3kpbA-5firA:
undetectable
3kpbA-5firA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6


(Arabidopsis
thaliana)
PF00808
(CBFD_NFYB_HMF)
5 ILE A  90
VAL A  68
ILE A  69
ILE A  82
SER A  83
None
None
None
None
ACT  B1152 (-2.7A)
1.19A 3kpbA-5g49A:
undetectable
3kpbA-5g49A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5x SITE-2 PROTEASE

(Archaeoglobus
fulgidus)
PF00571
(CBS)
6 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
PRO A 325
ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
None
0.56A 3kpbA-5g5xA:
17.2
3kpbA-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540


(Arabidopsis
thaliana)
PF13855
(LRR_8)
5 ASN B 344
ILE B 278
TRP B 294
ILE B 315
PRO B 303
None
1.10A 3kpbA-5hz1B:
undetectable
3kpbA-5hz1B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imt INTERMEDILYSIN

(Streptococcus
intermedius)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
5 ASN A 342
ILE A 345
THR A 343
VAL A 306
ILE A 321
None
1.23A 3kpbA-5imtA:
undetectable
3kpbA-5imtA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
5 ILE A 249
THR A 245
VAL A 292
ILE A  74
SER A  75
None
1.16A 3kpbA-5iofA:
undetectable
3kpbA-5iofA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
5 ASN A 191
ILE A  21
THR A 167
ILE A 505
ILE A 185
None
1.05A 3kpbA-5jbgA:
undetectable
3kpbA-5jbgA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5


(Gallus gallus)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
5 ASN A 504
ILE A 319
THR A 480
ILE A 832
ILE A 498
None
1.03A 3kpbA-5jcfA:
undetectable
3kpbA-5jcfA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE


(Plasmodium
falciparum)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
5 ILE A 114
ASP A 113
ILE A 516
ILE A 570
SER A 569
None
1.16A 3kpbA-5jldA:
undetectable
3kpbA-5jldA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kiq PLATELET-BINDING
GLYCOPROTEIN


(Streptococcus
sanguinis)
no annotation 5 ASN A 376
ILE A 436
THR A 437
VAL A 441
PRO A 380
None
1.01A 3kpbA-5kiqA:
undetectable
3kpbA-5kiqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa)
no annotation 6 ILE A  52
THR A  54
ASP A  57
LYS A  61
ILE A 103
PRO A 107
None
0.95A 3kpbA-5nvdA:
15.0
3kpbA-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvd CBS-CP12

(Microcystis
aeruginosa)
no annotation 5 ILE A 117
ASP A 122
LYS A 126
THR A  12
VAL A  15
None
0.85A 3kpbA-5nvdA:
15.0
3kpbA-5nvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H


(Homo sapiens)
PF00084
(Sushi)
5 ILE C1120
THR C1121
VAL C1134
ILE C1150
PRO C1112
None
1.20A 3kpbA-5o32C:
undetectable
3kpbA-5o32C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB


(Shigella
flexneri)
PF00006
(ATP-synt_ab)
5 ILE A 140
ASP A 144
THR A 138
ILE A 327
PRO A 340
None
1.10A 3kpbA-5swjA:
undetectable
3kpbA-5swjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB


(Shigella
flexneri)
PF00006
(ATP-synt_ab)
5 ILE A 140
ASP A 144
THR A 138
SER A 344
PRO A 340
None
1.20A 3kpbA-5swjA:
undetectable
3kpbA-5swjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Eremothecium
gossypii)
PF00478
(IMPDH)
PF00571
(CBS)
7 ILE A 163
THR A 165
ASP A 168
THR A 184
VAL A 187
ILE A 188
PRO A 212
ATP  A 601 ( 4.6A)
ATP  A 601 (-2.7A)
ATP  A 601 (-2.3A)
ATP  A 601 (-2.8A)
ATP  A 601 (-4.0A)
ATP  A 601 (-4.2A)
ATP  A 601 ( 4.9A)
0.54A 3kpbA-5tc3A:
14.5
3kpbA-5tc3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Trypanosoma
brucei)
no annotation 5 ASN A 193
ILE A  99
THR A 208
ASP A 211
LYS A 214
None
GTP  A 601 ( 4.2A)
GTP  A 601 (-3.9A)
GTP  A 601 (-2.8A)
GTP  A 601 (-3.0A)
1.10A 3kpbA-5x8oA:
15.3
3kpbA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Trypanosoma
brucei)
no annotation 5 ILE A 144
THR A 146
ASP A 149
THR A 164
PRO A 195
None
0.73A 3kpbA-5x8oA:
15.3
3kpbA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE


(Legionella
pneumophila)
no annotation 5 ILE A 236
VAL A 190
ILE A 191
ILE A 215
SER A 212
None
1.20A 3kpbA-6eslA:
undetectable
3kpbA-6eslA:
undetectable