SIMILAR PATTERNS OF AMINO ACIDS FOR 3KPB_A_SAMA1000
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czf | POLYGALACTURONASE II (Aspergillusniger) |
PF00295(Glyco_hydro_28) | 5 | ASN A 253VAL A 309ILE A 270ILE A 227SER A 226 | None | 1.20A | 3kpbA-1czfA:undetectable | 3kpbA-1czfA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k3r | CONSERVED PROTEINMT0001 (Methanothermobacterthermautotrophicus) |
PF02598(Methyltrn_RNA_3) | 5 | ILE A 57THR A 15VAL A 28ILE A 31ILE A 10 | None | 1.13A | 3kpbA-1k3rA:undetectable | 3kpbA-1k3rA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ugh | PROTEIN (URACIL-DNAGLYCOSYLASEINHIBITOR) (Bacillus phagePBS2) |
no annotation | 5 | ILE I 41THR I 59VAL I 29ILE I 33PRO I 37 | None | 1.09A | 3kpbA-1ughI:undetectable | 3kpbA-1ughI:24.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xkf | HYPOTHETICAL PROTEINRV2626C (Mycobacteriumtuberculosis) |
PF00571(CBS) | 6 | ILE A 113THR A 115ASP A 118VAL A 12ILE A 33PRO A 37 | None | 0.97A | 3kpbA-1xkfA:16.7 | 3kpbA-1xkfA:30.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yv7 | P-30 PROTEIN (Rana pipiens) |
PF00074(RnaseA) | 5 | ILE A 47THR A 59VAL A 88ILE A 37PRO A 95 | None | 1.16A | 3kpbA-1yv7A:undetectable | 3kpbA-1yv7A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 6 | ILE A 139THR A 141ASP A 144THR A 160ILE A 185PRO A 189 | None | 1.04A | 3kpbA-1zfjA:15.6 | 3kpbA-1zfjA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 6 | THR A 202ASP A 205LYS A 208ILE A 122SER A 123PRO A 126 | None | 1.36A | 3kpbA-1zfjA:15.6 | 3kpbA-1zfjA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e8b | PROBABLEMOLYBDOPTERIN-GUANINE DINUCLEOTIDEBIOSYNTHESIS PROTEINA (Aquifexaeolicus) |
PF12804(NTP_transf_3) | 5 | THR A 136TRP A 161ILE A 149ILE A 85SER A 84 | None | 1.14A | 3kpbA-2e8bA:undetectable | 3kpbA-2e8bA:21.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ef7 | HYPOTHETICAL PROTEINST2348 (Sulfurisphaeratokodaii) |
PF00571(CBS) | 6 | ILE A 49THR A 51ASP A 54LYS A 57THR A 74ILE A 98 | None | 1.10A | 3kpbA-2ef7A:14.5 | 3kpbA-2ef7A:33.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g7i | COMPLEMENT FACTOR H (Homo sapiens) |
PF00084(Sushi) | 5 | ILE A1120THR A1121VAL A1134ILE A1150PRO A1112 | None | 1.17A | 3kpbA-2g7iA:undetectable | 3kpbA-2g7iA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glj | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Clostridiumacetobutylicum) |
PF02127(Peptidase_M18) | 5 | THR A 157VAL A 152ILE A 151ILE A 231SER A 232 | None | 1.17A | 3kpbA-2gljA:undetectable | 3kpbA-2gljA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j9l | CHLORIDE CHANNELPROTEIN 5 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 722THR A 724ASP A 727LYS A 730PRO A 621 | ATP A1752 (-4.1A)ATP A1752 (-2.7A)ATP A1752 (-2.7A)NoneNone | 1.04A | 3kpbA-2j9lA:12.0 | 3kpbA-2j9lA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j9l | CHLORIDE CHANNELPROTEIN 5 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 722THR A 724ASP A 727SER A 618PRO A 621 | ATP A1752 (-4.1A)ATP A1752 (-2.7A)ATP A1752 (-2.7A)ATP A1752 (-3.3A)None | 0.63A | 3kpbA-2j9lA:12.0 | 3kpbA-2j9lA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o16 | ACETOIN UTILIZATIONPROTEIN ACUB,PUTATIVE (Vibrio cholerae) |
PF00571(CBS) | 5 | ILE A 139ASP A 144THR A 28ILE A 52PRO A 56 | NoneNoneNonePO4 A 1 (-4.4A)None | 0.71A | 3kpbA-2o16A:16.8 | 3kpbA-2o16A:26.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o16 | ACETOIN UTILIZATIONPROTEIN ACUB,PUTATIVE (Vibrio cholerae) |
PF00571(CBS) | 5 | ILE A 139THR A 141ASP A 144ILE A 52PRO A 56 | NonePO4 A 1 (-3.0A)NonePO4 A 1 (-4.4A)None | 0.72A | 3kpbA-2o16A:16.8 | 3kpbA-2o16A:26.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oox | HYPOTHETICAL PROTEINC1556.08C INCHROMOSOME I (Schizosaccharomycespombe) |
no annotation | 6 | ILE G 303ASP G 308THR G 191ILE G 216SER G 217PRO G 220 | AMP G 401 (-4.0A)AMP G 401 (-2.6A)AMP G 401 (-3.7A)AMP G 401 (-3.7A)AMP G 401 (-2.3A)AMP G 401 (-4.7A) | 0.77A | 3kpbA-2ooxG:9.3 | 3kpbA-2ooxG:20.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 54THR A 56VAL A 83ILE A 84PRO A 113 | None | 0.68A | 3kpbA-2p9mA:17.2 | 3kpbA-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 54THR A 56VAL A 83ILE A 109PRO A 113 | None | 0.55A | 3kpbA-2p9mA:17.2 | 3kpbA-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 124ASP A 129THR A 15VAL A 18PRO A 43 | None | 0.52A | 3kpbA-2p9mA:17.2 | 3kpbA-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 124THR A 15VAL A 18ILE A 19ILE A 39PRO A 43 | None | 0.73A | 3kpbA-2p9mA:17.2 | 3kpbA-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | THR A 56THR A 80VAL A 83ILE A 84PRO A 113 | None | 0.79A | 3kpbA-2p9mA:17.2 | 3kpbA-2p9mA:37.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p9m | HYPOTHETICAL PROTEINMJ0922 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | THR A 56THR A 80VAL A 83ILE A 109PRO A 113 | None | 0.70A | 3kpbA-2p9mA:17.2 | 3kpbA-2p9mA:37.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pku | PRKCA-BINDINGPROTEIN (Rattusnorvegicus) |
PF00595(PDZ) | 5 | ASN A 102ILE A 78VAL A 86ILE A 90ILE A 99 | None | 1.16A | 3kpbA-2pkuA:undetectable | 3kpbA-2pkuA:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1d | 2-KETO-3-DEOXY-D-ARABINONATE DEHYDRATASE (Sulfolobussolfataricus) |
PF01557(FAA_hydrolase) | 5 | ILE X 251THR X 160THR X 253VAL X 76PRO X 73 | None | 1.19A | 3kpbA-2q1dX:undetectable | 3kpbA-2q1dX:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rc3 | CBS DOMAIN (Nitrosomonaseuropaea) |
PF00571(CBS) | 7 | ILE A 72THR A 74ASP A 77LYS A 81THR A 99VAL A 102PRO A 127 | None BR A 171 (-4.0A)NoneNone BR A 177 ( 4.2A)NoneNone | 0.80A | 3kpbA-2rc3A:18.0 | 3kpbA-2rc3A:29.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbf | BRANCHED-CHAINALPHA-KETOACIDDECARBOXYLASE (Lactococcuslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 237VAL A 210ILE A 276SER A 272PRO A 208 | THR A 237 ( 0.8A)VAL A 210 ( 0.6A)ILE A 276 ( 0.6A)SER A 272 ( 0.0A)PRO A 208 ( 1.1A) | 1.24A | 3kpbA-2vbfA:undetectable | 3kpbA-2vbfA:12.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 5 | ILE A 106THR A 108ASP A 111THR A 8PRO A 36 | None | 0.71A | 3kpbA-2yzqA:16.7 | 3kpbA-2yzqA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 5 | ILE A 172ASP A 174VAL A 231ILE A 232PRO A 256 | SAM A6075 (-3.9A)SAM A6075 (-3.4A)SAM A6075 (-3.8A)SAM A6075 (-3.9A)SAM A6075 (-4.6A) | 1.12A | 3kpbA-2yzqA:16.7 | 3kpbA-2yzqA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzq | PUTATIVEUNCHARACTERIZEDPROTEIN PH1780 (Pyrococcushorikoshii) |
PF00571(CBS) | 7 | ILE A 172ASP A 177THR A 228VAL A 231ILE A 232ILE A 252PRO A 256 | SAM A6075 (-3.9A)SAM A6075 (-2.8A)SAM A6075 (-3.5A)SAM A6075 (-3.8A)SAM A6075 (-3.9A)SAM A6075 (-3.6A)SAM A6075 (-4.6A) | 0.60A | 3kpbA-2yzqA:16.7 | 3kpbA-2yzqA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3af5 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1404 (Pyrococcushorikoshii) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | ILE A 189ASP A 334THR A 209ILE A 191ILE A 362 | None | 1.18A | 3kpbA-3af5A:undetectable | 3kpbA-3af5A:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddj | CBSDOMAIN-CONTAININGPROTEIN (Sulfolobussolfataricus) |
PF00571(CBS) | 5 | ILE A 254THR A 256ASP A 259VAL A 147PRO A 172 | AMP A 278 ( 4.5A)AMP A 278 (-3.1A)AMP A 278 (-2.7A)AMP A 278 ( 3.6A)AMP A 278 (-4.7A) | 0.49A | 3kpbA-3ddjA:12.6 | 3kpbA-3ddjA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhm | UNCHARACTERIZEDPROTEIN ATU1752 (Agrobacteriumfabrum) |
PF00571(CBS) | 6 | ILE A 52THR A 54ASP A 57THR A 79VAL A 82PRO A 107 | AMP A 200 (-4.0A)AMP A 200 (-2.9A)AMP A 200 (-2.9A)AMP A 200 (-3.5A)AMP A 200 ( 4.3A)AMP A 200 (-4.7A) | 0.56A | 3kpbA-3fhmA:17.0 | 3kpbA-3fhmA:27.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fle | SE_1780 PROTEIN (Staphylococcusepidermidis) |
PF06028(DUF915) | 5 | ASN A 139ILE A 102THR A 74VAL A 77ILE A 78 | None | 1.03A | 3kpbA-3fleA:undetectable | 3kpbA-3fleA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fna | POSSIBLE ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00571(CBS) | 5 | ILE A 259THR A 261ASP A 264THR A 285ILE A 289 | AMP A 401 (-4.8A)AMP A 401 (-3.1A)AMP A 401 (-2.7A)AMP A 401 (-3.1A)None | 0.94A | 3kpbA-3fnaA:15.6 | 3kpbA-3fnaA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fna | POSSIBLE ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00571(CBS) | 7 | ILE A 259THR A 261ASP A 264THR A 285ILE A 289ILE A 309SER A 311 | AMP A 401 (-4.8A)AMP A 401 (-3.1A)AMP A 401 (-2.7A)AMP A 401 (-3.1A)NoneAMP A 401 (-4.4A)None | 1.36A | 3kpbA-3fnaA:15.6 | 3kpbA-3fnaA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fzq | PUTATIVE HYDROLASE (Clostridioidesdifficile) |
PF08282(Hydrolase_3) | 5 | ASN A 80VAL A 110ILE A 104ILE A 156SER A 82 | None | 1.23A | 3kpbA-3fzqA:undetectable | 3kpbA-3fzqA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | ASN A 162ILE A 139VAL A 146ILE A 149ILE A 127PRO A 173 | None | 1.22A | 3kpbA-3g1uA:undetectable | 3kpbA-3g1uA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gay | FRUCTOSE-BISPHOSPHATE ALDOLASE (Giardiaintestinalis) |
PF01116(F_bP_aldolase) | 5 | ASN A 24THR A 176VAL A 236ILE A 241ILE A 252 | P6T A 327 (-3.5A)NoneNoneNoneNone | 1.22A | 3kpbA-3gayA:undetectable | 3kpbA-3gayA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 5 | ILE A 258THR A 260ASP A 263THR A 284ILE A 288 | CMK A 1 (-4.2A)CMK A 1 (-3.4A)CMK A 1 (-2.8A)CMK A 1 (-3.1A)CMK A 1 (-3.7A) | 0.96A | 3kpbA-3k2vA:15.6 | 3kpbA-3k2vA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 6 | ILE A 258THR A 260ASP A 263THR A 284ILE A 288ILE A 308 | CMK A 1 (-4.2A)CMK A 1 (-3.4A)CMK A 1 (-2.8A)CMK A 1 (-3.1A)CMK A 1 (-3.7A)CMK A 1 (-3.7A) | 0.79A | 3kpbA-3k2vA:15.6 | 3kpbA-3k2vA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 51THR A 53ASP A 56VAL A 94ILE A 95PRO A 119 | ADP A 283 ( 4.2A)ADP A 283 (-2.7A)ADP A 283 (-2.8A)ADP A 283 (-3.7A)ADP A 283 (-3.8A)None | 0.37A | 3kpbA-3kh5A:12.9 | 3kpbA-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 8 | ILE A 193THR A 195ASP A 198LYS A 201VAL A 233ILE A 234ILE A 254PRO A 258 | AMP A 282 ( 4.3A)AMP A 282 (-3.1A)AMP A 282 (-3.1A)AMP A 282 ( 3.7A)AMP A 282 (-3.8A)AMP A 282 (-3.9A)AMP A 282 (-4.1A)None | 0.88A | 3kpbA-3kh5A:12.9 | 3kpbA-3kh5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 8 | ILE A 269THR A 271ASP A 274LYS A 277THR A 155VAL A 158ILE A 159PRO A 183 | ADP A 284 ( 4.3A)ADP A 284 (-3.4A)ADP A 284 (-2.8A)ADP A 284 (-3.5A)ADP A 284 (-3.2A)ADP A 284 (-3.9A)ADP A 284 (-4.2A)None | 0.57A | 3kpbA-3kh5A:12.9 | 3kpbA-3kh5A:21.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 12 | ASN A 420ILE A 434THR A 436TRP A 438ASP A 439LYS A 442THR A 456VAL A 459ILE A 460ILE A 480SER A 481PRO A 484 | SAM A1000 (-4.4A)SAM A1000 ( 4.2A)SAM A1000 (-3.4A)SAM A1000 (-3.1A)SAM A1000 (-2.6A)SAM A1000 ( 3.7A)SAM A1000 (-3.0A)SAM A1000 ( 3.9A)SAM A1000 (-3.8A)SAM A1000 (-4.0A)SAM A1000 (-3.2A)None | 0.01A | 3kpbA-3kpbA:26.9 | 3kpbA-3kpbA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 6 | ILE A 495THR A 497ASP A 500ILE A 399ILE A 419PRO A 423 | None | 0.63A | 3kpbA-3kpbA:26.9 | 3kpbA-3kpbA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l12 | PUTATIVEGLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Ruegeriapomeroyi) |
PF03009(GDPD) | 5 | ASN A 276ILE A 292THR A 294VAL A 17ILE A 303 | None | 1.21A | 3kpbA-3l12A:undetectable | 3kpbA-3l12A:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mk3 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Salmonellaenterica) |
no annotation | 5 | ASN A 27ILE A 83THR A 81THR A 119ILE A 126 | None | 1.24A | 3kpbA-3mk3A:undetectable | 3kpbA-3mk3A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocm | PUTATIVE MEMBRANEPROTEIN (Bordetellaparapertussis) |
PF00571(CBS) | 5 | THR A 443ASP A 446THR A 339VAL A 344PRO A 369 | ADP A 470 (-3.0A)ADP A 470 (-2.8A)ADP A 470 (-3.6A)ADP A 470 ( 4.0A)None | 0.57A | 3kpbA-3ocmA:10.2 | 3kpbA-3ocmA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oop | LIN2960 PROTEIN (Listeriainnocua) |
PF01047(MarR) | 5 | THR A 58VAL A 39ILE A 43ILE A 49SER A 50 | None | 1.23A | 3kpbA-3oopA:undetectable | 3kpbA-3oopA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppo | GLYCINEBETAINE/CARNITINE/CHOLINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 5 | ILE A 55THR A 63VAL A 261ILE A 262ILE A 86 | None | 1.13A | 3kpbA-3ppoA:undetectable | 3kpbA-3ppoA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3suc | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 5 | ASN A 266ILE A 244THR A 284ILE A 242ILE A 269 | None | 1.21A | 3kpbA-3sucA:undetectable | 3kpbA-3sucA:8.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tgw | V-TYPE ATP SYNTHASEBETA CHAIN (Methanosarcinamazei) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | ILE A 131ASP A 135THR A 129ILE A 326PRO A 339 | None | 1.15A | 3kpbA-3tgwA:undetectable | 3kpbA-3tgwA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 137THR A 139ASP A 142ILE A 183PRO A 187 | None | 0.91A | 3kpbA-3tsdA:14.1 | 3kpbA-3tsdA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 137THR A 139ASP A 142ILE A 183PRO A 187 | None | 1.19A | 3kpbA-3tsdA:14.1 | 3kpbA-3tsdA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr5 | V-TYPE SODIUM ATPASESUBUNIT B (Enterococcushirae) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | ILE D 132ASP D 136THR D 130ILE D 327PRO D 340 | None | 1.17A | 3kpbA-3vr5D:undetectable | 3kpbA-3vr5D:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrh | PUTATIVEUNCHARACTERIZEDPROTEIN PH0300 (Pyrococcushorikoshii) |
PF01171(ATP_bind_3) | 5 | ASN A 80ILE A 138THR A 134ILE A 296ILE A 113 | None | 1.06A | 3kpbA-3vrhA:undetectable | 3kpbA-3vrhA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zjc | GTPASE IMAP FAMILYMEMBER 7 (Homo sapiens) |
PF04548(AIG1) | 5 | ASN A 196VAL A 12ILE A 11ILE A 189PRO A 92 | None | 1.21A | 3kpbA-3zjcA:undetectable | 3kpbA-3zjcA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dje | CORRINOID/IRON-SULFUR PROTEIN SMALLSUBUNIT (Moorellathermoacetica) |
PF03599(CdhD) | 5 | ILE D 213VAL D 249ILE D 250ILE D 184PRO D 215 | None | 0.91A | 3kpbA-4djeD:undetectable | 3kpbA-4djeD:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doh | INTERLEUKIN-20RECEPTOR SUBUNITALPHA (Homo sapiens) |
no annotation | 5 | ASN R 178ILE R 137THR R 135ILE R 175PRO R 158 | None | 1.19A | 3kpbA-4dohR:undetectable | 3kpbA-4dohR:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3e | MAOC DOMAIN PROTEINDEHYDRATASE (Chloroflexusaurantiacus) |
PF01575(MaoC_dehydratas) | 5 | ASN A 228THR A 108ILE A 21ILE A 81SER A 82 | None | 1.19A | 3kpbA-4e3eA:undetectable | 3kpbA-4e3eA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | ILE A 359THR A 361ASP A 364THR A 407PRO A 435 | None | 0.89A | 3kpbA-4esyA:15.5 | 3kpbA-4esyA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fry | PUTATIVESIGNAL-TRANSDUCTIONPROTEIN WITH CBSDOMAINS (Burkholderiaambifaria) |
PF00571(CBS) | 7 | ILE A 54THR A 56ASP A 59LYS A 63THR A 81VAL A 84PRO A 109 | AMP A 202 (-4.1A)AMP A 202 (-2.9A)AMP A 202 (-2.6A)AMP A 202 ( 4.1A)AMP A 202 (-3.6A)AMP A 202 (-3.8A)AMP A 202 (-4.7A) | 0.66A | 3kpbA-4fryA:16.7 | 3kpbA-4fryA:29.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6u | EC869 CDII (Escherichiacoli) |
PF07262(CdiI) | 5 | ASN B 12ILE B 121THR B 120VAL B 143SER B 124 | None | 1.21A | 3kpbA-4g6uB:undetectable | 3kpbA-4g6uB:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gdn | PROTEIN FLP (Staphylococcusaureus) |
PF00144(Beta-lactamase) | 5 | ASN A 97ILE A 278VAL A 64ILE A 63ILE A 347 | None | 1.23A | 3kpbA-4gdnA:undetectable | 3kpbA-4gdnA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl2 | INTERFERON-INDUCEDHELICASE CDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | ASN A 512ILE A 326THR A 488ILE A 858ILE A 506 | None | 1.12A | 3kpbA-4gl2A:undetectable | 3kpbA-4gl2A:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqw | CBSDOMAIN-CONTAININGPROTEIN CBSX1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00571(CBS) | 5 | ILE A 215THR A 217THR A 82ILE A 108PRO A 112 | None | 0.99A | 3kpbA-4gqwA:16.7 | 3kpbA-4gqwA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hg0 | MAGNESIUM AND COBALTEFFLUX PROTEIN CORC (Escherichiacoli) |
PF00571(CBS)PF03471(CorC_HlyC) | 5 | THR A 180ASP A 183ILE A 80SER A 101PRO A 104 | AMP A 301 (-3.8A)AMP A 301 (-3.3A)AMP A 301 (-3.8A)AMP A 301 (-2.7A)AMP A 301 (-4.7A) | 0.83A | 3kpbA-4hg0A:12.5 | 3kpbA-4hg0A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iys | METAL TRANSPORTERCNNM2 (Homo sapiens) |
PF00571(CBS) | 5 | ILE A 566THR A 568ASP A 571THR A 451PRO A 482 | None | 0.99A | 3kpbA-4iysA:10.6 | 3kpbA-4iysA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqn | D-HYDANTOINASE (Bacillus sp.AR9) |
PF01979(Amidohydro_1) | 5 | ASN A 362ILE A 51VAL A 394ILE A 393ILE A 385 | ASN A 362 ( 0.6A)ILE A 51 ( 0.7A)VAL A 394 ( 0.6A)ILE A 393 ( 0.4A)ILE A 385 ( 0.7A) | 1.16A | 3kpbA-4kqnA:undetectable | 3kpbA-4kqnA:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mrm | GAMMA-AMINOBUTYRICACID TYPE B RECEPTORSUBUNIT 2 (Homo sapiens) |
PF01094(ANF_receptor) | 5 | ASN B 180THR B 200ILE B 280ILE B 186PRO B 282 | None | 1.12A | 3kpbA-4mrmB:undetectable | 3kpbA-4mrmB:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ni5 | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Brucella suis) |
PF13561(adh_short_C2) | 5 | ASN A 88THR A 60VAL A 68ILE A 72ILE A 9 | None | 1.13A | 3kpbA-4ni5A:undetectable | 3kpbA-4ni5A:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nph | PROBABLE SECRETIONSYSTEM APPARATUS ATPSYNTHASE SSAN (Salmonellaenterica) |
PF00006(ATP-synt_ab) | 5 | ILE A 143ASP A 147THR A 141ILE A 329PRO A 342 | None | 1.10A | 3kpbA-4nphA:undetectable | 3kpbA-4nphA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwz | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE (Caldalkalibacillusthermarum) |
PF07992(Pyr_redox_2) | 5 | ASN A 27ILE A 334ILE A 6ILE A 33PRO A 4 | None | 1.20A | 3kpbA-4nwzA:undetectable | 3kpbA-4nwzA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9k | ARABINOSE5-PHOSPHATEISOMERASE (Methylococcuscapsulatus) |
PF00571(CBS) | 5 | THR A 256ASP A 259THR A 280ILE A 304PRO A 308 | CMK A 401 (-3.4A)CMK A 401 (-2.6A)CMK A 401 (-3.1A)CMK A 401 (-3.5A)CMK A 401 (-4.5A) | 0.65A | 3kpbA-4o9kA:16.3 | 3kpbA-4o9kA:29.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pxn | UNCHARACTERIZEDPROTEIN (Zea mays) |
PF00171(Aldedh) | 5 | ASN A 454ILE A 436THR A 431ASP A 279ILE A 275 | None | 1.23A | 3kpbA-4pxnA:undetectable | 3kpbA-4pxnA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r04 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80)PF12918(TcdB_N)PF12919(TcdA_TcdB)PF12920(TcdA_TcdB_pore) | 5 | ASP A1350VAL A1085ILE A1084ILE A1346SER A1325 | None | 1.24A | 3kpbA-4r04A:undetectable | 3kpbA-4r04A:5.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xiv | CHEMOTAXIS PROTEINCHEA (Thermotogamaritima) |
PF02518(HATPase_c)PF02895(H-kinase_dim) | 5 | ILE A 358THR A 389VAL A 396ILE A 399ILE A 445 | None | 1.19A | 3kpbA-4xivA:undetectable | 3kpbA-4xivA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awe | PUTATIVE ACETOINUTILIZATION PROTEIN,ACETOINDEHYDROGENASE (Thermusthermophilus) |
PF00571(CBS) | 5 | ILE A 120THR A 122ASP A 125THR A 8PRO A 36 | None | 0.66A | 3kpbA-5aweA:12.1 | 3kpbA-5aweA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awe | PUTATIVE ACETOINUTILIZATION PROTEIN,ACETOINDEHYDROGENASE (Thermusthermophilus) |
PF00571(CBS) | 5 | THR A 48ASP A 51VAL A 85ILE A 106PRO A 110 | None | 0.60A | 3kpbA-5aweA:12.1 | 3kpbA-5aweA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cec | BD3460 (Bdellovibriobacteriovorus) |
PF12796(Ank_2) | 5 | ASN B 142ILE B 149THR B 145VAL B 122ILE B 124 | None | 1.21A | 3kpbA-5cecB:undetectable | 3kpbA-5cecB:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp)PF01740(STAS) | 5 | ILE A 249THR A 245VAL A 292ILE A 74SER A 75 | None | 1.16A | 3kpbA-5da0A:undetectable | 3kpbA-5da0A:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fir | 5'-3'EXORIBONUCLEASE 2HOMOLOG (Caenorhabditiselegans) |
PF03159(XRN_N) | 5 | LYS A 110ILE A 59ILE A 161SER A 158PRO A 61 | SO4 A1788 (-3.2A)NoneNoneNoneNone | 1.22A | 3kpbA-5firA:undetectable | 3kpbA-5firA:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g49 | NUCLEARTRANSCRIPTION FACTORY SUBUNIT B-6 (Arabidopsisthaliana) |
PF00808(CBFD_NFYB_HMF) | 5 | ILE A 90VAL A 68ILE A 69ILE A 82SER A 83 | NoneNoneNoneNoneACT B1152 (-2.7A) | 1.19A | 3kpbA-5g49A:undetectable | 3kpbA-5g49A:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5x | SITE-2 PROTEASE (Archaeoglobusfulgidus) |
PF00571(CBS) | 6 | ILE A 277THR A 279ASP A 282VAL A 300ILE A 321PRO A 325 | ATP A1355 (-4.1A)ATP A1355 (-2.4A)ATP A1355 (-1.9A)ATP A1355 (-3.8A)ATP A1355 (-4.5A)None | 0.56A | 3kpbA-5g5xA:17.2 | 3kpbA-5g5xA:29.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hz1 | PROBABLE LRRRECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASEAT4G26540 (Arabidopsisthaliana) |
PF13855(LRR_8) | 5 | ASN B 344ILE B 278TRP B 294ILE B 315PRO B 303 | None | 1.10A | 3kpbA-5hz1B:undetectable | 3kpbA-5hz1B:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5imt | INTERMEDILYSIN (Streptococcusintermedius) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 5 | ASN A 342ILE A 345THR A 343VAL A 306ILE A 321 | None | 1.23A | 3kpbA-5imtA:undetectable | 3kpbA-5imtA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iof | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp) | 5 | ILE A 249THR A 245VAL A 292ILE A 74SER A 75 | None | 1.16A | 3kpbA-5iofA:undetectable | 3kpbA-5iofA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbg | LGP2 (Gallus gallus) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | ASN A 191ILE A 21THR A 167ILE A 505ILE A 185 | None | 1.05A | 3kpbA-5jbgA:undetectable | 3kpbA-5jbgA:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jcf | MELANOMADIFFERENTIATIONASSOCIATED PROTEIN-5 (Gallus gallus) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | ASN A 504ILE A 319THR A 480ILE A 832ILE A 498 | None | 1.03A | 3kpbA-5jcfA:undetectable | 3kpbA-5jcfA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jld | ARGINYL-TRNASYNTHETASE, PUTATIVE (Plasmodiumfalciparum) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 5 | ILE A 114ASP A 113ILE A 516ILE A 570SER A 569 | None | 1.16A | 3kpbA-5jldA:undetectable | 3kpbA-5jldA:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kiq | PLATELET-BINDINGGLYCOPROTEIN (Streptococcussanguinis) |
no annotation | 5 | ASN A 376ILE A 436THR A 437VAL A 441PRO A 380 | None | 1.01A | 3kpbA-5kiqA:undetectable | 3kpbA-5kiqA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvd | CBS-CP12 (Microcystisaeruginosa) |
no annotation | 6 | ILE A 52THR A 54ASP A 57LYS A 61ILE A 103PRO A 107 | None | 0.95A | 3kpbA-5nvdA:15.0 | 3kpbA-5nvdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvd | CBS-CP12 (Microcystisaeruginosa) |
no annotation | 5 | ILE A 117ASP A 122LYS A 126THR A 12VAL A 15 | None | 0.85A | 3kpbA-5nvdA:15.0 | 3kpbA-5nvdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o32 | COMPLEMENT FACTORH,COMPLEMENT FACTORH (Homo sapiens) |
PF00084(Sushi) | 5 | ILE C1120THR C1121VAL C1134ILE C1150PRO C1112 | None | 1.20A | 3kpbA-5o32C:undetectable | 3kpbA-5o32C:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swj | PROBABLE ATPSYNTHASE SPAL/MXIB (Shigellaflexneri) |
PF00006(ATP-synt_ab) | 5 | ILE A 140ASP A 144THR A 138ILE A 327PRO A 340 | None | 1.10A | 3kpbA-5swjA:undetectable | 3kpbA-5swjA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swj | PROBABLE ATPSYNTHASE SPAL/MXIB (Shigellaflexneri) |
PF00006(ATP-synt_ab) | 5 | ILE A 140ASP A 144THR A 138SER A 344PRO A 340 | None | 1.20A | 3kpbA-5swjA:undetectable | 3kpbA-5swjA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc3 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Eremotheciumgossypii) |
PF00478(IMPDH)PF00571(CBS) | 7 | ILE A 163THR A 165ASP A 168THR A 184VAL A 187ILE A 188PRO A 212 | ATP A 601 ( 4.6A)ATP A 601 (-2.7A)ATP A 601 (-2.3A)ATP A 601 (-2.8A)ATP A 601 (-4.0A)ATP A 601 (-4.2A)ATP A 601 ( 4.9A) | 0.54A | 3kpbA-5tc3A:14.5 | 3kpbA-5tc3A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8o | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Trypanosomabrucei) |
no annotation | 5 | ASN A 193ILE A 99THR A 208ASP A 211LYS A 214 | NoneGTP A 601 ( 4.2A)GTP A 601 (-3.9A)GTP A 601 (-2.8A)GTP A 601 (-3.0A) | 1.10A | 3kpbA-5x8oA:15.3 | 3kpbA-5x8oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8o | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Trypanosomabrucei) |
no annotation | 5 | ILE A 144THR A 146ASP A 149THR A 164PRO A 195 | None | 0.73A | 3kpbA-5x8oA:15.3 | 3kpbA-5x8oA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6esl | BACTERIAL LEUCYLAMINOPEPTIDASE (Legionellapneumophila) |
no annotation | 5 | ILE A 236VAL A 190ILE A 191ILE A 215SER A 212 | None | 1.20A | 3kpbA-6eslA:undetectable | 3kpbA-6eslA:undetectable |