SIMILAR PATTERNS OF AMINO ACIDS FOR 3KP6_B_SALB3008

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Staphylococcus
aureus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 GLU A 171
VAL A 169
VAL A  75
ALA A  68
 None
 0.98A 3kp6B-1hskA:
undetectable		 3kp6B-1hskA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens) 		PF00856
(SET)
PF02493
(MORN) 		4 GLU A 214
VAL A 216
VAL A 236
ARG A 215
 None
 0.97A 3kp6B-1mt6A:
undetectable		 3kp6B-1mt6A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlf REGULATORY PROTEIN
REPA

(Escherichia
coli) 		PF13481
(AAA_25) 		4 GLU A 150
VAL A 201
VAL A  36
ALA A 180
 None
 1.06A 3kp6B-1nlfA:
0.9		 3kp6B-1nlfA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npr TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Aquifex
aeolicus) 		PF00467
(KOW)
PF02357
(NusG)
PF07009
(NusG_II) 		4 VAL A  18
GLN A  17
VAL A 163
ALA A  15
 None
 0.98A 3kp6B-1nprA:
undetectable		 3kp6B-1nprA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLU A 627
VAL A 629
VAL A 533
ALA A 622
 None
 1.05A 3kp6B-1s5jA:
1.5		 3kp6B-1s5jA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 GLU A 394
VAL A 200
VAL A 469
ALA A 446
 None
 1.05A 3kp6B-1t1eA:
0.0		 3kp6B-1t1eA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A  35
HIS A  34
VAL A  80
ALA A 156
 None
 0.94A 3kp6B-1u3tA:
undetectable		 3kp6B-1u3tA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		4 GLU A  42
HIS A   8
VAL A  11
ALA A  40
 None
 0.89A 3kp6B-1v9sA:
0.0		 3kp6B-1v9sA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 GLU A 271
HIS A 268
VAL A 194
ALA A 287
 None
FE  A 400 (-3.4A)
None
None
 1.02A 3kp6B-1vljA:
0.9		 3kp6B-1vljA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp6 CYCLIC-NUCLEOTIDE
BINDING DOMAIN OF
MESORHIZOBIUM LOTI
CNG POTASSIUM
CHANNEL

(Mesorhizobium
loti) 		PF00027
(cNMP_binding) 		4 GLU A 289
VAL A 282
VAL A 275
ALA A 294
 None
CMP  A 368 (-4.4A)
None
None
 0.91A 3kp6B-1vp6A:
undetectable		 3kp6B-1vp6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdv HYPOTHETICAL PROTEIN
APE2540

(Aeropyrum
pernix) 		PF04073
(tRNA_edit) 		4 GLU A  73
VAL A 150
VAL A  79
ALA A  75
 None
 0.97A 3kp6B-1wdvA:
undetectable		 3kp6B-1wdvA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 HIS A 160
VAL A 159
VAL A 166
ALA A 138
 None
 1.02A 3kp6B-1wytA:
undetectable		 3kp6B-1wytA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 HIS A 412
VAL A 413
VAL A  29
ALA A 440
 None
 0.72A 3kp6B-1xr6A:
undetectable		 3kp6B-1xr6A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLU A 777
HIS A 803
GLN A 805
VAL A 807
 None
 1.03A 3kp6B-2b49A:
undetectable		 3kp6B-2b49A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 GLU A 958
VAL A1040
VAL A1004
ALA A 968
 None
 0.77A 3kp6B-2b5mA:
undetectable		 3kp6B-2b5mA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLU A1213
GLN A1205
VAL A1204
ALA A1193
 None
 0.91A 3kp6B-2bruA:
undetectable		 3kp6B-2bruA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07350
(DUF1479) 		4 HIS A 340
VAL A 343
VAL A  82
ALA A  88
 None
 1.03A 3kp6B-2csgA:
undetectable		 3kp6B-2csgA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		4 GLU A 200
VAL A 185
VAL A 341
ALA A 290
 None
 0.98A 3kp6B-2d2xA:
undetectable		 3kp6B-2d2xA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 HIS A 361
VAL A 381
VAL A 411
ALA A 394
 None
 0.94A 3kp6B-2ecfA:
undetectable		 3kp6B-2ecfA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		4 GLU A 276
VAL A 279
VAL A 264
ALA A  26
 None
 0.97A 3kp6B-2ef4A:
undetectable		 3kp6B-2ef4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 GLU A  15
VAL A 337
GLN A  16
ALA A 349
ARG A  17
 None
 1.33A 3kp6B-2eyqA:
undetectable		 3kp6B-2eyqA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		4 GLU A 311
VAL A  77
VAL A  84
ALA A 313
 None
 0.99A 3kp6B-2g36A:
undetectable		 3kp6B-2g36A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		5 GLU A 113
HIS A 114
VAL A 115
VAL A 210
ALA A 107
 None
 1.28A 3kp6B-2hp3A:
undetectable		 3kp6B-2hp3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 GLU A  93
VAL A  95
VAL A 142
ALA A 146
 None
 1.00A 3kp6B-2ipfA:
undetectable		 3kp6B-2ipfA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv5 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF10052
(DUF2288) 		4 GLU A  50
VAL A  60
VAL A  92
ALA A  53
 None
 1.04A 3kp6B-2lv5A:
undetectable		 3kp6B-2lv5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE

(Pseudomonas sp.
101) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLU A 152
VAL A 155
ALA A 205
ARG A 209
 None
 0.99A 3kp6B-2nadA:
undetectable		 3kp6B-2nadA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 GLU A 279
HIS A 275
VAL A 288
ALA A 281
 None
 0.89A 3kp6B-2ohhA:
undetectable		 3kp6B-2ohhA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 HIS A  58
GLN A  40
VAL A  41
ALA A  51
 None
EDO  A 502 (-4.1A)
EDO  A 502 (-4.8A)
None
 1.05A 3kp6B-2q14A:
undetectable		 3kp6B-2q14A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		4 GLU A 133
VAL A 105
VAL A 293
ALA A 130
 None
 1.04A 3kp6B-2ql3A:
undetectable		 3kp6B-2ql3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A  34
VAL A  55
GLN A  58
ALA A   9
 None
 1.01A 3kp6B-2qz9A:
undetectable		 3kp6B-2qz9A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 GLU A 840
VAL A 796
VAL A 645
ALA A 662
 None
 1.06A 3kp6B-3c10A:
undetectable		 3kp6B-3c10A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 GLU P 361
VAL P 363
ALA P  98
ARG P 102
 None
 1.05A 3kp6B-3c5wP:
undetectable		 3kp6B-3c5wP:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgl GFP-LIKE FLUORESCENT
CHROMOPROTEIN
DSFP483

(Discosoma
striata) 		PF01353
(GFP) 		4 GLU A 148
HIS A 194
VAL A  73
ALA A 218
 None
 1.05A 3kp6B-3cglA:
undetectable		 3kp6B-3cglA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		4 GLU A 197
VAL A 181
VAL A 205
ALA A 210
 None
 1.06A 3kp6B-3cj8A:
undetectable		 3kp6B-3cj8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM

(Lactococcus
lactis) 		PF03610
(EIIA-man) 		4 GLU C  54
VAL C  77
VAL C   6
ALA C  52
 None
 1.06A 3kp6B-3cr3C:
undetectable		 3kp6B-3cr3C:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 GLU P 390
VAL P 387
VAL P 342
ALA P 393
 None
 0.99A 3kp6B-3fg2P:
undetectable		 3kp6B-3fg2P:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		4 GLU A 227
VAL A 283
GLN A 286
VAL A 288
 None
 0.90A 3kp6B-3fgqA:
undetectable		 3kp6B-3fgqA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 HIS A  96
GLN A 261
VAL A 256
ALA A 104
 None
 1.02A 3kp6B-3g8mA:
undetectable		 3kp6B-3g8mA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 HIS A 496
VAL A 495
VAL A 466
ALA A 445
 None
 0.79A 3kp6B-3hwwA:
undetectable		 3kp6B-3hwwA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0y PUTATIVE POLYKETIDE
CYCLASE

(Xanthomonas
campestris) 		PF12680
(SnoaL_2) 		5 GLU A  34
VAL A  36
GLN A 120
ALA A  30
ARG A  49
 None
 1.34A 3kp6B-3i0yA:
undetectable		 3kp6B-3i0yA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ios DISULFIDE BOND
FORMING PROTEIN
(DSBF)

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 VAL A 119
GLN A 116
VAL A 112
ALA A 131
 None
 1.04A 3kp6B-3iosA:
undetectable		 3kp6B-3iosA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S2,
MITOCHONDRIAL

(Bos taurus) 		PF00318
(Ribosomal_S2) 		4 HIS B  79
VAL B  78
VAL B  70
ALA B 111
 None
 0.93A 3kp6B-3jd5B:
undetectable		 3kp6B-3jd5B:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lof HEAT SHOCK 70 KDA
PROTEIN 1

(Homo sapiens) 		PF00012
(HSP70) 		4 GLU A 600
VAL A 602
VAL A 577
ALA A 546
 None
 1.04A 3kp6B-3lofA:
2.1		 3kp6B-3lofA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwa SECRETED
THIOL-DISULFIDE
ISOMERASE

(Corynebacterium
glutamicum) 		PF00578
(AhpC-TSA) 		4 GLU A  50
VAL A 191
VAL A 199
ALA A 185
 None
 0.87A 3kp6B-3lwaA:
undetectable		 3kp6B-3lwaA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 GLU A 105
HIS A 101
VAL A 114
ALA A 107
 None
 1.00A 3kp6B-3nnkA:
undetectable		 3kp6B-3nnkA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqn UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		PF12723
(DUF3809) 		4 HIS A 113
VAL A  90
GLN A 111
ALA A   5
 None
 1.06A 3kp6B-3nqnA:
undetectable		 3kp6B-3nqnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		4 GLU A 215
GLN A 233
VAL A 231
ALA A 217
 None
 1.00A 3kp6B-3pl2A:
undetectable		 3kp6B-3pl2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8y 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		4 GLU A 200
VAL A 184
VAL A 208
ALA A 213
 None
 1.00A 3kp6B-3r8yA:
undetectable		 3kp6B-3r8yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 HIS A 454
VAL A 457
VAL A 507
ALA A 476
 None
 1.00A 3kp6B-3rg2A:
undetectable		 3kp6B-3rg2A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		4 GLU B1082
VAL B1080
VAL B1047
ALA B1004
 None
 0.99A 3kp6B-3u44B:
undetectable		 3kp6B-3u44B:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 GLU A 745
VAL A 732
VAL A 736
ALA A 743
 None
 1.04A 3kp6B-4a0hA:
undetectable		 3kp6B-4a0hA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 GLU A 338
HIS A 226
VAL A 260
ALA A 252
 None
 1.06A 3kp6B-4a5wA:
undetectable		 3kp6B-4a5wA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 GLU A  48
GLN A   7
VAL A  83
ALA A   5
 None
 1.03A 3kp6B-4bs9A:
3.6		 3kp6B-4bs9A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 HIS A 583
GLN A 422
VAL A 424
ALA A 393
 None
 1.00A 3kp6B-4bugA:
undetectable		 3kp6B-4bugA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLU X 385
VAL X 319
VAL X 314
ALA X 382
 None
 1.06A 3kp6B-4crmX:
undetectable		 3kp6B-4crmX:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		4 HIS A 507
VAL A 506
VAL A 523
ALA A 503
 None
 0.91A 3kp6B-4drsA:
undetectable		 3kp6B-4drsA:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eju TRANSCRIPTIONAL
REGULATOR TCAR

(Staphylococcus
epidermidis) 		PF12802
(MarR_2) 		5 GLU A  39
HIS A  42
GLN A  61
VAL A  63
ARG A  71
 None
 1.28A 3kp6B-4ejuA:
19.6		 3kp6B-4ejuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eju TRANSCRIPTIONAL
REGULATOR TCAR

(Staphylococcus
epidermidis) 		PF12802
(MarR_2) 		5 GLU A  39
HIS A  42
VAL A  43
ALA A  67
ARG A  71
 None
 0.54A 3kp6B-4ejuA:
19.6		 3kp6B-4ejuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eju TRANSCRIPTIONAL
REGULATOR TCAR

(Staphylococcus
epidermidis) 		PF12802
(MarR_2) 		5 GLU A  39
HIS A  42
VAL A  43
GLN A  61
ARG A  71
 None
 1.10A 3kp6B-4ejuA:
19.6		 3kp6B-4ejuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eju TRANSCRIPTIONAL
REGULATOR TCAR

(Staphylococcus
epidermidis) 		PF12802
(MarR_2) 		5 GLU A  39
HIS A  42
VAL A  63
ALA A  67
ARG A  71
 None
 0.72A 3kp6B-4ejuA:
19.6		 3kp6B-4ejuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		4 GLU A 394
HIS A 390
GLN A 393
ALA A 396
 None
 0.85A 3kp6B-4f3eA:
undetectable		 3kp6B-4f3eA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphaerobacter
thermophilus) 		PF00903
(Glyoxalase) 		4 HIS A  12
GLN A  59
VAL A  52
ALA A  56
 None
 1.04A 3kp6B-4hc5A:
undetectable		 3kp6B-4hc5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 GLU A 259
GLN A  63
VAL A  84
ALA A  66
 None
 0.99A 3kp6B-4hgvA:
undetectable		 3kp6B-4hgvA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 GLU A 289
VAL A 326
VAL A 256
ARG A 107
 CTT  A 401 (-2.9A)
None
None
None
 1.07A 3kp6B-4hu0A:
undetectable		 3kp6B-4hu0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if4 RESPONSE REGULATOR
PROTEIN VRAR

(Staphylococcus
aureus) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 GLU A  12
VAL A  14
ALA A  35
ARG A  15
 None
 1.02A 3kp6B-4if4A:
6.3		 3kp6B-4if4A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		4 GLU A 357
HIS A 359
VAL A 387
ALA A 391
 None
 0.85A 3kp6B-4ijmA:
undetectable		 3kp6B-4ijmA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A 294
VAL A 289
VAL A  84
ALA A 142
 None
 0.96A 3kp6B-4jbhA:
undetectable		 3kp6B-4jbhA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLU A 301
VAL A 264
VAL A 240
ALA A 279
 None
 1.00A 3kp6B-4lxfA:
undetectable		 3kp6B-4lxfA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		4 HIS A 329
VAL A 307
ALA A 310
ARG A 314
 None
 0.92A 3kp6B-4n0qA:
undetectable		 3kp6B-4n0qA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLU A 151
HIS A 197
VAL A 309
ALA A 221
 None
 1.06A 3kp6B-4oy4A:
undetectable		 3kp6B-4oy4A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 HIS A 347
VAL A 282
VAL A 329
ALA A 310
 None
 0.89A 3kp6B-4pxbA:
undetectable		 3kp6B-4pxbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		4 HIS A  31
VAL A   5
VAL A  56
ALA A  20
 None
 0.78A 3kp6B-4pzkA:
undetectable		 3kp6B-4pzkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 856
VAL A 863
VAL A 787
ALA A 804
 None
 1.01A 3kp6B-4qpmA:
1.5		 3kp6B-4qpmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		4 GLU A 348
GLN A 347
VAL A 318
ALA A 351
 None
 1.07A 3kp6B-4r8lA:
undetectable		 3kp6B-4r8lA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ro1 DIS3-LIKE
EXONUCLEASE 2

(Schizosaccharomyces
pombe) 		no annotation 4 GLU B 663
HIS B 664
VAL B 536
ALA B 657
 None
 1.02A 3kp6B-4ro1B:
2.4		 3kp6B-4ro1B:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 GLU B  66
HIS B  65
ALA B  86
ARG B  69
 None
 0.99A 3kp6B-4tx2B:
undetectable		 3kp6B-4tx2B:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		4 VAL A 370
GLN A 346
VAL A 350
ALA A 384
 None
 0.98A 3kp6B-4xwuA:
undetectable		 3kp6B-4xwuA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLU A 153
VAL A 156
ALA A 206
ARG A 210
 None
 0.96A 3kp6B-4xybA:
undetectable		 3kp6B-4xybA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 524
GLN A 276
VAL A 512
ALA A 528
 None
 0.94A 3kp6B-5ck0A:
0.2		 3kp6B-5ck0A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L18

(Deinococcus
radiodurans) 		PF00861
(Ribosomal_L18p) 		4 HIS L  37
VAL L  71
ALA L  68
ARG L  33
 C  Y  30 ( 3.1A)
None
None
None
 1.05A 3kp6B-5dm6L:
undetectable		 3kp6B-5dm6L:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		4 GLU A 348
GLN A 347
VAL A 318
ALA A 351
 None
 1.07A 3kp6B-5dneA:
undetectable		 3kp6B-5dneA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLU A 231
HIS A 247
GLN A 267
ALA A 243
ARG A 266
 None
 1.12A 3kp6B-5fkcA:
undetectable		 3kp6B-5fkcA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 GLU A 280
VAL A 243
VAL A 219
ALA A 258
 None
 0.94A 3kp6B-5h2tA:
undetectable		 3kp6B-5h2tA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 GLU A1049
VAL A1053
GLN A1010
ALA A1005
 None
 1.02A 3kp6B-5h2vA:
undetectable		 3kp6B-5h2vA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 HIS A 380
VAL A  25
VAL A 207
ALA A  43
 None
 1.07A 3kp6B-5h8wA:
undetectable		 3kp6B-5h8wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		4 HIS A 105
VAL A 106
GLN A 107
ALA A 387
 None
 0.90A 3kp6B-5j7uA:
undetectable		 3kp6B-5j7uA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 GLU A 716
HIS A 719
GLN A 720
VAL A 708
 None
 1.04A 3kp6B-5lu4A:
undetectable		 3kp6B-5lu4A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 GLU A 657
VAL A 670
ALA A 767
ARG A 668
 None
 1.02A 3kp6B-5n8oA:
2.2		 3kp6B-5n8oA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 4 GLU A 900
HIS A 901
VAL A 902
ALA A 808
 None
 1.06A 3kp6B-5nprA:
undetectable		 3kp6B-5nprA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		4 VAL A 269
GLN A 229
ALA A 222
ARG A 267
 None
 1.07A 3kp6B-5ntfA:
undetectable		 3kp6B-5ntfA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S4

(Mycolicibacterium
smegmatis) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 HIS D 178
VAL D 177
GLN D 167
VAL D 169
 None
 1.02A 3kp6B-5o5jD:
undetectable		 3kp6B-5o5jD:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile) 		no annotation 4 GLU A  28
VAL A 125
VAL A   4
ALA A  30
 None
 1.05A 3kp6B-5ol2A:
undetectable		 3kp6B-5ol2A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 GLU A 111
VAL A 172
VAL A 123
ALA A  94
 SAH  A 502 ( 4.8A)
None
None
None
 1.05A 3kp6B-5t67A:
undetectable		 3kp6B-5t67A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 370
GLN A 346
VAL A 350
ALA A 384
 None
 0.98A 3kp6B-5tc3A:
undetectable		 3kp6B-5tc3A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 GLU A 381
VAL A 347
VAL A 292
ALA A 344
 None
 0.87A 3kp6B-5ucmA:
0.5		 3kp6B-5ucmA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4z RIBOFLAVIN LYASE

(Herbiconiux) 		no annotation 4 GLU A 375
VAL A 369
VAL A 410
ALA A 377
 None
 1.01A 3kp6B-5w4zA:
undetectable		 3kp6B-5w4zA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 HIS A 363
VAL A 384
VAL A 414
ALA A 397
 None
 1.01A 3kp6B-5yp3A:
undetectable		 3kp6B-5yp3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 4 GLU A 472
VAL A 476
VAL A 463
ALA A 539
 None
 1.03A 3kp6B-5ze3A:
undetectable		 3kp6B-5ze3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-) 		no annotation 4 GLU A  66
VAL A  46
VAL A  58
ALA A  64
 None
None
LLP  A  34 ( 4.5A)
None
 1.02A 3kp6B-6a2fA:
undetectable		 3kp6B-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA

(Pyrococcus
furiosus) 		no annotation 4 GLU K   5
VAL K  85
VAL K  22
ALA K   8
 None
 1.01A 3kp6B-6cfwK:
undetectable		 3kp6B-6cfwK:
20.28