SIMILAR PATTERNS OF AMINO ACIDS FOR 3KP6_B_SALB3007_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 THR A 121
ALA A 122
LEU A 124
ALA A 126
SER A 127
 None
 1.41A 3kp6B-1e5wA:
0.0		 3kp6B-1e5wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 THR A 121
ALA A 122
LEU A 124
ALA A 126
SER A 127
 None
 1.47A 3kp6B-1ef1A:
0.0		 3kp6B-1ef1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezi CMP-N-ACETYLNEURAMIN
IC ACID SYNTHETASE

(Neisseria
meningitidis) 		PF02348
(CTP_transf_3) 		5 ASN A  96
THR A 183
ALA A 184
LEU A 186
ALA A 188
 None
 1.40A 3kp6B-1eziA:
0.0		 3kp6B-1eziA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 THR A 134
ALA A 135
LEU A 137
ASN A  46
ARG A 168
 None
None
None
FAD  A 699 (-3.9A)
FAD  A 699 ( 4.3A)
 1.33A 3kp6B-1fcdA:
0.0		 3kp6B-1fcdA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 THR A 121
ALA A 122
LEU A 124
ALA A 126
SER A 127
 THR  A 121 ( 0.8A)
ALA  A 122 ( 0.0A)
LEU  A 124 ( 0.6A)
ALA  A 126 ( 0.0A)
SER  A 127 ( 0.0A)
 1.50A 3kp6B-1gc7A:
0.0		 3kp6B-1gc7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ih5 AQUAPORIN-1

(Homo sapiens) 		PF00230
(MIP) 		5 THR A 109
ALA A 110
LEU A 112
ASN A 127
ARG A 126
 None
 1.42A 3kp6B-1ih5A:
0.0		 3kp6B-1ih5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		5 THR A 149
ALA A 150
LEU A 152
ALA A 154
SER A 155
 None
 1.42A 3kp6B-1n4oA:
0.0		 3kp6B-1n4oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		5 ASN A 189
ALA A 191
GLN A 324
ALA A 302
SER A 303
 None
 1.27A 3kp6B-1ohfA:
undetectable		 3kp6B-1ohfA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0d HUNTINGTIN
INTERACTING PROTEIN
12

(Homo sapiens) 		PF01608
(I_LWEQ) 		5 THR A 914
ALA A 915
LEU A 917
ALA A 919
SER A 921
 None
 1.43A 3kp6B-1r0dA:
1.3		 3kp6B-1r0dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 THR A 207
ALA A 209
LEU A 208
GLN A 167
ALA A 170
 None
 1.46A 3kp6B-1r5aA:
0.0		 3kp6B-1r5aA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 ASN A 168
ALA A 172
LEU A 175
ALA A 188
SER A 125
 None
 1.16A 3kp6B-1u60A:
undetectable		 3kp6B-1u60A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 ASN A 499
THR A 503
ALA A 501
LEU A 504
ALA A 529
 None
 1.46A 3kp6B-1ut9A:
undetectable		 3kp6B-1ut9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 THR A 191
ALA A 192
LEU A 194
ALA A 196
SER A 197
 None
 1.45A 3kp6B-1vgmA:
undetectable		 3kp6B-1vgmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 THR A 236
ALA A 237
LEU A 239
ALA A 241
SER A 243
 None
 1.21A 3kp6B-1vhkA:
undetectable		 3kp6B-1vhkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		5 ASN A 151
THR A 152
ALA A  40
SER A  37
ARG A  33
 None
 1.48A 3kp6B-2bv8A:
1.5		 3kp6B-2bv8A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4z CHLORIDE CHANNEL
PROTEIN

(Torpedo
marmorata) 		no annotation 5 ASN A 580
THR A 581
LEU A 583
ALA A 551
SER A 552
 None
 1.45A 3kp6B-2d4zA:
undetectable		 3kp6B-2d4zA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 THR A  81
ALA A  82
LEU A  84
ALA A  86
SER A  88
 None
 1.24A 3kp6B-2dg7A:
undetectable		 3kp6B-2dg7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 ASN A  75
THR A  78
ALA A  79
LEU A  82
ALA A 126
 DGL  A 501 (-4.0A)
None
None
None
None
 1.11A 3kp6B-2gzmA:
undetectable		 3kp6B-2gzmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		5 ASN A  73
THR A  76
ALA A  77
LEU A  80
ALA A 124
 DGL  A1267 (-4.3A)
None
None
None
None
 1.22A 3kp6B-2jfqA:
undetectable		 3kp6B-2jfqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzd DARPIN-3.4

(synthetic
construct) 		PF12796
(Ank_2) 		5 ASN G 123
THR G  89
ALA G  88
LEU G  86
ALA G 116
 None
 1.48A 3kp6B-2xzdG:
undetectable		 3kp6B-2xzdG:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cah AGGLUTININ II

(Sambucus nigra) 		PF00652
(Ricin_B_lectin) 		5 ASN A  78
LEU A  97
ALA A  58
SER A  65
ASN A  62
 None
 1.26A 3kp6B-3cahA:
undetectable		 3kp6B-3cahA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		5 THR A 272
ALA A 275
LEU A 274
ALA A 246
ASN A  75
 None
 1.47A 3kp6B-3gybA:
undetectable		 3kp6B-3gybA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyk 27KDA OUTER MEMBRANE
PROTEIN

(Ruegeria
pomeroyi) 		PF13462
(Thioredoxin_4) 		5 ALA A 132
LEU A 133
GLN A 129
SER A   4
ASN A   1
 None
 1.44A 3kp6B-3gykA:
undetectable		 3kp6B-3gykA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN ALPHA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		5 ASN A 151
THR A 152
ALA A  40
SER A  37
ARG A  33
 None
None
None
None
BLA  B 555 (-3.4A)
 1.49A 3kp6B-3kvsA:
1.6		 3kp6B-3kvsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 THR A 203
ALA A 202
LEU A 200
ALA A 198
ASN A 214
 None
 1.29A 3kp6B-3l7gA:
0.6		 3kp6B-3l7gA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr7 USPA1

(Moraxella
catarrhalis) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 ASN A 272
THR A 273
ALA A 274
LEU A 268
ASN A 241
 None
 1.45A 3kp6B-3pr7A:
undetectable		 3kp6B-3pr7A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 THR A  44
ALA A  45
LEU A  47
ALA A  49
ARG A  90
 None
 1.27A 3kp6B-3slkA:
undetectable		 3kp6B-3slkA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		5 ALA B 583
LEU B 585
ALA B 587
SER B 589
ARG B 839
 None
 1.27A 3kp6B-3thwB:
undetectable		 3kp6B-3thwB:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		5 THR A  81
ALA A 144
LEU A 143
SER A  63
ARG A  67
 None
 1.34A 3kp6B-4bvxA:
undetectable		 3kp6B-4bvxA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eju TRANSCRIPTIONAL
REGULATOR TCAR

(Staphylococcus
epidermidis) 		PF12802
(MarR_2) 		9 ASN A  20
THR A  23
ALA A  24
LEU A  27
GLN A  31
ALA A  38
SER A  41
ASN A  45
ARG A 110
 None
 0.37A 3kp6B-4ejuA:
19.6		 3kp6B-4ejuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		5 ALA A 117
GLN A 118
ALA A 163
SER A 166
ASN A 170
 None
 1.25A 3kp6B-4fs3A:
undetectable		 3kp6B-4fs3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF00989
(PAS) 		5 ASN C 229
ALA C 233
LEU C 238
ALA C 240
SER C 243
 None
 1.25A 3kp6B-4lryC:
2.2		 3kp6B-4lryC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 ASN A 516
ALA A 517
ALA A 674
SER A 675
ARG A 647
 None
 1.47A 3kp6B-4rbnA:
undetectable		 3kp6B-4rbnA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rou MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		no annotation 5 ALA B 467
GLN B 466
ALA B 434
SER B 431
ASN B 428
 None
 1.49A 3kp6B-4rouB:
undetectable		 3kp6B-4rouB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 THR A 203
ALA A 202
LEU A 200
ALA A 198
ASN A 214
 None
 1.37A 3kp6B-4zwoA:
undetectable		 3kp6B-4zwoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 THR A 266
ALA A 264
LEU A 299
ASN A 303
ARG A 302
 None
 1.34A 3kp6B-5aa6A:
undetectable		 3kp6B-5aa6A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d66 UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF12796
(Ank_2) 		5 ASN A  85
THR A  82
ALA A  81
LEU A  78
ALA A  89
 CL  A 302 ( 4.1A)
None
None
None
None
 1.13A 3kp6B-5d66A:
undetectable		 3kp6B-5d66A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 THR B 287
ALA B 288
LEU B 290
ALA B 292
SER B 293
 None
 1.36A 3kp6B-5grhB:
undetectable		 3kp6B-5grhB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsz NUCLEOID OCCLUSION
FACTOR SLMA

(Klebsiella
pneumoniae) 		PF00440
(TetR_N) 		5 THR A  34
ALA A  35
LEU A  37
ALA A  39
SER A  40
 None
 1.36A 3kp6B-5hszA:
1.2		 3kp6B-5hszA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A  88
LEU A  94
GLN A  91
ALA A 123
SER A 119
 None
 1.38A 3kp6B-5j04A:
undetectable		 3kp6B-5j04A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 275
LEU A 276
GLN A 218
ASN A 223
ARG A 385
 None
 1.22A 3kp6B-5jp0A:
undetectable		 3kp6B-5jp0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 ALA B2089
LEU B2096
ALA B2061
SER B2063
ARG B2159
 None
 1.07A 3kp6B-5k8dB:
undetectable		 3kp6B-5k8dB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm7 PEPTIDOGLYCAN-BINDIN
G DOMAIN 1

(Burkholderia) 		no annotation 5 THR G 176
ALA G 175
LEU G 173
ALA G 164
SER G 165
 None
None
PGE  G 304 (-4.8A)
None
None
 1.23A 3kp6B-5nm7G:
undetectable		 3kp6B-5nm7G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		5 THR A 407
ALA A 406
LEU A 404
ALA A 402
ASN A 370
 None
 1.34A 3kp6B-5u4oA:
undetectable		 3kp6B-5u4oA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5s OUTER MEMBRANE
PROTEIN TOLC

(Escherichia
coli) 		PF02321
(OEP) 		5 THR A 111
ALA A 110
LEU A 107
SER A 402
ASN A 399
 None
 1.19A 3kp6B-5v5sA:
0.6		 3kp6B-5v5sA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 5 THR A 529
ALA A 530
LEU A 532
ALA A 534
SER A 536
 None
 1.13A 3kp6B-5x3jA:
undetectable		 3kp6B-5x3jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 5 ASN A 363
THR A 360
ALA A 361
ALA A 394
SER A 390
 None
 1.28A 3kp6B-5xj1A:
undetectable		 3kp6B-5xj1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2

(Arabidopsis
thaliana) 		no annotation 5 ASN A 410
THR A 139
ALA A 136
LEU A 148
ARG A 150
 NAG  A 501 (-4.2A)
None
None
None
None
 1.36A 3kp6B-5y92A:
undetectable		 3kp6B-5y92A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S5

(Leishmania
donovani) 		no annotation 5 THR F 226
ALA F 225
LEU F 222
ALA F 178
SER F 212
 None
None
None
None
C  1   4 ( 3.7A)
 1.33A 3kp6B-6az1F:
undetectable		 3kp6B-6az1F:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvd LIGHT CHAIN

(Clostridium
botulinum) 		no annotation 5 THR A 306
ALA A 307
GLN A 148
SER A 136
ASN A 132
 None
 1.38A 3kp6B-6bvdA:
0.4		 3kp6B-6bvdA:
17.76