SIMILAR PATTERNS OF AMINO ACIDS FOR 3KP6_B_SALB3006

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bd2 T CELL RECEPTOR
ALPHA


(Homo sapiens)
PF07686
(V-set)
PF09291
(DUF1968)
4 ASN D 117
ILE D 118
GLU D  14
ASN D 115
None
1.37A 3kp6A-1bd2D:
undetectable
3kp6B-1bd2D:
0.0
3kp6A-1bd2D:
21.46
3kp6B-1bd2D:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE


(Salmonella
enterica)
PF00291
(PALP)
4 ASN A  47
MET A  48
GLU A 150
ASN A 148
None
1.38A 3kp6A-1d6sA:
0.0
3kp6B-1d6sA:
0.0
3kp6A-1d6sA:
19.88
3kp6B-1d6sA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0y INTERLEUKIN-1
RECEPTOR, TYPE I


(Homo sapiens)
PF07679
(I-set)
PF13895
(Ig_2)
4 ILE R  14
GLU R  11
LYS R  12
ASN R 216
None
1.40A 3kp6A-1g0yR:
undetectable
3kp6B-1g0yR:
0.0
3kp6A-1g0yR:
19.87
3kp6B-1g0yR:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hml ALPHA-LACTALBUMIN

(Homo sapiens)
PF00062
(Lys)
4 ASN A  44
GLU A  49
LYS A  58
ASN A  57
None
ZN  A 125 ( 2.1A)
None
None
1.43A 3kp6A-1hmlA:
undetectable
3kp6B-1hmlA:
0.4
3kp6A-1hmlA:
25.86
3kp6B-1hmlA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4)
PF03104
(DNA_pol_B_exo1)
4 ASN A  23
ILE A  20
GLU A  22
LYS A   2
None
1.32A 3kp6A-1nozA:
0.3
3kp6B-1nozA:
0.0
3kp6A-1nozA:
16.84
3kp6B-1nozA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE


(Plasmodium
falciparum)
PF00709
(Adenylsucc_synt)
4 ASN A 217
ILE A 262
GLU A 221
ASN A 219
None
1.05A 3kp6A-1p9bA:
0.0
3kp6B-1p9bA:
0.0
3kp6A-1p9bA:
15.87
3kp6B-1p9bA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvh INTERLEUKIN-6
RECEPTOR BETA CHAIN


(Homo sapiens)
PF00041
(fn3)
PF09240
(IL6Ra-bind)
4 ASN A 201
GLU A 116
LYS A 199
ASN A 115
None
1.46A 3kp6A-1pvhA:
undetectable
3kp6B-1pvhA:
0.0
3kp6A-1pvhA:
22.48
3kp6B-1pvhA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE


(Thermotoga
maritima)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 ASN A 248
ILE A  93
GLU A 251
ASN A 246
None
1.36A 3kp6A-1wopA:
0.0
3kp6B-1wopA:
0.0
3kp6A-1wopA:
17.81
3kp6B-1wopA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Escherichia
coli)
PF02540
(NAD_synthase)
4 ASN A 188
ILE A  17
GLU A 239
LYS A  14
None
1.48A 3kp6A-1wxfA:
0.0
3kp6B-1wxfA:
0.0
3kp6A-1wxfA:
22.94
3kp6B-1wxfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00132
(Hexapep)
4 ILE A  26
GLU A   5
LYS A   9
ASN A   7
None
1.49A 3kp6A-2fkoA:
undetectable
3kp6B-2fkoA:
undetectable
3kp6A-2fkoA:
23.81
3kp6B-2fkoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES


(Escherichia
coli)
PF07995
(GSDH)
4 ASN A 222
ILE A 193
GLU A 220
ASN A 211
CA  A2002 ( 4.4A)
None
CA  A2002 (-2.2A)
None
1.15A 3kp6A-2g8sA:
undetectable
3kp6B-2g8sA:
undetectable
3kp6A-2g8sA:
18.80
3kp6B-2g8sA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR


(Saccharomyces
cerevisiae)
PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16)
4 ASN A 210
GLU A 177
LYS A 181
ASN A 176
None
1.47A 3kp6A-2gw1A:
0.0
3kp6B-2gw1A:
undetectable
3kp6A-2gw1A:
16.96
3kp6B-2gw1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus)
PF05791
(Bacillus_HBL)
4 ASN A 260
ILE A 153
GLU A 261
ASN A 258
None
1.33A 3kp6A-2nrjA:
0.9
3kp6B-2nrjA:
0.5
3kp6A-2nrjA:
19.58
3kp6B-2nrjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE


(Lactococcus
lactis)
PF00232
(Glyco_hydro_1)
4 ASN A 297
ILE A 296
GLU A 375
ASN A 376
None
1.38A 3kp6A-2pbgA:
0.0
3kp6B-2pbgA:
undetectable
3kp6A-2pbgA:
16.02
3kp6B-2pbgA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster)
PF00795
(CN_hydrolase)
4 ASN A 187
MET A 161
ILE A 115
GLU A 225
None
1.46A 3kp6A-2vhhA:
undetectable
3kp6B-2vhhA:
undetectable
3kp6A-2vhhA:
15.66
3kp6B-2vhhA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vim THIOREDOXIN

(Fasciola
hepatica)
PF00085
(Thioredoxin)
4 ASN A  17
ILE A  22
GLU A  16
ASN A  15
None
1.38A 3kp6A-2vimA:
undetectable
3kp6B-2vimA:
undetectable
3kp6A-2vimA:
21.05
3kp6B-2vimA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE


(unidentified)
PF01979
(Amidohydro_1)
4 ASN A 379
ILE A 380
GLU A 374
ASN A 375
None
1.34A 3kp6A-3be7A:
0.0
3kp6B-3be7A:
undetectable
3kp6A-3be7A:
21.29
3kp6B-3be7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Bacillus
anthracis)
PF02350
(Epimerase_2)
4 ASN A 220
MET A 221
ILE A 328
ASN A 213
None
1.43A 3kp6A-3beoA:
undetectable
3kp6B-3beoA:
undetectable
3kp6A-3beoA:
17.66
3kp6B-3beoA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE


(Homo sapiens)
PF03403
(PAF-AH_p_II)
4 ASN A 421
ILE A 422
GLU A 320
ASN A 318
None
1.13A 3kp6A-3d5eA:
undetectable
3kp6B-3d5eA:
undetectable
3kp6A-3d5eA:
18.23
3kp6B-3d5eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exs RMPD
(HEXULOSE-6-PHOSPHAT
E SYNTHASE)


(Streptococcus
mutans)
PF00215
(OMPdecase)
4 ILE A  60
GLU A 113
LYS A 111
ASN A 108
None
1.40A 3kp6A-3exsA:
undetectable
3kp6B-3exsA:
undetectable
3kp6A-3exsA:
23.01
3kp6B-3exsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1c PUTATIVE
2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
2


(Listeria
monocytogenes)
PF01128
(IspD)
4 ASN A  43
ILE A   2
GLU A 122
ASN A 124
None
1.02A 3kp6A-3f1cA:
undetectable
3kp6B-3f1cA:
undetectable
3kp6A-3f1cA:
22.13
3kp6B-3f1cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN


(Bacillus virus
phi29)
PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3)
4 ASN A 189
ILE A 190
GLU A 188
ASN A 266
None
1.16A 3kp6A-3gq9A:
undetectable
3kp6B-3gq9A:
undetectable
3kp6A-3gq9A:
13.49
3kp6B-3gq9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmq NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Salmonella
enterica)
PF02540
(NAD_synthase)
4 ASN A 188
ILE A  17
GLU A 239
LYS A  14
None
1.39A 3kp6A-3hmqA:
undetectable
3kp6B-3hmqA:
undetectable
3kp6A-3hmqA:
20.28
3kp6B-3hmqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6o UNCHARACTERIZED
PROTEIN DUF1344


(Bacteroides
vulgatus)
PF12667
(NigD_N)
PF17415
(NigD_C)
4 ASN A 114
ILE A 121
GLU A 160
ASN A 159
None
None
PG4  A   1 (-3.2A)
None
1.19A 3kp6A-3k6oA:
undetectable
3kp6B-3k6oA:
undetectable
3kp6A-3k6oA:
21.03
3kp6B-3k6oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6o UNCHARACTERIZED
PROTEIN DUF1344


(Bacteroides
vulgatus)
PF12667
(NigD_N)
PF17415
(NigD_C)
4 MET A 118
ILE A 121
GLU A 160
ASN A 159
None
None
PG4  A   1 (-3.2A)
None
1.15A 3kp6A-3k6oA:
undetectable
3kp6B-3k6oA:
undetectable
3kp6A-3k6oA:
21.03
3kp6B-3k6oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE


(Streptococcus
agalactiae)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 ASN A 297
ILE A 287
GLU A 264
ASN A 265
SO4  A 453 (-3.5A)
None
None
None
0.76A 3kp6A-3lk7A:
undetectable
3kp6B-3lk7A:
undetectable
3kp6A-3lk7A:
15.93
3kp6B-3lk7A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)


(Aquifex
aeolicus)
PF00158
(Sigma54_activat)
4 ASN A 355
ILE A 307
GLU A 168
ASN A 280
None
None
None
ATP  A 400 (-4.2A)
1.32A 3kp6A-3m0eA:
undetectable
3kp6B-3m0eA:
undetectable
3kp6A-3m0eA:
22.51
3kp6B-3m0eA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Shigella
flexneri)
PF00145
(DNA_methylase)
4 ASN A  43
ILE A  49
GLU A  67
ASN A  38
None
1.32A 3kp6A-3me5A:
undetectable
3kp6B-3me5A:
undetectable
3kp6A-3me5A:
18.58
3kp6B-3me5A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
4 MET A  64
ILE A  66
GLU A  62
ASN A  14
None
1.40A 3kp6A-3otmA:
undetectable
3kp6B-3otmA:
undetectable
3kp6A-3otmA:
20.00
3kp6B-3otmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qor NUCLEAR MIGRATION
PROTEIN NUDC


(Homo sapiens)
PF04969
(CS)
4 ASN A 224
ILE A 248
GLU A 252
LYS A 250
None
ACT  A 301 ( 4.5A)
None
None
1.13A 3kp6A-3qorA:
undetectable
3kp6B-3qorA:
undetectable
3kp6A-3qorA:
23.42
3kp6B-3qorA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skp SEROTRANSFERRIN

(Homo sapiens)
PF00405
(Transferrin)
4 ASN A 383
MET A 382
ILE A 381
GLU A 385
None
1.48A 3kp6A-3skpA:
0.9
3kp6B-3skpA:
undetectable
3kp6A-3skpA:
17.66
3kp6B-3skpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis)
PF00232
(Glyco_hydro_1)
4 ASN A 202
MET A 201
ILE A 199
GLU A 203
None
1.22A 3kp6A-3wq4A:
undetectable
3kp6B-3wq4A:
undetectable
3kp6A-3wq4A:
14.65
3kp6B-3wq4A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
4 ASN A 399
MET A 405
ILE A 400
ASN A 417
None
1.46A 3kp6A-3zuqA:
2.1
3kp6B-3zuqA:
1.5
3kp6A-3zuqA:
11.26
3kp6B-3zuqA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis)
PF00089
(Trypsin)
PF14670
(FXa_inhibition)
4 ASN A  95
ILE A 107
LYS A  89
ASN A  93
None
1.42A 3kp6A-4bxwA:
undetectable
3kp6B-4bxwA:
undetectable
3kp6A-4bxwA:
16.16
3kp6B-4bxwA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1


(Saccharomyces
cerevisiae)
PF09770
(PAT1)
4 ASN H 687
MET H 691
ILE H 690
GLU H 701
None
None
None
CO  H1080 (-3.8A)
1.26A 3kp6A-4c8qH:
undetectable
3kp6B-4c8qH:
undetectable
3kp6A-4c8qH:
19.21
3kp6B-4c8qH:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE


(Streptococcus
mutans)
PF01063
(Aminotran_4)
4 ASN A  76
ILE A 100
GLU A  80
ASN A  78
None
1.34A 3kp6A-4dqnA:
undetectable
3kp6B-4dqnA:
undetectable
3kp6A-4dqnA:
18.55
3kp6B-4dqnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1


(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
no annotation
4 ASN A 807
ILE A 804
GLU A 809
LYS B 507
None
1.20A 3kp6A-4fddA:
1.4
3kp6B-4fddA:
undetectable
3kp6A-4fddA:
10.71
3kp6B-4fddA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE


(Bacteroides
uniformis)
PF10091
(Glycoamylase)
4 ASN A 131
MET A 130
ILE A 138
GLU A  75
None
1.27A 3kp6A-4gl3A:
undetectable
3kp6B-4gl3A:
undetectable
3kp6A-4gl3A:
17.00
3kp6B-4gl3A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkx HEMAGGLUTININ HA1

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 ASN E 150
ILE E  65
GLU E  72
ASN E  68
None
None
None
NAG  E 301 (-3.5A)
1.35A 3kp6A-4hkxE:
undetectable
3kp6B-4hkxE:
undetectable
3kp6A-4hkxE:
21.15
3kp6B-4hkxE:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)


(Aquifex
aeolicus)
PF00072
(Response_reg)
PF00158
(Sigma54_activat)
4 ASN A 355
ILE A 307
GLU A 168
ASN A 280
None
1.24A 3kp6A-4l4uA:
undetectable
3kp6B-4l4uA:
undetectable
3kp6A-4l4uA:
19.06
3kp6B-4l4uA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb8 URICASE

(unclassified
Mammalia)
PF01014
(Uricase)
4 ILE A 276
GLU A 280
LYS A 278
ASN A 267
None
1.44A 3kp6A-4mb8A:
undetectable
3kp6B-4mb8A:
undetectable
3kp6A-4mb8A:
19.87
3kp6B-4mb8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN


(Vibrio cholerae)
PF00165
(HTH_AraC)
4 ILE A 104
GLU A 156
LYS A 157
ASN A 160
None
1.07A 3kp6A-4mloA:
2.6
3kp6B-4mloA:
2.6
3kp6A-4mloA:
23.22
3kp6B-4mloA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1


(Saccharomyces
cerevisiae)
no annotation 4 ASN A 339
MET A 313
GLU A 335
LYS A 333
None
1.23A 3kp6A-4n5cA:
undetectable
3kp6B-4n5cA:
undetectable
3kp6A-4n5cA:
10.47
3kp6B-4n5cA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN


(Dictyostelium
discoideum)
no annotation 4 ILE A 276
GLU A 179
LYS A 271
ASN A  51
None
1.46A 3kp6A-4x3nA:
1.3
3kp6B-4x3nA:
0.5
3kp6A-4x3nA:
20.39
3kp6B-4x3nA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN


(Influenza C
virus)
PF00603
(Flu_PA)
4 MET A 387
ILE A 390
GLU A 385
ASN A 383
None
1.12A 3kp6A-5d9aA:
1.8
3kp6B-5d9aA:
2.5
3kp6A-5d9aA:
13.93
3kp6B-5d9aA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT


(Influenza C
virus)
PF00602
(Flu_PB1)
PF00603
(Flu_PA)
4 ILE A 350
GLU B 367
LYS B 366
ASN B 361
None
1.40A 3kp6A-5d9aA:
1.8
3kp6B-5d9aA:
2.5
3kp6A-5d9aA:
13.93
3kp6B-5d9aA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1


(Rickettsia
prowazekii)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
4 ASN A 114
ILE A  87
GLU A 110
ASN A 112
None
1.33A 3kp6A-5dpdA:
undetectable
3kp6B-5dpdA:
undetectable
3kp6A-5dpdA:
15.49
3kp6B-5dpdA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI


(Lactococcus
lactis)
PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
4 ASN A 761
ILE A 945
GLU A 984
ASN A 759
None
1.16A 3kp6A-5ffjA:
undetectable
3kp6B-5ffjA:
undetectable
3kp6A-5ffjA:
7.39
3kp6B-5ffjA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata)
no annotation 4 ASN A 357
MET A 354
ILE A 358
ASN A 327
None
1.38A 3kp6A-5h2tA:
undetectable
3kp6B-5h2tA:
undetectable
3kp6A-5h2tA:
12.81
3kp6B-5h2tA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Streptococcus
porcinus)
PF01791
(DeoC)
4 MET A 190
ILE A 163
GLU A 188
ASN A 187
None
1.47A 3kp6A-5hjlA:
undetectable
3kp6B-5hjlA:
0.3
3kp6A-5hjlA:
20.43
3kp6B-5hjlA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huj NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Streptococcus
pyogenes)
PF02540
(NAD_synthase)
4 ASN A 196
ILE A  25
GLU A 247
LYS A  22
None
1.31A 3kp6A-5hujA:
undetectable
3kp6B-5hujA:
undetectable
3kp6A-5hujA:
20.07
3kp6B-5hujA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izt OUTER SURFACE
PROTEIN


(Borreliella
burgdorferi)
PF05714
(Borrelia_lipo_1)
4 ILE A 323
GLU A 201
LYS A 199
ASN A 200
None
1.48A 3kp6A-5iztA:
1.7
3kp6B-5iztA:
1.5
3kp6A-5iztA:
18.34
3kp6B-5iztA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6w STAPHYLOCOCCAL
COMPLEMENT INHIBITOR


(Staphylococcus
aureus)
PF11546
(CompInhib_SCIN)
4 ASN N  29
ILE N  44
GLU N  25
ASN N  27
None
1.24A 3kp6A-5m6wN:
1.8
3kp6B-5m6wN:
2.1
3kp6A-5m6wN:
21.85
3kp6B-5m6wN:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF00012
(HSP70)
4 ASN A 454
ILE A 414
GLU A 456
ASN A 458
None
1.38A 3kp6A-5tkyA:
0.3
3kp6B-5tkyA:
undetectable
3kp6A-5tkyA:
14.29
3kp6B-5tkyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE


(Enterococcus
faecalis)
no annotation 4 ILE A  15
GLU A 213
LYS A 214
ASN A 211
None
1.43A 3kp6A-5v2mA:
undetectable
3kp6B-5v2mA:
undetectable
3kp6A-5v2mA:
17.77
3kp6B-5v2mA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp0 NH(3)-DEPENDENT
NAD(+) SYNTHETASE


(Aliivibrio
fischeri)
PF02540
(NAD_synthase)
4 ASN A 194
ILE A  15
GLU A 245
LYS A  12
None
1.34A 3kp6A-5wp0A:
undetectable
3kp6B-5wp0A:
undetectable
3kp6A-5wp0A:
19.78
3kp6B-5wp0A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB HEAVY
CHAIN


(Mus musculus)
no annotation 4 ASN A  35
MET A  34
ILE A  51
ASN A  96
None
1.18A 3kp6A-6c08A:
undetectable
3kp6B-6c08A:
undetectable
3kp6A-6c08A:
19.74
3kp6B-6c08A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE


(Acetobacterium
woodii)
no annotation 4 ASN A 365
GLU A 364
LYS A 362
ASN A 361
None
None
FAD  A 401 (-4.7A)
FAD  A 401 (-2.9A)
1.40A 3kp6A-6fahA:
undetectable
3kp6B-6fahA:
undetectable
3kp6A-6fahA:
16.88
3kp6B-6fahA:
16.88