SIMILAR PATTERNS OF AMINO ACIDS FOR 3KP6_B_SALB3003_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus)
PF00079
(Serpin)
4 ILE A 413
VAL A 411
LEU A 284
LEU A 273
None
0.78A 3kp6A-1attA:
0.0
3kp6B-1attA:
0.0
3kp6A-1attA:
16.08
3kp6B-1attA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
4 ILE A 352
VAL A 351
LEU A 275
LEU A 273
None
0.92A 3kp6A-1dcnA:
0.0
3kp6B-1dcnA:
0.0
3kp6A-1dcnA:
17.70
3kp6B-1dcnA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE


(Escherichia
coli)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 ILE A  18
VAL A  20
LEU A  75
LEU A  62
None
0.89A 3kp6A-1gytA:
0.3
3kp6B-1gytA:
0.0
3kp6A-1gytA:
15.34
3kp6B-1gytA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum)
PF00977
(His_biosynth)
4 ILE A 237
VAL A 240
LEU A 244
LEU A   5
None
0.78A 3kp6A-1h5yA:
undetectable
3kp6B-1h5yA:
undetectable
3kp6A-1h5yA:
21.57
3kp6B-1h5yA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae)
PF02367
(TsaE)
4 ILE A 127
VAL A 129
LEU A  38
LEU A 111
None
0.81A 3kp6A-1htwA:
0.0
3kp6B-1htwA:
undetectable
3kp6A-1htwA:
26.86
3kp6B-1htwA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1


(Homo sapiens)
PF00415
(RCC1)
4 VAL B 404
LEU B 413
HIS B 410
LEU B  40
None
0.67A 3kp6A-1i2mB:
undetectable
3kp6B-1i2mB:
0.0
3kp6A-1i2mB:
16.96
3kp6B-1i2mB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803)
PF00497
(SBP_bac_3)
4 ILE A 183
VAL A 185
ARG A 163
LEU A 166
None
0.83A 3kp6A-1iiwA:
undetectable
3kp6B-1iiwA:
undetectable
3kp6A-1iiwA:
20.80
3kp6B-1iiwA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN


(Acidianus
ambivalens)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 ILE F  73
VAL F  76
LEU F  80
HIS F 294
None
0.80A 3kp6A-1j8mF:
0.0
3kp6B-1j8mF:
0.1
3kp6A-1j8mF:
19.87
3kp6B-1j8mF:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 ILE A 382
VAL A  49
LEU A 392
LEU A 428
None
0.72A 3kp6A-1nfgA:
0.0
3kp6B-1nfgA:
undetectable
3kp6A-1nfgA:
17.94
3kp6B-1nfgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsl PROBABLE
ACETYLTRANSFERASE


(Bacillus
subtilis)
PF13302
(Acetyltransf_3)
4 ILE A  96
VAL A 130
HIS A  85
LEU A  87
None
0.61A 3kp6A-1nslA:
undetectable
3kp6B-1nslA:
undetectable
3kp6A-1nslA:
25.76
3kp6B-1nslA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum)
PF01425
(Amidase)
4 ILE A  61
VAL A  59
LEU A 146
LEU A 192
None
0.85A 3kp6A-1ocmA:
undetectable
3kp6B-1ocmA:
undetectable
3kp6A-1ocmA:
15.00
3kp6B-1ocmA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE


(Enterobacter
cloacae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ILE A 526
VAL A 528
LEU A 460
LEU A 432
None
0.67A 3kp6A-1ovmA:
0.0
3kp6B-1ovmA:
undetectable
3kp6A-1ovmA:
14.75
3kp6B-1ovmA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)


(Ascophyllum
nodosum)
no annotation 4 ILE A 386
VAL A 383
ARG A 382
LEU A 379
None
0.64A 3kp6A-1qi9A:
0.5
3kp6B-1qi9A:
0.3
3kp6A-1qi9A:
15.23
3kp6B-1qi9A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw1 DIPHTHERIA TOXIN
REPRESSOR


(Corynebacterium
diphtheriae)
no annotation 4 ILE A 223
VAL A 152
ARG A 151
LEU A 138
None
0.93A 3kp6A-1qw1A:
undetectable
3kp6B-1qw1A:
undetectable
3kp6A-1qw1A:
24.52
3kp6B-1qw1A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A


(Homo sapiens)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
4 ILE A 407
VAL A 413
LEU A 415
LEU A 403
None
0.89A 3kp6A-1r47A:
undetectable
3kp6B-1r47A:
undetectable
3kp6A-1r47A:
17.51
3kp6B-1r47A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2


(Homo sapiens)
PF00595
(PDZ)
4 ILE A  52
VAL A  49
LEU A  33
LEU A  90
None
0.84A 3kp6A-1x5rA:
undetectable
3kp6B-1x5rA:
undetectable
3kp6A-1x5rA:
23.75
3kp6B-1x5rA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE


(Rattus
norvegicus)
PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C)
4 ILE A  66
VAL A 191
LEU A 193
LEU A  86
None
0.73A 3kp6A-1yjkA:
undetectable
3kp6B-1yjkA:
undetectable
3kp6A-1yjkA:
20.22
3kp6B-1yjkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens)
PF00079
(Serpin)
4 ILE I 412
VAL I 410
LEU I 283
LEU I 272
None
0.89A 3kp6A-2b4xI:
0.4
3kp6B-2b4xI:
undetectable
3kp6A-2b4xI:
20.57
3kp6B-2b4xI:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR


(Homo sapiens)
PF13516
(LRR_6)
4 ILE A 181
VAL A 176
LEU A 148
LEU A 129
None
0.87A 3kp6A-2bexA:
undetectable
3kp6B-2bexA:
undetectable
3kp6A-2bexA:
15.32
3kp6B-2bexA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 ILE A 250
VAL A   6
LEU A  38
LEU A  28
None
0.92A 3kp6A-2c4nA:
undetectable
3kp6B-2c4nA:
undetectable
3kp6A-2c4nA:
21.86
3kp6B-2c4nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy4 EPIDERMAL GROWTH
FACTOR RECEPTOR
PATHWAY SUBSTRATE
8-LIKE PROTEIN 1


(Mus musculus)
PF08416
(PTB)
4 VAL A  85
LEU A  78
HIS A 135
LEU A 120
None
0.88A 3kp6A-2cy4A:
undetectable
3kp6B-2cy4A:
undetectable
3kp6A-2cy4A:
22.99
3kp6B-2cy4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR


(Escherichia
coli)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF)
4 ILE A  45
VAL A  43
LEU A 106
LEU A  70
None
0.86A 3kp6A-2eyqA:
undetectable
3kp6B-2eyqA:
undetectable
3kp6A-2eyqA:
9.37
3kp6B-2eyqA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA


(Salmonella
enterica)
PF09052
(SipA)
4 ILE C 187
VAL C 183
LEU C 155
LEU C 152
None
0.93A 3kp6A-2fm8C:
undetectable
3kp6B-2fm8C:
undetectable
3kp6A-2fm8C:
23.50
3kp6B-2fm8C:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvz INOSITOL
MONOPHOSPHATASE 2


(Homo sapiens)
PF00459
(Inositol_P)
4 ILE A 120
VAL A 132
LEU A 141
LEU A  28
None
0.81A 3kp6A-2fvzA:
undetectable
3kp6B-2fvzA:
undetectable
3kp6A-2fvzA:
22.11
3kp6B-2fvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK


(Escherichia
coli)
PF01041
(DegT_DnrJ_EryC1)
4 ILE A 328
VAL A 369
LEU A 367
LEU A 319
None
0.87A 3kp6A-2gmuA:
undetectable
3kp6B-2gmuA:
undetectable
3kp6A-2gmuA:
18.18
3kp6B-2gmuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hm2 PYRIN-ONLY PROTEIN 1

(Homo sapiens)
PF02758
(PYRIN)
4 VAL Q  72
ARG Q  74
LEU Q  73
LEU Q  85
None
0.76A 3kp6A-2hm2Q:
undetectable
3kp6B-2hm2Q:
undetectable
3kp6A-2hm2Q:
21.85
3kp6B-2hm2Q:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2


(Mus musculus)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 ILE A 221
VAL A 200
LEU A   7
HIS A 253
None
0.88A 3kp6A-2ho4A:
undetectable
3kp6B-2ho4A:
undetectable
3kp6A-2ho4A:
20.00
3kp6B-2ho4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)


(Homo sapiens)
PF00328
(His_Phos_2)
4 ILE A1332
VAL A1328
LEU A1268
LEU A1264
None
0.87A 3kp6A-2hpaA:
0.5
3kp6B-2hpaA:
undetectable
3kp6A-2hpaA:
15.27
3kp6B-2hpaA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE


(Drosophila
melanogaster)
PF01712
(dNK)
4 ILE A  25
VAL A  23
LEU A 149
LEU A 203
None
0.91A 3kp6A-2jcsA:
undetectable
3kp6B-2jcsA:
undetectable
3kp6A-2jcsA:
23.48
3kp6B-2jcsA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3f PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YBBH


(Bacillus
subtilis)
PF01418
(HTH_6)
4 VAL A  72
ARG A  71
LEU A  68
LEU A  60
MLY  A  69 ( 4.0A)
None
MLY  A  69 ( 3.6A)
None
0.80A 3kp6A-2o3fA:
1.4
3kp6B-2o3fA:
1.8
3kp6A-2o3fA:
23.65
3kp6B-2o3fA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ool SENSOR PROTEIN

(Rhodopseudomonas
palustris)
PF01590
(GAF)
PF08446
(PAS_2)
4 ILE A 128
VAL A  47
LEU A  45
LEU A 257
None
0.89A 3kp6A-2oolA:
undetectable
3kp6B-2oolA:
undetectable
3kp6A-2oolA:
17.72
3kp6B-2oolA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q78 UNCHARACTERIZED
PROTEIN


(Thermotoga
maritima)
no annotation 4 ILE A 118
VAL A  96
ARG A 116
LEU A  52
None
None
MLC  A 200 ( 4.1A)
None
0.79A 3kp6A-2q78A:
undetectable
3kp6B-2q78A:
undetectable
3kp6A-2q78A:
24.26
3kp6B-2q78A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY


(Vibrio
parahaemolyticus)
PF03466
(LysR_substrate)
4 ILE A  49
VAL A  47
LEU A  18
LEU A  65
None
0.83A 3kp6A-2qsxA:
undetectable
3kp6B-2qsxA:
undetectable
3kp6A-2qsxA:
18.26
3kp6B-2qsxA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE


(Candida
albicans)
PF00926
(DHBP_synthase)
4 ILE A 129
VAL A  60
LEU A  62
LEU A  70
None
0.72A 3kp6A-2riuA:
undetectable
3kp6B-2riuA:
undetectable
3kp6A-2riuA:
19.42
3kp6B-2riuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2


(Arabidopsis
thaliana)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 ILE A 247
VAL A  19
LEU A  16
LEU A  12
None
0.92A 3kp6A-2zvwA:
undetectable
3kp6B-2zvwA:
undetectable
3kp6A-2zvwA:
19.71
3kp6B-2zvwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori)
PF07804
(HipA_C)
4 ILE A 283
ARG A 278
LEU A 275
LEU A 151
None
0.79A 3kp6A-3akkA:
undetectable
3kp6B-3akkA:
undetectable
3kp6A-3akkA:
20.73
3kp6B-3akkA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346


(Corynebacterium
diphtheriae)
PF08903
(DUF1846)
4 ILE A  70
VAL A  68
LEU A 173
LEU A  33
None
0.70A 3kp6A-3bh1A:
undetectable
3kp6B-3bh1A:
undetectable
3kp6A-3bh1A:
17.17
3kp6B-3bh1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum)
PF08477
(Roc)
PF16095
(COR)
4 ILE A 565
VAL A 567
LEU A 539
LEU A 457
None
0.66A 3kp6A-3dpuA:
undetectable
3kp6B-3dpuA:
4.8
3kp6A-3dpuA:
16.21
3kp6B-3dpuA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN


(Geobacillus
kaustophilus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
4 ILE A 319
VAL A 304
LEU A 324
LEU A 267
None
0.92A 3kp6A-3f2bA:
undetectable
3kp6B-3f2bA:
undetectable
3kp6A-3f2bA:
10.62
3kp6B-3f2bA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium)
PF12891
(Glyco_hydro_44)
4 ILE A  37
VAL A  39
LEU A 499
LEU A 532
None
0.82A 3kp6A-3fw6A:
undetectable
3kp6B-3fw6A:
undetectable
3kp6A-3fw6A:
14.15
3kp6B-3fw6A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)


(Burkholderia
pseudomallei)
PF16374
(CIF)
4 ILE A 230
VAL A 228
LEU A 173
LEU A 143
None
0.85A 3kp6A-3gqmA:
undetectable
3kp6B-3gqmA:
undetectable
3kp6A-3gqmA:
19.22
3kp6B-3gqmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdv RESPONSE REGULATOR

(Pseudomonas
putida)
PF00072
(Response_reg)
4 ILE A 146
VAL A 182
LEU A 179
LEU A 175
None
0.91A 3kp6A-3hdvA:
undetectable
3kp6B-3hdvA:
undetectable
3kp6A-3hdvA:
21.74
3kp6B-3hdvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans)
PF01979
(Amidohydro_1)
4 ILE A 217
VAL A 248
LEU A 249
LEU A 300
None
0.83A 3kp6A-3hm7A:
undetectable
3kp6B-3hm7A:
undetectable
3kp6A-3hm7A:
17.39
3kp6B-3hm7A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i99 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(Vibrio cholerae)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
4 ILE A  84
VAL A  97
LEU A 192
LEU A 118
None
0.85A 3kp6A-3i99A:
undetectable
3kp6B-3i99A:
undetectable
3kp6A-3i99A:
16.62
3kp6B-3i99A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE


(Rhodopseudomonas
palustris)
PF00501
(AMP-binding)
4 ILE A  80
VAL A  77
LEU A  73
LEU A 147
None
0.91A 3kp6A-3ivrA:
undetectable
3kp6B-3ivrA:
undetectable
3kp6A-3ivrA:
14.57
3kp6B-3ivrA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE


(Cryptosporidium
parvum)
PF00121
(TIM)
4 ILE A 209
ARG A 207
LEU A 206
LEU A 162
None
0.90A 3kp6A-3krsA:
undetectable
3kp6B-3krsA:
undetectable
3kp6A-3krsA:
19.71
3kp6B-3krsA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1


(Homo sapiens)
PF00899
(ThiF)
4 ILE A 272
VAL A 276
LEU A 277
LEU A 287
None
0.86A 3kp6A-3kydA:
undetectable
3kp6B-3kydA:
undetectable
3kp6A-3kydA:
19.83
3kp6B-3kydA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1


(Mycolicibacterium
smegmatis)
PF02682
(CT_C_D)
4 ILE B  42
VAL B  39
LEU B  53
LEU B  14
None
0.76A 3kp6A-3mmlB:
undetectable
3kp6B-3mmlB:
undetectable
3kp6A-3mmlB:
20.87
3kp6B-3mmlB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H


(Human
gammaherpesvirus
4)
no annotation 4 ILE A 599
VAL A 667
LEU A 661
LEU A 620
None
0.93A 3kp6A-3phfA:
undetectable
3kp6B-3phfA:
undetectable
3kp6A-3phfA:
12.34
3kp6B-3phfA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP)
PF00945
(Rhabdo_ncap)
4 ILE A  66
VAL A  69
LEU A 138
LEU A 141
None
0.92A 3kp6A-3pmkA:
undetectable
3kp6B-3pmkA:
undetectable
3kp6A-3pmkA:
18.64
3kp6B-3pmkA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjp PUTATIVE
UNCHARACTERIZED
PROTEIN PH0350


(Pyrococcus
horikoshii)
PF01881
(Cas_Cas6)
4 ILE A 112
VAL A 109
LEU A   7
LEU A  77
None
0.72A 3kp6A-3qjpA:
undetectable
3kp6B-3qjpA:
undetectable
3kp6A-3qjpA:
22.73
3kp6B-3qjpA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy3 THIOESTERASE

(Pseudomonas
aeruginosa)
PF13279
(4HBT_2)
4 VAL A  58
LEU A 112
HIS A 109
LEU A  91
None
0.73A 3kp6A-3qy3A:
undetectable
3kp6B-3qy3A:
undetectable
3kp6A-3qy3A:
18.01
3kp6B-3qy3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6k RESPONSE REGULATOR
RECEIVER


(Chloroflexus
aurantiacus)
PF00072
(Response_reg)
4 ILE A 120
VAL A 117
ARG A 116
LEU A 113
None
0.83A 3kp6A-3t6kA:
undetectable
3kp6B-3t6kA:
undetectable
3kp6A-3t6kA:
22.93
3kp6B-3t6kA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
4 ILE A  34
VAL A  63
ARG A  68
LEU A  66
None
0.82A 3kp6A-3t7cA:
undetectable
3kp6B-3t7cA:
undetectable
3kp6A-3t7cA:
20.33
3kp6B-3t7cA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3


(Deinococcus
radiodurans)
PF00933
(Glyco_hydro_3)
4 ILE A  74
VAL A  44
LEU A  23
LEU A  28
None
0.85A 3kp6A-3tevA:
undetectable
3kp6B-3tevA:
0.7
3kp6A-3tevA:
17.56
3kp6B-3tevA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5


(Caenorhabditis
elegans)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C)
4 ILE A 473
VAL A 471
LEU A 446
LEU A 412
None
0.84A 3kp6A-3ua4A:
undetectable
3kp6B-3ua4A:
undetectable
3kp6A-3ua4A:
13.01
3kp6B-3ua4A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vjz PUTATIVE
UNCHARACTERIZED
PROTEIN


(Neisseria
meningitidis)
PF14300
(DUF4375)
4 ILE A  89
VAL A  92
LEU A  96
LEU A  80
None
0.79A 3kp6A-3vjzA:
undetectable
3kp6B-3vjzA:
undetectable
3kp6A-3vjzA:
24.26
3kp6B-3vjzA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE


(Phanerochaete
chrysosporium)
no annotation 4 ILE A 219
VAL A 217
LEU A 236
LEU A 245
None
0.79A 3kp6A-4a7kA:
undetectable
3kp6B-4a7kA:
undetectable
3kp6A-4a7kA:
11.10
3kp6B-4a7kA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8


(Saccharomyces
cerevisiae)
PF00022
(Actin)
4 ILE A 422
VAL A 425
LEU A 429
LEU A 470
None
0.51A 3kp6A-4am6A:
3.0
3kp6B-4am6A:
undetectable
3kp6A-4am6A:
13.00
3kp6B-4am6A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9c TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN


(Ruminiclostridium
thermocellum)
PF00942
(CBM_3)
4 ILE A 140
VAL A  40
LEU A  37
LEU A  96
None
0.87A 3kp6A-4b9cA:
undetectable
3kp6B-4b9cA:
undetectable
3kp6A-4b9cA:
22.98
3kp6B-4b9cA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE


(Aspergillus
fumigatus)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
4 ILE A 107
VAL A 110
LEU A 114
LEU A  49
None
0.72A 3kp6A-4bjuA:
undetectable
3kp6B-4bjuA:
undetectable
3kp6A-4bjuA:
16.24
3kp6B-4bjuA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 ILE A 438
VAL A 456
LEU A 460
LEU A1622
None
0.62A 3kp6A-4c3hA:
undetectable
3kp6B-4c3hA:
undetectable
3kp6A-4c3hA:
6.93
3kp6B-4c3hA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Bacillus
anthracis)
PF00483
(NTP_transferase)
4 ILE A 105
VAL A 103
LEU A 173
LEU A 132
None
0.81A 3kp6A-4ecmA:
undetectable
3kp6B-4ecmA:
undetectable
3kp6A-4ecmA:
21.88
3kp6B-4ecmA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eju TRANSCRIPTIONAL
REGULATOR TCAR


(Staphylococcus
epidermidis)
PF12802
(MarR_2)
4 ILE A 130
VAL A 133
ARG A 134
LEU A 137
None
0.51A 3kp6A-4ejuA:
18.7
3kp6B-4ejuA:
19.6
3kp6A-4ejuA:
100.00
3kp6B-4ejuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
ovatus)
PF07523
(Big_3)
PF13306
(LRR_5)
4 ILE A 189
VAL A 167
LEU A 147
LEU A 173
None
0.81A 3kp6A-4fdwA:
undetectable
3kp6B-4fdwA:
undetectable
3kp6A-4fdwA:
18.41
3kp6B-4fdwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gct NUCLEOID OCCLUSION
FACTOR SLMA


(Vibrio cholerae)
PF00440
(TetR_N)
4 ILE A  86
VAL A  89
LEU A  93
LEU A 161
None
0.72A 3kp6A-4gctA:
undetectable
3kp6B-4gctA:
1.4
3kp6A-4gctA:
21.13
3kp6B-4gctA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA


(Thermotoga
maritima)
no annotation 4 ILE D1170
VAL D1173
LEU D1177
LEU D1153
None
0.75A 3kp6A-4hluD:
undetectable
3kp6B-4hluD:
undetectable
3kp6A-4hluD:
22.18
3kp6B-4hluD:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis)
PF00161
(RIP)
4 ILE A  25
VAL A  28
ARG A  29
LEU A  32
None
0.93A 3kp6A-4imvA:
undetectable
3kp6B-4imvA:
undetectable
3kp6A-4imvA:
20.21
3kp6B-4imvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila)
no annotation 4 ILE A 304
ARG A 300
LEU A 297
LEU A 148
None
0.84A 3kp6A-4jw1A:
1.3
3kp6B-4jw1A:
undetectable
3kp6A-4jw1A:
15.09
3kp6B-4jw1A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 ILE A3898
VAL A3895
LEU A3947
LEU A3927
None
0.69A 3kp6A-4kc5A:
undetectable
3kp6B-4kc5A:
undetectable
3kp6A-4kc5A:
10.43
3kp6B-4kc5A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila)
PF01734
(Patatin)
4 ILE A 233
LEU A 224
HIS A 133
LEU A 134
None
0.93A 3kp6A-4kyiA:
undetectable
3kp6B-4kyiA:
undetectable
3kp6A-4kyiA:
14.92
3kp6B-4kyiA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkb HYPOTHETICAL PROTEIN
ALR4568/PUTATIVE
4-OXALOCROTONATE
TAUTOMERASE


(Nostoc sp. PCC
7120)
no annotation 4 ILE F  34
VAL F   2
HIS F  25
LEU F  24
None
0.79A 3kp6A-4lkbF:
undetectable
3kp6B-4lkbF:
undetectable
3kp6A-4lkbF:
24.56
3kp6B-4lkbF:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB


(Homo sapiens)
PF01843
(DIL)
4 ILE A1678
VAL A1681
LEU A1685
HIS A1665
None
0.80A 3kp6A-4lnzA:
undetectable
3kp6B-4lnzA:
undetectable
3kp6A-4lnzA:
17.10
3kp6B-4lnzA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4los COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN


(Homo sapiens)
PF00084
(Sushi)
PF00431
(CUB)
4 ILE A 246
VAL A 201
LEU A 270
LEU A 223
None
0.88A 3kp6A-4losA:
undetectable
3kp6B-4losA:
undetectable
3kp6A-4losA:
21.88
3kp6B-4losA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4


(Homo sapiens)
PF01663
(Phosphodiest)
4 ILE A 365
VAL A  62
HIS A 362
LEU A  58
None
0.82A 3kp6A-4lr2A:
undetectable
3kp6B-4lr2A:
undetectable
3kp6A-4lr2A:
19.38
3kp6B-4lr2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Methanocaldococcus
jannaschii)
PF02350
(Epimerase_2)
4 ILE A 321
VAL A 323
LEU A 305
LEU A 285
None
0.87A 3kp6A-4nesA:
undetectable
3kp6B-4nesA:
undetectable
3kp6A-4nesA:
19.84
3kp6B-4nesA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE


(Mesorhizobium
japonicum)
PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C)
4 ILE A 145
VAL A   9
LEU A  11
LEU A 123
None
0.90A 3kp6A-4p7wA:
undetectable
3kp6B-4p7wA:
undetectable
3kp6A-4p7wA:
23.27
3kp6B-4p7wA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE


(Burkholderia
cenocepacia)
PF01063
(Aminotran_4)
4 VAL A 114
LEU A 116
HIS A  70
LEU A  71
None
None
PO4  A 401 ( 4.9A)
None
0.83A 3kp6A-4pbcA:
undetectable
3kp6B-4pbcA:
undetectable
3kp6A-4pbcA:
19.12
3kp6B-4pbcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1


(Bos taurus)
PF13516
(LRR_6)
4 ILE B 177
VAL B 172
LEU B 144
LEU B 125
None
0.92A 3kp6A-4peqB:
undetectable
3kp6B-4peqB:
undetectable
3kp6A-4peqB:
14.16
3kp6B-4peqB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2


(Rhodopseudomonas
palustris)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
4 ILE A 128
VAL A  47
LEU A  45
LEU A 257
None
0.79A 3kp6A-4r70A:
undetectable
3kp6B-4r70A:
undetectable
3kp6A-4r70A:
14.63
3kp6B-4r70A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE


(Salmonella
enterica)
PF00248
(Aldo_ket_red)
4 ILE A 266
VAL A 269
ARG A 270
LEU A 273
None
0.85A 3kp6A-4r9oA:
undetectable
3kp6B-4r9oA:
2.7
3kp6A-4r9oA:
21.16
3kp6B-4r9oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx1 PUTATIVE RRNA
METHYLTRANSFERASE


(Sorangium
cellulosum)
no annotation 4 ILE A  29
VAL A  31
LEU A 103
LEU A 135
None
0.76A 3kp6A-4rx1A:
undetectable
3kp6B-4rx1A:
undetectable
3kp6A-4rx1A:
20.51
3kp6B-4rx1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum)
no annotation 4 ILE B 780
VAL B 841
LEU B 748
LEU B 769
None
0.90A 3kp6A-4tmzB:
undetectable
3kp6B-4tmzB:
undetectable
3kp6A-4tmzB:
20.25
3kp6B-4tmzB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE


(Pseudomonas sp.
ADP)
PF01979
(Amidohydro_1)
4 ILE A 384
VAL A  58
LEU A 394
LEU A 425
None
0.92A 3kp6A-4v1yA:
0.7
3kp6B-4v1yA:
0.4
3kp6A-4v1yA:
13.74
3kp6B-4v1yA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w9r UNCHARACTERIZED
PROTEIN


(Capnocytophaga
ochracea)
PF00756
(Esterase)
4 ILE A 160
VAL A 135
LEU A  57
LEU A 144
None
0.65A 3kp6A-4w9rA:
undetectable
3kp6B-4w9rA:
undetectable
3kp6A-4w9rA:
18.97
3kp6B-4w9rA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 ILE A 174
VAL A 177
LEU A 201
LEU A 219
None
0.93A 3kp6A-4z64A:
undetectable
3kp6B-4z64A:
undetectable
3kp6A-4z64A:
12.36
3kp6B-4z64A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA


(Mycolicibacterium
smegmatis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 ILE A 169
VAL A 167
LEU A 176
LEU A 189
None
0.71A 3kp6A-5ah4A:
undetectable
3kp6B-5ah4A:
undetectable
3kp6A-5ah4A:
17.71
3kp6B-5ah4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6)
PF00202
(Aminotran_3)
4 ILE A 335
VAL A 293
LEU A 297
HIS A 302
None
0.90A 3kp6A-5ddsA:
1.3
3kp6B-5ddsA:
0.6
3kp6A-5ddsA:
14.53
3kp6B-5ddsA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct)
PF00291
(PALP)
4 ILE B 368
VAL B 370
LEU B  72
LEU B  61
None
0.90A 3kp6A-5ey5B:
undetectable
3kp6B-5ey5B:
undetectable
3kp6A-5ey5B:
18.01
3kp6B-5ey5B:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftp ANAPHASE-PROMOTING
COMPLEX SUBUNIT 8


(Schizosaccharomyces
pombe)
PF04049
(ANAPC8)
4 ILE A 158
VAL A 161
LEU A 165
LEU A 175
None
0.78A 3kp6A-5ftpA:
undetectable
3kp6B-5ftpA:
undetectable
3kp6A-5ftpA:
19.57
3kp6B-5ftpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv0 LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 1


(Mus musculus)
PF01299
(Lamp)
4 ILE A 333
VAL A 335
LEU A 339
LEU A 231
None
0.82A 3kp6A-5gv0A:
undetectable
3kp6B-5gv0A:
undetectable
3kp6A-5gv0A:
22.16
3kp6B-5gv0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis)
PF13354
(Beta-lactamase2)
4 VAL A 197
ARG A 203
LEU A 198
LEU A 206
None
0.92A 3kp6A-5hw3A:
undetectable
3kp6B-5hw3A:
1.8
3kp6A-5hw3A:
19.05
3kp6B-5hw3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa)
PF07992
(Pyr_redox_2)
4 ILE A 255
VAL A 257
LEU A 179
LEU A  56
None
0.80A 3kp6A-5jcnA:
undetectable
3kp6B-5jcnA:
undetectable
3kp6A-5jcnA:
16.09
3kp6B-5jcnA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcx (-)-ISOPIPERITENONE
REDUCTASE


(Mentha x
piperita)
PF00106
(adh_short)
4 ILE A  30
VAL A  32
LEU A  60
LEU A  53
None
0.86A 3kp6A-5lcxA:
undetectable
3kp6B-5lcxA:
undetectable
3kp6A-5lcxA:
23.21
3kp6B-5lcxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III


(Methanococcoides
burtonii)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 ILE A  92
VAL A  90
LEU A  83
LEU A  22
None
None
None
CL  A 504 (-3.9A)
0.87A 3kp6A-5macA:
undetectable
3kp6B-5macA:
undetectable
3kp6A-5macA:
14.48
3kp6B-5macA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum)
PF00668
(Condensation)
4 ILE A 145
VAL A 184
LEU A 198
LEU A 430
None
0.84A 3kp6A-5t81A:
undetectable
3kp6B-5t81A:
undetectable
3kp6A-5t81A:
15.82
3kp6B-5t81A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN


(Geobacillus sp.
Y4.1MC1)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C)
4 ILE A1492
VAL A1481
LEU A1478
LEU A1474
None
0.88A 3kp6A-5u89A:
undetectable
3kp6B-5u89A:
undetectable
3kp6A-5u89A:
9.64
3kp6B-5u89A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufq R11.1.6

(Sulfolobus
solfataricus)
no annotation 4 ILE C  19
VAL C  22
LEU C  58
LEU C  55
None
0.89A 3kp6A-5ufqC:
undetectable
3kp6B-5ufqC:
undetectable
3kp6A-5ufqC:
13.82
3kp6B-5ufqC:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE


(Rattus
norvegicus)
no annotation 4 ILE A  66
VAL A 191
LEU A 193
LEU A  86
None
0.71A 3kp6A-5wm0A:
undetectable
3kp6B-5wm0A:
undetectable
3kp6A-5wm0A:
undetectable
3kp6B-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum)
no annotation 4 ILE A 171
VAL A 169
LEU A 178
LEU A 191
None
0.79A 3kp6A-6d47A:
undetectable
3kp6B-6d47A:
undetectable
3kp6A-6d47A:
21.74
3kp6B-6d47A:
21.74