SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_S_TFPS202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 LEU A  22
SER A  23
PHE A  27
ILE A  30
 None
 0.99A 3ko0S-1bc5A:
undetectable		 3ko0S-1bc5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c25 CDC25A

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU A 411
PHE A 410
ILE A 382
CYH A 384
 None
 0.84A 3ko0S-1c25A:
undetectable		 3ko0S-1c25A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 333
SER A 334
PHE A 336
ILE A 371
 None
 0.97A 3ko0S-1ig8A:
0.0		 3ko0S-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162

(Helicobacter
pylori) 		PF01709
(Transcrip_reg) 		4 LEU A 109
SER A 111
PHE A 113
ILE A 226
 None
 0.86A 3ko0S-1mw7A:
undetectable		 3ko0S-1mw7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 LEU A 556
PHE A 555
ILE A 139
PHE A 501
 None
 0.96A 3ko0S-1obhA:
0.0		 3ko0S-1obhA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		4 LEU A 296
SER A 297
PHE A 301
ILE A 304
 None
 0.91A 3ko0S-1pztA:
undetectable		 3ko0S-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER

(Pyrococcus
furiosus) 		PF00005
(ABC_tran) 		4 SER A 181
PHE A  32
ILE A  47
PHE A  73
 None
 1.03A 3ko0S-1sgwA:
0.6		 3ko0S-1sgwA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 194
SER A 196
PHE A 195
ILE A 294
 None
 1.01A 3ko0S-1tp7A:
0.0		 3ko0S-1tp7A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tul TLP20

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF06088
(TLP-20) 		4 LEU A 101
SER A  65
PHE A 102
ILE A  45
 None
 0.99A 3ko0S-1tulA:
undetectable		 3ko0S-1tulA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 LEU A 321
SER A 323
PHE A 325
ILE A 270
 None
 0.96A 3ko0S-1tz7A:
0.3		 3ko0S-1tz7A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 159
PHE A 319
ILE A 281
PHE A 306
 None
 0.96A 3ko0S-1xzwA:
undetectable		 3ko0S-1xzwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 196
SER A 195
ILE A 188
PHE A 109
 None
 1.02A 3ko0S-1yj8A:
0.0		 3ko0S-1yj8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A 158
SER A 178
ILE A 197
CYH A 199
 None
 0.95A 3ko0S-1yx2A:
undetectable		 3ko0S-1yx2A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbp HYPOTHETICAL PROTEIN
VPA1032

(Vibrio
parahaemolyticus) 		PF07024
(ImpE) 		4 LEU A 104
SER A 106
PHE A 107
ILE A 126
 None
 0.85A 3ko0S-1zbpA:
undetectable		 3ko0S-1zbpA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN

(Taenia saginata) 		PF00011
(HSP20) 		4 LEU A 137
SER A 159
ILE A 183
PHE A 123
 None
 1.03A 3ko0S-2bolA:
undetectable		 3ko0S-2bolA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 4 LEU A  64
SER A  66
PHE A  65
ILE A  86
 None
 0.99A 3ko0S-2e8mA:
undetectable		 3ko0S-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		4 LEU A 130
SER A 128
PHE A 129
ILE A 317
 None
 0.73A 3ko0S-2fqxA:
undetectable		 3ko0S-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz0 INHIBITS
ATP-DEPENDENT CA(2+)
TRANSPORT ACTIVITY
OF PMC1P IN THE
VACUOLAR MEMBRANE
NYV1P
V-SNARE COMPONENT OF
THE VACUOLAR SNARE
COMPLEX INVOLVED IN
VESICLE FUSION

(Saccharomyces
cerevisiae) 		PF09426
(Nyv1_N) 		4 LEU A 132
SER A 134
PHE A 135
ILE A 108
 None
 0.97A 3ko0S-2fz0A:
undetectable		 3ko0S-2fz0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		4 LEU A 277
SER A 275
PHE A 276
ILE A 300
 None
 0.82A 3ko0S-2gnoA:
2.0		 3ko0S-2gnoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		4 LEU A   8
SER A  51
PHE A  50
ILE A  42
 None
 0.94A 3ko0S-2grmA:
0.0		 3ko0S-2grmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		4 LEU A  24
SER A  26
PHE A  27
ILE A  43
 None
 1.00A 3ko0S-2h1nA:
0.1		 3ko0S-2h1nA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knz UBIQUILIN-4

(Mus musculus) 		PF00627
(UBA) 		4 LEU A  18
SER A  20
PHE A  23
ILE A  44
 None
 0.97A 3ko0S-2knzA:
undetectable		 3ko0S-2knzA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 910
PHE A 909
ILE A 888
CYH A 892
 None
 0.78A 3ko0S-2ogvA:
undetectable		 3ko0S-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 910
SER A 908
PHE A 909
ILE A 888
 None
 0.91A 3ko0S-2ogvA:
undetectable		 3ko0S-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 LEU A 394
SER A 396
ILE A 443
PHE A 304
 None
 0.98A 3ko0S-2po4A:
1.7		 3ko0S-2po4A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 424
SER A 426
PHE A 427
ILE A 411
 None
 1.03A 3ko0S-2q1fA:
undetectable		 3ko0S-2q1fA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 160
PHE A 320
ILE A 282
PHE A 307
 None
 0.98A 3ko0S-2qfrA:
undetectable		 3ko0S-2qfrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 4 LEU A 205
PHE A 208
ILE A 171
PHE A 139
 None
 1.01A 3ko0S-2qgsA:
0.6		 3ko0S-2qgsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		4 LEU A 499
SER A 501
PHE A 503
ILE A 506
 None
 0.99A 3ko0S-2qnaA:
undetectable		 3ko0S-2qnaA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 589
SER A 566
PHE A 565
ILE A 587
 None
 1.02A 3ko0S-2v70A:
undetectable		 3ko0S-2v70A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		4 LEU A  35
SER A  37
PHE A  38
ILE A  82
 None
 0.96A 3ko0S-2vsgA:
undetectable		 3ko0S-2vsgA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 LEU A  65
SER A  67
PHE A  69
ILE A 145
 None
 0.81A 3ko0S-3ed3A:
undetectable		 3ko0S-3ed3A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
None
BFD  A 170 ( 4.0A)
None
 0.70A 3ko0S-3ef1A:
undetectable		 3ko0S-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 LEU A 238
SER A 240
ILE A 250
PHE A 196
 None
 0.83A 3ko0S-3ewdA:
undetectable		 3ko0S-3ewdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		4 LEU A  81
SER A 233
PHE A 232
ILE A 239
 None
 1.01A 3ko0S-3f9tA:
undetectable		 3ko0S-3f9tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		4 LEU A  45
PHE A  44
ILE A  40
PHE A 216
 None
 0.88A 3ko0S-3ftbA:
undetectable		 3ko0S-3ftbA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 476
SER A 475
ILE A 480
CYH A 483
 None
 0.92A 3ko0S-3g2fA:
0.4		 3ko0S-3g2fA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		4 LEU A 325
SER A 321
ILE A 330
PHE A 307
 None
 1.03A 3ko0S-3getA:
undetectable		 3ko0S-3getA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 0.87A 3ko0S-3h11A:
undetectable		 3ko0S-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP2
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		4 SER B 162
PHE B 120
ILE B 210
PHE C 217
 None
 1.01A 3ko0S-3j2jB:
undetectable		 3ko0S-3j2jB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S2,
MITOCHONDRIAL

(Bos taurus) 		PF00318
(Ribosomal_S2) 		4 LEU B 143
SER B 141
PHE B 140
PHE B 184
 None
 0.90A 3ko0S-3jd5B:
undetectable		 3ko0S-3jd5B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		4 LEU A 281
PHE A 280
ILE A 256
PHE A 263
 None
 0.95A 3ko0S-3jyoA:
undetectable		 3ko0S-3jyoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 LEU A 152
SER A 151
ILE A 205
CYH A 203
 None
 0.92A 3ko0S-3k28A:
undetectable		 3ko0S-3k28A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina) 		PF07063
(DUF1338) 		4 LEU A  12
PHE A   9
ILE A  41
PHE A 235
 None
 0.95A 3ko0S-3lhoA:
undetectable		 3ko0S-3lhoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF05259
(Herpes_UL1)
PF12524
(GlyL_C)
PF17488
(Herpes_glycoH_C) 		4 LEU B  72
ILE B  70
CYH A  90
PHE A  89
 None
 1.01A 3ko0S-3m1cB:
undetectable		 3ko0S-3m1cB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmb PUTATIVE SUGAR
HYDROLASE

(Bacteroides
ovatus) 		PF06439
(DUF1080) 		4 LEU A 123
PHE A 279
ILE A 135
PHE A 267
 None
 1.00A 3ko0S-3nmbA:
undetectable		 3ko0S-3nmbA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		4 LEU A  92
PHE A  91
ILE A 122
CYH A 114
 None
 0.88A 3ko0S-3pukA:
undetectable		 3ko0S-3pukA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 LEU A 185
SER A 116
PHE A 115
ILE A 108
 None
 0.99A 3ko0S-3qanA:
undetectable		 3ko0S-3qanA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 LEU A 332
PHE A 331
ILE A 314
PHE A 293
 None
 0.88A 3ko0S-3rreA:
undetectable		 3ko0S-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU X 225
SER X 221
ILE X 270
PHE X 274
 None
 0.92A 3ko0S-3rwkX:
undetectable		 3ko0S-3rwkX:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		4 LEU A   5
SER A  14
ILE A 235
CYH A 263
 None
 1.02A 3ko0S-3sp1A:
undetectable		 3ko0S-3sp1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		4 LEU A 340
ILE A 199
CYH A 197
PHE A 195
 None
 0.99A 3ko0S-3sqiA:
undetectable		 3ko0S-3sqiA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 107
SER A 105
ILE A  37
PHE A  52
 None
 0.91A 3ko0S-3toyA:
undetectable		 3ko0S-3toyA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 LEU A 292
SER A 218
PHE A 267
ILE A 318
 None
 0.93A 3ko0S-3ujpA:
undetectable		 3ko0S-3ujpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1

(Saccharomyces
cerevisiae) 		PF00581
(Rhodanese) 		4 LEU X 292
SER X 294
ILE X 203
PHE X 192
 None
 0.79A 3ko0S-3utnX:
undetectable		 3ko0S-3utnX:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A 334
PHE A 333
ILE A 236
PHE A 264
 None
 0.98A 3ko0S-3wnpA:
undetectable		 3ko0S-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 784
SER A 785
PHE A 789
ILE A 741
 None
 0.84A 3ko0S-4a4zA:
undetectable		 3ko0S-4a4zA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 755
SER A 754
ILE A 676
CYH A 698
 None
 0.98A 3ko0S-4at3A:
undetectable		 3ko0S-4at3A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU H 294
PHE H 295
ILE H 306
CYH H 304
 None
 0.90A 3ko0S-4cr4H:
undetectable		 3ko0S-4cr4H:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 LEU A 548
SER A 547
PHE A 581
ILE A 550
PHE A 419
 None
 1.49A 3ko0S-4ecnA:
undetectable		 3ko0S-4ecnA:
9.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eto PROTEIN S100-A4

(Homo sapiens) 		PF01023
(S_100) 		4 LEU A  42
ILE A  82
CYH A  86
PHE A  89
 None
 0.63A 3ko0S-4etoA:
16.7		 3ko0S-4etoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 SER A 711
PHE A 712
ILE A 773
PHE A 645
 None
 1.01A 3ko0S-4f0iA:
undetectable		 3ko0S-4f0iA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 LEU A  69
SER A  67
PHE A  68
ILE A  58
 LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
 1.01A 3ko0S-4g9kA:
undetectable		 3ko0S-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 LEU A 297
SER A 298
ILE A 364
CYH A 277
 None
 0.93A 3ko0S-4gxbA:
undetectable		 3ko0S-4gxbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 LEU A 208
SER A 210
ILE A 230
PHE A 261
 None
 0.93A 3ko0S-4i1aA:
undetectable		 3ko0S-4i1aA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila) 		PF02614
(UxaC) 		4 SER A 253
PHE A 257
ILE A 215
PHE A 146
 None
 0.91A 3ko0S-4i6vA:
undetectable		 3ko0S-4i6vA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		4 LEU A 152
PHE A 151
ILE A  30
PHE A  38
 None
 1.01A 3ko0S-4jhiA:
undetectable		 3ko0S-4jhiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		4 LEU A 253
PHE A 250
ILE A 215
PHE A 368
 None
 1.01A 3ko0S-4m46A:
undetectable		 3ko0S-4m46A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 LEU A  86
SER A  92
ILE A  55
CYH A  66
 None
 0.86A 3ko0S-4m9dA:
undetectable		 3ko0S-4m9dA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Burkholderia
ambifaria) 		PF03480
(DctP) 		4 LEU A 110
PHE A 107
ILE A 104
PHE A  95
 None
 1.02A 3ko0S-4n17A:
undetectable		 3ko0S-4n17A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 546
SER A 544
PHE A 545
ILE A 504
 None
 0.98A 3ko0S-4ot9A:
undetectable		 3ko0S-4ot9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 4

(Mus musculus) 		no annotation 4 LEU A1589
PHE A1586
ILE A1622
PHE A1635
 None
 1.03A 3ko0S-4otnA:
undetectable		 3ko0S-4otnA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Colwellia
psychrerythraea) 		PF02441
(Flavoprotein) 		4 LEU A  67
SER A  64
PHE A  66
ILE A  56
 None
 0.98A 3ko0S-4rheA:
undetectable		 3ko0S-4rheA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 LEU A 595
SER A 598
PHE A 600
ILE A 603
 None
 0.88A 3ko0S-4uzyA:
undetectable		 3ko0S-4uzyA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6q GLUCOSYLTRANSFERASE

(Streptococcus
agalactiae) 		no annotation 4 LEU A 328
SER A 326
ILE A  67
PHE A  98
 None
 0.81A 3ko0S-4w6qA:
undetectable		 3ko0S-4w6qA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
 0.63A 3ko0S-4xpzA:
undetectable		 3ko0S-4xpzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 LEU A 239
PHE A 240
ILE A 251
CYH A 249
 None
 0.98A 3ko0S-4z8xA:
undetectable		 3ko0S-4z8xA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 LEU A 239
SER A 237
ILE A  30
PHE A 250
 None
K  A1457 (-4.9A)
None
None
 1.02A 3ko0S-5ah1A:
undetectable		 3ko0S-5ah1A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 LEU A 660
SER A 662
PHE A 664
ILE A 436
 None
 1.02A 3ko0S-5czzA:
undetectable		 3ko0S-5czzA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 LEU A 281
PHE A 272
ILE A 653
PHE A 334
 None
 1.01A 3ko0S-5dkxA:
undetectable		 3ko0S-5dkxA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 291
SER A 253
PHE A 252
ILE A 289
 None
 0.95A 3ko0S-5dzvA:
undetectable		 3ko0S-5dzvA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 LEU A 384
SER A 386
ILE A 394
PHE A 350
 None
 1.01A 3ko0S-5f0oA:
undetectable		 3ko0S-5f0oA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.93A 3ko0S-5gjvA:
undetectable		 3ko0S-5gjvA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum) 		PF00190
(Cupin_1) 		4 LEU A 484
SER A 482
PHE A 483
ILE A 342
 None
 0.88A 3ko0S-5gylA:
undetectable		 3ko0S-5gylA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		4 LEU A 279
PHE A 270
ILE A 212
PHE A 219
 None
 0.96A 3ko0S-5hstA:
undetectable		 3ko0S-5hstA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 LEU A 148
SER A 149
PHE A 153
ILE A 156
 None
 0.94A 3ko0S-5i2qA:
7.2		 3ko0S-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE

(Plasmodium
falciparum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 104
ILE A 128
CYH A 100
PHE A  99
 None
 0.96A 3ko0S-5ilqA:
undetectable		 3ko0S-5ilqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 LEU A 415
PHE A 398
ILE A 443
PHE A  64
 None
 1.02A 3ko0S-5kcaA:
undetectable		 3ko0S-5kcaA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 LEU A 350
ILE A 362
CYH A 360
PHE A 359
 None
 0.99A 3ko0S-5l6sA:
undetectable		 3ko0S-5l6sA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 4 LEU A 366
SER A 368
ILE A  53
PHE A  21
 None
 0.98A 3ko0S-5ndxA:
undetectable		 3ko0S-5ndxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A2162
PHE A2165
ILE A2138
CYH A2142
 None
 0.77A 3ko0S-5nugA:
undetectable		 3ko0S-5nugA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 LEU A 761
SER A 759
PHE A 758
ILE A 738
 None
 0.88A 3ko0S-5nvrA:
undetectable		 3ko0S-5nvrA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pwy NUCLEAR AUTOANTIGEN
SP-100

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 815
SER A 797
ILE A 840
PHE A 847
 None
 0.83A 3ko0S-5pwyA:
undetectable		 3ko0S-5pwyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		4 LEU A 345
SER A 342
PHE A 344
ILE A  49
 None
 0.99A 3ko0S-5uldA:
undetectable		 3ko0S-5uldA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 439
ILE A 480
CYH A 494
PHE A 492
 None
 0.91A 3ko0S-5xgeA:
undetectable		 3ko0S-5xgeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 4 LEU A 159
SER A 161
ILE A 153
PHE A 316
 None
 0.70A 3ko0S-5z0cA:
undetectable		 3ko0S-5z0cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.95A 3ko0S-6byoA:
0.0		 3ko0S-6byoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 LEU A 431
SER A 433
PHE A 434
ILE A 780
 None
 1.02A 3ko0S-6d4jA:
undetectable		 3ko0S-6d4jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 LEU B 102
PHE B 103
ILE B 262
PHE B 254
 None
 0.90A 3ko0S-6evjB:
undetectable		 3ko0S-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 LEU A 682
PHE A 668
ILE A 626
CYH A 649
 None
 1.01A 3ko0S-6f9nA:
undetectable		 3ko0S-6f9nA:
24.49