SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_S_TFPS202
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bc5 | CHEMOTAXIS RECEPTORMETHYLTRANSFERASE (Salmonellaenterica) |
PF01739(CheR)PF03705(CheR_N) | 4 | LEU A 22SER A 23PHE A 27ILE A 30 | None | 0.99A | 3ko0S-1bc5A:undetectable | 3ko0S-1bc5A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c25 | CDC25A (Homo sapiens) |
PF00581(Rhodanese) | 4 | LEU A 411PHE A 410ILE A 382CYH A 384 | None | 0.84A | 3ko0S-1c25A:undetectable | 3ko0S-1c25A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ig8 | HEXOKINASE PII (Saccharomycescerevisiae) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 4 | LEU A 333SER A 334PHE A 336ILE A 371 | None | 0.97A | 3ko0S-1ig8A:0.0 | 3ko0S-1ig8A:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mw7 | HYPOTHETICAL PROTEINHP0162 (Helicobacterpylori) |
PF01709(Transcrip_reg) | 4 | LEU A 109SER A 111PHE A 113ILE A 226 | None | 0.86A | 3ko0S-1mw7A:undetectable | 3ko0S-1mw7A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obh | LEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2)PF14795(Leucyl-specific) | 4 | LEU A 556PHE A 555ILE A 139PHE A 501 | None | 0.96A | 3ko0S-1obhA:0.0 | 3ko0S-1obhA:7.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzt | BETA-1,4-GALACTOSYLTRANSFERASE 1 (Bos taurus) |
PF02709(Glyco_transf_7C)PF13733(Glyco_transf_7N) | 4 | LEU A 296SER A 297PHE A 301ILE A 304 | None | 0.91A | 3ko0S-1pztA:undetectable | 3ko0S-1pztA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgw | PUTATIVE ABCTRANSPORTER (Pyrococcusfuriosus) |
PF00005(ABC_tran) | 4 | SER A 181PHE A 32ILE A 47PHE A 73 | None | 1.03A | 3ko0S-1sgwA:0.6 | 3ko0S-1sgwA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tp7 | GENOME POLYPROTEIN (Rhinovirus A) |
PF00680(RdRP_1) | 4 | LEU A 194SER A 196PHE A 195ILE A 294 | None | 1.01A | 3ko0S-1tp7A:0.0 | 3ko0S-1tp7A:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tul | TLP20 (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF06088(TLP-20) | 4 | LEU A 101SER A 65PHE A 102ILE A 45 | None | 0.99A | 3ko0S-1tulA:undetectable | 3ko0S-1tulA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz7 | 4-ALPHA-GLUCANOTRANSFERASE (Aquifexaeolicus) |
PF02446(Glyco_hydro_77) | 4 | LEU A 321SER A 323PHE A 325ILE A 270 | None | 0.96A | 3ko0S-1tz7A:0.3 | 3ko0S-1tz7A:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzw | PURPLE ACIDPHOSPHATASE (Ipomoea batatas) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 4 | LEU A 159PHE A 319ILE A 281PHE A 306 | None | 0.96A | 3ko0S-1xzwA:undetectable | 3ko0S-1xzwA:12.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yj8 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 4 | LEU A 196SER A 195ILE A 188PHE A 109 | None | 1.02A | 3ko0S-1yj8A:0.0 | 3ko0S-1yj8A:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yx2 | AMINOMETHYLTRANSFERASE (Bacillussubtilis) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | LEU A 158SER A 178ILE A 197CYH A 199 | None | 0.95A | 3ko0S-1yx2A:undetectable | 3ko0S-1yx2A:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbp | HYPOTHETICAL PROTEINVPA1032 (Vibrioparahaemolyticus) |
PF07024(ImpE) | 4 | LEU A 104SER A 106PHE A 107ILE A 126 | None | 0.85A | 3ko0S-1zbpA:undetectable | 3ko0S-1zbpA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bol | SMALL HEAT SHOCKPROTEIN (Taenia saginata) |
PF00011(HSP20) | 4 | LEU A 137SER A 159ILE A 183PHE A 123 | None | 1.03A | 3ko0S-2bolA:undetectable | 3ko0S-2bolA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e8m | EPIDERMAL GROWTHFACTOR RECEPTORKINASE SUBSTRATE 8 (Homo sapiens) |
no annotation | 4 | LEU A 64SER A 66PHE A 65ILE A 86 | None | 0.99A | 3ko0S-2e8mA:undetectable | 3ko0S-2e8mA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fqx | MEMBRANE LIPOPROTEINTMPC (Treponemapallidum) |
PF02608(Bmp) | 4 | LEU A 130SER A 128PHE A 129ILE A 317 | None | 0.73A | 3ko0S-2fqxA:undetectable | 3ko0S-2fqxA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fz0 | INHIBITSATP-DEPENDENT CA(2+)TRANSPORT ACTIVITYOF PMC1P IN THEVACUOLAR MEMBRANE NYV1PV-SNARE COMPONENT OFTHE VACUOLAR SNARECOMPLEX INVOLVED INVESICLE FUSION (Saccharomycescerevisiae) |
PF09426(Nyv1_N) | 4 | LEU A 132SER A 134PHE A 135ILE A 108 | None | 0.97A | 3ko0S-2fz0A:undetectable | 3ko0S-2fz0A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gno | DNA POLYMERASE III,GAMMASUBUNIT-RELATEDPROTEIN (Thermotogamaritima) |
PF13177(DNA_pol3_delta2) | 4 | LEU A 277SER A 275PHE A 276ILE A 300 | None | 0.82A | 3ko0S-2gnoA:2.0 | 3ko0S-2gnoA:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2grm | PRGX (Enterococcusfaecalis) |
PF01381(HTH_3) | 4 | LEU A 8SER A 51PHE A 50ILE A 42 | None | 0.94A | 3ko0S-2grmA:0.0 | 3ko0S-2grmA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1n | OLIGOENDOPEPTIDASE F (Geobacillusstearothermophilus) |
PF01432(Peptidase_M3) | 4 | LEU A 24SER A 26PHE A 27ILE A 43 | None | 1.00A | 3ko0S-2h1nA:0.1 | 3ko0S-2h1nA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2knz | UBIQUILIN-4 (Mus musculus) |
PF00627(UBA) | 4 | LEU A 18SER A 20PHE A 23ILE A 44 | None | 0.97A | 3ko0S-2knzA:undetectable | 3ko0S-2knzA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | LEU A 910PHE A 909ILE A 888CYH A 892 | None | 0.78A | 3ko0S-2ogvA:undetectable | 3ko0S-2ogvA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | LEU A 910SER A 908PHE A 909ILE A 888 | None | 0.91A | 3ko0S-2ogvA:undetectable | 3ko0S-2ogvA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po4 | VIRION RNAPOLYMERASE (Escherichiavirus N4) |
no annotation | 4 | LEU A 394SER A 396ILE A 443PHE A 304 | None | 0.98A | 3ko0S-2po4A:1.7 | 3ko0S-2po4A:5.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1f | CHONDROITINASE (Bacteroidesthetaiotaomicron) |
PF02278(Lyase_8)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 4 | LEU A 424SER A 426PHE A 427ILE A 411 | None | 1.03A | 3ko0S-2q1fA:undetectable | 3ko0S-2q1fA:6.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfr | PURPLE ACIDPHOSPHATASE (Phaseolusvulgaris) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 4 | LEU A 160PHE A 320ILE A 282PHE A 307 | None | 0.98A | 3ko0S-2qfrA:undetectable | 3ko0S-2qfrA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgs | PROTEIN SE1688 (Staphylococcusepidermidis) |
no annotation | 4 | LEU A 205PHE A 208ILE A 171PHE A 139 | None | 1.01A | 3ko0S-2qgsA:0.6 | 3ko0S-2qgsA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qna | IMPORTIN SUBUNITBETA-1 (Homo sapiens) |
PF13513(HEAT_EZ) | 4 | LEU A 499SER A 501PHE A 503ILE A 506 | None | 0.99A | 3ko0S-2qnaA:undetectable | 3ko0S-2qnaA:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v70 | SLIT HOMOLOG 2PROTEIN N-PRODUCT (Homo sapiens) |
PF01462(LRRNT)PF13855(LRR_8) | 4 | LEU A 589SER A 566PHE A 565ILE A 587 | None | 1.02A | 3ko0S-2v70A:undetectable | 3ko0S-2v70A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsg | VARIANT SURFACEGLYCOPROTEIN ILTAT1.24 (Trypanosomabrucei) |
PF00913(Trypan_glycop) | 4 | LEU A 35SER A 37PHE A 38ILE A 82 | None | 0.96A | 3ko0S-2vsgA:undetectable | 3ko0S-2vsgA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed3 | PROTEINDISULFIDE-ISOMERASEMPD1 (Saccharomycescerevisiae) |
PF00085(Thioredoxin) | 4 | LEU A 65SER A 67PHE A 69ILE A 145 | None | 0.81A | 3ko0S-3ed3A:undetectable | 3ko0S-3ed3A:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ef1 | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | LEU A 230PHE A 229ILE A 175PHE A 317 | NoneNoneBFD A 170 ( 4.0A)None | 0.70A | 3ko0S-3ef1A:undetectable | 3ko0S-3ef1A:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewd | ADENOSINE DEAMINASE (Plasmodiumvivax) |
PF00962(A_deaminase) | 4 | LEU A 238SER A 240ILE A 250PHE A 196 | None | 0.83A | 3ko0S-3ewdA:undetectable | 3ko0S-3ewdA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9t | L-TYROSINEDECARBOXYLASE MFNA (Methanocaldococcusjannaschii) |
PF00282(Pyridoxal_deC) | 4 | LEU A 81SER A 233PHE A 232ILE A 239 | None | 1.01A | 3ko0S-3f9tA:undetectable | 3ko0S-3f9tA:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ftb | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Clostridiumacetobutylicum) |
PF00155(Aminotran_1_2) | 4 | LEU A 45PHE A 44ILE A 40PHE A 216 | None | 0.88A | 3ko0S-3ftbA:undetectable | 3ko0S-3ftbA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g2f | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-2 (Homo sapiens) |
PF00069(Pkinase) | 4 | LEU A 476SER A 475ILE A 480CYH A 483 | None | 0.92A | 3ko0S-3g2fA:0.4 | 3ko0S-3g2fA:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3get | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Campylobacterjejuni) |
PF00155(Aminotran_1_2) | 4 | LEU A 325SER A 321ILE A 330PHE A 307 | None | 1.03A | 3ko0S-3getA:undetectable | 3ko0S-3getA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h11 | CASP8 AND FADD-LIKEAPOPTOSIS REGULATOR (Homo sapiens) |
PF00656(Peptidase_C14) | 4 | LEU A 293SER A 290ILE A 257CYH A 259 | None | 0.87A | 3ko0S-3h11A:undetectable | 3ko0S-3h11A:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2j | PROTEIN VP2PROTEIN VP3 (Enterovirus B) |
PF00073(Rhv) | 4 | SER B 162PHE B 120ILE B 210PHE C 217 | None | 1.01A | 3ko0S-3j2jB:undetectable | 3ko0S-3j2jB:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd5 | 28S RIBOSOMALPROTEIN S2,MITOCHONDRIAL (Bos taurus) |
PF00318(Ribosomal_S2) | 4 | LEU B 143SER B 141PHE B 140PHE B 184 | None | 0.90A | 3ko0S-3jd5B:undetectable | 3ko0S-3jd5B:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jyo | QUINATE/SHIKIMATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF08501(Shikimate_dh_N) | 4 | LEU A 281PHE A 280ILE A 256PHE A 263 | None | 0.95A | 3ko0S-3jyoA:undetectable | 3ko0S-3jyoA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k28 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE2 (Bacillusanthracis) |
PF00202(Aminotran_3) | 4 | LEU A 152SER A 151ILE A 205CYH A 203 | None | 0.92A | 3ko0S-3k28A:undetectable | 3ko0S-3k28A:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lho | PUTATIVE HYDROLASE (Shewanellafrigidimarina) |
PF07063(DUF1338) | 4 | LEU A 12PHE A 9ILE A 41PHE A 235 | None | 0.95A | 3ko0S-3lhoA:undetectable | 3ko0S-3lhoA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1c | ENVELOPEGLYCOPROTEIN HENVELOPEGLYCOPROTEIN L (Humanalphaherpesvirus2) |
PF02489(Herpes_glycop_H)PF05259(Herpes_UL1)PF12524(GlyL_C)PF17488(Herpes_glycoH_C) | 4 | LEU B 72ILE B 70CYH A 90PHE A 89 | None | 1.01A | 3ko0S-3m1cB:undetectable | 3ko0S-3m1cB:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nmb | PUTATIVE SUGARHYDROLASE (Bacteroidesovatus) |
PF06439(DUF1080) | 4 | LEU A 123PHE A 279ILE A 135PHE A 267 | None | 1.00A | 3ko0S-3nmbA:undetectable | 3ko0S-3nmbA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3puk | SYNTAXIN-BINDINGPROTEIN 3 (Mus musculus) |
PF00995(Sec1) | 4 | LEU A 92PHE A 91ILE A 122CYH A 114 | None | 0.88A | 3ko0S-3pukA:undetectable | 3ko0S-3pukA:11.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qan | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE1 (Bacillushalodurans) |
PF00171(Aldedh) | 4 | LEU A 185SER A 116PHE A 115ILE A 108 | None | 0.99A | 3ko0S-3qanA:undetectable | 3ko0S-3qanA:12.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rre | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF01256(Carb_kinase)PF03853(YjeF_N) | 4 | LEU A 332PHE A 331ILE A 314PHE A 293 | None | 0.88A | 3ko0S-3rreA:undetectable | 3ko0S-3rreA:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwk | INULINASE (Aspergillusficuum) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | LEU X 225SER X 221ILE X 270PHE X 274 | None | 0.92A | 3ko0S-3rwkX:undetectable | 3ko0S-3rwkX:11.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sp1 | CYSTEINYL-TRNASYNTHETASE (Borreliellaburgdorferi) |
PF01406(tRNA-synt_1e) | 4 | LEU A 5SER A 14ILE A 235CYH A 263 | None | 1.02A | 3ko0S-3sp1A:undetectable | 3ko0S-3sp1A:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqi | KLLA0E03807P (Kluyveromyceslactis) |
PF16787(NDC10_II) | 4 | LEU A 340ILE A 199CYH A 197PHE A 195 | None | 0.99A | 3ko0S-3sqiA:undetectable | 3ko0S-3sqiA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3toy | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Bradyrhizobiumsp. ORS 278) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | LEU A 107SER A 105ILE A 37PHE A 52 | None | 0.91A | 3ko0S-3toyA:undetectable | 3ko0S-3toyA:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujp | MN TRANSPORTERSUBUNIT (Synechocystissp. PCC 6803) |
PF01297(ZnuA) | 4 | LEU A 292SER A 218PHE A 267ILE A 318 | None | 0.93A | 3ko0S-3ujpA:undetectable | 3ko0S-3ujpA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3utn | THIOSULFATESULFURTRANSFERASETUM1 (Saccharomycescerevisiae) |
PF00581(Rhodanese) | 4 | LEU X 292SER X 294ILE X 203PHE X 192 | None | 0.79A | 3ko0S-3utnX:undetectable | 3ko0S-3utnX:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnp | CYCLOISOMALTOOLIGOSACCHARIDEGLUCANOTRANSFERASE (Bacilluscirculans) |
PF13199(Glyco_hydro_66)PF16990(CBM_35) | 4 | LEU A 334PHE A 333ILE A 236PHE A 264 | None | 0.98A | 3ko0S-3wnpA:undetectable | 3ko0S-3wnpA:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4z | ANTIVIRAL HELICASESKI2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 4 | LEU A 784SER A 785PHE A 789ILE A 741 | None | 0.84A | 3ko0S-4a4zA:undetectable | 3ko0S-4a4zA:7.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | LEU A 755SER A 754ILE A 676CYH A 698 | None | 0.98A | 3ko0S-4at3A:undetectable | 3ko0S-4at3A:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cr4 | 26S PROTEASEREGULATORY SUBUNIT 7HOMOLOG (Saccharomycescerevisiae) |
PF00004(AAA) | 4 | LEU H 294PHE H 295ILE H 306CYH H 304 | None | 0.90A | 3ko0S-4cr4H:undetectable | 3ko0S-4cr4H:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 5 | LEU A 548SER A 547PHE A 581ILE A 550PHE A 419 | None | 1.49A | 3ko0S-4ecnA:undetectable | 3ko0S-4ecnA:9.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4eto | PROTEIN S100-A4 (Homo sapiens) |
PF01023(S_100) | 4 | LEU A 42ILE A 82CYH A 86PHE A 89 | None | 0.63A | 3ko0S-4etoA:16.7 | 3ko0S-4etoA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0i | HIGH AFFINITY NERVEGROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | SER A 711PHE A 712ILE A 773PHE A 645 | None | 1.01A | 3ko0S-4f0iA:undetectable | 3ko0S-4f0iA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g9k | ROTENONE-INSENSITIVENADH-UBIQUINONEOXIDOREDUCTASE (Saccharomycescerevisiae) |
PF07992(Pyr_redox_2) | 4 | LEU A 69SER A 67PHE A 68ILE A 58 | LEU A 69 ( 0.6A)SER A 67 ( 0.0A)PHE A 68 ( 1.3A)ILE A 58 ( 0.7A) | 1.01A | 3ko0S-4g9kA:undetectable | 3ko0S-4g9kA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxb | SORTING NEXIN-17 (Homo sapiens) |
no annotation | 4 | LEU A 297SER A 298ILE A 364CYH A 277 | None | 0.93A | 3ko0S-4gxbA:undetectable | 3ko0S-4gxbA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1a | RESPONSE REGULATORASPARTATEPHOSPHATASE I (Bacillussubtilis) |
PF13424(TPR_12) | 4 | LEU A 208SER A 210ILE A 230PHE A 261 | None | 0.93A | 3ko0S-4i1aA:undetectable | 3ko0S-4i1aA:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6v | AMIDOHYDROLASE 2 (Planctopiruslimnophila) |
PF02614(UxaC) | 4 | SER A 253PHE A 257ILE A 215PHE A 146 | None | 0.91A | 3ko0S-4i6vA:undetectable | 3ko0S-4i6vA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhi | MTN13 PROTEIN (Medicagotruncatula) |
PF00407(Bet_v_1) | 4 | LEU A 152PHE A 151ILE A 30PHE A 38 | None | 1.01A | 3ko0S-4jhiA:undetectable | 3ko0S-4jhiA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m46 | LUCIFERASE (Lampyristurkestanicus) |
PF00501(AMP-binding) | 4 | LEU A 253PHE A 250ILE A 215PHE A 368 | None | 1.01A | 3ko0S-4m46A:undetectable | 3ko0S-4m46A:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9d | ADENYLOSUCCINATESYNTHETASE (Bacillusanthracis) |
PF00709(Adenylsucc_synt) | 4 | LEU A 86SER A 92ILE A 55CYH A 66 | None | 0.86A | 3ko0S-4m9dA:undetectable | 3ko0S-4m9dA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n17 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Burkholderiaambifaria) |
PF03480(DctP) | 4 | LEU A 110PHE A 107ILE A 104PHE A 95 | None | 1.02A | 3ko0S-4n17A:undetectable | 3ko0S-4n17A:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ot9 | NUCLEAR FACTORNF-KAPPA-B P100SUBUNIT (Homo sapiens) |
PF12796(Ank_2) | 4 | LEU A 546SER A 544PHE A 545ILE A 504 | None | 0.98A | 3ko0S-4ot9A:undetectable | 3ko0S-4ot9A:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otn | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 4 (Mus musculus) |
no annotation | 4 | LEU A1589PHE A1586ILE A1622PHE A1635 | None | 1.03A | 3ko0S-4otnA:undetectable | 3ko0S-4otnA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rhe | 3-OCTAPRENYL-4-HYDROXYBENZOATECARBOXY-LYASE (Colwelliapsychrerythraea) |
PF02441(Flavoprotein) | 4 | LEU A 67SER A 64PHE A 66ILE A 56 | None | 0.98A | 3ko0S-4rheA:undetectable | 3ko0S-4rheA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzy | FLAGELLAR ASSOCIATEDPROTEIN (Chlamydomonasreinhardtii) |
PF12895(ANAPC3)PF13174(TPR_6) | 4 | LEU A 595SER A 598PHE A 600ILE A 603 | None | 0.88A | 3ko0S-4uzyA:undetectable | 3ko0S-4uzyA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6q | GLUCOSYLTRANSFERASE (Streptococcusagalactiae) |
no annotation | 4 | LEU A 328SER A 326ILE A 67PHE A 98 | None | 0.81A | 3ko0S-4w6qA:undetectable | 3ko0S-4w6qA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpz | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | LEU A 230PHE A 229ILE A 175PHE A 317 | None | 0.63A | 3ko0S-4xpzA:undetectable | 3ko0S-4xpzA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8x | ATP-DEPENDENT ZINCMETALLOPROTEASE FTSH (Aquifexaeolicus) |
PF00004(AAA)PF01434(Peptidase_M41) | 4 | LEU A 239PHE A 240ILE A 251CYH A 249 | None | 0.98A | 3ko0S-4z8xA:undetectable | 3ko0S-4z8xA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah1 | TRIACYLGLYCEROLLIPASE (Clostridiumbotulinum) |
no annotation | 4 | LEU A 239SER A 237ILE A 30PHE A 250 | None K A1457 (-4.9A)NoneNone | 1.02A | 3ko0S-5ah1A:undetectable | 3ko0S-5ah1A:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czz | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Staphylococcusaureus) |
PF13395(HNH_4)PF16592(Cas9_REC) | 4 | LEU A 660SER A 662PHE A 664ILE A 436 | None | 1.02A | 3ko0S-5czzA:undetectable | 3ko0S-5czzA:6.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkx | ALPHAGLUCOSIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 4 | LEU A 281PHE A 272ILE A 653PHE A 334 | None | 1.01A | 3ko0S-5dkxA:undetectable | 3ko0S-5dkxA:7.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dzv | PROTEIN PCDHA7 (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | LEU A 291SER A 253PHE A 252ILE A 289 | None | 0.95A | 3ko0S-5dzvA:undetectable | 3ko0S-5dzvA:11.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f0o | COHESIN SUBUNITPDS5,KLTH0D07062P,KLTH0D07062P,KLTH0D07062P,COHESIN SUBUNIT PDS5,KLTH0D07062P,KLTH0D07062P,KLTH0D07062P,COHESIN SUBUNIT PDS5,KLTH0D07062P,KLTH0D07062P,KLTH0D07062P,COHESIN SUBUNIT PDS5,KLTH0D07062P,KLTH0D07062P (Lachanceathermotolerans) |
no annotation | 4 | LEU A 384SER A 386ILE A 394PHE A 350 | None | 1.01A | 3ko0S-5f0oA:undetectable | 3ko0S-5f0oA:7.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gjv | VOLTAGE-DEPENDENTL-TYPE CALCIUMCHANNEL SUBUNITALPHA-1S (Oryctolaguscuniculus) |
PF00520(Ion_trans)PF08763(Ca_chan_IQ)PF16905(GPHH) | 4 | LEU A 471SER A 473PHE A 475ILE A 441 | None | 0.93A | 3ko0S-5gjvA:undetectable | 3ko0S-5gjvA:5.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gyl | LEGUMIN-LIKE PROTEIN (Cicer arietinum) |
PF00190(Cupin_1) | 4 | LEU A 484SER A 482PHE A 483ILE A 342 | None | 0.88A | 3ko0S-5gylA:undetectable | 3ko0S-5gylA:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hst | POLYKETIDE SYNTHASETYPE I (Bacillusamyloliquefaciens) |
PF14765(PS-DH) | 4 | LEU A 279PHE A 270ILE A 212PHE A 219 | None | 0.96A | 3ko0S-5hstA:undetectable | 3ko0S-5hstA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2q | EF-HANDDOMAIN-CONTAININGPROTEIN D2 (Homo sapiens) |
PF13405(EF-hand_6) | 4 | LEU A 148SER A 149PHE A 153ILE A 156 | None | 0.94A | 3ko0S-5i2qA:7.2 | 3ko0S-5i2qA:25.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilq | ASPARTATECARBAMOYLTRANSFERASE (Plasmodiumfalciparum) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | LEU A 104ILE A 128CYH A 100PHE A 99 | None | 0.96A | 3ko0S-5ilqA:undetectable | 3ko0S-5ilqA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kca | CEREBELLIN-1,CEREBELLIN-1,CEREBELLIN-1,GLUTAMATE RECEPTORIONOTROPIC, DELTA-2 (Homo sapiens) |
PF00386(C1q)PF01094(ANF_receptor) | 4 | LEU A 415PHE A 398ILE A 443PHE A 64 | None | 1.02A | 3ko0S-5kcaA:undetectable | 3ko0S-5kcaA:7.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6s | GLUCOSE-1-PHOSPHATEADENYLYLTRANSFERASE (Escherichiacoli) |
PF00483(NTP_transferase) | 4 | LEU A 350ILE A 362CYH A 360PHE A 359 | None | 0.99A | 3ko0S-5l6sA:undetectable | 3ko0S-5l6sA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ndx | GLYCOSYL HYDROLASE (Rhizobiumleguminosarum) |
no annotation | 4 | LEU A 366SER A 368ILE A 53PHE A 21 | None | 0.98A | 3ko0S-5ndxA:undetectable | 3ko0S-5ndxA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 4 | SER A2162PHE A2165ILE A2138CYH A2142 | None | 0.77A | 3ko0S-5nugA:undetectable | 3ko0S-5nugA:1.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvr | TELOMERE LENGTHREGULATOR PROTEINRIF1 (Saccharomycescerevisiae) |
PF12231(Rif1_N) | 4 | LEU A 761SER A 759PHE A 758ILE A 738 | None | 0.88A | 3ko0S-5nvrA:undetectable | 3ko0S-5nvrA:6.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5pwy | NUCLEAR AUTOANTIGENSP-100 (Homo sapiens) |
PF00439(Bromodomain) | 4 | LEU A 815SER A 797ILE A 840PHE A 847 | None | 0.83A | 3ko0S-5pwyA:undetectable | 3ko0S-5pwyA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uld | TRANSPORTER, NADCFAMILY (Vibrio cholerae) |
PF00939(Na_sulph_symp) | 4 | LEU A 345SER A 342PHE A 344ILE A 49 | None | 0.99A | 3ko0S-5uldA:undetectable | 3ko0S-5uldA:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xge | UNCHARACTERIZEDPROTEIN PA0861 (Pseudomonasaeruginosa) |
no annotation | 4 | LEU A 439ILE A 480CYH A 494PHE A 492 | None | 0.91A | 3ko0S-5xgeA:undetectable | 3ko0S-5xgeA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0c | NEROL DEHYDROGENASE (Persicariaminor) |
no annotation | 4 | LEU A 159SER A 161ILE A 153PHE A 316 | None | 0.70A | 3ko0S-5z0cA:undetectable | 3ko0S-5z0cA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byo | VOLTAGE-DEPENDENTL-TYPE CALCIUMCHANNEL SUBUNITALPHA-1S (Oryctolaguscuniculus) |
no annotation | 4 | LEU A 471SER A 473PHE A 475ILE A 441 | None | 0.95A | 3ko0S-6byoA:0.0 | 3ko0S-6byoA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d4j | PROTEIN PATCHEDHOMOLOG 1 (Homo sapiens) |
no annotation | 4 | LEU A 431SER A 433PHE A 434ILE A 780 | None | 1.02A | 3ko0S-6d4jA:undetectable | 3ko0S-6d4jA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evj | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Avirus) |
no annotation | 4 | LEU B 102PHE B 103ILE B 262PHE B 254 | None | 0.90A | 3ko0S-6evjB:undetectable | 3ko0S-6evjB:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f9n | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTORSUBUNIT 1 (Homo sapiens) |
no annotation | 4 | LEU A 682PHE A 668ILE A 626CYH A 649 | None | 1.01A | 3ko0S-6f9nA:undetectable | 3ko0S-6f9nA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c2y | PROTEIN (LUMAZINESYNTHASE) (Spinaciaoleracea) |
PF00885(DMRL_synthase) | 3 | GLU A 33LEU A 36ASP A 37 | None | 0.32A | 3ko0T-1c2yA:undetectable | 3ko0T-1c2yA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcz | BETA-METHYLASPARTASE (Clostridiumtetanomorphum) |
PF05034(MAAL_N)PF07476(MAAL_C) | 3 | GLU A 294LEU A 291ASP A 290 | None | 0.39A | 3ko0T-1kczA:undetectable | 3ko0T-1kczA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1j | HEAT SHOCK PROTEASEHTRA (Thermotogamaritima) |
PF13365(Trypsin_2) | 3 | GLU A 125LEU A 126ASP A 127 | None | 0.42A | 3ko0T-1l1jA:undetectable | 3ko0T-1l1jA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obb | ALPHA-GLUCOSIDASE (Thermotogamaritima) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 3 | GLU A 343LEU A 346ASP A 347 | None | 0.14A | 3ko0T-1obbA:undetectable | 3ko0T-1obbA:12.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rw2 | ATP-DEPENDENT DNAHELICASE II, 80 KDASUBUNIT (Homo sapiens) |
PF08785(Ku_PK_bind) | 3 | GLU A 63LEU A 66ASP A 67 | None | 0.25A | 3ko0T-1rw2A:undetectable | 3ko0T-1rw2A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdh | NEI ENDONUCLEASEVIII-LIKE 1 (Homo sapiens) |
PF01149(Fapy_DNA_glyco)PF06831(H2TH)PF09292(Neil1-DNA_bind) | 3 | GLU A 163LEU A 166ASP A 167 | None | 0.39A | 3ko0T-1tdhA:undetectable | 3ko0T-1tdhA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjk | MOLYBDOPTERINCONVERTING FACTOR,SUBUNIT 1 (Pyrococcusfuriosus) |
PF02597(ThiS) | 3 | GLU A 37LEU A 34ASP A 33 | None | 0.43A | 3ko0T-1vjkA:undetectable | 3ko0T-1vjkA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vki | HYPOTHETICAL PROTEINATU3699 (Agrobacteriumfabrum) |
PF04073(tRNA_edit) | 3 | GLU A 67LEU A 127ASP A 126 | None | 0.40A | 3ko0T-1vkiA:undetectable | 3ko0T-1vkiA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wgn | UBIQUITIN ASSOCIATEDPROTEIN (Homo sapiens) |
no annotation | 3 | GLU A 48LEU A 51ASP A 52 | None | 0.18A | 3ko0T-1wgnA:undetectable | 3ko0T-1wgnA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9u | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Homo sapiens) |
PF08969(USP8_dimer) | 3 | GLU A 49LEU A 52ASP A 53 | None | 0.30A | 3ko0T-2a9uA:undetectable | 3ko0T-2a9uA:25.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bnh | RIBONUCLEASEINHIBITOR (Sus scrofa) |
PF13516(LRR_6) | 3 | GLU A 130LEU A 133ASP A 134 | None | 0.26A | 3ko0T-2bnhA:undetectable | 3ko0T-2bnhA:13.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d2s | EXOCYST COMPLEXCOMPONENT EXO84 (Saccharomycescerevisiae) |
PF16528(Exo84_C) | 3 | GLU A 557LEU A 560ASP A 561 | None | 0.39A | 3ko0T-2d2sA:undetectable | 3ko0T-2d2sA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dzd | PYRUVATE CARBOXYLASE (Geobacillusthermodenitrificans) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | GLU A 112LEU A 115ASP A 116 | None | 0.41A | 3ko0T-2dzdA:undetectable | 3ko0T-2dzdA:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e9f | ARGININOSUCCINATELYASE (Thermusthermophilus) |
PF00206(Lyase_1)PF14698(ASL_C2) | 3 | GLU A 329LEU A 332ASP A 333 | None | 0.21A | 3ko0T-2e9fA:0.8 | 3ko0T-2e9fA:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmu | PUTATIVEPYRIDOXAMINE5-PHOSPHATE-DEPENDENT DEHYDRASE, WBDK (Escherichiacoli) |
PF01041(DegT_DnrJ_EryC1) | 3 | GLU A 278LEU A 281ASP A 282 | None | 0.37A | 3ko0T-2gmuA:undetectable | 3ko0T-2gmuA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i10 | PUTATIVE TETRTRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF00440(TetR_N) | 3 | GLU A 58LEU A 61ASP A 62 | None | 0.42A | 3ko0T-2i10A:undetectable | 3ko0T-2i10A:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j1d | DISHEVELED-ASSOCIATED ACTIVATOR OFMORPHOGENESIS 1 (Homo sapiens) |
PF02181(FH2) | 3 | GLU G 746LEU G 743ASP G 742 | None | 0.40A | 3ko0T-2j1dG:undetectable | 3ko0T-2j1dG:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5b | TYROSYL-TRNASYNTHETASE (Acanthamoebapolyphagamimivirus) |
PF00579(tRNA-synt_1b) | 3 | GLU A 125LEU A 128ASP A 129 | GLU A 125 ( 0.6A)LEU A 128 ( 0.6A)ASP A 129 ( 0.6A) | 0.24A | 3ko0T-2j5bA:undetectable | 3ko0T-2j5bA:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2khz | C-MYC-RESPONSIVEPROTEIN RCL (Rattusnorvegicus) |
PF05014(Nuc_deoxyrib_tr) | 3 | GLU A 140LEU A 143ASP A 144 | None | 0.40A | 3ko0T-2khzA:undetectable | 3ko0T-2khzA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l6c | THIOREDOXIN (Desulfovibriovulgaris) |
PF00085(Thioredoxin) | 3 | GLU A 38LEU A 41ASP A 42 | None | 0.34A | 3ko0T-2l6cA:undetectable | 3ko0T-2l6cA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lse | FOUR HELIX BUNDLEPROTEIN (syntheticconstruct) |
no annotation | 3 | GLU A 13LEU A 16ASP A 17 | None | 0.40A | 3ko0T-2lseA:undetectable | 3ko0T-2lseA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mn2 | YMOB (Yersiniaenterocolitica) |
PF10757(YbaJ) | 3 | GLU A 77LEU A 80ASP A 81 | None | 0.42A | 3ko0T-2mn2A:undetectable | 3ko0T-2mn2A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7r | CXE CARBOXYLESTERASE (Actinidiaeriantha) |
PF07859(Abhydrolase_3) | 3 | GLU A 232LEU A 229ASP A 228 | None | 0.40A | 3ko0T-2o7rA:undetectable | 3ko0T-2o7rA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pn1 | CARBAMOYLPHOSPHATESYNTHASE LARGESUBUNIT (Exiguobacteriumsibiricum) |
PF02655(ATP-grasp_3) | 3 | GLU A 239LEU A 242ASP A 243 | None | 0.43A | 3ko0T-2pn1A:undetectable | 3ko0T-2pn1A:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pod | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME (Burkholderiapseudomallei) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | GLU A 160LEU A 163ASP A 164 | None | 0.31A | 3ko0T-2podA:undetectable | 3ko0T-2podA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rae | TRANSCRIPTIONALREGULATOR, ACRRFAMILY PROTEIN (Rhodococcusjostii) |
PF00440(TetR_N) | 3 | GLU A 172LEU A 175ASP A 176 | None | 0.30A | 3ko0T-2raeA:undetectable | 3ko0T-2raeA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rvj | EPITHELIAL SPLICINGREGULATORY PROTEIN 1 (Homo sapiens) |
PF00076(RRM_1) | 3 | GLU A 459LEU A 462ASP A 463 | None | 0.34A | 3ko0T-2rvjA:undetectable | 3ko0T-2rvjA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tmk | THYMIDYLATE KINASE (Saccharomycescerevisiae) |
PF02223(Thymidylate_kin) | 3 | GLU A 171LEU A 168ASP A 169 | None | 0.44A | 3ko0T-2tmkA:undetectable | 3ko0T-2tmkA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbn | TERMINASE LARGESUBUNIT (Bacillus phageSPP1) |
PF17288(Terminase_3C) | 3 | GLU A 354LEU A 357ASP A 358 | None | 0.13A | 3ko0T-2wbnA:undetectable | 3ko0T-2wbnA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsb | GALACTITOLDEHYDROGENASE (Rhodobactersphaeroides) |
PF13561(adh_short_C2) | 3 | GLU A 208LEU A 211ASP A 212 | None | 0.43A | 3ko0T-2wsbA:undetectable | 3ko0T-2wsbA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh3 | SPD1 NUCLEASE (Streptococcuspyogenes) |
PF13930(Endonuclea_NS_2) | 3 | GLU A 164LEU A 167ASP A 168 | None | 0.20A | 3ko0T-2xh3A:undetectable | 3ko0T-2xh3A:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z7e | NIFU-LIKE PROTEIN (Aquifexaeolicus) |
PF01592(NifU_N) | 3 | GLU A 7LEU A 10ASP A 11 | None | 0.24A | 3ko0T-2z7eA:undetectable | 3ko0T-2z7eA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zc4 | PENICILLIN-BINDINGPROTEIN 2X (Streptococcuspneumoniae) |
PF03793(PASTA) | 3 | GLU C 652LEU C 649ASP C 648 | None | 0.43A | 3ko0T-2zc4C:undetectable | 3ko0T-2zc4C:27.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bt7 | TRNA(URACIL-5-)-METHYLTRANSFERASE (Escherichiacoli) |
PF05958(tRNA_U5-meth_tr) | 3 | GLU A 201LEU A 204ASP A 205 | None | 0.25A | 3ko0T-3bt7A:undetectable | 3ko0T-3bt7A:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c90 | PHOSPHORIBOSYL-ATPPYROPHOSPHATASE (Mycobacteriumtuberculosis) |
no annotation | 3 | GLU X 16LEU X 13ASP X 12 | None | 0.38A | 3ko0T-3c90X:undetectable | 3ko0T-3c90X:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3crl | DIHYDROLIPOYLLYSINE-RESIDUEACETYLTRANSFERASECOMPONENT OFPYRUVATEDEHYDROGENASECOMPLEX,MITOCHONDRIAL (Homo sapiens) |
PF00364(Biotin_lipoyl) | 3 | GLU C 179LEU C 165ASP C 164 | None | 0.41A | 3ko0T-3crlC:undetectable | 3ko0T-3crlC:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dra | PROTEINFARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNITALPHA (Candidaalbicans) |
PF01239(PPTA) | 3 | GLU A 94LEU A 97ASP A 98 | None | 0.20A | 3ko0T-3draA:undetectable | 3ko0T-3draA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e6a | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Oryza sativa) |
no annotation | 3 | GLU O 139LEU O 329ASP O 328 | None | 0.41A | 3ko0T-3e6aO:undetectable | 3ko0T-3e6aO:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eoo | METHYLISOCITRATELYASE (Burkholderiapseudomallei) |
PF13714(PEP_mutase) | 3 | GLU A 285LEU A 288ASP A 289 | None | 0.41A | 3ko0T-3eooA:undetectable | 3ko0T-3eooA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd9 | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF16806(ExsD) | 3 | GLU A 132LEU A 135ASP A 136 | None | 0.35A | 3ko0T-3fd9A:undetectable | 3ko0T-3fd9A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g6i | PUTATIVE OUTERMEMBRANE PROTEIN,PART OF CARBOHYDRATEBINDING COMPLEX (Bacteroidesthetaiotaomicron) |
PF12875(DUF3826) | 3 | GLU A 145LEU A 148ASP A 149 | None | 0.19A | 3ko0T-3g6iA:undetectable | 3ko0T-3g6iA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2q | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Marinobacterhydrocarbonoclasticus) |
PF00365(PFK) | 3 | GLU A 169LEU A 172ASP A 173 | None | 0.23A | 3ko0T-3k2qA:0.6 | 3ko0T-3k2qA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k30 | HISTAMINEDEHYDROGENASE (Pimelobactersimplex) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 3 | GLU A 215LEU A 218ASP A 219 | None | 0.24A | 3ko0T-3k30A:undetectable | 3ko0T-3k30A:8.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7x | LIN0763 PROTEIN (Listeriainnocua) |
PF03663(Glyco_hydro_76) | 3 | GLU A 281LEU A 278ASP A 277 | None | 0.42A | 3ko0T-3k7xA:undetectable | 3ko0T-3k7xA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7g | XAA-PRO DIPEPTIDASE (Alteromonas sp.) |
PF00557(Peptidase_M24) | 3 | GLU A 294LEU A 297ASP A 298 | None | 0.33A | 3ko0T-3l7gA:undetectable | 3ko0T-3l7gA:11.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgj | UNCHARACTERIZEDPROTEIN MJ1480 (Methanocaldococcusjannaschii) |
PF04455(Saccharop_dh_N) | 3 | GLU A 74LEU A 71ASP A 70 | None | 0.38A | 3ko0T-3mgjA:undetectable | 3ko0T-3mgjA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3og4 | INTERLEUKIN-29 (Homo sapiens) |
PF15177(IL28A) | 3 | GLU A 92LEU A 95ASP A 96 | None | 0.41A | 3ko0T-3og4A:undetectable | 3ko0T-3og4A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p1t | PUTATIVEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Burkholderiapseudomallei) |
PF00155(Aminotran_1_2) | 3 | GLU A 237LEU A 240ASP A 241 | None | 0.37A | 3ko0T-3p1tA:undetectable | 3ko0T-3p1tA:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl5 | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcusmutans) |
PF02645(DegV) | 3 | GLU A 150LEU A 153ASP A 154 | None | 0.22A | 3ko0T-3pl5A:undetectable | 3ko0T-3pl5A:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q88 | GLUCOSE-6-PHOSPHATEISOMERASE (Francisellatularensis) |
PF00342(PGI) | 3 | GLU A 215LEU A 218ASP A 219 | None | 0.43A | 3ko0T-3q88A:0.6 | 3ko0T-3q88A:9.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpf | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
PF06824(Glyco_hydro_125) | 3 | GLU A 417LEU A 420ASP A 421 | EDO A 433 ( 4.4A)EDO A 435 ( 4.5A)None | 0.31A | 3ko0T-3qpfA:undetectable | 3ko0T-3qpfA:13.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qzy | BACULOVIRUSSULFHYDRYL OXIDASEAC92 (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF05214(Baculo_p33) | 3 | GLU A 177LEU A 180ASP A 181 | None | 0.34A | 3ko0T-3qzyA:1.8 | 3ko0T-3qzyA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv2 | S-ADENOSYLMETHIONINESYNTHASE (Mycobacteriummarinum) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 3 | GLU A 76LEU A 79ASP A 80 | None | 0.13A | 3ko0T-3rv2A:undetectable | 3ko0T-3rv2A:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3shr | CGMP-DEPENDENTPROTEIN KINASE 1 (Bos taurus) |
PF00027(cNMP_binding) | 3 | GLU A 95LEU A 98ASP A 99 | None | 0.31A | 3ko0T-3shrA:undetectable | 3ko0T-3shrA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t4w | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Sulfitobactersp. NAS-14.1) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | GLU A 151LEU A 154ASP A 155 | None | 0.31A | 3ko0T-3t4wA:undetectable | 3ko0T-3t4wA:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ts7 | GERANYLTRANSTRANSFERASE (Methylococcuscapsulatus) |
PF00348(polyprenyl_synt) | 3 | GLU A 19LEU A 22ASP A 23 | None | 0.26A | 3ko0T-3ts7A:undetectable | 3ko0T-3ts7A:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvl | HOMOSERINEO-ACETYLTRANSFERASE (Streptomyceslavendulae) |
PF00561(Abhydrolase_1) | 3 | GLU A 258LEU A 261ASP A 262 | None | 0.22A | 3ko0T-3vvlA:undetectable | 3ko0T-3vvlA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vz0 | PUTATIVENAD-DEPENDENTALDEHYDEDEHYDROGENASE (Gluconobacteroxydans) |
PF00171(Aldedh) | 3 | GLU A 313LEU A 316ASP A 317 | None | 0.41A | 3ko0T-3vz0A:undetectable | 3ko0T-3vz0A:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzp | RIBOSOMAL PROTEIN S6 (Thermusthermophilus) |
no annotation | 3 | GLU A 25LEU A 22ASP A 21 | None | 0.43A | 3ko0T-3zzpA:undetectable | 3ko0T-3zzpA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ack | TSSL (Francisellatularensis) |
PF09850(DotU) | 3 | GLU A 8LEU A 11ASP A 12 | NoneNone BR A1156 ( 4.4A) | 0.37A | 3ko0T-4ackA:undetectable | 3ko0T-4ackA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4am2 | BACTERIOFERRITIN (Blastochlorisviridis) |
PF00210(Ferritin) | 3 | GLU A 135LEU A 138ASP A 139 | None | 0.29A | 3ko0T-4am2A:undetectable | 3ko0T-4am2A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4axz | PUTATIVE ANTIGEN P35 (Borreliellaburgdorferi) |
PF05714(Borrelia_lipo_1) | 3 | GLU A 270LEU A 271ASP A 272 | None | 0.39A | 3ko0T-4axzA:0.9 | 3ko0T-4axzA:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e44 | CENTROMERE PROTEIN S (Homo sapiens) |
PF15630(CENP-S) | 3 | GLU A 33LEU A 36ASP A 37 | None | 0.43A | 3ko0T-4e44A:undetectable | 3ko0T-4e44A:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ee9 | ENDOGLUCANASE (unculturedbacterium) |
PF00150(Cellulase) | 3 | GLU A 253LEU A 256ASP A 257 | None | 0.34A | 3ko0T-4ee9A:undetectable | 3ko0T-4ee9A:12.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4eto | PROTEIN S100-A4 (Homo sapiens) |
PF01023(S_100) | 3 | GLU A 6LEU A 9ASP A 10 | None | 0.35A | 3ko0T-4etoA:16.6 | 3ko0T-4etoA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fd6 | ARYLALKYLAMINEN-ACETYLTRANSFERASE2 (Aedes aegypti) |
PF00583(Acetyltransf_1) | 3 | GLU A 157LEU A 160ASP A 161 | None | 0.26A | 3ko0T-4fd6A:undetectable | 3ko0T-4fd6A:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hn3 | LMO1757 PROTEIN (Listeriamonocytogenes) |
PF07537(CamS) | 3 | GLU A 110LEU A 113ASP A 114 | None | 0.20A | 3ko0T-4hn3A:undetectable | 3ko0T-4hn3A:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i5j | SERINE/THREONINE-PROTEIN PHOSPHATASE 2AREGULATORY SUBUNITB'' SUBUNIT ALPHA (Homo sapiens) |
PF13499(EF-hand_7) | 3 | GLU A 438LEU A 441ASP A 442 | None | 0.34A | 3ko0T-4i5jA:2.6 | 3ko0T-4i5jA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i99 | CHROMOSOME PARTITIONPROTEIN SMC (Pyrococcusfuriosus) |
PF02463(SMC_N) | 3 | GLU A1117LEU A1114ASP A1113 | None | 0.37A | 3ko0T-4i99A:undetectable | 3ko0T-4i99A:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kbm | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycobacteriumtuberculosis) |
PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1) | 3 | GLU A 266LEU A 269ASP A 270 | None | 0.28A | 3ko0T-4kbmA:undetectable | 3ko0T-4kbmA:11.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ne5 | CENTROMERE PROTEIN S (Homo sapiens) |
PF15630(CENP-S) | 3 | GLU A 33LEU A 36ASP A 37 | None | 0.33A | 3ko0T-4ne5A:undetectable | 3ko0T-4ne5A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pl2 | DUAL-SPECIFICITY RNAMETHYLTRANSFERASERLMN (Escherichiacoli) |
no annotation | 3 | GLU B 193LEU B 196ASP B 197 | None | 0.34A | 3ko0T-4pl2B:undetectable | 3ko0T-4pl2B:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9o | PUTATIVE ALDO/KETOREDUCTASE (Salmonellaenterica) |
PF00248(Aldo_ket_red) | 3 | GLU A 39LEU A 42ASP A 43 | None | 0.21A | 3ko0T-4r9oA:undetectable | 3ko0T-4r9oA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tps | CHROMOSOMALREPLICATIONINITIATOR PROTEINDNAA (Bacillussubtilis) |
PF11638(DnaA_N) | 3 | GLU B 2LEU B 5ASP B 6 | None | 0.34A | 3ko0T-4tpsB:undetectable | 3ko0T-4tpsB:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xxn | ESX-1SECRETION-ASSOCIATEDPROTEIN ESPB (Mycobacteriumtuberculosis) |
no annotation | 3 | GLU A 185LEU A 188ASP A 189 | None | 0.18A | 3ko0T-4xxnA:undetectable | 3ko0T-4xxnA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xy3 | ESX-1SECRETION-ASSOCIATEDPROTEIN ESPB (Mycobacteriumtuberculosis) |
no annotation | 3 | GLU A 185LEU A 188ASP A 189 | None | 0.29A | 3ko0T-4xy3A:undetectable | 3ko0T-4xy3A:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0h | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEGAPC1, CYTOSOLIC (Arabidopsisthaliana) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | GLU O 134LEU O 324ASP O 323 | None | 0.36A | 3ko0T-4z0hO:undetectable | 3ko0T-4z0hO:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zwo | ORGANOPHOSPHATEANHYDROLASE/PROLIDASE (Alteromonas sp.) |
PF00557(Peptidase_M24) | 3 | GLU A 294LEU A 297ASP A 298 | None | 0.19A | 3ko0T-4zwoA:undetectable | 3ko0T-4zwoA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5abm | RETINALDEHYDROGENASE 1 (Ovis aries) |
PF00171(Aldedh) | 3 | GLU A 351LEU A 354ASP A 355 | None | 0.23A | 3ko0T-5abmA:undetectable | 3ko0T-5abmA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bux | 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN]DEHYDRATASE FABZ (Yersinia pestis) |
PF07977(FabA) | 3 | GLU A 11LEU A 14ASP A 15 | None | 0.41A | 3ko0T-5buxA:undetectable | 3ko0T-5buxA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cqf | L-LYSINE6-MONOOXYGENASE (Pseudomonassyringae groupgenomosp. 3) |
PF13434(K_oxygenase) | 3 | GLU A 424LEU A 42ASP A 41 | None | 0.43A | 3ko0T-5cqfA:undetectable | 3ko0T-5cqfA:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e57 | TRANSCRIPTIONREGULATOR AMTR (Mycolicibacteriumsmegmatis) |
PF00440(TetR_N) | 3 | GLU A 24LEU A 27ASP A 28 | None | 0.19A | 3ko0T-5e57A:1.0 | 3ko0T-5e57A:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eo6 | COPROPORPHYRINOGENOXIDASE (Acinetobacterbaumannii) |
PF01218(Coprogen_oxidas) | 3 | GLU A 14LEU A 17ASP A 18 | None | 0.19A | 3ko0T-5eo6A:undetectable | 3ko0T-5eo6A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eue | PUTATIVESPHINGOSINE-1-PHOSPHATE LYASE (Symbiobacteriumthermophilum) |
PF00282(Pyridoxal_deC) | 3 | GLU A 372LEU A 375ASP A 376 | None | 0.22A | 3ko0T-5eueA:undetectable | 3ko0T-5eueA:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hr6 | RLMN METHYLASE (Escherichiacoli) |
PF04055(Radical_SAM) | 3 | GLU A 193LEU A 196ASP A 197 | None MG A 504 (-4.9A)None | 0.40A | 3ko0T-5hr6A:undetectable | 3ko0T-5hr6A:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5itq | ENDONUCLEASE 8-LIKE1 (Homo sapiens) |
PF01149(Fapy_DNA_glyco)PF06831(H2TH)PF09292(Neil1-DNA_bind) | 3 | GLU A 163LEU A 166ASP A 167 | None | 0.43A | 3ko0T-5itqA:1.9 | 3ko0T-5itqA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kht | TROPOMYOSIN ALPHA-1CHAIN,GENERALCONTROL PROTEIN GCN4 (Homo sapiens;Saccharomycescerevisiae) |
no annotation | 3 | GLU A 16LEU A 19ASP A 20 | None | 0.14A | 3ko0T-5khtA:undetectable | 3ko0T-5khtA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l8a | PEROXIN 14 (Trypanosomabrucei) |
PF04695(Pex14_N) | 3 | GLU A 16LEU A 19ASP A 20 | 6RB A 101 (-3.7A)None6RB A 101 ( 4.2A) | 0.43A | 3ko0T-5l8aA:undetectable | 3ko0T-5l8aA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msc | CARBOXYLIC ACIDREDUCTASE (Nocardiaiowensis) |
PF00501(AMP-binding) | 3 | GLU A 407LEU A 410ASP A 411 | None | 0.37A | 3ko0T-5mscA:undetectable | 3ko0T-5mscA:6.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT B (Methanothermococcusthermolithotrophicus) |
PF02754(CCG) | 3 | GLU B 206LEU B 209ASP B 210 | None | 0.26A | 3ko0T-5odrB:undetectable | 3ko0T-5odrB:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oet | GLUTATHIONESYNTHETASE-LIKEEFFECTOR 30(GPA-GSS30-APO) (Globoderapallida) |
no annotation | 3 | GLU B 49LEU B 52ASP B 53 | None | 0.23A | 3ko0T-5oetB:undetectable | 3ko0T-5oetB:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vr3 | BRAF (Homo sapiens) |
no annotation | 3 | GLU A 62LEU A 65ASP A 66 | None | 0.18A | 3ko0T-5vr3A:undetectable | 3ko0T-5vr3A:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyk | CHIMERA PROTEIN OFBRS DOMAIN OF BRAFAND CC-SAM DOMAIN OFKSR1,SERINE/THREONINE-PROTEIN KINASEB-RAF (Homo sapiens) |
no annotation | 3 | GLU A1062LEU A1065ASP A1066 | None | 0.22A | 3ko0T-5vykA:undetectable | 3ko0T-5vykA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xns | CHROMOSOME PARTITIONPROTEIN SMC (Pyrococcusfuriosus) |
PF02463(SMC_N) | 3 | GLU A1117LEU A1114ASP A1113 | None | 0.39A | 3ko0T-5xnsA:undetectable | 3ko0T-5xnsA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Komagataellaphaffii) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 3 | GLU B 320LEU B 323ASP B 324 | None | 0.32A | 3ko0T-5xogB:undetectable | 3ko0T-5xogB:5.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xto | FAD-LINKEDSULFHYDRYL OXIDASE (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF05214(Baculo_p33) | 3 | GLU A 177LEU A 180ASP A 181 | None | 0.40A | 3ko0T-5xtoA:undetectable | 3ko0T-5xtoA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yhp | COLD ACTIVE PROLINEIMINOPEPTIDASE (Glaciozymaantarctica) |
no annotation | 3 | GLU A 162LEU A 165ASP A 166 | None | 0.23A | 3ko0T-5yhpA:undetectable | 3ko0T-5yhpA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 3 | GLU A1813LEU A1712ASP A1713 | None | 0.44A | 3ko0T-5zalA:undetectable | 3ko0T-5zalA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fea | VANADIUMNITROGENASE, DELTASUBUNIT, VNFG (Azotobactervinelandii) |
no annotation | 3 | GLU C 85LEU C 88ASP C 89 | None | 0.39A | 3ko0T-6feaC:undetectable | 3ko0T-6feaC:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ggp | AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Thermotogamaritima) |
no annotation | 3 | GLU A 60LEU A 57ASP A 56 | None | 0.42A | 3ko0T-6ggpA:undetectable | 3ko0T-6ggpA:23.71 |