SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_S_TFPS202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE


(Salmonella
enterica)
PF01739
(CheR)
PF03705
(CheR_N)
4 LEU A  22
SER A  23
PHE A  27
ILE A  30
None
0.99A 3ko0S-1bc5A:
undetectable
3ko0S-1bc5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c25 CDC25A

(Homo sapiens)
PF00581
(Rhodanese)
4 LEU A 411
PHE A 410
ILE A 382
CYH A 384
None
0.84A 3ko0S-1c25A:
undetectable
3ko0S-1c25A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
4 LEU A 333
SER A 334
PHE A 336
ILE A 371
None
0.97A 3ko0S-1ig8A:
0.0
3ko0S-1ig8A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162


(Helicobacter
pylori)
PF01709
(Transcrip_reg)
4 LEU A 109
SER A 111
PHE A 113
ILE A 226
None
0.86A 3ko0S-1mw7A:
undetectable
3ko0S-1mw7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific)
4 LEU A 556
PHE A 555
ILE A 139
PHE A 501
None
0.96A 3ko0S-1obhA:
0.0
3ko0S-1obhA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1


(Bos taurus)
PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N)
4 LEU A 296
SER A 297
PHE A 301
ILE A 304
None
0.91A 3ko0S-1pztA:
undetectable
3ko0S-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER


(Pyrococcus
furiosus)
PF00005
(ABC_tran)
4 SER A 181
PHE A  32
ILE A  47
PHE A  73
None
1.03A 3ko0S-1sgwA:
0.6
3ko0S-1sgwA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A)
PF00680
(RdRP_1)
4 LEU A 194
SER A 196
PHE A 195
ILE A 294
None
1.01A 3ko0S-1tp7A:
0.0
3ko0S-1tp7A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tul TLP20

(Autographa
californica
multiple
nucleopolyhedrovirus)
PF06088
(TLP-20)
4 LEU A 101
SER A  65
PHE A 102
ILE A  45
None
0.99A 3ko0S-1tulA:
undetectable
3ko0S-1tulA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE


(Aquifex
aeolicus)
PF02446
(Glyco_hydro_77)
4 LEU A 321
SER A 323
PHE A 325
ILE A 270
None
0.96A 3ko0S-1tz7A:
0.3
3ko0S-1tz7A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE


(Ipomoea batatas)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
4 LEU A 159
PHE A 319
ILE A 281
PHE A 306
None
0.96A 3ko0S-1xzwA:
undetectable
3ko0S-1xzwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
4 LEU A 196
SER A 195
ILE A 188
PHE A 109
None
1.02A 3ko0S-1yj8A:
0.0
3ko0S-1yj8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE


(Bacillus
subtilis)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 LEU A 158
SER A 178
ILE A 197
CYH A 199
None
0.95A 3ko0S-1yx2A:
undetectable
3ko0S-1yx2A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbp HYPOTHETICAL PROTEIN
VPA1032


(Vibrio
parahaemolyticus)
PF07024
(ImpE)
4 LEU A 104
SER A 106
PHE A 107
ILE A 126
None
0.85A 3ko0S-1zbpA:
undetectable
3ko0S-1zbpA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN


(Taenia saginata)
PF00011
(HSP20)
4 LEU A 137
SER A 159
ILE A 183
PHE A 123
None
1.03A 3ko0S-2bolA:
undetectable
3ko0S-2bolA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8


(Homo sapiens)
no annotation 4 LEU A  64
SER A  66
PHE A  65
ILE A  86
None
0.99A 3ko0S-2e8mA:
undetectable
3ko0S-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC


(Treponema
pallidum)
PF02608
(Bmp)
4 LEU A 130
SER A 128
PHE A 129
ILE A 317
None
0.73A 3ko0S-2fqxA:
undetectable
3ko0S-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz0 INHIBITS
ATP-DEPENDENT CA(2+)
TRANSPORT ACTIVITY
OF PMC1P IN THE
VACUOLAR MEMBRANE
NYV1P
V-SNARE COMPONENT OF
THE VACUOLAR SNARE
COMPLEX INVOLVED IN
VESICLE FUSION


(Saccharomyces
cerevisiae)
PF09426
(Nyv1_N)
4 LEU A 132
SER A 134
PHE A 135
ILE A 108
None
0.97A 3ko0S-2fz0A:
undetectable
3ko0S-2fz0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN


(Thermotoga
maritima)
PF13177
(DNA_pol3_delta2)
4 LEU A 277
SER A 275
PHE A 276
ILE A 300
None
0.82A 3ko0S-2gnoA:
2.0
3ko0S-2gnoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis)
PF01381
(HTH_3)
4 LEU A   8
SER A  51
PHE A  50
ILE A  42
None
0.94A 3ko0S-2grmA:
0.0
3ko0S-2grmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus)
PF01432
(Peptidase_M3)
4 LEU A  24
SER A  26
PHE A  27
ILE A  43
None
1.00A 3ko0S-2h1nA:
0.1
3ko0S-2h1nA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knz UBIQUILIN-4

(Mus musculus)
PF00627
(UBA)
4 LEU A  18
SER A  20
PHE A  23
ILE A  44
None
0.97A 3ko0S-2knzA:
undetectable
3ko0S-2knzA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 LEU A 910
PHE A 909
ILE A 888
CYH A 892
None
0.78A 3ko0S-2ogvA:
undetectable
3ko0S-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 LEU A 910
SER A 908
PHE A 909
ILE A 888
None
0.91A 3ko0S-2ogvA:
undetectable
3ko0S-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE


(Escherichia
virus N4)
no annotation 4 LEU A 394
SER A 396
ILE A 443
PHE A 304
None
0.98A 3ko0S-2po4A:
1.7
3ko0S-2po4A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron)
PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt)
4 LEU A 424
SER A 426
PHE A 427
ILE A 411
None
1.03A 3ko0S-2q1fA:
undetectable
3ko0S-2q1fA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE


(Phaseolus
vulgaris)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
4 LEU A 160
PHE A 320
ILE A 282
PHE A 307
None
0.98A 3ko0S-2qfrA:
undetectable
3ko0S-2qfrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis)
no annotation 4 LEU A 205
PHE A 208
ILE A 171
PHE A 139
None
1.01A 3ko0S-2qgsA:
0.6
3ko0S-2qgsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1


(Homo sapiens)
PF13513
(HEAT_EZ)
4 LEU A 499
SER A 501
PHE A 503
ILE A 506
None
0.99A 3ko0S-2qnaA:
undetectable
3ko0S-2qnaA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v70 SLIT HOMOLOG 2
PROTEIN N-PRODUCT


(Homo sapiens)
PF01462
(LRRNT)
PF13855
(LRR_8)
4 LEU A 589
SER A 566
PHE A 565
ILE A 587
None
1.02A 3ko0S-2v70A:
undetectable
3ko0S-2v70A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsg VARIANT SURFACE
GLYCOPROTEIN ILTAT
1.24


(Trypanosoma
brucei)
PF00913
(Trypan_glycop)
4 LEU A  35
SER A  37
PHE A  38
ILE A  82
None
0.96A 3ko0S-2vsgA:
undetectable
3ko0S-2vsgA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1


(Saccharomyces
cerevisiae)
PF00085
(Thioredoxin)
4 LEU A  65
SER A  67
PHE A  69
ILE A 145
None
0.81A 3ko0S-3ed3A:
undetectable
3ko0S-3ed3A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03031
(NIF)
PF12738
(PTCB-BRCT)
4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
None
None
BFD  A 170 ( 4.0A)
None
0.70A 3ko0S-3ef1A:
undetectable
3ko0S-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax)
PF00962
(A_deaminase)
4 LEU A 238
SER A 240
ILE A 250
PHE A 196
None
0.83A 3ko0S-3ewdA:
undetectable
3ko0S-3ewdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA


(Methanocaldococcus
jannaschii)
PF00282
(Pyridoxal_deC)
4 LEU A  81
SER A 233
PHE A 232
ILE A 239
None
1.01A 3ko0S-3f9tA:
undetectable
3ko0S-3f9tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Clostridium
acetobutylicum)
PF00155
(Aminotran_1_2)
4 LEU A  45
PHE A  44
ILE A  40
PHE A 216
None
0.88A 3ko0S-3ftbA:
undetectable
3ko0S-3ftbA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2


(Homo sapiens)
PF00069
(Pkinase)
4 LEU A 476
SER A 475
ILE A 480
CYH A 483
None
0.92A 3ko0S-3g2fA:
0.4
3ko0S-3g2fA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF00155
(Aminotran_1_2)
4 LEU A 325
SER A 321
ILE A 330
PHE A 307
None
1.03A 3ko0S-3getA:
undetectable
3ko0S-3getA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR


(Homo sapiens)
PF00656
(Peptidase_C14)
4 LEU A 293
SER A 290
ILE A 257
CYH A 259
None
0.87A 3ko0S-3h11A:
undetectable
3ko0S-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP2
PROTEIN VP3


(Enterovirus B)
PF00073
(Rhv)
4 SER B 162
PHE B 120
ILE B 210
PHE C 217
None
1.01A 3ko0S-3j2jB:
undetectable
3ko0S-3j2jB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S2,
MITOCHONDRIAL


(Bos taurus)
PF00318
(Ribosomal_S2)
4 LEU B 143
SER B 141
PHE B 140
PHE B 184
None
0.90A 3ko0S-3jd5B:
undetectable
3ko0S-3jd5B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF08501
(Shikimate_dh_N)
4 LEU A 281
PHE A 280
ILE A 256
PHE A 263
None
0.95A 3ko0S-3jyoA:
undetectable
3ko0S-3jyoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2


(Bacillus
anthracis)
PF00202
(Aminotran_3)
4 LEU A 152
SER A 151
ILE A 205
CYH A 203
None
0.92A 3ko0S-3k28A:
undetectable
3ko0S-3k28A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina)
PF07063
(DUF1338)
4 LEU A  12
PHE A   9
ILE A  41
PHE A 235
None
0.95A 3ko0S-3lhoA:
undetectable
3ko0S-3lhoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L


(Human
alphaherpesvirus
2)
PF02489
(Herpes_glycop_H)
PF05259
(Herpes_UL1)
PF12524
(GlyL_C)
PF17488
(Herpes_glycoH_C)
4 LEU B  72
ILE B  70
CYH A  90
PHE A  89
None
1.01A 3ko0S-3m1cB:
undetectable
3ko0S-3m1cB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmb PUTATIVE SUGAR
HYDROLASE


(Bacteroides
ovatus)
PF06439
(DUF1080)
4 LEU A 123
PHE A 279
ILE A 135
PHE A 267
None
1.00A 3ko0S-3nmbA:
undetectable
3ko0S-3nmbA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3


(Mus musculus)
PF00995
(Sec1)
4 LEU A  92
PHE A  91
ILE A 122
CYH A 114
None
0.88A 3ko0S-3pukA:
undetectable
3ko0S-3pukA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1


(Bacillus
halodurans)
PF00171
(Aldedh)
4 LEU A 185
SER A 116
PHE A 115
ILE A 108
None
0.99A 3ko0S-3qanA:
undetectable
3ko0S-3qanA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermotoga
maritima)
PF01256
(Carb_kinase)
PF03853
(YjeF_N)
4 LEU A 332
PHE A 331
ILE A 314
PHE A 293
None
0.88A 3ko0S-3rreA:
undetectable
3ko0S-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 LEU X 225
SER X 221
ILE X 270
PHE X 274
None
0.92A 3ko0S-3rwkX:
undetectable
3ko0S-3rwkX:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE


(Borreliella
burgdorferi)
PF01406
(tRNA-synt_1e)
4 LEU A   5
SER A  14
ILE A 235
CYH A 263
None
1.02A 3ko0S-3sp1A:
undetectable
3ko0S-3sp1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis)
PF16787
(NDC10_II)
4 LEU A 340
ILE A 199
CYH A 197
PHE A 195
None
0.99A 3ko0S-3sqiA:
undetectable
3ko0S-3sqiA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Bradyrhizobium
sp. ORS 278)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 107
SER A 105
ILE A  37
PHE A  52
None
0.91A 3ko0S-3toyA:
undetectable
3ko0S-3toyA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT


(Synechocystis
sp. PCC 6803)
PF01297
(ZnuA)
4 LEU A 292
SER A 218
PHE A 267
ILE A 318
None
0.93A 3ko0S-3ujpA:
undetectable
3ko0S-3ujpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utn THIOSULFATE
SULFURTRANSFERASE
TUM1


(Saccharomyces
cerevisiae)
PF00581
(Rhodanese)
4 LEU X 292
SER X 294
ILE X 203
PHE X 192
None
0.79A 3ko0S-3utnX:
undetectable
3ko0S-3utnX:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE


(Bacillus
circulans)
PF13199
(Glyco_hydro_66)
PF16990
(CBM_35)
4 LEU A 334
PHE A 333
ILE A 236
PHE A 264
None
0.98A 3ko0S-3wnpA:
undetectable
3ko0S-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
4 LEU A 784
SER A 785
PHE A 789
ILE A 741
None
0.84A 3ko0S-4a4zA:
undetectable
3ko0S-4a4zA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 LEU A 755
SER A 754
ILE A 676
CYH A 698
None
0.98A 3ko0S-4at3A:
undetectable
3ko0S-4at3A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG


(Saccharomyces
cerevisiae)
PF00004
(AAA)
4 LEU H 294
PHE H 295
ILE H 306
CYH H 304
None
0.90A 3ko0S-4cr4H:
undetectable
3ko0S-4cr4H:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN


(Bacteroides
thetaiotaomicron)
PF14660
(DUF4458)
5 LEU A 548
SER A 547
PHE A 581
ILE A 550
PHE A 419
None
1.49A 3ko0S-4ecnA:
undetectable
3ko0S-4ecnA:
9.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eto PROTEIN S100-A4

(Homo sapiens)
PF01023
(S_100)
4 LEU A  42
ILE A  82
CYH A  86
PHE A  89
None
0.63A 3ko0S-4etoA:
16.7
3ko0S-4etoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 SER A 711
PHE A 712
ILE A 773
PHE A 645
None
1.01A 3ko0S-4f0iA:
undetectable
3ko0S-4f0iA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE


(Saccharomyces
cerevisiae)
PF07992
(Pyr_redox_2)
4 LEU A  69
SER A  67
PHE A  68
ILE A  58
LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
1.01A 3ko0S-4g9kA:
undetectable
3ko0S-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens)
no annotation 4 LEU A 297
SER A 298
ILE A 364
CYH A 277
None
0.93A 3ko0S-4gxbA:
undetectable
3ko0S-4gxbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I


(Bacillus
subtilis)
PF13424
(TPR_12)
4 LEU A 208
SER A 210
ILE A 230
PHE A 261
None
0.93A 3ko0S-4i1aA:
undetectable
3ko0S-4i1aA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila)
PF02614
(UxaC)
4 SER A 253
PHE A 257
ILE A 215
PHE A 146
None
0.91A 3ko0S-4i6vA:
undetectable
3ko0S-4i6vA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula)
PF00407
(Bet_v_1)
4 LEU A 152
PHE A 151
ILE A  30
PHE A  38
None
1.01A 3ko0S-4jhiA:
undetectable
3ko0S-4jhiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus)
PF00501
(AMP-binding)
4 LEU A 253
PHE A 250
ILE A 215
PHE A 368
None
1.01A 3ko0S-4m46A:
undetectable
3ko0S-4m46A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE


(Bacillus
anthracis)
PF00709
(Adenylsucc_synt)
4 LEU A  86
SER A  92
ILE A  55
CYH A  66
None
0.86A 3ko0S-4m9dA:
undetectable
3ko0S-4m9dA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Burkholderia
ambifaria)
PF03480
(DctP)
4 LEU A 110
PHE A 107
ILE A 104
PHE A  95
None
1.02A 3ko0S-4n17A:
undetectable
3ko0S-4n17A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT


(Homo sapiens)
PF12796
(Ank_2)
4 LEU A 546
SER A 544
PHE A 545
ILE A 504
None
0.98A 3ko0S-4ot9A:
undetectable
3ko0S-4ot9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 4


(Mus musculus)
no annotation 4 LEU A1589
PHE A1586
ILE A1622
PHE A1635
None
1.03A 3ko0S-4otnA:
undetectable
3ko0S-4otnA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE


(Colwellia
psychrerythraea)
PF02441
(Flavoprotein)
4 LEU A  67
SER A  64
PHE A  66
ILE A  56
None
0.98A 3ko0S-4rheA:
undetectable
3ko0S-4rheA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN


(Chlamydomonas
reinhardtii)
PF12895
(ANAPC3)
PF13174
(TPR_6)
4 LEU A 595
SER A 598
PHE A 600
ILE A 603
None
0.88A 3ko0S-4uzyA:
undetectable
3ko0S-4uzyA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6q GLUCOSYLTRANSFERASE

(Streptococcus
agalactiae)
no annotation 4 LEU A 328
SER A 326
ILE A  67
PHE A  98
None
0.81A 3ko0S-4w6qA:
undetectable
3ko0S-4w6qA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03031
(NIF)
PF12738
(PTCB-BRCT)
4 LEU A 230
PHE A 229
ILE A 175
PHE A 317
None
0.63A 3ko0S-4xpzA:
undetectable
3ko0S-4xpzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH


(Aquifex
aeolicus)
PF00004
(AAA)
PF01434
(Peptidase_M41)
4 LEU A 239
PHE A 240
ILE A 251
CYH A 249
None
0.98A 3ko0S-4z8xA:
undetectable
3ko0S-4z8xA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE


(Clostridium
botulinum)
no annotation 4 LEU A 239
SER A 237
ILE A  30
PHE A 250
None
K  A1457 (-4.9A)
None
None
1.02A 3ko0S-5ah1A:
undetectable
3ko0S-5ah1A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Staphylococcus
aureus)
PF13395
(HNH_4)
PF16592
(Cas9_REC)
4 LEU A 660
SER A 662
PHE A 664
ILE A 436
None
1.02A 3ko0S-5czzA:
undetectable
3ko0S-5czzA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110)
4 LEU A 281
PHE A 272
ILE A 653
PHE A 334
None
1.01A 3ko0S-5dkxA:
undetectable
3ko0S-5dkxA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
4 LEU A 291
SER A 253
PHE A 252
ILE A 289
None
0.95A 3ko0S-5dzvA:
undetectable
3ko0S-5dzvA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P


(Lachancea
thermotolerans)
no annotation 4 LEU A 384
SER A 386
ILE A 394
PHE A 350
None
1.01A 3ko0S-5f0oA:
undetectable
3ko0S-5f0oA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S


(Oryctolagus
cuniculus)
PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH)
4 LEU A 471
SER A 473
PHE A 475
ILE A 441
None
0.93A 3ko0S-5gjvA:
undetectable
3ko0S-5gjvA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum)
PF00190
(Cupin_1)
4 LEU A 484
SER A 482
PHE A 483
ILE A 342
None
0.88A 3ko0S-5gylA:
undetectable
3ko0S-5gylA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I


(Bacillus
amyloliquefaciens)
PF14765
(PS-DH)
4 LEU A 279
PHE A 270
ILE A 212
PHE A 219
None
0.96A 3ko0S-5hstA:
undetectable
3ko0S-5hstA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2


(Homo sapiens)
PF13405
(EF-hand_6)
4 LEU A 148
SER A 149
PHE A 153
ILE A 156
None
0.94A 3ko0S-5i2qA:
7.2
3ko0S-5i2qA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE


(Plasmodium
falciparum)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 LEU A 104
ILE A 128
CYH A 100
PHE A  99
None
0.96A 3ko0S-5ilqA:
undetectable
3ko0S-5ilqA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2


(Homo sapiens)
PF00386
(C1q)
PF01094
(ANF_receptor)
4 LEU A 415
PHE A 398
ILE A 443
PHE A  64
None
1.02A 3ko0S-5kcaA:
undetectable
3ko0S-5kcaA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF00483
(NTP_transferase)
4 LEU A 350
ILE A 362
CYH A 360
PHE A 359
None
0.99A 3ko0S-5l6sA:
undetectable
3ko0S-5l6sA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum)
no annotation 4 LEU A 366
SER A 368
ILE A  53
PHE A  21
None
0.98A 3ko0S-5ndxA:
undetectable
3ko0S-5ndxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
4 SER A2162
PHE A2165
ILE A2138
CYH A2142
None
0.77A 3ko0S-5nugA:
undetectable
3ko0S-5nugA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1


(Saccharomyces
cerevisiae)
PF12231
(Rif1_N)
4 LEU A 761
SER A 759
PHE A 758
ILE A 738
None
0.88A 3ko0S-5nvrA:
undetectable
3ko0S-5nvrA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pwy NUCLEAR AUTOANTIGEN
SP-100


(Homo sapiens)
PF00439
(Bromodomain)
4 LEU A 815
SER A 797
ILE A 840
PHE A 847
None
0.83A 3ko0S-5pwyA:
undetectable
3ko0S-5pwyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY


(Vibrio cholerae)
PF00939
(Na_sulph_symp)
4 LEU A 345
SER A 342
PHE A 344
ILE A  49
None
0.99A 3ko0S-5uldA:
undetectable
3ko0S-5uldA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861


(Pseudomonas
aeruginosa)
no annotation 4 LEU A 439
ILE A 480
CYH A 494
PHE A 492
None
0.91A 3ko0S-5xgeA:
undetectable
3ko0S-5xgeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor)
no annotation 4 LEU A 159
SER A 161
ILE A 153
PHE A 316
None
0.70A 3ko0S-5z0cA:
undetectable
3ko0S-5z0cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S


(Oryctolagus
cuniculus)
no annotation 4 LEU A 471
SER A 473
PHE A 475
ILE A 441
None
0.95A 3ko0S-6byoA:
0.0
3ko0S-6byoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1


(Homo sapiens)
no annotation 4 LEU A 431
SER A 433
PHE A 434
ILE A 780
None
1.02A 3ko0S-6d4jA:
undetectable
3ko0S-6d4jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT


(Influenza A
virus)
no annotation 4 LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
0.90A 3ko0S-6evjB:
undetectable
3ko0S-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1


(Homo sapiens)
no annotation 4 LEU A 682
PHE A 668
ILE A 626
CYH A 649
None
1.01A 3ko0S-6f9nA:
undetectable
3ko0S-6f9nA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2y PROTEIN (LUMAZINE
SYNTHASE)


(Spinacia
oleracea)
PF00885
(DMRL_synthase)
3 GLU A  33
LEU A  36
ASP A  37
None
0.32A 3ko0T-1c2yA:
undetectable
3ko0T-1c2yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
3 GLU A 294
LEU A 291
ASP A 290
None
0.39A 3ko0T-1kczA:
undetectable
3ko0T-1kczA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1j HEAT SHOCK PROTEASE
HTRA


(Thermotoga
maritima)
PF13365
(Trypsin_2)
3 GLU A 125
LEU A 126
ASP A 127
None
0.42A 3ko0T-1l1jA:
undetectable
3ko0T-1l1jA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
3 GLU A 343
LEU A 346
ASP A 347
None
0.14A 3ko0T-1obbA:
undetectable
3ko0T-1obbA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT


(Homo sapiens)
PF08785
(Ku_PK_bind)
3 GLU A  63
LEU A  66
ASP A  67
None
0.25A 3ko0T-1rw2A:
undetectable
3ko0T-1rw2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1


(Homo sapiens)
PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind)
3 GLU A 163
LEU A 166
ASP A 167
None
0.39A 3ko0T-1tdhA:
undetectable
3ko0T-1tdhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjk MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1


(Pyrococcus
furiosus)
PF02597
(ThiS)
3 GLU A  37
LEU A  34
ASP A  33
None
0.43A 3ko0T-1vjkA:
undetectable
3ko0T-1vjkA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699


(Agrobacterium
fabrum)
PF04073
(tRNA_edit)
3 GLU A  67
LEU A 127
ASP A 126
None
0.40A 3ko0T-1vkiA:
undetectable
3ko0T-1vkiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgn UBIQUITIN ASSOCIATED
PROTEIN


(Homo sapiens)
no annotation 3 GLU A  48
LEU A  51
ASP A  52
None
0.18A 3ko0T-1wgnA:
undetectable
3ko0T-1wgnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9u UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Homo sapiens)
PF08969
(USP8_dimer)
3 GLU A  49
LEU A  52
ASP A  53
None
0.30A 3ko0T-2a9uA:
undetectable
3ko0T-2a9uA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR


(Sus scrofa)
PF13516
(LRR_6)
3 GLU A 130
LEU A 133
ASP A 134
None
0.26A 3ko0T-2bnhA:
undetectable
3ko0T-2bnhA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2s EXOCYST COMPLEX
COMPONENT EXO84


(Saccharomyces
cerevisiae)
PF16528
(Exo84_C)
3 GLU A 557
LEU A 560
ASP A 561
None
0.39A 3ko0T-2d2sA:
undetectable
3ko0T-2d2sA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 GLU A 112
LEU A 115
ASP A 116
None
0.41A 3ko0T-2dzdA:
undetectable
3ko0T-2dzdA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE


(Thermus
thermophilus)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
3 GLU A 329
LEU A 332
ASP A 333
None
0.21A 3ko0T-2e9fA:
0.8
3ko0T-2e9fA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK


(Escherichia
coli)
PF01041
(DegT_DnrJ_EryC1)
3 GLU A 278
LEU A 281
ASP A 282
None
0.37A 3ko0T-2gmuA:
undetectable
3ko0T-2gmuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i10 PUTATIVE TETR
TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF00440
(TetR_N)
3 GLU A  58
LEU A  61
ASP A  62
None
0.42A 3ko0T-2i10A:
undetectable
3ko0T-2i10A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1d DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1


(Homo sapiens)
PF02181
(FH2)
3 GLU G 746
LEU G 743
ASP G 742
None
0.40A 3ko0T-2j1dG:
undetectable
3ko0T-2j1dG:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE


(Acanthamoeba
polyphaga
mimivirus)
PF00579
(tRNA-synt_1b)
3 GLU A 125
LEU A 128
ASP A 129
GLU  A 125 ( 0.6A)
LEU  A 128 ( 0.6A)
ASP  A 129 ( 0.6A)
0.24A 3ko0T-2j5bA:
undetectable
3ko0T-2j5bA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khz C-MYC-RESPONSIVE
PROTEIN RCL


(Rattus
norvegicus)
PF05014
(Nuc_deoxyrib_tr)
3 GLU A 140
LEU A 143
ASP A 144
None
0.40A 3ko0T-2khzA:
undetectable
3ko0T-2khzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6c THIOREDOXIN

(Desulfovibrio
vulgaris)
PF00085
(Thioredoxin)
3 GLU A  38
LEU A  41
ASP A  42
None
0.34A 3ko0T-2l6cA:
undetectable
3ko0T-2l6cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lse FOUR HELIX BUNDLE
PROTEIN


(synthetic
construct)
no annotation 3 GLU A  13
LEU A  16
ASP A  17
None
0.40A 3ko0T-2lseA:
undetectable
3ko0T-2lseA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mn2 YMOB

(Yersinia
enterocolitica)
PF10757
(YbaJ)
3 GLU A  77
LEU A  80
ASP A  81
None
0.42A 3ko0T-2mn2A:
undetectable
3ko0T-2mn2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha)
PF07859
(Abhydrolase_3)
3 GLU A 232
LEU A 229
ASP A 228
None
0.40A 3ko0T-2o7rA:
undetectable
3ko0T-2o7rA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT


(Exiguobacterium
sibiricum)
PF02655
(ATP-grasp_3)
3 GLU A 239
LEU A 242
ASP A 243
None
0.43A 3ko0T-2pn1A:
undetectable
3ko0T-2pn1A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME


(Burkholderia
pseudomallei)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 GLU A 160
LEU A 163
ASP A 164
None
0.31A 3ko0T-2podA:
undetectable
3ko0T-2podA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN


(Rhodococcus
jostii)
PF00440
(TetR_N)
3 GLU A 172
LEU A 175
ASP A 176
None
0.30A 3ko0T-2raeA:
undetectable
3ko0T-2raeA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1


(Homo sapiens)
PF00076
(RRM_1)
3 GLU A 459
LEU A 462
ASP A 463
None
0.34A 3ko0T-2rvjA:
undetectable
3ko0T-2rvjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tmk THYMIDYLATE KINASE

(Saccharomyces
cerevisiae)
PF02223
(Thymidylate_kin)
3 GLU A 171
LEU A 168
ASP A 169
None
0.44A 3ko0T-2tmkA:
undetectable
3ko0T-2tmkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT


(Bacillus phage
SPP1)
PF17288
(Terminase_3C)
3 GLU A 354
LEU A 357
ASP A 358
None
0.13A 3ko0T-2wbnA:
undetectable
3ko0T-2wbnA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE


(Rhodobacter
sphaeroides)
PF13561
(adh_short_C2)
3 GLU A 208
LEU A 211
ASP A 212
None
0.43A 3ko0T-2wsbA:
undetectable
3ko0T-2wsbA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh3 SPD1 NUCLEASE

(Streptococcus
pyogenes)
PF13930
(Endonuclea_NS_2)
3 GLU A 164
LEU A 167
ASP A 168
None
0.20A 3ko0T-2xh3A:
undetectable
3ko0T-2xh3A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7e NIFU-LIKE PROTEIN

(Aquifex
aeolicus)
PF01592
(NifU_N)
3 GLU A   7
LEU A  10
ASP A  11
None
0.24A 3ko0T-2z7eA:
undetectable
3ko0T-2z7eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc4 PENICILLIN-BINDING
PROTEIN 2X


(Streptococcus
pneumoniae)
PF03793
(PASTA)
3 GLU C 652
LEU C 649
ASP C 648
None
0.43A 3ko0T-2zc4C:
undetectable
3ko0T-2zc4C:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE


(Escherichia
coli)
PF05958
(tRNA_U5-meth_tr)
3 GLU A 201
LEU A 204
ASP A 205
None
0.25A 3ko0T-3bt7A:
undetectable
3ko0T-3bt7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c90 PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE


(Mycobacterium
tuberculosis)
no annotation 3 GLU X  16
LEU X  13
ASP X  12
None
0.38A 3ko0T-3c90X:
undetectable
3ko0T-3c90X:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crl DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL


(Homo sapiens)
PF00364
(Biotin_lipoyl)
3 GLU C 179
LEU C 165
ASP C 164
None
0.41A 3ko0T-3crlC:
undetectable
3ko0T-3crlC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA


(Candida
albicans)
PF01239
(PPTA)
3 GLU A  94
LEU A  97
ASP A  98
None
0.20A 3ko0T-3draA:
undetectable
3ko0T-3draA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC


(Oryza sativa)
no annotation 3 GLU O 139
LEU O 329
ASP O 328
None
0.41A 3ko0T-3e6aO:
undetectable
3ko0T-3e6aO:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoo METHYLISOCITRATE
LYASE


(Burkholderia
pseudomallei)
PF13714
(PEP_mutase)
3 GLU A 285
LEU A 288
ASP A 289
None
0.41A 3ko0T-3eooA:
undetectable
3ko0T-3eooA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd9 UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF16806
(ExsD)
3 GLU A 132
LEU A 135
ASP A 136
None
0.35A 3ko0T-3fd9A:
undetectable
3ko0T-3fd9A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6i PUTATIVE OUTER
MEMBRANE PROTEIN,
PART OF CARBOHYDRATE
BINDING COMPLEX


(Bacteroides
thetaiotaomicron)
PF12875
(DUF3826)
3 GLU A 145
LEU A 148
ASP A 149
None
0.19A 3ko0T-3g6iA:
undetectable
3ko0T-3g6iA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE


(Marinobacter
hydrocarbonoclasticus)
PF00365
(PFK)
3 GLU A 169
LEU A 172
ASP A 173
None
0.23A 3ko0T-3k2qA:
0.6
3ko0T-3k2qA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE


(Pimelobacter
simplex)
PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2)
3 GLU A 215
LEU A 218
ASP A 219
None
0.24A 3ko0T-3k30A:
undetectable
3ko0T-3k30A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7x LIN0763 PROTEIN

(Listeria
innocua)
PF03663
(Glyco_hydro_76)
3 GLU A 281
LEU A 278
ASP A 277
None
0.42A 3ko0T-3k7xA:
undetectable
3ko0T-3k7xA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.)
PF00557
(Peptidase_M24)
3 GLU A 294
LEU A 297
ASP A 298
None
0.33A 3ko0T-3l7gA:
undetectable
3ko0T-3l7gA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgj UNCHARACTERIZED
PROTEIN MJ1480


(Methanocaldococcus
jannaschii)
PF04455
(Saccharop_dh_N)
3 GLU A  74
LEU A  71
ASP A  70
None
0.38A 3ko0T-3mgjA:
undetectable
3ko0T-3mgjA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og4 INTERLEUKIN-29

(Homo sapiens)
PF15177
(IL28A)
3 GLU A  92
LEU A  95
ASP A  96
None
0.41A 3ko0T-3og4A:
undetectable
3ko0T-3og4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Burkholderia
pseudomallei)
PF00155
(Aminotran_1_2)
3 GLU A 237
LEU A 240
ASP A 241
None
0.37A 3ko0T-3p1tA:
undetectable
3ko0T-3p1tA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
mutans)
PF02645
(DegV)
3 GLU A 150
LEU A 153
ASP A 154
None
0.22A 3ko0T-3pl5A:
undetectable
3ko0T-3pl5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Francisella
tularensis)
PF00342
(PGI)
3 GLU A 215
LEU A 218
ASP A 219
None
0.43A 3ko0T-3q88A:
0.6
3ko0T-3q88A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF06824
(Glyco_hydro_125)
3 GLU A 417
LEU A 420
ASP A 421
EDO  A 433 ( 4.4A)
EDO  A 435 ( 4.5A)
None
0.31A 3ko0T-3qpfA:
undetectable
3ko0T-3qpfA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzy BACULOVIRUS
SULFHYDRYL OXIDASE
AC92


(Autographa
californica
multiple
nucleopolyhedrovirus)
PF05214
(Baculo_p33)
3 GLU A 177
LEU A 180
ASP A 181
None
0.34A 3ko0T-3qzyA:
1.8
3ko0T-3qzyA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE


(Mycobacterium
marinum)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
3 GLU A  76
LEU A  79
ASP A  80
None
0.13A 3ko0T-3rv2A:
undetectable
3ko0T-3rv2A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shr CGMP-DEPENDENT
PROTEIN KINASE 1


(Bos taurus)
PF00027
(cNMP_binding)
3 GLU A  95
LEU A  98
ASP A  99
None
0.31A 3ko0T-3shrA:
undetectable
3ko0T-3shrA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Sulfitobacter
sp. NAS-14.1)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 GLU A 151
LEU A 154
ASP A 155
None
0.31A 3ko0T-3t4wA:
undetectable
3ko0T-3t4wA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
3 GLU A  19
LEU A  22
ASP A  23
None
0.26A 3ko0T-3ts7A:
undetectable
3ko0T-3ts7A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE


(Streptomyces
lavendulae)
PF00561
(Abhydrolase_1)
3 GLU A 258
LEU A 261
ASP A 262
None
0.22A 3ko0T-3vvlA:
undetectable
3ko0T-3vvlA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Gluconobacter
oxydans)
PF00171
(Aldedh)
3 GLU A 313
LEU A 316
ASP A 317
None
0.41A 3ko0T-3vz0A:
undetectable
3ko0T-3vz0A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzp RIBOSOMAL PROTEIN S6

(Thermus
thermophilus)
no annotation 3 GLU A  25
LEU A  22
ASP A  21
None
0.43A 3ko0T-3zzpA:
undetectable
3ko0T-3zzpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ack TSSL

(Francisella
tularensis)
PF09850
(DotU)
3 GLU A   8
LEU A  11
ASP A  12
None
None
BR  A1156 ( 4.4A)
0.37A 3ko0T-4ackA:
undetectable
3ko0T-4ackA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am2 BACTERIOFERRITIN

(Blastochloris
viridis)
PF00210
(Ferritin)
3 GLU A 135
LEU A 138
ASP A 139
None
0.29A 3ko0T-4am2A:
undetectable
3ko0T-4am2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axz PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi)
PF05714
(Borrelia_lipo_1)
3 GLU A 270
LEU A 271
ASP A 272
None
0.39A 3ko0T-4axzA:
0.9
3ko0T-4axzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e44 CENTROMERE PROTEIN S

(Homo sapiens)
PF15630
(CENP-S)
3 GLU A  33
LEU A  36
ASP A  37
None
0.43A 3ko0T-4e44A:
undetectable
3ko0T-4e44A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium)
PF00150
(Cellulase)
3 GLU A 253
LEU A 256
ASP A 257
None
0.34A 3ko0T-4ee9A:
undetectable
3ko0T-4ee9A:
12.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eto PROTEIN S100-A4

(Homo sapiens)
PF01023
(S_100)
3 GLU A   6
LEU A   9
ASP A  10
None
0.35A 3ko0T-4etoA:
16.6
3ko0T-4etoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd6 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
2


(Aedes aegypti)
PF00583
(Acetyltransf_1)
3 GLU A 157
LEU A 160
ASP A 161
None
0.26A 3ko0T-4fd6A:
undetectable
3ko0T-4fd6A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes)
PF07537
(CamS)
3 GLU A 110
LEU A 113
ASP A 114
None
0.20A 3ko0T-4hn3A:
undetectable
3ko0T-4hn3A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA


(Homo sapiens)
PF13499
(EF-hand_7)
3 GLU A 438
LEU A 441
ASP A 442
None
0.34A 3ko0T-4i5jA:
2.6
3ko0T-4i5jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC


(Pyrococcus
furiosus)
PF02463
(SMC_N)
3 GLU A1117
LEU A1114
ASP A1113
None
0.37A 3ko0T-4i99A:
undetectable
3ko0T-4i99A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Mycobacterium
tuberculosis)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
3 GLU A 266
LEU A 269
ASP A 270
None
0.28A 3ko0T-4kbmA:
undetectable
3ko0T-4kbmA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne5 CENTROMERE PROTEIN S

(Homo sapiens)
PF15630
(CENP-S)
3 GLU A  33
LEU A  36
ASP A  37
None
0.33A 3ko0T-4ne5A:
undetectable
3ko0T-4ne5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN


(Escherichia
coli)
no annotation 3 GLU B 193
LEU B 196
ASP B 197
None
0.34A 3ko0T-4pl2B:
undetectable
3ko0T-4pl2B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE


(Salmonella
enterica)
PF00248
(Aldo_ket_red)
3 GLU A  39
LEU A  42
ASP A  43
None
0.21A 3ko0T-4r9oA:
undetectable
3ko0T-4r9oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA


(Bacillus
subtilis)
PF11638
(DnaA_N)
3 GLU B   2
LEU B   5
ASP B   6
None
0.34A 3ko0T-4tpsB:
undetectable
3ko0T-4tpsB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB


(Mycobacterium
tuberculosis)
no annotation 3 GLU A 185
LEU A 188
ASP A 189
None
0.18A 3ko0T-4xxnA:
undetectable
3ko0T-4xxnA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xy3 ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB


(Mycobacterium
tuberculosis)
no annotation 3 GLU A 185
LEU A 188
ASP A 189
None
0.29A 3ko0T-4xy3A:
undetectable
3ko0T-4xy3A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0h GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
GAPC1, CYTOSOLIC


(Arabidopsis
thaliana)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
3 GLU O 134
LEU O 324
ASP O 323
None
0.36A 3ko0T-4z0hO:
undetectable
3ko0T-4z0hO:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E


(Alteromonas sp.)
PF00557
(Peptidase_M24)
3 GLU A 294
LEU A 297
ASP A 298
None
0.19A 3ko0T-4zwoA:
undetectable
3ko0T-4zwoA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1


(Ovis aries)
PF00171
(Aldedh)
3 GLU A 351
LEU A 354
ASP A 355
None
0.23A 3ko0T-5abmA:
undetectable
3ko0T-5abmA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bux 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ


(Yersinia pestis)
PF07977
(FabA)
3 GLU A  11
LEU A  14
ASP A  15
None
0.41A 3ko0T-5buxA:
undetectable
3ko0T-5buxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE


(Pseudomonas
syringae group
genomosp. 3)
PF13434
(K_oxygenase)
3 GLU A 424
LEU A  42
ASP A  41
None
0.43A 3ko0T-5cqfA:
undetectable
3ko0T-5cqfA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR


(Mycolicibacterium
smegmatis)
PF00440
(TetR_N)
3 GLU A  24
LEU A  27
ASP A  28
None
0.19A 3ko0T-5e57A:
1.0
3ko0T-5e57A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE


(Acinetobacter
baumannii)
PF01218
(Coprogen_oxidas)
3 GLU A  14
LEU A  17
ASP A  18
None
0.19A 3ko0T-5eo6A:
undetectable
3ko0T-5eo6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE


(Symbiobacterium
thermophilum)
PF00282
(Pyridoxal_deC)
3 GLU A 372
LEU A 375
ASP A 376
None
0.22A 3ko0T-5eueA:
undetectable
3ko0T-5eueA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli)
PF04055
(Radical_SAM)
3 GLU A 193
LEU A 196
ASP A 197
None
MG  A 504 (-4.9A)
None
0.40A 3ko0T-5hr6A:
undetectable
3ko0T-5hr6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itq ENDONUCLEASE 8-LIKE
1


(Homo sapiens)
PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind)
3 GLU A 163
LEU A 166
ASP A 167
None
0.43A 3ko0T-5itqA:
1.9
3ko0T-5itqA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kht TROPOMYOSIN ALPHA-1
CHAIN,GENERAL
CONTROL PROTEIN GCN4


(Homo sapiens;
Saccharomyces
cerevisiae)
no annotation 3 GLU A  16
LEU A  19
ASP A  20
None
0.14A 3ko0T-5khtA:
undetectable
3ko0T-5khtA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8a PEROXIN 14

(Trypanosoma
brucei)
PF04695
(Pex14_N)
3 GLU A  16
LEU A  19
ASP A  20
6RB  A 101 (-3.7A)
None
6RB  A 101 ( 4.2A)
0.43A 3ko0T-5l8aA:
undetectable
3ko0T-5l8aA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE


(Nocardia
iowensis)
PF00501
(AMP-binding)
3 GLU A 407
LEU A 410
ASP A 411
None
0.37A 3ko0T-5mscA:
undetectable
3ko0T-5mscA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B


(Methanothermococcus
thermolithotrophicus)
PF02754
(CCG)
3 GLU B 206
LEU B 209
ASP B 210
None
0.26A 3ko0T-5odrB:
undetectable
3ko0T-5odrB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)


(Globodera
pallida)
no annotation 3 GLU B  49
LEU B  52
ASP B  53
None
0.23A 3ko0T-5oetB:
undetectable
3ko0T-5oetB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vr3 BRAF

(Homo sapiens)
no annotation 3 GLU A  62
LEU A  65
ASP A  66
None
0.18A 3ko0T-5vr3A:
undetectable
3ko0T-5vr3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF


(Homo sapiens)
no annotation 3 GLU A1062
LEU A1065
ASP A1066
None
0.22A 3ko0T-5vykA:
undetectable
3ko0T-5vykA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC


(Pyrococcus
furiosus)
PF02463
(SMC_N)
3 GLU A1117
LEU A1114
ASP A1113
None
0.39A 3ko0T-5xnsA:
undetectable
3ko0T-5xnsA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
3 GLU B 320
LEU B 323
ASP B 324
None
0.32A 3ko0T-5xogB:
undetectable
3ko0T-5xogB:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xto FAD-LINKED
SULFHYDRYL OXIDASE


(Autographa
californica
multiple
nucleopolyhedrovirus)
PF05214
(Baculo_p33)
3 GLU A 177
LEU A 180
ASP A 181
None
0.40A 3ko0T-5xtoA:
undetectable
3ko0T-5xtoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE


(Glaciozyma
antarctica)
no annotation 3 GLU A 162
LEU A 165
ASP A 166
None
0.23A 3ko0T-5yhpA:
undetectable
3ko0T-5yhpA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER


(Homo sapiens)
no annotation 3 GLU A1813
LEU A1712
ASP A1713
None
0.44A 3ko0T-5zalA:
undetectable
3ko0T-5zalA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea VANADIUM
NITROGENASE, DELTA
SUBUNIT, VNFG


(Azotobacter
vinelandii)
no annotation 3 GLU C  85
LEU C  88
ASP C  89
None
0.39A 3ko0T-6feaC:
undetectable
3ko0T-6feaC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ggp AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Thermotoga
maritima)
no annotation 3 GLU A  60
LEU A  57
ASP A  56
None
0.42A 3ko0T-6ggpA:
undetectable
3ko0T-6ggpA:
23.71