SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_Q_TFPQ201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE

(Azotobacter
vinelandii) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLY A 234
PHE A 235
ILE A 218
PHE A 201
 None
 0.79A 3ko0O-1a8pA:
undetectable
3ko0Q-1a8pA:
undetectable		 3ko0O-1a8pA:
16.99
3ko0Q-1a8pA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu3 CALCIUM-BINDING
PROTEIN

(Merluccius
bilinearis) 		PF13499
(EF-hand_7) 		4 GLY A  89
PHE A  85
PHE A  29
PHE A  24
 None
 0.96A 3ko0O-1bu3A:
5.6
3ko0Q-1bu3A:
4.8		 3ko0O-1bu3A:
18.02
3ko0Q-1bu3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e96 NEUTROPHIL CYTOSOL
FACTOR 2 (NCF-2) TPR
DOMAIN, RESIDUES
1-203

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		5 PHE B 183
GLY B 113
ILE B 177
CYH B  45
PHE B  29
 None
 1.39A 3ko0O-1e96B:
undetectable
3ko0Q-1e96B:
0.0		 3ko0O-1e96B:
17.77
3ko0Q-1e96B:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		4 PHE A 100
PHE A 103
ILE A 128
PHE A 111
 None
 0.97A 3ko0O-1ezfA:
undetectable
3ko0Q-1ezfA:
0.0		 3ko0O-1ezfA:
15.55
3ko0Q-1ezfA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 PHE A 263
GLY A 262
ILE A 296
PHE A 254
 None
 0.96A 3ko0O-1ff9A:
undetectable
3ko0Q-1ff9A:
undetectable		 3ko0O-1ff9A:
15.38
3ko0Q-1ff9A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 PHE A  22
ILE A 155
MET A 154
PHE A  19
 None
 0.90A 3ko0O-1j5xA:
undetectable
3ko0Q-1j5xA:
0.1		 3ko0O-1j5xA:
15.98
3ko0Q-1j5xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 PHE A 182
GLY A  66
ILE A  42
PHE A 205
 None
 0.99A 3ko0O-1kijA:
undetectable
3ko0Q-1kijA:
undetectable		 3ko0O-1kijA:
14.52
3ko0Q-1kijA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLY A 242
PHE A 241
ILE A 225
PHE A 184
 None
 0.84A 3ko0O-1kkhA:
undetectable
3ko0Q-1kkhA:
0.5		 3ko0O-1kkhA:
17.39
3ko0Q-1kkhA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6u NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		5 PHE A 114
GLY A  98
PHE A  99
ILE A 157
PHE A 273
 None
SO4  A 400 (-3.1A)
None
None
None
 1.29A 3ko0O-1m6uA:
undetectable
3ko0Q-1m6uA:
undetectable		 3ko0O-1m6uA:
16.09
3ko0Q-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		5 PHE A 114
GLY A  98
PHE A  99
ILE A 157
PHE A 273
 None
 1.34A 3ko0O-1mnnA:
undetectable
3ko0Q-1mnnA:
undetectable		 3ko0O-1mnnA:
14.95
3ko0Q-1mnnA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 151
PHE A 150
ILE A  82
CYH A 103
 None
 0.88A 3ko0O-1muuA:
undetectable
3ko0Q-1muuA:
undetectable		 3ko0O-1muuA:
13.98
3ko0Q-1muuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 481
PHE A 476
ILE A 719
PHE A 469
 None
 0.91A 3ko0O-1naaA:
0.4
3ko0Q-1naaA:
undetectable		 3ko0O-1naaA:
9.94
3ko0Q-1naaA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhy ELONGATION FACTOR
1-GAMMA 1

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PHE A 177
GLY A 178
ILE A 115
PHE A 208
 None
 0.96A 3ko0O-1nhyA:
undetectable
3ko0Q-1nhyA:
0.0		 3ko0O-1nhyA:
19.18
3ko0Q-1nhyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oru YUAD PROTEIN

(Bacillus
subtilis) 		no annotation 4 PHE A  30
GLY A 168
ILE A 112
CYH A 162
 None
 0.94A 3ko0O-1oruA:
undetectable
3ko0Q-1oruA:
0.0		 3ko0O-1oruA:
19.58
3ko0Q-1oruA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		4 GLY A 453
PHE A 487
MET A 471
PHE A 542
 None
 0.96A 3ko0O-1qjmA:
undetectable
3ko0Q-1qjmA:
0.0		 3ko0O-1qjmA:
10.40
3ko0Q-1qjmA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 GLY A 305
ILE A 297
CYH A 295
PHE A 294
 None
 0.90A 3ko0O-1rzvA:
undetectable
3ko0Q-1rzvA:
undetectable		 3ko0O-1rzvA:
12.61
3ko0Q-1rzvA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s40 CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF02765
(POT1) 		5 GLY A  79
PHE A  80
ILE A 120
CYH A 122
PHE A  31
 None
 1.49A 3ko0O-1s40A:
undetectable
3ko0Q-1s40A:
undetectable		 3ko0O-1s40A:
21.32
3ko0Q-1s40A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		5 PHE A  18
GLY A 209
PHE A 210
ILE A 143
PHE A 242
 None
 1.21A 3ko0O-1t47A:
undetectable
3ko0Q-1t47A:
undetectable		 3ko0O-1t47A:
15.34
3ko0Q-1t47A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t84 WISKOTT-ALDRICH
SYNDROME PROTEIN

(Homo sapiens) 		PF00786
(PBD) 		4 GLY A  16
PHE A  17
PHE A  52
PHE A  30
 None
WSK  A 108 (-3.7A)
None
None
 0.93A 3ko0O-1t84A:
undetectable
3ko0Q-1t84A:
undetectable		 3ko0O-1t84A:
23.01
3ko0Q-1t84A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 PHE A 287
PHE A 282
ILE A 255
PHE A  81
 None
 0.93A 3ko0O-1vmaA:
2.4
3ko0Q-1vmaA:
2.5		 3ko0O-1vmaA:
14.05
3ko0Q-1vmaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 406
GLY A 403
ILE A 504
PHE A 483
 None
 0.98A 3ko0O-1y9gA:
undetectable
3ko0Q-1y9gA:
undetectable		 3ko0O-1y9gA:
12.19
3ko0Q-1y9gA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 PHE A  60
GLY A   4
PHE A   5
ILE A 151
 None
 0.93A 3ko0O-1yb4A:
undetectable
3ko0Q-1yb4A:
undetectable		 3ko0O-1yb4A:
18.12
3ko0Q-1yb4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLY A  90
PHE A  89
MET A 130
PHE A 120
 None
 0.84A 3ko0O-1zybA:
undetectable
3ko0Q-1zybA:
undetectable		 3ko0O-1zybA:
16.67
3ko0Q-1zybA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Homo sapiens) 		PF01424
(R3H)
PF04857
(CAF1) 		4 PHE A 400
GLY A 398
ILE A 337
PHE A 418
 None
 0.78A 3ko0O-2a1rA:
undetectable
3ko0Q-2a1rA:
undetectable		 3ko0O-2a1rA:
13.08
3ko0Q-2a1rA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268

(Pseudomonas
aeruginosa) 		PF05544
(Pro_racemase) 		4 GLY A  22
PHE A  23
ILE A   7
PHE A  79
 None
 0.94A 3ko0O-2azpA:
undetectable
3ko0Q-2azpA:
undetectable		 3ko0O-2azpA:
14.24
3ko0Q-2azpA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		4 GLY A 174
PHE A 240
CYH A  69
PHE A  71
 None
 0.83A 3ko0O-2bbvA:
undetectable
3ko0Q-2bbvA:
undetectable		 3ko0O-2bbvA:
12.11
3ko0Q-2bbvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 GLY A 110
PHE A 111
ILE A 103
PHE A 120
 None
IH4  A1330 (-3.4A)
None
None
 0.98A 3ko0O-2bjuA:
undetectable
3ko0Q-2bjuA:
undetectable		 3ko0O-2bjuA:
12.86
3ko0Q-2bjuA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp3 FILAMIN A

(Homo sapiens) 		PF00630
(Filamin) 		4 PHE A1886
GLY A1874
ILE A1910
CYH A1912
 None
 0.91A 3ko0O-2bp3A:
undetectable
3ko0Q-2bp3A:
undetectable		 3ko0O-2bp3A:
22.22
3ko0Q-2bp3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE

(Escherichia
coli) 		PF02734
(Dak2) 		4 GLY A  16
PHE A  46
ILE A  64
PHE A  87
 None
 0.91A 3ko0O-2btdA:
undetectable
3ko0Q-2btdA:
undetectable		 3ko0O-2btdA:
19.43
3ko0Q-2btdA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed2 GENERAL
TRANSCRIPTION FACTOR
II-I

(Homo sapiens) 		PF02946
(GTF2I) 		4 PHE A  55
CYH A  17
PHE A  20
PHE A  78
 None
 0.97A 3ko0O-2ed2A:
undetectable
3ko0Q-2ed2A:
undetectable		 3ko0O-2ed2A:
19.83
3ko0Q-2ed2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 120
PHE A 121
ILE A  55
PHE A 326
 None
 0.94A 3ko0O-2ejvA:
undetectable
3ko0Q-2ejvA:
undetectable		 3ko0O-2ejvA:
13.37
3ko0Q-2ejvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 GLY A 288
ILE A 274
CYH A 306
PHE A  19
 None
 0.93A 3ko0O-2i2xA:
undetectable
3ko0Q-2i2xA:
undetectable		 3ko0O-2i2xA:
13.19
3ko0Q-2i2xA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 GLY A 300
ILE A 274
CYH A 306
PHE A  19
 None
 0.96A 3ko0O-2i2xA:
undetectable
3ko0Q-2i2xA:
undetectable		 3ko0O-2i2xA:
13.19
3ko0Q-2i2xA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLY A 303
PHE A 291
ILE A 265
PHE A 113
 None
 0.95A 3ko0O-2ifyA:
undetectable
3ko0Q-2ifyA:
undetectable		 3ko0O-2ifyA:
10.94
3ko0Q-2ifyA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuc ALKALINE PHOSPHATASE

(Antarctic
bacterium TAB5) 		PF00245
(Alk_phosphatase) 		4 PHE B 307
GLY B 306
PHE B 332
ILE B 328
 None
 0.98A 3ko0O-2iucB:
undetectable
3ko0Q-2iucB:
undetectable		 3ko0O-2iucB:
13.71
3ko0Q-2iucB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzc UDP-N-ACETYLGLUCOSAM
INE TRANSFERASE
SUBUNIT ALG13

(Saccharomyces
cerevisiae) 		PF04101
(Glyco_tran_28_C) 		4 GLY A  36
PHE A  69
ILE A  66
PHE A  77
 None
 0.99A 3ko0O-2jzcA:
undetectable
3ko0Q-2jzcA:
undetectable		 3ko0O-2jzcA:
20.64
3ko0Q-2jzcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2

(Homo sapiens) 		PF02174
(IRS) 		4 GLY A  83
PHE A  87
ILE A  46
MET A  38
 None
 0.92A 3ko0O-2mfqA:
undetectable
3ko0Q-2mfqA:
undetectable		 3ko0O-2mfqA:
20.97
3ko0Q-2mfqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		4 PHE A 371
PHE A 341
ILE A 330
PHE A 379
 None
 0.91A 3ko0O-2o5rA:
undetectable
3ko0Q-2o5rA:
undetectable		 3ko0O-2o5rA:
12.33
3ko0Q-2o5rA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 GLY A  88
MET A  98
CYH A  97
PHE A 142
 SAH  A 301 (-3.1A)
None
None
None
 0.88A 3ko0O-2pbfA:
undetectable
3ko0Q-2pbfA:
undetectable		 3ko0O-2pbfA:
16.37
3ko0Q-2pbfA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 PHE B 204
GLY B  62
ILE B 178
PHE B  70
 None
None
None
ADP  B   9 (-4.2A)
 0.94A 3ko0O-2qbyB:
undetectable
3ko0Q-2qbyB:
1.8		 3ko0O-2qbyB:
14.53
3ko0Q-2qbyB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt5 GLUTAMATE
RECEPTOR-INTERACTING
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 PHE A 162
GLY A 163
PHE A 164
MET A 220
 EDO  A   1 (-4.9A)
None
EDO  A   1 (-4.3A)
EDO  A   1 (-3.6A)
 0.95A 3ko0O-2qt5A:
undetectable
3ko0Q-2qt5A:
undetectable		 3ko0O-2qt5A:
19.00
3ko0Q-2qt5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		PF00500
(Late_protein_L1) 		4 GLY A 160
PHE A 328
ILE A 165
PHE A 446
 None
 0.96A 3ko0O-2r5jA:
undetectable
3ko0Q-2r5jA:
undetectable		 3ko0O-2r5jA:
13.43
3ko0Q-2r5jA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyd HEMOPHORE HASA

(Serratia
marcescens) 		PF06438
(HasA) 		5 PHE X  11
GLY X  12
PHE X 166
PHE X  94
PHE X 115
 None
 1.28A 3ko0O-2uydX:
undetectable
3ko0Q-2uydX:
0.7		 3ko0O-2uydX:
16.13
3ko0Q-2uydX:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 GLY A 252
PHE A 253
ILE A 216
PHE A 211
 None
 0.98A 3ko0O-2vcaA:
undetectable
3ko0Q-2vcaA:
undetectable		 3ko0O-2vcaA:
8.00
3ko0Q-2vcaA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wor PROTEIN S100-A7

(Homo sapiens) 		PF01023
(S_100) 		4 GLY A  79
ILE A   9
MET A  12
PHE A  16
 None
None
2AN  A1098 ( 3.8A)
None
 0.70A 3ko0O-2worA:
11.3
3ko0Q-2worA:
11.8		 3ko0O-2worA:
25.71
3ko0Q-2worA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A   9
GLY A  13
ILE A  84
CYH A  86
 None
 0.97A 3ko0O-2x0nA:
undetectable
3ko0Q-2x0nA:
undetectable		 3ko0O-2x0nA:
14.48
3ko0Q-2x0nA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PHE A 434
GLY A 433
PHE A 113
PHE A 109
 None
 0.98A 3ko0O-2yfhA:
0.3
3ko0Q-2yfhA:
undetectable		 3ko0O-2yfhA:
12.47
3ko0Q-2yfhA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 PHE A 187
GLY A   8
PHE A   7
ILE A 400
PHE A 147
 None
 1.48A 3ko0O-2zwsA:
undetectable
3ko0Q-2zwsA:
undetectable		 3ko0O-2zwsA:
9.49
3ko0Q-2zwsA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A 248
GLY A 249
ILE A 218
PHE A 242
 None
 0.96A 3ko0O-3b96A:
undetectable
3ko0Q-3b96A:
undetectable		 3ko0O-3b96A:
12.27
3ko0Q-3b96A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 GLY A 292
PHE A 293
ILE A 297
PHE A 570
 None
 0.93A 3ko0O-3djaA:
undetectable
3ko0Q-3djaA:
undetectable		 3ko0O-3djaA:
11.59
3ko0Q-3djaA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 GLY A 292
PHE A 293
ILE A 367
PHE A 570
 None
 0.97A 3ko0O-3djaA:
undetectable
3ko0Q-3djaA:
undetectable		 3ko0O-3djaA:
11.59
3ko0Q-3djaA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		4 GLY A 143
ILE A 188
CYH A 213
PHE A 214
 None
 0.84A 3ko0O-3dl1A:
undetectable
3ko0Q-3dl1A:
undetectable		 3ko0O-3dl1A:
15.53
3ko0Q-3dl1A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		4 GLY A 247
PHE A 199
ILE A 217
CYH A 195
 None
 0.89A 3ko0O-3efbA:
undetectable
3ko0Q-3efbA:
undetectable		 3ko0O-3efbA:
19.17
3ko0Q-3efbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		5 PHE X 198
GLY X 220
PHE X 183
ILE X 151
PHE X 179
 None
 1.38A 3ko0O-3ewbX:
undetectable
3ko0Q-3ewbX:
undetectable		 3ko0O-3ewbX:
15.28
3ko0Q-3ewbX:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3

(Campylobacter
jejuni) 		PF13531
(SBP_bac_11) 		4 PHE A  71
GLY A  72
PHE A 215
PHE A 243
 None
 0.88A 3ko0O-3fj7A:
undetectable
3ko0Q-3fj7A:
undetectable		 3ko0O-3fj7A:
18.80
3ko0Q-3fj7A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 PHE A 181
GLY A 182
PHE A 183
PHE A 194
 None
 0.94A 3ko0O-3focA:
undetectable
3ko0Q-3focA:
undetectable		 3ko0O-3focA:
12.28
3ko0Q-3focA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		4 PHE A 323
ILE A 335
PHE A 344
PHE A  85
 None
 0.74A 3ko0O-3h1wA:
undetectable
3ko0Q-3h1wA:
undetectable		 3ko0O-3h1wA:
12.28
3ko0Q-3h1wA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		4 PHE A 259
GLY A 262
PHE A 266
PHE A 336
 None
 0.95A 3ko0O-3h2yA:
undetectable
3ko0Q-3h2yA:
undetectable		 3ko0O-3h2yA:
13.39
3ko0Q-3h2yA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4q PUTATIVE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00583
(Acetyltransf_1) 		4 GLY A  62
PHE A  63
ILE A  89
PHE A  42
 None
 0.85A 3ko0O-3h4qA:
undetectable
3ko0Q-3h4qA:
undetectable		 3ko0O-3h4qA:
16.40
3ko0Q-3h4qA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN

(Bacillus cereus) 		PF06838
(Met_gamma_lyase) 		4 GLY A 396
ILE A 405
CYH A 408
PHE A 337
 None
 0.96A 3ko0O-3ht4A:
0.0
3ko0Q-3ht4A:
0.8		 3ko0O-3ht4A:
12.23
3ko0Q-3ht4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE

(Cryptosporidium
parvum) 		PF00579
(tRNA-synt_1b) 		4 GLY A 385
PHE A 386
ILE A 375
PHE A 397
 None
 0.68A 3ko0O-3hv0A:
undetectable
3ko0Q-3hv0A:
undetectable		 3ko0O-3hv0A:
14.40
3ko0Q-3hv0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv0 TRYPTOPHANYL-TRNA
SYNTHETASE

(Cryptosporidium
parvum) 		PF00579
(tRNA-synt_1b) 		4 PHE A 384
GLY A 385
PHE A 386
ILE A 375
 None
 0.92A 3ko0O-3hv0A:
undetectable
3ko0Q-3hv0A:
undetectable		 3ko0O-3hv0A:
14.40
3ko0Q-3hv0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A

(Homo sapiens) 		PF13419
(HAD_2) 		4 PHE A 130
MET A  15
PHE A  13
PHE A 134
 None
 0.89A 3ko0O-3l5kA:
undetectable
3ko0Q-3l5kA:
undetectable		 3ko0O-3l5kA:
18.44
3ko0Q-3l5kA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 GLY A 306
PHE A 307
ILE A 296
PHE A 353
 None
 0.96A 3ko0O-3lm3A:
undetectable
3ko0Q-3lm3A:
undetectable		 3ko0O-3lm3A:
12.25
3ko0Q-3lm3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY X 154
PHE X 155
ILE X  96
CYH X  94
 None
 0.81A 3ko0O-3nepX:
undetectable
3ko0Q-3nepX:
undetectable		 3ko0O-3nepX:
13.10
3ko0Q-3nepX:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		4 GLY A 139
ILE A 120
MET A 123
CYH A 124
 None
 0.55A 3ko0O-3ovgA:
undetectable
3ko0Q-3ovgA:
undetectable		 3ko0O-3ovgA:
16.57
3ko0Q-3ovgA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		4 GLY A  92
PHE A  93
ILE A  78
CYH A  38
 None
 0.85A 3ko0O-3qdnA:
undetectable
3ko0Q-3qdnA:
undetectable		 3ko0O-3qdnA:
16.67
3ko0Q-3qdnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 PHE L 437
GLY L 367
ILE L 304
PHE L 430
 None
 0.86A 3ko0O-3rkoL:
undetectable
3ko0Q-3rkoL:
0.9		 3ko0O-3rkoL:
8.96
3ko0Q-3rkoL:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 GLY L 224
PHE L 180
ILE L 187
PHE M 427
 None
 0.89A 3ko0O-3rkoL:
undetectable
3ko0Q-3rkoL:
0.9		 3ko0O-3rkoL:
8.96
3ko0Q-3rkoL:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 PHE B  16
CYH B  65
PHE B  68
PHE B  90
 None
 0.92A 3ko0O-3t5vB:
undetectable
3ko0Q-3t5vB:
undetectable		 3ko0O-3t5vB:
13.08
3ko0Q-3t5vB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc9 HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 PHE A 440
GLY A 454
ILE A 393
PHE A 425
 EDO  A 490 (-4.9A)
None
None
None
 0.97A 3ko0O-3tc9A:
undetectable
3ko0Q-3tc9A:
undetectable		 3ko0O-3tc9A:
11.74
3ko0Q-3tc9A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 PHE A  34
GLY A  30
ILE A 268
CYH A 240
 None
 0.93A 3ko0O-3ufgA:
undetectable
3ko0Q-3ufgA:
undetectable		 3ko0O-3ufgA:
15.08
3ko0Q-3ufgA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 325
GLY A 323
PHE A 322
ILE A 343
 None
 0.91A 3ko0O-3ukoA:
undetectable
3ko0Q-3ukoA:
undetectable		 3ko0O-3ukoA:
15.34
3ko0Q-3ukoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 GLY A 656
ILE A 673
CYH A 623
PHE A 660
 None
 0.81A 3ko0O-3v9fA:
undetectable
3ko0Q-3v9fA:
undetectable		 3ko0O-3v9fA:
9.27
3ko0Q-3v9fA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zth STU0660

(Streptococcus
thermophilus) 		PF16813
(Cas_St_Csn2) 		4 PHE A  83
PHE A 172
ILE A 178
PHE A 184
 None
 0.87A 3ko0O-3zthA:
undetectable
3ko0Q-3zthA:
undetectable		 3ko0O-3zthA:
15.71
3ko0Q-3zthA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 PHE A 120
PHE A 268
ILE A 197
PHE A 277
 None
 0.97A 3ko0O-4cfhA:
undetectable
3ko0Q-4cfhA:
undetectable		 3ko0O-4cfhA:
11.83
3ko0Q-4cfhA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 GLY A  72
PHE A 229
ILE A 212
MET A 208
 None
 0.92A 3ko0O-4e2pA:
undetectable
3ko0Q-4e2pA:
undetectable		 3ko0O-4e2pA:
12.71
3ko0Q-4e2pA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		4 PHE A 324
GLY A 335
PHE A 334
PHE A 310
 None
 0.95A 3ko0O-4fe9A:
undetectable
3ko0Q-4fe9A:
undetectable		 3ko0O-4fe9A:
11.54
3ko0Q-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		4 GLY A 271
PHE A 159
CYH A 231
PHE A 230
 None
 0.98A 3ko0O-4gz2A:
undetectable
3ko0Q-4gz2A:
undetectable		 3ko0O-4gz2A:
16.73
3ko0Q-4gz2A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 PHE A  75
GLY A  76
PHE A 220
PHE A 249
 None
 0.91A 3ko0O-4jb7A:
undetectable
3ko0Q-4jb7A:
undetectable		 3ko0O-4jb7A:
17.49
3ko0Q-4jb7A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		4 GLY A  22
PHE A  23
ILE A   7
PHE A  79
 None
 0.81A 3ko0O-4jbdA:
undetectable
3ko0Q-4jbdA:
undetectable		 3ko0O-4jbdA:
15.09
3ko0Q-4jbdA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 GLY A 292
PHE A 294
ILE A 328
PHE A 361
PHE A 307
 None
 1.34A 3ko0O-4kc8A:
undetectable
3ko0Q-4kc8A:
undetectable		 3ko0O-4kc8A:
13.27
3ko0Q-4kc8A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 GLY A  81
PHE A  82
ILE A 126
CYH A 153
 None
 0.86A 3ko0O-4kpnA:
undetectable
3ko0Q-4kpnA:
undetectable		 3ko0O-4kpnA:
13.57
3ko0Q-4kpnA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8r HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF16023
(DUF4784) 		4 GLY A 331
PHE A 330
PHE A 364
PHE A 382
 None
 0.81A 3ko0O-4m8rA:
undetectable
3ko0Q-4m8rA:
undetectable		 3ko0O-4m8rA:
16.58
3ko0Q-4m8rA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 PHE A 597
GLY A 585
ILE A 621
CYH A 623
 None
 0.89A 3ko0O-4m9pA:
undetectable
3ko0Q-4m9pA:
undetectable		 3ko0O-4m9pA:
16.85
3ko0Q-4m9pA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 PHE A 234
GLY A 210
PHE A 209
PHE A 217
 None
 0.86A 3ko0O-4madA:
undetectable
3ko0Q-4madA:
undetectable		 3ko0O-4madA:
9.00
3ko0Q-4madA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 GLY A 152
PHE A 151
ILE A 107
PHE A 195
 None
 0.96A 3ko0O-4mlgA:
undetectable
3ko0Q-4mlgA:
undetectable		 3ko0O-4mlgA:
15.26
3ko0Q-4mlgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwv CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 PHE A 266
PHE A 268
ILE A 300
PHE A 377
 None
 0.89A 3ko0O-4nwvA:
undetectable
3ko0Q-4nwvA:
undetectable		 3ko0O-4nwvA:
12.74
3ko0Q-4nwvA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 PHE A 266
PHE A 268
ILE A 300
PHE A 377
 None
 0.90A 3ko0O-4nwwA:
undetectable
3ko0Q-4nwwA:
undetectable		 3ko0O-4nwwA:
14.53
3ko0Q-4nwwA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		4 GLY A  23
PHE A  24
ILE A   8
PHE A  80
 None
 0.88A 3ko0O-4q60A:
undetectable
3ko0Q-4q60A:
undetectable		 3ko0O-4q60A:
13.55
3ko0Q-4q60A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 PHE A 187
GLY A 186
PHE A 182
PHE A 350
PHE A 171
 None
 1.46A 3ko0O-4rapA:
undetectable
3ko0Q-4rapA:
undetectable		 3ko0O-4rapA:
14.36
3ko0Q-4rapA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		4 GLY A 257
ILE A 281
MET A 283
CYH A 284
 None
 0.94A 3ko0O-4rk1A:
undetectable
3ko0Q-4rk1A:
undetectable		 3ko0O-4rk1A:
16.43
3ko0Q-4rk1A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		5 GLY A 245
PHE A 244
ILE A 335
MET A 331
PHE A 276
 None
 1.46A 3ko0O-4rp8A:
undetectable
3ko0Q-4rp8A:
0.0		 3ko0O-4rp8A:
11.02
3ko0Q-4rp8A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 4 GLY F 203
PHE F 204
ILE F 171
PHE F 267
 None
 0.88A 3ko0O-4wmoF:
undetectable
3ko0Q-4wmoF:
undetectable		 3ko0O-4wmoF:
16.12
3ko0Q-4wmoF:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens) 		no annotation 4 GLY A 174
PHE A 175
ILE A 142
PHE A 238
 None
 0.78A 3ko0O-4wmyA:
undetectable
3ko0Q-4wmyA:
undetectable		 3ko0O-4wmyA:
16.22
3ko0Q-4wmyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 GLY A 190
ILE A 217
MET A 250
CYH A 249
 None
 0.92A 3ko0O-4z8xA:
undetectable
3ko0Q-4z8xA:
undetectable		 3ko0O-4z8xA:
12.24
3ko0Q-4z8xA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 GLY A  24
PHE A  25
ILE A 159
PHE A 206
 None
None
GSH  A 401 (-3.6A)
None
 0.93A 3ko0O-4z9nA:
undetectable
3ko0Q-4z9nA:
undetectable		 3ko0O-4z9nA:
16.04
3ko0Q-4z9nA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1k ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 PHE A 283
GLY A 298
PHE A 272
PHE A 344
 None
 0.91A 3ko0O-5a1kA:
0.9
3ko0Q-5a1kA:
0.9		 3ko0O-5a1kA:
17.30
3ko0Q-5a1kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1m ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 PHE A 283
GLY A 298
PHE A 272
PHE A 344
 None
 0.98A 3ko0O-5a1mA:
undetectable
3ko0Q-5a1mA:
undetectable		 3ko0O-5a1mA:
22.41
3ko0Q-5a1mA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 4 GLY A 109
PHE A 135
ILE A 100
PHE A 175
 None
 0.91A 3ko0O-5b5xA:
2.8
3ko0Q-5b5xA:
undetectable		 3ko0O-5b5xA:
15.46
3ko0Q-5b5xA:
15.46