SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_P_TFPP202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 SER A 130
ASP A 145
LEU A 142
PHE A  86
ILE A  18
 None
 1.18A 3ko0M-1ag9A:
undetectable
3ko0N-1ag9A:
undetectable
3ko0O-1ag9A:
undetectable
3ko0P-1ag9A:
undetectable		 3ko0M-1ag9A:
22.70
3ko0N-1ag9A:
22.70
3ko0O-1ag9A:
22.70
3ko0P-1ag9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgn ICEBERG (PROTEASE
INHIBITOR)

(Homo sapiens) 		PF00619
(CARD) 		5 LEU A   5
ASP A   3
LEU A  89
ILE A  73
CYH A  69
 None
 1.19A 3ko0M-1dgnA:
undetectable
3ko0N-1dgnA:
undetectable
3ko0O-1dgnA:
undetectable
3ko0P-1dgnA:
undetectable		 3ko0M-1dgnA:
25.71
3ko0N-1dgnA:
25.71
3ko0O-1dgnA:
25.71
3ko0P-1dgnA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 GLU A 101
LEU A 105
ASP A 103
LEU A  71
CYH A 112
 None
 1.11A 3ko0M-1dj2A:
undetectable
3ko0N-1dj2A:
undetectable
3ko0O-1dj2A:
undetectable
3ko0P-1dj2A:
undetectable		 3ko0M-1dj2A:
11.74
3ko0N-1dj2A:
11.74
3ko0O-1dj2A:
11.74
3ko0P-1dj2A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 GLU A 101
LEU A 105
LEU A  71
ILE A  78
CYH A 112
 None
 1.11A 3ko0M-1dj2A:
undetectable
3ko0N-1dj2A:
undetectable
3ko0O-1dj2A:
undetectable
3ko0P-1dj2A:
undetectable		 3ko0M-1dj2A:
11.74
3ko0N-1dj2A:
11.74
3ko0O-1dj2A:
11.74
3ko0P-1dj2A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		5 GLU A 100
LEU A 104
LEU A  70
ILE A  77
CYH A 111
 None
 1.15A 3ko0M-1dj3A:
undetectable
3ko0N-1dj3A:
undetectable
3ko0O-1dj3A:
undetectable
3ko0P-1dj3A:
undetectable		 3ko0M-1dj3A:
12.90
3ko0N-1dj3A:
12.90
3ko0O-1dj3A:
12.90
3ko0P-1dj3A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 ASP A  92
SER A  99
GLU A 137
LEU A 136
ASP A 180
 None
 1.21A 3ko0M-1dysA:
0.0
3ko0N-1dysA:
undetectable
3ko0O-1dysA:
undetectable
3ko0P-1dysA:
undetectable		 3ko0M-1dysA:
10.63
3ko0N-1dysA:
10.63
3ko0O-1dysA:
10.63
3ko0P-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 ASP A 252
GLU A 343
LEU A 339
SER A 340
PHE A 344
 None
 1.04A 3ko0M-1ij5A:
7.1
3ko0N-1ij5A:
7.3
3ko0O-1ij5A:
7.1
3ko0P-1ij5A:
7.0		 3ko0M-1ij5A:
17.12
3ko0N-1ij5A:
17.12
3ko0O-1ij5A:
17.12
3ko0P-1ij5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		5 ASP A  73
LEU A  45
LEU A 121
PHE A  82
ILE A  49
 None
 1.17A 3ko0M-1jn1A:
undetectable
3ko0N-1jn1A:
undetectable
3ko0O-1jn1A:
undetectable
3ko0P-1jn1A:
undetectable		 3ko0M-1jn1A:
20.67
3ko0N-1jn1A:
20.67
3ko0O-1jn1A:
20.67
3ko0P-1jn1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 GLU A 150
LEU A 151
ASP A 149
LEU A 110
PHE A 109
 None
 1.16A 3ko0M-1ni3A:
undetectable
3ko0N-1ni3A:
undetectable
3ko0O-1ni3A:
undetectable
3ko0P-1ni3A:
undetectable		 3ko0M-1ni3A:
12.47
3ko0N-1ni3A:
12.47
3ko0O-1ni3A:
12.47
3ko0P-1ni3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 482
ASP A 439
LEU A 436
SER A 486
ILE A 423
 None
 1.11A 3ko0M-1pz3A:
undetectable
3ko0N-1pz3A:
undetectable
3ko0O-1pz3A:
undetectable
3ko0P-1pz3A:
undetectable		 3ko0M-1pz3A:
12.17
3ko0N-1pz3A:
12.17
3ko0O-1pz3A:
12.17
3ko0P-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A 325
LEU A 296
SER A 297
PHE A 301
ILE A 304
 None
 1.09A 3ko0M-1pztA:
undetectable
3ko0N-1pztA:
undetectable
3ko0O-1pztA:
undetectable
3ko0P-1pztA:
undetectable		 3ko0M-1pztA:
17.80
3ko0N-1pztA:
17.80
3ko0O-1pztA:
17.80
3ko0P-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 ASP A  24
LEU A  64
LEU A  32
PHE A  29
ILE A 108
 None
 1.20A 3ko0M-1q3bA:
0.3
3ko0N-1q3bA:
undetectable
3ko0O-1q3bA:
undetectable
3ko0P-1q3bA:
undetectable		 3ko0M-1q3bA:
17.05
3ko0N-1q3bA:
17.05
3ko0O-1q3bA:
17.05
3ko0P-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ASP A 277
SER A 280
LEU A 110
ASP A 111
LEU A 243
 None
 1.03A 3ko0M-1vp4A:
0.0
3ko0N-1vp4A:
undetectable
3ko0O-1vp4A:
undetectable
3ko0P-1vp4A:
undetectable		 3ko0M-1vp4A:
13.44
3ko0N-1vp4A:
13.44
3ko0O-1vp4A:
13.44
3ko0P-1vp4A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		5 LEU A  31
ASP A  32
LEU A  68
SER A  69
ILE A  64
 POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
None
None
None
 1.07A 3ko0M-1wozA:
0.8
3ko0N-1wozA:
undetectable
3ko0O-1wozA:
undetectable
3ko0P-1wozA:
undetectable		 3ko0M-1wozA:
20.57
3ko0N-1wozA:
20.57
3ko0O-1wozA:
20.57
3ko0P-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 303
LEU A 285
SER A 266
ILE A 301
PHE A 224
 None
 1.14A 3ko0M-1x9eA:
0.0
3ko0N-1x9eA:
undetectable
3ko0O-1x9eA:
undetectable
3ko0P-1x9eA:
undetectable		 3ko0M-1x9eA:
14.44
3ko0N-1x9eA:
14.44
3ko0O-1x9eA:
14.44
3ko0P-1x9eA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLU A 181
LEU A 177
SER A 178
PHE A 182
ILE A 185
 None
 1.14A 3ko0M-1ykwA:
undetectable
3ko0N-1ykwA:
undetectable
3ko0O-1ykwA:
undetectable
3ko0P-1ykwA:
undetectable		 3ko0M-1ykwA:
12.47
3ko0N-1ykwA:
12.47
3ko0O-1ykwA:
12.47
3ko0P-1ykwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ASP A  13
LEU A  25
SER A  24
ILE A  36
CYH A  10
 None
 1.17A 3ko0M-1zzmA:
0.0
3ko0N-1zzmA:
undetectable
3ko0O-1zzmA:
undetectable
3ko0P-1zzmA:
undetectable		 3ko0M-1zzmA:
14.89
3ko0N-1zzmA:
14.89
3ko0O-1zzmA:
14.89
3ko0P-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 SER A 202
GLU A 148
LEU A 136
ASP A 162
ILE A 139
 None
 1.18A 3ko0M-2a9fA:
0.2
3ko0N-2a9fA:
undetectable
3ko0O-2a9fA:
undetectable
3ko0P-2a9fA:
undetectable		 3ko0M-2a9fA:
15.98
3ko0N-2a9fA:
15.98
3ko0O-2a9fA:
15.98
3ko0P-2a9fA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 SER A 186
LEU A 151
SER A 154
PHE A 156
ILE A 331
 None
 1.20A 3ko0M-2c4kA:
undetectable
3ko0N-2c4kA:
undetectable
3ko0O-2c4kA:
undetectable
3ko0P-2c4kA:
undetectable		 3ko0M-2c4kA:
12.83
3ko0N-2c4kA:
12.83
3ko0O-2c4kA:
12.83
3ko0P-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 SER A 168
LEU A  59
LEU A 175
ILE A  55
PHE A   7
 None
 1.14A 3ko0M-2e0iA:
0.0
3ko0N-2e0iA:
undetectable
3ko0O-2e0iA:
undetectable
3ko0P-2e0iA:
undetectable		 3ko0M-2e0iA:
12.59
3ko0N-2e0iA:
12.59
3ko0O-2e0iA:
12.59
3ko0P-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A 288
LEU A 130
SER A 128
PHE A 129
ILE A 317
 None
 0.88A 3ko0M-2fqxA:
undetectable
3ko0N-2fqxA:
undetectable
3ko0O-2fqxA:
undetectable
3ko0P-2fqxA:
undetectable		 3ko0M-2fqxA:
13.92
3ko0N-2fqxA:
13.92
3ko0O-2fqxA:
13.92
3ko0P-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 GLU A 160
LEU A 134
LEU A 156
SER A 157
ILE A 164
 None
 1.19A 3ko0M-2ghiA:
undetectable
3ko0N-2ghiA:
undetectable
3ko0O-2ghiA:
undetectable
3ko0P-2ghiA:
undetectable		 3ko0M-2ghiA:
17.14
3ko0N-2ghiA:
17.14
3ko0O-2ghiA:
17.14
3ko0P-2ghiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 845
LEU A 910
PHE A 909
ILE A 888
CYH A 892
 None
 0.98A 3ko0M-2ogvA:
undetectable
3ko0N-2ogvA:
undetectable
3ko0O-2ogvA:
undetectable
3ko0P-2ogvA:
undetectable		 3ko0M-2ogvA:
15.41
3ko0N-2ogvA:
15.41
3ko0O-2ogvA:
15.41
3ko0P-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		5 PHE B 228
ASP B 178
SER B 150
LEU B 118
LEU B 142
 None
 1.23A 3ko0M-2p5tB:
undetectable
3ko0N-2p5tB:
undetectable
3ko0O-2p5tB:
undetectable
3ko0P-2p5tB:
undetectable		 3ko0M-2p5tB:
17.25
3ko0N-2p5tB:
17.25
3ko0O-2p5tB:
17.25
3ko0P-2p5tB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmu RESPONSE REGULATOR
PHOP

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		5 GLU A 178
LEU A 221
LEU A 174
SER A 175
PHE A 179
 None
 1.18A 3ko0M-2pmuA:
undetectable
3ko0N-2pmuA:
undetectable
3ko0O-2pmuA:
undetectable
3ko0P-2pmuA:
undetectable		 3ko0M-2pmuA:
19.82
3ko0N-2pmuA:
19.82
3ko0O-2pmuA:
19.82
3ko0P-2pmuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE

(uncultured
Thermotogales
bacterium) 		PF01966
(HD) 		5 PHE A  96
ASP A  54
LEU A  63
LEU A  13
ILE A  16
 None
 1.23A 3ko0M-2pq7A:
undetectable
3ko0N-2pq7A:
undetectable
3ko0O-2pq7A:
undetectable
3ko0P-2pq7A:
undetectable		 3ko0M-2pq7A:
18.18
3ko0N-2pq7A:
18.18
3ko0O-2pq7A:
18.18
3ko0P-2pq7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		5 ASP A 428
LEU A 459
LEU A 438
SER A 435
PHE A 437
 None
 1.24A 3ko0M-2q01A:
undetectable
3ko0N-2q01A:
undetectable
3ko0O-2q01A:
undetectable
3ko0P-2q01A:
undetectable		 3ko0M-2q01A:
12.74
3ko0N-2q01A:
12.74
3ko0O-2q01A:
12.74
3ko0P-2q01A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 ASP A 257
LEU A 117
LEU A  82
SER A  84
PHE A  86
 None
 1.12A 3ko0M-2q83A:
undetectable
3ko0N-2q83A:
undetectable
3ko0O-2q83A:
undetectable
3ko0P-2q83A:
undetectable		 3ko0M-2q83A:
15.38
3ko0N-2q83A:
15.38
3ko0O-2q83A:
15.38
3ko0P-2q83A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkl SPAC19A8.12 PROTEIN

(Schizosaccharomyces
pombe) 		PF05026
(DCP2) 		5 ASP B  87
LEU B  75
LEU B  68
SER B  65
ILE B  20
 None
 1.23A 3ko0M-2qklB:
undetectable
3ko0N-2qklB:
undetectable
3ko0O-2qklB:
undetectable
3ko0P-2qklB:
undetectable		 3ko0M-2qklB:
22.12
3ko0N-2qklB:
22.12
3ko0O-2qklB:
22.12
3ko0P-2qklB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 LEU A 453
LEU A 499
SER A 501
PHE A 503
ILE A 506
 None
 1.24A 3ko0M-2qnaA:
undetectable
3ko0N-2qnaA:
undetectable
3ko0O-2qnaA:
undetectable
3ko0P-2qnaA:
undetectable		 3ko0M-2qnaA:
9.71
3ko0N-2qnaA:
9.71
3ko0O-2qnaA:
9.71
3ko0P-2qnaA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.09A 3ko0M-2v26A:
undetectable
3ko0N-2v26A:
undetectable
3ko0O-2v26A:
undetectable
3ko0P-2v26A:
undetectable		 3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
3ko0O-2v26A:
9.24
3ko0P-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 PHE B  85
LEU B 106
LEU B  68
SER B  70
PHE B  71
 None
HEM  B 401 ( 4.5A)
None
HEM  B 401 ( 3.8A)
None
 1.22A 3ko0M-3a0gB:
undetectable
3ko0N-3a0gB:
undetectable
3ko0O-3a0gB:
undetectable
3ko0P-3a0gB:
undetectable		 3ko0M-3a0gB:
21.92
3ko0N-3a0gB:
21.92
3ko0O-3a0gB:
21.92
3ko0P-3a0gB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 SER A 479
LEU A 577
LEU A 448
PHE A 444
ILE A 572
 None
 1.23A 3ko0M-3ctzA:
undetectable
3ko0N-3ctzA:
undetectable
3ko0O-3ctzA:
undetectable
3ko0P-3ctzA:
undetectable		 3ko0M-3ctzA:
9.50
3ko0N-3ctzA:
9.50
3ko0O-3ctzA:
9.50
3ko0P-3ctzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 ASP A 164
SER A 171
PHE A 410
ILE A 395
PHE A 298
 None
 1.18A 3ko0M-3eafA:
undetectable
3ko0N-3eafA:
undetectable
3ko0O-3eafA:
undetectable
3ko0P-3eafA:
undetectable		 3ko0M-3eafA:
12.92
3ko0N-3eafA:
12.92
3ko0O-3eafA:
12.92
3ko0P-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 154
LEU A 146
ILE A 122
CYH A 133
PHE A 132
 None
 1.15A 3ko0M-3fkdA:
undetectable
3ko0N-3fkdA:
undetectable
3ko0O-3fkdA:
undetectable
3ko0P-3fkdA:
undetectable		 3ko0M-3fkdA:
12.82
3ko0N-3fkdA:
12.82
3ko0O-3fkdA:
12.82
3ko0P-3fkdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8w LACTOCOCCAL PROPHAGE
PS3 PROTEIN 05

(Staphylococcus
epidermidis) 		PF13420
(Acetyltransf_4) 		5 LEU A  69
LEU A 115
ILE A 103
CYH A  67
PHE A  87
 None
 1.18A 3ko0M-3g8wA:
undetectable
3ko0N-3g8wA:
undetectable
3ko0O-3g8wA:
undetectable
3ko0P-3g8wA:
undetectable		 3ko0M-3g8wA:
25.00
3ko0N-3g8wA:
25.00
3ko0O-3g8wA:
25.00
3ko0P-3g8wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 312
LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 1.10A 3ko0M-3h11A:
undetectable
3ko0N-3h11A:
undetectable
3ko0O-3h11A:
undetectable
3ko0P-3h11A:
undetectable		 3ko0M-3h11A:
15.79
3ko0N-3h11A:
15.79
3ko0O-3h11A:
15.79
3ko0P-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 LEU A 380
ASP A 379
LEU A 133
SER A 130
ILE A 403
 None
 1.08A 3ko0M-3hq2A:
undetectable
3ko0N-3hq2A:
undetectable
3ko0O-3hq2A:
undetectable
3ko0P-3hq2A:
undetectable		 3ko0M-3hq2A:
12.15
3ko0N-3hq2A:
12.15
3ko0O-3hq2A:
12.15
3ko0P-3hq2A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 PHE A 240
ASP A 172
LEU A 181
SER A 178
ILE A  68
 None
 1.16A 3ko0M-3hwpA:
undetectable
3ko0N-3hwpA:
undetectable
3ko0O-3hwpA:
undetectable
3ko0P-3hwpA:
undetectable		 3ko0M-3hwpA:
15.77
3ko0N-3hwpA:
15.77
3ko0O-3hwpA:
15.77
3ko0P-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 PHE A 381
LEU A 437
ASP A 436
LEU A 416
ILE A 408
 None
None
NDG  A4701 ( 3.1A)
None
None
 1.12A 3ko0M-3i2tA:
undetectable
3ko0N-3i2tA:
undetectable
3ko0O-3i2tA:
undetectable
3ko0P-3i2tA:
undetectable		 3ko0M-3i2tA:
11.34
3ko0N-3i2tA:
11.34
3ko0O-3i2tA:
11.34
3ko0P-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2w SYNDAPIN

(Drosophila
melanogaster) 		PF00611
(FCH) 		5 LEU A 103
ASP A 106
LEU A 253
SER A 251
ILE A  99
 None
 1.23A 3ko0M-3i2wA:
undetectable
3ko0N-3i2wA:
undetectable
3ko0O-3i2wA:
undetectable
3ko0P-3i2wA:
undetectable		 3ko0M-3i2wA:
15.99
3ko0N-3i2wA:
15.99
3ko0O-3i2wA:
15.99
3ko0P-3i2wA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		5 GLU A 578
LEU A 585
ASP A 581
LEU A 626
PHE A 548
 None
 1.19A 3ko0M-3k7dA:
undetectable
3ko0N-3k7dA:
undetectable
3ko0O-3k7dA:
undetectable
3ko0P-3k7dA:
undetectable		 3ko0M-3k7dA:
12.83
3ko0N-3k7dA:
12.83
3ko0O-3k7dA:
12.83
3ko0P-3k7dA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 5 SER A 377
LEU A 230
SER A 331
ILE A 254
PHE A 251
 None
 1.15A 3ko0M-3l15A:
undetectable
3ko0N-3l15A:
undetectable
3ko0O-3l15A:
undetectable
3ko0P-3l15A:
undetectable		 3ko0M-3l15A:
20.36
3ko0N-3l15A:
20.36
3ko0O-3l15A:
20.36
3ko0P-3l15A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 SER A 203
LEU A 272
LEU A 166
SER A 169
PHE A 170
 None
 0.93A 3ko0M-3mjoA:
1.0
3ko0N-3mjoA:
undetectable
3ko0O-3mjoA:
0.8
3ko0P-3mjoA:
1.0		 3ko0M-3mjoA:
17.12
3ko0N-3mjoA:
17.12
3ko0O-3mjoA:
17.12
3ko0P-3mjoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 ASP A 205
LEU A 212
SER A 213
PHE A 211
ILE A 208
 None
None
None
None
DTD  A 248 ( 4.1A)
 1.22A 3ko0M-3oqvA:
undetectable
3ko0N-3oqvA:
undetectable
3ko0O-3oqvA:
undetectable
3ko0P-3oqvA:
undetectable		 3ko0M-3oqvA:
15.73
3ko0N-3oqvA:
15.73
3ko0O-3oqvA:
15.73
3ko0P-3oqvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		5 PHE A 253
LEU A 223
ASP A 222
LEU A 203
ILE A 169
 None
 1.12A 3ko0M-3skvA:
undetectable
3ko0N-3skvA:
undetectable
3ko0O-3skvA:
undetectable
3ko0P-3skvA:
undetectable		 3ko0M-3skvA:
14.71
3ko0N-3skvA:
14.71
3ko0O-3skvA:
14.71
3ko0P-3skvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 PHE A 777
LEU A 435
ASP A 436
LEU A 431
ILE A 262
 EDO  A 795 ( 3.6A)
None
None
None
None
 0.84A 3ko0M-3tbkA:
undetectable
3ko0N-3tbkA:
undetectable
3ko0O-3tbkA:
undetectable
3ko0P-3tbkA:
undetectable		 3ko0M-3tbkA:
10.99
3ko0N-3tbkA:
10.99
3ko0O-3tbkA:
10.99
3ko0P-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 ASP A 132
LEU A 260
LEU A 324
SER A 321
ILE A 293
 None
 1.21A 3ko0M-3uduA:
undetectable
3ko0N-3uduA:
undetectable
3ko0O-3uduA:
undetectable
3ko0P-3uduA:
undetectable		 3ko0M-3uduA:
16.22
3ko0N-3uduA:
16.22
3ko0O-3uduA:
16.22
3ko0P-3uduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.17A 3ko0M-4anjA:
undetectable
3ko0N-4anjA:
undetectable
3ko0O-4anjA:
undetectable
3ko0P-4anjA:
undetectable		 3ko0M-4anjA:
6.93
3ko0N-4anjA:
6.93
3ko0O-4anjA:
6.93
3ko0P-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ASP A  58
LEU A  51
LEU A  29
SER A  30
ILE A  25
 None
 1.24A 3ko0M-4awnA:
undetectable
3ko0N-4awnA:
undetectable
3ko0O-4awnA:
undetectable
3ko0P-4awnA:
undetectable		 3ko0M-4awnA:
16.33
3ko0N-4awnA:
16.33
3ko0O-4awnA:
16.33
3ko0P-4awnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 PHE A 776
LEU A 434
ASP A 435
LEU A 430
ILE A 261
 None
 0.88A 3ko0M-4ay2A:
undetectable
3ko0N-4ay2A:
undetectable
3ko0O-4ay2A:
undetectable
3ko0P-4ay2A:
undetectable		 3ko0M-4ay2A:
9.75
3ko0N-4ay2A:
9.75
3ko0O-4ay2A:
9.75
3ko0P-4ay2A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 ASP A 351
ASP A 318
LEU A 332
PHE A 327
ILE A 325
 None
 1.19A 3ko0M-4bhdA:
undetectable
3ko0N-4bhdA:
undetectable
3ko0O-4bhdA:
undetectable
3ko0P-4bhdA:
undetectable		 3ko0M-4bhdA:
12.38
3ko0N-4bhdA:
12.38
3ko0O-4bhdA:
12.38
3ko0P-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 GLU A 214
LEU A 228
SER A 231
ILE A 288
PHE A 252
 None
 1.16A 3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable
3ko0O-4fidA:
undetectable
3ko0P-4fidA:
undetectable		 3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
3ko0O-4fidA:
15.16
3ko0P-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 PHE A 208
GLU A 214
LEU A 228
SER A 231
PHE A 252
 None
 1.13A 3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable
3ko0O-4fidA:
undetectable
3ko0P-4fidA:
undetectable		 3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
3ko0O-4fidA:
15.16
3ko0P-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A 117
ASP A  70
LEU A  84
LEU A 164
SER A 120
 None
 1.22A 3ko0M-4h5iA:
undetectable
3ko0N-4h5iA:
undetectable
3ko0O-4h5iA:
undetectable
3ko0P-4h5iA:
undetectable		 3ko0M-4h5iA:
15.69
3ko0N-4h5iA:
15.69
3ko0O-4h5iA:
15.69
3ko0P-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.18A 3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1
3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.9		 3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 GLU A 350
LEU A 347
ASP A 346
LEU A 364
ILE A 368
 None
 1.01A 3ko0M-4iggA:
undetectable
3ko0N-4iggA:
undetectable
3ko0O-4iggA:
undetectable
3ko0P-4iggA:
undetectable		 3ko0M-4iggA:
9.16
3ko0N-4iggA:
9.16
3ko0O-4iggA:
9.16
3ko0P-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A 240
ASP A 241
LEU A  45
PHE A  66
ILE A  11
 None
 1.12A 3ko0M-4iwmA:
undetectable
3ko0N-4iwmA:
undetectable
3ko0O-4iwmA:
undetectable
3ko0P-4iwmA:
undetectable		 3ko0M-4iwmA:
17.05
3ko0N-4iwmA:
17.05
3ko0O-4iwmA:
17.05
3ko0P-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		5 SER A 353
LEU A 108
ASP A 109
LEU A 235
ILE A  98
 None
 0.84A 3ko0M-4j1lA:
undetectable
3ko0N-4j1lA:
undetectable
3ko0O-4j1lA:
undetectable
3ko0P-4j1lA:
undetectable		 3ko0M-4j1lA:
14.29
3ko0N-4j1lA:
14.29
3ko0O-4j1lA:
14.29
3ko0P-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 LEU A 152
SER A 150
PHE A 151
ILE A  30
PHE A  38
 None
 1.17A 3ko0M-4jhiA:
undetectable
3ko0N-4jhiA:
undetectable
3ko0O-4jhiA:
undetectable
3ko0P-4jhiA:
undetectable		 3ko0M-4jhiA:
18.29
3ko0N-4jhiA:
18.29
3ko0O-4jhiA:
18.29
3ko0P-4jhiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 LEU A1480
ASP A1476
LEU A1524
SER A1523
ILE A1481
 None
 1.22A 3ko0M-4lnzA:
1.6
3ko0N-4lnzA:
1.6
3ko0O-4lnzA:
1.7
3ko0P-4lnzA:
1.6		 3ko0M-4lnzA:
14.90
3ko0N-4lnzA:
14.90
3ko0O-4lnzA:
14.90
3ko0P-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PHE A 332
LEU A 266
LEU A 349
SER A 345
ILE A 352
 None
PGE  A 509 (-4.9A)
None
None
None
 1.18A 3ko0M-4mrqA:
undetectable
3ko0N-4mrqA:
undetectable
3ko0O-4mrqA:
undetectable
3ko0P-4mrqA:
undetectable		 3ko0M-4mrqA:
12.13
3ko0N-4mrqA:
12.13
3ko0O-4mrqA:
12.13
3ko0P-4mrqA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 PHE A 776
LEU A 434
ASP A 435
LEU A 430
ILE A 261
 None
 0.97A 3ko0M-4on9A:
undetectable
3ko0N-4on9A:
undetectable
3ko0O-4on9A:
undetectable
3ko0P-4on9A:
undetectable		 3ko0M-4on9A:
10.86
3ko0N-4on9A:
10.86
3ko0O-4on9A:
10.86
3ko0P-4on9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 PHE A  65
GLU A 132
LEU A  70
SER A  67
ILE A 292
 UNX  A 408 ( 4.8A)
UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
 1.16A 3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable
3ko0O-4pwyA:
undetectable
3ko0P-4pwyA:
undetectable		 3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
3ko0O-4pwyA:
18.85
3ko0P-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 LEU A  74
LEU A  51
SER A  54
ILE A  78
PHE A1722
 None
 1.17A 3ko0M-4r04A:
undetectable
3ko0N-4r04A:
undetectable
3ko0O-4r04A:
undetectable
3ko0P-4r04A:
undetectable		 3ko0M-4r04A:
4.44
3ko0N-4r04A:
4.44
3ko0O-4r04A:
4.44
3ko0P-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 377
ASP A 405
LEU A 390
ILE A 382
CYH A 409
 None
 0.95A 3ko0M-4r5dA:
undetectable
3ko0N-4r5dA:
undetectable
3ko0O-4r5dA:
undetectable
3ko0P-4r5dA:
undetectable		 3ko0M-4r5dA:
10.93
3ko0N-4r5dA:
10.93
3ko0O-4r5dA:
10.93
3ko0P-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		5 GLU A 169
LEU A 173
LEU A  37
ILE A  42
CYH A 161
 None
 1.24A 3ko0M-4r94A:
undetectable
3ko0N-4r94A:
undetectable
3ko0O-4r94A:
undetectable
3ko0P-4r94A:
undetectable		 3ko0M-4r94A:
16.86
3ko0N-4r94A:
16.86
3ko0O-4r94A:
16.86
3ko0P-4r94A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 PHE A 162
LEU A 114
ASP A 113
LEU A  95
ILE A 120
 None
 1.07A 3ko0M-4s1aA:
undetectable
3ko0N-4s1aA:
undetectable
3ko0O-4s1aA:
undetectable
3ko0P-4s1aA:
undetectable		 3ko0M-4s1aA:
18.98
3ko0N-4s1aA:
18.98
3ko0O-4s1aA:
18.98
3ko0P-4s1aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL

(Plasmodium
berghei) 		no annotation 5 LEU A  57
ASP A  60
PHE A 115
ILE A 138
CYH A 142
 None
 1.24A 3ko0M-4u5aA:
1.9
3ko0N-4u5aA:
1.9
3ko0O-4u5aA:
1.9
3ko0P-4u5aA:
1.9		 3ko0M-4u5aA:
20.30
3ko0N-4u5aA:
20.30
3ko0O-4u5aA:
20.30
3ko0P-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 GLU C 592
LEU C 593
LEU C 359
ILE C 590
CYH C 396
 None
 1.18A 3ko0M-4xgcC:
2.7
3ko0N-4xgcC:
2.7
3ko0O-4xgcC:
2.6
3ko0P-4xgcC:
2.7		 3ko0M-4xgcC:
8.97
3ko0N-4xgcC:
8.97
3ko0O-4xgcC:
8.97
3ko0P-4xgcC:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2830
ASP A2854
LEU A2842
SER A2844
PHE A2845
 None
 1.24A 3ko0M-4z37A:
undetectable
3ko0N-4z37A:
undetectable
3ko0O-4z37A:
undetectable
3ko0P-4z37A:
undetectable		 3ko0M-4z37A:
9.61
3ko0N-4z37A:
9.61
3ko0O-4z37A:
9.61
3ko0P-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 627
LEU A 588
ASP A 587
LEU A 577
ILE A 573
 None
 1.05A 3ko0M-4z61A:
undetectable
3ko0N-4z61A:
undetectable
3ko0O-4z61A:
undetectable
3ko0P-4z61A:
undetectable		 3ko0M-4z61A:
10.84
3ko0N-4z61A:
10.84
3ko0O-4z61A:
10.84
3ko0P-4z61A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 159
LEU A 107
ASP A 130
LEU A  92
ILE A 112
 None
None
NAG  A 701 (-3.7A)
None
None
 1.23A 3ko0M-4z64A:
undetectable
3ko0N-4z64A:
undetectable
3ko0O-4z64A:
undetectable
3ko0P-4z64A:
undetectable		 3ko0M-4z64A:
11.79
3ko0N-4z64A:
11.79
3ko0O-4z64A:
11.79
3ko0P-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 PHE A 617
LEU A 578
ASP A 577
LEU A 567
ILE A 563
 None
 1.09A 3ko0M-4z64A:
undetectable
3ko0N-4z64A:
undetectable
3ko0O-4z64A:
undetectable
3ko0P-4z64A:
undetectable		 3ko0M-4z64A:
11.79
3ko0N-4z64A:
11.79
3ko0O-4z64A:
11.79
3ko0P-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 SER A  40
LEU A  56
ASP A  57
LEU A 126
PHE A 122
 DMS  A1314 ( 3.7A)
None
None
None
None
 1.19A 3ko0M-5advA:
undetectable
3ko0N-5advA:
undetectable
3ko0O-5advA:
undetectable
3ko0P-5advA:
undetectable		 3ko0M-5advA:
15.55
3ko0N-5advA:
15.55
3ko0O-5advA:
15.55
3ko0P-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 GLU A 106
LEU A 109
LEU A  50
SER A  51
ILE A  46
 None
 1.00A 3ko0M-5azdA:
1.8
3ko0N-5azdA:
1.5
3ko0O-5azdA:
1.7
3ko0P-5azdA:
1.8		 3ko0M-5azdA:
15.53
3ko0N-5azdA:
15.53
3ko0O-5azdA:
15.53
3ko0P-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 ASP B  16
LEU A 387
LEU B 168
SER B  83
PHE B  82
 EDO  B 205 (-3.6A)
None
None
None
None
 1.12A 3ko0M-5b8iB:
6.2
3ko0N-5b8iB:
6.2
3ko0O-5b8iB:
6.2
3ko0P-5b8iB:
6.3		 3ko0M-5b8iB:
19.54
3ko0N-5b8iB:
19.54
3ko0O-5b8iB:
19.54
3ko0P-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 446
LEU A 338
SER A 339
PHE A 341
ILE A 426
 None
 1.17A 3ko0M-5c4tA:
undetectable
3ko0N-5c4tA:
1.1
3ko0O-5c4tA:
undetectable
3ko0P-5c4tA:
undetectable		 3ko0M-5c4tA:
17.08
3ko0N-5c4tA:
17.08
3ko0O-5c4tA:
17.08
3ko0P-5c4tA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 SER A1271
LEU A1090
LEU A1086
PHE A1083
CYH A1225
 None
 1.18A 3ko0M-5csaA:
undetectable
3ko0N-5csaA:
undetectable
3ko0O-5csaA:
undetectable
3ko0P-5csaA:
undetectable		 3ko0M-5csaA:
9.66
3ko0N-5csaA:
9.66
3ko0O-5csaA:
9.66
3ko0P-5csaA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 ASP A 417
GLU A  23
ASP A  64
LEU A  26
ILE A  61
 None
 1.20A 3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable		 3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 ASP A 417
SER A 403
GLU A  23
LEU A  26
ILE A  61
 None
 1.23A 3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable		 3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		5 GLU A 265
LEU A 261
ASP A 263
LEU A  24
ILE A 277
 None
 1.13A 3ko0M-5d86A:
undetectable
3ko0N-5d86A:
undetectable
3ko0O-5d86A:
undetectable
3ko0P-5d86A:
undetectable		 3ko0M-5d86A:
16.92
3ko0N-5d86A:
16.92
3ko0O-5d86A:
16.92
3ko0P-5d86A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 ASP E 237
LEU E 209
LEU E 285
PHE E 246
ILE E 213
 None
 1.16A 3ko0M-5esvE:
undetectable
3ko0N-5esvE:
undetectable
3ko0O-5esvE:
undetectable
3ko0P-5esvE:
undetectable		 3ko0M-5esvE:
20.39
3ko0N-5esvE:
20.39
3ko0O-5esvE:
20.39
3ko0P-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 ASP D 358
LEU D 382
LEU D 394
ILE D 401
CYH D 405
 None
 1.18A 3ko0M-5exrD:
undetectable
3ko0N-5exrD:
undetectable
3ko0O-5exrD:
undetectable
3ko0P-5exrD:
undetectable		 3ko0M-5exrD:
13.78
3ko0N-5exrD:
13.78
3ko0O-5exrD:
13.78
3ko0P-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 SER B 170
LEU B 276
ASP B 275
SER B 296
ILE B 305
 TCR  B 609 (-2.8A)
None
None
None
None
 1.23A 3ko0M-5fbhB:
undetectable
3ko0N-5fbhB:
undetectable
3ko0O-5fbhB:
undetectable
3ko0P-5fbhB:
undetectable		 3ko0M-5fbhB:
10.00
3ko0N-5fbhB:
10.00
3ko0O-5fbhB:
10.00
3ko0P-5fbhB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtq LUCIFERIN
REGENERATING ENZYME

(Photinus
pyralis) 		PF08450
(SGL) 		5 PHE A  60
LEU A 308
LEU A 143
ILE A  97
PHE A  71
 None
None
None
None
GOL  A 406 (-3.5A)
 1.23A 3ko0M-5gtqA:
undetectable
3ko0N-5gtqA:
undetectable
3ko0O-5gtqA:
undetectable
3ko0P-5gtqA:
undetectable		 3ko0M-5gtqA:
15.58
3ko0N-5gtqA:
15.58
3ko0O-5gtqA:
15.58
3ko0P-5gtqA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 SER A 164
LEU A  94
SER A  95
PHE A  69
ILE A  74
 None
 1.02A 3ko0M-5hyhA:
undetectable
3ko0N-5hyhA:
undetectable
3ko0O-5hyhA:
undetectable
3ko0P-5hyhA:
undetectable		 3ko0M-5hyhA:
14.19
3ko0N-5hyhA:
14.19
3ko0O-5hyhA:
14.19
3ko0P-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLU A 350
ASP A 351
LEU A 484
SER A 483
PHE A 487
 None
 1.15A 3ko0M-5iudA:
undetectable
3ko0N-5iudA:
undetectable
3ko0O-5iudA:
undetectable
3ko0P-5iudA:
undetectable		 3ko0M-5iudA:
7.87
3ko0N-5iudA:
7.87
3ko0O-5iudA:
7.87
3ko0P-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 ASP B 138
LEU B 164
LEU B 143
SER B 134
ILE B 183
 None
 1.10A 3ko0M-5k1cB:
undetectable
3ko0N-5k1cB:
undetectable
3ko0O-5k1cB:
undetectable
3ko0P-5k1cB:
undetectable		 3ko0M-5k1cB:
9.96
3ko0N-5k1cB:
9.96
3ko0O-5k1cB:
9.96
3ko0P-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 PHE A 420
ASP A 346
SER A 363
SER A 368
ILE A 413
 None
 1.20A 3ko0M-5kshA:
undetectable
3ko0N-5kshA:
undetectable
3ko0O-5kshA:
undetectable
3ko0P-5kshA:
undetectable		 3ko0M-5kshA:
10.70
3ko0N-5kshA:
10.70
3ko0O-5kshA:
10.70
3ko0P-5kshA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 SER B 112
LEU B 123
ASP B 122
LEU B 102
ILE B  99
 None
 1.15A 3ko0M-5l3sB:
undetectable
3ko0N-5l3sB:
undetectable
3ko0O-5l3sB:
undetectable
3ko0P-5l3sB:
undetectable		 3ko0M-5l3sB:
14.58
3ko0N-5l3sB:
14.58
3ko0O-5l3sB:
14.58
3ko0P-5l3sB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 5 ASP A 189
LEU A 199
LEU A  42
PHE A  41
ILE A 175
 None
 1.21A 3ko0M-5n72A:
undetectable
3ko0N-5n72A:
undetectable
3ko0O-5n72A:
undetectable
3ko0P-5n72A:
undetectable		 3ko0M-5n72A:
14.02
3ko0N-5n72A:
14.02
3ko0O-5n72A:
14.02
3ko0P-5n72A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		5 PHE 5 256
LEU 5 265
ASP 5 264
LEU 5 123
ILE 5 262
 None
None
U  A2387 ( 3.8A)
None
None
 1.24A 3ko0M-5ool5:
0.5
3ko0N-5ool5:
0.5
3ko0O-5ool5:
0.2
3ko0P-5ool5:
0.5		 3ko0M-5ool5:
12.80
3ko0N-5ool5:
12.80
3ko0O-5ool5:
12.80
3ko0P-5ool5:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 5 PHE A  75
LEU A 107
ASP A 108
LEU A 129
ILE A 104
 None
 1.09A 3ko0M-5ubvA:
undetectable
3ko0N-5ubvA:
undetectable
3ko0O-5ubvA:
undetectable
3ko0P-5ubvA:
undetectable		 3ko0M-5ubvA:
21.05
3ko0N-5ubvA:
21.05
3ko0O-5ubvA:
21.05
3ko0P-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxv SENSORY TRANSDUCTION
REGULATORY PROTEIN

(Bartonella
quintana) 		no annotation 5 ASP A  65
SER A  89
LEU A 127
PHE A  99
ILE A 102
 None
 1.03A 3ko0M-5uxvA:
undetectable
3ko0N-5uxvA:
undetectable
3ko0O-5uxvA:
undetectable
3ko0P-5uxvA:
undetectable		 3ko0M-5uxvA:
17.59
3ko0N-5uxvA:
17.59
3ko0O-5uxvA:
17.59
3ko0P-5uxvA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 ASP B  72
LEU B 111
ASP B 109
SER B 145
ILE B 150
 None
 1.10A 3ko0M-5y3rB:
undetectable
3ko0N-5y3rB:
undetectable
3ko0O-5y3rB:
undetectable
3ko0P-5y3rB:
undetectable		 3ko0M-5y3rB:
11.39
3ko0N-5y3rB:
11.39
3ko0O-5y3rB:
11.39
3ko0P-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 5 ASP A 209
LEU A 483
LEU A 468
SER A 498
ILE A 487
 None
 1.14A 3ko0M-5zxdA:
undetectable
3ko0N-5zxdA:
undetectable
3ko0O-5zxdA:
undetectable
3ko0P-5zxdA:
undetectable		 3ko0M-5zxdA:
undetectable
3ko0N-5zxdA:
undetectable
3ko0O-5zxdA:
undetectable
3ko0P-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 ASP A 386
SER A 333
LEU A 310
LEU A 329
ILE A 308
 None
 1.11A 3ko0M-6bbpA:
undetectable
3ko0N-6bbpA:
undetectable
3ko0O-6bbpA:
undetectable
3ko0P-6bbpA:
undetectable		 3ko0M-6bbpA:
20.56
3ko0N-6bbpA:
20.56
3ko0O-6bbpA:
20.56
3ko0P-6bbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
 None
 1.05A 3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable
3ko0O-6evjB:
undetectable
3ko0P-6evjB:
undetectable		 3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92
3ko0O-6evjB:
17.92
3ko0P-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 ASP A 874
GLU A 775
LEU A 772
ASP A 771
LEU A 802
 None
 1.24A 3ko0M-6fekA:
undetectable
3ko0N-6fekA:
undetectable
3ko0O-6fekA:
undetectable
3ko0P-6fekA:
undetectable		 3ko0M-6fekA:
23.53
3ko0N-6fekA:
23.53
3ko0O-6fekA:
23.53
3ko0P-6fekA:
23.53