SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_O_TFPO201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		4 GLY A 292
CYH A 251
PHE A 212
GLY A 101
 None
 0.97A 3ko0O-1c7gA:
undetectable
3ko0Q-1c7gA:
0.0		 3ko0O-1c7gA:
12.00
3ko0Q-1c7gA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 PHE A 296
PHE A 345
GLY A 242
PHE A 415
 None
 0.99A 3ko0O-1crlA:
2.6
3ko0Q-1crlA:
1.7		 3ko0O-1crlA:
10.30
3ko0Q-1crlA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 GLY A 395
PHE A 457
GLY A 427
PHE A 430
 HEO  A1002 (-3.3A)
None
None
None
 0.79A 3ko0O-1fftA:
undetectable
3ko0Q-1fftA:
0.3		 3ko0O-1fftA:
8.57
3ko0Q-1fftA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY B 308
PHE B 305
GLY B 284
PHE B 269
 None
 0.95A 3ko0O-1h4vB:
1.3
3ko0Q-1h4vB:
1.2		 3ko0O-1h4vB:
13.86
3ko0Q-1h4vB:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLY A 970
CYH A 871
PHE A 870
PHE A1174
 None
 0.92A 3ko0O-1ofeA:
undetectable
3ko0Q-1ofeA:
0.0		 3ko0O-1ofeA:
6.25
3ko0Q-1ofeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		4 GLY A 387
PHE A 449
GLY A 419
PHE A 422
 HEA  A 602 (-3.3A)
None
None
None
 0.64A 3ko0O-1qleA:
undetectable
3ko0Q-1qleA:
0.1		 3ko0O-1qleA:
10.65
3ko0Q-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 GLY A 254
PHE A 237
PHE A 240
PHE A 226
 None
 0.65A 3ko0O-1qnrA:
undetectable
3ko0Q-1qnrA:
undetectable		 3ko0O-1qnrA:
13.95
3ko0Q-1qnrA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 GLY A 183
PHE A 439
PHE A 440
GLY A 150
 None
None
SO4  A 593 (-4.5A)
I40  A 997 (-3.9A)
 0.94A 3ko0O-1qonA:
1.1
3ko0Q-1qonA:
0.0		 3ko0O-1qonA:
13.01
3ko0Q-1qonA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5s MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Mus musculus) 		PF02149
(KA1) 		4 GLY A 122
CYH A  67
PHE A  97
PHE A 107
 None
 0.85A 3ko0O-1v5sA:
undetectable
3ko0Q-1v5sA:
undetectable		 3ko0O-1v5sA:
23.26
3ko0Q-1v5sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		4 GLY A 194
PHE A 382
PHE A 146
GLY A 353
 None
None
None
ANP  A 400 (-3.0A)
 0.86A 3ko0O-1vpeA:
undetectable
3ko0Q-1vpeA:
undetectable		 3ko0O-1vpeA:
15.11
3ko0Q-1vpeA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 GLY A 218
PHE A  53
GLY A 263
PHE A 264
 None
 0.71A 3ko0O-1wacA:
0.6
3ko0Q-1wacA:
0.0		 3ko0O-1wacA:
9.91
3ko0Q-1wacA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		4 GLY A 292
PHE A  70
GLY A  55
PHE A  60
 None
 0.83A 3ko0O-1wz9A:
undetectable
3ko0Q-1wz9A:
0.0		 3ko0O-1wz9A:
14.44
3ko0Q-1wz9A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 456
PHE A 667
PHE A 460
GLY A 483
 None
 0.79A 3ko0O-1xfdA:
undetectable
3ko0Q-1xfdA:
undetectable		 3ko0O-1xfdA:
8.70
3ko0Q-1xfdA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 GLY A 110
MET A 138
CYH A 139
GLY A  25
 None
 0.97A 3ko0O-1yxmA:
undetectable
3ko0Q-1yxmA:
undetectable		 3ko0O-1yxmA:
16.10
3ko0Q-1yxmA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmf PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 GLY A 211
CYH A 297
GLY A 200
PHE A 189
 None
 0.99A 3ko0O-1zmfA:
undetectable
3ko0Q-1zmfA:
undetectable		 3ko0O-1zmfA:
19.21
3ko0Q-1zmfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLY A 160
CYH A 170
PHE A 173
GLY A 164
 None
None
None
ADP  A 901 (-3.1A)
 1.01A 3ko0O-1zxnA:
undetectable
3ko0Q-1zxnA:
undetectable		 3ko0O-1zxnA:
13.07
3ko0Q-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 GLY A  40
CYH A 153
GLY A  60
PHE A 124
 ACT  A 321 (-3.9A)
None
None
None
 0.99A 3ko0O-2ajrA:
undetectable
3ko0Q-2ajrA:
undetectable		 3ko0O-2ajrA:
16.01
3ko0Q-2ajrA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 GLY I 339
PHE I 123
PHE I 106
PHE I 108
 None
 0.83A 3ko0O-2b4xI:
undetectable
3ko0Q-2b4xI:
0.0		 3ko0O-2b4xI:
15.12
3ko0Q-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		4 CYH A  69
PHE A  71
GLY A 174
PHE A 240
 None
 0.85A 3ko0O-2bbvA:
undetectable
3ko0Q-2bbvA:
undetectable		 3ko0O-2bbvA:
12.11
3ko0Q-2bbvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 GLY A 183
CYH A 251
PHE A 266
GLY A 268
 5GP  A1340 ( 3.2A)
None
None
5GP  A1340 (-3.3A)
 0.89A 3ko0O-2bwgA:
undetectable
3ko0Q-2bwgA:
undetectable		 3ko0O-2bwgA:
13.22
3ko0Q-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Schistosoma
mansoni) 		PF00160
(Pro_isomerase) 		4 GLY A  82
CYH A 168
GLY A  71
PHE A  60
 None
 0.99A 3ko0O-2cmtA:
undetectable
3ko0Q-2cmtA:
undetectable		 3ko0O-2cmtA:
22.58
3ko0Q-2cmtA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		4 GLY A 356
PHE A 367
PHE A 165
GLY A 311
 None
 0.88A 3ko0O-2fgyA:
3.3
3ko0Q-2fgyA:
2.9		 3ko0O-2fgyA:
10.89
3ko0Q-2fgyA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 GLY A 154
CYH A 199
PHE A 196
GLY A 211
 None
 0.88A 3ko0O-2fpgA:
undetectable
3ko0Q-2fpgA:
undetectable		 3ko0O-2fpgA:
15.13
3ko0Q-2fpgA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 GLY B  43
CYH B  85
PHE B  77
PHE B 137
 None
 0.96A 3ko0O-2gmiB:
undetectable
3ko0Q-2gmiB:
undetectable		 3ko0O-2gmiB:
20.15
3ko0Q-2gmiB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 209
PHE A 319
GLY A 316
PHE A 315
 None
None
BHF  A 800 (-3.8A)
None
 1.00A 3ko0O-2hi4A:
undetectable
3ko0Q-2hi4A:
undetectable		 3ko0O-2hi4A:
12.50
3ko0Q-2hi4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ic7 MALTOSE
TRANSACETYLASE

(Geobacillus
kaustophilus) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		4 GLY A 141
PHE A  54
GLY A  87
PHE A  67
 None
 0.98A 3ko0O-2ic7A:
undetectable
3ko0Q-2ic7A:
undetectable		 3ko0O-2ic7A:
18.09
3ko0Q-2ic7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 130
PHE A 671
PHE A 762
GLY A  80
 SF4  A1984 (-3.6A)
None
None
None
 0.99A 3ko0O-2ivfA:
undetectable
3ko0Q-2ivfA:
undetectable		 3ko0O-2ivfA:
8.10
3ko0Q-2ivfA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A  42
PHE A 128
PHE A  77
GLY A  79
 None
 1.01A 3ko0O-2j1nA:
undetectable
3ko0Q-2j1nA:
undetectable		 3ko0O-2j1nA:
11.85
3ko0Q-2j1nA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 347
PHE A 342
GLY A 179
PHE A 180
 None
 0.90A 3ko0O-2nqlA:
undetectable
3ko0Q-2nqlA:
undetectable		 3ko0O-2nqlA:
13.65
3ko0Q-2nqlA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 348
PHE A 343
GLY A 180
PHE A 181
 None
 0.81A 3ko0O-2ppgA:
undetectable
3ko0Q-2ppgA:
undetectable		 3ko0O-2ppgA:
12.56
3ko0Q-2ppgA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt5 GLUTAMATE
RECEPTOR-INTERACTING
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 MET A 220
PHE A 162
GLY A 163
PHE A 164
 EDO  A   1 (-3.6A)
EDO  A   1 (-4.9A)
None
EDO  A   1 (-4.3A)
 0.97A 3ko0O-2qt5A:
undetectable
3ko0Q-2qt5A:
undetectable		 3ko0O-2qt5A:
19.00
3ko0Q-2qt5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		4 GLY A 173
CYH A  82
PHE A  83
GLY A 189
 None
 0.99A 3ko0O-2w1vA:
undetectable
3ko0Q-2w1vA:
undetectable		 3ko0O-2w1vA:
18.91
3ko0Q-2w1vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wst PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00541
(Adeno_knob) 		4 GLY A 152
PHE A 266
GLY A 286
PHE A 285
 None
 0.80A 3ko0O-2wstA:
undetectable
3ko0Q-2wstA:
undetectable		 3ko0O-2wstA:
14.55
3ko0Q-2wstA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A  42
PHE A 128
PHE A  77
GLY A  79
 None
 0.98A 3ko0O-2xe5A:
undetectable
3ko0Q-2xe5A:
undetectable		 3ko0O-2xe5A:
15.74
3ko0Q-2xe5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PHE A 109
PHE A 434
GLY A 433
PHE A 113
 None
 0.97A 3ko0O-2yfhA:
0.3
3ko0Q-2yfhA:
undetectable		 3ko0O-2yfhA:
12.47
3ko0Q-2yfhA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 GLY A 367
PHE A 238
GLY A   7
PHE A 296
 None
 0.86A 3ko0O-2zktA:
undetectable
3ko0Q-2zktA:
undetectable		 3ko0O-2zktA:
12.71
3ko0Q-2zktA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 GLY A 368
PHE A 238
GLY A   7
PHE A 296
 None
 0.96A 3ko0O-2zktA:
undetectable
3ko0Q-2zktA:
undetectable		 3ko0O-2zktA:
12.71
3ko0Q-2zktA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 GLY A 174
PHE A 257
GLY A 258
PHE A 259
 None
 1.01A 3ko0O-3bb7A:
undetectable
3ko0Q-3bb7A:
undetectable		 3ko0O-3bb7A:
15.26
3ko0Q-3bb7A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE

(Lactobacillus
plantarum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A  16
MET A 185
PHE A 172
PHE A 169
 NAD  A 400 (-3.3A)
None
NAD  A 400 (-4.4A)
None
 0.88A 3ko0O-3ceaA:
undetectable
3ko0Q-3ceaA:
undetectable		 3ko0O-3ceaA:
15.03
3ko0Q-3ceaA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3

(Campylobacter
jejuni) 		PF13531
(SBP_bac_11) 		4 PHE A 243
PHE A  71
GLY A  72
PHE A 215
 None
 0.93A 3ko0O-3fj7A:
undetectable
3ko0Q-3fj7A:
undetectable		 3ko0O-3fj7A:
18.80
3ko0Q-3fj7A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		4 GLY A 345
CYH A 177
PHE A 133
GLY A 199
 None
 0.87A 3ko0O-3hbzA:
undetectable
3ko0Q-3hbzA:
undetectable		 3ko0O-3hbzA:
14.96
3ko0Q-3hbzA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxz GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		4 GLY A 169
PHE A 142
PHE A 133
PHE A 181
 None
 0.98A 3ko0O-3lxzA:
undetectable
3ko0Q-3lxzA:
undetectable		 3ko0O-3lxzA:
19.65
3ko0Q-3lxzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2s NADPH-DEPENDENT
NITRO/FLAVIN
REDUCTASE

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		4 GLY A  50
PHE A  79
GLY A 160
PHE A 159
 None
None
None
FMN  A 400 ( 4.8A)
 0.95A 3ko0O-3n2sA:
undetectable
3ko0Q-3n2sA:
undetectable		 3ko0O-3n2sA:
16.67
3ko0Q-3n2sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 GLY A 193
MET A 278
PHE A 283
GLY A 269
 AMP  A 577 ( 3.7A)
None
None
None
 0.77A 3ko0O-3nyoA:
2.4
3ko0Q-3nyoA:
3.1		 3ko0O-3nyoA:
13.49
3ko0Q-3nyoA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 GLY A 209
PHE A 132
GLY A 187
PHE A 183
 None
 0.99A 3ko0O-3ptkA:
undetectable
3ko0Q-3ptkA:
undetectable		 3ko0O-3ptkA:
11.90
3ko0Q-3ptkA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 GLY A 204
CYH A 231
PHE A 232
GLY A 181
 None
 0.73A 3ko0O-3r0zA:
undetectable
3ko0Q-3r0zA:
undetectable		 3ko0O-3r0zA:
12.10
3ko0Q-3r0zA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 GLY A 620
PHE A 610
GLY A 564
PHE A 565
 None
 0.87A 3ko0O-3r75A:
undetectable
3ko0Q-3r75A:
undetectable		 3ko0O-3r75A:
9.91
3ko0Q-3r75A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 GLY M  24
PHE N 366
GLY M 114
PHE M 115
 None
 0.97A 3ko0O-3rkoM:
undetectable
3ko0Q-3rkoM:
undetectable		 3ko0O-3rkoM:
11.37
3ko0Q-3rkoM:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		4 GLY A 303
CYH A 374
PHE A 391
GLY A 309
 None
 0.97A 3ko0O-3tbfA:
undetectable
3ko0Q-3tbfA:
undetectable		 3ko0O-3tbfA:
15.08
3ko0Q-3tbfA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		4 GLY A 157
CYH A 248
PHE A 247
PHE A 216
 G6Q  A 571 ( 3.3A)
None
None
None
 0.95A 3ko0O-3ujhA:
1.3
3ko0Q-3ujhA:
1.4		 3ko0O-3ujhA:
9.95
3ko0Q-3ujhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 355
PHE A 340
PHE A 411
GLY A 409
 None
 0.99A 3ko0O-3vnsA:
undetectable
3ko0Q-3vnsA:
undetectable		 3ko0O-3vnsA:
10.42
3ko0Q-3vnsA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 374
CYH A 173
GLY A 339
PHE A 190
 None
 0.97A 3ko0O-3wd8A:
undetectable
3ko0Q-3wd8A:
undetectable		 3ko0O-3wd8A:
14.36
3ko0Q-3wd8A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfl BETA-MANNANASE

(Talaromyces
trachyspermus) 		PF00150
(Cellulase) 		4 GLY A 287
PHE A 270
PHE A 273
PHE A 259
 None
 0.66A 3ko0O-3wflA:
undetectable
3ko0Q-3wflA:
undetectable		 3ko0O-3wflA:
13.24
3ko0Q-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 262
PHE A  65
GLY A  88
PHE A  89
 None
 0.91A 3ko0O-3x1bA:
undetectable
3ko0Q-3x1bA:
undetectable		 3ko0O-3x1bA:
10.60
3ko0Q-3x1bA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		4 GLY A 254
PHE A 237
PHE A 240
PHE A 226
 None
 0.71A 3ko0O-3zizA:
undetectable
3ko0Q-3zizA:
undetectable		 3ko0O-3zizA:
11.52
3ko0Q-3zizA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 GLY A 709
PHE A 455
GLY A 762
PHE A 763
 None
 0.98A 3ko0O-4bq4A:
undetectable
3ko0Q-4bq4A:
undetectable		 3ko0O-4bq4A:
8.30
3ko0Q-4bq4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		4 GLY A 427
PHE A 387
PHE A 383
GLY A 424
 None
 0.95A 3ko0O-4doeA:
undetectable
3ko0Q-4doeA:
undetectable		 3ko0O-4doeA:
10.38
3ko0Q-4doeA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		4 GLY A  82
CYH A 168
GLY A  71
PHE A  60
 None
 1.00A 3ko0O-4e1qA:
undetectable
3ko0Q-4e1qA:
undetectable		 3ko0O-4e1qA:
17.26
3ko0Q-4e1qA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		4 PHE A 310
PHE A 324
GLY A 335
PHE A 334
 None
 0.94A 3ko0O-4fe9A:
undetectable
3ko0Q-4fe9A:
undetectable		 3ko0O-4fe9A:
11.54
3ko0Q-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 GLY A 292
PHE A  70
PHE A  58
PHE A  60
 None
 1.01A 3ko0O-4ga7A:
undetectable
3ko0Q-4ga7A:
undetectable		 3ko0O-4ga7A:
14.47
3ko0Q-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 4 GLY B 155
PHE B 263
GLY B 286
PHE B 268
 None
 0.72A 3ko0O-4gt2B:
undetectable
3ko0Q-4gt2B:
undetectable		 3ko0O-4gt2B:
13.55
3ko0Q-4gt2B:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt6 CELL SURFACE PROTEIN

(Faecalibacterium
prausnitzii) 		PF13306
(LRR_5) 		4 GLY A  81
CYH A 139
PHE A 138
GLY A 132
 None
 0.96A 3ko0O-4gt6A:
undetectable
3ko0Q-4gt6A:
undetectable		 3ko0O-4gt6A:
14.72
3ko0Q-4gt6A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		4 GLY A  89
PHE A 382
PHE A 384
GLY A  58
 None
 0.89A 3ko0O-4gz7A:
undetectable
3ko0Q-4gz7A:
undetectable		 3ko0O-4gz7A:
11.25
3ko0Q-4gz7A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA
ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		4 GLY B 304
MET A 329
PHE A 105
GLY B 310
 None
None
EDO  B 902 (-4.6A)
None
 0.96A 3ko0O-4hdsB:
undetectable
3ko0Q-4hdsB:
undetectable		 3ko0O-4hdsB:
13.26
3ko0Q-4hdsB:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		4 GLY A  82
CYH A 168
GLY A  71
PHE A  60
 None
 0.98A 3ko0O-4hy7A:
undetectable
3ko0Q-4hy7A:
undetectable		 3ko0O-4hy7A:
21.12
3ko0Q-4hy7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		4 GLY A 465
PHE A 519
GLY A 472
PHE A 506
 None
 1.00A 3ko0O-4impA:
undetectable
3ko0Q-4impA:
undetectable		 3ko0O-4impA:
10.55
3ko0Q-4impA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Citrus sinensis) 		PF00160
(Pro_isomerase) 		4 GLY A  82
CYH A 168
GLY A  71
PHE A  60
 None
 1.00A 3ko0O-4jjmA:
undetectable
3ko0Q-4jjmA:
undetectable		 3ko0O-4jjmA:
20.12
3ko0Q-4jjmA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 GLY A  87
PHE A 334
GLY A 101
PHE A 100
 None
 0.97A 3ko0O-4lvqA:
undetectable
3ko0Q-4lvqA:
undetectable		 3ko0O-4lvqA:
17.16
3ko0Q-4lvqA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 PHE A 217
PHE A 234
GLY A 210
PHE A 209
 None
 0.88A 3ko0O-4madA:
undetectable
3ko0Q-4madA:
undetectable		 3ko0O-4madA:
9.00
3ko0Q-4madA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		4 GLY A 156
PHE A 195
GLY A 152
PHE A 151
 None
 0.89A 3ko0O-4mlgA:
undetectable
3ko0Q-4mlgA:
undetectable		 3ko0O-4mlgA:
15.26
3ko0Q-4mlgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhx UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF11958
(DUF3472)
PF16871
(DUF5077) 		4 PHE A 305
PHE A 216
GLY A 198
PHE A 197
 None
None
PEG  A 518 (-4.6A)
None
 0.96A 3ko0O-4qhxA:
undetectable
3ko0Q-4qhxA:
undetectable		 3ko0O-4qhxA:
13.59
3ko0Q-4qhxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqr 3,5-EPIMERASE/4-REDU
CTASE

(Arabidopsis
thaliana) 		PF04321
(RmlD_sub_bind) 		4 GLY A 225
PHE A 139
GLY A 130
PHE A 131
 None
 1.00A 3ko0O-4qqrA:
undetectable
3ko0Q-4qqrA:
undetectable		 3ko0O-4qqrA:
14.01
3ko0Q-4qqrA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgi UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF13619
(KTSC) 		4 GLY A  70
PHE A  56
GLY A  31
PHE A  27
 None
 0.87A 3ko0O-4rgiA:
undetectable
3ko0Q-4rgiA:
undetectable		 3ko0O-4rgiA:
20.59
3ko0Q-4rgiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 GLY A 293
PHE A 544
PHE A 123
GLY A 587
 None
 0.89A 3ko0O-4uw2A:
undetectable
3ko0Q-4uw2A:
undetectable		 3ko0O-4uw2A:
9.22
3ko0Q-4uw2A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 393
PHE A 606
PHE A 398
GLY A 421
 None
 0.97A 3ko0O-4wjlA:
undetectable
3ko0Q-4wjlA:
undetectable		 3ko0O-4wjlA:
8.90
3ko0Q-4wjlA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		4 GLY A 192
PHE A 147
PHE A 195
PHE A 206
 None
 0.86A 3ko0O-4xdqA:
undetectable
3ko0Q-4xdqA:
undetectable		 3ko0O-4xdqA:
14.87
3ko0Q-4xdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ail POLY [ADP-RIBOSE]
POLYMERASE 9

(Homo sapiens) 		PF01661
(Macro) 		4 GLY A 311
PHE A 431
PHE A 444
GLY A 398
 None
 0.88A 3ko0O-5ailA:
undetectable
3ko0Q-5ailA:
undetectable		 3ko0O-5ailA:
19.13
3ko0Q-5ailA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 GLY A 133
PHE A 170
GLY A 140
PHE A 143
 None
None
None
56S  A 305 ( 3.5A)
 0.76A 3ko0O-5d1rA:
undetectable
3ko0Q-5d1rA:
undetectable		 3ko0O-5d1rA:
17.07
3ko0Q-5d1rA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 GLY A 496
PHE A 403
GLY A 468
PHE A 371
 None
 0.77A 3ko0O-5d79A:
undetectable
3ko0Q-5d79A:
undetectable		 3ko0O-5d79A:
12.05
3ko0Q-5d79A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 242
PHE A  44
GLY A  67
PHE A  68
 None
None
CU  A 509 ( 4.9A)
None
 0.93A 3ko0O-5ehfA:
undetectable
3ko0Q-5ehfA:
undetectable		 3ko0O-5ehfA:
11.27
3ko0Q-5ehfA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		4 GLY A 327
PHE A 116
PHE A 102
PHE A 104
 None
 0.81A 3ko0O-5ei0A:
undetectable
3ko0Q-5ei0A:
undetectable		 3ko0O-5ei0A:
13.45
3ko0Q-5ei0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		4 CYH A 239
PHE A 242
PHE A 190
GLY A 154
 None
 0.63A 3ko0O-5exeA:
undetectable
3ko0Q-5exeA:
undetectable		 3ko0O-5exeA:
11.84
3ko0Q-5exeA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY B 335
PHE B  12
GLY B 283
PHE B  74
 None
 0.97A 3ko0O-5fwxB:
undetectable
3ko0Q-5fwxB:
undetectable		 3ko0O-5fwxB:
12.79
3ko0Q-5fwxB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 GLY A 197
PHE A 240
GLY A 193
PHE A 192
 ACT  A 405 (-3.4A)
None
None
None
 0.92A 3ko0O-5gllA:
undetectable
3ko0Q-5gllA:
undetectable		 3ko0O-5gllA:
10.47
3ko0Q-5gllA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		4 GLY A  50
PHE A  79
GLY A 160
PHE A 159
 None
None
None
FMN  A 400 ( 4.6A)
 0.95A 3ko0O-5hdjA:
undetectable
3ko0Q-5hdjA:
undetectable		 3ko0O-5hdjA:
17.13
3ko0Q-5hdjA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3) 		4 GLY A 362
PHE A 390
GLY A 365
PHE A 366
 None
 0.95A 3ko0O-5hdmA:
undetectable
3ko0Q-5hdmA:
undetectable		 3ko0O-5hdmA:
15.70
3ko0Q-5hdmA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		4 GLY A 157
PHE A 225
GLY A  87
PHE A  88
 NAG  A 401 ( 4.2A)
None
None
None
 0.92A 3ko0O-5kenA:
undetectable
3ko0Q-5kenA:
undetectable		 3ko0O-5kenA:
15.50
3ko0Q-5kenA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		4 GLY A 319
PHE A  97
PHE A  41
GLY A  79
 None
 0.77A 3ko0O-5knnA:
undetectable
3ko0Q-5knnA:
undetectable		 3ko0O-5knnA:
13.11
3ko0Q-5knnA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN
PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
PF08084
(PROCT) 		4 GLY B2103
PHE A1319
PHE B2245
GLY B2244
 None
 0.91A 3ko0O-5m59B:
undetectable
3ko0Q-5m59B:
undetectable		 3ko0O-5m59B:
16.30
3ko0Q-5m59B:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		4 GLY A 155
PHE A 263
GLY A 286
PHE A 268
 None
 0.69A 3ko0O-5mapA:
undetectable
3ko0Q-5mapA:
undetectable		 3ko0O-5mapA:
15.99
3ko0Q-5mapA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 4 GLY A  99
PHE A 392
PHE A 394
GLY A  68
 GLY  A  99 ( 0.0A)
PHE  A 392 ( 1.3A)
PHE  A 394 ( 1.3A)
GLY  A  68 ( 0.0A)
 0.90A 3ko0O-5nksA:
undetectable
3ko0Q-5nksA:
undetectable		 3ko0O-5nksA:
11.01
3ko0Q-5nksA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 PHE A 533
PHE A 486
GLY A 446
PHE A 576
 None
 0.81A 3ko0O-5nqaA:
undetectable
3ko0Q-5nqaA:
undetectable		 3ko0O-5nqaA:
22.88
3ko0Q-5nqaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 GLY B 298
PHE B 314
PHE B 301
PHE B 332
 None
 0.99A 3ko0O-5swiB:
undetectable
3ko0Q-5swiB:
undetectable		 3ko0O-5swiB:
10.84
3ko0Q-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 PHE B 314
PHE B 301
GLY B 331
PHE B 332
 None
 0.86A 3ko0O-5swiB:
undetectable
3ko0Q-5swiB:
undetectable		 3ko0O-5swiB:
10.84
3ko0Q-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCC

(Pseudomonas
protegens) 		PF06857
(ACP) 		4 GLY C  21
PHE C  63
GLY C  92
PHE C  93
 None
 0.80A 3ko0O-5vj1C:
undetectable
3ko0Q-5vj1C:
undetectable		 3ko0O-5vj1C:
22.02
3ko0Q-5vj1C:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE

(Aspergillus
niger) 		no annotation 4 PHE A  97
PHE A 446
GLY A 445
PHE A 101
 None
 0.94A 3ko0O-5xviA:
0.4
3ko0Q-5xviA:
undetectable		 3ko0O-5xviA:
24.30
3ko0Q-5xviA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 4 GLY A 472
CYH A 456
PHE A 455
GLY A 390
 None
 0.90A 3ko0O-6b0tA:
undetectable
3ko0Q-6b0tA:
undetectable		 3ko0O-6b0tA:
24.53
3ko0Q-6b0tA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 4 GLY A  25
PHE A  97
GLY A  98
PHE A 123
 None
 1.00A 3ko0O-6b2yA:
undetectable
3ko0Q-6b2yA:
undetectable		 3ko0O-6b2yA:
14.81
3ko0Q-6b2yA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y SUPPRESSOR OF
CYTOKINE SIGNALING 1
TYROSINE-PROTEIN
KINASE JAK1

(Gallus gallus;
Homo sapiens) 		no annotation 4 GLY B  82
PHE A1088
PHE A1046
GLY A1097
 None
 0.98A 3ko0O-6c7yB:
undetectable
3ko0Q-6c7yB:
undetectable		 3ko0O-6c7yB:
17.82
3ko0Q-6c7yB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 GLY A 513
PHE A 532
GLY A 505
PHE A 504
 None
 0.89A 3ko0O-6eksA:
undetectable
3ko0Q-6eksA:
undetectable		 3ko0O-6eksA:
9.31
3ko0Q-6eksA:
9.31