SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_N_TFPN202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b48 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A 177
SER A 176
PHE A 133
LEU A 170
ILE A 124
 None
 1.35A 3ko0K-1b48A:
0.3
3ko0L-1b48A:
0.3
3ko0M-1b48A:
0.3
3ko0N-1b48A:
undetectable		 3ko0K-1b48A:
17.94
3ko0L-1b48A:
17.94
3ko0M-1b48A:
17.94
3ko0N-1b48A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 ASP A 252
GLU A 343
LEU A 339
SER A 340
PHE A 344
 None
 1.13A 3ko0K-1ij5A:
7.0
3ko0L-1ij5A:
7.3
3ko0M-1ij5A:
7.1
3ko0N-1ij5A:
7.3		 3ko0K-1ij5A:
17.12
3ko0L-1ij5A:
17.12
3ko0M-1ij5A:
17.12
3ko0N-1ij5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 482
ASP A 439
LEU A 436
SER A 486
ILE A 423
 None
 1.14A 3ko0K-1pz3A:
undetectable
3ko0L-1pz3A:
undetectable
3ko0M-1pz3A:
undetectable
3ko0N-1pz3A:
undetectable		 3ko0K-1pz3A:
12.17
3ko0L-1pz3A:
12.17
3ko0M-1pz3A:
12.17
3ko0N-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 GLU A 117
ASP A 116
SER A 161
ILE A 119
PHE A 198
 None
 1.34A 3ko0K-1u08A:
0.0
3ko0L-1u08A:
undetectable
3ko0M-1u08A:
0.0
3ko0N-1u08A:
undetectable		 3ko0K-1u08A:
13.17
3ko0L-1u08A:
13.17
3ko0M-1u08A:
13.17
3ko0N-1u08A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v38 SAM-DOMAIN PROTEIN
SAMSN-1

(Mus musculus) 		PF07647
(SAM_2) 		5 SER A   6
GLU A  37
ASP A  40
LEU A  32
ILE A  15
 None
 1.41A 3ko0K-1v38A:
undetectable
3ko0L-1v38A:
undetectable
3ko0M-1v38A:
undetectable
3ko0N-1v38A:
undetectable		 3ko0K-1v38A:
20.37
3ko0L-1v38A:
20.37
3ko0M-1v38A:
20.37
3ko0N-1v38A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaz NSFL1 COFACTOR P47

(Rattus
norvegicus) 		PF08059
(SEP) 		5 ASP A  64
LEU A  16
SER A  22
PHE A  21
ILE A  43
 None
 1.50A 3ko0K-1vazA:
undetectable
3ko0L-1vazA:
undetectable
3ko0M-1vazA:
undetectable
3ko0N-1vazA:
undetectable		 3ko0K-1vazA:
23.15
3ko0L-1vazA:
23.15
3ko0M-1vazA:
23.15
3ko0N-1vazA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybi NON-TOXIN
HAEMAGGLUTININ HA34

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 SER A 135
PHE A 140
ASP A 121
LEU A 129
ILE A  82
 None
 1.33A 3ko0K-1ybiA:
undetectable
3ko0L-1ybiA:
undetectable
3ko0M-1ybiA:
undetectable
3ko0N-1ybiA:
undetectable		 3ko0K-1ybiA:
14.58
3ko0L-1ybiA:
14.58
3ko0M-1ybiA:
14.58
3ko0N-1ybiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ASP A  13
LEU A  25
SER A  24
ILE A  36
CYH A  10
 None
 1.18A 3ko0K-1zzmA:
0.0
3ko0L-1zzmA:
undetectable
3ko0M-1zzmA:
0.0
3ko0N-1zzmA:
undetectable		 3ko0K-1zzmA:
14.89
3ko0L-1zzmA:
14.89
3ko0M-1zzmA:
14.89
3ko0N-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		5 SER A 191
LEU A 207
SER A 186
ILE A  65
CYH A  97
 None
 1.34A 3ko0K-2dg2A:
undetectable
3ko0L-2dg2A:
undetectable
3ko0M-2dg2A:
undetectable
3ko0N-2dg2A:
undetectable		 3ko0K-2dg2A:
15.35
3ko0L-2dg2A:
15.35
3ko0M-2dg2A:
15.35
3ko0N-2dg2A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		5 SER A 162
LEU A 186
SER A 185
ILE A   3
PHE A  38
 None
 1.40A 3ko0K-2nuxA:
undetectable
3ko0L-2nuxA:
undetectable
3ko0M-2nuxA:
undetectable
3ko0N-2nuxA:
undetectable		 3ko0K-2nuxA:
16.38
3ko0L-2nuxA:
16.38
3ko0M-2nuxA:
16.38
3ko0N-2nuxA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qoj INTRON-ENCODED DNA
ENDONUCLEASE I-ANII

(Aspergillus
nidulans) 		PF00961
(LAGLIDADG_1) 		5 SER Z 205
PHE Z 187
LEU Z 216
PHE Z 215
ILE Z 145
 None
 1.39A 3ko0K-2qojZ:
undetectable
3ko0L-2qojZ:
undetectable
3ko0M-2qojZ:
undetectable
3ko0N-2qojZ:
undetectable		 3ko0K-2qojZ:
17.93
3ko0L-2qojZ:
17.93
3ko0M-2qojZ:
17.93
3ko0N-2qojZ:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.19A 3ko0K-2v26A:
1.5
3ko0L-2v26A:
undetectable
3ko0M-2v26A:
1.5
3ko0N-2v26A:
0.1		 3ko0K-2v26A:
9.24
3ko0L-2v26A:
9.24
3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 ASP A 141
ASP A 402
LEU A 363
ILE A 398
PHE A 107
 None
 1.22A 3ko0K-2wn4A:
undetectable
3ko0L-2wn4A:
undetectable
3ko0M-2wn4A:
undetectable
3ko0N-2wn4A:
undetectable		 3ko0K-2wn4A:
13.10
3ko0L-2wn4A:
13.10
3ko0M-2wn4A:
13.10
3ko0N-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		5 SER Y  71
LEU Y  61
SER Y  63
PHE Y  62
ILE Y 192
 None
 1.46A 3ko0K-2zqpY:
undetectable
3ko0L-2zqpY:
undetectable
3ko0M-2zqpY:
undetectable
3ko0N-2zqpY:
undetectable		 3ko0K-2zqpY:
11.03
3ko0L-2zqpY:
11.03
3ko0M-2zqpY:
11.03
3ko0N-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		5 SER A 227
PHE A 182
LEU A 107
PHE A 149
ILE A 136
 None
 1.30A 3ko0K-3ayrA:
undetectable
3ko0L-3ayrA:
undetectable
3ko0M-3ayrA:
undetectable
3ko0N-3ayrA:
undetectable		 3ko0K-3ayrA:
14.80
3ko0L-3ayrA:
14.80
3ko0M-3ayrA:
14.80
3ko0N-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 ASP A 164
SER A 171
PHE A 410
ILE A 395
PHE A 298
 None
 1.15A 3ko0K-3eafA:
undetectable
3ko0L-3eafA:
undetectable
3ko0M-3eafA:
undetectable
3ko0N-3eafA:
undetectable		 3ko0K-3eafA:
12.92
3ko0L-3eafA:
12.92
3ko0M-3eafA:
12.92
3ko0N-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 ASP A 311
LEU A 336
SER A 337
PHE A 335
ILE A 332
 None
 1.49A 3ko0K-3hjeA:
0.6
3ko0L-3hjeA:
0.6
3ko0M-3hjeA:
0.6
3ko0N-3hjeA:
0.6		 3ko0K-3hjeA:
9.66
3ko0L-3hjeA:
9.66
3ko0M-3hjeA:
9.66
3ko0N-3hjeA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 ASP A 172
PHE A 240
LEU A 181
SER A 178
ILE A  68
 None
 1.20A 3ko0K-3hwpA:
undetectable
3ko0L-3hwpA:
undetectable
3ko0M-3hwpA:
undetectable
3ko0N-3hwpA:
undetectable		 3ko0K-3hwpA:
15.77
3ko0L-3hwpA:
15.77
3ko0M-3hwpA:
15.77
3ko0N-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 ASP A 229
LEU A 289
SER A 285
PHE A 288
ILE A 251
 FE  A 334 (-3.1A)
None
None
None
None
 1.27A 3ko0K-3ktcA:
undetectable
3ko0L-3ktcA:
undetectable
3ko0M-3ktcA:
undetectable
3ko0N-3ktcA:
undetectable		 3ko0K-3ktcA:
16.22
3ko0L-3ktcA:
16.22
3ko0M-3ktcA:
16.22
3ko0N-3ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb6 INTERLEUKIN-13

(Homo sapiens) 		PF03487
(IL13) 		5 GLU A  49
LEU A  83
SER A  82
ILE A  37
PHE A  70
 None
 1.36A 3ko0K-3lb6A:
undetectable
3ko0L-3lb6A:
undetectable
3ko0M-3lb6A:
undetectable
3ko0N-3lb6A:
undetectable		 3ko0K-3lb6A:
21.58
3ko0L-3lb6A:
21.58
3ko0M-3lb6A:
21.58
3ko0N-3lb6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 ASP A 205
LEU A 212
SER A 213
PHE A 211
ILE A 208
 None
None
None
None
DTD  A 248 ( 4.1A)
 1.22A 3ko0K-3oqvA:
undetectable
3ko0L-3oqvA:
undetectable
3ko0M-3oqvA:
undetectable
3ko0N-3oqvA:
undetectable		 3ko0K-3oqvA:
15.73
3ko0L-3oqvA:
15.73
3ko0M-3oqvA:
15.73
3ko0N-3oqvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 ASP A 238
GLU A 379
ASP A 375
LEU A 370
ILE A 138
 None
MG  A 700 ( 4.5A)
None
None
None
 1.50A 3ko0K-3r75A:
undetectable
3ko0L-3r75A:
undetectable
3ko0M-3r75A:
undetectable
3ko0N-3r75A:
undetectable		 3ko0K-3r75A:
9.91
3ko0L-3r75A:
9.91
3ko0M-3r75A:
9.91
3ko0N-3r75A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ASP A 344
LEU A 332
PHE A 331
ILE A 314
PHE A 293
 None
 1.38A 3ko0K-3rreA:
0.0
3ko0L-3rreA:
undetectable
3ko0M-3rreA:
0.0
3ko0N-3rreA:
undetectable		 3ko0K-3rreA:
11.38
3ko0L-3rreA:
11.38
3ko0M-3rreA:
11.38
3ko0N-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 GLU A 247
ASP A 246
LEU A 249
ILE A 182
CYH A 180
 None
 1.29A 3ko0K-3tbhA:
0.0
3ko0L-3tbhA:
undetectable
3ko0M-3tbhA:
0.0
3ko0N-3tbhA:
undetectable		 3ko0K-3tbhA:
13.77
3ko0L-3tbhA:
13.77
3ko0M-3tbhA:
13.77
3ko0N-3tbhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 SER A 260
PHE A 291
LEU A 242
SER A 188
ILE A 236
 None
 1.44A 3ko0K-3upyA:
undetectable
3ko0L-3upyA:
undetectable
3ko0M-3upyA:
undetectable
3ko0N-3upyA:
undetectable		 3ko0K-3upyA:
12.68
3ko0L-3upyA:
12.68
3ko0M-3upyA:
12.68
3ko0N-3upyA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 SER A 260
PHE A 291
SER A 188
ILE A 236
CYH A 172
 None
 1.35A 3ko0K-3upyA:
undetectable
3ko0L-3upyA:
undetectable
3ko0M-3upyA:
undetectable
3ko0N-3upyA:
undetectable		 3ko0K-3upyA:
12.68
3ko0L-3upyA:
12.68
3ko0M-3upyA:
12.68
3ko0N-3upyA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ASP A 325
LEU A 334
PHE A 333
ILE A 236
PHE A 264
 None
 1.16A 3ko0K-3wnpA:
undetectable
3ko0L-3wnpA:
undetectable
3ko0M-3wnpA:
undetectable
3ko0N-3wnpA:
undetectable		 3ko0K-3wnpA:
9.04
3ko0L-3wnpA:
9.04
3ko0M-3wnpA:
9.04
3ko0N-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrv TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		5 ASP A 163
SER A 162
LEU A 103
ILE A  14
PHE A 167
 None
 1.44A 3ko0K-3wrvA:
undetectable
3ko0L-3wrvA:
undetectable
3ko0M-3wrvA:
undetectable
3ko0N-3wrvA:
undetectable		 3ko0K-3wrvA:
20.00
3ko0L-3wrvA:
20.00
3ko0M-3wrvA:
20.00
3ko0N-3wrvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrv TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		5 ASP A 163
SER A 162
LEU A 107
ILE A  14
PHE A 167
 None
 1.28A 3ko0K-3wrvA:
undetectable
3ko0L-3wrvA:
undetectable
3ko0M-3wrvA:
undetectable
3ko0N-3wrvA:
undetectable		 3ko0K-3wrvA:
20.00
3ko0L-3wrvA:
20.00
3ko0M-3wrvA:
20.00
3ko0N-3wrvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A 751
ASP A 748
LEU A 738
ILE A 769
PHE A 705
 None
 1.26A 3ko0K-4anjA:
undetectable
3ko0L-4anjA:
undetectable
3ko0M-4anjA:
undetectable
3ko0N-4anjA:
undetectable		 3ko0K-4anjA:
6.93
3ko0L-4anjA:
6.93
3ko0M-4anjA:
6.93
3ko0N-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ASP A 363
SER A 361
LEU A  99
SER A  62
ILE A  73
 None
 1.40A 3ko0K-4ay1A:
undetectable
3ko0L-4ay1A:
undetectable
3ko0M-4ay1A:
undetectable
3ko0N-4ay1A:
undetectable		 3ko0K-4ay1A:
13.70
3ko0L-4ay1A:
13.70
3ko0M-4ay1A:
13.70
3ko0N-4ay1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 ASP A 351
ASP A 318
LEU A 332
PHE A 327
ILE A 325
 None
 1.24A 3ko0K-4bhdA:
undetectable
3ko0L-4bhdA:
undetectable
3ko0M-4bhdA:
undetectable
3ko0N-4bhdA:
undetectable		 3ko0K-4bhdA:
12.38
3ko0L-4bhdA:
12.38
3ko0M-4bhdA:
12.38
3ko0N-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 GLU A 221
LEU A 217
SER A 218
PHE A 222
ILE A 225
 None
 1.21A 3ko0K-4chlA:
undetectable
3ko0L-4chlA:
undetectable
3ko0M-4chlA:
undetectable
3ko0N-4chlA:
undetectable		 3ko0K-4chlA:
16.32
3ko0L-4chlA:
16.32
3ko0M-4chlA:
16.32
3ko0N-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 PHE A 126
ASP A 143
LEU A 109
SER A 107
PHE A 170
 None
 1.49A 3ko0K-4di5A:
0.6
3ko0L-4di5A:
0.5
3ko0M-4di5A:
0.5
3ko0N-4di5A:
0.5		 3ko0K-4di5A:
12.58
3ko0L-4di5A:
12.58
3ko0M-4di5A:
12.58
3ko0N-4di5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dth VGRG PROTEIN

(Vibrio cholerae) 		PF16671
(ACD) 		5 ASP A  87
LEU A 347
SER A 349
ILE A  13
CYH A  84
 None
 1.37A 3ko0K-4dthA:
undetectable
3ko0L-4dthA:
undetectable
3ko0M-4dthA:
undetectable
3ko0N-4dthA:
undetectable		 3ko0K-4dthA:
13.44
3ko0L-4dthA:
13.44
3ko0M-4dthA:
13.44
3ko0N-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 GLU A 214
LEU A 228
SER A 231
ILE A 288
PHE A 252
 None
 1.29A 3ko0K-4fidA:
undetectable
3ko0L-4fidA:
undetectable
3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable		 3ko0K-4fidA:
15.16
3ko0L-4fidA:
15.16
3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 PHE A 208
GLU A 214
LEU A 228
SER A 231
PHE A 252
 None
 1.19A 3ko0K-4fidA:
undetectable
3ko0L-4fidA:
undetectable
3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable		 3ko0K-4fidA:
15.16
3ko0L-4fidA:
15.16
3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA

(Thermotoga
maritima) 		no annotation 5 LEU D1018
SER D1009
PHE D1010
ILE D1047
PHE D1059
 None
 1.35A 3ko0K-4hluD:
undetectable
3ko0L-4hluD:
undetectable
3ko0M-4hluD:
undetectable
3ko0N-4hluD:
undetectable		 3ko0K-4hluD:
18.46
3ko0L-4hluD:
18.46
3ko0M-4hluD:
18.46
3ko0N-4hluD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ASP A 495
LEU A 596
ILE A 509
CYH A 512
PHE A 515
 1B2  A 802 (-3.6A)
None
None
None
None
 1.24A 3ko0K-4hwtA:
0.9
3ko0L-4hwtA:
1.1
3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1		 3ko0K-4hwtA:
14.49
3ko0L-4hwtA:
14.49
3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		5 GLU A  68
ASP A  67
LEU A 109
SER A 110
ILE A  72
 None
 1.48A 3ko0K-4ihqA:
undetectable
3ko0L-4ihqA:
undetectable
3ko0M-4ihqA:
undetectable
3ko0N-4ihqA:
undetectable		 3ko0K-4ihqA:
11.98
3ko0L-4ihqA:
11.98
3ko0M-4ihqA:
11.98
3ko0N-4ihqA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnd CTP
L-MYO-INOSITOL-1-PHO
SPHATE
CYTIDYLYLTRANSFERASE
/CDP-L-MYO-INOSITOL
MYO-INOSITOLPHOSPHOT
RANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf)
PF12804
(NTP_transf_3) 		5 ASP A 296
SER A 300
GLU A 362
SER A 308
ILE A 363
 None
 1.39A 3ko0K-4mndA:
undetectable
3ko0L-4mndA:
undetectable
3ko0M-4mndA:
undetectable
3ko0N-4mndA:
undetectable		 3ko0K-4mndA:
12.84
3ko0L-4mndA:
12.84
3ko0M-4mndA:
12.84
3ko0N-4mndA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 5 SER A 182
LEU A 270
SER A 266
ILE A 199
PHE A 155
 None
 1.48A 3ko0K-4n5aA:
1.6
3ko0L-4n5aA:
undetectable
3ko0M-4n5aA:
undetectable
3ko0N-4n5aA:
undetectable		 3ko0K-4n5aA:
11.95
3ko0L-4n5aA:
11.95
3ko0M-4n5aA:
11.95
3ko0N-4n5aA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		5 ASP A 171
LEU A 349
PHE A 344
ILE A 112
PHE A 168
 None
 1.29A 3ko0K-4o8vA:
undetectable
3ko0L-4o8vA:
undetectable
3ko0M-4o8vA:
undetectable
3ko0N-4o8vA:
undetectable		 3ko0K-4o8vA:
16.23
3ko0L-4o8vA:
16.23
3ko0M-4o8vA:
16.23
3ko0N-4o8vA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 SER A 189
LEU A 227
SER A 226
PHE A 238
ILE A 273
 None
 1.30A 3ko0K-4ojzA:
0.0
3ko0L-4ojzA:
undetectable
3ko0M-4ojzA:
0.0
3ko0N-4ojzA:
undetectable		 3ko0K-4ojzA:
8.97
3ko0L-4ojzA:
8.97
3ko0M-4ojzA:
8.97
3ko0N-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 PHE A  65
GLU A 132
LEU A  70
SER A  67
ILE A 292
 UNX  A 408 ( 4.8A)
UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
 1.23A 3ko0K-4pwyA:
undetectable
3ko0L-4pwyA:
undetectable
3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable		 3ko0K-4pwyA:
18.85
3ko0L-4pwyA:
18.85
3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 ASP A 346
SER A 363
PHE A 420
SER A 368
ILE A 413
 None
 1.20A 3ko0K-4u3tA:
undetectable
3ko0L-4u3tA:
undetectable
3ko0M-4u3tA:
undetectable
3ko0N-4u3tA:
undetectable		 3ko0K-4u3tA:
15.76
3ko0L-4u3tA:
15.76
3ko0M-4u3tA:
15.76
3ko0N-4u3tA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		5 ASP A 467
GLU A 261
ASP A 473
LEU A 262
SER A 258
 None
 1.45A 3ko0K-4upiA:
undetectable
3ko0L-4upiA:
undetectable
3ko0M-4upiA:
undetectable
3ko0N-4upiA:
undetectable		 3ko0K-4upiA:
10.66
3ko0L-4upiA:
10.66
3ko0M-4upiA:
10.66
3ko0N-4upiA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		5 ASP A 169
GLU A 356
ASP A 281
PHE A 355
ILE A 360
 None
None
None
EDO  A 403 ( 4.8A)
None
 1.31A 3ko0K-4wzzA:
undetectable
3ko0L-4wzzA:
undetectable
3ko0M-4wzzA:
undetectable
3ko0N-4wzzA:
undetectable		 3ko0K-4wzzA:
13.01
3ko0L-4wzzA:
13.01
3ko0M-4wzzA:
13.01
3ko0N-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		5 ASP A 172
SER A  49
GLU A  71
SER A  79
ILE A  94
 None
SAM  A1001 (-2.4A)
SAM  A1001 ( 4.4A)
SAM  A1001 (-2.7A)
None
 1.46A 3ko0K-4ymgA:
undetectable
3ko0L-4ymgA:
undetectable
3ko0M-4ymgA:
undetectable
3ko0N-4ymgA:
undetectable		 3ko0K-4ymgA:
18.38
3ko0L-4ymgA:
18.38
3ko0M-4ymgA:
18.38
3ko0N-4ymgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 ASP A 593
GLU A 724
LEU A 735
ILE A  21
PHE A 115
 None
 1.27A 3ko0K-5ah5A:
undetectable
3ko0L-5ah5A:
undetectable
3ko0M-5ah5A:
undetectable
3ko0N-5ah5A:
undetectable		 3ko0K-5ah5A:
7.86
3ko0L-5ah5A:
7.86
3ko0M-5ah5A:
7.86
3ko0N-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 ASP A 417
SER A 403
GLU A  23
LEU A  26
ILE A  61
 None
 1.19A 3ko0K-5cykA:
undetectable
3ko0L-5cykA:
undetectable
3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable		 3ko0K-5cykA:
10.91
3ko0L-5cykA:
10.91
3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.10A 3ko0K-5dwzC:
undetectable
3ko0L-5dwzC:
undetectable
3ko0M-5dwzC:
undetectable
3ko0N-5dwzC:
undetectable		 3ko0K-5dwzC:
14.11
3ko0L-5dwzC:
14.11
3ko0M-5dwzC:
14.11
3ko0N-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 SER A 164
LEU A  94
SER A  95
PHE A  69
ILE A  74
 None
 1.15A 3ko0K-5hyhA:
undetectable
3ko0L-5hyhA:
undetectable
3ko0M-5hyhA:
undetectable
3ko0N-5hyhA:
undetectable		 3ko0K-5hyhA:
14.19
3ko0L-5hyhA:
14.19
3ko0M-5hyhA:
14.19
3ko0N-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 ASP B 397
ASP B 376
LEU B 361
SER B 386
CYH B 381
 None
 1.16A 3ko0K-5hzgB:
undetectable
3ko0L-5hzgB:
undetectable
3ko0M-5hzgB:
undetectable
3ko0N-5hzgB:
undetectable		 3ko0K-5hzgB:
8.73
3ko0L-5hzgB:
8.73
3ko0M-5hzgB:
8.73
3ko0N-5hzgB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLU A 350
ASP A 351
LEU A 484
SER A 483
PHE A 487
 None
 1.10A 3ko0K-5iudA:
undetectable
3ko0L-5iudA:
undetectable
3ko0M-5iudA:
undetectable
3ko0N-5iudA:
undetectable		 3ko0K-5iudA:
7.87
3ko0L-5iudA:
7.87
3ko0M-5iudA:
7.87
3ko0N-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ASP A 346
SER A 363
PHE A 420
SER A 368
ILE A 413
 None
 1.22A 3ko0K-5kshA:
undetectable
3ko0L-5kshA:
undetectable
3ko0M-5kshA:
undetectable
3ko0N-5kshA:
undetectable		 3ko0K-5kshA:
10.70
3ko0L-5kshA:
10.70
3ko0M-5kshA:
10.70
3ko0N-5kshA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnb UBIQUITIN-LIKE-SPECI
FIC PROTEASE 2

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		5 ASP B  59
LEU B  91
PHE B 185
ILE B 182
CYH B 130
 None
 1.38A 3ko0K-5lnbB:
undetectable
3ko0L-5lnbB:
undetectable
3ko0M-5lnbB:
undetectable
3ko0N-5lnbB:
undetectable		 3ko0K-5lnbB:
16.50
3ko0L-5lnbB:
16.50
3ko0M-5lnbB:
16.50
3ko0N-5lnbB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 5 ASP A 799
SER A 766
GLU A 309
LEU A  65
ILE A  94
 None
None
None
CZA  A1002 (-4.1A)
None
 1.38A 3ko0K-5mpmA:
undetectable
3ko0L-5mpmA:
0.9
3ko0M-5mpmA:
undetectable
3ko0N-5mpmA:
undetectable		 3ko0K-5mpmA:
24.47
3ko0L-5mpmA:
24.47
3ko0M-5mpmA:
24.47
3ko0N-5mpmA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 SER A 153
GLU A 135
LEU A 132
SER A 172
PHE A 173
 None
 1.28A 3ko0K-5n6mA:
1.5
3ko0L-5n6mA:
undetectable
3ko0M-5n6mA:
1.6
3ko0N-5n6mA:
1.6		 3ko0K-5n6mA:
10.32
3ko0L-5n6mA:
10.32
3ko0M-5n6mA:
10.32
3ko0N-5n6mA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv5 FIC FAMILY PROTEIN

(Enterococcus
faecalis) 		no annotation 5 ASP A  38
PHE A 186
ASP A  41
LEU A  60
ILE A  56
 None
 1.43A 3ko0K-5nv5A:
undetectable
3ko0L-5nv5A:
undetectable
3ko0M-5nv5A:
undetectable
3ko0N-5nv5A:
0.6		 3ko0K-5nv5A:
24.04
3ko0L-5nv5A:
24.04
3ko0M-5nv5A:
24.04
3ko0N-5nv5A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Gloeobacter
violaceus;
Mus musculus) 		no annotation 5 SER A 240
PHE A 295
LEU A 401
ILE A 405
PHE A 288
 None
 1.42A 3ko0K-5osbA:
1.5
3ko0L-5osbA:
1.4
3ko0M-5osbA:
1.5
3ko0N-5osbA:
1.5		 3ko0K-5osbA:
15.94
3ko0L-5osbA:
15.94
3ko0M-5osbA:
15.94
3ko0N-5osbA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ASP A 262
ASP A 103
LEU A 111
PHE A 120
ILE A  95
 None
 1.49A 3ko0K-5uv2A:
undetectable
3ko0L-5uv2A:
1.3
3ko0M-5uv2A:
0.2
3ko0N-5uv2A:
undetectable		 3ko0K-5uv2A:
11.99
3ko0L-5uv2A:
11.99
3ko0M-5uv2A:
11.99
3ko0N-5uv2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmb DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		no annotation 5 ASP A 640
PHE A 633
LEU A 316
PHE A 315
ILE A 627
 None
None
None
EDO  A 815 ( 4.8A)
None
 1.23A 3ko0K-5wmbA:
undetectable
3ko0L-5wmbA:
undetectable
3ko0M-5wmbA:
undetectable
3ko0N-5wmbA:
undetectable		 3ko0K-5wmbA:
13.36
3ko0L-5wmbA:
13.36
3ko0M-5wmbA:
13.36
3ko0N-5wmbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 5 SER B 241
PHE B 296
LEU B 331
ILE B 335
PHE B 289
 None
 1.33A 3ko0K-6d6uB:
undetectable
3ko0L-6d6uB:
1.8
3ko0M-6d6uB:
undetectable
3ko0N-6d6uB:
1.8		 3ko0K-6d6uB:
20.39
3ko0L-6d6uB:
20.39
3ko0M-6d6uB:
20.39
3ko0N-6d6uB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dub -

(-) 		no annotation 5 SER A  94
ASP A 122
LEU A 105
PHE A 104
ILE A 219
 None
SAH  A 301 ( 4.9A)
None
UNX  A 304 ( 4.8A)
None
 1.08A 3ko0K-6dubA:
undetectable
3ko0L-6dubA:
undetectable
3ko0M-6dubA:
undetectable
3ko0N-6dubA:
undetectable		 3ko0K-6dubA:
undetectable
3ko0L-6dubA:
undetectable
3ko0M-6dubA:
undetectable
3ko0N-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
 None
 1.13A 3ko0K-6evjB:
undetectable
3ko0L-6evjB:
undetectable
3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable		 3ko0K-6evjB:
17.92
3ko0L-6evjB:
17.92
3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92