SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_M_TFPM202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 LEU A 142
PHE A  86
ILE A  18
ASP A 145
SER A 130
 None
 1.13A 3ko0M-1ag9A:
undetectable
3ko0N-1ag9A:
undetectable
3ko0O-1ag9A:
undetectable
3ko0P-1ag9A:
undetectable		 3ko0M-1ag9A:
22.70
3ko0N-1ag9A:
22.70
3ko0O-1ag9A:
22.70
3ko0P-1ag9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czk FLAVODOXIN

(Synechococcus
elongatus) 		PF00258
(Flavodoxin_1) 		5 LEU A 141
PHE A  86
ILE A  17
ASP A 144
SER A 130
 None
 1.14A 3ko0M-1czkA:
undetectable
3ko0N-1czkA:
undetectable
3ko0O-1czkA:
undetectable
3ko0P-1czkA:
undetectable		 3ko0M-1czkA:
21.02
3ko0N-1czkA:
21.02
3ko0O-1czkA:
21.02
3ko0P-1czkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 SYNTAXIN 8
VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1

(Mus musculus;
Rattus
norvegicus) 		PF12352
(V-SNARE_C)
no annotation 		5 LEU C 167
ILE D 172
GLU D 175
LEU D 176
ASP D 177
 None
 1.19A 3ko0M-1gl2C:
undetectable
3ko0N-1gl2C:
undetectable
3ko0O-1gl2C:
undetectable
3ko0P-1gl2C:
undetectable		 3ko0M-1gl2C:
20.79
3ko0N-1gl2C:
20.79
3ko0O-1gl2C:
20.79
3ko0P-1gl2C:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		5 LEU A  82
PHE A  81
CYH A  99
LEU A 125
ASP A 116
 None
None
NAD  A1382 (-4.5A)
None
None
 1.14A 3ko0M-1gy8A:
undetectable
3ko0N-1gy8A:
undetectable
3ko0O-1gy8A:
undetectable
3ko0P-1gy8A:
undetectable		 3ko0M-1gy8A:
13.92
3ko0N-1gy8A:
13.92
3ko0O-1gy8A:
13.92
3ko0P-1gy8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 LEU A 339
SER A 340
PHE A 344
GLU A 343
ASP A 252
 None
 1.02A 3ko0M-1ij5A:
7.1
3ko0N-1ij5A:
7.3
3ko0O-1ij5A:
7.1
3ko0P-1ij5A:
7.1		 3ko0M-1ij5A:
17.12
3ko0N-1ij5A:
17.12
3ko0O-1ij5A:
17.12
3ko0P-1ij5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 LEU L 408
PHE L 502
ILE L 211
PHE L 497
LEU L 472
 None
 1.22A 3ko0M-1kfuL:
0.0
3ko0N-1kfuL:
3.8
3ko0O-1kfuL:
3.7
3ko0P-1kfuL:
3.8		 3ko0M-1kfuL:
11.01
3ko0N-1kfuL:
11.01
3ko0O-1kfuL:
11.01
3ko0P-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A  73
ILE A   9
GLU A  12
LEU A  13
ASP A  14
 None
 1.20A 3ko0M-1kyiA:
0.0
3ko0N-1kyiA:
undetectable
3ko0O-1kyiA:
undetectable
3ko0P-1kyiA:
undetectable		 3ko0M-1kyiA:
12.19
3ko0N-1kyiA:
12.19
3ko0O-1kyiA:
12.19
3ko0P-1kyiA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 LEU A 436
SER A 486
ILE A 423
ASP A 439
ASP A 482
 None
 1.14A 3ko0M-1pz3A:
undetectable
3ko0N-1pz3A:
undetectable
3ko0O-1pz3A:
undetectable
3ko0P-1pz3A:
undetectable		 3ko0M-1pz3A:
12.17
3ko0N-1pz3A:
12.17
3ko0O-1pz3A:
12.17
3ko0P-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A 296
SER A 297
PHE A 301
ILE A 304
LEU A 325
 None
 1.18A 3ko0M-1pztA:
undetectable
3ko0N-1pztA:
undetectable
3ko0O-1pztA:
undetectable
3ko0P-1pztA:
undetectable		 3ko0M-1pztA:
17.80
3ko0N-1pztA:
17.80
3ko0O-1pztA:
17.80
3ko0P-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A  32
PHE A  29
ILE A 108
LEU A  64
ASP A  24
 None
 1.22A 3ko0M-1q3bA:
0.3
3ko0N-1q3bA:
undetectable
3ko0O-1q3bA:
undetectable
3ko0P-1q3bA:
undetectable		 3ko0M-1q3bA:
17.05
3ko0N-1q3bA:
17.05
3ko0O-1q3bA:
17.05
3ko0P-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 LEU A 243
LEU A 110
ASP A 111
ASP A 277
SER A 280
 None
 0.95A 3ko0M-1vp4A:
0.0
3ko0N-1vp4A:
undetectable
3ko0O-1vp4A:
undetectable
3ko0P-1vp4A:
undetectable		 3ko0M-1vp4A:
13.44
3ko0N-1vp4A:
13.44
3ko0O-1vp4A:
13.44
3ko0P-1vp4A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		5 LEU A  68
SER A  69
ILE A  64
LEU A  31
ASP A  32
 None
None
None
POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
 1.10A 3ko0M-1wozA:
0.8
3ko0N-1wozA:
undetectable
3ko0O-1wozA:
undetectable
3ko0P-1wozA:
undetectable		 3ko0M-1wozA:
20.57
3ko0N-1wozA:
20.57
3ko0O-1wozA:
20.57
3ko0P-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 285
SER A 266
ILE A 301
PHE A 224
LEU A 303
 None
 1.14A 3ko0M-1x9eA:
0.0
3ko0N-1x9eA:
undetectable
3ko0O-1x9eA:
undetectable
3ko0P-1x9eA:
undetectable		 3ko0M-1x9eA:
14.44
3ko0N-1x9eA:
14.44
3ko0O-1x9eA:
14.44
3ko0P-1x9eA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 177
SER A 178
PHE A 182
ILE A 185
GLU A 181
 None
 1.16A 3ko0M-1ykwA:
undetectable
3ko0N-1ykwA:
undetectable
3ko0O-1ykwA:
undetectable
3ko0P-1ykwA:
undetectable		 3ko0M-1ykwA:
12.47
3ko0N-1ykwA:
12.47
3ko0O-1ykwA:
12.47
3ko0P-1ykwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbp HYPOTHETICAL PROTEIN
VPA1032

(Vibrio
parahaemolyticus) 		PF07024
(ImpE) 		5 LEU A 104
SER A 106
PHE A 107
ILE A 126
LEU A 100
 None
 1.05A 3ko0M-1zbpA:
undetectable
3ko0N-1zbpA:
undetectable
3ko0O-1zbpA:
undetectable
3ko0P-1zbpA:
undetectable		 3ko0M-1zbpA:
17.49
3ko0N-1zbpA:
17.49
3ko0O-1zbpA:
17.49
3ko0P-1zbpA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 LEU A  25
SER A  24
ILE A  36
CYH A  10
ASP A  13
 None
 1.18A 3ko0M-1zzmA:
0.0
3ko0N-1zzmA:
undetectable
3ko0O-1zzmA:
undetectable
3ko0P-1zzmA:
undetectable		 3ko0M-1zzmA:
14.89
3ko0N-1zzmA:
14.89
3ko0O-1zzmA:
14.89
3ko0P-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 SER A 154
PHE A 156
ILE A 331
LEU A 151
SER A 186
 None
 1.17A 3ko0M-2c4kA:
undetectable
3ko0N-2c4kA:
undetectable
3ko0O-2c4kA:
undetectable
3ko0P-2c4kA:
undetectable		 3ko0M-2c4kA:
12.83
3ko0N-2c4kA:
12.83
3ko0O-2c4kA:
12.83
3ko0P-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A 175
ILE A  55
PHE A   7
LEU A  59
SER A 168
 None
 1.14A 3ko0M-2e0iA:
0.0
3ko0N-2e0iA:
undetectable
3ko0O-2e0iA:
undetectable
3ko0P-2e0iA:
undetectable		 3ko0M-2e0iA:
12.59
3ko0N-2e0iA:
12.59
3ko0O-2e0iA:
12.59
3ko0P-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A 130
SER A 128
PHE A 129
ILE A 317
LEU A 288
 None
 0.90A 3ko0M-2fqxA:
undetectable
3ko0N-2fqxA:
undetectable
3ko0O-2fqxA:
undetectable
3ko0P-2fqxA:
undetectable		 3ko0M-2fqxA:
13.92
3ko0N-2fqxA:
13.92
3ko0O-2fqxA:
13.92
3ko0P-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 LEU A 156
SER A 157
ILE A 164
GLU A 160
LEU A 134
 None
 1.19A 3ko0M-2ghiA:
undetectable
3ko0N-2ghiA:
undetectable
3ko0O-2ghiA:
undetectable
3ko0P-2ghiA:
undetectable		 3ko0M-2ghiA:
17.14
3ko0N-2ghiA:
17.14
3ko0O-2ghiA:
17.14
3ko0P-2ghiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 SER A 166
PHE A 168
ILE A 344
LEU A 163
SER A 198
 CL  A1369 (-3.8A)
None
None
None
None
 1.22A 3ko0M-2ji4A:
undetectable
3ko0N-2ji4A:
undetectable
3ko0O-2ji4A:
undetectable
3ko0P-2ji4A:
undetectable		 3ko0M-2ji4A:
14.12
3ko0N-2ji4A:
14.12
3ko0O-2ji4A:
14.12
3ko0P-2ji4A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 910
PHE A 909
ILE A 888
CYH A 892
LEU A 845
 None
 1.00A 3ko0M-2ogvA:
undetectable
3ko0N-2ogvA:
undetectable
3ko0O-2ogvA:
undetectable
3ko0P-2ogvA:
undetectable		 3ko0M-2ogvA:
15.41
3ko0N-2ogvA:
15.41
3ko0O-2ogvA:
15.41
3ko0P-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		5 LEU A 180
SER A 181
LEU A 155
ASP A 154
SER A 190
 None
 1.21A 3ko0M-2p0lA:
undetectable
3ko0N-2p0lA:
undetectable
3ko0O-2p0lA:
undetectable
3ko0P-2p0lA:
undetectable		 3ko0M-2p0lA:
18.68
3ko0N-2p0lA:
18.68
3ko0O-2p0lA:
18.68
3ko0P-2p0lA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmu RESPONSE REGULATOR
PHOP

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		5 LEU A 174
SER A 175
PHE A 179
GLU A 178
LEU A 221
 None
 1.23A 3ko0M-2pmuA:
undetectable
3ko0N-2pmuA:
undetectable
3ko0O-2pmuA:
undetectable
3ko0P-2pmuA:
undetectable		 3ko0M-2pmuA:
19.82
3ko0N-2pmuA:
19.82
3ko0O-2pmuA:
19.82
3ko0P-2pmuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 SER A 190
ILE A 325
LEU A 217
ASP A 218
PHE A 128
 None
 0.96A 3ko0M-2qzxA:
undetectable
3ko0N-2qzxA:
undetectable
3ko0O-2qzxA:
undetectable
3ko0P-2qzxA:
undetectable		 3ko0M-2qzxA:
17.17
3ko0N-2qzxA:
17.17
3ko0O-2qzxA:
17.17
3ko0P-2qzxA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.14A 3ko0M-2v26A:
undetectable
3ko0N-2v26A:
undetectable
3ko0O-2v26A:
undetectable
3ko0P-2v26A:
undetectable		 3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
3ko0O-2v26A:
9.24
3ko0P-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 363
ILE A 398
PHE A 107
ASP A 402
ASP A 141
 None
 1.15A 3ko0M-2wn4A:
undetectable
3ko0N-2wn4A:
undetectable
3ko0O-2wn4A:
undetectable
3ko0P-2wn4A:
undetectable		 3ko0M-2wn4A:
13.10
3ko0N-2wn4A:
13.10
3ko0O-2wn4A:
13.10
3ko0P-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		5 LEU A  96
SER A  94
ILE A  99
SER A 315
PHE A 360
 None
 1.23A 3ko0M-2zwaA:
undetectable
3ko0N-2zwaA:
undetectable
3ko0O-2zwaA:
undetectable
3ko0P-2zwaA:
undetectable		 3ko0M-2zwaA:
9.21
3ko0N-2zwaA:
9.21
3ko0O-2zwaA:
9.21
3ko0P-2zwaA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU B  68
SER B  70
PHE B  71
LEU B 106
PHE B  85
 None
HEM  B 401 ( 3.8A)
None
HEM  B 401 ( 4.5A)
None
 1.19A 3ko0M-3a0gB:
undetectable
3ko0N-3a0gB:
undetectable
3ko0O-3a0gB:
undetectable
3ko0P-3a0gB:
undetectable		 3ko0M-3a0gB:
21.92
3ko0N-3a0gB:
21.92
3ko0O-3a0gB:
21.92
3ko0P-3a0gB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 356
ILE A 391
PHE A 100
ASP A 395
ASP A 134
 None
 1.19A 3ko0M-3buzA:
undetectable
3ko0N-3buzA:
undetectable
3ko0O-3buzA:
undetectable
3ko0P-3buzA:
undetectable		 3ko0M-3buzA:
12.71
3ko0N-3buzA:
12.71
3ko0O-3buzA:
12.71
3ko0P-3buzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 SER X 239
ILE X 278
PHE X 259
ASP X  18
SER X  11
 None
 1.23A 3ko0M-3e13X:
undetectable
3ko0N-3e13X:
undetectable
3ko0O-3e13X:
undetectable
3ko0P-3e13X:
undetectable		 3ko0M-3e13X:
16.67
3ko0N-3e13X:
16.67
3ko0O-3e13X:
16.67
3ko0P-3e13X:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 SER A 171
PHE A 410
ILE A 395
PHE A 298
ASP A 164
 None
 1.18A 3ko0M-3eafA:
undetectable
3ko0N-3eafA:
undetectable
3ko0O-3eafA:
undetectable
3ko0P-3eafA:
undetectable		 3ko0M-3eafA:
12.92
3ko0N-3eafA:
12.92
3ko0O-3eafA:
12.92
3ko0P-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 146
ILE A 122
CYH A 133
PHE A 132
LEU A 154
 None
 1.21A 3ko0M-3fkdA:
undetectable
3ko0N-3fkdA:
undetectable
3ko0O-3fkdA:
undetectable
3ko0P-3fkdA:
undetectable		 3ko0M-3fkdA:
12.82
3ko0N-3fkdA:
12.82
3ko0O-3fkdA:
12.82
3ko0P-3fkdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.12A 3ko0M-3h11A:
undetectable
3ko0N-3h11A:
undetectable
3ko0O-3h11A:
undetectable
3ko0P-3h11A:
undetectable		 3ko0M-3h11A:
15.79
3ko0N-3h11A:
15.79
3ko0O-3h11A:
15.79
3ko0P-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 LEU A 133
SER A 130
ILE A 403
LEU A 380
ASP A 379
 None
 1.13A 3ko0M-3hq2A:
undetectable
3ko0N-3hq2A:
undetectable
3ko0O-3hq2A:
undetectable
3ko0P-3hq2A:
undetectable		 3ko0M-3hq2A:
12.15
3ko0N-3hq2A:
12.15
3ko0O-3hq2A:
12.15
3ko0P-3hq2A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 5 LEU A 181
SER A 178
ILE A  68
ASP A 172
PHE A 240
 None
 1.16A 3ko0M-3hwpA:
undetectable
3ko0N-3hwpA:
undetectable
3ko0O-3hwpA:
undetectable
3ko0P-3hwpA:
undetectable		 3ko0M-3hwpA:
15.77
3ko0N-3hwpA:
15.77
3ko0O-3hwpA:
15.77
3ko0P-3hwpA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 416
ILE A 408
LEU A 437
ASP A 436
PHE A 381
 None
None
None
NDG  A4701 ( 3.1A)
None
 1.14A 3ko0M-3i2tA:
undetectable
3ko0N-3i2tA:
undetectable
3ko0O-3i2tA:
undetectable
3ko0P-3i2tA:
undetectable		 3ko0M-3i2tA:
11.34
3ko0N-3i2tA:
11.34
3ko0O-3i2tA:
11.34
3ko0P-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 LEU A  19
PHE A  48
LEU A 115
ASP A 101
SER A  25
 None
 1.17A 3ko0M-3jr3A:
undetectable
3ko0N-3jr3A:
undetectable
3ko0O-3jr3A:
undetectable
3ko0P-3jr3A:
undetectable		 3ko0M-3jr3A:
20.18
3ko0N-3jr3A:
20.18
3ko0O-3jr3A:
20.18
3ko0P-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		5 LEU A 170
PHE A 147
ILE A 103
LEU A  79
ASP A 142
 None
 1.19A 3ko0M-3k4zA:
undetectable
3ko0N-3k4zA:
undetectable
3ko0O-3k4zA:
undetectable
3ko0P-3k4zA:
undetectable		 3ko0M-3k4zA:
16.07
3ko0N-3k4zA:
16.07
3ko0O-3k4zA:
16.07
3ko0P-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kby PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10804
(DUF2538) 		5 SER A 113
PHE A 110
ILE A 109
GLU A 103
ASP A 106
 None
 1.07A 3ko0M-3kbyA:
undetectable
3ko0N-3kbyA:
undetectable
3ko0O-3kbyA:
undetectable
3ko0P-3kbyA:
undetectable		 3ko0M-3kbyA:
21.13
3ko0N-3kbyA:
21.13
3ko0O-3kbyA:
21.13
3ko0P-3kbyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 166
SER A 169
PHE A 170
LEU A 272
SER A 203
 None
 0.93A 3ko0M-3mjoA:
1.0
3ko0N-3mjoA:
undetectable
3ko0O-3mjoA:
0.8
3ko0P-3mjoA:
1.0		 3ko0M-3mjoA:
17.12
3ko0N-3mjoA:
17.12
3ko0O-3mjoA:
17.12
3ko0P-3mjoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		5 LEU A 249
PHE A 311
LEU A 172
ASP A 258
PHE A  83
 None
 1.12A 3ko0M-3n8uA:
undetectable
3ko0N-3n8uA:
undetectable
3ko0O-3n8uA:
undetectable
3ko0P-3n8uA:
undetectable		 3ko0M-3n8uA:
14.11
3ko0N-3n8uA:
14.11
3ko0O-3n8uA:
14.11
3ko0P-3n8uA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		5 LEU B  37
ILE B  48
LEU B  79
ASP B  80
PHE B  11
 None
HEM  B1087 ( 4.4A)
None
None
None
 1.20A 3ko0M-3ph2B:
undetectable
3ko0N-3ph2B:
undetectable
3ko0O-3ph2B:
undetectable
3ko0P-3ph2B:
undetectable		 3ko0M-3ph2B:
19.00
3ko0N-3ph2B:
19.00
3ko0O-3ph2B:
19.00
3ko0P-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 203
ILE A 169
LEU A 223
ASP A 222
PHE A 253
 None
 1.20A 3ko0M-3skvA:
undetectable
3ko0N-3skvA:
undetectable
3ko0O-3skvA:
undetectable
3ko0P-3skvA:
undetectable		 3ko0M-3skvA:
14.71
3ko0N-3skvA:
14.71
3ko0O-3skvA:
14.71
3ko0P-3skvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 LEU A 431
ILE A 262
LEU A 435
ASP A 436
PHE A 777
 None
None
None
None
EDO  A 795 ( 3.6A)
 0.82A 3ko0M-3tbkA:
undetectable
3ko0N-3tbkA:
undetectable
3ko0O-3tbkA:
undetectable
3ko0P-3tbkA:
undetectable		 3ko0M-3tbkA:
10.99
3ko0N-3tbkA:
10.99
3ko0O-3tbkA:
10.99
3ko0P-3tbkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj7 GBAA_1210 PROTEIN

(Bacillus
anthracis) 		PF01928
(CYTH) 		5 LEU A  45
SER A  43
ILE A 108
GLU A  39
LEU A 113
 None
 1.19A 3ko0M-3tj7A:
undetectable
3ko0N-3tj7A:
undetectable
3ko0O-3tj7A:
undetectable
3ko0P-3tj7A:
undetectable		 3ko0M-3tj7A:
19.49
3ko0N-3tj7A:
19.49
3ko0O-3tj7A:
19.49
3ko0P-3tj7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		5 LEU A 324
SER A 321
ILE A 293
LEU A 260
ASP A 132
 None
 1.22A 3ko0M-3uduA:
undetectable
3ko0N-3uduA:
undetectable
3ko0O-3uduA:
undetectable
3ko0P-3uduA:
undetectable		 3ko0M-3uduA:
16.22
3ko0N-3uduA:
16.22
3ko0O-3uduA:
16.22
3ko0P-3uduA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 LEU A 334
PHE A 333
ILE A 236
PHE A 264
ASP A 325
 None
 1.10A 3ko0M-3wnpA:
undetectable
3ko0N-3wnpA:
undetectable
3ko0O-3wnpA:
undetectable
3ko0P-3wnpA:
undetectable		 3ko0M-3wnpA:
9.04
3ko0N-3wnpA:
9.04
3ko0O-3wnpA:
9.04
3ko0P-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		5 LEU A 281
PHE A 284
ILE A 334
LEU A 336
ASP A 337
 None
 1.14A 3ko0M-3wvsA:
undetectable
3ko0N-3wvsA:
undetectable
3ko0O-3wvsA:
undetectable
3ko0P-3wvsA:
undetectable		 3ko0M-3wvsA:
12.56
3ko0N-3wvsA:
12.56
3ko0O-3wvsA:
12.56
3ko0P-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 LEU A 738
ILE A 769
PHE A 705
ASP A 748
PHE A 751
 None
 1.22A 3ko0M-4anjA:
undetectable
3ko0N-4anjA:
undetectable
3ko0O-4anjA:
undetectable
3ko0P-4anjA:
undetectable		 3ko0M-4anjA:
6.93
3ko0N-4anjA:
6.93
3ko0O-4anjA:
6.93
3ko0P-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.89A 3ko0M-4ay2A:
undetectable
3ko0N-4ay2A:
undetectable
3ko0O-4ay2A:
undetectable
3ko0P-4ay2A:
undetectable		 3ko0M-4ay2A:
9.75
3ko0N-4ay2A:
9.75
3ko0O-4ay2A:
9.75
3ko0P-4ay2A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		5 LEU A 332
PHE A 327
ILE A 325
ASP A 318
ASP A 351
 None
 1.20A 3ko0M-4bhdA:
undetectable
3ko0N-4bhdA:
undetectable
3ko0O-4bhdA:
undetectable
3ko0P-4bhdA:
undetectable		 3ko0M-4bhdA:
12.38
3ko0N-4bhdA:
12.38
3ko0O-4bhdA:
12.38
3ko0P-4bhdA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 LEU A 217
SER A 218
PHE A 222
ILE A 225
GLU A 221
 None
 1.13A 3ko0M-4chlA:
undetectable
3ko0N-4chlA:
undetectable
3ko0O-4chlA:
undetectable
3ko0P-4chlA:
undetectable		 3ko0M-4chlA:
16.32
3ko0N-4chlA:
16.32
3ko0O-4chlA:
16.32
3ko0P-4chlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		5 LEU A 318
PHE A 316
ILE A 301
LEU A 258
ASP A 387
 None
 1.22A 3ko0M-4dj2A:
undetectable
3ko0N-4dj2A:
undetectable
3ko0O-4dj2A:
undetectable
3ko0P-4dj2A:
undetectable		 3ko0M-4dj2A:
15.71
3ko0N-4dj2A:
15.71
3ko0O-4dj2A:
15.71
3ko0P-4dj2A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		5 LEU A 138
SER A 134
ILE A 141
LEU A 183
ASP A 184
 None
 1.16A 3ko0M-4f53A:
undetectable
3ko0N-4f53A:
undetectable
3ko0O-4f53A:
undetectable
3ko0P-4f53A:
undetectable		 3ko0M-4f53A:
10.94
3ko0N-4f53A:
10.94
3ko0O-4f53A:
10.94
3ko0P-4f53A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 228
SER A 231
ILE A 288
PHE A 252
GLU A 214
 None
 1.22A 3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable
3ko0O-4fidA:
undetectable
3ko0P-4fidA:
undetectable		 3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
3ko0O-4fidA:
15.16
3ko0P-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 228
SER A 231
PHE A 252
GLU A 214
PHE A 208
 None
 1.13A 3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable
3ko0O-4fidA:
undetectable
3ko0P-4fidA:
undetectable		 3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
3ko0O-4fidA:
15.16
3ko0P-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		5 LEU A  49
SER A  47
ILE A  66
LEU A  61
ASP A  60
 None
 1.13A 3ko0M-4g09A:
undetectable
3ko0N-4g09A:
undetectable
3ko0O-4g09A:
undetectable
3ko0P-4g09A:
undetectable		 3ko0M-4g09A:
12.13
3ko0N-4g09A:
12.13
3ko0O-4g09A:
12.13
3ko0P-4g09A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 5 LEU H 138
SER H 139
ILE H  88
LEU H  84
PHE H 244
 None
 1.11A 3ko0M-4he8H:
0.9
3ko0N-4he8H:
undetectable
3ko0O-4he8H:
undetectable
3ko0P-4he8H:
undetectable		 3ko0M-4he8H:
13.81
3ko0N-4he8H:
13.81
3ko0O-4he8H:
13.81
3ko0P-4he8H:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.22A 3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1
3ko0O-4hwtA:
1.0
3ko0P-4hwtA:
0.8		 3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
3ko0O-4hwtA:
14.49
3ko0P-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 1.01A 3ko0M-4iggA:
undetectable
3ko0N-4iggA:
undetectable
3ko0O-4iggA:
undetectable
3ko0P-4iggA:
undetectable		 3ko0M-4iggA:
9.16
3ko0N-4iggA:
9.16
3ko0O-4iggA:
9.16
3ko0P-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A  45
PHE A  66
ILE A  11
LEU A 240
ASP A 241
 None
 1.16A 3ko0M-4iwmA:
undetectable
3ko0N-4iwmA:
undetectable
3ko0O-4iwmA:
undetectable
3ko0P-4iwmA:
undetectable		 3ko0M-4iwmA:
17.05
3ko0N-4iwmA:
17.05
3ko0O-4iwmA:
17.05
3ko0P-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		5 LEU A 235
ILE A  98
LEU A 108
ASP A 109
SER A 353
 None
 0.86A 3ko0M-4j1lA:
undetectable
3ko0N-4j1lA:
undetectable
3ko0O-4j1lA:
undetectable
3ko0P-4j1lA:
undetectable		 3ko0M-4j1lA:
14.29
3ko0N-4j1lA:
14.29
3ko0O-4j1lA:
14.29
3ko0P-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 LEU A 152
SER A 150
PHE A 151
ILE A  30
PHE A  38
 None
 1.12A 3ko0M-4jhiA:
undetectable
3ko0N-4jhiA:
undetectable
3ko0O-4jhiA:
undetectable
3ko0P-4jhiA:
undetectable		 3ko0M-4jhiA:
18.29
3ko0N-4jhiA:
18.29
3ko0O-4jhiA:
18.29
3ko0P-4jhiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 LEU A1524
SER A1523
ILE A1481
LEU A1480
ASP A1476
 None
 1.20A 3ko0M-4lnzA:
1.7
3ko0N-4lnzA:
1.6
3ko0O-4lnzA:
1.7
3ko0P-4lnzA:
1.7		 3ko0M-4lnzA:
14.90
3ko0N-4lnzA:
14.90
3ko0O-4lnzA:
14.90
3ko0P-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.92A 3ko0M-4on9A:
undetectable
3ko0N-4on9A:
undetectable
3ko0O-4on9A:
undetectable
3ko0P-4on9A:
undetectable		 3ko0M-4on9A:
10.86
3ko0N-4on9A:
10.86
3ko0O-4on9A:
10.86
3ko0P-4on9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 LEU A  85
PHE A  92
ILE A  67
LEU A 129
PHE A 119
 None
 1.20A 3ko0M-4p53A:
undetectable
3ko0N-4p53A:
undetectable
3ko0O-4p53A:
undetectable
3ko0P-4p53A:
undetectable		 3ko0M-4p53A:
12.62
3ko0N-4p53A:
12.62
3ko0O-4p53A:
12.62
3ko0P-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 LEU A  70
SER A  67
ILE A 292
GLU A 132
PHE A  65
 None
UNX  A 420 ( 3.0A)
None
UNX  A 420 ( 3.3A)
UNX  A 408 ( 4.8A)
 1.18A 3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable
3ko0O-4pwyA:
undetectable
3ko0P-4pwyA:
undetectable		 3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
3ko0O-4pwyA:
18.85
3ko0P-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 390
ILE A 382
CYH A 409
LEU A 377
ASP A 405
 None
 1.00A 3ko0M-4r5dA:
undetectable
3ko0N-4r5dA:
undetectable
3ko0O-4r5dA:
undetectable
3ko0P-4r5dA:
undetectable		 3ko0M-4r5dA:
10.93
3ko0N-4r5dA:
10.93
3ko0O-4r5dA:
10.93
3ko0P-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		5 LEU A  37
ILE A  42
CYH A 161
GLU A 169
LEU A 173
 None
 1.20A 3ko0M-4r94A:
undetectable
3ko0N-4r94A:
undetectable
3ko0O-4r94A:
undetectable
3ko0P-4r94A:
undetectable		 3ko0M-4r94A:
16.86
3ko0N-4r94A:
16.86
3ko0O-4r94A:
16.86
3ko0P-4r94A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 LEU A  95
ILE A 120
LEU A 114
ASP A 113
PHE A 162
 None
 1.10A 3ko0M-4s1aA:
undetectable
3ko0N-4s1aA:
undetectable
3ko0O-4s1aA:
undetectable
3ko0P-4s1aA:
undetectable		 3ko0M-4s1aA:
18.98
3ko0N-4s1aA:
18.98
3ko0O-4s1aA:
18.98
3ko0P-4s1aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL

(Plasmodium
berghei) 		no annotation 5 PHE A 115
ILE A 138
CYH A 142
LEU A  57
ASP A  60
 None
 1.23A 3ko0M-4u5aA:
undetectable
3ko0N-4u5aA:
1.9
3ko0O-4u5aA:
1.9
3ko0P-4u5aA:
1.9		 3ko0M-4u5aA:
20.30
3ko0N-4u5aA:
20.30
3ko0O-4u5aA:
20.30
3ko0P-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 409
PHE A 408
ILE A 396
LEU A 400
ASP A 401
 None
 1.06A 3ko0M-4up7A:
undetectable
3ko0N-4up7A:
undetectable
3ko0O-4up7A:
undetectable
3ko0P-4up7A:
undetectable		 3ko0M-4up7A:
9.51
3ko0N-4up7A:
9.51
3ko0O-4up7A:
9.51
3ko0P-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		5 LEU A  14
ILE A   8
LEU A   6
ASP A  39
PHE A  65
 None
 1.20A 3ko0M-4wj0A:
undetectable
3ko0N-4wj0A:
undetectable
3ko0O-4wj0A:
undetectable
3ko0P-4wj0A:
undetectable		 3ko0M-4wj0A:
16.94
3ko0N-4wj0A:
16.94
3ko0O-4wj0A:
16.94
3ko0P-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 819
PHE A 818
ILE A 845
LEU A 856
ASP A 854
 None
 1.23A 3ko0M-4wz9A:
undetectable
3ko0N-4wz9A:
undetectable
3ko0O-4wz9A:
undetectable
3ko0P-4wz9A:
undetectable		 3ko0M-4wz9A:
9.13
3ko0N-4wz9A:
9.13
3ko0O-4wz9A:
9.13
3ko0P-4wz9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 LEU C 359
ILE C 590
CYH C 396
GLU C 592
LEU C 593
 None
 1.21A 3ko0M-4xgcC:
2.7
3ko0N-4xgcC:
2.6
3ko0O-4xgcC:
2.6
3ko0P-4xgcC:
2.7		 3ko0M-4xgcC:
8.97
3ko0N-4xgcC:
8.97
3ko0O-4xgcC:
8.97
3ko0P-4xgcC:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2842
SER A2844
PHE A2845
LEU A2830
ASP A2854
 None
 1.16A 3ko0M-4z37A:
undetectable
3ko0N-4z37A:
undetectable
3ko0O-4z37A:
undetectable
3ko0P-4z37A:
undetectable		 3ko0M-4z37A:
9.61
3ko0N-4z37A:
9.61
3ko0O-4z37A:
9.61
3ko0P-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 577
ILE A 573
LEU A 588
ASP A 587
PHE A 627
 None
 1.03A 3ko0M-4z61A:
undetectable
3ko0N-4z61A:
undetectable
3ko0O-4z61A:
undetectable
3ko0P-4z61A:
undetectable		 3ko0M-4z61A:
10.84
3ko0N-4z61A:
10.84
3ko0O-4z61A:
10.84
3ko0P-4z61A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 567
ILE A 563
LEU A 578
ASP A 577
PHE A 617
 None
 1.06A 3ko0M-4z64A:
undetectable
3ko0N-4z64A:
undetectable
3ko0O-4z64A:
undetectable
3ko0P-4z64A:
undetectable		 3ko0M-4z64A:
11.79
3ko0N-4z64A:
11.79
3ko0O-4z64A:
11.79
3ko0P-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 LEU A 126
PHE A 122
LEU A  56
ASP A  57
SER A  40
 None
None
None
None
DMS  A1314 ( 3.7A)
 1.15A 3ko0M-5advA:
undetectable
3ko0N-5advA:
undetectable
3ko0O-5advA:
undetectable
3ko0P-5advA:
undetectable		 3ko0M-5advA:
15.55
3ko0N-5advA:
15.55
3ko0O-5advA:
15.55
3ko0P-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 LEU A  50
SER A  51
ILE A  46
GLU A 106
LEU A 109
 None
 1.04A 3ko0M-5azdA:
1.7
3ko0N-5azdA:
1.7
3ko0O-5azdA:
1.7
3ko0P-5azdA:
1.8		 3ko0M-5azdA:
15.53
3ko0N-5azdA:
15.53
3ko0O-5azdA:
15.53
3ko0P-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU B 168
SER B  83
PHE B  82
LEU A 387
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.12A 3ko0M-5b8iB:
6.2
3ko0N-5b8iB:
6.2
3ko0O-5b8iB:
6.2
3ko0P-5b8iB:
6.3		 3ko0M-5b8iB:
19.54
3ko0N-5b8iB:
19.54
3ko0O-5b8iB:
19.54
3ko0P-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 LEU A  26
ILE A  61
GLU A  23
ASP A  64
ASP A 417
 None
 1.22A 3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable
3ko0O-5cykA:
undetectable
3ko0P-5cykA:
undetectable		 3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
3ko0O-5cykA:
10.91
3ko0P-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		5 LEU A  24
ILE A 277
GLU A 265
LEU A 261
ASP A 263
 None
 1.15A 3ko0M-5d86A:
undetectable
3ko0N-5d86A:
undetectable
3ko0O-5d86A:
undetectable
3ko0P-5d86A:
undetectable		 3ko0M-5d86A:
16.92
3ko0N-5d86A:
16.92
3ko0O-5d86A:
16.92
3ko0P-5d86A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 LEU A 112
PHE A 109
ILE A 127
LEU A 167
ASP A 214
 None
 1.20A 3ko0M-5frsA:
undetectable
3ko0N-5frsA:
undetectable
3ko0O-5frsA:
undetectable
3ko0P-5frsA:
undetectable		 3ko0M-5frsA:
8.68
3ko0N-5frsA:
8.68
3ko0O-5frsA:
8.68
3ko0P-5frsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 LEU A 230
ILE A 105
LEU A 271
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.04A 3ko0M-5hxsA:
undetectable
3ko0N-5hxsA:
undetectable
3ko0O-5hxsA:
undetectable
3ko0P-5hxsA:
undetectable		 3ko0M-5hxsA:
12.62
3ko0N-5hxsA:
12.62
3ko0O-5hxsA:
12.62
3ko0P-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 LEU A  94
SER A  95
PHE A  69
ILE A  74
SER A 164
 None
 1.04A 3ko0M-5hyhA:
undetectable
3ko0N-5hyhA:
undetectable
3ko0O-5hyhA:
undetectable
3ko0P-5hyhA:
undetectable		 3ko0M-5hyhA:
14.19
3ko0N-5hyhA:
14.19
3ko0O-5hyhA:
14.19
3ko0P-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A 484
SER A 483
PHE A 487
GLU A 350
ASP A 351
 None
 1.15A 3ko0M-5iudA:
undetectable
3ko0N-5iudA:
undetectable
3ko0O-5iudA:
undetectable
3ko0P-5iudA:
undetectable		 3ko0M-5iudA:
7.87
3ko0N-5iudA:
7.87
3ko0O-5iudA:
7.87
3ko0P-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		5 LEU A 182
LEU A 184
ASP A 185
ASP A  56
SER A  94
 None
None
6MB  A 301 (-3.2A)
None
None
 1.22A 3ko0M-5jq9A:
undetectable
3ko0N-5jq9A:
undetectable
3ko0O-5jq9A:
undetectable
3ko0P-5jq9A:
undetectable		 3ko0M-5jq9A:
15.16
3ko0N-5jq9A:
15.16
3ko0O-5jq9A:
15.16
3ko0P-5jq9A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 143
SER B 134
ILE B 183
LEU B 164
ASP B 138
 None
 1.08A 3ko0M-5k1cB:
undetectable
3ko0N-5k1cB:
undetectable
3ko0O-5k1cB:
undetectable
3ko0P-5k1cB:
undetectable		 3ko0M-5k1cB:
9.96
3ko0N-5k1cB:
9.96
3ko0O-5k1cB:
9.96
3ko0P-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 368
ILE A 413
ASP A 346
SER A 363
PHE A 420
 None
 1.23A 3ko0M-5kshA:
undetectable
3ko0N-5kshA:
undetectable
3ko0O-5kshA:
undetectable
3ko0P-5kshA:
undetectable		 3ko0M-5kshA:
10.70
3ko0N-5kshA:
10.70
3ko0O-5kshA:
10.70
3ko0P-5kshA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU B 102
ILE B  99
LEU B 123
ASP B 122
SER B 112
 None
 1.18A 3ko0M-5l3sB:
undetectable
3ko0N-5l3sB:
undetectable
3ko0O-5l3sB:
undetectable
3ko0P-5l3sB:
undetectable		 3ko0M-5l3sB:
14.58
3ko0N-5l3sB:
14.58
3ko0O-5l3sB:
14.58
3ko0P-5l3sB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 5 LEU A 428
PHE A 427
LEU A 320
ASP A 319
SER A 290
 None
 1.11A 3ko0M-5m3xA:
undetectable
3ko0N-5m3xA:
undetectable
3ko0O-5m3xA:
undetectable
3ko0P-5m3xA:
undetectable		 3ko0M-5m3xA:
21.74
3ko0N-5m3xA:
21.74
3ko0O-5m3xA:
21.74
3ko0P-5m3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 5 LEU A 129
ILE A 104
LEU A 107
ASP A 108
PHE A  75
 None
 1.13A 3ko0M-5ubvA:
undetectable
3ko0N-5ubvA:
undetectable
3ko0O-5ubvA:
undetectable
3ko0P-5ubvA:
undetectable		 3ko0M-5ubvA:
21.05
3ko0N-5ubvA:
21.05
3ko0O-5ubvA:
21.05
3ko0P-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxv SENSORY TRANSDUCTION
REGULATORY PROTEIN

(Bartonella
quintana) 		no annotation 5 LEU A 127
PHE A  99
ILE A 102
ASP A  65
SER A  89
 None
 1.02A 3ko0M-5uxvA:
undetectable
3ko0N-5uxvA:
undetectable
3ko0O-5uxvA:
undetectable
3ko0P-5uxvA:
undetectable		 3ko0M-5uxvA:
17.59
3ko0N-5uxvA:
17.59
3ko0O-5uxvA:
17.59
3ko0P-5uxvA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A1347
SER A1348
ILE A1355
LEU A1325
ASP A1378
 None
ATP  A1501 ( 4.2A)
None
None
None
 1.22A 3ko0M-5w81A:
undetectable
3ko0N-5w81A:
1.1
3ko0O-5w81A:
undetectable
3ko0P-5w81A:
undetectable		 3ko0M-5w81A:
5.55
3ko0N-5w81A:
5.55
3ko0O-5w81A:
5.55
3ko0P-5w81A:
5.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 SER B 145
ILE B 150
LEU B 111
ASP B 109
ASP B  72
 None
 1.12A 3ko0M-5y3rB:
undetectable
3ko0N-5y3rB:
undetectable
3ko0O-5y3rB:
undetectable
3ko0P-5y3rB:
undetectable		 3ko0M-5y3rB:
11.39
3ko0N-5y3rB:
11.39
3ko0O-5y3rB:
11.39
3ko0P-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 LEU A 329
ILE A 308
LEU A 310
ASP A 386
SER A 333
 None
 1.20A 3ko0M-6bbpA:
undetectable
3ko0N-6bbpA:
undetectable
3ko0O-6bbpA:
undetectable
3ko0P-6bbpA:
undetectable		 3ko0M-6bbpA:
20.56
3ko0N-6bbpA:
20.56
3ko0O-6bbpA:
20.56
3ko0P-6bbpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 LEU A 271
SER A 270
ILE A 277
LEU A 337
ASP A 356
 None
 1.18A 3ko0M-6cc2A:
undetectable
3ko0N-6cc2A:
undetectable
3ko0O-6cc2A:
undetectable
3ko0P-6cc2A:
undetectable		 3ko0M-6cc2A:
16.67
3ko0N-6cc2A:
16.67
3ko0O-6cc2A:
16.67
3ko0P-6cc2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
 None
 1.01A 3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable
3ko0O-6evjB:
undetectable
3ko0P-6evjB:
undetectable		 3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92
3ko0O-6evjB:
17.92
3ko0P-6evjB:
17.92