SIMILAR PATTERNS OF AMINO ACIDS FOR 3KO0_L_TFPL202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgn ICEBERG (PROTEASE
INHIBITOR)

(Homo sapiens) 		PF00619
(CARD) 		5 LEU A   5
ASP A   3
LEU A  89
ILE A  73
CYH A  69
 None
 1.17A 3ko0K-1dgnA:
undetectable
3ko0L-1dgnA:
undetectable
3ko0M-1dgnA:
undetectable
3ko0N-1dgnA:
undetectable		 3ko0K-1dgnA:
25.71
3ko0L-1dgnA:
25.71
3ko0M-1dgnA:
25.71
3ko0N-1dgnA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 GLU A 137
LEU A 136
ASP A 180
ASP A  92
SER A  99
 None
 1.18A 3ko0K-1dysA:
0.0
3ko0L-1dysA:
undetectable
3ko0M-1dysA:
0.0
3ko0N-1dysA:
undetectable		 3ko0K-1dysA:
10.63
3ko0L-1dysA:
10.63
3ko0M-1dysA:
10.63
3ko0N-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 GLU A 343
LEU A 339
SER A 340
PHE A 344
ASP A 252
 None
 1.05A 3ko0K-1ij5A:
7.0
3ko0L-1ij5A:
7.3
3ko0M-1ij5A:
7.1
3ko0N-1ij5A:
7.3		 3ko0K-1ij5A:
17.12
3ko0L-1ij5A:
17.12
3ko0M-1ij5A:
17.12
3ko0N-1ij5A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn1 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Haemophilus
influenzae) 		PF02542
(YgbB) 		5 LEU A  45
LEU A 121
PHE A  82
ILE A  49
ASP A  73
 None
 1.23A 3ko0K-1jn1A:
undetectable
3ko0L-1jn1A:
undetectable
3ko0M-1jn1A:
undetectable
3ko0N-1jn1A:
undetectable		 3ko0K-1jn1A:
20.67
3ko0L-1jn1A:
20.67
3ko0M-1jn1A:
20.67
3ko0N-1jn1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 LEU L 472
LEU L 408
PHE L 502
ILE L 211
PHE L 497
 None
 1.23A 3ko0K-1kfuL:
0.0
3ko0L-1kfuL:
6.6
3ko0M-1kfuL:
0.0
3ko0N-1kfuL:
3.8		 3ko0K-1kfuL:
11.01
3ko0L-1kfuL:
11.01
3ko0M-1kfuL:
11.01
3ko0N-1kfuL:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		5 LEU A 259
ILE A 280
CYH A 263
SER A  16
PHE A  64
 None
 1.17A 3ko0K-1luaA:
0.0
3ko0L-1luaA:
undetectable
3ko0M-1luaA:
0.0
3ko0N-1luaA:
undetectable		 3ko0K-1luaA:
15.25
3ko0L-1luaA:
15.25
3ko0M-1luaA:
15.25
3ko0N-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN

(Schizosaccharomyces
pombe) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 GLU A 150
LEU A 151
ASP A 149
LEU A 110
PHE A 109
 None
 1.16A 3ko0K-1ni3A:
undetectable
3ko0L-1ni3A:
undetectable
3ko0M-1ni3A:
undetectable
3ko0N-1ni3A:
undetectable		 3ko0K-1ni3A:
12.47
3ko0L-1ni3A:
12.47
3ko0M-1ni3A:
12.47
3ko0N-1ni3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 439
LEU A 436
SER A 486
ILE A 423
ASP A 482
 None
 1.11A 3ko0K-1pz3A:
undetectable
3ko0L-1pz3A:
undetectable
3ko0M-1pz3A:
undetectable
3ko0N-1pz3A:
undetectable		 3ko0K-1pz3A:
12.17
3ko0L-1pz3A:
12.17
3ko0M-1pz3A:
12.17
3ko0N-1pz3A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A 325
LEU A 296
SER A 297
PHE A 301
ILE A 304
 None
 1.17A 3ko0K-1pztA:
undetectable
3ko0L-1pztA:
undetectable
3ko0M-1pztA:
undetectable
3ko0N-1pztA:
undetectable		 3ko0K-1pztA:
17.80
3ko0L-1pztA:
17.80
3ko0M-1pztA:
17.80
3ko0N-1pztA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A  64
LEU A  32
PHE A  29
ILE A 108
ASP A  24
 None
 1.22A 3ko0K-1q3bA:
0.3
3ko0L-1q3bA:
undetectable
3ko0M-1q3bA:
0.3
3ko0N-1q3bA:
undetectable		 3ko0K-1q3bA:
17.05
3ko0L-1q3bA:
17.05
3ko0M-1q3bA:
17.05
3ko0N-1q3bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 LEU A 110
ASP A 111
LEU A 243
ASP A 277
SER A 280
 None
 0.99A 3ko0K-1vp4A:
0.0
3ko0L-1vp4A:
undetectable
3ko0M-1vp4A:
0.0
3ko0N-1vp4A:
undetectable		 3ko0K-1vp4A:
13.44
3ko0L-1vp4A:
13.44
3ko0M-1vp4A:
13.44
3ko0N-1vp4A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		5 LEU A  31
ASP A  32
LEU A  68
SER A  69
ILE A  64
 POG  A 201 ( 4.7A)
POG  A 201 ( 4.6A)
None
None
None
 1.16A 3ko0K-1wozA:
0.9
3ko0L-1wozA:
undetectable
3ko0M-1wozA:
0.8
3ko0N-1wozA:
undetectable		 3ko0K-1wozA:
20.57
3ko0L-1wozA:
20.57
3ko0M-1wozA:
20.57
3ko0N-1wozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 303
LEU A 285
SER A 266
ILE A 301
PHE A 224
 None
 1.12A 3ko0K-1x9eA:
0.0
3ko0L-1x9eA:
undetectable
3ko0M-1x9eA:
0.0
3ko0N-1x9eA:
undetectable		 3ko0K-1x9eA:
14.44
3ko0L-1x9eA:
14.44
3ko0M-1x9eA:
14.44
3ko0N-1x9eA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLU A 181
LEU A 177
SER A 178
PHE A 182
ILE A 185
 None
 1.20A 3ko0K-1ykwA:
undetectable
3ko0L-1ykwA:
undetectable
3ko0M-1ykwA:
undetectable
3ko0N-1ykwA:
undetectable		 3ko0K-1ykwA:
12.47
3ko0L-1ykwA:
12.47
3ko0M-1ykwA:
12.47
3ko0N-1ykwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ASP A  13
LEU A  25
SER A  24
ILE A  36
CYH A  10
 None
 1.14A 3ko0K-1zzmA:
0.0
3ko0L-1zzmA:
undetectable
3ko0M-1zzmA:
0.0
3ko0N-1zzmA:
undetectable		 3ko0K-1zzmA:
14.89
3ko0L-1zzmA:
14.89
3ko0M-1zzmA:
14.89
3ko0N-1zzmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLU A 148
LEU A 136
ASP A 162
ILE A 139
SER A 202
 None
 1.25A 3ko0K-2a9fA:
undetectable
3ko0L-2a9fA:
undetectable
3ko0M-2a9fA:
undetectable
3ko0N-2a9fA:
undetectable		 3ko0K-2a9fA:
15.98
3ko0L-2a9fA:
15.98
3ko0M-2a9fA:
15.98
3ko0N-2a9fA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 LEU A 151
SER A 154
PHE A 156
ILE A 331
SER A 186
 None
 1.24A 3ko0K-2c4kA:
undetectable
3ko0L-2c4kA:
undetectable
3ko0M-2c4kA:
undetectable
3ko0N-2c4kA:
undetectable		 3ko0K-2c4kA:
12.83
3ko0L-2c4kA:
12.83
3ko0M-2c4kA:
12.83
3ko0N-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A  59
LEU A 175
ILE A  55
PHE A   7
SER A 168
 None
 1.10A 3ko0K-2e0iA:
undetectable
3ko0L-2e0iA:
undetectable
3ko0M-2e0iA:
undetectable
3ko0N-2e0iA:
undetectable		 3ko0K-2e0iA:
12.59
3ko0L-2e0iA:
12.59
3ko0M-2e0iA:
12.59
3ko0N-2e0iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 5 LEU A  72
LEU A  64
SER A  66
PHE A  65
ILE A  86
 None
 1.21A 3ko0K-2e8mA:
undetectable
3ko0L-2e8mA:
undetectable
3ko0M-2e8mA:
undetectable
3ko0N-2e8mA:
undetectable		 3ko0K-2e8mA:
20.00
3ko0L-2e8mA:
20.00
3ko0M-2e8mA:
20.00
3ko0N-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A 288
LEU A 130
SER A 128
PHE A 129
ILE A 317
 None
 0.92A 3ko0K-2fqxA:
undetectable
3ko0L-2fqxA:
undetectable
3ko0M-2fqxA:
undetectable
3ko0N-2fqxA:
undetectable		 3ko0K-2fqxA:
13.92
3ko0L-2fqxA:
13.92
3ko0M-2fqxA:
13.92
3ko0N-2fqxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 GLU A 160
LEU A 134
LEU A 156
SER A 157
ILE A 164
 None
 1.21A 3ko0K-2ghiA:
undetectable
3ko0L-2ghiA:
undetectable
3ko0M-2ghiA:
undetectable
3ko0N-2ghiA:
undetectable		 3ko0K-2ghiA:
17.14
3ko0L-2ghiA:
17.14
3ko0M-2ghiA:
17.14
3ko0N-2ghiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 845
LEU A 910
PHE A 909
ILE A 888
CYH A 892
 None
 0.97A 3ko0K-2ogvA:
undetectable
3ko0L-2ogvA:
undetectable
3ko0M-2ogvA:
undetectable
3ko0N-2ogvA:
undetectable		 3ko0K-2ogvA:
15.41
3ko0L-2ogvA:
15.41
3ko0M-2ogvA:
15.41
3ko0N-2ogvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 LEU A 117
LEU A  82
SER A  84
PHE A  86
ASP A 257
 None
 1.18A 3ko0K-2q83A:
undetectable
3ko0L-2q83A:
undetectable
3ko0M-2q83A:
undetectable
3ko0N-2q83A:
undetectable		 3ko0K-2q83A:
15.38
3ko0L-2q83A:
15.38
3ko0M-2q83A:
15.38
3ko0N-2q83A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.12A 3ko0K-2v26A:
undetectable
3ko0L-2v26A:
undetectable
3ko0M-2v26A:
undetectable
3ko0N-2v26A:
undetectable		 3ko0K-2v26A:
9.24
3ko0L-2v26A:
9.24
3ko0M-2v26A:
9.24
3ko0N-2v26A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 ASP A 402
LEU A 363
ILE A 398
PHE A 107
ASP A 141
 None
 1.19A 3ko0K-2wn4A:
undetectable
3ko0L-2wn4A:
undetectable
3ko0M-2wn4A:
undetectable
3ko0N-2wn4A:
undetectable		 3ko0K-2wn4A:
13.10
3ko0L-2wn4A:
13.10
3ko0M-2wn4A:
13.10
3ko0N-2wn4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF01590
(GAF) 		5 LEU A 271
LEU A 289
ILE A 372
CYH A 408
PHE A 401
 None
 1.15A 3ko0K-2zmfA:
undetectable
3ko0L-2zmfA:
undetectable
3ko0M-2zmfA:
undetectable
3ko0N-2zmfA:
undetectable		 3ko0K-2zmfA:
17.86
3ko0L-2zmfA:
17.86
3ko0M-2zmfA:
17.86
3ko0N-2zmfA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 LEU A 593
LEU A 604
ILE A 517
SER A 543
PHE A 586
 C  B 935 ( 3.7A)
None
C  B 935 ( 4.2A)
None
None
 1.08A 3ko0K-2zufA:
undetectable
3ko0L-2zufA:
undetectable
3ko0M-2zufA:
undetectable
3ko0N-2zufA:
undetectable		 3ko0K-2zufA:
8.35
3ko0L-2zufA:
8.35
3ko0M-2zufA:
8.35
3ko0N-2zufA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU B 106
LEU B  68
SER B  70
PHE B  71
PHE B  85
 HEM  B 401 ( 4.5A)
None
HEM  B 401 ( 3.8A)
None
None
 1.15A 3ko0K-3a0gB:
undetectable
3ko0L-3a0gB:
undetectable
3ko0M-3a0gB:
undetectable
3ko0N-3a0gB:
undetectable		 3ko0K-3a0gB:
21.92
3ko0L-3a0gB:
21.92
3ko0M-3a0gB:
21.92
3ko0N-3a0gB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 SER X 239
ILE X 278
PHE X 259
ASP X  18
SER X  11
 None
 1.13A 3ko0K-3e13X:
undetectable
3ko0L-3e13X:
undetectable
3ko0M-3e13X:
undetectable
3ko0N-3e13X:
undetectable		 3ko0K-3e13X:
16.67
3ko0L-3e13X:
16.67
3ko0M-3e13X:
16.67
3ko0N-3e13X:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 SER A 171
PHE A 410
ILE A 395
PHE A 298
ASP A 164
 None
 1.20A 3ko0K-3eafA:
undetectable
3ko0L-3eafA:
undetectable
3ko0M-3eafA:
undetectable
3ko0N-3eafA:
undetectable		 3ko0K-3eafA:
12.92
3ko0L-3eafA:
12.92
3ko0M-3eafA:
12.92
3ko0N-3eafA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2

(Homo sapiens) 		PF05527
(DUF758) 		5 LEU A  63
ASP A  62
LEU A  42
SER A  46
SER A  52
 None
 1.21A 3ko0K-3f4mA:
undetectable
3ko0L-3f4mA:
undetectable
3ko0M-3f4mA:
undetectable
3ko0N-3f4mA:
undetectable		 3ko0K-3f4mA:
23.93
3ko0L-3f4mA:
23.93
3ko0M-3f4mA:
23.93
3ko0N-3f4mA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 154
LEU A 146
ILE A 122
CYH A 133
PHE A 132
 None
 1.18A 3ko0K-3fkdA:
undetectable
3ko0L-3fkdA:
undetectable
3ko0M-3fkdA:
undetectable
3ko0N-3fkdA:
undetectable		 3ko0K-3fkdA:
12.82
3ko0L-3fkdA:
12.82
3ko0M-3fkdA:
12.82
3ko0N-3fkdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8w LACTOCOCCAL PROPHAGE
PS3 PROTEIN 05

(Staphylococcus
epidermidis) 		PF13420
(Acetyltransf_4) 		5 LEU A  69
LEU A 115
ILE A 103
CYH A  67
PHE A  87
 None
 1.21A 3ko0K-3g8wA:
undetectable
3ko0L-3g8wA:
undetectable
3ko0M-3g8wA:
undetectable
3ko0N-3g8wA:
undetectable		 3ko0K-3g8wA:
25.00
3ko0L-3g8wA:
25.00
3ko0M-3g8wA:
25.00
3ko0N-3g8wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 312
LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 1.11A 3ko0K-3h11A:
undetectable
3ko0L-3h11A:
undetectable
3ko0M-3h11A:
undetectable
3ko0N-3h11A:
undetectable		 3ko0K-3h11A:
15.79
3ko0L-3h11A:
15.79
3ko0M-3h11A:
15.79
3ko0N-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 LEU A 203
LEU A 161
ILE A 166
CYH A 174
SER A 191
 None
 1.22A 3ko0K-3h7kA:
undetectable
3ko0L-3h7kA:
undetectable
3ko0M-3h7kA:
undetectable
3ko0N-3h7kA:
undetectable		 3ko0K-3h7kA:
14.13
3ko0L-3h7kA:
14.13
3ko0M-3h7kA:
14.13
3ko0N-3h7kA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		5 LEU A 182
ASP A 183
SER A 163
ILE A 169
SER A 289
 None
 1.24A 3ko0K-3hdoA:
undetectable
3ko0L-3hdoA:
undetectable
3ko0M-3hdoA:
undetectable
3ko0N-3hdoA:
undetectable		 3ko0K-3hdoA:
14.61
3ko0L-3hdoA:
14.61
3ko0M-3hdoA:
14.61
3ko0N-3hdoA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 437
ASP A 436
LEU A 416
ILE A 408
PHE A 381
 None
NDG  A4701 ( 3.1A)
None
None
None
 1.20A 3ko0K-3i2tA:
undetectable
3ko0L-3i2tA:
undetectable
3ko0M-3i2tA:
undetectable
3ko0N-3i2tA:
undetectable		 3ko0K-3i2tA:
11.34
3ko0L-3i2tA:
11.34
3ko0M-3i2tA:
11.34
3ko0N-3i2tA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLU A 107
LEU A 106
ASP A 105
SER A 111
ILE A 307
 None
 1.21A 3ko0K-3ip3A:
undetectable
3ko0L-3ip3A:
undetectable
3ko0M-3ip3A:
undetectable
3ko0N-3ip3A:
undetectable		 3ko0K-3ip3A:
16.94
3ko0L-3ip3A:
16.94
3ko0M-3ip3A:
16.94
3ko0N-3ip3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 LEU A 115
LEU A  19
PHE A  48
ASP A 101
SER A  25
 None
 1.17A 3ko0K-3jr3A:
undetectable
3ko0L-3jr3A:
undetectable
3ko0M-3jr3A:
undetectable
3ko0N-3jr3A:
undetectable		 3ko0K-3jr3A:
20.18
3ko0L-3jr3A:
20.18
3ko0M-3jr3A:
20.18
3ko0N-3jr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		5 LEU A  79
ASP A 142
LEU A 170
PHE A 147
ILE A 103
 None
 1.22A 3ko0K-3k4zA:
undetectable
3ko0L-3k4zA:
undetectable
3ko0M-3k4zA:
undetectable
3ko0N-3k4zA:
undetectable		 3ko0K-3k4zA:
16.07
3ko0L-3k4zA:
16.07
3ko0M-3k4zA:
16.07
3ko0N-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 ASP A 229
LEU A 289
SER A 285
PHE A 288
ILE A 251
 FE  A 334 (-3.1A)
None
None
None
None
 1.25A 3ko0K-3ktcA:
undetectable
3ko0L-3ktcA:
undetectable
3ko0M-3ktcA:
undetectable
3ko0N-3ktcA:
undetectable		 3ko0K-3ktcA:
16.22
3ko0L-3ktcA:
16.22
3ko0M-3ktcA:
16.22
3ko0N-3ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 5 LEU A 230
SER A 331
ILE A 254
PHE A 251
SER A 377
 None
 1.14A 3ko0K-3l15A:
undetectable
3ko0L-3l15A:
undetectable
3ko0M-3l15A:
undetectable
3ko0N-3l15A:
undetectable		 3ko0K-3l15A:
20.36
3ko0L-3l15A:
20.36
3ko0M-3l15A:
20.36
3ko0N-3l15A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		5 LEU B  79
ASP B  80
LEU B  37
ILE B  48
PHE B  11
 None
None
None
HEM  B1087 ( 4.4A)
None
 1.15A 3ko0K-3ph2B:
undetectable
3ko0L-3ph2B:
undetectable
3ko0M-3ph2B:
undetectable
3ko0N-3ph2B:
undetectable		 3ko0K-3ph2B:
19.00
3ko0L-3ph2B:
19.00
3ko0M-3ph2B:
19.00
3ko0N-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 107
ASP A 111
SER A 310
PHE A 311
ILE A 276
 None
 1.11A 3ko0K-3r11A:
undetectable
3ko0L-3r11A:
undetectable
3ko0M-3r11A:
undetectable
3ko0N-3r11A:
undetectable		 3ko0K-3r11A:
12.40
3ko0L-3r11A:
12.40
3ko0M-3r11A:
12.40
3ko0N-3r11A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 223
ASP A 222
LEU A 203
ILE A 169
PHE A 253
 None
 1.16A 3ko0K-3skvA:
undetectable
3ko0L-3skvA:
undetectable
3ko0M-3skvA:
undetectable
3ko0N-3skvA:
undetectable		 3ko0K-3skvA:
14.71
3ko0L-3skvA:
14.71
3ko0M-3skvA:
14.71
3ko0N-3skvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj7 GBAA_1210 PROTEIN

(Bacillus
anthracis) 		PF01928
(CYTH) 		5 GLU A  39
LEU A 113
LEU A  45
SER A  43
ILE A 108
 None
 1.21A 3ko0K-3tj7A:
undetectable
3ko0L-3tj7A:
undetectable
3ko0M-3tj7A:
undetectable
3ko0N-3tj7A:
undetectable		 3ko0K-3tj7A:
19.49
3ko0L-3tj7A:
19.49
3ko0M-3tj7A:
19.49
3ko0N-3tj7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 LEU A 334
PHE A 333
ILE A 236
PHE A 264
ASP A 325
 None
 1.10A 3ko0K-3wnpA:
undetectable
3ko0L-3wnpA:
undetectable
3ko0M-3wnpA:
undetectable
3ko0N-3wnpA:
undetectable		 3ko0K-3wnpA:
9.04
3ko0L-3wnpA:
9.04
3ko0M-3wnpA:
9.04
3ko0N-3wnpA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		5 LEU A 336
ASP A 337
LEU A 281
PHE A 284
ILE A 334
 None
 1.22A 3ko0K-3wvsA:
undetectable
3ko0L-3wvsA:
undetectable
3ko0M-3wvsA:
undetectable
3ko0N-3wvsA:
undetectable		 3ko0K-3wvsA:
12.56
3ko0L-3wvsA:
12.56
3ko0M-3wvsA:
12.56
3ko0N-3wvsA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 LEU A  49
ASP A  97
PHE A  18
ASP A 316
PHE A 352
 None
None
None
GOL  A1548 (-3.5A)
None
 1.14A 3ko0K-4aieA:
undetectable
3ko0L-4aieA:
undetectable
3ko0M-4aieA:
undetectable
3ko0N-4aieA:
undetectable		 3ko0K-4aieA:
11.87
3ko0L-4aieA:
11.87
3ko0M-4aieA:
11.87
3ko0N-4aieA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 ASP A 748
LEU A 738
ILE A 769
PHE A 705
PHE A 751
 None
 1.19A 3ko0K-4anjA:
undetectable
3ko0L-4anjA:
undetectable
3ko0M-4anjA:
undetectable
3ko0N-4anjA:
undetectable		 3ko0K-4anjA:
6.93
3ko0L-4anjA:
6.93
3ko0M-4anjA:
6.93
3ko0N-4anjA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4

(Pleurotus
ostreatus) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A 301
LEU A 210
ILE A 310
ASP A 201
SER A 177
 None
None
None
CA  A 402 (-3.0A)
CA  A 402 (-2.4A)
 1.10A 3ko0K-4bm1A:
undetectable
3ko0L-4bm1A:
undetectable
3ko0M-4bm1A:
undetectable
3ko0N-4bm1A:
undetectable		 3ko0K-4bm1A:
16.56
3ko0L-4bm1A:
16.56
3ko0M-4bm1A:
16.56
3ko0N-4bm1A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		5 LEU A 258
LEU A 318
PHE A 316
ILE A 301
ASP A 387
 None
 1.19A 3ko0K-4dj2A:
undetectable
3ko0L-4dj2A:
undetectable
3ko0M-4dj2A:
undetectable
3ko0N-4dj2A:
undetectable		 3ko0K-4dj2A:
15.71
3ko0L-4dj2A:
15.71
3ko0M-4dj2A:
15.71
3ko0N-4dj2A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 LEU A 535
LEU A 561
ILE A 550
ASP A 570
SER A 596
 None
 1.25A 3ko0K-4ecnA:
undetectable
3ko0L-4ecnA:
undetectable
3ko0M-4ecnA:
undetectable
3ko0N-4ecnA:
undetectable		 3ko0K-4ecnA:
9.28
3ko0L-4ecnA:
9.28
3ko0M-4ecnA:
9.28
3ko0N-4ecnA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 GLU A 214
LEU A 228
SER A 231
ILE A 288
PHE A 252
 None
 1.23A 3ko0K-4fidA:
undetectable
3ko0L-4fidA:
undetectable
3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable		 3ko0K-4fidA:
15.16
3ko0L-4fidA:
15.16
3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 GLU A 214
LEU A 228
SER A 231
PHE A 252
PHE A 208
 None
 1.10A 3ko0K-4fidA:
undetectable
3ko0L-4fidA:
undetectable
3ko0M-4fidA:
undetectable
3ko0N-4fidA:
undetectable		 3ko0K-4fidA:
15.16
3ko0L-4fidA:
15.16
3ko0M-4fidA:
15.16
3ko0N-4fidA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  84
LEU A 164
SER A 120
ASP A  70
PHE A 117
 None
 1.20A 3ko0K-4h5iA:
undetectable
3ko0L-4h5iA:
undetectable
3ko0M-4h5iA:
undetectable
3ko0N-4h5iA:
undetectable		 3ko0K-4h5iA:
15.69
3ko0L-4h5iA:
15.69
3ko0M-4h5iA:
15.69
3ko0N-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 5 LEU H  84
LEU H 138
SER H 139
ILE H  88
PHE H 244
 None
 1.09A 3ko0K-4he8H:
1.0
3ko0L-4he8H:
undetectable
3ko0M-4he8H:
0.9
3ko0N-4he8H:
undetectable		 3ko0K-4he8H:
13.81
3ko0L-4he8H:
13.81
3ko0M-4he8H:
13.81
3ko0N-4he8H:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 LEU A 596
ILE A 509
CYH A 512
PHE A 515
ASP A 495
 None
None
None
None
1B2  A 802 (-3.6A)
 1.23A 3ko0K-4hwtA:
0.9
3ko0L-4hwtA:
1.0
3ko0M-4hwtA:
1.1
3ko0N-4hwtA:
1.1		 3ko0K-4hwtA:
14.49
3ko0L-4hwtA:
14.49
3ko0M-4hwtA:
14.49
3ko0N-4hwtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 GLU A 350
LEU A 347
ASP A 346
LEU A 364
ILE A 368
 None
 1.04A 3ko0K-4iggA:
undetectable
3ko0L-4iggA:
undetectable
3ko0M-4iggA:
undetectable
3ko0N-4iggA:
undetectable		 3ko0K-4iggA:
9.16
3ko0L-4iggA:
9.16
3ko0M-4iggA:
9.16
3ko0N-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		5 LEU A 240
ASP A 241
LEU A  45
PHE A  66
ILE A  11
 None
 1.13A 3ko0K-4iwmA:
undetectable
3ko0L-4iwmA:
undetectable
3ko0M-4iwmA:
undetectable
3ko0N-4iwmA:
undetectable		 3ko0K-4iwmA:
17.05
3ko0L-4iwmA:
17.05
3ko0M-4iwmA:
17.05
3ko0N-4iwmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		5 LEU A 108
ASP A 109
LEU A 235
ILE A  98
SER A 353
 None
 0.95A 3ko0K-4j1lA:
undetectable
3ko0L-4j1lA:
undetectable
3ko0M-4j1lA:
undetectable
3ko0N-4j1lA:
undetectable		 3ko0K-4j1lA:
14.29
3ko0L-4j1lA:
14.29
3ko0M-4j1lA:
14.29
3ko0N-4j1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 LEU A 152
SER A 150
PHE A 151
ILE A  30
PHE A  38
 None
 1.16A 3ko0K-4jhiA:
undetectable
3ko0L-4jhiA:
undetectable
3ko0M-4jhiA:
undetectable
3ko0N-4jhiA:
undetectable		 3ko0K-4jhiA:
18.29
3ko0L-4jhiA:
18.29
3ko0M-4jhiA:
18.29
3ko0N-4jhiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 LEU A1480
ASP A1476
LEU A1524
SER A1523
ILE A1481
 None
 1.20A 3ko0K-4lnzA:
1.7
3ko0L-4lnzA:
1.7
3ko0M-4lnzA:
1.7
3ko0N-4lnzA:
1.6		 3ko0K-4lnzA:
14.90
3ko0L-4lnzA:
14.90
3ko0M-4lnzA:
14.90
3ko0N-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 298
ASP A 322
LEU A 311
ILE A 285
PHE A 352
 None
 1.25A 3ko0K-4m7eA:
undetectable
3ko0L-4m7eA:
undetectable
3ko0M-4m7eA:
undetectable
3ko0N-4m7eA:
undetectable		 3ko0K-4m7eA:
8.34
3ko0L-4m7eA:
8.34
3ko0M-4m7eA:
8.34
3ko0N-4m7eA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p53 CYCLASE

(Streptomyces
hygroscopicus) 		PF01761
(DHQ_synthase) 		5 LEU A 129
LEU A  85
PHE A  92
ILE A  67
PHE A 119
 None
 1.20A 3ko0K-4p53A:
undetectable
3ko0L-4p53A:
undetectable
3ko0M-4p53A:
undetectable
3ko0N-4p53A:
undetectable		 3ko0K-4p53A:
12.62
3ko0L-4p53A:
12.62
3ko0M-4p53A:
12.62
3ko0N-4p53A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 GLU A 132
LEU A  70
SER A  67
ILE A 292
PHE A  65
 UNX  A 420 ( 3.3A)
None
UNX  A 420 ( 3.0A)
None
UNX  A 408 ( 4.8A)
 1.19A 3ko0K-4pwyA:
undetectable
3ko0L-4pwyA:
undetectable
3ko0M-4pwyA:
undetectable
3ko0N-4pwyA:
undetectable		 3ko0K-4pwyA:
18.85
3ko0L-4pwyA:
18.85
3ko0M-4pwyA:
18.85
3ko0N-4pwyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 LEU A  74
LEU A  51
SER A  54
ILE A  78
PHE A1722
 None
 1.22A 3ko0K-4r04A:
undetectable
3ko0L-4r04A:
undetectable
3ko0M-4r04A:
undetectable
3ko0N-4r04A:
undetectable		 3ko0K-4r04A:
4.44
3ko0L-4r04A:
4.44
3ko0M-4r04A:
4.44
3ko0N-4r04A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 LEU A 279
ASP A 277
LEU A 298
SER A 285
ASP A 269
 None
 1.26A 3ko0K-4r1zA:
undetectable
3ko0L-4r1zA:
undetectable
3ko0M-4r1zA:
undetectable
3ko0N-4r1zA:
undetectable		 3ko0K-4r1zA:
14.25
3ko0L-4r1zA:
14.25
3ko0M-4r1zA:
14.25
3ko0N-4r1zA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 377
ASP A 405
LEU A 390
ILE A 382
CYH A 409
 None
 0.98A 3ko0K-4r5dA:
undetectable
3ko0L-4r5dA:
undetectable
3ko0M-4r5dA:
undetectable
3ko0N-4r5dA:
undetectable		 3ko0K-4r5dA:
10.93
3ko0L-4r5dA:
10.93
3ko0M-4r5dA:
10.93
3ko0N-4r5dA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 LEU A 114
ASP A 113
LEU A  95
ILE A 120
PHE A 162
 None
 1.08A 3ko0K-4s1aA:
undetectable
3ko0L-4s1aA:
undetectable
3ko0M-4s1aA:
undetectable
3ko0N-4s1aA:
undetectable		 3ko0K-4s1aA:
18.98
3ko0L-4s1aA:
18.98
3ko0M-4s1aA:
18.98
3ko0N-4s1aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 SER A 368
ILE A 413
ASP A 346
SER A 363
PHE A 420
 None
 1.19A 3ko0K-4u3tA:
undetectable
3ko0L-4u3tA:
undetectable
3ko0M-4u3tA:
undetectable
3ko0N-4u3tA:
undetectable		 3ko0K-4u3tA:
15.76
3ko0L-4u3tA:
15.76
3ko0M-4u3tA:
15.76
3ko0N-4u3tA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL

(Plasmodium
berghei) 		no annotation 5 LEU A  57
ASP A  60
PHE A 115
ILE A 138
CYH A 142
 None
 1.24A 3ko0K-4u5aA:
undetectable
3ko0L-4u5aA:
1.8
3ko0M-4u5aA:
1.9
3ko0N-4u5aA:
1.9		 3ko0K-4u5aA:
20.30
3ko0L-4u5aA:
20.30
3ko0M-4u5aA:
20.30
3ko0N-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8t ZYRO0G01672P

(Zygosaccharomyces
rouxii) 		PF04146
(YTH) 		5 LEU A 188
CYH A 236
PHE A 235
ASP A 297
SER A 202
 None
None
None
C  O   1 ( 4.8A)
None
 1.22A 3ko0K-4u8tA:
undetectable
3ko0L-4u8tA:
undetectable
3ko0M-4u8tA:
undetectable
3ko0N-4u8tA:
undetectable		 3ko0K-4u8tA:
19.21
3ko0L-4u8tA:
19.21
3ko0M-4u8tA:
19.21
3ko0N-4u8tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 400
ASP A 401
LEU A 409
PHE A 408
ILE A 396
 None
 1.09A 3ko0K-4up7A:
undetectable
3ko0L-4up7A:
undetectable
3ko0M-4up7A:
undetectable
3ko0N-4up7A:
undetectable		 3ko0K-4up7A:
9.51
3ko0L-4up7A:
9.51
3ko0M-4up7A:
9.51
3ko0N-4up7A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pyrococcus
horikoshii) 		PF01867
(Cas_Cas1) 		5 LEU A   6
ASP A  39
LEU A  14
ILE A   8
PHE A  65
 None
 1.09A 3ko0K-4wj0A:
undetectable
3ko0L-4wj0A:
undetectable
3ko0M-4wj0A:
undetectable
3ko0N-4wj0A:
undetectable		 3ko0K-4wj0A:
16.94
3ko0L-4wj0A:
16.94
3ko0M-4wj0A:
16.94
3ko0N-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 GLU C 592
LEU C 593
LEU C 359
ILE C 590
CYH C 396
 None
 1.21A 3ko0K-4xgcC:
2.6
3ko0L-4xgcC:
2.6
3ko0M-4xgcC:
2.7
3ko0N-4xgcC:
2.6		 3ko0K-4xgcC:
8.97
3ko0L-4xgcC:
8.97
3ko0M-4xgcC:
8.97
3ko0N-4xgcC:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2830
ASP A2854
LEU A2842
SER A2844
PHE A2845
 None
 1.22A 3ko0K-4z37A:
undetectable
3ko0L-4z37A:
undetectable
3ko0M-4z37A:
undetectable
3ko0N-4z37A:
undetectable		 3ko0K-4z37A:
9.61
3ko0L-4z37A:
9.61
3ko0M-4z37A:
9.61
3ko0N-4z37A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 588
ASP A 587
LEU A 577
ILE A 573
PHE A 627
 None
 1.07A 3ko0K-4z61A:
undetectable
3ko0L-4z61A:
undetectable
3ko0M-4z61A:
undetectable
3ko0N-4z61A:
undetectable		 3ko0K-4z61A:
10.84
3ko0L-4z61A:
10.84
3ko0M-4z61A:
10.84
3ko0N-4z61A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 578
ASP A 577
LEU A 567
ILE A 563
PHE A 617
 None
 1.10A 3ko0K-4z64A:
undetectable
3ko0L-4z64A:
undetectable
3ko0M-4z64A:
undetectable
3ko0N-4z64A:
undetectable		 3ko0K-4z64A:
11.79
3ko0L-4z64A:
11.79
3ko0M-4z64A:
11.79
3ko0N-4z64A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 LEU A  56
ASP A  57
LEU A 126
PHE A 122
SER A  40
 None
None
None
None
DMS  A1314 ( 3.7A)
 1.22A 3ko0K-5advA:
undetectable
3ko0L-5advA:
undetectable
3ko0M-5advA:
undetectable
3ko0N-5advA:
undetectable		 3ko0K-5advA:
15.55
3ko0L-5advA:
15.55
3ko0M-5advA:
15.55
3ko0N-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 GLU A 724
LEU A 735
ILE A  21
PHE A 115
ASP A 593
 None
 1.25A 3ko0K-5ah5A:
undetectable
3ko0L-5ah5A:
undetectable
3ko0M-5ah5A:
undetectable
3ko0N-5ah5A:
undetectable		 3ko0K-5ah5A:
7.86
3ko0L-5ah5A:
7.86
3ko0M-5ah5A:
7.86
3ko0N-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 GLU A 106
LEU A 109
LEU A  50
SER A  51
ILE A  46
 None
 1.06A 3ko0K-5azdA:
1.7
3ko0L-5azdA:
1.5
3ko0M-5azdA:
1.7
3ko0N-5azdA:
1.7		 3ko0K-5azdA:
15.53
3ko0L-5azdA:
15.53
3ko0M-5azdA:
15.53
3ko0N-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU A 387
LEU B 168
SER B  83
PHE B  82
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.17A 3ko0K-5b8iA:
undetectable
3ko0L-5b8iA:
undetectable
3ko0M-5b8iA:
undetectable
3ko0N-5b8iA:
undetectable		 3ko0K-5b8iA:
13.49
3ko0L-5b8iA:
13.49
3ko0M-5b8iA:
13.49
3ko0N-5b8iA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 GLU A  23
LEU A  26
ILE A  61
ASP A 417
SER A 403
 None
 1.20A 3ko0K-5cykA:
undetectable
3ko0L-5cykA:
undetectable
3ko0M-5cykA:
undetectable
3ko0N-5cykA:
undetectable		 3ko0K-5cykA:
10.91
3ko0L-5cykA:
10.91
3ko0M-5cykA:
10.91
3ko0N-5cykA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		5 GLU A 265
LEU A 261
ASP A 263
LEU A  24
ILE A 277
 None
 1.16A 3ko0K-5d86A:
undetectable
3ko0L-5d86A:
undetectable
3ko0M-5d86A:
undetectable
3ko0N-5d86A:
undetectable		 3ko0K-5d86A:
16.92
3ko0L-5d86A:
16.92
3ko0M-5d86A:
16.92
3ko0N-5d86A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.23A 3ko0K-5dwzC:
undetectable
3ko0L-5dwzC:
undetectable
3ko0M-5dwzC:
undetectable
3ko0N-5dwzC:
undetectable		 3ko0K-5dwzC:
14.11
3ko0L-5dwzC:
14.11
3ko0M-5dwzC:
14.11
3ko0N-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 LEU E 209
LEU E 285
PHE E 246
ILE E 213
ASP E 237
 None
 1.20A 3ko0K-5esvE:
undetectable
3ko0L-5esvE:
undetectable
3ko0M-5esvE:
undetectable
3ko0N-5esvE:
undetectable		 3ko0K-5esvE:
20.39
3ko0L-5esvE:
20.39
3ko0M-5esvE:
20.39
3ko0N-5esvE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 LEU D 382
LEU D 394
ILE D 401
CYH D 405
ASP D 358
 None
 1.19A 3ko0K-5exrD:
undetectable
3ko0L-5exrD:
undetectable
3ko0M-5exrD:
undetectable
3ko0N-5exrD:
undetectable		 3ko0K-5exrD:
13.78
3ko0L-5exrD:
13.78
3ko0M-5exrD:
13.78
3ko0N-5exrD:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		5 LEU A 271
LEU A 230
ILE A 105
ASP A 240
SER A  51
 None
None
None
SR  A 401 ( 4.7A)
SR  A 401 ( 4.2A)
 1.12A 3ko0K-5hxsA:
undetectable
3ko0L-5hxsA:
undetectable
3ko0M-5hxsA:
undetectable
3ko0N-5hxsA:
undetectable		 3ko0K-5hxsA:
12.62
3ko0L-5hxsA:
12.62
3ko0M-5hxsA:
12.62
3ko0N-5hxsA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 LEU A  94
SER A  95
PHE A  69
ILE A  74
SER A 164
 None
 1.15A 3ko0K-5hyhA:
undetectable
3ko0L-5hyhA:
undetectable
3ko0M-5hyhA:
undetectable
3ko0N-5hyhA:
undetectable		 3ko0K-5hyhA:
14.19
3ko0L-5hyhA:
14.19
3ko0M-5hyhA:
14.19
3ko0N-5hyhA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 164
LEU B 143
SER B 134
ILE B 183
ASP B 138
 None
 1.12A 3ko0K-5k1cB:
undetectable
3ko0L-5k1cB:
undetectable
3ko0M-5k1cB:
undetectable
3ko0N-5k1cB:
undetectable		 3ko0K-5k1cB:
9.96
3ko0L-5k1cB:
9.96
3ko0M-5k1cB:
9.96
3ko0N-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 368
ILE A 413
ASP A 346
SER A 363
PHE A 420
 None
 1.21A 3ko0K-5kshA:
undetectable
3ko0L-5kshA:
undetectable
3ko0M-5kshA:
undetectable
3ko0N-5kshA:
undetectable		 3ko0K-5kshA:
10.70
3ko0L-5kshA:
10.70
3ko0M-5kshA:
10.70
3ko0N-5kshA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 5 LEU A 320
ASP A 319
LEU A 428
PHE A 427
SER A 290
 None
 1.16A 3ko0K-5m3xA:
undetectable
3ko0L-5m3xA:
undetectable
3ko0M-5m3xA:
undetectable
3ko0N-5m3xA:
undetectable		 3ko0K-5m3xA:
21.74
3ko0L-5m3xA:
21.74
3ko0M-5m3xA:
21.74
3ko0N-5m3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 5 LEU A 107
ASP A 108
LEU A 129
ILE A 104
PHE A  75
 None
 1.17A 3ko0K-5ubvA:
undetectable
3ko0L-5ubvA:
undetectable
3ko0M-5ubvA:
undetectable
3ko0N-5ubvA:
undetectable		 3ko0K-5ubvA:
21.05
3ko0L-5ubvA:
21.05
3ko0M-5ubvA:
21.05
3ko0N-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 ASP A1440
LEU A1448
SER A1446
ILE A1877
PHE A1360
 None
 1.21A 3ko0K-5v6tA:
1.0
3ko0L-5v6tA:
1.0
3ko0M-5v6tA:
undetectable
3ko0N-5v6tA:
1.0		 3ko0K-5v6tA:
11.44
3ko0L-5v6tA:
11.44
3ko0M-5v6tA:
11.44
3ko0N-5v6tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmb DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 316
PHE A 315
ILE A 627
ASP A 640
PHE A 633
 None
EDO  A 815 ( 4.8A)
None
None
None
 1.19A 3ko0K-5wmbA:
undetectable
3ko0L-5wmbA:
undetectable
3ko0M-5wmbA:
undetectable
3ko0N-5wmbA:
undetectable		 3ko0K-5wmbA:
13.36
3ko0L-5wmbA:
13.36
3ko0M-5wmbA:
13.36
3ko0N-5wmbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 LEU B 111
ASP B 109
SER B 145
ILE B 150
ASP B  72
 None
 1.13A 3ko0K-5y3rB:
undetectable
3ko0L-5y3rB:
undetectable
3ko0M-5y3rB:
undetectable
3ko0N-5y3rB:
undetectable		 3ko0K-5y3rB:
11.39
3ko0L-5y3rB:
11.39
3ko0M-5y3rB:
11.39
3ko0N-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens) 		no annotation 5 LEU E 167
PHE E 113
ILE E 147
ASP A  48
SER A  46
 None
 1.22A 3ko0K-6d6uE:
undetectable
3ko0L-6d6uE:
undetectable
3ko0M-6d6uE:
undetectable
3ko0N-6d6uE:
undetectable		 3ko0K-6d6uE:
21.15
3ko0L-6d6uE:
21.15
3ko0M-6d6uE:
21.15
3ko0N-6d6uE:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
 None
 1.09A 3ko0K-6evjB:
undetectable
3ko0L-6evjB:
undetectable
3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable		 3ko0K-6evjB:
17.92
3ko0L-6evjB:
17.92
3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		no annotation 5 LEU A 148
ASP A 171
LEU A 137
ILE A 133
PHE A 187
 None
 1.18A 3ko0K-6fg8A:
undetectable
3ko0L-6fg8A:
undetectable
3ko0M-6fg8A:
undetectable
3ko0N-6fg8A:
undetectable		 3ko0K-6fg8A:
18.00
3ko0L-6fg8A:
18.00
3ko0M-6fg8A:
18.00
3ko0N-6fg8A:
18.00